locus-tag	class	description
M9189_00010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M9189_00025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M9189_00045	COG2957	Belongs to the agmatine deiminase family
M9189_00050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9189_00055	COG0561	phosphatase activity
M9189_00075	COG1472	Belongs to the glycosyl hydrolase 3 family
M9189_00080	COG2382	esterase
M9189_00085	COG3693	PFAM glycoside hydrolase, family 10
M9189_00085	COG2382	esterase
M9189_00095	COG0612	Peptidase, M16
M9189_00100	COG0612	Peptidase, M16
M9189_00105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M9189_00120	COG1428	Deoxynucleoside kinase
M9189_00145	COG0594	ribonuclease P activity
M9189_00150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M9189_00155	COG2373	Large extracellular alpha-helical protein
M9189_00165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M9189_00170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9189_00185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9189_00190	COG1215	transferase activity, transferring glycosyl groups
M9189_00205	COG1216	Glycosyl transferase, family 2
M9189_00215	COG0673	inositol 2-dehydrogenase activity
M9189_00220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M9189_00255	COG2177	Part of the ABC transporter FtsEX involved in
M9189_00265	COG1968	undecaprenyl-diphosphatase activity
M9189_00270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M9189_00275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M9189_00285	COG0205	6-phosphofructokinase activity
M9189_00290	COG0175	sulfate reduction
M9189_00300	COG0793	Belongs to the peptidase S41A family
M9189_00305	COG2131	deaminase
M9189_00315	COG1472	Belongs to the glycosyl hydrolase 3 family
M9189_00320	COG4953	penicillin-binding protein 1C
M9189_00325	COG0793	Belongs to the peptidase S41A family
M9189_00330	COG2839	Protein conserved in bacteria
M9189_00335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9189_00335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9189_00340	COG4822	anaerobic cobalamin biosynthetic process
M9189_00350	COG0142	geranyltranstransferase activity
M9189_00360	COG1490	D-aminoacyl-tRNA deacylase activity
M9189_00370	COG0322	excinuclease ABC activity
M9189_00375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M9189_00380	COG0445	tRNA wobble uridine modification
M9189_00385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M9189_00410	COG0756	dUTP diphosphatase activity
M9189_00420	COG2255	four-way junction helicase activity
M9189_00425	COG0784	Response regulator, receiver
M9189_00425	COG2205	protein histidine kinase activity
M9189_00425	COG5002	protein histidine kinase activity
M9189_00430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M9189_00435	COG0698	ribose 5-phosphate isomerase
M9189_00440	COG1959	2 iron, 2 sulfur cluster binding
M9189_00450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9189_00465	COG0842	Transport permease protein
M9189_00465	COG1131	(ABC) transporter
M9189_00465	COG1716	ATPase activity
M9189_00500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M9189_00505	COG2199	diguanylate cyclase activity
M9189_00505	COG2202	Pas domain
M9189_00505	COG2200	EAL domain
M9189_00510	COG2201	protein-glutamate methylesterase activity
M9189_00515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M9189_00525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M9189_00535	COG0835	chemotaxis
M9189_00540	COG2198	Histidine kinase
M9189_00540	COG0643	Histidine kinase
M9189_00550	COG0745	RESPONSE REGULATOR receiver
M9189_00560	COG0840	transmembrane signaling receptor activity
M9189_00575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M9189_00585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M9189_00595	COG0859	PFAM glycosyl transferase family 9
M9189_00600	COG0297	glycogen (starch) synthase activity
M9189_00625	COG0463	Glycosyl transferase, family 2
M9189_00630	COG1368	sulfuric ester hydrolase activity
M9189_00635	COG0826	peptidase U32
M9189_00655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M9189_00660	COG0589	response to stress
M9189_00680	COG3385	transposase activity
M9189_00695	COG0356	it plays a direct role in the translocation of protons across the membrane
M9189_00700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9189_00705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M9189_00710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9189_00715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M9189_00720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M9189_00730	COG0659	secondary active sulfate transmembrane transporter activity
M9189_00760	COG1011	Hydrolase
M9189_00785	COG5002	protein histidine kinase activity
M9189_00790	COG0745	RESPONSE REGULATOR receiver
M9189_00825	COG3118	belongs to the thioredoxin family
M9189_00830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M9189_00845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M9189_00850	COG2239	Acts as a magnesium transporter
M9189_00870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9189_00885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M9189_00900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9189_00905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M9189_00925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9189_00930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9189_00955	COG0066	3-isopropylmalate dehydratase activity
M9189_00960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M9189_00965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M9189_00970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M9189_00980	COG0028	Belongs to the TPP enzyme family
M9189_00985	COG0129	dihydroxy-acid dehydratase activity
M9189_00990	COG2171	N-acyltransferase activity
M9189_01000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M9189_01005	COG0228	four-way junction DNA binding
M9189_01010	COG0700	Nucleoside recognition
M9189_01020	COG0358	DNA primase activity
M9189_01020	COG0305	Participates in initiation and elongation during chromosome replication
M9189_01025	COG2211	Major facilitator Superfamily
M9189_01040	COG1215	transferase activity, transferring glycosyl groups
M9189_01050	COG0166	Belongs to the GPI family
M9189_01055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M9189_01060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M9189_01065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M9189_01070	COG0321	lipoyl(octanoyl) transferase activity
M9189_01075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M9189_01075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M9189_01080	COG0697	spore germination
M9189_01095	COG2832	Protein of unknown function (DUF454)
M9189_01100	COG2223	nitrite transmembrane transporter activity
M9189_01110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M9189_01130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M9189_01140	COG0606	chelatase, subunit chli
M9189_01150	COG1131	(ABC) transporter
M9189_01150	COG0842	Transport permease protein
M9189_01150	COG1716	ATPase activity
M9189_01160	COG1028	Short-chain dehydrogenase reductase Sdr
M9189_01170	COG1410	methionine synthase
M9189_01170	COG0646	methionine synthase
M9189_01175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M9189_01180	COG2137	regulation of response to DNA damage stimulus
M9189_01195	COG1509	lysine 2,3-aminomutase activity
M9189_01200	COG0772	Belongs to the SEDS family
M9189_01220	COG1077	Cell shape determining protein MreB Mrl
M9189_01225	COG0138	bifunctional purine biosynthesis protein purh
M9189_01230	COG1040	competence protein
M9189_01235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9189_01235	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9189_01245	COG0427	acetyl-CoA hydrolase
M9189_01250	COG0259	pyridoxamine-phosphate oxidase activity
M9189_01255	COG1131	(ABC) transporter
M9189_01260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M9189_01270	COG1192	Involved in chromosome partitioning
M9189_01275	COG1475	DNA binding
M9189_01285	COG0791	NLP P60 protein
M9189_01285	COG1388	LysM domain
M9189_01320	COG0714	Associated with various cellular activities
M9189_01330	COG1752	Esterase of the alpha-beta hydrolase superfamily
M9189_01335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M9189_01340	COG1022	Amp-dependent synthetase and ligase
M9189_01360	COG2204	response regulator
