locus-tag	class	description
BleG1_0004	COG3880	PFAM UvrB UvrC protein
BleG1_0005	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BleG1_0006	COG0542	response to heat
BleG1_0007	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BleG1_0008	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BleG1_0009	COG4956	integral membrane protein (PIN domain superfamily)
BleG1_0010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BleG1_0011	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BleG1_0012	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BleG1_0013	COG1045	serine acetyltransferase
BleG1_0014	COG0215	cysteine-tRNA ligase activity
BleG1_0016	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BleG1_0017	COG3688	RNA-binding protein containing a PIN domain
BleG1_0019	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BleG1_0020	COG0250	Participates in transcription elongation, termination and antitermination
BleG1_0021	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BleG1_0022	COG0081	regulation of translation
BleG1_0023	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BleG1_0024	COG0222	ribosome binding
BleG1_0025	COG2813	Specifically methylates the guanine in position
BleG1_0026	COG0085	RNA polymerase activity
BleG1_0027	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BleG1_0028	COG1358	cellular component organization or biogenesis
BleG1_0029	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BleG1_0030	COG0049	tRNA binding
BleG1_0031	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BleG1_0032	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BleG1_0034	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BleG1_0035	COG0088	Forms part of the polypeptide exit tunnel
BleG1_0036	COG0089	rRNA binding
BleG1_0037	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BleG1_0038	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BleG1_0039	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BleG1_0040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BleG1_0041	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BleG1_0042	COG0255	Belongs to the universal ribosomal protein uL29 family
BleG1_0043	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BleG1_0044	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BleG1_0045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BleG1_0046	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BleG1_0047	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BleG1_0048	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BleG1_0049	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BleG1_0050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BleG1_0051	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BleG1_0052	COG1841	ribosomal large subunit assembly
BleG1_0053	COG0200	Binds to the 23S rRNA
BleG1_0054	COG0201	protein transport
BleG1_0055	COG0563	adenylate kinase activity
BleG1_0056	COG0024	Methionine aminopeptidase
BleG1_0057	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BleG1_0058	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BleG1_0059	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BleG1_0060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BleG1_0061	COG0202	RNA polymerase activity
BleG1_0062	COG0203	ribosomal protein L17
BleG1_0063	COG1122	ATPase activity
BleG1_0065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BleG1_0066	COG0101	tRNA pseudouridine synthase activity
BleG1_0067	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BleG1_0068	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BleG1_0074	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_0075	COG3711	transcriptional antiterminator
BleG1_0077	COG0489	protein tyrosine kinase activity
BleG1_0079	COG2194	sulfuric ester hydrolase activity
BleG1_0080	COG0726	polysaccharide deacetylase
BleG1_0088	COG0577	efflux transmembrane transporter activity
BleG1_0088	COG1136	(ABC) transporter
BleG1_0090	COG0784	Response regulator, receiver
BleG1_0090	COG2198	Histidine kinase
BleG1_0090	COG5002	protein histidine kinase activity
BleG1_0092	COG5644	endopeptidase inhibitor activity
BleG1_0093	COG0791	NLP P60 protein
BleG1_0093	COG0741	lytic transglycosylase activity
BleG1_0100	COG0604	alcohol dehydrogenase
BleG1_0113	COG0789	Transcriptional regulator
BleG1_0115	COG0789	Transcriptional regulator
BleG1_0119	COG0488	(ABC) transporter
BleG1_0123	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BleG1_0135	COG0726	polysaccharide deacetylase
BleG1_0144	COG1595	DNA-templated transcription, initiation
BleG1_0145	COG5662	AntiSigma factor
BleG1_0146	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BleG1_0147	COG4856	YbbR-like protein
BleG1_0148	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BleG1_0149	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BleG1_0152	COG1316	TRANSCRIPTIONal
BleG1_0153	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BleG1_0153	COG0456	acetyltransferase
BleG1_0158	COG1619	proteins homologs of microcin C7 resistance protein MccF
BleG1_0159	COG1349	DNA-binding transcription factor activity
BleG1_0160	COG0110	maltose O-acetyltransferase activity
BleG1_0162	COG1535	isochorismatase
BleG1_0162	COG3433	isochorismatase activity
BleG1_0163	COG1078	dGTPase activity
BleG1_0164	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BleG1_0166	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0167	COG0789	Transcriptional regulator
BleG1_0169	COG0655	NAD(P)H dehydrogenase (quinone) activity
BleG1_0171	COG0180	Tryptophanyl-tRNA synthetase
BleG1_0175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_0176	COG2267	carboxylic ester hydrolase activity
BleG1_0177	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BleG1_0181	COG0628	permease
BleG1_0182	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BleG1_0182	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BleG1_0185	COG0456	acetyltransferase
BleG1_0186	COG0789	Transcriptional regulator
BleG1_0187	COG1132	(ABC) transporter
BleG1_0190	COG0604	alcohol dehydrogenase
BleG1_0191	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BleG1_0192	COG1263	PTS System
BleG1_0192	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BleG1_0195	COG4841	protein insertion into membrane
BleG1_0201	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BleG1_0202	COG1984	allophanate hydrolase subunit 2
BleG1_0203	COG4336	lyase activity
BleG1_0204	COG1914	H( )-stimulated, divalent metal cation uptake system
BleG1_0205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BleG1_0206	COG0840	transmembrane signaling receptor activity
BleG1_0207	COG1842	Phage shock protein A
BleG1_0210	COG0640	Transcriptional regulator
BleG1_0211	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BleG1_0212	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BleG1_0214	COG0477	Major facilitator Superfamily
BleG1_0215	COG0583	DNA-binding transcription factor activity
BleG1_0219	COG2066	Belongs to the glutaminase family
BleG1_0220	COG0697	spore germination
BleG1_0228	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BleG1_0231	COG4221	oxidoreductase activity
BleG1_0236	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_0238	COG0667	Aldo Keto reductase
BleG1_0240	COG0789	Transcriptional regulator
BleG1_0241	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BleG1_0247	COG0745	RESPONSE REGULATOR receiver
BleG1_0250	COG1063	alcohol dehydrogenase
BleG1_0251	COG1720	tRNA m6t6A37 methyltransferase activity
BleG1_0252	COG5646	InterPro IPR014922
BleG1_0253	COG1349	DNA-binding transcription factor activity
BleG1_0254	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0255	COG3718	enzyme involved in inositol metabolism
BleG1_0256	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BleG1_0257	COG3962	Belongs to the TPP enzyme family
BleG1_0258	COG1082	Xylose isomerase domain protein TIM barrel
BleG1_0259	COG0673	inositol 2-dehydrogenase activity
BleG1_0260	COG0191	fructose-bisphosphate aldolase activity
BleG1_0261	COG0673	inositol 2-dehydrogenase activity
BleG1_0262	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BleG1_0265	COG0556	nucleotide-excision repair
BleG1_0266	COG1063	alcohol dehydrogenase
BleG1_0268	COG3829	transcription factor binding
BleG1_0268	COG3290	protein histidine kinase activity
BleG1_0269	COG1454	alcohol dehydrogenase
BleG1_0271	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0272	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BleG1_0273	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BleG1_0278	COG0456	acetyltransferase
BleG1_0283	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_0287	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BleG1_0289	COG3634	alkyl hydroperoxide reductase activity
BleG1_0290	COG0450	alkyl hydroperoxide reductase
BleG1_0291	COG0697	spore germination
BleG1_0293	COG0456	acetyltransferase
BleG1_0294	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BleG1_0295	COG1917	Cupin 2, conserved barrel domain protein
BleG1_0297	COG0584	glycerophosphoryl diester phosphodiesterase
BleG1_0300	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_0301	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BleG1_0302	COG1802	Transcriptional regulator
BleG1_0303	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BleG1_0305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BleG1_0306	COG1063	alcohol dehydrogenase
BleG1_0307	COG1312	Catalyzes the dehydration of D-mannonate
BleG1_0308	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_0309	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BleG1_0310	COG0800	Aldolase
BleG1_0311	COG1064	alcohol dehydrogenase
BleG1_0314	COG0673	inositol 2-dehydrogenase activity
BleG1_0317	COG0395	ABC-type sugar transport system, permease component
