locus-tag	class	description
K3X25_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X25_00040	COG3909	cytochrome
K3X25_00045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X25_00045	COG2010	Cytochrome c
K3X25_00050	COG2132	Multicopper oxidase
K3X25_00080	COG1166	arginine decarboxylase activity
K3X25_00095	COG0010	Belongs to the arginase family
K3X25_00100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3X25_00115	COG2022	thiamine diphosphate biosynthetic process
K3X25_00125	COG0351	phosphomethylpyrimidine kinase
K3X25_00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X25_00150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X25_00155	COG3938	Belongs to the proline racemase family
K3X25_00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_00165	COG3938	Belongs to the proline racemase family
K3X25_00170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X25_00175	COG1802	Transcriptional regulator
K3X25_00185	COG0028	Belongs to the TPP enzyme family
K3X25_00190	COG1349	DNA-binding transcription factor activity
K3X25_00205	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X25_00210	COG3842	ATPase activity
K3X25_00225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3X25_00235	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X25_00265	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3X25_00275	COG0583	DNA-binding transcription factor activity
K3X25_00285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X25_00285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X25_00290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X25_00310	COG0251	oxidation-reduction process
K3X25_00325	COG0745	RESPONSE REGULATOR receiver
K3X25_00330	COG2205	protein histidine kinase activity
K3X25_00350	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
K3X25_00355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X25_00360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X25_00365	COG1960	acyl-CoA dehydrogenase activity
K3X25_00370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X25_00390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3X25_00395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3X25_00400	COG1335	isochorismatase
K3X25_00410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X25_00420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3X25_00430	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3X25_00450	COG0514	ATP-dependent DNA helicase (RecQ)
K3X25_00455	COG3022	response to hydroperoxide
K3X25_00460	COG4999	Histidine kinase
K3X25_00460	COG3850	Histidine kinase
K3X25_00460	COG2205	protein histidine kinase activity
K3X25_00460	COG3437	response regulator, receiver
K3X25_00480	COG0604	alcohol dehydrogenase
K3X25_00480	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_00480	COG3321	synthase
K3X25_00490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3X25_00495	COG2814	Major facilitator Superfamily
K3X25_00505	COG2267	carboxylic ester hydrolase activity
K3X25_00515	COG2423	ornithine cyclodeaminase activity
K3X25_00540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3X25_00620	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3X25_00630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_00630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X25_00635	COG0697	spore germination
K3X25_00640	COG0741	lytic transglycosylase activity
K3X25_00645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X25_00655	COG1720	tRNA m6t6A37 methyltransferase activity
K3X25_00660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3X25_00670	COG0303	'Molybdopterin
K3X25_00675	COG0746	molybdenum cofactor guanylyltransferase activity
K3X25_00680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3X25_00695	COG0583	DNA-binding transcription factor activity
K3X25_00735	COG1960	acyl-CoA dehydrogenase activity
K3X25_00740	COG0009	L-threonylcarbamoyladenylate synthase
K3X25_00745	COG1678	Uncharacterized ACR, COG1678
K3X25_00780	COG3119	arylsulfatase activity
K3X25_00825	COG0494	nUDIX hydrolase
K3X25_00830	COG3034	peptidoglycan biosynthetic process
K3X25_00835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3X25_00850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3X25_00865	COG0328	RNA-DNA hybrid ribonuclease activity
K3X25_00875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3X25_00885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3X25_00890	COG1758	RNA polymerase activity
K3X25_00895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3X25_00905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3X25_00910	COG1280	lysine exporter protein (LysE YggA)
K3X25_00915	COG0736	holo-[acyl-carrier-protein] synthase activity
K3X25_00920	COG0681	Belongs to the peptidase S26 family
K3X25_00925	COG0571	ribonuclease III activity
K3X25_00930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3X25_00940	COG1381	Involved in DNA repair and RecF pathway recombination
K3X25_00980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3X25_00985	COG0745	RESPONSE REGULATOR receiver
K3X25_00990	COG2205	protein histidine kinase activity
K3X25_01000	COG1660	Displays ATPase and GTPase activities
K3X25_01010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X25_01020	COG0840	transmembrane signaling receptor activity
K3X25_01060	COG0300	oxidoreductase activity
K3X25_01070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X25_01080	COG0501	Belongs to the peptidase M48B family
K3X25_01085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X25_01105	COG0250	Participates in transcription elongation, termination and antitermination
K3X25_01110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3X25_01115	COG0081	regulation of translation
K3X25_01120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3X25_01125	COG0222	ribosome binding
K3X25_01130	COG0085	RNA polymerase activity
K3X25_01135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3X25_01145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3X25_01150	COG0049	tRNA binding
K3X25_01155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3X25_01160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X25_01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3X25_01180	COG0088	Forms part of the polypeptide exit tunnel
K3X25_01185	COG0089	rRNA binding
K3X25_01200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3X25_01205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3X25_01210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3X25_01215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3X25_01220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3X25_01260	COG0255	Belongs to the universal ribosomal protein uL29 family
K3X25_01265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3X25_01270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3X25_01275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3X25_01280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3X25_01285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3X25_01290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3X25_01295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3X25_01300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3X25_01305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3X25_01310	COG1841	ribosomal large subunit assembly
K3X25_01315	COG1841	ribosomal large subunit assembly
K3X25_01335	COG0200	Binds to the 23S rRNA
K3X25_01340	COG0201	protein transport
K3X25_01345	COG0563	adenylate kinase activity
K3X25_01350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3X25_01355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3X25_01360	COG0202	RNA polymerase activity
K3X25_01365	COG0203	ribosomal protein L17
K3X25_01375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3X25_01390	COG0564	pseudouridine synthase activity
K3X25_01395	COG0546	phosphoglycolate phosphatase activity
K3X25_01405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X25_01410	COG4597	amino acid ABC transporter
K3X25_01415	COG0765	amino acid transport
K3X25_01420	COG1126	abc transporter atp-binding protein
K3X25_01445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3X25_01450	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_01455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3X25_01465	COG0706	membrane insertase activity
K3X25_01470	COG5001	Diguanylate cyclase
K3X25_01475	COG0037	tRNA processing
K3X25_01490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3X25_01495	COG0594	ribonuclease P activity
K3X25_01500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3X25_01505	COG3734	2-keto-3-deoxy-galactonokinase
K3X25_01530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3X25_01540	COG2885	chlorophyll binding
K3X25_01540	COG3047	cAMP biosynthetic process
K3X25_01560	COG1739	Uncharacterized protein family UPF0029
K3X25_01575	COG1435	thymidine kinase activity
K3X25_01585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X25_01605	COG1136	(ABC) transporter
K3X25_01610	COG0438	transferase activity, transferring glycosyl groups
K3X25_01625	COG0187	DNA topoisomerase II activity
K3X25_01630	COG4335	DNA alkylation repair
K3X25_01635	COG0101	tRNA pseudouridine synthase activity
K3X25_01640	COG3106	COG3106 Predicted ATPase
K3X25_01650	COG3768	UPF0283 membrane protein
K3X25_01675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3X25_01680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3X25_01685	COG1131	(ABC) transporter
K3X25_01690	COG0842	Transport permease protein
K3X25_01695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X25_01695	COG0616	signal peptide processing
K3X25_01715	COG0322	excinuclease ABC activity
K3X25_01720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X25_01730	COG0314	molybdopterin synthase activity
