locus-tag	class	description
HYG86_00010	COG0039	L-malate dehydrogenase activity
HYG86_00015	COG3180	Ammonia monooxygenase
HYG86_00020	COG0405	Gamma-glutamyltransferase
HYG86_00030	COG1012	belongs to the aldehyde dehydrogenase family
HYG86_00035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_00065	COG3328	transposase activity
HYG86_00090	COG3212	peptidase
HYG86_00095	COG1595	DNA-templated transcription, initiation
HYG86_00110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_00130	COG0653	protein targeting
HYG86_00150	COG0242	peptide deformylase activity
HYG86_00175	COG1484	DNA-dependent DNA replication
HYG86_00215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_00250	COG0464	growth
HYG86_00255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG86_00360	COG0740	serine-type endopeptidase activity
HYG86_00370	COG4626	Terminase
HYG86_00370	COG1802	Transcriptional regulator
HYG86_00460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_00460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_00480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG86_00540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYG86_00555	COG4974	Belongs to the 'phage' integrase family
HYG86_00565	COG4974	Belongs to the 'phage' integrase family
HYG86_00590	COG4974	Belongs to the 'phage' integrase family
HYG86_00600	COG4974	Belongs to the 'phage' integrase family
HYG86_00620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_00625	COG0728	peptidoglycan biosynthetic process
HYG86_00630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYG86_00645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYG86_00670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYG86_00675	COG2165	general secretion pathway protein
HYG86_00685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_00730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_00755	COG4974	Belongs to the 'phage' integrase family
HYG86_00765	COG4974	Belongs to the 'phage' integrase family
HYG86_00775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG86_00780	COG0728	peptidoglycan biosynthetic process
HYG86_00790	COG2089	acid synthase
HYG86_00800	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HYG86_00805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG86_00810	COG3562	capsule polysaccharide
HYG86_00820	COG1086	Polysaccharide biosynthesis protein
HYG86_00825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_00850	COG0297	glycogen (starch) synthase activity
HYG86_00855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYG86_00865	COG0482	sulfurtransferase activity
HYG86_00875	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG86_00880	COG3457	Alanine racemase
HYG86_00885	COG0626	cystathionine gamma-synthase activity
HYG86_00890	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HYG86_00915	COG2188	Transcriptional regulator
HYG86_00920	COG3546	catalase activity
HYG86_00930	COG1136	(ABC) transporter
HYG86_00930	COG0577	efflux transmembrane transporter activity
HYG86_00935	COG1136	(ABC) transporter
HYG86_00940	COG0577	efflux transmembrane transporter activity
HYG86_00940	COG1136	(ABC) transporter
HYG86_00970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYG86_00980	COG0156	8-amino-7-oxononanoate synthase activity
HYG86_00990	COG1063	alcohol dehydrogenase
HYG86_01005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_01010	COG2171	N-acyltransferase activity
HYG86_01020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG86_01025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG86_01030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYG86_01040	COG2239	Acts as a magnesium transporter
HYG86_01045	COG0305	Participates in initiation and elongation during chromosome replication
HYG86_01050	COG1484	DNA-dependent DNA replication
HYG86_01060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_01065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG86_01090	COG3852	Histidine kinase
HYG86_01135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYG86_01140	COG0105	UTP biosynthetic process
HYG86_01165	COG0328	RNA-DNA hybrid ribonuclease activity
HYG86_01185	COG1136	(ABC) transporter
HYG86_01185	COG0577	efflux transmembrane transporter activity
HYG86_01230	COG3279	Response regulator of the LytR AlgR family
HYG86_01235	COG3290	protein histidine kinase activity
HYG86_01240	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG86_01250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_01260	COG1704	LemA family
HYG86_01285	COG0577	efflux transmembrane transporter activity
HYG86_01285	COG1136	(ABC) transporter
HYG86_01290	COG2205	protein histidine kinase activity
HYG86_01290	COG0784	Response regulator, receiver
HYG86_01295	COG0745	RESPONSE REGULATOR receiver
HYG86_01300	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_01320	COG0704	Plays a role in the regulation of phosphate uptake
HYG86_01330	COG0581	inorganic phosphate transmembrane transporter activity
HYG86_01335	COG0573	inorganic phosphate transmembrane transporter activity
HYG86_01340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYG86_01355	COG0613	PHP domain protein
HYG86_01360	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_01400	COG3344	reverse transcriptase
HYG86_01440	COG1131	(ABC) transporter
HYG86_01450	COG1595	DNA-templated transcription, initiation
HYG86_01460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYG86_01465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYG86_01470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG86_01475	COG1160	GTP binding
HYG86_01515	COG1304	FMN binding
HYG86_01520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG86_01520	COG0539	negative regulation of cytoplasmic translation
HYG86_01530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG86_01545	COG2813	Specifically methylates the guanine in position
HYG86_01555	COG1120	ATPase activity
HYG86_01560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_01570	COG0751	glycine-tRNA ligase activity
HYG86_01585	COG1381	Involved in DNA repair and RecF pathway recombination
HYG86_01590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYG86_01600	COG3879	Bacterial protein of unknown function (DUF881)
HYG86_01605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYG86_01610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYG86_01615	COG1480	7TM receptor with intracellular HD hydrolase
HYG86_01620	COG1702	phosphate starvation-inducible protein PhoH
HYG86_01640	COG4864	UPF0365 protein
HYG86_01645	COG1030	water channel activity
HYG86_01650	COG1610	YqeY-like protein
HYG86_01660	COG0537	adenosine 5'-monophosphoramidase activity
HYG86_01670	COG0537	adenosine 5'-monophosphoramidase activity
HYG86_01680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_01685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYG86_01690	COG2264	protein methyltransferase activity
HYG86_01695	COG0484	heat shock protein binding
HYG86_01700	COG0443	Heat shock 70 kDa protein
HYG86_01710	COG1420	regulation of RNA biosynthetic process
HYG86_01715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG86_01720	COG0481	GTPase activity
HYG86_01745	COG0268	Binds directly to 16S ribosomal RNA
HYG86_01755	COG2333	competence protein COMEC
HYG86_01755	COG0658	competence protein
HYG86_01765	COG3773	Cell wall hydrolase
HYG86_01765	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_01770	COG0243	molybdopterin cofactor binding
HYG86_01775	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG86_01780	COG1555	photosystem II stabilization
HYG86_01780	COG1596	polysaccharide export
HYG86_01795	COG2226	methyltransferase
HYG86_01800	COG0799	negative regulation of ribosome biogenesis
HYG86_01815	COG1534	Rna-binding protein
HYG86_01820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG86_01830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYG86_01840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYG86_01860	COG1994	Peptidase M50
HYG86_01875	COG0772	Belongs to the SEDS family
HYG86_01880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HYG86_01885	COG2894	cell division
HYG86_01890	COG0850	regulation of cytokinetic process
HYG86_01895	COG0768	penicillin binding
HYG86_01905	COG1792	Involved in formation and maintenance of cell shape
HYG86_01910	COG1077	Cell shape determining protein MreB Mrl
HYG86_01915	COG2003	Belongs to the UPF0758 family
HYG86_01920	COG0424	maF-like protein
HYG86_01945	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYG86_01950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYG86_01950	COG2111	Na H antiporter
HYG86_01955	COG0651	ATP synthesis coupled electron transport
HYG86_01960	COG0651	ATP synthesis coupled electron transport
HYG86_01970	COG2111	Na H antiporter
HYG86_01985	COG1320	monovalent cation:proton antiporter activity
HYG86_01990	COG2212	antiporter activity
HYG86_01995	COG1863	multisubunit Na H antiporter MnhE subunit
HYG86_02000	COG2878	Part of a membrane complex involved in electron transport
HYG86_02000	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG86_02005	COG4657	Part of a membrane complex involved in electron transport
HYG86_02010	COG4660	Part of a membrane complex involved in electron transport
HYG86_02015	COG1053	succinate dehydrogenase
HYG86_02015	COG0431	NADPH-dependent FMN reductase
HYG86_02015	COG3976	FMN-binding domain protein
HYG86_02020	COG4658	electron transport chain
HYG86_02025	COG4656	Part of a membrane complex involved in electron transport
HYG86_02030	COG1027	Aspartate ammonia-lyase
HYG86_02035	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYG86_02055	COG5002	protein histidine kinase activity
HYG86_02065	COG0587	DNA-directed DNA polymerase activity
HYG86_02110	COG1122	ATPase activity
HYG86_02125	COG2323	membrane
HYG86_02150	COG0457	Tetratricopeptide repeat
HYG86_02155	COG0285	dihydrofolate synthase activity
HYG86_02160	COG0525	valine-tRNA ligase activity
HYG86_02190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYG86_02200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG86_02205	COG1116	anion transmembrane transporter activity
HYG86_02210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG86_02250	COG0456	acetyltransferase
HYG86_02255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYG86_02260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYG86_02265	COG1067	ATP-dependent peptidase activity
HYG86_02265	COG0470	DNA polymerase III
HYG86_02270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG86_02275	COG0740	serine-type endopeptidase activity
HYG86_02280	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYG86_02340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYG86_02380	COG4865	methylaspartate mutase activity
HYG86_02390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_02400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG86_02405	COG0534	Mate efflux family protein
HYG86_02410	COG1846	Transcriptional regulator
HYG86_02415	COG5002	protein histidine kinase activity
HYG86_02425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_02430	COG5002	protein histidine kinase activity