BleG1_0318	COG4209	transmembrane transport
BleG1_0319	COG1609	Transcriptional regulator
BleG1_0320	COG1228	amidohydrolase
BleG1_0323	COG0402	S-adenosylhomocysteine deaminase activity
BleG1_0324	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BleG1_0325	COG0628	permease
BleG1_0327	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BleG1_0329	COG3655	Transcriptional regulator
BleG1_0332	COG0604	alcohol dehydrogenase
BleG1_0333	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BleG1_0336	COG1309	transcriptional regulator
BleG1_0338	COG0586	Pfam SNARE associated Golgi protein
BleG1_0341	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_0342	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BleG1_0343	COG2011	ABC-type metal ion transport system permease component
BleG1_0345	COG1473	amidohydrolase
BleG1_0347	COG1609	Transcriptional regulator
BleG1_0348	COG0561	phosphatase activity
BleG1_0349	COG1522	sequence-specific DNA binding
BleG1_0354	COG0531	amino acid
BleG1_0355	COG0697	spore germination
BleG1_0357	COG0477	Major facilitator Superfamily
BleG1_0360	COG2409	Drug exporters of the RND superfamily
BleG1_0361	COG5002	protein histidine kinase activity
BleG1_0362	COG0745	RESPONSE REGULATOR receiver
BleG1_0369	COG2197	response regulator
BleG1_0371	COG2217	Heavy metal translocating P-type atpase
BleG1_0374	COG1823	symporter activity
BleG1_0382	COG0473	3-isopropylmalate dehydrogenase activity
BleG1_0387	COG1609	Transcriptional regulator
BleG1_0388	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BleG1_0389	COG1869	D-ribose catabolic process
BleG1_0390	COG1129	ABC transporter
BleG1_0391	COG1172	Belongs to the binding-protein-dependent transport system permease family
BleG1_0392	COG1879	ABC-type sugar transport system periplasmic component
BleG1_0396	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BleG1_0403	COG0346	lactoylglutathione lyase activity
BleG1_0404	COG2112	serine threonine protein kinase
BleG1_0407	COG0697	spore germination
BleG1_0412	COG1335	isochorismatase
BleG1_0419	COG0431	NADPH-dependent FMN reductase
BleG1_0420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BleG1_0422	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BleG1_0423	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BleG1_0424	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_0426	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BleG1_0427	COG2409	Drug exporters of the RND superfamily
BleG1_0438	COG2188	Transcriptional regulator
BleG1_0439	COG1486	melibiose metabolic process
BleG1_0440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BleG1_0441	COG1447	Phosphotransferase system cellobiose-specific component IIA
BleG1_0449	COG0515	serine threonine protein kinase
BleG1_0455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BleG1_0456	COG1132	(ABC) transporter
BleG1_0462	COG5632	N-Acetylmuramoyl-L-alanine amidase
BleG1_0462	COG3409	Peptidoglycan-binding domain 1 protein
BleG1_0463	COG1253	flavin adenine dinucleotide binding
BleG1_0464	COG1253	flavin adenine dinucleotide binding
BleG1_0489	COG1694	Mazg nucleotide pyrophosphohydrolase
BleG1_0491	COG2207	Transcriptional regulator
BleG1_0496	COG0165	Argininosuccinate lyase
BleG1_0497	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BleG1_0504	COG1695	Transcriptional regulator
BleG1_0507	COG1612	heme a metabolic process
BleG1_0510	COG1846	Transcriptional regulator
BleG1_0511	COG0778	Nitroreductase
BleG1_0512	COG3588	fructose-bisphosphate aldolase
BleG1_0513	COG2329	Antibiotic biosynthesis monooxygenase
BleG1_0515	COG0318	PFAM AMP-dependent synthetase and ligase
BleG1_0516	COG0183	Belongs to the thiolase family
BleG1_0518	COG0124	histidyl-tRNA synthetase
BleG1_0519	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BleG1_0524	COG1309	transcriptional regulator
BleG1_0530	COG3279	Response regulator of the LytR AlgR family
BleG1_0533	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BleG1_0534	COG1309	transcriptional regulator
BleG1_0537	COG3711	transcriptional antiterminator
BleG1_0538	COG2190	(PTS) system
BleG1_0538	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BleG1_0538	COG1263	PTS System
BleG1_0539	COG2723	6-phospho-beta-galactosidase activity
BleG1_0543	COG2508	Transcriptional regulator
BleG1_0545	COG2207	Transcriptional regulator
BleG1_0545	COG4753	response regulator
BleG1_0546	COG2972	Histidine kinase
BleG1_0547	COG1653	transport
BleG1_0548	COG1175	transmembrane transport
BleG1_0549	COG0395	ABC-type sugar transport system, permease component
BleG1_0550	COG0445	tRNA wobble uridine modification
BleG1_0553	COG5444	nuclease activity
BleG1_0571	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BleG1_0573	COG4209	transmembrane transport
BleG1_0574	COG0395	ABC-type sugar transport system, permease component
BleG1_0578	COG1472	Belongs to the glycosyl hydrolase 3 family
BleG1_0579	COG2207	Transcriptional regulator
BleG1_0582	COG3764	Sortase (surface protein transpeptidase)
BleG1_0583	COG1959	2 iron, 2 sulfur cluster binding
BleG1_0584	COG4821	SIS domain
BleG1_0588	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_0591	COG1811	Na channel or pump
BleG1_0594	COG3173	Aminoglycoside phosphotransferase
BleG1_0595	COG0402	S-adenosylhomocysteine deaminase activity
BleG1_0598	COG1982	Orn Lys Arg decarboxylase major
BleG1_0600	COG1175	transmembrane transport
BleG1_0601	COG0395	ABC-type sugar transport system, permease component
BleG1_0603	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BleG1_0609	COG0601	transmembrane transport
BleG1_0610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_0614	COG2851	Citrate transporter
BleG1_0616	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BleG1_0617	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BleG1_0618	COG1414	Transcriptional regulator
BleG1_0623	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BleG1_0625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BleG1_0626	COG0471	metal ion transport
BleG1_0627	COG0436	Aminotransferase
BleG1_0628	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BleG1_0629	COG0235	Class ii aldolase
BleG1_0630	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BleG1_0631	COG1850	ribulose-bisphosphate carboxylase activity
BleG1_0633	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BleG1_0646	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BleG1_0647	COG0402	S-adenosylhomocysteine deaminase activity
BleG1_0652	COG1131	(ABC) transporter
BleG1_0654	COG1063	alcohol dehydrogenase
BleG1_0656	COG4335	DNA alkylation repair
BleG1_0657	COG3239	Fatty acid desaturase
BleG1_0658	COG4585	Histidine kinase
BleG1_0659	COG2197	response regulator
BleG1_0662	COG4208	sulfate ABC transporter
BleG1_0664	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BleG1_0665	COG0667	Aldo Keto reductase
BleG1_0666	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BleG1_0668	COG1309	transcriptional regulator
BleG1_0669	COG2814	Major facilitator Superfamily
BleG1_0670	COG1126	abc transporter atp-binding protein
BleG1_0671	COG0765	amino acid transport
BleG1_0672	COG4597	amino acid ABC transporter
BleG1_0673	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BleG1_0677	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BleG1_0681	COG0154	amidase activity
BleG1_0682	COG0179	Fumarylacetoacetate (FAA) hydrolase
BleG1_0683	COG1469	GTP cyclohydrolase I activity
BleG1_0684	COG3443	Belongs to the bacterial solute-binding protein 9 family
BleG1_0685	COG0803	Belongs to the bacterial solute-binding protein 9 family
BleG1_0686	COG1121	(ABC) transporter
BleG1_0687	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BleG1_0694	COG0446	pyridine nucleotide-disulphide oxidoreductase
BleG1_0695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BleG1_0696	COG4297	protein containing double-stranded beta helix domain
BleG1_0701	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_0704	COG0456	acetyltransferase
BleG1_0710	COG2378	regulation of single-species biofilm formation
BleG1_0715	COG1959	2 iron, 2 sulfur cluster binding
BleG1_0716	COG0492	ferredoxin-NADP+ reductase activity
BleG1_0718	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BleG1_0724	COG1988	membrane-bound metal-dependent
BleG1_0725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BleG1_0726	COG0390	transport system, permease component
BleG1_0728	COG0778	Nitroreductase
BleG1_0732	COG4536	flavin adenine dinucleotide binding
BleG1_0733	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BleG1_0734	COG1074	ATP-dependent DNA helicase activity
BleG1_0735	COG2807	transmembrane transport
BleG1_0738	COG1846	Transcriptional regulator
BleG1_0739	COG2153	protein acetylation
BleG1_0740	COG2814	Major facilitator Superfamily
BleG1_0743	COG1388	LysM domain
BleG1_0743	COG3584	3D domain protein
BleG1_0746	COG1175	transmembrane transport
BleG1_0747	COG0395	ABC-type sugar transport system, permease component
BleG1_0748	COG5578	integral membrane protein
BleG1_0750	COG2273	Hydrolase Family 16
BleG1_0751	COG0693	protein deglycase activity
BleG1_0753	COG2971	BadF BadG BcrA BcrD
BleG1_0754	COG1737	Transcriptional regulator
BleG1_0755	COG3876	Protein conserved in bacteria
BleG1_0756	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BleG1_0758	COG1131	(ABC) transporter
BleG1_0763	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BleG1_0764	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BleG1_0765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BleG1_0765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BleG1_0767	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0769	COG0028	Belongs to the TPP enzyme family
BleG1_0770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BleG1_0771	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BleG1_0774	COG1175	transmembrane transport