K3X25_01740	COG1183	phosphatidylcholine synthase activity
K3X25_01755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X25_01765	COG2391	methyltransferase activity
K3X25_01775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X25_01780	COG2264	protein methyltransferase activity
K3X25_01805	COG2814	Major facilitator Superfamily
K3X25_01815	COG1045	serine acetyltransferase
K3X25_01820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X25_01830	COG1570	exodeoxyribonuclease VII activity
K3X25_01840	COG0590	tRNA wobble adenosine to inosine editing
K3X25_01860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X25_01865	COG0154	amidase activity
K3X25_01875	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3X25_01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3X25_01900	COG0670	Belongs to the BI1 family
K3X25_01910	COG0583	DNA-binding transcription factor activity
K3X25_01920	COG3321	synthase
K3X25_01920	COG0604	alcohol dehydrogenase
K3X25_01920	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_01930	COG0483	inositol monophosphate 1-phosphatase activity
K3X25_01940	COG0402	S-adenosylhomocysteine deaminase activity
K3X25_01945	COG2239	Acts as a magnesium transporter
K3X25_01950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3X25_01955	COG0471	metal ion transport
K3X25_01955	COG3273	potassium ion transport
K3X25_01960	COG1280	lysine exporter protein (LysE YggA)
K3X25_01970	COG1846	Transcriptional regulator
K3X25_01980	COG0217	transcriptional regulatory protein
K3X25_01990	COG0778	Nitroreductase
K3X25_02005	COG0747	negative chemotaxis
K3X25_02010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3X25_02015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3X25_02020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X25_02060	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_02075	COG0601	transmembrane transport
K3X25_02080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X25_02090	COG4608	Belongs to the ABC transporter superfamily
K3X25_02100	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X25_02100	COG1042	CoA-binding domain protein
K3X25_02100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3X25_02105	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X25_02120	COG0667	Aldo Keto reductase
K3X25_02130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X25_02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X25_02145	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X25_02150	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X25_02155	COG3845	ABC transporter
K3X25_02165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X25_02185	COG2900	Belongs to the SlyX family
K3X25_02190	COG0124	histidyl-tRNA synthetase
K3X25_02195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3X25_02200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3X25_02205	COG0180	Tryptophanyl-tRNA synthetase
K3X25_02220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3X25_02230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3X25_02235	COG0792	nuclease activity
K3X25_02240	COG0189	ligase activity
K3X25_02250	COG0606	chelatase, subunit chli
K3X25_02275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3X25_02280	COG0756	dUTP diphosphatase activity
K3X25_02285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3X25_02300	COG0765	amino acid transport
K3X25_02305	COG0339	signal peptide processing
K3X25_02310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3X25_02375	COG3118	belongs to the thioredoxin family
K3X25_02380	COG0509	glycine decarboxylation via glycine cleavage system
K3X25_02390	COG0534	Mate efflux family protein
K3X25_02400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X25_02430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X25_02450	COG0768	penicillin binding
K3X25_02455	COG0772	Belongs to the SEDS family
K3X25_02495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3X25_02515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X25_02520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3X25_02525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3X25_02530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3X25_02535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3X25_02565	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X25_02565	COG0596	Alpha beta hydrolase
K3X25_02575	COG2983	Belongs to the UPF0260 family
K3X25_02585	COG0196	riboflavin kinase activity
K3X25_02590	COG2030	dehydratase
K3X25_02605	COG1227	inorganic diphosphatase activity
K3X25_02615	COG1858	cytochrome C peroxidase
K3X25_02625	COG0459	protein refolding
K3X25_02640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X25_02645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X25_02670	COG2010	Cytochrome c
K3X25_02675	COG0348	domain, Protein
K3X25_02695	COG2197	response regulator
K3X25_02705	COG4181	ATPase activity
K3X25_02710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3X25_02745	COG2030	dehydratase
K3X25_02755	COG2301	Belongs to the HpcH HpaI aldolase family
K3X25_02770	COG0039	L-malate dehydrogenase activity
K3X25_02780	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X25_02790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K3X25_02795	COG0567	Dehydrogenase, E1 component
K3X25_02800	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X25_02840	COG0642	Histidine kinase
K3X25_02870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3X25_02890	COG0356	it plays a direct role in the translocation of protons across the membrane
K3X25_02895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X25_02900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X25_02905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X25_02915	COG2186	Transcriptional regulator
K3X25_02920	COG2885	chlorophyll binding
K3X25_02930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3X25_02935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X25_02940	COG1765	OsmC-like protein
K3X25_02965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X25_02965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X25_02985	COG3622	Belongs to the hyi family
K3X25_02995	COG0714	Associated with various cellular activities
K3X25_03015	COG0277	FAD linked oxidase domain protein
K3X25_03020	COG0277	FAD linked oxidase domain protein
K3X25_03025	COG0247	lactate metabolic process
K3X25_03035	COG0071	Belongs to the small heat shock protein (HSP20) family
K3X25_03045	COG3191	aminopeptidase activity
K3X25_03055	COG3214	Protein conserved in bacteria
K3X25_03075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X25_03085	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X25_03085	COG0489	protein tyrosine kinase activity
K3X25_03100	COG0254	rRNA binding
K3X25_03105	COG0335	large ribosomal subunit rRNA binding
K3X25_03110	COG0336	Belongs to the RNA methyltransferase TrmD family
K3X25_03120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3X25_03125	COG0778	Nitroreductase
K3X25_03130	COG0228	four-way junction DNA binding
K3X25_03150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3X25_03170	COG1054	Belongs to the UPF0176 family
K3X25_03180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K3X25_03210	COG1309	transcriptional regulator
K3X25_03215	COG3119	arylsulfatase activity
K3X25_03220	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_03235	COG3800	Transcriptional regulator
K3X25_03235	COG1396	sequence-specific DNA binding
K3X25_03240	COG2814	Major facilitator Superfamily
K3X25_03245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X25_03270	COG4770	biotin carboxylase activity
K3X25_03280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X25_03280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X25_03290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X25_03295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3X25_03315	COG0248	Ppx GppA phosphatase
K3X25_03320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3X25_03330	COG0628	permease
K3X25_03345	COG0442	prolyl-tRNA aminoacylation
K3X25_03355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3X25_03360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3X25_03380	COG2046	Belongs to the sulfate adenylyltransferase family
K3X25_03380	COG0529	Catalyzes the synthesis of activated sulfate
K3X25_03390	COG0492	ferredoxin-NADP+ reductase activity
K3X25_03395	COG1522	sequence-specific DNA binding
K3X25_03405	COG1496	oxidoreductase activity
K3X25_03415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X25_03430	COG1573	uracil-dna glycosylase
K3X25_03445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X25_03460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3X25_03470	COG0463	Glycosyl transferase, family 2
K3X25_03515	COG0174	glutamine synthetase
K3X25_03540	COG0022	dehydrogenase e1 component
K3X25_03545	COG0583	DNA-binding transcription factor activity
K3X25_03555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_03560	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_03565	COG0583	DNA-binding transcription factor activity
K3X25_03575	COG0556	nucleotide-excision repair
K3X25_03585	COG2267	carboxylic ester hydrolase activity
K3X25_03595	COG3739	integral membrane protein
K3X25_03605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3X25_03620	COG2204	response regulator
K3X25_03630	COG0280	phosphate acetyltransferase
K3X25_03630	COG0281	malic enzyme
K3X25_03640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3X25_03645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3X25_03650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3X25_03665	COG0318	PFAM AMP-dependent synthetase and ligase
K3X25_03680	COG1024	Enoyl-CoA hydratase
