locus-tag	class	description
K3X22_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X22_00035	COG0300	oxidoreductase activity
K3X22_00065	COG1802	Transcriptional regulator
K3X22_00075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X22_00085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X22_00090	COG1082	Xylose isomerase domain protein TIM barrel
K3X22_00090	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K3X22_00095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X22_00100	COG0372	Belongs to the citrate synthase family
K3X22_00105	COG0673	inositol 2-dehydrogenase activity
K3X22_00115	COG0673	inositol 2-dehydrogenase activity
K3X22_00125	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_00130	COG0028	Belongs to the TPP enzyme family
K3X22_00165	COG3909	cytochrome
K3X22_00170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X22_00170	COG2010	Cytochrome c
K3X22_00175	COG2132	Multicopper oxidase
K3X22_00200	COG0010	Belongs to the arginase family
K3X22_00205	COG1166	arginine decarboxylase activity
K3X22_00220	COG0010	Belongs to the arginase family
K3X22_00225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3X22_00250	COG0351	phosphomethylpyrimidine kinase
K3X22_00260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X22_00275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X22_00280	COG3938	Belongs to the proline racemase family
K3X22_00285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_00290	COG3938	Belongs to the proline racemase family
K3X22_00295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X22_00300	COG1802	Transcriptional regulator
K3X22_00310	COG0028	Belongs to the TPP enzyme family
K3X22_00315	COG1349	DNA-binding transcription factor activity
K3X22_00330	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X22_00335	COG3842	ATPase activity
K3X22_00350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3X22_00360	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_00375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X22_00390	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3X22_00400	COG0583	DNA-binding transcription factor activity
K3X22_00410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X22_00410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X22_00415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X22_00435	COG0251	oxidation-reduction process
K3X22_00450	COG0745	RESPONSE REGULATOR receiver
K3X22_00455	COG2205	protein histidine kinase activity
K3X22_00475	COG1132	(ABC) transporter
K3X22_00480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X22_00485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X22_00490	COG1960	acyl-CoA dehydrogenase activity
K3X22_00495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X22_00515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3X22_00520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3X22_00525	COG1335	isochorismatase
K3X22_00545	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3X22_00555	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3X22_00575	COG0514	ATP-dependent DNA helicase (RecQ)
K3X22_00580	COG3022	response to hydroperoxide
K3X22_00585	COG3437	response regulator, receiver
K3X22_00585	COG4999	Histidine kinase
K3X22_00585	COG2205	protein histidine kinase activity
K3X22_00585	COG3850	Histidine kinase
K3X22_00605	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_00605	COG3321	synthase
K3X22_00605	COG0604	alcohol dehydrogenase
K3X22_00615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3X22_00620	COG2814	Major facilitator Superfamily
K3X22_00630	COG2267	carboxylic ester hydrolase activity
K3X22_00640	COG2423	ornithine cyclodeaminase activity
K3X22_00665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3X22_00745	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3X22_00755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_00755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X22_00760	COG0697	spore germination
K3X22_00765	COG0741	lytic transglycosylase activity
K3X22_00770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X22_00775	COG1720	tRNA m6t6A37 methyltransferase activity
K3X22_00780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3X22_00785	COG0303	'Molybdopterin
K3X22_00790	COG0746	molybdenum cofactor guanylyltransferase activity
K3X22_00795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3X22_00810	COG0583	DNA-binding transcription factor activity
K3X22_00850	COG1960	acyl-CoA dehydrogenase activity
K3X22_00855	COG0009	L-threonylcarbamoyladenylate synthase
K3X22_00860	COG1678	Uncharacterized ACR, COG1678
K3X22_00895	COG3119	arylsulfatase activity
K3X22_00945	COG0494	nUDIX hydrolase
K3X22_00950	COG3034	peptidoglycan biosynthetic process
K3X22_00955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3X22_00965	COG0242	peptide deformylase activity
K3X22_00970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3X22_00975	COG2261	transglycosylase associated protein
K3X22_00985	COG0328	RNA-DNA hybrid ribonuclease activity
K3X22_00995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3X22_01005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3X22_01010	COG1758	RNA polymerase activity
K3X22_01015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3X22_01025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3X22_01030	COG1280	lysine exporter protein (LysE YggA)
K3X22_01035	COG0736	holo-[acyl-carrier-protein] synthase activity
K3X22_01040	COG0681	Belongs to the peptidase S26 family
K3X22_01045	COG0571	ribonuclease III activity
K3X22_01050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3X22_01060	COG1381	Involved in DNA repair and RecF pathway recombination
K3X22_01100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3X22_01105	COG0745	RESPONSE REGULATOR receiver
K3X22_01110	COG2205	protein histidine kinase activity
K3X22_01120	COG1660	Displays ATPase and GTPase activities
K3X22_01130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X22_01140	COG0840	transmembrane signaling receptor activity
K3X22_01175	COG0300	oxidoreductase activity
K3X22_01185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X22_01195	COG0501	Belongs to the peptidase M48B family
K3X22_01200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X22_01215	COG0250	Participates in transcription elongation, termination and antitermination
K3X22_01220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3X22_01225	COG0081	regulation of translation
K3X22_01230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3X22_01235	COG0222	ribosome binding
K3X22_01240	COG0085	RNA polymerase activity
K3X22_01245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3X22_01255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3X22_01260	COG0049	tRNA binding
K3X22_01265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3X22_01270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X22_01285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3X22_01290	COG0088	Forms part of the polypeptide exit tunnel
K3X22_01295	COG0089	rRNA binding
K3X22_01310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3X22_01315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3X22_01320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3X22_01325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3X22_01330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3X22_01365	COG0255	Belongs to the universal ribosomal protein uL29 family
K3X22_01370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3X22_01375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3X22_01380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3X22_01385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3X22_01390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3X22_01395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3X22_01400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3X22_01405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3X22_01410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3X22_01415	COG1841	ribosomal large subunit assembly
K3X22_01430	COG0200	Binds to the 23S rRNA
K3X22_01435	COG0201	protein transport
K3X22_01440	COG0563	adenylate kinase activity
K3X22_01445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3X22_01450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3X22_01455	COG0202	RNA polymerase activity
K3X22_01460	COG0203	ribosomal protein L17
K3X22_01470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3X22_01485	COG0564	pseudouridine synthase activity
K3X22_01490	COG0546	phosphoglycolate phosphatase activity
K3X22_01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X22_01505	COG4597	amino acid ABC transporter
K3X22_01510	COG0765	amino acid transport
K3X22_01515	COG1126	abc transporter atp-binding protein
K3X22_01540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3X22_01545	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_01550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3X22_01560	COG0706	membrane insertase activity
K3X22_01565	COG5001	Diguanylate cyclase
K3X22_01570	COG0037	tRNA processing
K3X22_01585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3X22_01590	COG0594	ribonuclease P activity
K3X22_01595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3X22_01625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3X22_01630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3X22_01635	COG3047	cAMP biosynthetic process
K3X22_01635	COG2885	chlorophyll binding
K3X22_01655	COG1739	Uncharacterized protein family UPF0029
K3X22_01670	COG1435	thymidine kinase activity
K3X22_01675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X22_01680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X22_01700	COG1136	(ABC) transporter
K3X22_01705	COG0438	transferase activity, transferring glycosyl groups
K3X22_01720	COG0187	DNA topoisomerase II activity
K3X22_01725	COG4335	DNA alkylation repair
K3X22_01730	COG0101	tRNA pseudouridine synthase activity