BleG1_0775	COG3833	ABC-type maltose transport systems, permease component
BleG1_0776	COG0366	Alpha amylase catalytic
BleG1_0777	COG1609	Transcriptional regulator
BleG1_0778	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_0779	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BleG1_0780	COG0569	domain protein
BleG1_0791	COG1302	Protein conserved in bacteria
BleG1_0793	COG0175	sulfate reduction
BleG1_0794	COG2046	Belongs to the sulfate adenylyltransferase family
BleG1_0795	COG0529	Catalyzes the synthesis of activated sulfate
BleG1_0796	COG1587	Uroporphyrinogen-III synthase
BleG1_0796	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BleG1_0798	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BleG1_0798	COG1648	precorrin-2 dehydrogenase activity
BleG1_0799	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BleG1_0800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BleG1_0803	COG1051	belongs to the nudix hydrolase family
BleG1_0807	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BleG1_0808	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BleG1_0809	COG0733	neurotransmitter:sodium symporter activity
BleG1_0812	COG0658	competence protein
BleG1_0812	COG2333	competence protein COMEC
BleG1_0814	COG3209	COG3209 Rhs family protein
BleG1_0818	COG3209	COG3209 Rhs family protein
BleG1_0821	COG3209	COG3209 Rhs family protein
BleG1_0840	COG1914	H( )-stimulated, divalent metal cation uptake system
BleG1_0842	COG2323	membrane
BleG1_0843	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BleG1_0846	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BleG1_0851	COG0583	DNA-binding transcription factor activity
BleG1_0852	COG2855	membrane
BleG1_0857	COG2197	response regulator
BleG1_0858	COG3142	Participates in the control of copper homeostasis
BleG1_0860	COG1682	transport, permease protein
BleG1_0861	COG1134	teichoic acid transport
BleG1_0865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_0867	COG3414	Phosphotransferase system galactitol-specific IIB component
BleG1_0868	COG3775	system Galactitol-specific IIC component
BleG1_0869	COG1063	alcohol dehydrogenase
BleG1_0871	COG1063	alcohol dehydrogenase
BleG1_0872	COG0488	(ABC) transporter
BleG1_0875	COG3448	diguanylate cyclase activity
BleG1_0875	COG4175	Glycine betaine
BleG1_0876	COG2050	protein possibly involved in aromatic compounds catabolism
BleG1_0877	COG1619	proteins homologs of microcin C7 resistance protein MccF
BleG1_0879	COG2197	response regulator
BleG1_0880	COG4585	Histidine kinase
BleG1_0888	COG0583	DNA-binding transcription factor activity
BleG1_0889	COG0473	3-isopropylmalate dehydrogenase activity
BleG1_0890	COG1053	succinate dehydrogenase
BleG1_0893	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_0893	COG2202	Pas domain
BleG1_0895	COG1418	mRNA catabolic process
BleG1_0897	COG1216	Glycosyl transferase, family 2
BleG1_0897	COG0438	transferase activity, transferring glycosyl groups
BleG1_0899	COG2814	Major facilitator Superfamily
BleG1_0901	COG0500	methyltransferase
BleG1_0904	COG0501	Belongs to the peptidase M48B family
BleG1_0905	COG4989	oxidoreductase activity
BleG1_0908	COG1309	transcriptional regulator
BleG1_0912	COG0673	inositol 2-dehydrogenase activity
BleG1_0913	COG1917	Cupin 2, conserved barrel domain protein
BleG1_0913	COG2207	Transcriptional regulator
BleG1_0916	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BleG1_0917	COG1482	cell wall glycoprotein biosynthetic process
BleG1_0919	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_0927	COG1091	dTDP-4-dehydrorhamnose reductase activity
BleG1_0940	COG1940	carbohydrate kinase activity
BleG1_0941	COG4187	Peptidase family M20/M25/M40
BleG1_0942	COG2814	Major facilitator Superfamily
BleG1_0943	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BleG1_0945	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BleG1_0946	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BleG1_0949	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BleG1_0951	COG2252	PERMEase
BleG1_0959	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0962	COG0737	Belongs to the 5'-nucleotidase family
BleG1_0963	COG1073	alpha beta
BleG1_0964	COG0326	Molecular chaperone. Has ATPase activity
BleG1_0965	COG2124	cytochrome p450
BleG1_0966	COG2031	fatty acid transporter
BleG1_0967	COG1454	alcohol dehydrogenase
BleG1_0968	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_0969	COG1510	regulation of RNA biosynthetic process
BleG1_0971	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BleG1_0974	COG2153	protein acetylation
BleG1_0976	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BleG1_0977	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BleG1_0978	COG2059	Chromate
BleG1_0979	COG2059	Chromate
BleG1_0981	COG0789	Transcriptional regulator
BleG1_0984	COG1695	Transcriptional regulator
BleG1_0985	COG3424	synthase
BleG1_0986	COG1755	Isoprenylcysteine carboxyl methyltransferase
BleG1_0989	COG1175	transmembrane transport
BleG1_0990	COG0395	ABC-type sugar transport system, permease component
BleG1_0994	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BleG1_0995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BleG1_0996	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BleG1_0997	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BleG1_0998	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BleG1_0999	COG0047	phosphoribosylformylglycinamidine synthase activity
BleG1_1000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BleG1_1001	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BleG1_1002	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BleG1_1003	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BleG1_1004	COG0138	bifunctional purine biosynthesis protein purh
BleG1_1005	COG0151	Belongs to the GarS family
BleG1_1012	COG0384	phenazine biosynthesis protein PhzF
BleG1_1014	COG4585	Histidine kinase
BleG1_1015	COG2197	response regulator
BleG1_1016	COG1131	(ABC) transporter
BleG1_1020	COG1510	regulation of RNA biosynthetic process
BleG1_1026	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BleG1_1027	COG4496	protein, YerC YecD
BleG1_1028	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BleG1_1031	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BleG1_1034	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_1035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_1036	COG1120	ATPase activity
BleG1_1038	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BleG1_1040	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BleG1_1041	COG0210	DNA helicase
BleG1_1042	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BleG1_1043	COG4851	CamS sex pheromone cAM373 precursor
BleG1_1045	COG2318	DinB family
BleG1_1047	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BleG1_1048	COG0154	amidase activity
BleG1_1049	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BleG1_1050	COG1597	lipid kinase activity
BleG1_1051	COG1349	DNA-binding transcription factor activity
BleG1_1057	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BleG1_1058	COG0686	Belongs to the AlaDH PNT family
BleG1_1059	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BleG1_1059	COG2508	Transcriptional regulator
BleG1_1060	COG1115	amino acid carrier protein
BleG1_1061	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BleG1_1065	COG0024	Methionine aminopeptidase
BleG1_1067	COG1830	Aldolase
BleG1_1068	COG1070	Carbohydrate kinase
BleG1_1070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BleG1_1074	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_1079	COG1595	DNA-templated transcription, initiation
BleG1_1080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BleG1_1084	COG0398	Pfam SNARE associated Golgi protein
BleG1_1085	COG0456	acetyltransferase
BleG1_1091	COG1414	Transcriptional regulator
BleG1_1092	COG0710	3-dehydroquinate dehydratase activity
BleG1_1093	COG1733	regulation of RNA biosynthetic process
BleG1_1095	COG0431	NADPH-dependent FMN reductase
BleG1_1096	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BleG1_1097	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BleG1_1098	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BleG1_1102	COG2814	Major facilitator Superfamily
BleG1_1103	COG1378	Sugar-specific transcriptional regulator TrmB
BleG1_1104	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BleG1_1107	COG1380	Effector of murein hydrolase LrgA
BleG1_1108	COG1346	cytolysis
BleG1_1111	COG1078	dGTPase activity
BleG1_1112	COG3048	D-serine ammonia-lyase activity
BleG1_1113	COG1752	Esterase of the alpha-beta hydrolase superfamily
BleG1_1115	COG0583	DNA-binding transcription factor activity
BleG1_1116	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BleG1_1118	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BleG1_1119	COG1595	DNA-templated transcription, initiation
BleG1_1123	COG1131	(ABC) transporter
BleG1_1124	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BleG1_1125	COG5002	protein histidine kinase activity
BleG1_1127	COG2391	methyltransferase activity
BleG1_1128	COG2113	Glycine betaine
BleG1_1131	COG1597	lipid kinase activity
BleG1_1133	COG0444	Belongs to the ABC transporter superfamily
BleG1_1134	COG4608	Belongs to the ABC transporter superfamily
BleG1_1135	COG0747	negative chemotaxis
BleG1_1136	COG0601	transmembrane transport
BleG1_1137	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_1140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BleG1_1141	COG3973	AAA domain
BleG1_1142	COG2755	lipolytic protein G-D-S-L family
BleG1_1143	COG1132	(ABC) transporter
BleG1_1144	COG1132	(ABC) transporter
BleG1_1146	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1147	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BleG1_1148	COG1115	amino acid carrier protein