K3X25_03680	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X25_03690	COG0183	Belongs to the thiolase family
K3X25_03695	COG0625	glutathione transferase activity
K3X25_03705	COG1960	acyl-CoA dehydrogenase activity
K3X25_03740	COG0534	Mate efflux family protein
K3X25_03745	COG1393	Belongs to the ArsC family
K3X25_03760	COG3257	ureidoglycine aminohydrolase activity
K3X25_03770	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3X25_03780	COG0737	Belongs to the 5'-nucleotidase family
K3X25_03790	COG2135	peptidase activity
K3X25_03795	COG0154	amidase activity
K3X25_03800	COG0318	PFAM AMP-dependent synthetase and ligase
K3X25_03805	COG0174	glutamine synthetase
K3X25_03810	COG1177	transmembrane transport
K3X25_03815	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X25_03820	COG3842	ATPase activity
K3X25_03850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3X25_03855	COG0602	queuosine metabolic process
K3X25_03860	COG0720	synthase
K3X25_03865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X25_03900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K3X25_03955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X25_04005	COG1196	nuclear chromosome segregation
K3X25_04005	COG0741	lytic transglycosylase activity
K3X25_04005	COG0739	heme binding
K3X25_04010	COG3451	type IV secretory pathway VirB4
K3X25_04025	COG0741	lytic transglycosylase activity
K3X25_04100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3X25_04115	COG1492	cobalamin metabolic process
K3X25_04125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3X25_04135	COG0354	folic acid binding
K3X25_04140	COG1132	(ABC) transporter
K3X25_04155	COG0525	valine-tRNA ligase activity
K3X25_04160	COG0033	Phosphoglucomutase
K3X25_04170	COG0019	diaminopimelate decarboxylase activity
K3X25_04185	COG0583	DNA-binding transcription factor activity
K3X25_04190	COG0483	inositol monophosphate 1-phosphatase activity
K3X25_04215	COG1136	(ABC) transporter
K3X25_04235	COG3842	ATPase activity
K3X25_04245	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X25_04250	COG1177	transmembrane transport
K3X25_04255	COG0740	serine-type endopeptidase activity
K3X25_04260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3X25_04280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3X25_04285	COG0439	Biotin carboxylase
K3X25_04300	COG1309	transcriptional regulator
K3X25_04325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X25_04330	COG0410	ABC transporter
K3X25_04355	COG3800	Transcriptional regulator
K3X25_04355	COG1396	sequence-specific DNA binding
K3X25_04360	COG0745	RESPONSE REGULATOR receiver
K3X25_04370	COG2205	protein histidine kinase activity
K3X25_04380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X25_04395	COG3750	Belongs to the UPF0335 family
K3X25_04400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3X25_04405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3X25_04455	COG0840	transmembrane signaling receptor activity
K3X25_04475	COG0028	Belongs to the TPP enzyme family
K3X25_04480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X25_04490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X25_04495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X25_04495	COG0519	Catalyzes the synthesis of GMP from XMP
K3X25_04525	COG0488	(ABC) transporter
K3X25_04535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3X25_04545	COG0625	glutathione transferase activity
K3X25_04555	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3X25_04565	COG2326	polyphosphate kinase activity
K3X25_04570	COG2951	lytic endotransglycosylase activity
K3X25_04575	COG0534	Mate efflux family protein
K3X25_04625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3X25_04635	COG1278	Cold shock
K3X25_04640	COG1393	Belongs to the ArsC family
K3X25_04660	COG3220	belongs to the UPF0276 family
K3X25_04670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3X25_04685	COG2267	carboxylic ester hydrolase activity
K3X25_04710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3X25_04715	COG0303	'Molybdopterin
K3X25_04720	COG0315	cyclic pyranopterin monophosphate synthase activity
K3X25_04730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3X25_04735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X25_04760	COG0148	phosphopyruvate hydratase activity
K3X25_04775	COG0384	phenazine biosynthesis protein PhzF
K3X25_04790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3X25_04795	COG0456	acetyltransferase
K3X25_04810	COG2081	HI0933 family
K3X25_04815	COG0316	Belongs to the HesB IscA family
K3X25_04820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X25_04825	COG0018	arginyl-trna synthetase
K3X25_04835	COG1472	Belongs to the glycosyl hydrolase 3 family
K3X25_04840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3X25_04845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3X25_04855	COG0717	Belongs to the dCTP deaminase family
K3X25_04870	COG0776	regulation of translation
K3X25_04875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3X25_04880	COG0416	fatty acid biosynthetic process
K3X25_04885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3X25_04900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X25_04910	COG0488	(ABC) transporter
K3X25_04920	COG1272	protein, Hemolysin III
K3X25_04925	COG0076	glutamate decarboxylase activity
K3X25_04930	COG0149	triose-phosphate isomerase activity
K3X25_04935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X25_04940	COG0316	Belongs to the HesB IscA family
K3X25_04955	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X25_04960	COG0343	queuine tRNA-ribosyltransferase activity
K3X25_04970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3X25_04995	COG0406	alpha-ribazole phosphatase activity
K3X25_05020	COG0156	8-amino-7-oxononanoate synthase activity
K3X25_05030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3X25_05040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3X25_05050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_05060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X25_05060	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X25_05105	COG2962	Rard protein
K3X25_05120	COG5265	(ABC) transporter
K3X25_05125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X25_05145	COG1160	GTP binding
K3X25_05165	COG4221	oxidoreductase activity
K3X25_05180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3X25_05205	COG1127	ABC transporter
K3X25_05210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3X25_05215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K3X25_05245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3X25_05265	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3X25_05275	COG0359	binds to the 23S rRNA
K3X25_05280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3X25_05285	COG0360	Binds together with S18 to 16S ribosomal RNA
K3X25_05295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3X25_05305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X25_05310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X25_05315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3X25_05330	COG4695	Portal protein
K3X25_05425	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X25_05430	COG0022	dehydrogenase e1 component
K3X25_05430	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X25_05435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3X25_05445	COG3588	fructose-bisphosphate aldolase
K3X25_05475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X25_05485	COG0436	Aminotransferase
K3X25_05490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3X25_05495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3X25_05505	COG0006	proline dipeptidase activity
K3X25_05510	COG1473	amidohydrolase
K3X25_05520	COG1525	nuclease
K3X25_05545	COG0826	peptidase U32
K3X25_05550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X25_05555	COG0308	aminopeptidase N
K3X25_05560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K3X25_05570	COG2155	Conserved Protein
K3X25_05575	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3X25_05600	COG2010	Cytochrome c
K3X25_05600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X25_05615	COG0436	Aminotransferase
K3X25_05630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3X25_05650	COG1741	Belongs to the pirin family
K3X25_05665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3X25_05680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3X25_05685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3X25_05700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3X25_05705	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3X25_05710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3X25_05715	COG0849	cell division
K3X25_05720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3X25_05725	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3X25_05730	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X25_05740	COG0277	FAD linked oxidase domain protein
K3X25_05745	COG0038	chloride channel
K3X25_05750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X25_05755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3X25_05765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3X25_05780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X25_05795	COG2095	MarC family integral membrane protein
K3X25_05800	COG0488	(ABC) transporter
K3X25_05805	COG0105	UTP biosynthetic process
K3X25_05840	COG0784	Response regulator, receiver
K3X25_05840	COG2198	Histidine kinase
K3X25_05840	COG2205	protein histidine kinase activity
K3X25_05860	COG0730	response to heat
K3X25_05910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3X25_05925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3X25_05935	COG1522	sequence-specific DNA binding