HYG86_02435	COG0745	RESPONSE REGULATOR receiver
HYG86_02440	COG2201	protein-glutamate methylesterase activity
HYG86_02450	COG0840	transmembrane signaling receptor activity
HYG86_02490	COG0312	modulator of DNA gyrase
HYG86_02495	COG0312	modulator of DNA gyrase
HYG86_02520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_02530	COG0301	tRNA thio-modification
HYG86_02555	COG1533	DNA photolyase activity
HYG86_02565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_02570	COG5002	protein histidine kinase activity
HYG86_02575	COG0745	RESPONSE REGULATOR receiver
HYG86_02585	COG2431	L-lysine efflux transmembrane transporter activity
HYG86_02605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYG86_02615	COG2223	nitrite transmembrane transporter activity
HYG86_02620	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYG86_02625	COG1518	maintenance of DNA repeat elements
HYG86_02675	COG0840	transmembrane signaling receptor activity
HYG86_02675	COG3290	protein histidine kinase activity
HYG86_02680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG86_02690	COG0426	domain, Protein
HYG86_02690	COG1773	rubredoxin
HYG86_02700	COG0824	Thioesterase
HYG86_02715	COG0840	transmembrane signaling receptor activity
HYG86_02720	COG0840	transmembrane signaling receptor activity
HYG86_02730	COG3033	Beta-eliminating lyase
HYG86_02740	COG1408	metallophosphoesterase
HYG86_02760	COG0297	glycogen (starch) synthase activity
HYG86_02765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG86_02770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYG86_02775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG86_02780	COG0626	cystathionine gamma-synthase activity
HYG86_02785	COG1854	S-ribosylhomocysteine lyase activity
HYG86_02790	COG2226	methyltransferase
HYG86_02810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_02810	COG2199	diguanylate cyclase activity
HYG86_02820	COG1032	radical SAM domain protein
HYG86_02840	COG0493	'glutamate synthase
HYG86_02855	COG0697	spore germination
HYG86_02875	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_02895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYG86_02900	COG0534	Mate efflux family protein
HYG86_02905	COG3679	Belongs to the UPF0342 family
HYG86_02910	COG0667	Aldo Keto reductase
HYG86_02915	COG1757	Na H antiporter
HYG86_02925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_02930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG86_02935	COG1328	CTP reductase activity
HYG86_02950	COG1132	(ABC) transporter
HYG86_02955	COG1132	(ABC) transporter
HYG86_02960	COG1592	Rubrerythrin
HYG86_02965	COG0285	dihydrofolate synthase activity
HYG86_02970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_02975	COG1773	rubredoxin
HYG86_02990	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYG86_03010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYG86_03015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYG86_03020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYG86_03035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_03045	COG3842	ATPase activity
HYG86_03050	COG1178	ABC-type Fe3 transport system permease component
HYG86_03060	COG0668	transmembrane transport
HYG86_03065	COG1473	amidohydrolase
HYG86_03090	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HYG86_03095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYG86_03105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYG86_03115	COG2267	carboxylic ester hydrolase activity
HYG86_03130	COG0456	acetyltransferase
HYG86_03160	COG0277	FAD linked oxidase domain protein
HYG86_03165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG86_03170	COG2086	electron transfer activity
HYG86_03175	COG3875	lactate racemase activity
HYG86_03180	COG2186	Transcriptional regulator
HYG86_03185	COG1620	l-lactate permease
HYG86_03190	COG0745	RESPONSE REGULATOR receiver
HYG86_03195	COG5002	protein histidine kinase activity
HYG86_03195	COG3850	Histidine kinase
HYG86_03200	COG1228	amidohydrolase
HYG86_03205	COG1228	amidohydrolase
HYG86_03230	COG4537	Required for transformation and DNA binding
HYG86_03235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYG86_03255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_03260	COG2274	protein secretion by the type I secretion system
HYG86_03285	COG1132	(ABC) transporter
HYG86_03295	COG1132	(ABC) transporter
HYG86_03305	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HYG86_03310	COG1120	ATPase activity
HYG86_03315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_03325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG86_03335	COG1492	cobalamin metabolic process
HYG86_03345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYG86_03350	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYG86_03365	COG1797	cobyrinic acid a,c-diamide synthase activity
HYG86_03370	COG1164	Oligoendopeptidase f
HYG86_03380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYG86_03385	COG0351	phosphomethylpyrimidine kinase
HYG86_03395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_03400	COG0427	acetyl-CoA hydrolase
HYG86_03415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYG86_03445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_03450	COG2030	dehydratase
HYG86_03460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG86_03465	COG2086	electron transfer activity
HYG86_03470	COG1960	acyl-CoA dehydrogenase activity
HYG86_03475	COG0183	Belongs to the thiolase family
HYG86_03480	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYG86_03485	COG1024	Enoyl-CoA hydratase
HYG86_03500	COG1695	Transcriptional regulator
HYG86_03510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_03525	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HYG86_03530	COG4770	biotin carboxylase activity
HYG86_03540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG86_03545	COG0346	lactoylglutathione lyase activity
HYG86_03550	COG1703	isobutyryl-CoA mutase activity
HYG86_03555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_03555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_03560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_03560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_03570	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG86_03575	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_03575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_03595	COG0494	nUDIX hydrolase
HYG86_03605	COG0733	neurotransmitter:sodium symporter activity
HYG86_03610	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HYG86_03615	COG2364	Membrane
HYG86_03620	COG3459	Glycosyltransferase 36 associated
HYG86_03625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYG86_03650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_03655	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HYG86_03720	COG1063	alcohol dehydrogenase
HYG86_03735	COG0702	epimerase
HYG86_03740	COG1846	Transcriptional regulator
HYG86_03760	COG1131	(ABC) transporter
HYG86_03765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG86_03790	COG2502	aspartate--ammonia ligase
HYG86_03795	COG1592	Rubrerythrin
HYG86_03795	COG1773	rubredoxin
HYG86_03820	COG2197	response regulator
HYG86_03825	COG4585	Histidine kinase
HYG86_03830	COG1053	succinate dehydrogenase
HYG86_03835	COG1876	peptidase activity
HYG86_03840	COG0840	transmembrane signaling receptor activity
HYG86_03845	COG0456	acetyltransferase
HYG86_03850	COG0488	(ABC) transporter
HYG86_03865	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_03875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYG86_03900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03905	COG0561	phosphatase activity
HYG86_03910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_03930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_03940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_03950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_03950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_03950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_03955	COG1486	melibiose metabolic process
HYG86_03960	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG86_03965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_03970	COG1486	melibiose metabolic process
HYG86_03995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_04000	COG0561	phosphatase activity
HYG86_04015	COG4656	Part of a membrane complex involved in electron transport
HYG86_04030	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG86_04045	COG4869	propanediol catabolic process
HYG86_04095	COG2207	Transcriptional regulator
HYG86_04095	COG4753	response regulator
HYG86_04100	COG2972	Histidine kinase
HYG86_04120	COG1902	pentaerythritol trinitrate reductase activity
HYG86_04120	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG86_04130	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HYG86_04145	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG86_04150	COG1129	ABC transporter
HYG86_04155	COG1609	Transcriptional regulator
HYG86_04160	COG4214	carbohydrate transport
HYG86_04170	COG4213	ABC transporter substrate-binding protein
HYG86_04175	COG4213	ABC transporter substrate-binding protein
HYG86_04180	COG2207	Transcriptional regulator
HYG86_04180	COG4753	response regulator
HYG86_04185	COG3275	phosphorelay sensor kinase activity
HYG86_04210	COG0768	penicillin binding
HYG86_04240	COG4536	flavin adenine dinucleotide binding
HYG86_04270	COG1940	carbohydrate kinase activity
HYG86_04275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG86_04285	COG1278	Cold shock
HYG86_04290	COG1278	Cold shock
HYG86_04295	COG0110	maltose O-acetyltransferase activity
HYG86_04300	COG3711	transcriptional antiterminator
HYG86_04305	COG1263	PTS System
HYG86_04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_04305	COG2190	(PTS) system
HYG86_04315	COG3870	Protein conserved in bacteria
HYG86_04330	COG1737	Transcriptional regulator
HYG86_04335	COG2723	6-phospho-beta-galactosidase activity
HYG86_04340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_04355	COG1595	DNA-templated transcription, initiation
HYG86_04365	COG2207	Transcriptional regulator
HYG86_04365	COG3708	Transcriptional regulator
HYG86_04390	COG0561	phosphatase activity
HYG86_04400	COG1408	metallophosphoesterase
HYG86_04415	COG5002	protein histidine kinase activity
HYG86_04420	COG0745	RESPONSE REGULATOR receiver
HYG86_04430	COG2801	Transposase and inactivated derivatives
HYG86_04435	COG3328	transposase activity
HYG86_04450	COG5002	protein histidine kinase activity
HYG86_04485	COG4279	zinc finger
HYG86_04490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYG86_04495	COG1406	Chemotaxis phosphatase CheX
HYG86_04530	COG3328	transposase activity
HYG86_04560	COG3328	transposase activity
HYG86_04585	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYG86_04590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYG86_04595	COG0732	type I restriction modification DNA specificity domain
HYG86_04615	COG1121	(ABC) transporter