K3X22_01735	COG3106	COG3106 Predicted ATPase
K3X22_01745	COG3768	UPF0283 membrane protein
K3X22_01770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3X22_01780	COG1131	(ABC) transporter
K3X22_01785	COG0842	Transport permease protein
K3X22_01790	COG0616	signal peptide processing
K3X22_01790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X22_01810	COG0322	excinuclease ABC activity
K3X22_01815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X22_01825	COG0314	molybdopterin synthase activity
K3X22_01835	COG1183	phosphatidylcholine synthase activity
K3X22_01850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X22_01860	COG2391	methyltransferase activity
K3X22_01870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X22_01875	COG2264	protein methyltransferase activity
K3X22_01900	COG2814	Major facilitator Superfamily
K3X22_01910	COG1045	serine acetyltransferase
K3X22_01915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X22_01925	COG1570	exodeoxyribonuclease VII activity
K3X22_01935	COG0590	tRNA wobble adenosine to inosine editing
K3X22_01955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X22_01960	COG0154	amidase activity
K3X22_01970	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3X22_01980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3X22_01995	COG0670	Belongs to the BI1 family
K3X22_02005	COG0583	DNA-binding transcription factor activity
K3X22_02010	COG0604	alcohol dehydrogenase
K3X22_02010	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_02010	COG3321	synthase
K3X22_02020	COG0483	inositol monophosphate 1-phosphatase activity
K3X22_02030	COG0402	S-adenosylhomocysteine deaminase activity
K3X22_02035	COG2239	Acts as a magnesium transporter
K3X22_02040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3X22_02045	COG1692	metallophosphoesterase
K3X22_02055	COG3273	potassium ion transport
K3X22_02055	COG0471	metal ion transport
K3X22_02090	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X22_02135	COG0601	transmembrane transport
K3X22_02140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X22_02145	COG0444	Belongs to the ABC transporter superfamily
K3X22_02150	COG1124	(ABC) transporter
K3X22_02160	COG2197	response regulator
K3X22_02190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3X22_02210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3X22_02220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X22_02225	COG0287	Prephenate dehydrogenase
K3X22_02235	COG1490	D-aminoacyl-tRNA deacylase activity
K3X22_02260	COG3853	Toxic anion resistance protein (TelA)
K3X22_02290	COG0552	protein localization to endoplasmic reticulum
K3X22_02300	COG2917	probably involved in intracellular septation
K3X22_02310	COG1469	GTP cyclohydrolase I activity
K3X22_02320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X22_02330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X22_02335	COG0752	glycyl-tRNA synthetase alpha subunit
K3X22_02345	COG0751	glycine-tRNA ligase activity
K3X22_02350	COG0574	Belongs to the PEP-utilizing enzyme family
K3X22_02350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X22_02370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3X22_02375	COG0697	spore germination
K3X22_02380	COG1160	GTP binding
K3X22_02385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3X22_02420	COG1802	Transcriptional regulator
K3X22_02430	COG0505	Belongs to the CarA family
K3X22_02450	COG3474	cytochrome
K3X22_02455	COG0321	lipoyl(octanoyl) transferase activity
K3X22_02480	COG1477	protein flavinylation
K3X22_02485	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X22_02490	COG1805	sodium ion transport
K3X22_02500	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X22_02540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3X22_02550	COG0826	peptidase U32
K3X22_02570	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_02575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3X22_02585	COG2267	carboxylic ester hydrolase activity
K3X22_02595	COG2188	Transcriptional regulator
K3X22_02605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X22_02605	COG0116	Belongs to the methyltransferase superfamily
K3X22_02610	COG1132	(ABC) transporter
K3X22_02615	COG0318	PFAM AMP-dependent synthetase and ligase
K3X22_02625	COG3916	Acyl-homoserine-lactone synthase
K3X22_02645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3X22_02655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3X22_02660	COG5328	Belongs to the UPF0262 family
K3X22_02685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3X22_02695	COG1530	ribonuclease E activity
K3X22_02700	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3X22_02735	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3X22_02735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3X22_02745	COG0243	molybdopterin cofactor binding
K3X22_02750	COG0437	4 iron, 4 sulfur cluster binding
K3X22_02755	COG0348	domain, Protein
K3X22_02765	COG3005	denitrification pathway
K3X22_02770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X22_02770	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X22_02780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3X22_02795	COG0140	phosphoribosyl-ATP diphosphatase activity
K3X22_02800	COG0107	imidazoleglycerol-phosphate synthase activity
K3X22_02810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X22_02820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3X22_02830	COG0131	Imidazoleglycerol-phosphate dehydratase
K3X22_02860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3X22_02865	COG0758	DNA mediated transformation
K3X22_02880	COG0312	modulator of DNA gyrase
K3X22_02890	COG0109	protoheme IX farnesyltransferase activity
K3X22_02900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3X22_02925	COG0612	Peptidase, M16
K3X22_02940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3X22_02945	COG2311	Membrane
K3X22_02950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3X22_02955	COG0659	secondary active sulfate transmembrane transporter activity
K3X22_02970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X22_02990	COG1802	Transcriptional regulator
K3X22_03000	COG0006	proline dipeptidase activity
K3X22_03005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X22_03010	COG2423	ornithine cyclodeaminase activity
K3X22_03015	COG1522	sequence-specific DNA binding
K3X22_03020	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_03025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X22_03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X22_03040	COG0601	transmembrane transport
K3X22_03045	COG4166	transmembrane transport
K3X22_03050	COG0583	DNA-binding transcription factor activity
K3X22_03055	COG0006	proline dipeptidase activity
K3X22_03065	COG0527	aspartate kinase activity
K3X22_03070	COG1917	Cupin 2, conserved barrel domain protein
K3X22_03075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X22_03090	COG0527	aspartate kinase activity
K3X22_03095	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_03120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X22_03125	COG0443	Heat shock 70 kDa protein
K3X22_03135	COG3842	ATPase activity
K3X22_03145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3X22_03155	COG0805	protein transport
K3X22_03165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3X22_03180	COG1862	Preprotein translocase
K3X22_03185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3X22_03195	COG3737	Protein of unknown function (DUF498/DUF598)
K3X22_03200	COG4133	protoheme IX ABC transporter activity
K3X22_03205	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X22_03210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X22_03220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X22_03225	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_03240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X22_03250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3X22_03270	COG0305	Participates in initiation and elongation during chromosome replication
K3X22_03275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X22_03280	COG0418	dihydroorotase activity
K3X22_03300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X22_03330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3X22_03330	COG3608	succinylglutamate desuccinylase aspartoacylase
K3X22_03345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3X22_03360	COG0175	sulfate reduction
K3X22_03365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3X22_03375	COG1522	sequence-specific DNA binding
K3X22_03385	COG4191	Histidine kinase
K3X22_03400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X22_03405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X22_03410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X22_03430	COG1024	Enoyl-CoA hydratase
K3X22_03435	COG1960	acyl-CoA dehydrogenase activity
K3X22_03440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3X22_03470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3X22_03490	COG2354	Protein conserved in bacteria
K3X22_03495	COG0697	spore germination
K3X22_03500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3X22_03515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3X22_03525	COG1357	PFAM Pentapeptide repeats (8 copies)
K3X22_03530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X22_03545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K3X22_03550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3X22_03555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3X22_03580	COG1138	Cytochrome C-type biogenesis protein
K3X22_03585	COG3088	subunit of a heme lyase
K3X22_03590	COG1024	Enoyl-CoA hydratase
K3X22_03600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X22_03605	COG2333	competence protein COMEC
K3X22_03605	COG0658	competence protein
K3X22_03610	COG0583	DNA-binding transcription factor activity
K3X22_03615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X22_03620	COG0174	glutamine synthetase
K3X22_03625	COG0519	Catalyzes the synthesis of GMP from XMP