K3X25_05965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X25_05970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X25_05985	COG0433	COG0433 Predicted ATPase
K3X25_05990	COG4536	flavin adenine dinucleotide binding
K3X25_06000	COG0004	ammonium transporteR
K3X25_06045	COG0235	Class ii aldolase
K3X25_06055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3X25_06060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3X25_06065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3X25_06075	COG2166	iron-sulfur cluster assembly
K3X25_06090	COG5012	cobalamin binding
K3X25_06100	COG0646	methionine synthase
K3X25_06100	COG1410	methionine synthase
K3X25_06115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3X25_06120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X25_06125	COG0047	phosphoribosylformylglycinamidine synthase activity
K3X25_06135	COG2204	response regulator
K3X25_06140	COG0457	Tetratricopeptide repeat
K3X25_06145	COG3743	rRNA binding
K3X25_06145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3X25_06150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3X25_06170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3X25_06175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3X25_06180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3X25_06220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3X25_06230	COG2321	neutral zinc metallopeptidase
K3X25_06255	COG0626	cystathionine gamma-synthase activity
K3X25_06315	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3X25_06325	COG1561	YicC-like family, N-terminal region
K3X25_06330	COG0194	GDP metabolic process
K3X25_06345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3X25_06355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3X25_06360	COG2867	negative regulation of translational initiation
K3X25_06365	COG4974	Belongs to the 'phage' integrase family
K3X25_06380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3X25_06385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3X25_06390	COG1058	Belongs to the CinA family
K3X25_06390	COG1546	Belongs to the CinA family
K3X25_06400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X25_06400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3X25_06405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X25_06410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3X25_06415	COG3852	Histidine kinase
K3X25_06420	COG2204	response regulator
K3X25_06425	COG5000	phosphorelay sensor kinase activity
K3X25_06430	COG2204	response regulator
K3X25_06435	COG0569	domain protein
K3X25_06440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X25_06450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3X25_06460	COG2084	Dehydrogenase
K3X25_06480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3X25_06490	COG2814	Major facilitator Superfamily
K3X25_06500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X25_06515	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_06530	COG2313	pseudouridylate synthase activity
K3X25_06535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3X25_06535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3X25_06540	COG0052	Belongs to the universal ribosomal protein uS2 family
K3X25_06545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3X25_06555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3X25_06575	COG0587	DNA-directed DNA polymerase activity
K3X25_06660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_06665	COG4311	Sarcosine oxidase, delta subunit
K3X25_06670	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X25_06670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X25_06680	COG4977	sequence-specific DNA binding
K3X25_06690	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_06710	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X25_06715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X25_06725	COG0824	Thioesterase
K3X25_06725	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X25_06730	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_06735	COG3246	L-lysine catabolic process to acetate
K3X25_06740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X25_06755	COG3831	ATPase activity
K3X25_06760	COG0714	Associated with various cellular activities
K3X25_06770	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K3X25_06780	COG0745	RESPONSE REGULATOR receiver
K3X25_06790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3X25_06800	COG0573	inorganic phosphate transmembrane transporter activity
K3X25_06815	COG5002	protein histidine kinase activity
K3X25_06835	COG5598	trimethylamine methyltransferase
K3X25_06840	COG0519	Catalyzes the synthesis of GMP from XMP
K3X25_06840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X25_06865	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3X25_06870	COG2326	polyphosphate kinase activity
K3X25_06875	COG1309	transcriptional regulator
K3X25_06880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X25_06895	COG0719	Fe-S assembly protein
K3X25_06900	COG0396	ATPase activity
K3X25_06920	COG0719	Fe-S assembly protein
K3X25_06925	COG1104	cysteine desulfurase activity
K3X25_06935	COG1959	2 iron, 2 sulfur cluster binding
K3X25_06940	COG2945	thiolester hydrolase activity
K3X25_06960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3X25_06965	COG1612	heme a metabolic process
K3X25_06970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X25_06980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3X25_06985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X25_06990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3X25_07005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3X25_07010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3X25_07015	COG0745	RESPONSE REGULATOR receiver
K3X25_07025	COG0482	sulfurtransferase activity
K3X25_07035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X25_07045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X25_07050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X25_07060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X25_07070	COG0750	zinc metalloprotease
K3X25_07075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3X25_07085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3X25_07090	COG0233	cytoplasmic translational termination
K3X25_07095	COG0528	UMP kinase activity
K3X25_07105	COG2207	Transcriptional regulator
K3X25_07110	COG0741	lytic transglycosylase activity
K3X25_07115	COG0629	single-stranded DNA binding
K3X25_07135	COG1686	Belongs to the peptidase S11 family
K3X25_07140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3X25_07150	COG0084	hydrolase, TatD family'
K3X25_07175	COG3396	Phenylacetate-CoA oxygenase
K3X25_07180	COG3460	Phenylacetate-CoA oxygenase
K3X25_07185	COG3396	Phenylacetate-CoA oxygenase
K3X25_07190	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X25_07195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3X25_07205	COG2030	dehydratase
K3X25_07205	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_07230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3X25_07245	COG1024	Enoyl-CoA hydratase
K3X25_07250	COG0121	glutamine amidotransferase
K3X25_07260	COG1217	gtp-binding protein TYPA
K3X25_07270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X25_07275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3X25_07290	COG0517	IMP dehydrogenase activity
K3X25_07290	COG0516	GMP reductase activity
K3X25_07315	COG0542	response to heat
K3X25_07335	COG2814	Major facilitator Superfamily
K3X25_07360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X25_07370	COG0129	dihydroxy-acid dehydratase activity
K3X25_07375	COG0800	Aldolase
K3X25_07385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X25_07390	COG0215	cysteine-tRNA ligase activity
K3X25_07475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X25_07480	COG0737	Belongs to the 5'-nucleotidase family
K3X25_07485	COG3258	Cytochrome c
K3X25_07505	COG0785	Cytochrome C biogenesis protein
K3X25_07520	COG2391	methyltransferase activity
K3X25_07545	COG2873	o-acetylhomoserine
K3X25_07550	COG2968	Membrane
K3X25_07560	COG1522	sequence-specific DNA binding
K3X25_07565	COG0840	transmembrane signaling receptor activity
K3X25_07570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3X25_07575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3X25_07580	COG1329	Transcriptional regulator
K3X25_07585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3X25_07590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3X25_07615	COG0166	Belongs to the GPI family
K3X25_07625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3X25_07655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3X25_07665	COG1797	cobyrinic acid a,c-diamide synthase activity
K3X25_07670	COG2814	Major facilitator Superfamily
K3X25_07680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3X25_07700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3X25_07705	COG0028	Belongs to the TPP enzyme family
K3X25_07710	COG0440	acetolactate synthase activity
K3X25_07720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3X25_07740	COG0259	pyridoxamine-phosphate oxidase activity
K3X25_07745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X25_07750	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3X25_07760	COG2890	protein-(glutamine-N5) methyltransferase activity
K3X25_07765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3X25_07775	COG0010	Belongs to the arginase family
K3X25_07780	COG1473	amidohydrolase
K3X25_07785	COG3956	TIGRFAM MazG family protein
K3X25_07790	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X25_07795	COG0494	nUDIX hydrolase