HYG86_04675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_04675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_04770	COG1802	Transcriptional regulator
HYG86_04770	COG4626	Terminase
HYG86_04775	COG4695	Portal protein
HYG86_04895	COG0653	protein targeting
HYG86_04970	COG0456	acetyltransferase
HYG86_04995	COG3173	Aminoglycoside phosphotransferase
HYG86_05000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG86_05030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_05055	COG0789	Transcriptional regulator
HYG86_05075	COG2207	Transcriptional regulator
HYG86_05075	COG3708	Transcriptional regulator
HYG86_05095	COG5658	integral membrane protein
HYG86_05125	COG0488	(ABC) transporter
HYG86_05135	COG0840	transmembrane signaling receptor activity
HYG86_05145	COG5646	InterPro IPR014922
HYG86_05155	COG1131	(ABC) transporter
HYG86_05195	COG1595	DNA-templated transcription, initiation
HYG86_05205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HYG86_05210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG86_05220	COG1368	sulfuric ester hydrolase activity
HYG86_05280	COG1070	Carbohydrate kinase
HYG86_05285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYG86_05320	COG1307	EDD domain protein, DegV family
HYG86_05360	COG1668	transmembrane transport
HYG86_05365	COG4152	abc transporter atp-binding protein
HYG86_05390	COG1120	ATPase activity
HYG86_05395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_05400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_05405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG86_05450	COG3655	Transcriptional regulator
HYG86_05475	COG2207	Transcriptional regulator
HYG86_05475	COG3708	Transcriptional regulator
HYG86_05480	COG0840	transmembrane signaling receptor activity
HYG86_05495	COG0450	alkyl hydroperoxide reductase
HYG86_05505	COG1357	PFAM Pentapeptide repeats (8 copies)
HYG86_05520	COG3976	FMN-binding domain protein
HYG86_05520	COG1053	succinate dehydrogenase
HYG86_05520	COG0431	NADPH-dependent FMN reductase
HYG86_05525	COG1309	transcriptional regulator
HYG86_05550	COG4604	ABC transporter, ATP-binding protein
HYG86_05555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_05565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYG86_05570	COG0375	protein maturation
HYG86_05595	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HYG86_05610	COG1177	transmembrane transport
HYG86_05615	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYG86_05620	COG3842	ATPase activity
HYG86_05645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYG86_05675	COG3153	acetyltransferase
HYG86_05680	COG0084	hydrolase, TatD family'
HYG86_05685	COG2378	regulation of single-species biofilm formation
HYG86_05710	COG1982	Orn Lys Arg decarboxylase major
HYG86_05790	COG3328	transposase activity
HYG86_05830	COG5002	protein histidine kinase activity
HYG86_05835	COG0745	RESPONSE REGULATOR receiver
HYG86_05840	COG1136	(ABC) transporter
HYG86_05845	COG0577	efflux transmembrane transporter activity
HYG86_05855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_05860	COG1301	dicarboxylic acid transport
HYG86_05875	COG1395	domain, Protein
HYG86_05925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG86_06030	COG4974	Belongs to the 'phage' integrase family
HYG86_06040	COG4974	Belongs to the 'phage' integrase family
HYG86_06125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYG86_06130	COG0557	exoribonuclease II activity
HYG86_06145	COG0288	reversible hydration of carbon dioxide
HYG86_06155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYG86_06160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG86_06175	COG0148	phosphopyruvate hydratase activity
HYG86_06180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYG86_06185	COG0149	triose-phosphate isomerase activity
HYG86_06190	COG0126	phosphoglycerate kinase activity
HYG86_06200	COG2390	Transcriptional regulator
HYG86_06210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYG86_06215	COG0254	rRNA binding
HYG86_06220	COG1481	regulation of sporulation
HYG86_06225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYG86_06240	COG1940	carbohydrate kinase activity
HYG86_06260	COG1307	EDD domain protein, DegV family
HYG86_06265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HYG86_06270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HYG86_06275	COG3639	organic phosphonate transmembrane transporter activity
HYG86_06280	COG3118	belongs to the thioredoxin family
HYG86_06295	COG1653	transport
HYG86_06315	COG0438	transferase activity, transferring glycosyl groups
HYG86_06320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYG86_06325	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HYG86_06335	COG2801	Transposase and inactivated derivatives
HYG86_06345	COG1950	PFAM Membrane protein of
HYG86_06355	COG2340	Cysteine-rich secretory protein family
HYG86_06365	COG2197	response regulator
HYG86_06385	COG0390	transport system, permease component
HYG86_06390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG86_06395	COG4608	Belongs to the ABC transporter superfamily
HYG86_06400	COG0444	Belongs to the ABC transporter superfamily
HYG86_06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_06415	COG0747	negative chemotaxis
HYG86_06425	COG1132	(ABC) transporter
HYG86_06430	COG1132	(ABC) transporter
HYG86_06465	COG0322	excinuclease ABC activity
HYG86_06470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG86_06475	COG0556	nucleotide-excision repair
HYG86_06485	COG0793	Belongs to the peptidase S41A family
HYG86_06485	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_06490	COG0739	heme binding
HYG86_06490	COG0741	lytic transglycosylase activity
HYG86_06490	COG1196	nuclear chromosome segregation
HYG86_06495	COG2177	Part of the ABC transporter FtsEX involved in
HYG86_06500	COG2884	Cell division ATP-binding protein ftsE
HYG86_06510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HYG86_06510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HYG86_06520	COG3958	Transketolase
HYG86_06525	COG3959	Transketolase, thiamine diphosphate binding domain
HYG86_06530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG86_06545	COG0653	protein targeting
HYG86_06555	COG1983	PspC domain protein
HYG86_06565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYG86_06570	COG0840	transmembrane signaling receptor activity
HYG86_06580	COG0438	transferase activity, transferring glycosyl groups
HYG86_06585	COG0463	Glycosyl transferase, family 2
HYG86_06585	COG0457	Tetratricopeptide repeat
HYG86_06595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_06600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_06610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYG86_06615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYG86_06625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYG86_06630	COG1334	flagellar protein FlaG
HYG86_06645	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYG86_06650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG86_06655	COG4786	Flagellar basal body rod
HYG86_06655	COG1256	bacterial-type flagellum assembly
HYG86_06665	COG2747	anti-sigma28 factor FlgM
HYG86_06675	COG1040	competence protein
HYG86_06700	COG2203	Gaf domain
HYG86_06700	COG2199	diguanylate cyclase activity
HYG86_06705	COG2199	diguanylate cyclase activity
HYG86_06705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG86_06710	COG0463	Glycosyl transferase, family 2
HYG86_06715	COG2197	response regulator
HYG86_06720	COG4585	Histidine kinase
HYG86_06725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG86_06730	COG0561	phosphatase activity
HYG86_06735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG86_06740	COG2707	UPF0756 membrane protein
HYG86_06750	COG1473	amidohydrolase
HYG86_06755	COG1773	rubredoxin
HYG86_06755	COG1592	Rubrerythrin
HYG86_06760	COG1592	Rubrerythrin
HYG86_06785	COG0814	amino acid
HYG86_06790	COG0697	spore germination
HYG86_06795	COG1597	lipid kinase activity
HYG86_06810	COG0697	spore germination
HYG86_06820	COG1121	(ABC) transporter
HYG86_06825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG86_06865	COG0697	spore germination
HYG86_06870	COG0436	Aminotransferase
HYG86_06880	COG1164	Oligoendopeptidase f
HYG86_06885	COG1773	rubredoxin
HYG86_06900	COG1131	(ABC) transporter
HYG86_06905	COG0561	phosphatase activity
HYG86_06910	COG0745	RESPONSE REGULATOR receiver
HYG86_06915	COG5002	protein histidine kinase activity
HYG86_06925	COG0517	IMP dehydrogenase activity
HYG86_06925	COG0617	tRNA 3'-terminal CCA addition
HYG86_06925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_06935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG86_06945	COG0668	transmembrane transport
HYG86_06950	COG1489	DNA binding
HYG86_06960	COG0488	(ABC) transporter
HYG86_06970	COG0438	transferase activity, transferring glycosyl groups
HYG86_06990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYG86_06995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYG86_07000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG86_07005	COG0456	acetyltransferase
HYG86_07010	COG1214	PFAM Peptidase M22, glycoprotease
HYG86_07015	COG0802	atpase or kinase
HYG86_07065	COG1404	Belongs to the peptidase S8 family
HYG86_07070	COG1162	GTPase activity
HYG86_07075	COG0588	phosphoglycerate mutase activity
HYG86_07095	COG0402	S-adenosylhomocysteine deaminase activity
HYG86_07100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG86_07110	COG2183	response to ionizing radiation
HYG86_07115	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG86_07130	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG86_07135	COG0864	Transcriptional regulator
HYG86_07140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG86_07150	COG0617	tRNA 3'-terminal CCA addition
HYG86_07150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_07150	COG0517	IMP dehydrogenase activity
HYG86_07155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYG86_07155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYG86_07170	COG1505	serine-type exopeptidase activity
HYG86_07175	COG0488	(ABC) transporter
HYG86_07185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG86_07195	COG0367	asparagine synthase
HYG86_07210	COG2362	D-Aminopeptidase
HYG86_07220	COG1136	(ABC) transporter
HYG86_07230	COG1595	DNA-templated transcription, initiation
HYG86_07240	COG0667	Aldo Keto reductase
HYG86_07245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYG86_07250	COG1876	peptidase activity
HYG86_07260	COG2205	protein histidine kinase activity
HYG86_07290	COG2197	response regulator
HYG86_07320	COG2197	response regulator
HYG86_07335	COG1929	Belongs to the glycerate kinase type-1 family
HYG86_07340	COG1132	(ABC) transporter
HYG86_07345	COG1132	(ABC) transporter
HYG86_07365	COG0006	proline dipeptidase activity
HYG86_07370	COG0406	alpha-ribazole phosphatase activity
HYG86_07375	COG4464	protein tyrosine phosphatase activity
HYG86_07405	COG2267	carboxylic ester hydrolase activity