K3X22_03635	COG4215	(ABC) transporter
K3X22_03665	COG0504	CTP synthase activity
K3X22_03675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3X22_03700	COG1760	l-serine dehydratase
K3X22_03705	COG2832	Protein of unknown function (DUF454)
K3X22_03710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3X22_03720	COG0330	HflC and HflK could
K3X22_03725	COG0330	HflC and HflK could
K3X22_03740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X22_03755	COG1053	succinate dehydrogenase
K3X22_03760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K3X22_03765	COG0632	four-way junction helicase activity
K3X22_03770	COG2255	four-way junction helicase activity
K3X22_03785	COG0824	Thioesterase
K3X22_03810	COG2885	chlorophyll binding
K3X22_03820	COG0037	tRNA processing
K3X22_03825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3X22_03835	COG3239	Fatty acid desaturase
K3X22_03840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3X22_03845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X22_03850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X22_03860	COG1024	Enoyl-CoA hydratase
K3X22_03920	COG4964	Belongs to the GSP D family
K3X22_03955	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_03960	COG0277	FAD linked oxidase domain protein
K3X22_03970	COG2133	pyrroloquinoline quinone binding
K3X22_03995	COG0471	metal ion transport
K3X22_03995	COG3273	potassium ion transport
K3X22_04000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X22_04000	COG1754	DNA topoisomerase type I activity
K3X22_04000	COG1754	DNA topoisomerase type I activity
K3X22_04000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X22_04005	COG0210	DNA helicase
K3X22_04015	COG0489	protein tyrosine kinase activity
K3X22_04020	COG2001	Belongs to the MraZ family
K3X22_04025	COG0275	rRNA processing
K3X22_04040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3X22_04045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3X22_04050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3X22_04070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_04075	COG1473	amidohydrolase
K3X22_04080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3X22_04090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X22_04110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3X22_04115	COG0546	phosphoglycolate phosphatase activity
K3X22_04125	COG1960	acyl-CoA dehydrogenase activity
K3X22_04135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X22_04140	COG4770	biotin carboxylase activity
K3X22_04155	COG1024	Enoyl-CoA hydratase
K3X22_04165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X22_04170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X22_04180	COG0649	NAD binding
K3X22_04215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3X22_04220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X22_04235	COG0713	ATP synthesis coupled electron transport
K3X22_04250	COG1007	ATP synthesis coupled electron transport
K3X22_04260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3X22_04270	COG0513	Belongs to the DEAD box helicase family
K3X22_04300	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_04305	COG0667	Aldo Keto reductase
K3X22_04315	COG3246	L-lysine catabolic process to acetate
K3X22_04325	COG0824	Thioesterase
K3X22_04325	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X22_04395	COG1984	allophanate hydrolase subunit 2
K3X22_04405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3X22_04415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3X22_04420	COG1335	isochorismatase
K3X22_04440	COG1309	transcriptional regulator
K3X22_04445	COG0358	DNA primase activity
K3X22_04450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3X22_04470	COG0432	Pfam Uncharacterised protein family UPF0047
K3X22_04480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X22_04480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X22_04520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3X22_04525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X22_04560	COG0564	pseudouridine synthase activity
K3X22_04590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X22_04610	COG1164	Oligoendopeptidase f
K3X22_04615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3X22_04620	COG1530	ribonuclease E activity
K3X22_04625	COG0425	Belongs to the sulfur carrier protein TusA family
K3X22_04630	COG0785	Cytochrome C biogenesis protein
K3X22_04660	COG0114	fumarate hydratase activity
K3X22_04700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X22_04705	COG0604	alcohol dehydrogenase
K3X22_04720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X22_04725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X22_04730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3X22_04740	COG0494	nUDIX hydrolase
K3X22_04750	COG3264	Mechanosensitive ion channel
K3X22_04750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X22_04755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X22_04815	COG4964	Belongs to the GSP D family
K3X22_04885	COG0784	Response regulator, receiver
K3X22_04885	COG2205	protein histidine kinase activity
K3X22_04885	COG5002	protein histidine kinase activity
K3X22_04895	COG0840	transmembrane signaling receptor activity
K3X22_04900	COG2201	protein-glutamate methylesterase activity
K3X22_04905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3X22_04920	COG2801	Transposase and inactivated derivatives
K3X22_04930	COG0745	RESPONSE REGULATOR receiver
K3X22_04935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3X22_04940	COG0835	chemotaxis
K3X22_04950	COG0745	RESPONSE REGULATOR receiver
K3X22_04960	COG1653	transport
K3X22_04965	COG1175	transmembrane transport
K3X22_04970	COG0395	ABC-type sugar transport system, permease component
K3X22_04975	COG3842	ATPase activity
K3X22_04980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3X22_04995	COG0739	heme binding
K3X22_05000	COG2833	Protein of unknown function (DUF455)
K3X22_05005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3X22_05015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3X22_05030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3X22_05040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3X22_05045	COG0494	nUDIX hydrolase
K3X22_05050	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X22_05055	COG3956	TIGRFAM MazG family protein
K3X22_05060	COG1473	amidohydrolase
K3X22_05065	COG0010	Belongs to the arginase family
K3X22_05075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3X22_05080	COG2890	protein-(glutamine-N5) methyltransferase activity
K3X22_05090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3X22_05095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X22_05100	COG0259	pyridoxamine-phosphate oxidase activity
K3X22_05125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3X22_05135	COG0440	acetolactate synthase activity
K3X22_05140	COG0028	Belongs to the TPP enzyme family
K3X22_05145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3X22_05165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3X22_05175	COG2814	Major facilitator Superfamily
K3X22_05180	COG1797	cobyrinic acid a,c-diamide synthase activity
K3X22_05190	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3X22_05220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3X22_05230	COG0166	Belongs to the GPI family
K3X22_05255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3X22_05260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3X22_05265	COG1329	Transcriptional regulator
K3X22_05270	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3X22_05275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3X22_05280	COG0840	transmembrane signaling receptor activity
K3X22_05285	COG1522	sequence-specific DNA binding
K3X22_05295	COG2968	Membrane
K3X22_05300	COG2873	o-acetylhomoserine
K3X22_05325	COG2391	methyltransferase activity
K3X22_05340	COG0785	Cytochrome C biogenesis protein
K3X22_05360	COG3258	Cytochrome c
K3X22_05365	COG0737	Belongs to the 5'-nucleotidase family
K3X22_05370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X22_05455	COG0215	cysteine-tRNA ligase activity
K3X22_05460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X22_05470	COG0800	Aldolase
K3X22_05475	COG0129	dihydroxy-acid dehydratase activity
K3X22_05485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X22_05510	COG2814	Major facilitator Superfamily
K3X22_05530	COG0542	response to heat
K3X22_05555	COG0516	GMP reductase activity
K3X22_05555	COG0517	IMP dehydrogenase activity
K3X22_05560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3X22_05560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3X22_05570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3X22_05575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X22_05585	COG1217	gtp-binding protein TYPA
K3X22_05595	COG0121	glutamine amidotransferase
K3X22_05600	COG1024	Enoyl-CoA hydratase
K3X22_05615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3X22_05640	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_05640	COG2030	dehydratase
K3X22_05650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3X22_05655	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X22_05660	COG3396	Phenylacetate-CoA oxygenase
K3X22_05665	COG3460	Phenylacetate-CoA oxygenase
K3X22_05670	COG3396	Phenylacetate-CoA oxygenase
K3X22_05695	COG0084	hydrolase, TatD family'
K3X22_05705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3X22_05710	COG1686	Belongs to the peptidase S11 family
K3X22_05815	COG0629	single-stranded DNA binding
K3X22_05820	COG0741	lytic transglycosylase activity
K3X22_05825	COG2207	Transcriptional regulator
K3X22_05835	COG0528	UMP kinase activity
K3X22_05840	COG0233	cytoplasmic translational termination
K3X22_05845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3X22_05855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3X22_05860	COG0750	zinc metalloprotease