K3X25_07800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3X25_07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3X25_07825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3X25_07835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3X25_07840	COG2833	Protein of unknown function (DUF455)
K3X25_07845	COG0739	heme binding
K3X25_07860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3X25_07865	COG3842	ATPase activity
K3X25_07870	COG0395	ABC-type sugar transport system, permease component
K3X25_07875	COG1175	transmembrane transport
K3X25_07880	COG1653	transport
K3X25_07890	COG0745	RESPONSE REGULATOR receiver
K3X25_07900	COG0835	chemotaxis
K3X25_07905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3X25_07910	COG0745	RESPONSE REGULATOR receiver
K3X25_07930	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3X25_07935	COG2201	protein-glutamate methylesterase activity
K3X25_07940	COG0840	transmembrane signaling receptor activity
K3X25_07950	COG0784	Response regulator, receiver
K3X25_07950	COG2205	protein histidine kinase activity
K3X25_07950	COG5002	protein histidine kinase activity
K3X25_07965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K3X25_08020	COG4964	Belongs to the GSP D family
K3X25_08080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X25_08085	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X25_08085	COG3264	Mechanosensitive ion channel
K3X25_08095	COG0494	nUDIX hydrolase
K3X25_08105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3X25_08110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X25_08115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X25_08130	COG0604	alcohol dehydrogenase
K3X25_08135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X25_08155	COG3738	Protein conserved in bacteria
K3X25_08170	COG0114	fumarate hydratase activity
K3X25_08200	COG0785	Cytochrome C biogenesis protein
K3X25_08205	COG0425	Belongs to the sulfur carrier protein TusA family
K3X25_08210	COG1530	ribonuclease E activity
K3X25_08215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3X25_08220	COG1164	Oligoendopeptidase f
K3X25_08235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X25_08265	COG0564	pseudouridine synthase activity
K3X25_08300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X25_08305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3X25_08345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X25_08345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X25_08355	COG0432	Pfam Uncharacterised protein family UPF0047
K3X25_08375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3X25_08380	COG0358	DNA primase activity
K3X25_08385	COG1309	transcriptional regulator
K3X25_08405	COG1335	isochorismatase
K3X25_08410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3X25_08420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3X25_08430	COG1984	allophanate hydrolase subunit 2
K3X25_08500	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X25_08500	COG0824	Thioesterase
K3X25_08510	COG3246	L-lysine catabolic process to acetate
K3X25_08520	COG0667	Aldo Keto reductase
K3X25_08525	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_08550	COG0513	Belongs to the DEAD box helicase family
K3X25_08560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3X25_08570	COG1007	ATP synthesis coupled electron transport
K3X25_08585	COG0713	ATP synthesis coupled electron transport
K3X25_08600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X25_08605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3X25_08640	COG0649	NAD binding
K3X25_08650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X25_08655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X25_08665	COG1024	Enoyl-CoA hydratase
K3X25_08680	COG4770	biotin carboxylase activity
K3X25_08685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X25_08695	COG1960	acyl-CoA dehydrogenase activity
K3X25_08705	COG0546	phosphoglycolate phosphatase activity
K3X25_08710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3X25_08730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X25_08740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3X25_08745	COG1473	amidohydrolase
K3X25_08750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_08770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3X25_08775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3X25_08780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3X25_08795	COG0275	rRNA processing
K3X25_08800	COG2001	Belongs to the MraZ family
K3X25_08805	COG0489	protein tyrosine kinase activity
K3X25_08815	COG0210	DNA helicase
K3X25_08820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X25_08820	COG1754	DNA topoisomerase type I activity
K3X25_08820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X25_08820	COG1754	DNA topoisomerase type I activity
K3X25_08825	COG0471	metal ion transport
K3X25_08825	COG3273	potassium ion transport
K3X25_08850	COG2226	methyltransferase
K3X25_08860	COG0277	FAD linked oxidase domain protein
K3X25_08865	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_08900	COG4964	Belongs to the GSP D family
K3X25_08955	COG1201	RNA secondary structure unwinding
K3X25_08970	COG1024	Enoyl-CoA hydratase
K3X25_08980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X25_08985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X25_08990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3X25_08995	COG3239	Fatty acid desaturase
K3X25_09005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3X25_09010	COG0037	tRNA processing
K3X25_09020	COG2885	chlorophyll binding
K3X25_09050	COG0824	Thioesterase
K3X25_09065	COG2255	four-way junction helicase activity
K3X25_09070	COG0632	four-way junction helicase activity
K3X25_09080	COG1053	succinate dehydrogenase
K3X25_09090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X25_09105	COG0330	HflC and HflK could
K3X25_09110	COG0330	HflC and HflK could
K3X25_09120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3X25_09125	COG2832	Protein of unknown function (DUF454)
K3X25_09130	COG1760	l-serine dehydratase
K3X25_09155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3X25_09165	COG0504	CTP synthase activity
K3X25_09195	COG4215	(ABC) transporter
K3X25_09205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X25_09205	COG0519	Catalyzes the synthesis of GMP from XMP
K3X25_09210	COG0174	glutamine synthetase
K3X25_09215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X25_09220	COG0583	DNA-binding transcription factor activity
K3X25_09225	COG0658	competence protein
K3X25_09225	COG2333	competence protein COMEC
K3X25_09230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X25_09240	COG1024	Enoyl-CoA hydratase
K3X25_09245	COG3088	subunit of a heme lyase
K3X25_09250	COG1138	Cytochrome C-type biogenesis protein
K3X25_09275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3X25_09280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3X25_09285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K3X25_09300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X25_09305	COG1357	PFAM Pentapeptide repeats (8 copies)
K3X25_09315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3X25_09330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3X25_09335	COG0697	spore germination
K3X25_09340	COG2354	Protein conserved in bacteria
K3X25_09370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3X25_09400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3X25_09405	COG1960	acyl-CoA dehydrogenase activity
K3X25_09410	COG1024	Enoyl-CoA hydratase
K3X25_09430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X25_09435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X25_09440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X25_09455	COG4191	Histidine kinase
K3X25_09460	COG1522	sequence-specific DNA binding
K3X25_09470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3X25_09475	COG0175	sulfate reduction
K3X25_09490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3X25_09505	COG3608	succinylglutamate desuccinylase aspartoacylase
K3X25_09505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3X25_09555	COG0418	dihydroorotase activity
K3X25_09560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X25_09565	COG0305	Participates in initiation and elongation during chromosome replication
K3X25_09585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3X25_09595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X25_09610	COG0300	oxidoreductase activity
K3X25_09615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X25_09625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X25_09630	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X25_09635	COG4133	protoheme IX ABC transporter activity
K3X25_09640	COG3737	Protein of unknown function (DUF498/DUF598)
K3X25_09650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3X25_09655	COG1862	Preprotein translocase
K3X25_09665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3X25_09675	COG0805	protein transport
K3X25_09685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3X25_09695	COG3842	ATPase activity
K3X25_09705	COG0443	Heat shock 70 kDa protein
K3X25_09710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X25_09725	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_09755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X25_09770	COG0659	secondary active sulfate transmembrane transporter activity
K3X25_09775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3X25_09780	COG2311	Membrane
K3X25_09785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3X25_09800	COG0612	Peptidase, M16
K3X25_09820	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3X25_09830	COG0109	protoheme IX farnesyltransferase activity
K3X25_09840	COG0312	modulator of DNA gyrase
K3X25_09855	COG0758	DNA mediated transformation