BleG1_1149	COG2244	polysaccharide biosynthetic process
BleG1_1150	COG0405	Gamma-glutamyltransferase
BleG1_1151	COG1263	PTS System
BleG1_1151	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BleG1_1152	COG0366	Alpha amylase catalytic
BleG1_1153	COG2188	Transcriptional regulator
BleG1_1154	COG0386	Belongs to the glutathione peroxidase family
BleG1_1155	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BleG1_1156	COG0488	(ABC) transporter
BleG1_1157	COG1349	DNA-binding transcription factor activity
BleG1_1158	COG1105	Belongs to the carbohydrate kinase PfkB family
BleG1_1159	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_1159	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_1159	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_1164	COG1077	Cell shape determining protein MreB Mrl
BleG1_1165	COG3011	Protein conserved in bacteria
BleG1_1168	COG0328	RNA-DNA hybrid ribonuclease activity
BleG1_1168	COG3341	Caulimovirus viroplasmin
BleG1_1169	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_1171	COG0753	catalase activity
BleG1_1174	COG1164	Oligoendopeptidase f
BleG1_1176	COG1294	oxidase, subunit
BleG1_1177	COG1271	oxidase subunit
BleG1_1182	COG0535	radical SAM domain protein
BleG1_1184	COG0406	alpha-ribazole phosphatase activity
BleG1_1185	COG1253	flavin adenine dinucleotide binding
BleG1_1187	COG0726	polysaccharide deacetylase
BleG1_1189	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BleG1_1197	COG1090	epimerase
BleG1_1198	COG2137	regulation of response to DNA damage stimulus
BleG1_1202	COG1988	membrane-bound metal-dependent
BleG1_1203	COG1194	a g-specific adenine glycosylase
BleG1_1207	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1209	COG3557	Belongs to the UPF0374 family
BleG1_1210	COG1132	(ABC) transporter
BleG1_1211	COG4129	membrane
BleG1_1212	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BleG1_1213	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BleG1_1216	COG0735	belongs to the Fur family
BleG1_1237	COG5434	Belongs to the glycosyl hydrolase 28 family
BleG1_1238	COG5434	Belongs to the glycosyl hydrolase 28 family
BleG1_1257	COG4894	glucomannan catabolic process
BleG1_1260	COG0803	Belongs to the bacterial solute-binding protein 9 family
BleG1_1261	COG0584	glycerophosphoryl diester phosphodiesterase
BleG1_1265	COG1575	Belongs to the MenA family. Type 1 subfamily
BleG1_1267	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BleG1_1270	COG3012	SEC-C Motif Domain Protein
BleG1_1270	COG1405	negative regulation of cell septum assembly
BleG1_1271	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BleG1_1272	COG1966	Carbon starvation protein
BleG1_1274	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_1275	COG1131	(ABC) transporter
BleG1_1277	COG1725	Transcriptional regulator
BleG1_1278	COG1131	(ABC) transporter
BleG1_1280	COG1363	Peptidase, m42
BleG1_1281	COG0783	Belongs to the Dps family
BleG1_1283	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BleG1_1284	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BleG1_1291	COG2329	Antibiotic biosynthesis monooxygenase
BleG1_1293	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BleG1_1294	COG2766	serine protein kinase
BleG1_1295	COG0681	Belongs to the peptidase S26 family
BleG1_1296	COG2718	Belongs to the UPF0229 family
BleG1_1297	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BleG1_1298	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BleG1_1300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_1303	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1304	COG2188	Transcriptional regulator
BleG1_1305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BleG1_1306	COG0363	glucosamine-6-phosphate deaminase activity
BleG1_1307	COG2311	Membrane
BleG1_1308	COG0778	Nitroreductase
BleG1_1309	COG3153	acetyltransferase
BleG1_1309	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BleG1_1311	COG1489	DNA binding
BleG1_1312	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BleG1_1313	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BleG1_1314	COG2719	SpoVR family
BleG1_1315	COG1132	(ABC) transporter
BleG1_1316	COG1132	(ABC) transporter
BleG1_1317	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BleG1_1318	COG0501	Belongs to the peptidase M48B family
BleG1_1319	COG1704	LemA family
BleG1_1320	COG1960	acyl-CoA dehydrogenase activity
BleG1_1321	COG0439	Biotin carboxylase
BleG1_1322	COG0511	ligase activity, forming carbon-carbon bonds
BleG1_1323	COG1024	Enoyl-CoA hydratase
BleG1_1324	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BleG1_1326	COG3842	ATPase activity
BleG1_1327	COG2508	Transcriptional regulator
BleG1_1330	COG4399	Belongs to the UPF0754 family
BleG1_1331	COG3679	Belongs to the UPF0342 family
BleG1_1332	COG0561	phosphatase activity
BleG1_1335	COG0745	RESPONSE REGULATOR receiver
BleG1_1336	COG2770	Histidine kinase
BleG1_1336	COG2205	protein histidine kinase activity
BleG1_1337	COG3481	metal-dependent phosphohydrolase, HD sub domain
BleG1_1339	COG0494	nUDIX hydrolase
BleG1_1341	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BleG1_1345	COG1846	Transcriptional regulator
BleG1_1346	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BleG1_1347	COG0537	adenosine 5'-monophosphoramidase activity
BleG1_1348	COG1131	(ABC) transporter
BleG1_1349	COG4473	ABC transporter
BleG1_1351	COG0785	Cytochrome C biogenesis protein
BleG1_1352	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BleG1_1353	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BleG1_1354	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BleG1_1355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BleG1_1357	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BleG1_1358	COG4492	Belongs to the UPF0735 family
BleG1_1359	COG0077	Prephenate dehydratase
BleG1_1360	COG1827	regulation of RNA biosynthetic process
BleG1_1361	COG1104	cysteine desulfurase activity
BleG1_1362	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BleG1_1363	COG0157	Belongs to the NadC ModD family
BleG1_1364	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BleG1_1365	COG1388	LysM domain
BleG1_1369	COG0632	four-way junction helicase activity
BleG1_1370	COG2255	four-way junction helicase activity
BleG1_1372	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BleG1_1373	COG0343	queuine tRNA-ribosyltransferase activity
BleG1_1374	COG1862	Preprotein translocase
BleG1_1378	COG2244	polysaccharide biosynthetic process
BleG1_1380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BleG1_1380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BleG1_1381	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BleG1_1381	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BleG1_1382	COG5416	Lipopolysaccharide assembly protein A domain
BleG1_1383	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BleG1_1383	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BleG1_1384	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BleG1_1385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BleG1_1386	COG1490	D-aminoacyl-tRNA deacylase activity
BleG1_1387	COG1609	Transcriptional regulator
BleG1_1389	COG0673	inositol 2-dehydrogenase activity
BleG1_1391	COG0124	histidyl-tRNA synthetase
BleG1_1392	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BleG1_1393	COG0460	homoserine dehydrogenase
BleG1_1395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BleG1_1397	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BleG1_1398	COG1959	2 iron, 2 sulfur cluster binding
BleG1_1399	COG1104	cysteine desulfurase activity
BleG1_1400	COG0482	sulfurtransferase activity
BleG1_1402	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BleG1_1403	COG3881	PFAM PRC-barrel domain
BleG1_1406	COG0628	permease
BleG1_1407	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BleG1_1408	COG4472	Bacterial protein of unknown function (DUF965)
BleG1_1409	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BleG1_1410	COG3906	Belongs to the UPF0473 family
BleG1_1411	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BleG1_1412	COG4122	O-methyltransferase activity
BleG1_1413	COG0572	uridine kinase
BleG1_1414	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BleG1_1416	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BleG1_1419	COG0095	Lipoate-protein ligase
BleG1_1424	COG1587	Uroporphyrinogen-III synthase
BleG1_1425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_1429	COG0776	regulation of translation
BleG1_1430	COG1183	phosphatidylcholine synthase activity
BleG1_1431	COG0688	phosphatidylethanolamine metabolic process
BleG1_1432	COG1320	monovalent cation:proton antiporter activity
BleG1_1433	COG2212	antiporter activity
BleG1_1434	COG1863	multisubunit Na H antiporter MnhE subunit
BleG1_1435	COG0651	ATP synthesis coupled electron transport
BleG1_1436	COG1006	Multisubunit Na H antiporter MnhC subunit
BleG1_1437	COG2111	Na H antiporter
BleG1_1438	COG2111	Na H antiporter
BleG1_1438	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BleG1_1441	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BleG1_1442	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BleG1_1443	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BleG1_1444	COG1534	Rna-binding protein
BleG1_1445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BleG1_1446	COG1713	HD superfamily hydrolase involved in NAD metabolism
BleG1_1447	COG0799	negative regulation of ribosome biogenesis
BleG1_1448	COG2996	Protein conserved in bacteria
BleG1_1449	COG2226	methyltransferase
BleG1_1450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BleG1_1451	COG1555	photosystem II stabilization
BleG1_1451	COG1596	polysaccharide export
BleG1_1452	COG2131	deaminase