K3X22_05870	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X22_05880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X22_05885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X22_05895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X22_05905	COG0482	sulfurtransferase activity
K3X22_05915	COG0745	RESPONSE REGULATOR receiver
K3X22_05920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3X22_05925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3X22_05940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3X22_05945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X22_05950	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3X22_05960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X22_05965	COG1612	heme a metabolic process
K3X22_05970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3X22_05990	COG2945	thiolester hydrolase activity
K3X22_05995	COG1959	2 iron, 2 sulfur cluster binding
K3X22_06005	COG1104	cysteine desulfurase activity
K3X22_06010	COG0719	Fe-S assembly protein
K3X22_06030	COG0396	ATPase activity
K3X22_06035	COG0719	Fe-S assembly protein
K3X22_06050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X22_06055	COG1309	transcriptional regulator
K3X22_06060	COG2326	polyphosphate kinase activity
K3X22_06065	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3X22_06090	COG0519	Catalyzes the synthesis of GMP from XMP
K3X22_06090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X22_06095	COG5598	trimethylamine methyltransferase
K3X22_06115	COG5002	protein histidine kinase activity
K3X22_06130	COG0573	inorganic phosphate transmembrane transporter activity
K3X22_06140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3X22_06150	COG0745	RESPONSE REGULATOR receiver
K3X22_06160	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K3X22_06170	COG0714	Associated with various cellular activities
K3X22_06175	COG3831	ATPase activity
K3X22_06185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3X22_06195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3X22_06200	COG0052	Belongs to the universal ribosomal protein uS2 family
K3X22_06205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3X22_06205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3X22_06210	COG2313	pseudouridylate synthase activity
K3X22_06225	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_06250	COG2814	Major facilitator Superfamily
K3X22_06255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3X22_06275	COG2084	Dehydrogenase
K3X22_06285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3X22_06295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X22_06300	COG0569	domain protein
K3X22_06305	COG2204	response regulator
K3X22_06310	COG5000	phosphorelay sensor kinase activity
K3X22_06315	COG2204	response regulator
K3X22_06320	COG3852	Histidine kinase
K3X22_06325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3X22_06330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X22_06335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X22_06335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3X22_06345	COG1058	Belongs to the CinA family
K3X22_06345	COG1546	Belongs to the CinA family
K3X22_06350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3X22_06355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3X22_06370	COG4974	Belongs to the 'phage' integrase family
K3X22_06380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3X22_06390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3X22_06410	COG0194	GDP metabolic process
K3X22_06415	COG1561	YicC-like family, N-terminal region
K3X22_06425	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3X22_06485	COG0626	cystathionine gamma-synthase activity
K3X22_06510	COG2321	neutral zinc metallopeptidase
K3X22_06520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3X22_06560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3X22_06565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3X22_06570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3X22_06590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3X22_06595	COG3743	rRNA binding
K3X22_06595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3X22_06600	COG0457	Tetratricopeptide repeat
K3X22_06605	COG2204	response regulator
K3X22_06615	COG0047	phosphoribosylformylglycinamidine synthase activity
K3X22_06620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X22_06625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3X22_06640	COG0646	methionine synthase
K3X22_06640	COG1410	methionine synthase
K3X22_06650	COG5012	cobalamin binding
K3X22_06665	COG2166	iron-sulfur cluster assembly
K3X22_06675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3X22_06680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3X22_06685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3X22_06695	COG0456	acetyltransferase
K3X22_06740	COG0004	ammonium transporteR
K3X22_06750	COG4536	flavin adenine dinucleotide binding
K3X22_06755	COG0433	COG0433 Predicted ATPase
K3X22_06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X22_06775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X22_06805	COG1522	sequence-specific DNA binding
K3X22_06815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3X22_06830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3X22_06835	COG1410	methionine synthase
K3X22_06835	COG0646	methionine synthase
K3X22_06880	COG0730	response to heat
K3X22_06900	COG2205	protein histidine kinase activity
K3X22_06900	COG2198	Histidine kinase
K3X22_06900	COG0784	Response regulator, receiver
K3X22_06930	COG0105	UTP biosynthetic process
K3X22_06935	COG0488	(ABC) transporter
K3X22_06940	COG2095	MarC family integral membrane protein
K3X22_06955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X22_06970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3X22_06980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3X22_06985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X22_06990	COG0038	chloride channel
K3X22_06995	COG0277	FAD linked oxidase domain protein
K3X22_07005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X22_07010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3X22_07015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3X22_07020	COG0849	cell division
K3X22_07025	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3X22_07030	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3X22_07035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3X22_07050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3X22_07055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3X22_07070	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3X22_07085	COG1741	Belongs to the pirin family
K3X22_07105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3X22_07120	COG0436	Aminotransferase
K3X22_07135	COG2010	Cytochrome c
K3X22_07135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X22_07160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3X22_07165	COG2155	Conserved Protein
K3X22_07175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K3X22_07180	COG0308	aminopeptidase N
K3X22_07185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X22_07190	COG0826	peptidase U32
K3X22_07225	COG1473	amidohydrolase
K3X22_07230	COG0006	proline dipeptidase activity
K3X22_07240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3X22_07245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3X22_07250	COG0436	Aminotransferase
K3X22_07260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X22_07290	COG3588	fructose-bisphosphate aldolase
K3X22_07300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3X22_07305	COG0022	dehydrogenase e1 component
K3X22_07305	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X22_07310	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X22_07400	COG4695	Portal protein
K3X22_07415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3X22_07420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X22_07425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X22_07435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3X22_07445	COG0360	Binds together with S18 to 16S ribosomal RNA
K3X22_07450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3X22_07455	COG0359	binds to the 23S rRNA
K3X22_07465	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3X22_07485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3X22_07515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3X22_07520	COG1127	ABC transporter
K3X22_07545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3X22_07555	COG4221	oxidoreductase activity
K3X22_07575	COG1160	GTP binding
K3X22_07595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X22_07600	COG5265	(ABC) transporter
K3X22_07615	COG2962	Rard protein
K3X22_07660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X22_07660	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X22_07675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_07685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3X22_07695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3X22_07705	COG0156	8-amino-7-oxononanoate synthase activity
K3X22_07730	COG0406	alpha-ribazole phosphatase activity
K3X22_07755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3X22_07765	COG0343	queuine tRNA-ribosyltransferase activity
K3X22_07770	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X22_07785	COG0316	Belongs to the HesB IscA family
K3X22_07790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X22_07795	COG0149	triose-phosphate isomerase activity
K3X22_07800	COG0076	glutamate decarboxylase activity
K3X22_07805	COG1272	protein, Hemolysin III
K3X22_07815	COG0488	(ABC) transporter
K3X22_07825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X22_07840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3X22_07845	COG0416	fatty acid biosynthetic process
K3X22_07850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3X22_07855	COG0776	regulation of translation
K3X22_07870	COG0717	Belongs to the dCTP deaminase family