K3X25_09860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3X25_09890	COG0131	Imidazoleglycerol-phosphate dehydratase
K3X25_09900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3X25_09910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X25_09920	COG0107	imidazoleglycerol-phosphate synthase activity
K3X25_09925	COG0140	phosphoribosyl-ATP diphosphatase activity
K3X25_09940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3X25_09955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X25_09955	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X25_09960	COG3005	denitrification pathway
K3X25_09970	COG0348	domain, Protein
K3X25_09975	COG0437	4 iron, 4 sulfur cluster binding
K3X25_09980	COG0243	molybdopterin cofactor binding
K3X25_09990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3X25_09990	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3X25_10095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3X25_10100	COG1530	ribonuclease E activity
K3X25_10110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3X25_10135	COG5328	Belongs to the UPF0262 family
K3X25_10140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3X25_10150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3X25_10170	COG3916	Acyl-homoserine-lactone synthase
K3X25_10180	COG0318	PFAM AMP-dependent synthetase and ligase
K3X25_10185	COG1132	(ABC) transporter
K3X25_10190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X25_10190	COG0116	Belongs to the methyltransferase superfamily
K3X25_10200	COG2188	Transcriptional regulator
K3X25_10210	COG2267	carboxylic ester hydrolase activity
K3X25_10220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3X25_10225	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_10245	COG0826	peptidase U32
K3X25_10255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3X25_10295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X25_10305	COG1805	sodium ion transport
K3X25_10310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X25_10315	COG1477	protein flavinylation
K3X25_10340	COG0321	lipoyl(octanoyl) transferase activity
K3X25_10345	COG3474	cytochrome
K3X25_10365	COG0505	Belongs to the CarA family
K3X25_10375	COG1802	Transcriptional regulator
K3X25_10410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3X25_10420	COG0697	spore germination
K3X25_10425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3X25_10445	COG0574	Belongs to the PEP-utilizing enzyme family
K3X25_10445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X25_10450	COG0751	glycine-tRNA ligase activity
K3X25_10460	COG0752	glycyl-tRNA synthetase alpha subunit
K3X25_10475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X25_10485	COG1469	GTP cyclohydrolase I activity
K3X25_10495	COG2917	probably involved in intracellular septation
K3X25_10505	COG0552	protein localization to endoplasmic reticulum
K3X25_10535	COG3853	Toxic anion resistance protein (TelA)
K3X25_10560	COG1490	D-aminoacyl-tRNA deacylase activity
K3X25_10570	COG0287	Prephenate dehydrogenase
K3X25_10575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X25_10585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3X25_10605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3X25_10635	COG2197	response regulator
K3X25_10650	COG0444	Belongs to the ABC transporter superfamily
K3X25_10655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X25_10660	COG0601	transmembrane transport
K3X25_10705	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X25_10740	COG0471	metal ion transport
K3X25_10740	COG3273	potassium ion transport
K3X25_10750	COG1692	metallophosphoesterase
K3X25_10755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3X25_10770	COG1744	ABC transporter substrate-binding protein PnrA-like
K3X25_10775	COG3845	ABC transporter
K3X25_10780	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X25_10785	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X25_10805	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_10830	COG0604	alcohol dehydrogenase
K3X25_10835	COG2937	Belongs to the GPAT DAPAT family
K3X25_10840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X25_10840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X25_10850	COG0813	purine-nucleoside phosphorylase activity
K3X25_10860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X25_10860	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X25_10875	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X25_10880	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_10885	COG1960	acyl-CoA dehydrogenase activity
K3X25_10890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X25_10895	COG3800	Transcriptional regulator
K3X25_10895	COG1396	sequence-specific DNA binding
K3X25_10900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X25_10920	COG0625	glutathione transferase activity
K3X25_10995	COG2353	YceI-like domain
K3X25_11005	COG0012	GTP binding
K3X25_11015	COG0159	tryptophan synthase activity
K3X25_11030	COG0513	Belongs to the DEAD box helicase family
K3X25_11055	COG0193	aminoacyl-tRNA hydrolase activity
K3X25_11070	COG0133	tryptophan synthase activity
K3X25_11075	COG0135	phosphoribosylanthranilate isomerase activity
K3X25_11085	COG0776	regulation of translation
K3X25_11090	COG0539	negative regulation of cytoplasmic translation
K3X25_11100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3X25_11120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3X25_11125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3X25_11130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3X25_11135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3X25_11140	COG1253	flavin adenine dinucleotide binding
K3X25_11145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3X25_11150	COG1702	phosphate starvation-inducible protein PhoH
K3X25_11165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X25_11175	COG1047	Peptidyl-prolyl cis-trans
K3X25_11185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X25_11190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X25_11195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X25_11215	COG2267	carboxylic ester hydrolase activity
K3X25_11225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X25_11235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X25_11260	COG2824	Alkylphosphonate utilization operon protein PhnA
K3X25_11275	COG0481	GTPase activity
K3X25_11305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3X25_11315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3X25_11330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3X25_11340	COG1132	(ABC) transporter
K3X25_11345	COG1703	isobutyryl-CoA mutase activity
K3X25_11350	COG1643	Atp-dependent helicase
K3X25_11360	COG0306	phosphate transporter
K3X25_11370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3X25_11375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3X25_11395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X25_11425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3X25_11440	COG0346	lactoylglutathione lyase activity
K3X25_11460	COG0778	Nitroreductase
K3X25_11470	COG1872	DUF167
K3X25_11475	COG3152	Membrane
K3X25_11480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3X25_11510	COG0540	Belongs to the ATCase OTCase family
K3X25_11520	COG1573	uracil-dna glycosylase
K3X25_11525	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3X25_11535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X25_11545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3X25_11565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3X25_11570	COG0142	geranyltranstransferase activity
K3X25_11595	COG0583	DNA-binding transcription factor activity
K3X25_11605	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_11620	COG2818	Glycosylase
K3X25_11625	COG2951	lytic endotransglycosylase activity
K3X25_11640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X25_11645	COG0165	Argininosuccinate lyase
K3X25_11650	COG0019	diaminopimelate decarboxylase activity
K3X25_11660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3X25_11685	COG1162	GTPase activity
K3X25_11695	COG0737	Belongs to the 5'-nucleotidase family
K3X25_11700	COG2816	NAD+ diphosphatase activity
K3X25_11715	COG3474	cytochrome
K3X25_11720	COG4166	transmembrane transport
K3X25_11725	COG4174	ABC transporter (Permease)
K3X25_11730	COG4239	(ABC) transporter, permease
K3X25_11735	COG4172	Belongs to the ABC transporter superfamily
K3X25_11740	COG1686	Belongs to the peptidase S11 family
K3X25_11745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3X25_11750	COG2813	Specifically methylates the guanine in position
K3X25_11760	COG0408	coproporphyrinogen oxidase activity
K3X25_11770	COG1846	Transcriptional regulator
K3X25_11775	COG0183	Belongs to the thiolase family
K3X25_11780	COG0181	hydroxymethylbilane synthase activity
K3X25_11785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3X25_11795	COG0513	Belongs to the DEAD box helicase family
K3X25_11800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3X25_11815	COG0288	reversible hydration of carbon dioxide
K3X25_11825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X25_11830	COG0791	NLP P60 protein
K3X25_11840	COG2050	protein possibly involved in aromatic compounds catabolism
K3X25_11865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3X25_11880	COG0679	Auxin Efflux Carrier
K3X25_11890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3X25_11895	COG1671	Belongs to the UPF0178 family
K3X25_11905	COG1280	lysine exporter protein (LysE YggA)
K3X25_11910	COG2897	thiosulfate sulfurtransferase activity
K3X25_11925	COG0004	ammonium transporteR
K3X25_11930	COG0347	Belongs to the P(II) protein family