HYG86_07450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG86_07465	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYG86_07470	COG2217	Heavy metal translocating P-type atpase
HYG86_07475	COG0640	Transcriptional regulator
HYG86_07495	COG0170	dolichyl monophosphate biosynthetic process
HYG86_07515	COG1940	carbohydrate kinase activity
HYG86_07520	COG2723	6-phospho-beta-galactosidase activity
HYG86_07525	COG3394	polysaccharide catabolic process
HYG86_07530	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG86_07535	COG1486	melibiose metabolic process
HYG86_07545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_07550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG86_07555	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG86_07555	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG86_07560	COG0019	diaminopimelate decarboxylase activity
HYG86_07565	COG2715	membrane protein required for spore maturation
HYG86_07570	COG0700	Nucleoside recognition
HYG86_07575	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG86_07580	COG1473	amidohydrolase
HYG86_07585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG86_07590	COG1482	cell wall glycoprotein biosynthetic process
HYG86_07595	COG0673	inositol 2-dehydrogenase activity
HYG86_07605	COG4536	flavin adenine dinucleotide binding
HYG86_07625	COG0789	Transcriptional regulator
HYG86_07635	COG1846	Transcriptional regulator
HYG86_07655	COG1136	(ABC) transporter
HYG86_07655	COG0577	efflux transmembrane transporter activity
HYG86_07690	COG1151	hydroxylamine reductase activity
HYG86_07700	COG5566	PFAM Mor transcription activator
HYG86_07705	COG0653	protein targeting
HYG86_07720	COG0564	pseudouridine synthase activity
HYG86_07740	COG1408	metallophosphoesterase
HYG86_07750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYG86_07765	COG1136	(ABC) transporter
HYG86_07770	COG1115	amino acid carrier protein
HYG86_07790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_07800	COG1757	Na H antiporter
HYG86_07815	COG5002	protein histidine kinase activity
HYG86_07825	COG2721	sulfolactate sulfo-lyase activity
HYG86_07830	COG2721	sulfolactate sulfo-lyase activity
HYG86_07845	COG1131	(ABC) transporter
HYG86_07860	COG0006	proline dipeptidase activity
HYG86_07865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG86_07870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG86_07875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG86_07880	COG1473	amidohydrolase
HYG86_07885	COG1414	Transcriptional regulator
HYG86_07920	COG0778	Nitroreductase
HYG86_07930	COG1307	EDD domain protein, DegV family
HYG86_07935	COG1063	alcohol dehydrogenase
HYG86_07945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_07945	COG2213	PTS system mannitol-specific
HYG86_07950	COG3711	transcriptional antiterminator
HYG86_07995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYG86_08000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG86_08005	COG4856	YbbR-like protein
HYG86_08010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYG86_08035	COG2235	arginine
HYG86_08040	COG0010	Belongs to the arginase family
HYG86_08045	COG3457	Alanine racemase
HYG86_08055	COG5012	cobalamin binding
HYG86_08080	COG3829	transcription factor binding
HYG86_08085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYG86_08090	COG0697	spore germination
HYG86_08105	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_08110	COG3973	AAA domain
HYG86_08125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYG86_08130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYG86_08135	COG0101	tRNA pseudouridine synthase activity
HYG86_08140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYG86_08145	COG1122	ATPase activity
HYG86_08150	COG1122	ATPase activity
HYG86_08160	COG0202	RNA polymerase activity
HYG86_08165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG86_08175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYG86_08180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYG86_08195	COG0024	Methionine aminopeptidase
HYG86_08200	COG0563	adenylate kinase activity
HYG86_08205	COG0201	protein transport
HYG86_08215	COG1841	ribosomal large subunit assembly
HYG86_08220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYG86_08225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYG86_08230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYG86_08235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYG86_08240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYG86_08245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYG86_08250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYG86_08260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYG86_08265	COG0255	Belongs to the universal ribosomal protein uL29 family
HYG86_08270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYG86_08275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYG86_08285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYG86_08295	COG0089	rRNA binding
HYG86_08300	COG0088	Forms part of the polypeptide exit tunnel
HYG86_08305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYG86_08310	COG0051	transcription antitermination factor activity, RNA binding
HYG86_08315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG86_08320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG86_08325	COG0049	tRNA binding
HYG86_08330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYG86_08335	COG1358	cellular component organization or biogenesis
HYG86_08340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYG86_08345	COG0085	RNA polymerase activity
HYG86_08355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYG86_08360	COG0081	regulation of translation
HYG86_08365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYG86_08370	COG0250	Participates in transcription elongation, termination and antitermination
HYG86_08375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG86_08380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYG86_08385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG86_08420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG86_08430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HYG86_08435	COG0215	cysteine-tRNA ligase activity
HYG86_08440	COG1045	serine acetyltransferase
HYG86_08445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYG86_08455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG86_08460	COG4956	integral membrane protein (PIN domain superfamily)
HYG86_08465	COG1329	Transcriptional regulator
HYG86_08475	COG1183	phosphatidylcholine synthase activity
HYG86_08480	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HYG86_08485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYG86_08495	COG0542	response to heat
HYG86_08500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYG86_08505	COG3880	PFAM UvrB UvrC protein
HYG86_08520	COG1126	abc transporter atp-binding protein
HYG86_08525	COG0765	amino acid transport
HYG86_08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG86_08540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG86_08545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG86_08615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYG86_08620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYG86_08625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_08625	COG5322	oxidoreductase activity
HYG86_08640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG86_08655	COG1832	CoA-binding protein
HYG86_08665	COG0393	Putative heavy-metal-binding
HYG86_08675	COG1131	(ABC) transporter
HYG86_08680	COG1725	Transcriptional regulator
HYG86_08685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYG86_08690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYG86_08695	COG0157	Belongs to the NadC ModD family
HYG86_08700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYG86_08705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYG86_08715	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYG86_08720	COG1228	amidohydrolase
HYG86_08730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYG86_08735	COG2986	histidine ammonia-lyase
HYG86_08740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_08745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG86_08750	COG0037	tRNA processing
HYG86_08785	COG1098	S1 RNA binding domain
HYG86_08805	COG2385	sporulation resulting in formation of a cellular spore
HYG86_08810	COG0776	regulation of translation
HYG86_08815	COG3956	TIGRFAM MazG family protein
HYG86_08820	COG2244	polysaccharide biosynthetic process
HYG86_08825	COG2002	toxin-antitoxin pair type II binding
HYG86_08835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYG86_08845	COG0517	IMP dehydrogenase activity
HYG86_08845	COG0516	GMP reductase activity
HYG86_08850	COG0193	aminoacyl-tRNA hydrolase activity
HYG86_08855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG86_08860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYG86_08865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_08870	COG2088	sporulation resulting in formation of a cellular spore
HYG86_08875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYG86_08880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_08890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYG86_08895	COG0189	ligase activity
HYG86_08895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_08910	COG1376	ErfK ybiS ycfS ynhG family protein
HYG86_08915	COG2340	Cysteine-rich secretory protein family
HYG86_08935	COG4466	Protein conserved in bacteria
HYG86_08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG86_08960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG86_08965	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYG86_08970	COG0084	hydrolase, TatD family'
HYG86_08975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_08975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_08995	COG2002	toxin-antitoxin pair type II binding
HYG86_09000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYG86_09005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYG86_09010	COG4467	Involved in initiation control of chromosome replication
HYG86_09015	COG1774	PSP1 C-terminal conserved region
HYG86_09025	COG3870	Protein conserved in bacteria
HYG86_09035	COG1982	Orn Lys Arg decarboxylase major
HYG86_09055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYG86_09185	COG3728	DNA packaging
HYG86_09185	COG5484	DNA packaging
HYG86_09240	COG0629	single-stranded DNA binding
HYG86_09245	COG1388	LysM domain
HYG86_09245	COG3584	3D domain protein
HYG86_09355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_09360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_09370	COG0516	GMP reductase activity
HYG86_09370	COG0517	IMP dehydrogenase activity
HYG86_09410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_09440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYG86_09445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYG86_09450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG86_09490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYG86_09495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYG86_09500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG86_09515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYG86_09520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG86_09520	COG1328	CTP reductase activity