K3X22_07880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3X22_07885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3X22_07890	COG1472	Belongs to the glycosyl hydrolase 3 family
K3X22_07900	COG0018	arginyl-trna synthetase
K3X22_07905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X22_07910	COG0316	Belongs to the HesB IscA family
K3X22_07915	COG2081	HI0933 family
K3X22_07925	COG1957	nucleoside hydrolase
K3X22_07930	COG0456	acetyltransferase
K3X22_07935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3X22_07950	COG0384	phenazine biosynthesis protein PhzF
K3X22_07965	COG0148	phosphopyruvate hydratase activity
K3X22_07990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X22_07995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3X22_08005	COG0315	cyclic pyranopterin monophosphate synthase activity
K3X22_08010	COG0303	'Molybdopterin
K3X22_08015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3X22_08040	COG2267	carboxylic ester hydrolase activity
K3X22_08055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3X22_08065	COG3220	belongs to the UPF0276 family
K3X22_08085	COG1393	Belongs to the ArsC family
K3X22_08090	COG1278	Cold shock
K3X22_08100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3X22_08150	COG0534	Mate efflux family protein
K3X22_08155	COG2951	lytic endotransglycosylase activity
K3X22_08160	COG2326	polyphosphate kinase activity
K3X22_08170	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3X22_08180	COG0625	glutathione transferase activity
K3X22_08190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3X22_08200	COG0488	(ABC) transporter
K3X22_08230	COG0519	Catalyzes the synthesis of GMP from XMP
K3X22_08230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X22_08235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X22_08245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X22_08250	COG0028	Belongs to the TPP enzyme family
K3X22_08270	COG0840	transmembrane signaling receptor activity
K3X22_08320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3X22_08345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3X22_08350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3X22_08355	COG3750	Belongs to the UPF0335 family
K3X22_08370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X22_08380	COG2205	protein histidine kinase activity
K3X22_08390	COG0745	RESPONSE REGULATOR receiver
K3X22_08395	COG3800	Transcriptional regulator
K3X22_08395	COG1396	sequence-specific DNA binding
K3X22_08420	COG0410	ABC transporter
K3X22_08425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X22_08435	COG0318	PFAM AMP-dependent synthetase and ligase
K3X22_08450	COG1309	transcriptional regulator
K3X22_08465	COG0439	Biotin carboxylase
K3X22_08470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3X22_08490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3X22_08495	COG0740	serine-type endopeptidase activity
K3X22_08500	COG1177	transmembrane transport
K3X22_08505	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X22_08515	COG3842	ATPase activity
K3X22_08535	COG1136	(ABC) transporter
K3X22_08560	COG0483	inositol monophosphate 1-phosphatase activity
K3X22_08565	COG0583	DNA-binding transcription factor activity
K3X22_08580	COG0019	diaminopimelate decarboxylase activity
K3X22_08590	COG0033	Phosphoglucomutase
K3X22_08595	COG0525	valine-tRNA ligase activity
K3X22_08610	COG1132	(ABC) transporter
K3X22_08615	COG0354	folic acid binding
K3X22_08625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3X22_08635	COG1492	cobalamin metabolic process
K3X22_08650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3X22_08660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X22_08665	COG0720	synthase
K3X22_08670	COG0602	queuosine metabolic process
K3X22_08675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3X22_08700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K3X22_08705	COG3842	ATPase activity
K3X22_08710	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X22_08715	COG1177	transmembrane transport
K3X22_08720	COG0174	glutamine synthetase
K3X22_08725	COG0318	PFAM AMP-dependent synthetase and ligase
K3X22_08730	COG0154	amidase activity
K3X22_08735	COG2135	peptidase activity
K3X22_08745	COG0737	Belongs to the 5'-nucleotidase family
K3X22_08755	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3X22_08765	COG3257	ureidoglycine aminohydrolase activity
K3X22_08780	COG1393	Belongs to the ArsC family
K3X22_08785	COG0534	Mate efflux family protein
K3X22_08820	COG1960	acyl-CoA dehydrogenase activity
K3X22_08830	COG0625	glutathione transferase activity
K3X22_08835	COG0183	Belongs to the thiolase family
K3X22_08845	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X22_08845	COG1024	Enoyl-CoA hydratase
K3X22_08860	COG0318	PFAM AMP-dependent synthetase and ligase
K3X22_08875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3X22_08880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3X22_08885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3X22_08895	COG0280	phosphate acetyltransferase
K3X22_08895	COG0281	malic enzyme
K3X22_08905	COG2204	response regulator
K3X22_08920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3X22_08930	COG3739	integral membrane protein
K3X22_08940	COG2267	carboxylic ester hydrolase activity
K3X22_08950	COG0556	nucleotide-excision repair
K3X22_08960	COG0583	DNA-binding transcription factor activity
K3X22_08965	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_08970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_08980	COG0583	DNA-binding transcription factor activity
K3X22_08985	COG0022	dehydrogenase e1 component
K3X22_09010	COG0174	glutamine synthetase
K3X22_09055	COG0463	Glycosyl transferase, family 2
K3X22_09065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3X22_09080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X22_09095	COG1573	uracil-dna glycosylase
K3X22_09110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X22_09120	COG1496	oxidoreductase activity
K3X22_09130	COG1522	sequence-specific DNA binding
K3X22_09135	COG0492	ferredoxin-NADP+ reductase activity
K3X22_09145	COG2046	Belongs to the sulfate adenylyltransferase family
K3X22_09145	COG0529	Catalyzes the synthesis of activated sulfate
K3X22_09165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3X22_09170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3X22_09180	COG0442	prolyl-tRNA aminoacylation
K3X22_09195	COG0628	permease
K3X22_09205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3X22_09210	COG0248	Ppx GppA phosphatase
K3X22_09230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3X22_09235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X22_09245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X22_09245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X22_09260	COG4770	biotin carboxylase activity
K3X22_09285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X22_09290	COG2814	Major facilitator Superfamily
K3X22_09295	COG1396	sequence-specific DNA binding
K3X22_09295	COG3800	Transcriptional regulator
K3X22_09310	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_09315	COG3119	arylsulfatase activity
K3X22_09320	COG1309	transcriptional regulator
K3X22_09330	COG1280	lysine exporter protein (LysE YggA)
K3X22_09335	COG4176	ABC-type proline glycine betaine transport system permease component
K3X22_09340	COG4175	Glycine betaine
K3X22_09350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K3X22_09360	COG1054	Belongs to the UPF0176 family
K3X22_09380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3X22_09400	COG0228	four-way junction DNA binding
K3X22_09405	COG0778	Nitroreductase
K3X22_09410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3X22_09420	COG0336	Belongs to the RNA methyltransferase TrmD family
K3X22_09425	COG0335	large ribosomal subunit rRNA binding
K3X22_09430	COG0254	rRNA binding
K3X22_09435	COG0189	ligase activity
K3X22_09435	COG4067	protein conserved in archaea
K3X22_09440	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X22_09440	COG0489	protein tyrosine kinase activity
K3X22_09450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X22_09480	COG3191	aminopeptidase activity
K3X22_09490	COG0071	Belongs to the small heat shock protein (HSP20) family
K3X22_09500	COG0247	lactate metabolic process
K3X22_09505	COG0277	FAD linked oxidase domain protein
K3X22_09510	COG0277	FAD linked oxidase domain protein
K3X22_09530	COG0714	Associated with various cellular activities
K3X22_09540	COG3622	Belongs to the hyi family
K3X22_09560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X22_09560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X22_09585	COG1765	OsmC-like protein
K3X22_09590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X22_09595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3X22_09605	COG2885	chlorophyll binding
K3X22_09610	COG2186	Transcriptional regulator
K3X22_09620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X22_09625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X22_09630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X22_09635	COG0356	it plays a direct role in the translocation of protons across the membrane
K3X22_09655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3X22_09685	COG0642	Histidine kinase
K3X22_09710	COG0328	RNA-DNA hybrid ribonuclease activity
K3X22_09720	COG3617	BRO family, N-terminal domain
K3X22_09765	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X22_09770	COG0567	Dehydrogenase, E1 component
K3X22_09785	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X22_09795	COG0039	L-malate dehydrogenase activity
K3X22_09810	COG2301	Belongs to the HpcH HpaI aldolase family
K3X22_09820	COG2030	dehydratase
K3X22_09855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3X22_09860	COG4181	ATPase activity
K3X22_09870	COG2197	response regulator
K3X22_09890	COG0348	domain, Protein
K3X22_09895	COG2010	Cytochrome c
K3X22_09920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X22_09925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X22_09940	COG0459	protein refolding