M9189_01370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M9189_01375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9189_01395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M9189_01400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M9189_01405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M9189_01415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M9189_01425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9189_01445	COG0196	riboflavin kinase activity
M9189_01475	COG0254	rRNA binding
M9189_01480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M9189_01500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M9189_01515	COG2160	L-arabinose isomerase activity
M9189_01535	COG1137	ATPase activity
M9189_01540	COG0805	protein transport
M9189_01545	COG3250	beta-galactosidase activity
M9189_01550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M9189_01555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M9189_01555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M9189_01560	COG0423	glycine-tRNA ligase activity
M9189_01565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M9189_01570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M9189_01575	COG0784	Response regulator, receiver
M9189_01575	COG2205	protein histidine kinase activity
M9189_01575	COG5002	protein histidine kinase activity
M9189_01580	COG1162	GTPase activity
M9189_01595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M9189_01600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9189_01610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M9189_01615	COG2116	formate transmembrane transporter activity
M9189_01640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M9189_01655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M9189_01680	COG0740	serine-type endopeptidase activity
M9189_01685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M9189_01690	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M9189_01695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9189_01700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9189_01700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9189_01705	COG2890	protein-(glutamine-N5) methyltransferase activity
M9189_01710	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M9189_01715	COG0205	6-phosphofructokinase activity
M9189_01720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M9189_01725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M9189_01735	COG2706	6-phosphogluconolactonase activity
M9189_01740	COG0514	ATP-dependent DNA helicase (RecQ)
M9189_01760	COG0563	adenylate kinase activity
M9189_01765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9189_01775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M9189_01780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M9189_01780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M9189_01790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M9189_01800	COG0799	negative regulation of ribosome biogenesis
M9189_01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M9189_01810	COG4589	Belongs to the CDS family
M9189_01815	COG0688	phosphatidylethanolamine metabolic process
M9189_01820	COG3292	Two component regulator propeller
M9189_01820	COG2205	protein histidine kinase activity
M9189_01820	COG3292	Two component regulator propeller
M9189_01820	COG0745	RESPONSE REGULATOR receiver
M9189_01820	COG0745	RESPONSE REGULATOR receiver
M9189_01820	COG2205	protein histidine kinase activity
M9189_01845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_01850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M9189_01860	COG0131	Imidazoleglycerol-phosphate dehydratase
M9189_01865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M9189_01870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M9189_01875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M9189_01895	COG1183	phosphatidylcholine synthase activity
M9189_01900	COG2205	protein histidine kinase activity
M9189_01900	COG3437	response regulator, receiver
M9189_01900	COG4999	Histidine kinase
M9189_01900	COG3850	Histidine kinase
M9189_01905	COG1472	Belongs to the glycosyl hydrolase 3 family
M9189_01920	COG1294	oxidase, subunit
M9189_01925	COG1271	oxidase subunit
M9189_01935	COG3292	Two component regulator propeller
M9189_01935	COG0745	RESPONSE REGULATOR receiver
M9189_01935	COG2205	protein histidine kinase activity
M9189_01945	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_01965	COG4771	TonB-dependent receptor
M9189_01990	COG1438	arginine binding
M9189_02000	COG0137	argininosuccinate synthase activity
M9189_02005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M9189_02020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M9189_02025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M9189_02030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M9189_02035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M9189_02040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M9189_02050	COG0165	Argininosuccinate lyase
M9189_02080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9189_02085	COG2204	response regulator
M9189_02100	COG4152	abc transporter atp-binding protein
M9189_02110	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M9189_02115	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M9189_02130	COG4535	Mg2 and Co2 transporter CorC
M9189_02135	COG0629	single-stranded DNA binding
M9189_02165	COG5002	protein histidine kinase activity
M9189_02175	COG0776	regulation of translation
M9189_02185	COG1530	ribonuclease E activity
M9189_02200	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_02230	COG0436	Aminotransferase
M9189_02240	COG0525	valine-tRNA ligase activity
M9189_02250	COG2885	chlorophyll binding
M9189_02270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M9189_02275	COG0193	aminoacyl-tRNA hydrolase activity
M9189_02280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M9189_02285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M9189_02290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M9189_02295	COG1482	cell wall glycoprotein biosynthetic process
M9189_02300	COG0527	aspartate kinase activity
M9189_02305	COG0019	diaminopimelate decarboxylase activity
M9189_02320	COG0210	DNA helicase
M9189_02330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M9189_02335	COG3385	transposase activity
M9189_02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_02350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M9189_02355	COG0484	heat shock protein binding
M9189_02360	COG0583	DNA-binding transcription factor activity
M9189_02370	COG2885	chlorophyll binding
M9189_02395	COG2211	Major facilitator Superfamily
M9189_02400	COG0140	phosphoribosyl-ATP diphosphatase activity
M9189_02400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M9189_02405	COG0107	imidazoleglycerol-phosphate synthase activity
M9189_02410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M9189_02415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M9189_02420	COG0788	formyltetrahydrofolate deformylase activity
M9189_02425	COG0596	Alpha beta hydrolase
M9189_02445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M9189_02455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M9189_02460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9189_02480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M9189_02485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M9189_02490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M9189_02490	COG0674	pyruvate-flavodoxin oxidoreductase activity
M9189_02495	COG1013	pyruvate-flavodoxin oxidoreductase activity
M9189_02505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M9189_02515	COG4591	ABC-type transport system involved in lipoprotein release permease component
M9189_02520	COG3250	beta-galactosidase activity
M9189_02525	COG1993	acr, cog1993
M9189_02530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9189_02535	COG0159	tryptophan synthase activity
M9189_02540	COG0133	tryptophan synthase activity
M9189_02545	COG0135	phosphoribosylanthranilate isomerase activity
M9189_02550	COG0134	indole-3-glycerol-phosphate synthase activity
M9189_02555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9189_02560	COG0512	Glutamine amidotransferase of anthranilate synthase
M9189_02560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9189_02565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9189_02580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M9189_02595	COG2197	response regulator
M9189_02605	COG1160	GTP binding
M9189_02610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M9189_02640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9189_02645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M9189_02650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M9189_02655	COG0049	tRNA binding