BleG1_1453	COG0658	competence protein
BleG1_1453	COG2333	competence protein COMEC
BleG1_1455	COG1466	dna polymerase III delta subunit
BleG1_1456	COG0268	Binds directly to 16S ribosomal RNA
BleG1_1457	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BleG1_1459	COG0481	GTPase activity
BleG1_1460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BleG1_1461	COG1420	regulation of RNA biosynthetic process
BleG1_1462	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BleG1_1463	COG0443	Heat shock 70 kDa protein
BleG1_1464	COG0484	heat shock protein binding
BleG1_1465	COG2264	protein methyltransferase activity
BleG1_1466	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BleG1_1467	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BleG1_1468	COG2226	methyltransferase
BleG1_1469	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BleG1_1470	COG0667	Aldo Keto reductase
BleG1_1472	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BleG1_1473	COG1610	YqeY-like protein
BleG1_1474	COG1030	water channel activity
BleG1_1475	COG4864	UPF0365 protein
BleG1_1479	COG1702	phosphate starvation-inducible protein PhoH
BleG1_1480	COG1480	7TM receptor with intracellular HD hydrolase
BleG1_1481	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BleG1_1482	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BleG1_1483	COG0295	cytidine deaminase activity
BleG1_1484	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BleG1_1486	COG1381	Involved in DNA repair and RecF pathway recombination
BleG1_1487	COG0752	glycyl-tRNA synthetase alpha subunit
BleG1_1488	COG0751	glycine-tRNA ligase activity
BleG1_1489	COG0517	IMP dehydrogenase activity
BleG1_1490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BleG1_1491	COG1671	Belongs to the UPF0178 family
BleG1_1492	COG0358	DNA primase activity
BleG1_1493	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BleG1_1495	COG2384	SAM-dependent methyltransferase
BleG1_1496	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BleG1_1497	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BleG1_1498	COG1329	Transcriptional regulator
BleG1_1500	COG0513	Belongs to the DEAD box helicase family
BleG1_1501	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BleG1_1503	COG4191	Histidine kinase
BleG1_1505	COG1121	(ABC) transporter
BleG1_1506	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BleG1_1507	COG0735	belongs to the Fur family
BleG1_1509	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BleG1_1511	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BleG1_1513	COG4086	secreted protein
BleG1_1515	COG0704	Plays a role in the regulation of phosphate uptake
BleG1_1521	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BleG1_1523	COG0477	Major facilitator Superfamily
BleG1_1524	COG0768	penicillin binding
BleG1_1528	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BleG1_1529	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BleG1_1531	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BleG1_1533	COG0457	Tetratricopeptide repeat
BleG1_1533	COG0705	Rhomboid family
BleG1_1534	COG0697	spore germination
BleG1_1538	COG1940	carbohydrate kinase activity
BleG1_1539	COG1027	Aspartate ammonia-lyase
BleG1_1540	COG0352	thiamine-phosphate diphosphorylase activity
BleG1_1542	COG2022	thiamine diphosphate biosynthetic process
BleG1_1543	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BleG1_1544	COG0351	phosphomethylpyrimidine kinase
BleG1_1547	COG0011	TIGRFAM Protein of
BleG1_1548	COG2153	protein acetylation
BleG1_1549	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BleG1_1550	COG2382	esterase
BleG1_1552	COG1396	sequence-specific DNA binding
BleG1_1553	COG0114	fumarate hydratase activity
BleG1_1554	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BleG1_1556	COG4191	Histidine kinase
BleG1_1557	COG1280	lysine exporter protein (LysE YggA)
BleG1_1558	COG3403	YqcI/YcgG family
BleG1_1559	COG4129	membrane
BleG1_1560	COG1376	ErfK ybiS ycfS ynhG family protein
BleG1_1563	COG2195	Cleaves the N-terminal amino acid of tripeptides
BleG1_1567	COG0517	IMP dehydrogenase activity
BleG1_1570	COG2861	carbohydrate metabolic process
BleG1_1571	COG0789	Transcriptional regulator
BleG1_1573	COG0527	aspartate kinase activity
BleG1_1575	COG0300	oxidoreductase activity
BleG1_1576	COG0367	asparagine synthase
BleG1_1577	COG0398	Pfam SNARE associated Golgi protein
BleG1_1581	COG1562	ergosterol biosynthetic process
BleG1_1582	COG2171	N-acyltransferase activity
BleG1_1587	COG2190	(PTS) system
BleG1_1588	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BleG1_1589	COG1850	ribulose-bisphosphate carboxylase activity
BleG1_1590	COG1968	undecaprenyl-diphosphatase activity
BleG1_1591	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BleG1_1593	COG0494	nUDIX hydrolase
BleG1_1594	COG1300	Membrane
BleG1_1595	COG0735	belongs to the Fur family
BleG1_1598	COG2186	Transcriptional regulator
BleG1_1599	COG0277	FAD linked oxidase domain protein
BleG1_1600	COG0247	lactate metabolic process
BleG1_1601	COG0579	oxidoreductase
BleG1_1602	COG0824	Thioesterase
BleG1_1602	COG1250	3-hydroxyacyl-CoA dehydrogenase
BleG1_1604	COG3246	L-lysine catabolic process to acetate
BleG1_1605	COG1510	regulation of RNA biosynthetic process
BleG1_1606	COG1125	glycine betaine transport
BleG1_1606	COG0517	IMP dehydrogenase activity
BleG1_1607	COG1174	glycine betaine transport
BleG1_1608	COG1732	Glycine betaine
BleG1_1613	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BleG1_1615	COG1082	Xylose isomerase domain protein TIM barrel
BleG1_1617	COG4974	Belongs to the 'phage' integrase family
BleG1_1618	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BleG1_1620	COG3871	stress protein (general stress protein 26)
BleG1_1621	COG1764	response to oxidative stress
BleG1_1623	COG2814	Major facilitator Superfamily
BleG1_1625	COG1686	Belongs to the peptidase S11 family
BleG1_1627	COG2172	sigma factor antagonist activity
BleG1_1630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BleG1_1633	COG0697	spore germination
BleG1_1634	COG0019	diaminopimelate decarboxylase activity
BleG1_1635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BleG1_1636	COG0583	DNA-binding transcription factor activity
BleG1_1638	COG2079	MmgE PrpD family protein
BleG1_1639	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BleG1_1641	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_1642	COG0488	(ABC) transporter
BleG1_1643	COG0656	L-ascorbic acid biosynthetic process
BleG1_1644	COG2133	pyrroloquinoline quinone binding
BleG1_1649	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BleG1_1650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BleG1_1651	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BleG1_1652	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_1652	COG2202	Pas domain
BleG1_1654	COG4876	unkown
BleG1_1655	COG1960	acyl-CoA dehydrogenase activity
BleG1_1660	COG1175	transmembrane transport
BleG1_1661	COG0395	ABC-type sugar transport system, permease component
BleG1_1662	COG5578	integral membrane protein
BleG1_1663	COG3534	alpha-L-arabinofuranosidase
BleG1_1666	COG0371	Dehydrogenase
BleG1_1668	COG1069	ribulokinase activity
BleG1_1669	COG2160	L-arabinose isomerase activity
BleG1_1670	COG4213	ABC transporter substrate-binding protein
BleG1_1672	COG4214	carbohydrate transport
BleG1_1673	COG1486	melibiose metabolic process
BleG1_1674	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_1677	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BleG1_1679	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BleG1_1680	COG2226	methyltransferase
BleG1_1681	COG3583	domain protein
BleG1_1681	COG3584	3D domain protein
BleG1_1682	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BleG1_1683	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BleG1_1684	COG1011	Hydrolase
BleG1_1685	COG4721	ABC-type cobalt transport system, permease component
BleG1_1686	COG1122	ATPase activity
BleG1_1688	COG2094	Belongs to the DNA glycosylase MPG family
BleG1_1691	COG3844	kynureninase activity
BleG1_1693	COG0542	response to heat
BleG1_1695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BleG1_1698	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BleG1_1699	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BleG1_1700	COG0626	cystathionine gamma-synthase activity
BleG1_1701	COG0708	Exodeoxyribonuclease III
BleG1_1703	COG0217	transcriptional regulatory protein
BleG1_1708	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BleG1_1709	COG2151	metal-sulfur cluster biosynthetic enzyme
BleG1_1710	COG0702	epimerase
BleG1_1711	COG1757	Na H antiporter
BleG1_1712	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BleG1_1714	COG1175	transmembrane transport
BleG1_1715	COG0395	ABC-type sugar transport system, permease component
BleG1_1716	COG1472	Belongs to the glycosyl hydrolase 3 family
BleG1_1718	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BleG1_1719	COG1473	amidohydrolase
BleG1_1720	COG1473	amidohydrolase
BleG1_1723	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BleG1_1725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BleG1_1726	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BleG1_1727	COG2508	Transcriptional regulator
BleG1_1728	COG1288	antiporter activity
BleG1_1729	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BleG1_1730	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_1730	COG2202	Pas domain
BleG1_1733	COG1414	Transcriptional regulator
BleG1_1734	COG0800	Aldolase
BleG1_1735	COG4948	Mandelate Racemase Muconate Lactonizing
BleG1_1736	COG2610	gluconate transmembrane transporter activity
BleG1_1741	COG1033	growth of symbiont in host cell
BleG1_1741	COG2409	Drug exporters of the RND superfamily
BleG1_1743	COG1733	regulation of RNA biosynthetic process