K3X25_11960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X25_11970	COG0584	glycerophosphoryl diester phosphodiesterase
K3X25_11980	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3X25_11990	COG0742	ribosomal rna small subunit methyltransferase
K3X25_11995	COG0024	Methionine aminopeptidase
K3X25_12000	COG1489	DNA binding
K3X25_12005	COG1058	Belongs to the CinA family
K3X25_12005	COG1546	Belongs to the CinA family
K3X25_12025	COG0583	DNA-binding transcription factor activity
K3X25_12035	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X25_12035	COG1902	pentaerythritol trinitrate reductase activity
K3X25_12060	COG1266	CAAX protease self-immunity
K3X25_12065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3X25_12070	COG0285	dihydrofolate synthase activity
K3X25_12085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3X25_12100	COG0686	Belongs to the AlaDH PNT family
K3X25_12110	COG0668	transmembrane transport
K3X25_12115	COG1970	mechanosensitive ion channel activity
K3X25_12125	COG0072	phenylalanine-tRNA ligase activity
K3X25_12125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X25_12140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3X25_12145	COG1595	DNA-templated transcription, initiation
K3X25_12150	COG3795	YCII-related domain
K3X25_12160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3X25_12165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3X25_12175	COG0469	pyruvate kinase activity
K3X25_12200	COG3384	dioxygenase
K3X25_12215	COG4948	Mandelate Racemase Muconate Lactonizing
K3X25_12245	COG0825	malonyl-CoA metabolic process
K3X25_12265	COG2884	Cell division ATP-binding protein ftsE
K3X25_12300	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3X25_12310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X25_12320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X25_12335	COG0284	orotidine-5'-phosphate decarboxylase activity
K3X25_12355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3X25_12370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3X25_12385	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3X25_12405	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X25_12435	COG3383	formate dehydrogenase (NAD+) activity
K3X25_12480	COG0612	Peptidase, M16
K3X25_12485	COG0612	Peptidase, M16
K3X25_12495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3X25_12500	COG0138	bifunctional purine biosynthesis protein purh
K3X25_12520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3X25_12525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3X25_12530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3X25_12535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3X25_12555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3X25_12565	COG1185	polyribonucleotide nucleotidyltransferase activity
K3X25_12585	COG1733	regulation of RNA biosynthetic process
K3X25_12595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3X25_12600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3X25_12610	COG0560	Phosphoserine phosphatase
K3X25_12635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3X25_12665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X25_12670	COG2171	N-acyltransferase activity
K3X25_12710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X25_12715	COG0557	exoribonuclease II activity
K3X25_12720	COG2951	lytic endotransglycosylase activity
K3X25_12740	COG1051	belongs to the nudix hydrolase family
K3X25_12745	COG0793	Belongs to the peptidase S41A family
K3X25_12755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X25_12765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3X25_12770	COG0799	negative regulation of ribosome biogenesis
K3X25_12780	COG3264	Mechanosensitive ion channel
K3X25_12780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X25_12785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3X25_12790	COG0066	3-isopropylmalate dehydratase activity
K3X25_12805	COG0473	3-isopropylmalate dehydrogenase activity
K3X25_12820	COG1960	acyl-CoA dehydrogenase activity
K3X25_12825	COG2329	Antibiotic biosynthesis monooxygenase
K3X25_12835	COG2233	PERMEase
K3X25_12840	COG0277	FAD linked oxidase domain protein
K3X25_12850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X25_12855	COG2186	Transcriptional regulator
K3X25_12860	COG0560	Phosphoserine phosphatase
K3X25_12870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3X25_12875	COG0765	amino acid transport
K3X25_12880	COG1126	abc transporter atp-binding protein
K3X25_12885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X25_12895	COG4608	Belongs to the ABC transporter superfamily
K3X25_12900	COG0444	Belongs to the ABC transporter superfamily
K3X25_12905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X25_12910	COG0601	transmembrane transport
K3X25_12915	COG0747	negative chemotaxis
K3X25_12920	COG1802	Transcriptional regulator
K3X25_12945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X25_12950	COG4172	Belongs to the ABC transporter superfamily
K3X25_12960	COG0601	transmembrane transport
K3X25_12970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X25_12980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X25_13000	COG0798	PFAM Bile acid sodium symporter
K3X25_13005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3X25_13015	COG1349	DNA-binding transcription factor activity
K3X25_13030	COG2010	Cytochrome c
K3X25_13045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3X25_13050	COG2010	Cytochrome c
K3X25_13055	COG3391	amine dehydrogenase activity
K3X25_13060	COG1522	sequence-specific DNA binding
K3X25_13075	COG0535	radical SAM domain protein
K3X25_13090	COG2197	response regulator
K3X25_13100	COG1024	Enoyl-CoA hydratase
K3X25_13130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3X25_13145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3X25_13165	COG1766	The M ring may be actively involved in energy transduction
K3X25_13175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X25_13180	COG1338	Plays a role in the flagellum-specific transport system
K3X25_13185	COG4948	Mandelate Racemase Muconate Lactonizing
K3X25_13195	COG0583	DNA-binding transcription factor activity
K3X25_13200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X25_13205	COG0563	adenylate kinase activity
K3X25_13215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3X25_13220	COG0617	tRNA 3'-terminal CCA addition
K3X25_13220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3X25_13220	COG0517	IMP dehydrogenase activity
K3X25_13230	COG2176	DNA-directed DNA polymerase activity
K3X25_13230	COG5002	protein histidine kinase activity
K3X25_13235	COG0243	molybdopterin cofactor binding
K3X25_13325	COG0183	Belongs to the thiolase family
K3X25_13365	COG1674	ftsk spoiiie
K3X25_13385	COG0154	amidase activity
K3X25_13390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3X25_13410	COG2835	tetraacyldisaccharide 4'-kinase activity
K3X25_13425	COG0708	Exodeoxyribonuclease III
K3X25_13435	COG0789	Transcriptional regulator
K3X25_13445	COG0456	acetyltransferase
K3X25_13450	COG0745	RESPONSE REGULATOR receiver
K3X25_13485	COG0495	leucyl-tRNA aminoacylation
K3X25_13500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X25_13500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_13505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X25_13505	COG3264	Mechanosensitive ion channel
K3X25_13510	COG1024	Enoyl-CoA hydratase
K3X25_13515	COG4221	oxidoreductase activity
K3X25_13520	COG0312	modulator of DNA gyrase
K3X25_13525	COG0483	inositol monophosphate 1-phosphatase activity
K3X25_13530	COG1609	Transcriptional regulator
K3X25_13560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3X25_13565	COG0297	glycogen (starch) synthase activity
K3X25_13575	COG0438	transferase activity, transferring glycosyl groups
K3X25_13600	COG0438	transferase activity, transferring glycosyl groups
K3X25_13625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K3X25_13630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X25_13650	COG0662	Cupin 2, conserved barrel domain protein
K3X25_13650	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3X25_13670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3X25_13690	COG1194	a g-specific adenine glycosylase
K3X25_13700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X25_13705	COG3034	peptidoglycan biosynthetic process
K3X25_13710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3X25_13715	COG0617	tRNA 3'-terminal CCA addition
K3X25_13720	COG0494	nUDIX hydrolase
K3X25_13730	COG0745	RESPONSE REGULATOR receiver
K3X25_13740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X25_13750	COG0137	argininosuccinate synthase activity
K3X25_13765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X25_13770	COG0473	3-isopropylmalate dehydrogenase activity
K3X25_13785	COG0435	Glutathione S-transferase
K3X25_13790	COG0281	malic enzyme
K3X25_13790	COG0280	phosphate acetyltransferase
K3X25_13795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3X25_13800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3X25_13805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K3X25_13810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3X25_13815	COG1420	regulation of RNA biosynthetic process
K3X25_13820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3X25_13825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3X25_13830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X25_13845	COG0357	Ribosomal RNA small subunit methyltransferase G
K3X25_13850	COG0445	tRNA wobble uridine modification
K3X25_13855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3X25_13860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3X25_13865	COG1981	membrane
K3X25_13870	COG0424	maF-like protein