M9189_02660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9189_02665	COG0051	transcription antitermination factor activity, RNA binding
M9189_02670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M9189_02675	COG0088	Forms part of the polypeptide exit tunnel
M9189_02680	COG0089	rRNA binding
M9189_02685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M9189_02690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M9189_02695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M9189_02700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M9189_02705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M9189_02710	COG0255	Belongs to the universal ribosomal protein uL29 family
M9189_02715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M9189_02720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M9189_02725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M9189_02730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M9189_02735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M9189_02740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M9189_02745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M9189_02750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M9189_02755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M9189_02760	COG1841	ribosomal large subunit assembly
M9189_02765	COG0200	Binds to the 23S rRNA
M9189_02775	COG0024	Methionine aminopeptidase
M9189_02780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M9189_02785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M9189_02790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M9189_02795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M9189_02800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M9189_02805	COG0202	RNA polymerase activity
M9189_02815	COG0148	phosphopyruvate hydratase activity
M9189_02825	COG3292	Two component regulator propeller
M9189_02825	COG2205	protein histidine kinase activity
M9189_02825	COG0745	RESPONSE REGULATOR receiver
M9189_02830	COG3437	response regulator, receiver
M9189_02830	COG3850	Histidine kinase
M9189_02830	COG4999	Histidine kinase
M9189_02830	COG2205	protein histidine kinase activity
M9189_02840	COG0488	(ABC) transporter
M9189_02880	COG1595	DNA-templated transcription, initiation
M9189_02885	COG0012	GTP binding
M9189_02925	COG1607	acyl-coa hydrolase
M9189_02930	COG1342	Belongs to the UPF0251 family
M9189_02955	COG1484	DNA-dependent DNA replication
M9189_02990	COG4974	Belongs to the 'phage' integrase family
M9189_02995	COG0517	IMP dehydrogenase activity
M9189_03030	COG1136	(ABC) transporter
M9189_03045	COG4191	Histidine kinase
M9189_03060	COG4221	oxidoreductase activity
M9189_03090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_03100	COG3385	transposase activity
M9189_03305	COG0681	Belongs to the peptidase S26 family
M9189_03315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M9189_03325	COG3940	Belongs to the glycosyl hydrolase 43 family
M9189_03380	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M9189_03385	COG1518	maintenance of DNA repeat elements
M9189_03395	COG0590	tRNA wobble adenosine to inosine editing
M9189_03400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M9189_03425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9189_03440	COG2001	Belongs to the MraZ family
M9189_03445	COG0275	rRNA processing
M9189_03455	COG0768	penicillin binding
M9189_03460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M9189_03465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9189_03470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M9189_03480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M9189_03485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9189_03500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M9189_03505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9189_03510	COG4535	Mg2 and Co2 transporter CorC
M9189_03530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M9189_03535	COG2197	response regulator
M9189_03540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M9189_03545	COG0527	aspartate kinase activity
M9189_03560	COG0463	Glycosyl transferase, family 2
M9189_03585	COG3344	reverse transcriptase
M9189_03605	COG1187	pseudouridine synthase activity
M9189_03610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9189_03620	COG0577	efflux transmembrane transporter activity
M9189_03620	COG1136	(ABC) transporter
M9189_03635	COG0039	L-malate dehydrogenase activity
M9189_03645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M9189_03650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9189_03655	COG1120	ATPase activity
M9189_03660	COG4771	TonB-dependent receptor
M9189_03675	COG2096	Adenosyltransferase
M9189_03680	COG0351	phosphomethylpyrimidine kinase
M9189_03685	COG0351	phosphomethylpyrimidine kinase
M9189_03685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M9189_03685	COG0352	thiamine-phosphate diphosphorylase activity
M9189_03690	COG0352	thiamine-phosphate diphosphorylase activity
M9189_03695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M9189_03700	COG2226	methyltransferase
M9189_03715	COG0628	permease
M9189_03730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M9189_03730	COG0517	IMP dehydrogenase activity
M9189_03730	COG0617	tRNA 3'-terminal CCA addition
M9189_03735	COG3118	belongs to the thioredoxin family
M9189_03745	COG0564	pseudouridine synthase activity
M9189_03750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M9189_03755	COG1193	negative regulation of DNA recombination
M9189_03780	COG0471	metal ion transport
M9189_03780	COG0490	domain, Protein
M9189_03785	COG4864	UPF0365 protein
M9189_03805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M9189_03810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M9189_03825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9189_03825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9189_03835	COG0443	Heat shock 70 kDa protein
M9189_03850	COG2202	Pas domain
M9189_03850	COG2205	protein histidine kinase activity
M9189_03860	COG0295	cytidine deaminase activity
M9189_03870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M9189_03875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9189_03880	COG0045	succinate-CoA ligase (ADP-forming) activity
M9189_03900	COG1505	serine-type exopeptidase activity
M9189_03910	COG1185	polyribonucleotide nucleotidyltransferase activity
M9189_03915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M9189_03930	COG2205	protein histidine kinase activity
M9189_03930	COG3292	Two component regulator propeller
M9189_03930	COG0745	RESPONSE REGULATOR receiver
M9189_03950	COG0612	Peptidase, M16
M9189_03960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9189_03970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M9189_03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9189_03995	COG0463	Glycosyl transferase, family 2
M9189_04020	COG0009	L-threonylcarbamoyladenylate synthase
M9189_04025	COG0569	domain protein
M9189_04030	COG0658	competence protein
M9189_04030	COG2333	competence protein COMEC
M9189_04045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9189_04060	COG2081	HI0933 family
M9189_04080	COG1136	(ABC) transporter
M9189_04080	COG0577	efflux transmembrane transporter activity
M9189_04085	COG2311	Membrane
M9189_04090	COG0840	transmembrane signaling receptor activity
M9189_04115	COG2855	membrane
M9189_04125	COG3275	phosphorelay sensor kinase activity
M9189_04170	COG4584	PFAM Integrase catalytic
M9189_04180	COG1484	DNA-dependent DNA replication
M9189_04185	COG2963	transposase activity
M9189_04205	COG4584	PFAM Integrase catalytic
M9189_04215	COG1484	DNA-dependent DNA replication
M9189_04230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M9189_04235	COG0194	GDP metabolic process
M9189_04240	COG1561	YicC-like family, N-terminal region
M9189_04245	COG0789	Transcriptional regulator
M9189_04250	COG0534	Mate efflux family protein
M9189_04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_04280	COG1131	(ABC) transporter
M9189_04285	COG1131	(ABC) transporter
M9189_04290	COG0842	Transport permease protein
M9189_04300	COG2188	Transcriptional regulator
M9189_04310	COG2115	Belongs to the xylose isomerase family
M9189_04325	COG3572	ergothioneine biosynthetic process
M9189_04330	COG1132	(ABC) transporter
M9189_04335	COG1132	(ABC) transporter
M9189_04345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9189_04355	COG4657	Part of a membrane complex involved in electron transport
M9189_04360	COG4660	Part of a membrane complex involved in electron transport
M9189_04370	COG4658	electron transport chain
M9189_04375	COG4656	Part of a membrane complex involved in electron transport