BleG1_1747	COG0747	negative chemotaxis
BleG1_1748	COG0601	transmembrane transport
BleG1_1750	COG0444	Belongs to the ABC transporter superfamily
BleG1_1751	COG4608	Belongs to the ABC transporter superfamily
BleG1_1755	COG3850	Histidine kinase
BleG1_1755	COG5002	protein histidine kinase activity
BleG1_1756	COG0745	RESPONSE REGULATOR receiver
BleG1_1766	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BleG1_1768	COG2378	regulation of single-species biofilm formation
BleG1_1770	COG1131	(ABC) transporter
BleG1_1771	COG2205	protein histidine kinase activity
BleG1_1772	COG0745	RESPONSE REGULATOR receiver
BleG1_1773	COG3420	alginic acid biosynthetic process
BleG1_1775	COG2205	protein histidine kinase activity
BleG1_1776	COG0745	RESPONSE REGULATOR receiver
BleG1_1777	COG1136	(ABC) transporter
BleG1_1778	COG0577	efflux transmembrane transporter activity
BleG1_1781	COG0463	Glycosyl transferase, family 2
BleG1_1782	COG2274	protein secretion by the type I secretion system
BleG1_1784	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BleG1_1793	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BleG1_1794	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BleG1_1795	COG3842	ATPase activity
BleG1_1796	COG1176	ABC-type spermidine putrescine transport system, permease component I
BleG1_1797	COG1609	Transcriptional regulator
BleG1_1802	COG1904	glucuronate isomerase
BleG1_1803	COG3275	phosphorelay sensor kinase activity
BleG1_1804	COG4753	response regulator
BleG1_1804	COG2207	Transcriptional regulator
BleG1_1805	COG2130	NADP-dependent
BleG1_1806	COG2814	Major facilitator Superfamily
BleG1_1807	COG1714	RDD family
BleG1_1808	COG0488	(ABC) transporter
BleG1_1810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BleG1_1811	COG0384	phenazine biosynthesis protein PhzF
BleG1_1813	COG1609	Transcriptional regulator
BleG1_1814	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BleG1_1815	COG0471	metal ion transport
BleG1_1817	COG1119	ATPase activity
BleG1_1821	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_1822	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_1823	COG1120	ATPase activity
BleG1_1825	COG0733	neurotransmitter:sodium symporter activity
BleG1_1826	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BleG1_1827	COG1131	(ABC) transporter
BleG1_1828	COG3835	regulator
BleG1_1829	COG1253	flavin adenine dinucleotide binding
BleG1_1830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BleG1_1831	COG3842	ATPase activity
BleG1_1832	COG1177	transmembrane transport
BleG1_1833	COG1176	ABC-type spermidine putrescine transport system, permease component I
BleG1_1837	COG3964	amidohydrolase
BleG1_1841	COG2188	Transcriptional regulator
BleG1_1842	COG1115	amino acid carrier protein
BleG1_1843	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BleG1_1844	COG0402	S-adenosylhomocysteine deaminase activity
BleG1_1854	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BleG1_1858	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BleG1_1858	COG0167	dihydroorotate dehydrogenase activity
BleG1_1859	COG0493	'glutamate synthase
BleG1_1864	COG1280	lysine exporter protein (LysE YggA)
BleG1_1866	COG3340	Belongs to the peptidase S51 family
BleG1_1871	COG1621	beta-fructofuranosidase activity
BleG1_1873	COG0395	ABC-type sugar transport system, permease component
BleG1_1874	COG4209	transmembrane transport
BleG1_1875	COG1609	Transcriptional regulator
BleG1_1877	COG2226	methyltransferase
BleG1_1879	COG2610	gluconate transmembrane transporter activity
BleG1_1880	COG3829	transcription factor binding
BleG1_1880	COG3290	protein histidine kinase activity
BleG1_1881	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1886	COG3414	Phosphotransferase system galactitol-specific IIB component
BleG1_1891	COG1609	Transcriptional regulator
BleG1_1893	COG0667	Aldo Keto reductase
BleG1_1896	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BleG1_1896	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BleG1_1898	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BleG1_1899	COG0277	FAD linked oxidase domain protein
BleG1_1902	COG0318	PFAM AMP-dependent synthetase and ligase
BleG1_1904	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1905	COG1414	Transcriptional regulator
BleG1_1909	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_1911	COG0662	Cupin 2, conserved barrel domain protein
BleG1_1916	COG0747	negative chemotaxis
BleG1_1917	COG4608	Belongs to the ABC transporter superfamily
BleG1_1919	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_1920	COG0601	transmembrane transport
BleG1_1921	COG1309	transcriptional regulator
BleG1_1922	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BleG1_1923	COG1794	racemase activity, acting on amino acids and derivatives
BleG1_1926	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BleG1_1926	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BleG1_1928	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_1929	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BleG1_1930	COG1360	Flagellar Motor Protein
BleG1_1931	COG0628	permease
BleG1_1932	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BleG1_1933	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BleG1_1934	COG0187	DNA topoisomerase II activity
BleG1_1935	COG1832	CoA-binding protein
BleG1_1936	COG1174	glycine betaine transport
BleG1_1937	COG0517	IMP dehydrogenase activity
BleG1_1937	COG1125	glycine betaine transport
BleG1_1938	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_1941	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BleG1_1942	COG4841	protein insertion into membrane
BleG1_1944	COG1070	Carbohydrate kinase
BleG1_1946	COG0116	Belongs to the methyltransferase superfamily
BleG1_1948	COG0328	RNA-DNA hybrid ribonuclease activity
BleG1_1949	COG3599	regulation of cell shape
BleG1_1950	COG4474	Belongs to the UPF0398 family
BleG1_1952	COG3359	exonuclease
BleG1_1953	COG1205	dead DEAH box helicase
BleG1_1953	COG1111	helicase
BleG1_1956	COG0400	carboxylic ester hydrolase activity
BleG1_1960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BleG1_1965	COG0493	'glutamate synthase
BleG1_1966	COG0069	glutamate synthase activity
BleG1_1966	COG0067	glutamate synthase
BleG1_1966	COG0070	glutamate synthase
BleG1_1970	COG3428	Bacterial PH domain
BleG1_1971	COG3402	PFAM membrane-flanked domain
BleG1_1973	COG1413	lyase activity
BleG1_1978	COG1234	tRNA 3'-trailer cleavage
BleG1_1980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BleG1_1983	COG0789	Transcriptional regulator
BleG1_1986	COG3331	DNA recombination
BleG1_1987	COG4499	WXG100 protein secretion system (Wss), protein YukC
BleG1_1987	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BleG1_1988	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BleG1_1990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BleG1_1991	COG3935	DnaD domain protein
BleG1_1992	COG0017	Asparaginyl-tRNA synthetase
BleG1_1996	COG0402	S-adenosylhomocysteine deaminase activity
BleG1_1997	COG1199	ATP-dependent helicase activity
BleG1_1997	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BleG1_1999	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BleG1_2000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BleG1_2001	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BleG1_2003	COG0617	tRNA 3'-terminal CCA addition
BleG1_2004	COG0438	transferase activity, transferring glycosyl groups
BleG1_2005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BleG1_2006	COG1803	Methylglyoxal synthase
BleG1_2007	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BleG1_2008	COG1694	Mazg nucleotide pyrophosphohydrolase
BleG1_2009	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_2010	COG2738	Putative neutral zinc metallopeptidase
BleG1_2012	COG4347	Protein of unknown function (DUF1405)
BleG1_2014	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BleG1_2015	COG0723	plastoquinol--plastocyanin reductase activity
BleG1_2017	COG5582	Belongs to the UPF0302 family
BleG1_2018	COG0457	Tetratricopeptide repeat
BleG1_2019	COG0287	Prephenate dehydrogenase
BleG1_2020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BleG1_2021	COG0159	tryptophan synthase activity
BleG1_2022	COG0133	tryptophan synthase activity
BleG1_2023	COG0135	phosphoribosylanthranilate isomerase activity
BleG1_2024	COG0134	indole-3-glycerol-phosphate synthase activity
BleG1_2025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BleG1_2027	COG4401	Chorismate mutase type I
BleG1_2028	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BleG1_2029	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BleG1_2030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BleG1_2031	COG0105	UTP biosynthetic process
BleG1_2032	COG0142	geranyltranstransferase activity
BleG1_2033	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BleG1_2034	COG2226	methyltransferase
BleG1_2037	COG0302	gtp cyclohydrolase
BleG1_2038	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BleG1_2042	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BleG1_2043	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BleG1_2044	COG1160	GTP binding
BleG1_2046	COG0539	negative regulation of cytoplasmic translation
BleG1_2047	COG0204	Acyl-transferase
BleG1_2048	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BleG1_2049	COG2959	enzyme of heme biosynthesis
BleG1_2050	COG3409	Peptidoglycan-binding domain 1 protein
BleG1_2050	COG3773	Cell wall hydrolase
BleG1_2051	COG0646	methionine synthase
BleG1_2051	COG1410	methionine synthase
BleG1_2052	COG0646	methionine synthase
BleG1_2052	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BleG1_2053	COG0626	cystathionine gamma-synthase activity
BleG1_2055	COG2339	peptidase activity
BleG1_2057	COG0492	ferredoxin-NADP+ reductase activity