K3X22_09950	COG1858	cytochrome C peroxidase
K3X22_09960	COG1227	inorganic diphosphatase activity
K3X22_09975	COG2030	dehydratase
K3X22_09980	COG0196	riboflavin kinase activity
K3X22_09990	COG2983	Belongs to the UPF0260 family
K3X22_10000	COG0596	Alpha beta hydrolase
K3X22_10000	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X22_10030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3X22_10035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3X22_10040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3X22_10045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3X22_10050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X22_10065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3X22_10105	COG0772	Belongs to the SEDS family
K3X22_10110	COG0768	penicillin binding
K3X22_10130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X22_10160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X22_10170	COG0534	Mate efflux family protein
K3X22_10180	COG0509	glycine decarboxylation via glycine cleavage system
K3X22_10185	COG3118	belongs to the thioredoxin family
K3X22_10250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3X22_10255	COG0339	signal peptide processing
K3X22_10260	COG0765	amino acid transport
K3X22_10275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3X22_10280	COG0756	dUTP diphosphatase activity
K3X22_10285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3X22_10310	COG0606	chelatase, subunit chli
K3X22_10320	COG0189	ligase activity
K3X22_10325	COG0792	nuclease activity
K3X22_10330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3X22_10340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3X22_10355	COG0180	Tryptophanyl-tRNA synthetase
K3X22_10360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3X22_10365	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3X22_10370	COG0124	histidyl-tRNA synthetase
K3X22_10375	COG2900	Belongs to the SlyX family
K3X22_10395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X22_10405	COG3845	ABC transporter
K3X22_10410	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X22_10415	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X22_10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X22_10430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X22_10440	COG0667	Aldo Keto reductase
K3X22_10455	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X22_10460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3X22_10460	COG1042	CoA-binding domain protein
K3X22_10460	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X22_10470	COG4608	Belongs to the ABC transporter superfamily
K3X22_10480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X22_10485	COG0601	transmembrane transport
K3X22_10500	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_10540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X22_10545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3X22_10550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3X22_10555	COG0747	negative chemotaxis
K3X22_10570	COG0778	Nitroreductase
K3X22_10580	COG0217	transcriptional regulatory protein
K3X22_10590	COG1846	Transcriptional regulator
K3X22_10605	COG0471	metal ion transport
K3X22_10605	COG3273	potassium ion transport
K3X22_10610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3X22_10615	COG1214	PFAM Peptidase M22, glycoprotease
K3X22_10625	COG1744	ABC transporter substrate-binding protein PnrA-like
K3X22_10630	COG3845	ABC transporter
K3X22_10635	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X22_10640	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X22_10660	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_10675	COG2197	response regulator
K3X22_10685	COG0604	alcohol dehydrogenase
K3X22_10690	COG2937	Belongs to the GPAT DAPAT family
K3X22_10695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X22_10695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X22_10710	COG0813	purine-nucleoside phosphorylase activity
K3X22_10720	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X22_10720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X22_10735	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X22_10740	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_10745	COG1960	acyl-CoA dehydrogenase activity
K3X22_10750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X22_10755	COG3800	Transcriptional regulator
K3X22_10755	COG1396	sequence-specific DNA binding
K3X22_10760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X22_10780	COG0625	glutathione transferase activity
K3X22_10800	COG1401	restriction endodeoxyribonuclease activity
K3X22_10835	COG0515	serine threonine protein kinase
K3X22_10835	COG2815	serine threonine protein kinase
K3X22_10840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K3X22_10860	COG2353	YceI-like domain
K3X22_10870	COG0012	GTP binding
K3X22_10875	COG0159	tryptophan synthase activity
K3X22_10890	COG0513	Belongs to the DEAD box helicase family
K3X22_10910	COG0193	aminoacyl-tRNA hydrolase activity
K3X22_10925	COG0133	tryptophan synthase activity
K3X22_10930	COG0135	phosphoribosylanthranilate isomerase activity
K3X22_10940	COG0776	regulation of translation
K3X22_10945	COG0539	negative regulation of cytoplasmic translation
K3X22_10955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3X22_10980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3X22_10985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3X22_10990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3X22_10995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3X22_11000	COG1253	flavin adenine dinucleotide binding
K3X22_11005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3X22_11010	COG1702	phosphate starvation-inducible protein PhoH
K3X22_11025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X22_11035	COG1047	Peptidyl-prolyl cis-trans
K3X22_11045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X22_11050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X22_11055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X22_11060	COG2267	carboxylic ester hydrolase activity
K3X22_11075	COG2267	carboxylic ester hydrolase activity
K3X22_11085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X22_11095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X22_11120	COG2824	Alkylphosphonate utilization operon protein PhnA
K3X22_11135	COG0481	GTPase activity
K3X22_11155	COG1105	Belongs to the carbohydrate kinase PfkB family
K3X22_11165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3X22_11175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3X22_11190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3X22_11200	COG1132	(ABC) transporter
K3X22_11205	COG1703	isobutyryl-CoA mutase activity
K3X22_11210	COG1643	Atp-dependent helicase
K3X22_11220	COG0306	phosphate transporter
K3X22_11230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3X22_11235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3X22_11255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X22_11270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K3X22_11285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3X22_11300	COG0346	lactoylglutathione lyase activity
K3X22_11320	COG0778	Nitroreductase
K3X22_11330	COG1872	DUF167
K3X22_11335	COG3152	Membrane
K3X22_11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3X22_11370	COG0540	Belongs to the ATCase OTCase family
K3X22_11380	COG1573	uracil-dna glycosylase
K3X22_11385	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3X22_11395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X22_11405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3X22_11425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3X22_11430	COG0142	geranyltranstransferase activity
K3X22_11455	COG0583	DNA-binding transcription factor activity
K3X22_11465	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_11480	COG2818	Glycosylase
K3X22_11485	COG2951	lytic endotransglycosylase activity
K3X22_11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X22_11505	COG0165	Argininosuccinate lyase
K3X22_11510	COG0019	diaminopimelate decarboxylase activity
K3X22_11520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3X22_11545	COG1162	GTPase activity
K3X22_11555	COG0737	Belongs to the 5'-nucleotidase family
K3X22_11560	COG2816	NAD+ diphosphatase activity
K3X22_11575	COG3474	cytochrome
K3X22_11580	COG4166	transmembrane transport
K3X22_11585	COG4174	ABC transporter (Permease)
K3X22_11590	COG4239	(ABC) transporter, permease
K3X22_11595	COG4172	Belongs to the ABC transporter superfamily
K3X22_11600	COG1686	Belongs to the peptidase S11 family
K3X22_11605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3X22_11610	COG2813	Specifically methylates the guanine in position
K3X22_11620	COG0408	coproporphyrinogen oxidase activity
K3X22_11630	COG1846	Transcriptional regulator
K3X22_11635	COG0183	Belongs to the thiolase family
K3X22_11640	COG0181	hydroxymethylbilane synthase activity
K3X22_11645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3X22_11655	COG0513	Belongs to the DEAD box helicase family
K3X22_11660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3X22_11675	COG0288	reversible hydration of carbon dioxide
K3X22_11685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X22_11690	COG0791	NLP P60 protein
K3X22_11700	COG2050	protein possibly involved in aromatic compounds catabolism
K3X22_11725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3X22_11740	COG0679	Auxin Efflux Carrier
K3X22_11750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3X22_11755	COG1671	Belongs to the UPF0178 family
K3X22_11765	COG1280	lysine exporter protein (LysE YggA)
K3X22_11770	COG2897	thiosulfate sulfurtransferase activity
K3X22_11780	COG0004	ammonium transporteR
K3X22_11785	COG0347	Belongs to the P(II) protein family
K3X22_11815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X22_11825	COG0584	glycerophosphoryl diester phosphodiesterase