M9189_04380	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
M9189_04380	COG2878	Part of a membrane complex involved in electron transport
M9189_04390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M9189_04400	COG0514	ATP-dependent DNA helicase (RecQ)
M9189_04415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M9189_04420	COG0513	Belongs to the DEAD box helicase family
M9189_04425	COG2183	response to ionizing radiation
M9189_04435	COG2873	o-acetylhomoserine
M9189_04450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M9189_04455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M9189_04465	COG2373	Large extracellular alpha-helical protein
M9189_04475	COG3387	PFAM Glycoside hydrolase 15-related
M9189_04490	COG2197	response regulator
M9189_04510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M9189_04520	COG0739	heme binding
M9189_04605	COG3385	transposase activity
M9189_04625	COG1459	type II secretion system
M9189_04640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M9189_04640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M9189_04645	COG0009	L-threonylcarbamoyladenylate synthase
M9189_04650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M9189_04660	COG1288	antiporter activity
M9189_04670	COG3104	oligopeptide transport
M9189_04675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M9189_04675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M9189_04700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M9189_04710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9189_04720	COG1408	metallophosphoesterase
M9189_04725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M9189_04750	COG0129	dihydroxy-acid dehydratase activity
M9189_04790	COG3385	transposase activity
M9189_04860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M9189_04865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M9189_04870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M9189_04880	COG1028	Short-chain dehydrogenase reductase Sdr
M9189_04890	COG1979	alcohol dehydrogenase
M9189_04900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9189_04920	COG0280	phosphate acetyltransferase
M9189_04925	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9189_04930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M9189_04935	COG0673	inositol 2-dehydrogenase activity
M9189_04940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M9189_04945	COG0181	hydroxymethylbilane synthase activity
M9189_04955	COG0113	porphobilinogen synthase activity
M9189_04960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M9189_04965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M9189_04990	COG2195	Cleaves the N-terminal amino acid of tripeptides
M9189_05000	COG0492	ferredoxin-NADP+ reductase activity
M9189_05020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M9189_05030	COG0656	L-ascorbic acid biosynthetic process
M9189_05040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M9189_05045	COG0798	PFAM Bile acid sodium symporter
M9189_05085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M9189_05090	COG0488	(ABC) transporter
M9189_05110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M9189_05135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M9189_05140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9189_05145	COG0004	ammonium transporteR
M9189_05150	COG0347	Belongs to the P(II) protein family
M9189_05175	COG1304	FMN binding
M9189_05180	COG1960	acyl-CoA dehydrogenase activity
M9189_05195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9189_05210	COG2205	protein histidine kinase activity
M9189_05210	COG3292	Two component regulator propeller
M9189_05210	COG0745	RESPONSE REGULATOR receiver
M9189_05215	COG4771	TonB-dependent receptor
M9189_05220	COG0702	epimerase
M9189_05225	COG3661	Belongs to the glycosyl hydrolase 67 family
M9189_05235	COG0543	2 iron, 2 sulfur cluster binding
M9189_05240	COG0493	'glutamate synthase
M9189_05245	COG0167	dihydroorotate dehydrogenase activity
M9189_05255	COG0360	Binds together with S18 to 16S ribosomal RNA
M9189_05260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M9189_05265	COG0359	binds to the 23S rRNA
M9189_05270	COG0251	oxidation-reduction process
M9189_05285	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9189_05295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9189_05300	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9189_05300	COG1388	LysM domain
M9189_05305	COG0488	(ABC) transporter
M9189_05310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9189_05330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M9189_05340	COG0386	Belongs to the glutathione peroxidase family
M9189_05345	COG0475	glutathione-regulated potassium exporter activity
M9189_05370	COG4584	PFAM Integrase catalytic
M9189_05380	COG1484	DNA-dependent DNA replication
M9189_05440	COG0463	Glycosyl transferase, family 2
M9189_05445	COG1215	transferase activity, transferring glycosyl groups
M9189_05450	COG0438	transferase activity, transferring glycosyl groups
M9189_05550	COG4771	TonB-dependent receptor
M9189_05555	COG2133	pyrroloquinoline quinone binding
M9189_05570	COG0335	large ribosomal subunit rRNA binding
M9189_05580	COG1940	carbohydrate kinase activity
M9189_05585	COG0133	tryptophan synthase activity
M9189_05595	COG3263	regulation of cellular component size
M9189_05615	COG0318	PFAM AMP-dependent synthetase and ligase
M9189_05640	COG2205	protein histidine kinase activity
M9189_05640	COG0784	Response regulator, receiver
M9189_05645	COG0018	arginyl-trna synthetase
M9189_05660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M9189_05670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M9189_05675	COG1480	7TM receptor with intracellular HD hydrolase
M9189_05680	COG0791	NLP P60 protein
M9189_05685	COG0494	nUDIX hydrolase
M9189_05710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M9189_05710	COG0517	IMP dehydrogenase activity
M9189_05715	COG0432	Pfam Uncharacterised protein family UPF0047
M9189_05730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M9189_05745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M9189_05765	COG2884	Cell division ATP-binding protein ftsE
M9189_05770	COG0436	Aminotransferase
M9189_05775	COG0346	lactoylglutathione lyase activity
M9189_05780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9189_05790	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M9189_05795	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M9189_05815	COG1674	ftsk spoiiie
M9189_05830	COG2502	aspartate--ammonia ligase
M9189_05845	COG3279	Response regulator of the LytR AlgR family
M9189_05860	COG1082	Xylose isomerase domain protein TIM barrel
M9189_05870	COG1028	Short-chain dehydrogenase reductase Sdr
M9189_05875	COG3385	transposase activity
M9189_05890	COG1047	Peptidyl-prolyl cis-trans
M9189_05900	COG3344	reverse transcriptase
M9189_05905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M9189_05935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_05955	COG2234	aminopeptidase activity
M9189_05980	COG3385	transposase activity
M9189_06000	COG3657	addiction module killer protein
M9189_06005	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M9189_06010	COG0517	IMP dehydrogenase activity
M9189_06015	COG4974	Belongs to the 'phage' integrase family
M9189_06065	COG0484	heat shock protein binding
M9189_06090	COG4974	Belongs to the 'phage' integrase family
M9189_06105	COG3738	Protein conserved in bacteria
M9189_06155	COG3385	transposase activity
M9189_06215	COG4152	abc transporter atp-binding protein
M9189_06260	COG4152	abc transporter atp-binding protein
M9189_06305	COG2234	aminopeptidase activity
M9189_06310	COG0517	IMP dehydrogenase activity
M9189_06315	COG4974	Belongs to the 'phage' integrase family
M9189_06435	COG2731	YhcH YjgK YiaL family protein
M9189_06440	COG0339	signal peptide processing
M9189_06455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M9189_06465	COG0187	DNA topoisomerase II activity
M9189_06480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9189_06485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M9189_06490	COG0556	nucleotide-excision repair
M9189_06500	COG0318	PFAM AMP-dependent synthetase and ligase
M9189_06510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M9189_06515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M9189_06515	COG0047	phosphoribosylformylglycinamidine synthase activity
M9189_06525	COG0602	queuosine metabolic process
M9189_06530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M9189_06540	COG2264	protein methyltransferase activity
M9189_06545	COG0149	triose-phosphate isomerase activity