BleG1_2058	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BleG1_2061	COG5002	protein histidine kinase activity
BleG1_2062	COG0745	RESPONSE REGULATOR receiver
BleG1_2063	COG4862	establishment of competence for transformation
BleG1_2065	COG1473	amidohydrolase
BleG1_2069	COG1396	sequence-specific DNA binding
BleG1_2072	COG0514	ATP-dependent DNA helicase (RecQ)
BleG1_2073	COG4955	Helix-turn-helix domain
BleG1_2075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BleG1_2078	COG1120	ATPase activity
BleG1_2079	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_2080	COG5002	protein histidine kinase activity
BleG1_2081	COG0745	RESPONSE REGULATOR receiver
BleG1_2082	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BleG1_2083	COG1333	cytochrome c biogenesis protein
BleG1_2084	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BleG1_2085	COG1187	pseudouridine synthase activity
BleG1_2086	COG0700	Nucleoside recognition
BleG1_2087	COG2715	membrane protein required for spore maturation
BleG1_2088	COG1686	Belongs to the peptidase S11 family
BleG1_2090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BleG1_2093	COG2323	membrane
BleG1_2096	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BleG1_2097	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BleG1_2098	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BleG1_2099	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BleG1_2101	COG2116	formate transmembrane transporter activity
BleG1_2102	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BleG1_2103	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BleG1_2103	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BleG1_2104	COG0307	riboflavin synthase, alpha
BleG1_2107	COG0508	dehydrogenase complex catalyzes the overall conversion of
BleG1_2108	COG0567	Dehydrogenase, E1 component
BleG1_2113	COG1764	response to oxidative stress
BleG1_2115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BleG1_2117	COG0720	synthase
BleG1_2118	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BleG1_2119	COG2309	aminopeptidase activity
BleG1_2121	COG1254	Belongs to the acylphosphatase family
BleG1_2124	COG1845	cytochrome c oxidase, subunit III
BleG1_2125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BleG1_2128	COG0657	acetylesterase activity
BleG1_2129	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BleG1_2131	COG4841	protein insertion into membrane
BleG1_2133	COG0784	Response regulator, receiver
BleG1_2133	COG0835	chemotaxis
BleG1_2138	COG2200	EAL domain
BleG1_2139	COG2267	carboxylic ester hydrolase activity
BleG1_2142	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BleG1_2143	COG0824	Thioesterase
BleG1_2144	COG0464	growth
BleG1_2150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BleG1_2155	COG1132	(ABC) transporter
BleG1_2156	COG1132	(ABC) transporter
BleG1_2157	COG3763	UPF0154 protein
BleG1_2159	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BleG1_2160	COG4224	UPF0291 protein
BleG1_2161	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BleG1_2163	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BleG1_2164	COG2814	Major facilitator Superfamily
BleG1_2167	COG0174	glutamine synthetase
BleG1_2168	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BleG1_2169	COG0464	growth
BleG1_2171	COG1923	regulation of RNA biosynthetic process
BleG1_2172	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BleG1_2173	COG2136	Putative SAM-dependent methyltransferase
BleG1_2173	COG2521	methyltransferase
BleG1_2174	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BleG1_2175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BleG1_2177	COG4550	Control of competence regulator ComK, YlbF/YmcA
BleG1_2178	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BleG1_2180	COG2359	stage V sporulation protein S
BleG1_2181	COG1692	metallophosphoesterase
BleG1_2182	COG1418	mRNA catabolic process
BleG1_2187	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BleG1_2188	COG0513	Belongs to the DEAD box helicase family
BleG1_2189	COG1058	Belongs to the CinA family
BleG1_2189	COG1546	Belongs to the CinA family
BleG1_2190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BleG1_2191	COG1426	Protein conserved in bacteria
BleG1_2194	COG0300	oxidoreductase activity
BleG1_2195	COG0612	Peptidase, M16
BleG1_2196	COG0612	Peptidase, M16
BleG1_2197	COG1674	ftsk spoiiie
BleG1_2199	COG0740	serine-type endopeptidase activity
BleG1_2200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BleG1_2202	COG0527	aspartate kinase activity
BleG1_2203	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BleG1_2204	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BleG1_2205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BleG1_2206	COG1873	PFAM PRC-barrel domain
BleG1_2207	COG0612	Peptidase, M16
BleG1_2208	COG0726	polysaccharide deacetylase
BleG1_2209	COG1185	polyribonucleotide nucleotidyltransferase activity
BleG1_2210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BleG1_2211	COG0196	riboflavin kinase activity
BleG1_2212	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BleG1_2213	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BleG1_2214	COG1550	Protein conserved in bacteria
BleG1_2215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BleG1_2217	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BleG1_2218	COG0195	Participates in both transcription termination and antitermination
BleG1_2219	COG0779	Required for maturation of 30S ribosomal subunits
BleG1_2220	COG2176	DNA-directed DNA polymerase activity
BleG1_2221	COG0442	prolyl-tRNA aminoacylation
BleG1_2222	COG0750	zinc metalloprotease
BleG1_2223	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BleG1_2224	COG4589	Belongs to the CDS family
BleG1_2225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BleG1_2226	COG0233	cytoplasmic translational termination
BleG1_2227	COG0528	UMP kinase activity
BleG1_2228	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BleG1_2229	COG0052	Belongs to the universal ribosomal protein uS2 family
BleG1_2231	COG1191	sigma factor activity
BleG1_2232	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BleG1_2233	COG1776	CheC inhibitor of MCP methylation
BleG1_2234	COG2201	protein-glutamate methylesterase activity
BleG1_2236	COG1419	protein localization to endoplasmic reticulum
BleG1_2237	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BleG1_2238	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BleG1_2239	COG1684	flagellar biosynthetic protein fliR
BleG1_2240	COG1987	bacterial-type flagellum assembly
BleG1_2241	COG1338	Plays a role in the flagellum-specific transport system
BleG1_2242	COG3190	flagellar
BleG1_2243	COG2201	protein-glutamate methylesterase activity
BleG1_2244	COG1776	CheC inhibitor of MCP methylation
BleG1_2244	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BleG1_2245	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BleG1_2248	COG4786	Flagellar basal body rod
BleG1_2249	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BleG1_2253	COG1157	protein secretion by the type III secretion system
BleG1_2254	COG1317	bacterial-type flagellum organization
BleG1_2255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BleG1_2256	COG1766	The M ring may be actively involved in energy transduction
BleG1_2257	COG1677	Flagellar hook-basal body complex protein FliE
BleG1_2258	COG1558	bacterial-type flagellum-dependent cell motility
BleG1_2259	COG1815	bacterial-type flagellum-dependent cell motility
BleG1_2260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BleG1_2261	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BleG1_2262	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BleG1_2263	COG4974	Belongs to the 'phage' integrase family
BleG1_2264	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BleG1_2265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BleG1_2266	COG0758	DNA mediated transformation
BleG1_2267	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BleG1_2268	COG0045	succinate-CoA ligase (ADP-forming) activity
BleG1_2271	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BleG1_2275	COG0335	large ribosomal subunit rRNA binding
BleG1_2276	COG0018	arginyl-trna synthetase
BleG1_2277	COG0336	Belongs to the RNA methyltransferase TrmD family
BleG1_2278	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BleG1_2280	COG1837	Belongs to the UPF0109 family
BleG1_2281	COG0228	four-way junction DNA binding
BleG1_2282	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BleG1_2283	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BleG1_2284	COG0552	protein localization to endoplasmic reticulum
BleG1_2285	COG1196	nuclear chromosome segregation
BleG1_2287	COG0571	ribonuclease III activity
BleG1_2288	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BleG1_2289	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_2290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BleG1_2291	COG0416	fatty acid biosynthetic process
BleG1_2292	COG1349	DNA-binding transcription factor activity
BleG1_2293	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BleG1_2294	COG1760	l-serine dehydratase
BleG1_2295	COG1760	l-serine dehydratase
BleG1_2296	COG1307	EDD domain protein, DegV family
BleG1_2297	COG1461	Dihydroxyacetone kinase
BleG1_2298	COG1302	Protein conserved in bacteria
BleG1_2299	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BleG1_2300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BleG1_2301	COG1162	GTPase activity
BleG1_2302	COG0515	serine threonine protein kinase
BleG1_2302	COG2815	serine threonine protein kinase