HYG86_09525	COG0602	queuosine metabolic process
HYG86_09550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG86_09555	COG0187	DNA topoisomerase II activity
HYG86_09570	COG2501	S4 domain
HYG86_09575	COG0592	DNA-directed DNA polymerase activity
HYG86_09580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYG86_09585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYG86_09590	COG0594	ribonuclease P activity
HYG86_09600	COG0706	membrane insertase activity
HYG86_09605	COG1847	R3H domain protein
HYG86_09610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG86_09615	COG0445	tRNA wobble uridine modification
HYG86_09620	COG0357	Ribosomal RNA small subunit methyltransferase G
HYG86_09630	COG1192	Involved in chromosome partitioning
HYG86_09635	COG1475	DNA binding
HYG86_09645	COG1811	Na channel or pump
HYG86_09650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYG86_09665	COG1196	nuclear chromosome segregation
HYG86_09665	COG0741	lytic transglycosylase activity
HYG86_09665	COG0739	heme binding
HYG86_09685	COG3949	Membrane
HYG86_09715	COG4481	Protein conserved in bacteria
HYG86_09720	COG0360	Binds together with S18 to 16S ribosomal RNA
HYG86_09725	COG0629	single-stranded DNA binding
HYG86_09730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYG86_09750	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_09760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYG86_09785	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG86_09790	COG0791	NLP P60 protein
HYG86_09790	COG1388	LysM domain
HYG86_09800	COG0745	RESPONSE REGULATOR receiver
HYG86_09805	COG5002	protein histidine kinase activity
HYG86_09815	COG4853	Protein conserved in bacteria
HYG86_09825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYG86_09830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG86_09845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYG86_09880	COG2226	methyltransferase
HYG86_09900	COG5002	protein histidine kinase activity
HYG86_09905	COG0745	RESPONSE REGULATOR receiver
HYG86_09915	COG1309	transcriptional regulator
HYG86_09920	COG2814	Major facilitator Superfamily
HYG86_09940	COG0017	Asparaginyl-tRNA synthetase
HYG86_09950	COG2207	Transcriptional regulator
HYG86_09950	COG3708	Transcriptional regulator
HYG86_09955	COG1132	(ABC) transporter
HYG86_09960	COG1132	(ABC) transporter
HYG86_09970	COG2226	methyltransferase
HYG86_09975	COG2884	Cell division ATP-binding protein ftsE
HYG86_09980	COG2177	Part of the ABC transporter FtsEX involved in
HYG86_09995	COG0673	inositol 2-dehydrogenase activity
HYG86_10010	COG0514	ATP-dependent DNA helicase (RecQ)
HYG86_10020	COG0534	Mate efflux family protein
HYG86_10025	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_10030	COG2706	6-phosphogluconolactonase activity
HYG86_10060	COG1132	(ABC) transporter
HYG86_10065	COG1132	(ABC) transporter
HYG86_10070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYG86_10095	COG3871	stress protein (general stress protein 26)
HYG86_10100	COG2814	Major facilitator Superfamily
HYG86_10110	COG0488	(ABC) transporter
HYG86_10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG86_10120	COG0723	plastoquinol--plastocyanin reductase activity
HYG86_10130	COG1187	pseudouridine synthase activity
HYG86_10135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG86_10135	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYG86_10155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG86_10180	COG2323	membrane
HYG86_10200	COG1151	hydroxylamine reductase activity
HYG86_10215	COG1902	pentaerythritol trinitrate reductase activity
HYG86_10220	COG0420	3'-5' exonuclease activity
HYG86_10225	COG4717	serine-type aminopeptidase activity
HYG86_10230	COG0423	glycine-tRNA ligase activity
HYG86_10240	COG0114	fumarate hydratase activity
HYG86_10245	COG1199	ATP-dependent helicase activity
HYG86_10255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG86_10260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_10270	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG86_10275	COG0010	Belongs to the arginase family
HYG86_10290	COG3829	transcription factor binding
HYG86_10295	COG0604	alcohol dehydrogenase
HYG86_10310	COG1193	negative regulation of DNA recombination
HYG86_10315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG86_10320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG86_10325	COG0504	CTP synthase activity
HYG86_10335	COG2204	response regulator
HYG86_10340	COG1494	fructose-1,6-bisphosphatase
HYG86_10345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG86_10350	COG1494	fructose-1,6-bisphosphatase
HYG86_10355	COG0530	calcium, potassium:sodium antiporter activity
HYG86_10360	COG4942	peptidase
HYG86_10380	COG1435	thymidine kinase activity
HYG86_10385	COG3872	metal-dependent enzyme
HYG86_10390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYG86_10395	COG2890	protein-(glutamine-N5) methyltransferase activity
HYG86_10400	COG1191	sigma factor activity
HYG86_10420	COG1959	2 iron, 2 sulfur cluster binding
HYG86_10425	COG1104	cysteine desulfurase activity
HYG86_10430	COG0822	iron-sulfur transferase activity
HYG86_10440	COG0425	Belongs to the sulfur carrier protein TusA family
HYG86_10455	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG86_10460	COG0735	belongs to the Fur family
HYG86_10470	COG0009	L-threonylcarbamoyladenylate synthase
HYG86_10475	COG1971	Probably functions as a manganese efflux pump
HYG86_10485	COG0840	transmembrane signaling receptor activity
HYG86_10490	COG0698	ribose 5-phosphate isomerase
HYG86_10495	COG4475	Protein of unknown function (DUF436)
HYG86_10500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYG86_10505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYG86_10525	COG1607	acyl-coa hydrolase
HYG86_10530	COG3246	L-lysine catabolic process to acetate
HYG86_10555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYG86_10560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG86_10565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYG86_10570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYG86_10575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYG86_10580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYG86_10585	COG5506	Protein of unknown function (DUF1694)
HYG86_10595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG86_10600	COG2385	sporulation resulting in formation of a cellular spore
HYG86_10610	COG1609	Transcriptional regulator
HYG86_10680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG86_10690	COG1496	oxidoreductase activity
HYG86_10695	COG0251	oxidation-reduction process
HYG86_10700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG86_10710	COG3275	phosphorelay sensor kinase activity
HYG86_10715	COG3279	Response regulator of the LytR AlgR family
HYG86_10720	COG1966	Carbon starvation protein
HYG86_10735	COG3118	belongs to the thioredoxin family
HYG86_10775	COG0426	domain, Protein
HYG86_10800	COG0583	DNA-binding transcription factor activity
HYG86_10805	COG0709	Synthesizes selenophosphate from selenide and ATP
HYG86_10815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYG86_10835	COG0303	'Molybdopterin
HYG86_10840	COG1910	domain protein
HYG86_10845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYG86_10850	COG0459	protein refolding
HYG86_10855	COG0714	Associated with various cellular activities
HYG86_10860	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HYG86_10890	COG2801	Transposase and inactivated derivatives
HYG86_10905	COG3177	Filamentation induced by cAMP protein fic
HYG86_10950	COG2190	(PTS) system
HYG86_10960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYG86_10965	COG2252	PERMEase
HYG86_10970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYG86_10975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYG86_10980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_10985	COG0047	phosphoribosylformylglycinamidine synthase activity
HYG86_10990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_10995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYG86_11000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYG86_11005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYG86_11010	COG0138	bifunctional purine biosynthesis protein purh
HYG86_11015	COG0151	Belongs to the GarS family
HYG86_11040	COG0534	Mate efflux family protein
HYG86_11050	COG3829	transcription factor binding
HYG86_11050	COG3290	protein histidine kinase activity
HYG86_11070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_11080	COG2376	Dihydroxyacetone kinase
HYG86_11090	COG1233	COG1233 Phytoene dehydrogenase and related
HYG86_11095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYG86_11115	COG1773	rubredoxin
HYG86_11115	COG1592	Rubrerythrin
HYG86_11130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYG86_11140	COG4496	protein, YerC YecD
HYG86_11145	COG1454	alcohol dehydrogenase
HYG86_11155	COG0210	DNA helicase
HYG86_11160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG86_11190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYG86_11210	COG5002	protein histidine kinase activity
HYG86_11215	COG1136	(ABC) transporter
HYG86_11230	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_11235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYG86_11275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYG86_11280	COG0363	glucosamine-6-phosphate deaminase activity
HYG86_11285	COG1737	Transcriptional regulator
HYG86_11295	COG1263	PTS System
HYG86_11295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_11320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYG86_11325	COG4974	Belongs to the 'phage' integrase family
HYG86_11425	COG1937	Protein conserved in bacteria
HYG86_11430	COG2217	Heavy metal translocating P-type atpase
HYG86_11470	COG0534	Mate efflux family protein
HYG86_11475	COG1937	Protein conserved in bacteria
HYG86_11480	COG1136	(ABC) transporter
HYG86_11485	COG0577	efflux transmembrane transporter activity
HYG86_11535	COG0783	Belongs to the Dps family
HYG86_11540	COG3620	sequence-specific DNA binding
HYG86_11560	COG1132	(ABC) transporter
HYG86_11580	COG0574	Belongs to the PEP-utilizing enzyme family
HYG86_11580	COG3848	Pyruvate phosphate dikinase
HYG86_11585	COG0488	(ABC) transporter
HYG86_11615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG86_11620	COG0805	protein transport
HYG86_11625	COG3976	FMN-binding domain protein
HYG86_11625	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HYG86_11630	COG2391	methyltransferase activity
HYG86_11640	COG2391	methyltransferase activity
HYG86_11645	COG0583	DNA-binding transcription factor activity
HYG86_11670	COG0493	'glutamate synthase
HYG86_11675	COG3279	Response regulator of the LytR AlgR family
HYG86_11700	COG2207	Transcriptional regulator
HYG86_11715	COG3708	Transcriptional regulator
HYG86_11715	COG2207	Transcriptional regulator