M9189_06560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M9189_06575	COG1560	Kdo2-lipid A biosynthetic process
M9189_06580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M9189_06600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M9189_06605	COG4974	Belongs to the 'phage' integrase family
M9189_06625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M9189_06630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9189_06635	COG1091	dTDP-4-dehydrorhamnose reductase activity
M9189_06655	COG0539	negative regulation of cytoplasmic translation
M9189_06665	COG1234	tRNA 3'-trailer cleavage
M9189_06670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M9189_06670	COG0519	Catalyzes the synthesis of GMP from XMP
M9189_06675	COG3409	Peptidoglycan-binding domain 1 protein
M9189_06675	COG0793	Belongs to the peptidase S41A family
M9189_06690	COG1045	serine acetyltransferase
M9189_06705	COG1716	ATPase activity
M9189_06705	COG0842	Transport permease protein
M9189_06705	COG1131	(ABC) transporter
M9189_06715	COG0542	response to heat
M9189_06730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M9189_06735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M9189_06750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M9189_06755	COG0167	dihydroorotate dehydrogenase activity
M9189_06770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M9189_06775	COG1595	DNA-templated transcription, initiation
M9189_06785	COG0463	Glycosyl transferase, family 2
M9189_06785	COG1216	Glycosyl transferase, family 2
M9189_06800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M9189_06805	COG0189	ligase activity
M9189_06810	COG1242	4 iron, 4 sulfur cluster binding
M9189_06830	COG1418	mRNA catabolic process
M9189_06835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9189_06840	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M9189_06845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9189_06850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M9189_06860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M9189_06865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M9189_06870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M9189_06880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9189_06885	COG0101	tRNA pseudouridine synthase activity
M9189_06890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M9189_06905	COG0793	Belongs to the peptidase S41A family
M9189_06905	COG4946	Tricorn protease homolog
M9189_06920	COG3956	TIGRFAM MazG family protein
M9189_06925	COG1702	phosphate starvation-inducible protein PhoH
M9189_06930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M9189_06935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M9189_06950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M9189_06955	COG0321	lipoyl(octanoyl) transferase activity
M9189_06955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M9189_06960	COG1335	isochorismatase
M9189_06965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M9189_06975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M9189_06985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M9189_06990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M9189_07000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M9189_07005	COG2249	NAD(P)H dehydrogenase (quinone) activity
M9189_07010	COG1739	Uncharacterized protein family UPF0029
M9189_07030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M9189_07050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9189_07110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M9189_07120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9189_07135	COG0653	protein targeting
M9189_07140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M9189_07150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M9189_07155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M9189_07165	COG0552	protein localization to endoplasmic reticulum
M9189_07170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M9189_07175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M9189_07185	COG0538	isocitrate dehydrogenase activity
M9189_07195	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9189_07200	COG0022	dehydrogenase e1 component
M9189_07205	COG0716	FMN binding
M9189_07215	COG0543	2 iron, 2 sulfur cluster binding
M9189_07220	COG0167	dihydroorotate dehydrogenase activity
M9189_07235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_07255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M9189_07275	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
M9189_07280	COG1074	ATP-dependent DNA helicase activity
M9189_07290	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M9189_07295	COG0540	Belongs to the ATCase OTCase family
M9189_07300	COG1362	aminopeptidase activity
M9189_07305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M9189_07310	COG0784	Response regulator, receiver
M9189_07315	COG2885	chlorophyll binding
M9189_07390	COG0105	UTP biosynthetic process
M9189_07400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M9189_07410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M9189_07445	COG0116	Belongs to the methyltransferase superfamily
M9189_07445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M9189_07450	COG1528	Iron-storage protein
M9189_07455	COG0439	Biotin carboxylase
M9189_07460	COG0511	ligase activity, forming carbon-carbon bonds
M9189_07460	COG5016	pyruvate
M9189_07465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M9189_07475	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M9189_07480	COG1902	pentaerythritol trinitrate reductase activity
M9189_07485	COG0702	epimerase
M9189_07490	COG1295	ribonuclease BN
M9189_07525	COG0534	Mate efflux family protein
M9189_07530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M9189_07540	COG1216	Glycosyl transferase, family 2
M9189_07545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9189_07565	COG0110	maltose O-acetyltransferase activity
M9189_07575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M9189_07580	COG3328	transposase activity
M9189_07600	COG0714	Associated with various cellular activities
M9189_07620	COG2304	oxidoreductase activity
M9189_07640	COG0326	Molecular chaperone. Has ATPase activity
M9189_07670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9189_07670	COG2111	Na H antiporter
M9189_07675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9189_07675	COG2111	Na H antiporter
M9189_07680	COG1006	Multisubunit Na H antiporter MnhC subunit
M9189_07685	COG0651	ATP synthesis coupled electron transport
M9189_07690	COG1863	multisubunit Na H antiporter MnhE subunit
M9189_07695	COG2212	antiporter activity
M9189_07700	COG1320	monovalent cation:proton antiporter activity
M9189_07705	COG1213	nucleotidyl transferase
M9189_07715	COG1012	belongs to the aldehyde dehydrogenase family
M9189_07720	COG1960	acyl-CoA dehydrogenase activity
M9189_07725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M9189_07730	COG2086	electron transfer activity
M9189_07735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M9189_07745	COG1132	(ABC) transporter
M9189_07755	COG1030	water channel activity
M9189_07780	COG0179	Fumarylacetoacetate (FAA) hydrolase
M9189_07805	COG0671	phosphoesterase, PA-phosphatase related
M9189_07825	COG4717	serine-type aminopeptidase activity
M9189_07830	COG0424	maF-like protein
M9189_07865	COG1373	ATPase (AAA superfamily
M9189_07880	COG1484	DNA-dependent DNA replication
M9189_07885	COG3328	transposase activity
M9189_07895	COG0751	glycine-tRNA ligase activity
M9189_07910	COG1484	DNA-dependent DNA replication
M9189_07920	COG4584	PFAM Integrase catalytic
M9189_07945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9189_07960	COG1484	DNA-dependent DNA replication
M9189_07990	COG3475	LICD family
M9189_08000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M9189_08055	COG1862	Preprotein translocase
M9189_08060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9189_08075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M9189_08075	COG1918	ferrous iron import across plasma membrane
M9189_08090	COG0823	Involved in the tonB-independent uptake of proteins
M9189_08090	COG1506	peptidase
M9189_08095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M9189_08100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M9189_08105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M9189_08110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M9189_08115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M9189_08125	COG0681	Belongs to the peptidase S26 family
M9189_08145	COG1349	DNA-binding transcription factor activity
M9189_08155	COG4213	ABC transporter substrate-binding protein