K3X22_11835	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3X22_11845	COG0742	ribosomal rna small subunit methyltransferase
K3X22_11850	COG0024	Methionine aminopeptidase
K3X22_11855	COG1489	DNA binding
K3X22_11860	COG1058	Belongs to the CinA family
K3X22_11860	COG1546	Belongs to the CinA family
K3X22_11880	COG0583	DNA-binding transcription factor activity
K3X22_11890	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X22_11890	COG1902	pentaerythritol trinitrate reductase activity
K3X22_11915	COG1266	CAAX protease self-immunity
K3X22_11920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3X22_11925	COG0285	dihydrofolate synthase activity
K3X22_11940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3X22_11955	COG0686	Belongs to the AlaDH PNT family
K3X22_11965	COG0668	transmembrane transport
K3X22_11970	COG1970	mechanosensitive ion channel activity
K3X22_11980	COG0072	phenylalanine-tRNA ligase activity
K3X22_11980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X22_12000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3X22_12005	COG1595	DNA-templated transcription, initiation
K3X22_12010	COG3795	YCII-related domain
K3X22_12020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3X22_12025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3X22_12035	COG0469	pyruvate kinase activity
K3X22_12060	COG3384	dioxygenase
K3X22_12075	COG4948	Mandelate Racemase Muconate Lactonizing
K3X22_12110	COG0825	malonyl-CoA metabolic process
K3X22_12130	COG2884	Cell division ATP-binding protein ftsE
K3X22_12165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3X22_12170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X22_12180	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X22_12195	COG0284	orotidine-5'-phosphate decarboxylase activity
K3X22_12215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3X22_12230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3X22_12245	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3X22_12265	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X22_12295	COG3383	formate dehydrogenase (NAD+) activity
K3X22_12310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X22_12335	COG0612	Peptidase, M16
K3X22_12340	COG0612	Peptidase, M16
K3X22_12350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3X22_12355	COG0138	bifunctional purine biosynthesis protein purh
K3X22_12375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3X22_12380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3X22_12385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3X22_12390	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3X22_12410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3X22_12425	COG1185	polyribonucleotide nucleotidyltransferase activity
K3X22_12440	COG1733	regulation of RNA biosynthetic process
K3X22_12450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3X22_12455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3X22_12465	COG0560	Phosphoserine phosphatase
K3X22_12490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3X22_12510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X22_12515	COG2171	N-acyltransferase activity
K3X22_12555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X22_12565	COG0557	exoribonuclease II activity
K3X22_12570	COG2951	lytic endotransglycosylase activity
K3X22_12590	COG1051	belongs to the nudix hydrolase family
K3X22_12595	COG0793	Belongs to the peptidase S41A family
K3X22_12605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X22_12615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3X22_12620	COG0799	negative regulation of ribosome biogenesis
K3X22_12630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X22_12630	COG3264	Mechanosensitive ion channel
K3X22_12635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3X22_12640	COG0066	3-isopropylmalate dehydratase activity
K3X22_12655	COG0473	3-isopropylmalate dehydrogenase activity
K3X22_12670	COG1960	acyl-CoA dehydrogenase activity
K3X22_12675	COG2329	Antibiotic biosynthesis monooxygenase
K3X22_12685	COG2233	PERMEase
K3X22_12690	COG0277	FAD linked oxidase domain protein
K3X22_12700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X22_12705	COG2186	Transcriptional regulator
K3X22_12710	COG0560	Phosphoserine phosphatase
K3X22_12720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3X22_12725	COG0765	amino acid transport
K3X22_12730	COG1126	abc transporter atp-binding protein
K3X22_12735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X22_12745	COG4608	Belongs to the ABC transporter superfamily
K3X22_12750	COG0444	Belongs to the ABC transporter superfamily
K3X22_12755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X22_12760	COG0601	transmembrane transport
K3X22_12765	COG0747	negative chemotaxis
K3X22_12770	COG1802	Transcriptional regulator
K3X22_12800	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X22_12805	COG4172	Belongs to the ABC transporter superfamily
K3X22_12815	COG0601	transmembrane transport
K3X22_12825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X22_12835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X22_12855	COG0798	PFAM Bile acid sodium symporter
K3X22_12860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3X22_12895	COG2010	Cytochrome c
K3X22_12910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3X22_12915	COG2010	Cytochrome c
K3X22_12920	COG3391	amine dehydrogenase activity
K3X22_12925	COG1522	sequence-specific DNA binding
K3X22_12940	COG0535	radical SAM domain protein
K3X22_12955	COG2197	response regulator
K3X22_12965	COG1024	Enoyl-CoA hydratase
K3X22_12995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3X22_13010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3X22_13030	COG1766	The M ring may be actively involved in energy transduction
K3X22_13040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X22_13045	COG1338	Plays a role in the flagellum-specific transport system
K3X22_13050	COG4948	Mandelate Racemase Muconate Lactonizing
K3X22_13060	COG0583	DNA-binding transcription factor activity
K3X22_13065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X22_13070	COG0563	adenylate kinase activity
K3X22_13080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3X22_13085	COG0517	IMP dehydrogenase activity
K3X22_13085	COG0617	tRNA 3'-terminal CCA addition
K3X22_13085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3X22_13095	COG5002	protein histidine kinase activity
K3X22_13095	COG2176	DNA-directed DNA polymerase activity
K3X22_13100	COG0243	molybdopterin cofactor binding
K3X22_13190	COG0183	Belongs to the thiolase family
K3X22_13230	COG1674	ftsk spoiiie
K3X22_13245	COG0154	amidase activity
K3X22_13250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3X22_13275	COG2835	tetraacyldisaccharide 4'-kinase activity
K3X22_13290	COG0708	Exodeoxyribonuclease III
K3X22_13300	COG0789	Transcriptional regulator
K3X22_13310	COG0456	acetyltransferase
K3X22_13315	COG0745	RESPONSE REGULATOR receiver
K3X22_13350	COG0495	leucyl-tRNA aminoacylation
K3X22_13365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_13365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X22_13370	COG3264	Mechanosensitive ion channel
K3X22_13370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X22_13375	COG1024	Enoyl-CoA hydratase
K3X22_13380	COG4221	oxidoreductase activity
K3X22_13385	COG0312	modulator of DNA gyrase
K3X22_13390	COG0483	inositol monophosphate 1-phosphatase activity
K3X22_13395	COG1609	Transcriptional regulator
K3X22_13405	COG0489	protein tyrosine kinase activity
K3X22_13405	COG3206	protein involved in exopolysaccharide biosynthesis
K3X22_13425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3X22_13430	COG0297	glycogen (starch) synthase activity
K3X22_13440	COG0438	transferase activity, transferring glycosyl groups
K3X22_13465	COG0438	transferase activity, transferring glycosyl groups
K3X22_13495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X22_13515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3X22_13515	COG0662	Cupin 2, conserved barrel domain protein
K3X22_13535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3X22_13555	COG1194	a g-specific adenine glycosylase
K3X22_13565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X22_13570	COG3034	peptidoglycan biosynthetic process
K3X22_13575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3X22_13580	COG0617	tRNA 3'-terminal CCA addition
K3X22_13585	COG0494	nUDIX hydrolase
K3X22_13595	COG0745	RESPONSE REGULATOR receiver
K3X22_13605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X22_13615	COG0137	argininosuccinate synthase activity
K3X22_13630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X22_13635	COG0473	3-isopropylmalate dehydrogenase activity
K3X22_13650	COG0435	Glutathione S-transferase
K3X22_13655	COG0281	malic enzyme
K3X22_13655	COG0280	phosphate acetyltransferase
K3X22_13660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3X22_13665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3X22_13670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K3X22_13675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3X22_13680	COG1420	regulation of RNA biosynthetic process
K3X22_13685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3X22_13690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3X22_13695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X22_13710	COG0357	Ribosomal RNA small subunit methyltransferase G
K3X22_13715	COG0445	tRNA wobble uridine modification
K3X22_13720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3X22_13725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3X22_13730	COG1981	membrane
K3X22_13735	COG0424	maF-like protein
K3X22_13740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X22_13745	COG0237	dephospho-CoA kinase activity