HYG86_11725	COG0667	Aldo Keto reductase
HYG86_11755	COG3620	sequence-specific DNA binding
HYG86_11770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG86_11780	COG0813	purine-nucleoside phosphorylase activity
HYG86_11785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYG86_11790	COG1595	DNA-templated transcription, initiation
HYG86_11800	COG1131	(ABC) transporter
HYG86_11820	COG0667	Aldo Keto reductase
HYG86_11830	COG0656	L-ascorbic acid biosynthetic process
HYG86_11840	COG0667	Aldo Keto reductase
HYG86_11860	COG1309	transcriptional regulator
HYG86_11875	COG0789	Transcriptional regulator
HYG86_11880	COG0667	Aldo Keto reductase
HYG86_11885	COG2723	6-phospho-beta-galactosidase activity
HYG86_11915	COG0484	heat shock protein binding
HYG86_11920	COG0840	transmembrane signaling receptor activity
HYG86_11925	COG3326	Membrane
HYG86_11930	COG3973	AAA domain
HYG86_11935	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYG86_11945	COG0346	lactoylglutathione lyase activity
HYG86_11955	COG2268	Band 7 protein
HYG86_11990	COG4895	conserved protein (DUF2196)
HYG86_12000	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG86_12010	COG1476	TRANSCRIPTIONal
HYG86_12035	COG2801	Transposase and inactivated derivatives
HYG86_12040	COG0745	RESPONSE REGULATOR receiver
HYG86_12055	COG2205	protein histidine kinase activity
HYG86_12070	COG4989	oxidoreductase activity
HYG86_12090	COG3437	response regulator, receiver
HYG86_12090	COG0784	Response regulator, receiver
HYG86_12095	COG2169	Transcriptional regulator
HYG86_12100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_12105	COG4605	iron ion homeostasis
HYG86_12110	COG4604	ABC transporter, ATP-binding protein
HYG86_12115	COG4607	ABC-type enterochelin transport system periplasmic component
HYG86_12120	COG2996	Protein conserved in bacteria
HYG86_12135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_12165	COG4946	Tricorn protease homolog
HYG86_12165	COG1506	peptidase
HYG86_12165	COG0823	Involved in the tonB-independent uptake of proteins
HYG86_12170	COG1349	DNA-binding transcription factor activity
HYG86_12185	COG0058	SHG alpha-glucan phosphorylase activity
HYG86_12200	COG1175	transmembrane transport
HYG86_12205	COG3833	ABC-type maltose transport systems, permease component
HYG86_12210	COG3842	ATPase activity
HYG86_12215	COG1609	Transcriptional regulator
HYG86_12235	COG0187	DNA topoisomerase II activity
HYG86_12255	COG0385	Bile acid
HYG86_12260	COG1132	(ABC) transporter
HYG86_12310	COG1309	transcriptional regulator
HYG86_12315	COG1131	(ABC) transporter
HYG86_12330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYG86_12360	COG0384	phenazine biosynthesis protein PhzF
HYG86_12390	COG0012	GTP binding
HYG86_12395	COG1263	PTS System
HYG86_12395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_12400	COG0366	Alpha amylase catalytic
HYG86_12405	COG2188	Transcriptional regulator
HYG86_12415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYG86_12420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_12425	COG1757	Na H antiporter
HYG86_12430	COG2323	membrane
HYG86_12440	COG1725	Transcriptional regulator
HYG86_12445	COG1131	(ABC) transporter
HYG86_12455	COG0693	protein deglycase activity
HYG86_12455	COG0753	catalase activity
HYG86_12460	COG2832	Protein of unknown function (DUF454)
HYG86_12475	COG0626	cystathionine gamma-synthase activity
HYG86_12500	COG3875	lactate racemase activity
HYG86_12505	COG1464	Belongs to the NlpA lipoprotein family
HYG86_12510	COG0436	Aminotransferase
HYG86_12515	COG2011	ABC-type metal ion transport system permease component
HYG86_12520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYG86_12525	COG2909	trisaccharide binding
HYG86_12540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYG86_12545	COG1757	Na H antiporter
HYG86_12570	COG1368	sulfuric ester hydrolase activity
HYG86_12575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HYG86_12645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_12650	COG1132	(ABC) transporter
HYG86_12655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG86_12665	COG4585	Histidine kinase
HYG86_12670	COG2197	response regulator
HYG86_12675	COG1943	Transposase
HYG86_12680	COG1131	(ABC) transporter
HYG86_12700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG86_12725	COG1725	Transcriptional regulator
HYG86_12730	COG1131	(ABC) transporter
HYG86_12750	COG0488	(ABC) transporter
HYG86_12765	COG2966	Psort location CytoplasmicMembrane, score
HYG86_12775	COG0116	Belongs to the methyltransferase superfamily
HYG86_12800	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYG86_12805	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_12805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_12810	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG86_12820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG86_12825	COG0166	Belongs to the GPI family
HYG86_12835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYG86_12845	COG0584	glycerophosphoryl diester phosphodiesterase
HYG86_12850	COG2211	Major facilitator Superfamily
HYG86_12855	COG1523	belongs to the glycosyl hydrolase 13 family
HYG86_12880	COG2813	Specifically methylates the guanine in position
HYG86_12890	COG0564	pseudouridine synthase activity
HYG86_12895	COG1615	UPF0182 protein
HYG86_12935	COG1136	(ABC) transporter
HYG86_12980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG86_12990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG86_13005	COG1278	Cold shock
HYG86_13010	COG1595	DNA-templated transcription, initiation
HYG86_13030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYG86_13045	COG1739	Uncharacterized protein family UPF0029
HYG86_13060	COG0735	belongs to the Fur family
HYG86_13070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HYG86_13075	COG0366	Alpha amylase catalytic
HYG86_13075	COG1874	Beta-galactosidase
HYG86_13080	COG3103	Sh3 type 3 domain protein
HYG86_13080	COG1388	LysM domain
HYG86_13080	COG0791	NLP P60 protein
HYG86_13090	COG4109	DRTGG domain
HYG86_13105	COG0688	phosphatidylethanolamine metabolic process
HYG86_13120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYG86_13125	COG0281	malic enzyme
HYG86_13165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG86_13185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_13195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG86_13200	COG1028	Short-chain dehydrogenase reductase Sdr
HYG86_13205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG86_13215	COG0511	ligase activity, forming carbon-carbon bonds
HYG86_13220	COG0439	Biotin carboxylase
HYG86_13225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG86_13230	COG0825	malonyl-CoA metabolic process
HYG86_13235	COG0733	neurotransmitter:sodium symporter activity
HYG86_13240	COG3679	Belongs to the UPF0342 family
HYG86_13250	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG86_13255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYG86_13255	COG1522	sequence-specific DNA binding
HYG86_13260	COG2313	pseudouridylate synthase activity
HYG86_13265	COG0612	Peptidase, M16
HYG86_13270	COG0612	Peptidase, M16
HYG86_13295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_13300	COG1595	DNA-templated transcription, initiation
HYG86_13310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_13310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG86_13315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYG86_13320	COG1971	Probably functions as a manganese efflux pump
HYG86_13325	COG0237	dephospho-CoA kinase activity
HYG86_13330	COG0741	lytic transglycosylase activity
HYG86_13345	COG0601	transmembrane transport
HYG86_13350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG86_13355	COG0444	Belongs to the ABC transporter superfamily
HYG86_13360	COG4608	Belongs to the ABC transporter superfamily
HYG86_13430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYG86_13435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG86_13440	COG0569	domain protein
HYG86_13445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG86_13450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYG86_13455	COG0072	phenylalanine-tRNA ligase activity
HYG86_13455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG86_13465	COG1286	toxin biosynthetic process
HYG86_13470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG86_13470	COG1796	DNA polymerase
HYG86_13475	COG1193	negative regulation of DNA recombination
HYG86_13480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYG86_13485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYG86_13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG86_13535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYG86_13565	COG1683	Conserved Protein
HYG86_13570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG86_13575	COG0217	transcriptional regulatory protein
HYG86_13585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYG86_13595	COG2255	four-way junction helicase activity
HYG86_13605	COG1191	sigma factor activity
HYG86_13615	COG2247	cell wall binding repeat
HYG86_13615	COG2385	sporulation resulting in formation of a cellular spore
HYG86_13625	COG0343	queuine tRNA-ribosyltransferase activity
HYG86_13630	COG1862	Preprotein translocase
HYG86_13655	COG0488	(ABC) transporter
HYG86_13660	COG0367	asparagine synthase
HYG86_13665	COG2059	Chromate
HYG86_13680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG86_13715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG86_13720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG86_13725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG86_13725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG86_13730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG86_13735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYG86_13740	COG1490	D-aminoacyl-tRNA deacylase activity
HYG86_13745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG86_13775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG86_13780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYG86_13795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG86_13800	COG1757	Na H antiporter
HYG86_13810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYG86_13835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYG86_13845	COG1307	EDD domain protein, DegV family
HYG86_13855	COG3839	Belongs to the ABC transporter superfamily
HYG86_13875	COG3290	protein histidine kinase activity
HYG86_13875	COG3829	transcription factor binding
HYG86_13895	COG0183	Belongs to the thiolase family
HYG86_13900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYG86_13910	COG2031	fatty acid transporter
HYG86_13930	COG0778	Nitroreductase
HYG86_13945	COG0488	(ABC) transporter
HYG86_13960	COG2873	o-acetylhomoserine
HYG86_13990	COG1840	ABC-type Fe3 transport system, periplasmic component
HYG86_14000	COG3842	ATPase activity
HYG86_14010	COG3711	transcriptional antiterminator
HYG86_14030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYG86_14045	COG2199	diguanylate cyclase activity