M9189_08160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M9189_08210	COG0842	Transport permease protein
M9189_08210	COG1131	(ABC) transporter
M9189_08210	COG1716	ATPase activity
M9189_08215	COG0784	Response regulator, receiver
M9189_08215	COG2205	protein histidine kinase activity
M9189_08250	COG0513	Belongs to the DEAD box helicase family
M9189_08255	COG1166	arginine decarboxylase activity
M9189_08275	COG0460	homoserine dehydrogenase
M9189_08275	COG0527	aspartate kinase activity
M9189_08305	COG0737	Belongs to the 5'-nucleotidase family
M9189_08310	COG1522	sequence-specific DNA binding
M9189_08320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9189_08325	COG0037	tRNA processing
M9189_08330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M9189_08335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M9189_08340	COG0436	Aminotransferase
M9189_08345	COG0077	Prephenate dehydratase
M9189_08355	COG5002	protein histidine kinase activity
M9189_08360	COG0745	RESPONSE REGULATOR receiver
M9189_08365	COG3250	beta-galactosidase activity
M9189_08380	COG1380	Effector of murein hydrolase LrgA
M9189_08385	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M9189_08390	COG1575	Belongs to the MenA family. Type 1 subfamily
M9189_08395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M9189_08400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M9189_08410	COG1253	flavin adenine dinucleotide binding
M9189_08420	COG0573	inorganic phosphate transmembrane transporter activity
M9189_08425	COG0581	inorganic phosphate transmembrane transporter activity
M9189_08430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M9189_08445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M9189_08450	COG3279	Response regulator of the LytR AlgR family
M9189_08455	COG3275	phosphorelay sensor kinase activity
M9189_08465	COG0577	efflux transmembrane transporter activity
M9189_08465	COG1136	(ABC) transporter
M9189_08470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_08485	COG0511	ligase activity, forming carbon-carbon bonds
M9189_08500	COG3279	Response regulator of the LytR AlgR family
M9189_08505	COG3275	phosphorelay sensor kinase activity
M9189_08525	COG1169	isochorismate synthase
M9189_08530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M9189_08535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M9189_08550	COG1704	LemA family
M9189_08575	COG4771	TonB-dependent receptor
M9189_08600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M9189_08615	COG1408	metallophosphoesterase
M9189_08620	COG3275	phosphorelay sensor kinase activity
M9189_08625	COG3279	Response regulator of the LytR AlgR family
M9189_08630	COG1970	mechanosensitive ion channel activity
M9189_08660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9189_08665	COG1127	ABC transporter
M9189_08670	COG0488	(ABC) transporter
M9189_08675	COG0667	Aldo Keto reductase
M9189_08685	COG0668	transmembrane transport
M9189_08690	COG2348	transferase activity, transferring amino-acyl groups
M9189_08695	COG0450	alkyl hydroperoxide reductase
M9189_08700	COG2195	Cleaves the N-terminal amino acid of tripeptides
M9189_08705	COG0442	prolyl-tRNA aminoacylation
M9189_08735	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M9189_08740	COG0497	DNA recombination
M9189_08765	COG0156	8-amino-7-oxononanoate synthase activity
M9189_08770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M9189_08790	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9189_08795	COG0567	Dehydrogenase, E1 component
M9189_08805	COG0336	Belongs to the RNA methyltransferase TrmD family
M9189_08810	COG1196	nuclear chromosome segregation
M9189_08815	COG0504	CTP synthase activity
M9189_08820	COG0706	membrane insertase activity
M9189_08825	COG1472	Belongs to the glycosyl hydrolase 3 family
M9189_08830	COG3876	Protein conserved in bacteria
M9189_08840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M9189_08845	COG0085	RNA polymerase activity
M9189_08850	COG0222	ribosome binding
M9189_08855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M9189_08860	COG0081	regulation of translation
M9189_08865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M9189_08885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M9189_08900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M9189_08905	COG4974	Belongs to the 'phage' integrase family
M9189_08910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M9189_08920	COG0733	neurotransmitter:sodium symporter activity
M9189_08925	COG0191	fructose-bisphosphate aldolase activity
M9189_08935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9189_08945	COG2226	methyltransferase
M9189_08950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M9189_08975	COG3850	Histidine kinase
M9189_08975	COG4999	Histidine kinase
M9189_08975	COG2205	protein histidine kinase activity
M9189_08975	COG3437	response regulator, receiver
M9189_08980	COG1649	PFAM Uncharacterised BCR, COG1649
M9189_08990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M9189_08995	COG0385	Bile acid
M9189_09005	COG3250	beta-galactosidase activity
M9189_09010	COG1501	Belongs to the glycosyl hydrolase 31 family
M9189_09015	COG0745	RESPONSE REGULATOR receiver
M9189_09015	COG2205	protein histidine kinase activity
M9189_09015	COG3292	Two component regulator propeller
M9189_09020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M9189_09035	COG4771	TonB-dependent receptor
M9189_09045	COG1629	transport
M9189_09055	COG3291	Pkd domain containing protein
M9189_09060	COG3459	Glycosyltransferase 36 associated
M9189_09065	COG2211	Major facilitator Superfamily
M9189_09080	COG2315	Protein conserved in bacteria
M9189_09085	COG0792	nuclease activity
M9189_09090	COG1619	proteins homologs of microcin C7 resistance protein MccF
M9189_09095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9189_09095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9189_09105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M9189_09115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M9189_09140	COG1082	Xylose isomerase domain protein TIM barrel
M9189_09155	COG2382	esterase
M9189_09155	COG3693	PFAM glycoside hydrolase, family 10
M9189_09160	COG1472	Belongs to the glycosyl hydrolase 3 family
M9189_09165	COG2382	esterase
M9189_09165	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_09165	COG3693	PFAM glycoside hydrolase, family 10
M9189_09170	COG0745	RESPONSE REGULATOR receiver
M9189_09170	COG3292	Two component regulator propeller
M9189_09170	COG2205	protein histidine kinase activity
M9189_09180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9189_09190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M9189_09195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M9189_09205	COG0574	Belongs to the PEP-utilizing enzyme family
M9189_09205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9189_09215	COG0674	pyruvate-flavodoxin oxidoreductase activity
M9189_09215	COG1013	pyruvate-flavodoxin oxidoreductase activity
M9189_09215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M9189_09215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M9189_09275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M9189_09280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M9189_09340	COG1678	Uncharacterized ACR, COG1678
M9189_09355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M9189_09395	COG4974	Belongs to the 'phage' integrase family
M9189_09410	COG3738	Protein conserved in bacteria
M9189_09440	COG4152	abc transporter atp-binding protein
M9189_09455	COG2234	aminopeptidase activity
M9189_09565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_09635	COG3250	beta-galactosidase activity
M9189_09680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M9189_09685	COG1648	precorrin-2 dehydrogenase activity
M9189_09685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M9189_09690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M9189_09695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M9189_09705	COG1959	2 iron, 2 sulfur cluster binding
M9189_09715	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_09725	COG3250	beta-galactosidase activity
M9189_09730	COG0708	Exodeoxyribonuclease III
M9189_09735	COG0823	Involved in the tonB-independent uptake of proteins
M9189_09735	COG1506	peptidase
M9189_09745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M9189_09760	COG1785	Belongs to the alkaline phosphatase family
M9189_09770	COG4206	TonB-dependent receptor
M9189_09770	COG1629	transport
M9189_09780	COG1269	ATP hydrolysis coupled proton transport
M9189_09795	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M9189_09825	COG3344	reverse transcriptase