K3X22_13750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3X22_13760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3X22_13765	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3X22_13790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3X22_13795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3X22_13810	COG1040	competence protein
K3X22_13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3X22_13835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3X22_13855	COG0779	Required for maturation of 30S ribosomal subunits
K3X22_13870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3X22_13880	COG0494	nUDIX hydrolase
K3X22_13885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3X22_13890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3X22_13895	COG0653	protein targeting
K3X22_13905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K3X22_13910	COG2003	Belongs to the UPF0758 family
K3X22_13915	COG0484	heat shock protein binding
K3X22_13920	COG0443	Heat shock 70 kDa protein
K3X22_13945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3X22_13975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X22_13980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3X22_13985	COG1137	ATPase activity
K3X22_14005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X22_14015	COG0437	4 iron, 4 sulfur cluster binding
K3X22_14020	COG0243	molybdopterin cofactor binding
K3X22_14025	COG0657	acetylesterase activity
K3X22_14060	COG0714	Associated with various cellular activities
K3X22_14070	COG1845	cytochrome c oxidase, subunit III
K3X22_14080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X22_14095	COG2226	methyltransferase
K3X22_14110	COG4263	nitrous-oxide reductase activity
K3X22_14135	COG0437	4 iron, 4 sulfur cluster binding
K3X22_14140	COG0348	domain, Protein
K3X22_14165	COG1999	signal sequence binding
K3X22_14190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3X22_14195	COG3178	'Phosphotransferase
K3X22_14200	COG0802	atpase or kinase
K3X22_14215	COG1999	signal sequence binding
K3X22_14220	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3X22_14240	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3X22_14250	COG1216	Glycosyl transferase, family 2
K3X22_14250	COG1442	glycosyl transferase family 8
K3X22_14260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3X22_14265	COG0133	tryptophan synthase activity
K3X22_14270	COG1652	LysM domain
K3X22_14295	COG2350	Protein conserved in bacteria
K3X22_14300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3X22_14305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3X22_14325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K3X22_14350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X22_14370	COG5598	trimethylamine methyltransferase
K3X22_14375	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X22_14375	COG1902	pentaerythritol trinitrate reductase activity
K3X22_14380	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X22_14380	COG1902	pentaerythritol trinitrate reductase activity
K3X22_14385	COG0129	dihydroxy-acid dehydratase activity
K3X22_14400	COG2175	clavaminate synthase activity
K3X22_14405	COG0583	DNA-binding transcription factor activity
K3X22_14420	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3X22_14435	COG1228	amidohydrolase
K3X22_14440	COG2986	histidine ammonia-lyase
K3X22_14450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K3X22_14455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X22_14465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X22_14470	COG0583	DNA-binding transcription factor activity
K3X22_14475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X22_14485	COG4175	Glycine betaine
K3X22_14485	COG3448	diguanylate cyclase activity
K3X22_14495	COG2267	carboxylic ester hydrolase activity
K3X22_14515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3X22_14520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X22_14525	COG2808	Putative FMN-binding domain
K3X22_14570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3X22_14585	COG1028	Short-chain dehydrogenase reductase Sdr
K3X22_14590	COG0697	spore germination
K3X22_14595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3X22_14600	COG1418	mRNA catabolic process
K3X22_14630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3X22_14635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3X22_14645	COG1960	acyl-CoA dehydrogenase activity
K3X22_14670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3X22_14675	COG0142	geranyltranstransferase activity
K3X22_14680	COG1722	exodeoxyribonuclease VII activity
K3X22_14685	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X22_14700	COG0745	RESPONSE REGULATOR receiver
K3X22_14705	COG1846	Transcriptional regulator
K3X22_14710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3X22_14730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3X22_14740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3X22_14760	COG1968	undecaprenyl-diphosphatase activity
K3X22_14775	COG0564	pseudouridine synthase activity
K3X22_14820	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3X22_14830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3X22_14835	COG1360	Flagellar Motor Protein
K3X22_14840	COG4786	Flagellar basal body rod
K3X22_14855	COG1706	bacterial-type flagellum-dependent cell motility
K3X22_14865	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3X22_14875	COG4786	Flagellar basal body rod
K3X22_14880	COG4786	Flagellar basal body rod
K3X22_14885	COG1987	bacterial-type flagellum assembly
K3X22_14890	COG1677	Flagellar hook-basal body complex protein FliE
K3X22_14895	COG1558	bacterial-type flagellum-dependent cell motility
K3X22_14900	COG1815	bacterial-type flagellum-dependent cell motility
K3X22_14945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3X22_14955	COG2226	methyltransferase
K3X22_14965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3X22_14970	COG1024	Enoyl-CoA hydratase
K3X22_14975	COG0268	Binds directly to 16S ribosomal RNA
K3X22_14990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3X22_15000	COG0698	ribose 5-phosphate isomerase
K3X22_15010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X22_15025	COG1215	transferase activity, transferring glycosyl groups
K3X22_15095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_15100	COG4311	Sarcosine oxidase, delta subunit
K3X22_15105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X22_15105	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X22_15115	COG4977	sequence-specific DNA binding
K3X22_15125	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_15145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X22_15150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X22_15175	COG1450	Type ii and iii secretion system protein
K3X22_15200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X22_15255	COG1280	lysine exporter protein (LysE YggA)
K3X22_15265	COG0745	RESPONSE REGULATOR receiver
K3X22_15275	COG1136	(ABC) transporter
K3X22_15285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3X22_15310	COG0662	Cupin 2, conserved barrel domain protein
K3X22_15325	COG1960	acyl-CoA dehydrogenase activity
K3X22_15330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X22_15335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X22_15345	COG0134	indole-3-glycerol-phosphate synthase activity
K3X22_15445	COG3842	ATPase activity
K3X22_15450	COG3842	ATPase activity
K3X22_15455	COG1175	transmembrane transport
K3X22_15460	COG0395	ABC-type sugar transport system, permease component
K3X22_15500	COG2358	TRAP transporter, solute receptor (TAXI family
K3X22_15510	COG4566	intracellular signal transduction
K3X22_15515	COG1012	belongs to the aldehyde dehydrogenase family
K3X22_15520	COG1960	acyl-CoA dehydrogenase activity
K3X22_15525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X22_15530	COG3800	Transcriptional regulator
K3X22_15530	COG1396	sequence-specific DNA binding
K3X22_15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_15540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X22_15545	COG0174	glutamine synthetase
K3X22_15555	COG1122	ATPase activity
K3X22_15565	COG0310	cobalt ion transport
K3X22_15570	COG0310	cobalt ion transport
K3X22_15580	COG1183	phosphatidylcholine synthase activity
K3X22_15595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3X22_15605	COG1049	propionate catabolic process, 2-methylcitrate cycle
K3X22_15610	COG1522	sequence-specific DNA binding
K3X22_15615	COG0506	proline dehydrogenase activity
K3X22_15615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X22_15615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X22_15625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X22_15635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3X22_15640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X22_15640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X22_15650	COG2226	methyltransferase
K3X22_15655	COG1522	sequence-specific DNA binding
K3X22_15660	COG1473	amidohydrolase
K3X22_15690	COG2351	hydroxyisourate hydrolase activity
K3X22_15695	COG1268	BioY protein
K3X22_15700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X22_15705	COG1122	ATPase activity
K3X22_15710	COG4136	ATPase activity
K3X22_15715	COG4135	transport system, permease component
K3X22_15720	COG4134	Bacterial extracellular solute-binding protein
K3X22_15735	COG1192	Involved in chromosome partitioning
K3X22_15750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X22_15750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X22_15755	COG0509	glycine decarboxylation via glycine cleavage system
K3X22_15760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X22_15770	COG1115	amino acid carrier protein
K3X22_15795	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3X22_15800	COG4149	molybdate abc transporter
K3X22_15805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X22_15820	COG3842	ATPase activity
K3X22_15840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X22_15850	COG2183	response to ionizing radiation
K3X22_15860	COG0010	Belongs to the arginase family