HYG86_14060	COG1396	sequence-specific DNA binding
HYG86_14065	COG0561	phosphatase activity
HYG86_14080	COG3829	transcription factor binding
HYG86_14080	COG3290	protein histidine kinase activity
HYG86_14090	COG1151	hydroxylamine reductase activity
HYG86_14105	COG0024	Methionine aminopeptidase
HYG86_14115	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HYG86_14125	COG1070	Carbohydrate kinase
HYG86_14130	COG1316	TRANSCRIPTIONal
HYG86_14140	COG1263	PTS System
HYG86_14140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG86_14145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_14160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG86_14175	COG1131	(ABC) transporter
HYG86_14180	COG1725	Transcriptional regulator
HYG86_14185	COG0628	permease
HYG86_14190	COG1253	flavin adenine dinucleotide binding
HYG86_14195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG86_14200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG86_14210	COG3037	sugar-specific permease SgaT UlaA
HYG86_14215	COG3959	Transketolase, thiamine diphosphate binding domain
HYG86_14220	COG3958	Transketolase
HYG86_14230	COG2378	regulation of single-species biofilm formation
HYG86_14250	COG1131	(ABC) transporter
HYG86_14265	COG4585	Histidine kinase
HYG86_14270	COG2197	response regulator
HYG86_14290	COG1233	COG1233 Phytoene dehydrogenase and related
HYG86_14380	COG1131	(ABC) transporter
HYG86_14400	COG0251	oxidation-reduction process
HYG86_14415	COG2364	Membrane
HYG86_14425	COG2361	Protein of unknown function DUF86
HYG86_14475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG86_14480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG86_14485	COG1120	ATPase activity
HYG86_14490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG86_14505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYG86_14510	COG0066	3-isopropylmalate dehydratase activity
HYG86_14555	COG0840	transmembrane signaling receptor activity
HYG86_14565	COG3328	transposase activity
HYG86_14570	COG2364	Membrane
HYG86_14625	COG0513	Belongs to the DEAD box helicase family
HYG86_14695	COG2105	PFAM AIG2 family protein
HYG86_14745	COG0484	heat shock protein binding
HYG86_14750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_14750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HYG86_14775	COG2105	PFAM AIG2 family protein
HYG86_14790	COG1131	(ABC) transporter
HYG86_14795	COG4585	Histidine kinase
HYG86_14800	COG2197	response regulator
HYG86_14825	COG1114	Component of the transport system for branched-chain amino acids
HYG86_14835	COG0386	Belongs to the glutathione peroxidase family
HYG86_14850	COG1131	(ABC) transporter
HYG86_14870	COG4585	Histidine kinase
HYG86_14875	COG2197	response regulator
HYG86_14900	COG0840	transmembrane signaling receptor activity
HYG86_14920	COG1151	hydroxylamine reductase activity
HYG86_14945	COG3022	response to hydroperoxide
HYG86_14950	COG0840	transmembrane signaling receptor activity
HYG86_14955	COG0484	heat shock protein binding
HYG86_14975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYG86_14980	COG1131	(ABC) transporter
HYG86_15000	COG1309	transcriptional regulator
HYG86_15010	COG4555	ABC transporter
HYG86_15020	COG4555	ABC transporter
HYG86_15035	COG3314	Sporulation integral membrane protein YlbJ
HYG86_15065	COG0697	spore germination
HYG86_15075	COG1196	nuclear chromosome segregation
HYG86_15075	COG0741	lytic transglycosylase activity
HYG86_15075	COG0739	heme binding
HYG86_15100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYG86_15105	COG0840	transmembrane signaling receptor activity
HYG86_15135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG86_15140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG86_15145	COG0656	L-ascorbic acid biosynthetic process
HYG86_15150	COG0840	transmembrane signaling receptor activity
HYG86_15160	COG2081	HI0933 family
HYG86_15180	COG1074	ATP-dependent DNA helicase activity
HYG86_15205	COG0124	histidyl-tRNA synthetase
HYG86_15220	COG1307	EDD domain protein, DegV family
HYG86_15245	COG0513	Belongs to the DEAD box helicase family
HYG86_15260	COG3409	Peptidoglycan-binding domain 1 protein
HYG86_15260	COG3773	Cell wall hydrolase
HYG86_15275	COG4260	virion core protein, lumpy skin disease virus
HYG86_15290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG86_15315	COG1032	radical SAM domain protein
HYG86_15335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG86_15345	COG0312	modulator of DNA gyrase
HYG86_15350	COG0668	transmembrane transport
HYG86_15355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG86_15360	COG0534	Mate efflux family protein
HYG86_15375	COG1131	(ABC) transporter
HYG86_15395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYG86_15405	COG0778	Nitroreductase
HYG86_15410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_15415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG86_15420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG86_15440	COG4191	Histidine kinase
HYG86_15445	COG2204	response regulator
HYG86_15475	COG0745	RESPONSE REGULATOR receiver
HYG86_15480	COG5002	protein histidine kinase activity
HYG86_15485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG86_15495	COG3328	transposase activity
HYG86_15520	COG0697	spore germination
HYG86_15525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG86_15545	COG0628	permease
HYG86_15550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG86_15555	COG4472	Bacterial protein of unknown function (DUF965)
HYG86_15560	COG0667	Aldo Keto reductase
HYG86_15570	COG3906	Belongs to the UPF0473 family
HYG86_15575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYG86_15580	COG0826	peptidase U32
HYG86_15585	COG0572	uridine kinase
HYG86_15590	COG0768	penicillin binding
HYG86_15600	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYG86_15610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYG86_15620	COG1459	type II secretion system
HYG86_15655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG86_15685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG86_15695	COG1459	type II secretion system
HYG86_15715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYG86_15755	COG1131	(ABC) transporter
HYG86_15770	COG0714	Associated with various cellular activities
HYG86_15810	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_15820	COG3404	Formiminotransferase-cyclodeaminase
HYG86_15835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYG86_15840	COG0509	glycine decarboxylation via glycine cleavage system
HYG86_15845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG86_15850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG86_15855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG86_15860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYG86_15865	COG0006	proline dipeptidase activity
HYG86_15870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYG86_15880	COG3854	ATPases associated with a variety of cellular activities
HYG86_15920	COG1302	Protein conserved in bacteria
HYG86_15940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG86_15950	COG0493	'glutamate synthase
HYG86_15955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYG86_15960	COG1570	exodeoxyribonuclease VII activity
HYG86_15965	COG1722	exodeoxyribonuclease VII activity
HYG86_15975	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYG86_15985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYG86_15990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYG86_16000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYG86_16005	COG0497	DNA recombination
HYG86_16010	COG0750	zinc metalloprotease
HYG86_16015	COG0745	RESPONSE REGULATOR receiver
HYG86_16040	COG3829	transcription factor binding
HYG86_16040	COG3290	protein histidine kinase activity
HYG86_16050	COG3426	butyrate kinase activity
HYG86_16055	COG0280	phosphate acetyltransferase
HYG86_16065	COG3426	butyrate kinase activity
HYG86_16080	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG86_16080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG86_16095	COG1067	ATP-dependent peptidase activity
HYG86_16105	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG86_16115	COG1379	DNA repair
HYG86_16120	COG1300	Membrane
HYG86_16130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYG86_16135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HYG86_16140	COG1592	Rubrerythrin
HYG86_16150	COG4974	Belongs to the 'phage' integrase family
HYG86_16155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG86_16165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYG86_16170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HYG86_16175	COG1686	Belongs to the peptidase S11 family
HYG86_16185	COG2172	sigma factor antagonist activity
HYG86_16205	COG3360	Dodecin
HYG86_16215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG86_16235	COG0697	spore germination
HYG86_16250	COG1924	4 iron, 4 sulfur cluster binding
HYG86_16255	COG0617	tRNA 3'-terminal CCA addition
HYG86_16255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG86_16255	COG3620	sequence-specific DNA binding
HYG86_16260	COG1994	Peptidase M50
HYG86_16265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYG86_16270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYG86_16280	COG3874	Sporulation protein YtfJ
HYG86_16285	COG1686	Belongs to the peptidase S11 family
HYG86_16290	COG2715	membrane protein required for spore maturation
HYG86_16295	COG0700	Nucleoside recognition
HYG86_16305	COG0445	tRNA wobble uridine modification
HYG86_16315	COG1187	pseudouridine synthase activity
HYG86_16320	COG0517	IMP dehydrogenase activity
HYG86_16325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HYG86_16330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG86_16330	COG0574	Belongs to the PEP-utilizing enzyme family
HYG86_16335	COG1686	Belongs to the peptidase S11 family
HYG86_16340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG86_16345	COG1671	Belongs to the UPF0178 family
HYG86_16375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYG86_16395	COG0534	Mate efflux family protein
HYG86_16415	COG4224	UPF0291 protein
HYG86_16420	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG86_16430	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYG86_16455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG86_16460	COG0495	leucyl-tRNA aminoacylation
HYG86_16470	COG1217	gtp-binding protein TYPA
HYG86_16480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYG86_16500	COG2385	sporulation resulting in formation of a cellular spore
HYG86_16520	COG1141	Ferredoxin
HYG86_16530	COG0142	geranyltranstransferase activity
HYG86_16545	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HYG86_16550	COG0540	Belongs to the ATCase OTCase family
HYG86_16560	COG0540	Belongs to the ATCase OTCase family
HYG86_16565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG86_16570	COG0284	orotidine-5'-phosphate decarboxylase activity
HYG86_16575	COG0505	Belongs to the CarA family
HYG86_16580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYG86_16585	COG0543	2 iron, 2 sulfur cluster binding