M9189_09830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M9189_09830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M9189_09835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9189_09840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9189_09845	COG1501	Belongs to the glycosyl hydrolase 31 family
M9189_09855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M9189_09860	COG1238	metal cluster binding
M9189_09865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M9189_09875	COG1136	(ABC) transporter
M9189_09880	COG2096	Adenosyltransferase
M9189_09895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9189_09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9189_09910	COG0517	IMP dehydrogenase activity
M9189_09910	COG0516	GMP reductase activity
M9189_09955	COG3012	SEC-C Motif Domain Protein
M9189_09960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M9189_09970	COG1230	cation diffusion facilitator family transporter
M9189_09975	COG1904	glucuronate isomerase
M9189_09985	COG0800	Aldolase
M9189_10010	COG1609	Transcriptional regulator
M9189_10015	COG1082	Xylose isomerase domain protein TIM barrel
M9189_10020	COG1501	Belongs to the glycosyl hydrolase 31 family
M9189_10025	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_10035	COG1501	Belongs to the glycosyl hydrolase 31 family
M9189_10040	COG3507	Belongs to the glycosyl hydrolase 43 family
M9189_10055	COG2382	esterase
M9189_10075	COG0702	epimerase
M9189_10080	COG1629	transport
M9189_10090	COG4771	TonB-dependent receptor
M9189_10110	COG3384	dioxygenase
M9189_10115	COG2353	YceI-like domain
M9189_10120	COG0475	glutathione-regulated potassium exporter activity
M9189_10120	COG0589	response to stress
M9189_10135	COG2272	Belongs to the type-B carboxylesterase lipase family
M9189_10160	COG4771	TonB-dependent receptor
M9189_10170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9189_10175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_10180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9189_10190	COG1595	DNA-templated transcription, initiation
M9189_10230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9189_10235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M9189_10245	COG0363	glucosamine-6-phosphate deaminase activity
M9189_10250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M9189_10255	COG2205	protein histidine kinase activity
M9189_10255	COG0784	Response regulator, receiver
M9189_10265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M9189_10275	COG0482	sulfurtransferase activity
M9189_10285	COG4771	TonB-dependent receptor
M9189_10290	COG0592	DNA-directed DNA polymerase activity
M9189_10305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9189_10315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M9189_10330	COG0848	biopolymer transport protein
M9189_10335	COG0811	peptide transport
M9189_10340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M9189_10360	COG2197	response regulator
M9189_10370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M9189_10385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M9189_10400	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M9189_10405	COG4206	TonB-dependent receptor
M9189_10405	COG1629	transport
M9189_10425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M9189_10430	COG1554	hydrolase, family 65, central catalytic
M9189_10435	COG0366	Alpha amylase catalytic
M9189_10440	COG0366	Alpha amylase catalytic
M9189_10445	COG0783	Belongs to the Dps family
M9189_10455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M9189_10460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M9189_10480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M9189_10485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M9189_10530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M9189_10545	COG0463	Glycosyl transferase, family 2
M9189_10545	COG1216	Glycosyl transferase, family 2
M9189_10550	COG0463	Glycosyl transferase, family 2
M9189_10550	COG1216	Glycosyl transferase, family 2
M9189_10570	COG0110	maltose O-acetyltransferase activity
M9189_10590	COG1132	(ABC) transporter
M9189_10645	COG0242	peptide deformylase activity
M9189_10650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M9189_10660	COG0339	signal peptide processing
M9189_10680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_10685	COG1473	amidohydrolase
M9189_10695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M9189_10710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M9189_10710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9189_10720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M9189_10725	COG1435	thymidine kinase activity
M9189_10735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M9189_10745	COG1011	Hydrolase
M9189_10750	COG0305	Participates in initiation and elongation during chromosome replication
M9189_10755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M9189_10760	COG0745	RESPONSE REGULATOR receiver
M9189_10760	COG3292	Two component regulator propeller
M9189_10760	COG2205	protein histidine kinase activity
M9189_10765	COG0017	Asparaginyl-tRNA synthetase
M9189_10775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9189_10785	COG0343	queuine tRNA-ribosyltransferase activity
M9189_10795	COG1595	DNA-templated transcription, initiation
M9189_10800	COG0357	Ribosomal RNA small subunit methyltransferase G
M9189_10805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M9189_10815	COG0564	pseudouridine synthase activity
M9189_10820	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9189_10825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M9189_10840	COG0067	glutamate synthase
M9189_10840	COG0069	glutamate synthase activity
M9189_10840	COG0070	glutamate synthase
M9189_10845	COG0367	asparagine synthase
M9189_10855	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M9189_10910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9189_10915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9189_10930	COG0824	Thioesterase
M9189_10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9189_10955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9189_10960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9189_10965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9189_10970	COG0649	NAD binding
M9189_10975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9189_10975	COG0649	NAD binding
M9189_10980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M9189_10990	COG0839	Belongs to the complex I subunit 6 family
M9189_10995	COG0713	ATP synthesis coupled electron transport
M9189_11000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9189_11005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9189_11020	COG4771	TonB-dependent receptor
M9189_11035	COG1028	Short-chain dehydrogenase reductase Sdr
M9189_11050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9189_11055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9189_11065	COG1131	(ABC) transporter
M9189_11075	COG1879	ABC-type sugar transport system periplasmic component
M9189_11095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9189_11105	COG0217	transcriptional regulatory protein
M9189_11115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M9189_11125	COG4206	TonB-dependent receptor
M9189_11145	COG0612	Peptidase, M16
M9189_11155	COG0716	FMN binding
M9189_11180	COG3385	transposase activity
M9189_11185	COG3385	transposase activity
M9189_11190	COG4124	Belongs to the glycosyl hydrolase 26 family
M9189_11210	COG4771	TonB-dependent receptor
M9189_11220	COG0662	Cupin 2, conserved barrel domain protein
M9189_11220	COG2207	Transcriptional regulator
M9189_11225	COG0228	four-way junction DNA binding
M9189_11230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M9189_11240	COG2171	N-acyltransferase activity
M9189_11250	COG3345	alpha-galactosidase
M9189_11260	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M9189_11270	COG2211	Major facilitator Superfamily
M9189_11295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M9189_11310	COG1136	(ABC) transporter
M9189_11315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9189_11320	COG3385	transposase activity
M9189_11325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9189_11335	COG1136	(ABC) transporter
M9189_11335	COG0577	efflux transmembrane transporter activity
M9189_11340	COG3385	transposase activity
M9189_11355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M9189_11375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M9189_11385	COG1560	Kdo2-lipid A biosynthetic process
M9189_11395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M9189_11400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9189_11415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M9189_11420	COG1278	Cold shock