K3X25_13875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X25_13880	COG0237	dephospho-CoA kinase activity
K3X25_13885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3X25_13895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3X25_13900	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3X25_13925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3X25_13930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3X25_13945	COG1040	competence protein
K3X25_13955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3X25_13970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3X25_13990	COG0779	Required for maturation of 30S ribosomal subunits
K3X25_14005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3X25_14015	COG0494	nUDIX hydrolase
K3X25_14020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3X25_14025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3X25_14030	COG0653	protein targeting
K3X25_14040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K3X25_14045	COG2003	Belongs to the UPF0758 family
K3X25_14050	COG0484	heat shock protein binding
K3X25_14055	COG0443	Heat shock 70 kDa protein
K3X25_14075	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3X25_14080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3X25_14110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X25_14115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3X25_14120	COG1137	ATPase activity
K3X25_14140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X25_14150	COG0437	4 iron, 4 sulfur cluster binding
K3X25_14155	COG0243	molybdopterin cofactor binding
K3X25_14160	COG0657	acetylesterase activity
K3X25_14170	COG1663	tetraacyldisaccharide 4'-kinase activity
K3X25_14195	COG0714	Associated with various cellular activities
K3X25_14205	COG1845	cytochrome c oxidase, subunit III
K3X25_14215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X25_14230	COG2226	methyltransferase
K3X25_14245	COG4263	nitrous-oxide reductase activity
K3X25_14270	COG0437	4 iron, 4 sulfur cluster binding
K3X25_14275	COG0348	domain, Protein
K3X25_14300	COG1999	signal sequence binding
K3X25_14325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3X25_14330	COG3178	'Phosphotransferase
K3X25_14335	COG0802	atpase or kinase
K3X25_14350	COG1999	signal sequence binding
K3X25_14355	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3X25_14375	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3X25_14385	COG1442	glycosyl transferase family 8
K3X25_14385	COG1216	Glycosyl transferase, family 2
K3X25_14395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3X25_14400	COG0133	tryptophan synthase activity
K3X25_14405	COG1652	LysM domain
K3X25_14435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3X25_14440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3X25_14460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K3X25_14520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X25_14540	COG5598	trimethylamine methyltransferase
K3X25_14545	COG1902	pentaerythritol trinitrate reductase activity
K3X25_14545	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X25_14550	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X25_14550	COG1902	pentaerythritol trinitrate reductase activity
K3X25_14555	COG0129	dihydroxy-acid dehydratase activity
K3X25_14565	COG2175	clavaminate synthase activity
K3X25_14585	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3X25_14600	COG1228	amidohydrolase
K3X25_14605	COG2986	histidine ammonia-lyase
K3X25_14620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X25_14630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X25_14645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3X25_14650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X25_14655	COG2808	Putative FMN-binding domain
K3X25_14700	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3X25_14715	COG1028	Short-chain dehydrogenase reductase Sdr
K3X25_14720	COG0697	spore germination
K3X25_14725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3X25_14730	COG1418	mRNA catabolic process
K3X25_14750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3X25_14755	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3X25_14765	COG1960	acyl-CoA dehydrogenase activity
K3X25_14790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3X25_14795	COG0142	geranyltranstransferase activity
K3X25_14800	COG1722	exodeoxyribonuclease VII activity
K3X25_14805	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X25_14815	COG0745	RESPONSE REGULATOR receiver
K3X25_14820	COG1846	Transcriptional regulator
K3X25_14825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3X25_14845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3X25_14855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3X25_14875	COG1968	undecaprenyl-diphosphatase activity
K3X25_14890	COG0564	pseudouridine synthase activity
K3X25_14935	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3X25_14940	COG0625	glutathione transferase activity
K3X25_14945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3X25_14950	COG1360	Flagellar Motor Protein
K3X25_14955	COG4786	Flagellar basal body rod
K3X25_14970	COG1706	bacterial-type flagellum-dependent cell motility
K3X25_14980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3X25_14990	COG4786	Flagellar basal body rod
K3X25_14995	COG4786	Flagellar basal body rod
K3X25_15000	COG1987	bacterial-type flagellum assembly
K3X25_15005	COG1677	Flagellar hook-basal body complex protein FliE
K3X25_15010	COG1558	bacterial-type flagellum-dependent cell motility
K3X25_15060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3X25_15070	COG2226	methyltransferase
K3X25_15080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3X25_15085	COG1024	Enoyl-CoA hydratase
K3X25_15090	COG0268	Binds directly to 16S ribosomal RNA
K3X25_15105	COG1280	lysine exporter protein (LysE YggA)
K3X25_15115	COG0745	RESPONSE REGULATOR receiver
K3X25_15125	COG1136	(ABC) transporter
K3X25_15135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3X25_15150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X25_15150	COG4191	Histidine kinase
K3X25_15160	COG0662	Cupin 2, conserved barrel domain protein
K3X25_15175	COG1960	acyl-CoA dehydrogenase activity
K3X25_15180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X25_15185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X25_15190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X25_15195	COG0134	indole-3-glycerol-phosphate synthase activity
K3X25_15255	COG3842	ATPase activity
K3X25_15260	COG3842	ATPase activity
K3X25_15265	COG1175	transmembrane transport
K3X25_15270	COG0395	ABC-type sugar transport system, permease component
K3X25_15310	COG2358	TRAP transporter, solute receptor (TAXI family
K3X25_15320	COG4566	intracellular signal transduction
K3X25_15325	COG1012	belongs to the aldehyde dehydrogenase family
K3X25_15330	COG1960	acyl-CoA dehydrogenase activity
K3X25_15335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X25_15340	COG3800	Transcriptional regulator
K3X25_15340	COG1396	sequence-specific DNA binding
K3X25_15345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_15350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X25_15355	COG0174	glutamine synthetase
K3X25_15365	COG1122	ATPase activity
K3X25_15375	COG0310	cobalt ion transport
K3X25_15380	COG0310	cobalt ion transport
K3X25_15390	COG1183	phosphatidylcholine synthase activity
K3X25_15405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3X25_15415	COG1049	propionate catabolic process, 2-methylcitrate cycle
K3X25_15420	COG1522	sequence-specific DNA binding
K3X25_15425	COG0506	proline dehydrogenase activity
K3X25_15425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X25_15425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X25_15435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X25_15445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3X25_15450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X25_15450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X25_15460	COG2226	methyltransferase
K3X25_15465	COG1522	sequence-specific DNA binding
K3X25_15470	COG1473	amidohydrolase
K3X25_15495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X25_15500	COG2351	hydroxyisourate hydrolase activity
K3X25_15505	COG1268	BioY protein
K3X25_15510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X25_15515	COG1122	ATPase activity
K3X25_15520	COG4136	ATPase activity
K3X25_15525	COG4135	transport system, permease component
K3X25_15530	COG4134	Bacterial extracellular solute-binding protein
K3X25_15545	COG1192	Involved in chromosome partitioning
K3X25_15560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X25_15560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X25_15565	COG0509	glycine decarboxylation via glycine cleavage system
K3X25_15570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X25_15580	COG1115	amino acid carrier protein
K3X25_15605	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3X25_15610	COG4149	molybdate abc transporter
K3X25_15615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X25_15630	COG3842	ATPase activity
K3X25_15650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X25_15660	COG2183	response to ionizing radiation
K3X25_15670	COG0010	Belongs to the arginase family
K3X25_15695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3X25_15705	COG0698	ribose 5-phosphate isomerase
K3X25_15715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X25_15730	COG1215	transferase activity, transferring glycosyl groups
K3X25_15765	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3X25_15895	COG1450	Type ii and iii secretion system protein
K3X25_15920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X25_15925	COG1459	type II secretion system