HYG86_16590	COG0167	dihydroorotate dehydrogenase activity
HYG86_16600	COG1854	S-ribosylhomocysteine lyase activity
HYG86_16625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_16630	COG2244	polysaccharide biosynthetic process
HYG86_16645	COG0492	ferredoxin-NADP+ reductase activity
HYG86_16650	COG1363	Peptidase, m42
HYG86_16660	COG2323	membrane
HYG86_16675	COG1765	OsmC-like protein
HYG86_16680	COG1959	2 iron, 2 sulfur cluster binding
HYG86_16690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG86_16695	COG1937	Protein conserved in bacteria
HYG86_16705	COG0785	Cytochrome C biogenesis protein
HYG86_16710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYG86_16725	COG2001	Belongs to the MraZ family
HYG86_16730	COG0275	rRNA processing
HYG86_16740	COG0768	penicillin binding
HYG86_16745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG86_16750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG86_16755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG86_16765	COG0772	Belongs to the SEDS family
HYG86_16770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG86_16775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG86_16785	COG3879	Bacterial protein of unknown function (DUF881)
HYG86_16790	COG3856	small basic protein
HYG86_16795	COG0849	cell division
HYG86_16800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYG86_16810	COG1191	sigma factor activity
HYG86_16840	COG1191	sigma factor activity
HYG86_16850	COG1873	PFAM PRC-barrel domain
HYG86_16855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG86_16865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYG86_16875	COG2302	S4 RNA-binding domain
HYG86_16880	COG3599	regulation of cell shape
HYG86_16895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYG86_16900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYG86_16905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYG86_16915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYG86_16920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYG86_16925	COG0564	pseudouridine synthase activity
HYG86_16930	COG2233	PERMEase
HYG86_16940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYG86_16945	COG1561	YicC-like family, N-terminal region
HYG86_16950	COG2052	Domain of unknown function (DUF370)
HYG86_16955	COG0194	GDP metabolic process
HYG86_16960	COG1758	RNA polymerase activity
HYG86_16965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG86_16970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYG86_16975	COG0242	peptide deformylase activity
HYG86_16980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG86_16990	COG2738	Putative neutral zinc metallopeptidase
HYG86_16995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG86_16995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG86_17005	COG0631	protein serine/threonine phosphatase activity
HYG86_17010	COG0515	serine threonine protein kinase
HYG86_17010	COG2815	serine threonine protein kinase
HYG86_17015	COG1162	GTPase activity
HYG86_17020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYG86_17030	COG3859	Proton-coupled thiamine transporter YuaJ
HYG86_17040	COG0622	Phosphoesterase
HYG86_17050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYG86_17055	COG1302	Protein conserved in bacteria
HYG86_17060	COG1461	Dihydroxyacetone kinase
HYG86_17070	COG1760	l-serine dehydratase
HYG86_17075	COG1760	l-serine dehydratase
HYG86_17080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYG86_17095	COG0742	ribosomal rna small subunit methyltransferase
HYG86_17100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYG86_17105	COG3314	Sporulation integral membrane protein YlbJ
HYG86_17110	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYG86_17115	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYG86_17120	COG1323	Belongs to the UPF0348 family
HYG86_17125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYG86_17135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYG86_17145	COG0416	fatty acid biosynthetic process
HYG86_17150	COG1307	EDD domain protein, DegV family
HYG86_17155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG86_17165	COG1196	nuclear chromosome segregation
HYG86_17170	COG0552	protein localization to endoplasmic reticulum
HYG86_17175	COG1595	DNA-templated transcription, initiation
HYG86_17180	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HYG86_17185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYG86_17205	COG0336	Belongs to the RNA methyltransferase TrmD family
HYG86_17210	COG0335	large ribosomal subunit rRNA binding
HYG86_17220	COG0681	Belongs to the peptidase S26 family
HYG86_17225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYG86_17240	COG0792	nuclease activity
HYG86_17255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG86_17260	COG0606	chelatase, subunit chli
HYG86_17265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYG86_17275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG86_17280	COG1363	Peptidase, m42
HYG86_17285	COG1363	Peptidase, m42
HYG86_17300	COG1803	Methylglyoxal synthase
HYG86_17305	COG0018	arginyl-trna synthetase
HYG86_17310	COG1509	lysine 2,3-aminomutase activity
HYG86_17315	COG0758	DNA mediated transformation
HYG86_17320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG86_17325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HYG86_17330	COG4974	Belongs to the 'phage' integrase family
HYG86_17340	COG1815	bacterial-type flagellum-dependent cell motility
HYG86_17345	COG1558	bacterial-type flagellum-dependent cell motility
HYG86_17350	COG1677	Flagellar hook-basal body complex protein FliE
HYG86_17360	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_17370	COG1157	protein secretion by the type III secretion system
HYG86_17390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYG86_17400	COG4786	Flagellar basal body rod
HYG86_17405	COG1582	Flagellar protein (FlbD)
HYG86_17415	COG1360	Flagellar Motor Protein
HYG86_17425	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_17430	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG86_17430	COG1776	CheC inhibitor of MCP methylation
HYG86_17435	COG2201	protein-glutamate methylesterase activity
HYG86_17440	COG3190	flagellar
HYG86_17445	COG1338	Plays a role in the flagellum-specific transport system
HYG86_17450	COG1987	bacterial-type flagellum assembly
HYG86_17455	COG1684	flagellar biosynthetic protein fliR
HYG86_17460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG86_17465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG86_17470	COG1419	protein localization to endoplasmic reticulum
HYG86_17475	COG0455	bacterial-type flagellum organization
HYG86_17485	COG0643	Histidine kinase
HYG86_17485	COG2198	Histidine kinase
HYG86_17490	COG0835	chemotaxis
HYG86_17495	COG1776	CheC inhibitor of MCP methylation
HYG86_17500	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYG86_17505	COG1191	sigma factor activity
HYG86_17535	COG0052	Belongs to the universal ribosomal protein uS2 family
HYG86_17540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG86_17545	COG0528	UMP kinase activity
HYG86_17550	COG0233	cytoplasmic translational termination
HYG86_17565	COG0575	Belongs to the CDS family
HYG86_17575	COG0750	zinc metalloprotease
HYG86_17580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYG86_17585	COG0442	prolyl-tRNA aminoacylation
HYG86_17590	COG0463	Glycosyl transferase, family 2
HYG86_17595	COG1285	pathogenesis
HYG86_17605	COG0779	Required for maturation of 30S ribosomal subunits
HYG86_17610	COG0195	Participates in both transcription termination and antitermination
HYG86_17615	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYG86_17620	COG1358	cellular component organization or biogenesis
HYG86_17625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYG86_17630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYG86_17640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYG86_17645	COG0196	riboflavin kinase activity
HYG86_17650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYG86_17655	COG1185	polyribonucleotide nucleotidyltransferase activity
HYG86_17660	COG0726	polysaccharide deacetylase
HYG86_17670	COG1873	PFAM PRC-barrel domain
HYG86_17680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG86_17685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG86_17690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG86_17695	COG0527	aspartate kinase activity
HYG86_17700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG86_17710	COG0537	adenosine 5'-monophosphoramidase activity
HYG86_17720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYG86_17725	COG0740	serine-type endopeptidase activity
HYG86_17735	COG1968	undecaprenyl-diphosphatase activity
HYG86_17740	COG1674	ftsk spoiiie
HYG86_17745	COG2188	Transcriptional regulator
HYG86_17750	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG86_17755	COG3845	ABC transporter
HYG86_17760	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG86_17765	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG86_17770	COG0789	Transcriptional regulator
HYG86_17775	COG0174	glutamine synthetase
HYG86_17790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_17795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG86_17805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG86_17810	COG1058	Belongs to the CinA family
HYG86_17810	COG1546	Belongs to the CinA family
HYG86_17820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYG86_17835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG86_17850	COG1418	mRNA catabolic process
HYG86_17855	COG1692	metallophosphoesterase
HYG86_17860	COG2359	stage V sporulation protein S
HYG86_17870	COG0613	PHP domain protein
HYG86_17885	COG4869	propanediol catabolic process
HYG86_17900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG86_17905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG86_17915	COG2136	Putative SAM-dependent methyltransferase
HYG86_17915	COG2521	methyltransferase
HYG86_17920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYG86_17925	COG1923	regulation of RNA biosynthetic process
HYG86_17930	COG0464	growth
HYG86_17935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG86_17950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYG86_17960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG86_17970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG86_18030	COG1053	succinate dehydrogenase
HYG86_18035	COG2257	FlhB HrpN YscU SpaS Family
HYG86_18050	COG0840	transmembrane signaling receptor activity
HYG86_18065	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYG86_18075	COG0728	peptidoglycan biosynthetic process
HYG86_18080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYG86_18085	COG0708	Exodeoxyribonuclease III
HYG86_18095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYG86_18100	COG0489	protein tyrosine kinase activity
HYG86_18110	COG0326	Molecular chaperone. Has ATPase activity
HYG86_18115	COG0322	excinuclease ABC activity
HYG86_18135	COG2385	sporulation resulting in formation of a cellular spore