M9189_11435	COG2843	Capsule synthesis protein
M9189_11440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M9189_11445	COG0739	heme binding
M9189_11455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M9189_11475	COG1704	LemA family
M9189_11490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M9189_11505	COG1477	protein flavinylation
M9189_11510	COG2871	sodium ion transport
M9189_11515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M9189_11525	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M9189_11530	COG1805	sodium ion transport
M9189_11535	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M9189_11580	COG0084	hydrolase, TatD family'
M9189_11585	COG0252	asparaginase activity
M9189_11590	COG0811	peptide transport
M9189_11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_11630	COG1309	transcriptional regulator
M9189_11645	COG0302	gtp cyclohydrolase
M9189_11655	COG0534	Mate efflux family protein
M9189_11660	COG0071	Belongs to the small heat shock protein (HSP20) family
M9189_11665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M9189_11670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M9189_11685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M9189_11690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9189_11695	COG1120	ATPase activity
M9189_11720	COG1196	nuclear chromosome segregation
M9189_11725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M9189_11750	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
M9189_11755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M9189_11760	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M9189_11765	COG0406	alpha-ribazole phosphatase activity
M9189_11770	COG1492	cobalamin metabolic process
M9189_11775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M9189_11785	COG1252	NADH dehydrogenase
M9189_11800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M9189_11835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M9189_11845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M9189_11850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9189_11855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9189_11860	COG0571	ribonuclease III activity
M9189_11890	COG0481	GTPase activity
M9189_11895	COG0459	protein refolding
M9189_11900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M9189_11925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M9189_11935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M9189_11940	COG2151	metal-sulfur cluster biosynthetic enzyme
M9189_11945	COG2166	iron-sulfur cluster assembly
M9189_11950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M9189_11955	COG0719	Fe-S assembly protein
M9189_11960	COG0396	ATPase activity
M9189_11965	COG0719	Fe-S assembly protein
M9189_11970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9189_11975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M9189_11975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9189_11980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9189_11985	COG0587	DNA-directed DNA polymerase activity
M9189_12020	COG3385	transposase activity
M9189_12050	COG4942	peptidase
M9189_12055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M9189_12060	COG0750	zinc metalloprotease
M9189_12065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9189_12075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9189_12080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M9189_12085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M9189_12090	COG0195	Participates in both transcription termination and antitermination
M9189_12095	COG0779	Required for maturation of 30S ribosomal subunits
M9189_12105	COG0632	four-way junction helicase activity
M9189_12115	COG0509	glycine decarboxylation via glycine cleavage system
M9189_12120	COG2204	response regulator
M9189_12130	COG0745	RESPONSE REGULATOR receiver
M9189_12135	COG0802	atpase or kinase
M9189_12140	COG0686	Belongs to the AlaDH PNT family
M9189_12145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M9189_12145	COG0316	Belongs to the HesB IscA family
M9189_12150	COG0489	protein tyrosine kinase activity
M9189_12160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M9189_12170	COG1774	PSP1 C-terminal conserved region
M9189_12175	COG0470	DNA polymerase III
M9189_12180	COG0731	radical SAM domain protein
M9189_12180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9189_12210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M9189_12220	COG0557	exoribonuclease II activity
M9189_12225	COG0126	phosphoglycerate kinase activity
M9189_12240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M9189_12260	COG3341	Caulimovirus viroplasmin
M9189_12260	COG0328	RNA-DNA hybrid ribonuclease activity
M9189_12275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9189_12285	COG0215	cysteine-tRNA ligase activity
M9189_12290	COG2234	aminopeptidase activity
M9189_12295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M9189_12300	COG3591	Belongs to the peptidase S1B family
M9189_12305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M9189_12315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9189_12330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M9189_12345	COG2252	PERMEase
M9189_12375	COG0750	zinc metalloprotease
M9189_12380	COG1127	ABC transporter
M9189_12385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9189_12410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9189_12430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M9189_12435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M9189_12440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M9189_12450	COG0297	glycogen (starch) synthase activity
M9189_12460	COG0307	riboflavin synthase, alpha
M9189_12485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M9189_12490	COG0363	glucosamine-6-phosphate deaminase activity
M9189_12500	COG0268	Binds directly to 16S ribosomal RNA
M9189_12510	COG2003	Belongs to the UPF0758 family
M9189_12520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M9189_12525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M9189_12525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M9189_12530	COG0616	signal peptide processing
M9189_12535	COG1663	tetraacyldisaccharide 4'-kinase activity
M9189_12550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M9189_12555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M9189_12560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M9189_12595	COG0784	Response regulator, receiver
M9189_12595	COG5002	protein histidine kinase activity
M9189_12595	COG2205	protein histidine kinase activity
M9189_12605	COG0151	Belongs to the GarS family
M9189_12625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9189_12640	COG0528	UMP kinase activity
M9189_12645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M9189_12650	COG0052	Belongs to the universal ribosomal protein uS2 family
M9189_12655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M9189_12660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M9189_12675	COG0534	Mate efflux family protein
M9189_12680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M9189_12685	COG1053	succinate dehydrogenase
M9189_12720	COG1381	Involved in DNA repair and RecF pathway recombination
M9189_12730	COG2217	Heavy metal translocating P-type atpase
M9189_12735	COG5002	protein histidine kinase activity
M9189_12735	COG0784	Response regulator, receiver
M9189_12735	COG2198	Histidine kinase
M9189_12745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M9189_12755	COG0233	cytoplasmic translational termination
M9189_12765	COG1214	PFAM Peptidase M22, glycoprotease
M9189_12780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9189_12785	COG0577	efflux transmembrane transporter activity
M9189_12785	COG1136	(ABC) transporter
M9189_12790	COG0577	efflux transmembrane transporter activity
M9189_12790	COG1136	(ABC) transporter
M9189_12795	COG1136	(ABC) transporter
M9189_12835	COG1695	Transcriptional regulator
M9189_12840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M9189_12845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M9189_12850	COG4591	ABC-type transport system involved in lipoprotein release permease component
M9189_12855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9189_12860	COG0745	RESPONSE REGULATOR receiver
M9189_12860	COG2972	Histidine kinase
M9189_12865	COG2201	protein-glutamate methylesterase activity
M9189_12870	COG0180	Tryptophanyl-tRNA synthetase
M9189_12875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M9189_12880	COG1595	DNA-templated transcription, initiation