BleG1_2304	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BleG1_2304	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BleG1_2305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BleG1_2306	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BleG1_2307	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BleG1_2308	COG1758	RNA polymerase activity
BleG1_2309	COG0194	GDP metabolic process
BleG1_2310	COG2052	Domain of unknown function (DUF370)
BleG1_2311	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BleG1_2313	COG2226	methyltransferase
BleG1_2314	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BleG1_2315	COG0284	orotidine-5'-phosphate decarboxylase activity
BleG1_2316	COG0167	dihydroorotate dehydrogenase activity
BleG1_2317	COG0543	2 iron, 2 sulfur cluster binding
BleG1_2318	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BleG1_2319	COG0505	Belongs to the CarA family
BleG1_2320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BleG1_2321	COG0540	Belongs to the ATCase OTCase family
BleG1_2322	COG2233	PERMEase
BleG1_2323	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BleG1_2324	COG0564	pseudouridine synthase activity
BleG1_2325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BleG1_2326	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BleG1_2327	COG3599	regulation of cell shape
BleG1_2328	COG2302	S4 RNA-binding domain
BleG1_2329	COG0762	integral membrane protein
BleG1_2330	COG1799	cell septum assembly
BleG1_2331	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BleG1_2332	COG1496	oxidoreductase activity
BleG1_2333	COG1873	PFAM PRC-barrel domain
BleG1_2334	COG1191	sigma factor activity
BleG1_2335	COG1191	sigma factor activity
BleG1_2337	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BleG1_2338	COG0849	cell division
BleG1_2339	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BleG1_2340	COG0772	Belongs to the SEDS family
BleG1_2341	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BleG1_2342	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BleG1_2343	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BleG1_2344	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BleG1_2345	COG0768	penicillin binding
BleG1_2346	COG0768	penicillin binding
BleG1_2348	COG0275	rRNA processing
BleG1_2349	COG2001	Belongs to the MraZ family
BleG1_2350	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BleG1_2351	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BleG1_2352	COG0454	-acetyltransferase
BleG1_2354	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BleG1_2355	COG1399	metal-binding, possibly nucleic acid-binding protein
BleG1_2356	COG1323	Belongs to the UPF0348 family
BleG1_2357	COG3480	Lon protease (S16) C-terminal proteolytic domain
BleG1_2358	COG1752	Esterase of the alpha-beta hydrolase superfamily
BleG1_2359	COG3314	Sporulation integral membrane protein YlbJ
BleG1_2360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BleG1_2361	COG0742	ribosomal rna small subunit methyltransferase
BleG1_2363	COG4471	UPF0298 protein
BleG1_2364	COG3679	Belongs to the UPF0342 family
BleG1_2369	COG2340	Cysteine-rich secretory protein family
BleG1_2372	COG2322	membrane
BleG1_2373	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BleG1_2374	COG1845	cytochrome c oxidase, subunit III
BleG1_2375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BleG1_2376	COG2010	Cytochrome c
BleG1_2376	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BleG1_2377	COG1612	heme a metabolic process
BleG1_2378	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BleG1_2379	COG4838	Belongs to the UPF0358 family
BleG1_2380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BleG1_2381	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BleG1_2383	COG1217	gtp-binding protein TYPA
BleG1_2386	COG0483	inositol monophosphate 1-phosphatase activity
BleG1_2388	COG4493	Belongs to the UPF0637 family
BleG1_2389	COG4476	Belongs to the UPF0223 family
BleG1_2390	COG1982	Orn Lys Arg decarboxylase major
BleG1_2391	COG0726	polysaccharide deacetylase
BleG1_2392	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_2394	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_2395	COG0601	transmembrane transport
BleG1_2397	COG4608	Belongs to the ABC transporter superfamily
BleG1_2398	COG0444	Belongs to the ABC transporter superfamily
BleG1_2400	COG0508	dehydrogenase complex catalyzes the overall conversion of
BleG1_2401	COG0022	dehydrogenase e1 component
BleG1_2403	COG0497	DNA recombination
BleG1_2405	COG0242	peptide deformylase activity
BleG1_2406	COG5503	Protein of unknown function (DUF1447)
BleG1_2407	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BleG1_2408	COG0668	transmembrane transport
BleG1_2410	COG1473	amidohydrolase
BleG1_2411	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BleG1_2412	COG2171	N-acyltransferase activity
BleG1_2414	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BleG1_2415	COG0668	transmembrane transport
BleG1_2418	COG0628	permease
BleG1_2419	COG0702	epimerase
BleG1_2422	COG2608	mercury ion transmembrane transporter activity
BleG1_2423	COG1937	Protein conserved in bacteria
BleG1_2424	COG0561	phosphatase activity
BleG1_2428	COG0508	dehydrogenase complex catalyzes the overall conversion of
BleG1_2429	COG0022	dehydrogenase e1 component
BleG1_2430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BleG1_2431	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BleG1_2433	COG3829	transcription factor binding
BleG1_2433	COG3290	protein histidine kinase activity
BleG1_2436	COG0745	RESPONSE REGULATOR receiver
BleG1_2437	COG0750	zinc metalloprotease
BleG1_2438	COG0497	DNA recombination
BleG1_2439	COG1438	arginine binding
BleG1_2440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BleG1_2441	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BleG1_2442	COG0142	geranyltranstransferase activity
BleG1_2443	COG1722	exodeoxyribonuclease VII activity
BleG1_2444	COG1570	exodeoxyribonuclease VII activity
BleG1_2445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BleG1_2446	COG1302	Protein conserved in bacteria
BleG1_2447	COG0439	Biotin carboxylase
BleG1_2448	COG0511	ligase activity, forming carbon-carbon bonds
BleG1_2458	COG3854	ATPases associated with a variety of cellular activities
BleG1_2460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BleG1_2461	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BleG1_2462	COG0006	proline dipeptidase activity
BleG1_2465	COG1752	Esterase of the alpha-beta hydrolase superfamily
BleG1_2466	COG1321	iron dependent repressor
BleG1_2467	COG1533	DNA photolyase activity
BleG1_2469	COG3973	AAA domain
BleG1_2470	COG0095	Lipoate-protein ligase
BleG1_2471	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BleG1_2472	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BleG1_2473	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BleG1_2474	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BleG1_2475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BleG1_2478	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BleG1_2485	COG4537	Required for transformation and DNA binding
BleG1_2486	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BleG1_2496	COG1459	type II secretion system
BleG1_2497	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BleG1_2498	COG1403	HNH endonuclease
BleG1_2499	COG0210	DNA helicase
BleG1_2500	COG0438	transferase activity, transferring glycosyl groups
BleG1_2500	COG1216	Glycosyl transferase, family 2
BleG1_2501	COG0457	Tetratricopeptide repeat
BleG1_2501	COG0463	Glycosyl transferase, family 2
BleG1_2502	COG0463	Glycosyl transferase, family 2
BleG1_2504	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BleG1_2504	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BleG1_2512	COG0564	pseudouridine synthase activity
BleG1_2513	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BleG1_2514	COG2357	RelA SpoT domain protein
BleG1_2516	COG4116	CYTH
BleG1_2517	COG0741	lytic transglycosylase activity
BleG1_2518	COG2346	COG2346, Truncated hemoglobins
BleG1_2519	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BleG1_2520	COG1164	Oligoendopeptidase f
BleG1_2522	COG4862	establishment of competence for transformation
BleG1_2523	COG1393	Belongs to the ArsC family
BleG1_2524	COG0456	acetyltransferase
BleG1_2527	COG1272	protein, Hemolysin III
BleG1_2528	COG1418	mRNA catabolic process
BleG1_2529	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BleG1_2530	COG0180	Tryptophanyl-tRNA synthetase
BleG1_2531	COG1846	Transcriptional regulator
BleG1_2534	COG5504	Zn-dependent protease
BleG1_2535	COG1072	(Pantothenic acid kinase))
BleG1_2536	COG2340	Cysteine-rich secretory protein family
BleG1_2537	COG3409	Peptidoglycan-binding domain 1 protein
BleG1_2537	COG3773	Cell wall hydrolase
BleG1_2539	COG0617	tRNA 3'-terminal CCA addition
BleG1_2539	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BleG1_2539	COG3620	sequence-specific DNA binding
BleG1_2540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BleG1_2541	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BleG1_2544	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BleG1_2548	COG2267	carboxylic ester hydrolase activity
BleG1_2550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BleG1_2551	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BleG1_2552	COG0505	Belongs to the CarA family
BleG1_2553	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BleG1_2554	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BleG1_2555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BleG1_2556	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BleG1_2557	COG1999	signal sequence binding
BleG1_2558	COG3336	cytochrome c oxidase
BleG1_2559	COG0561	phosphatase activity
BleG1_2563	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BleG1_2566	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_2567	COG1073	alpha beta
BleG1_2569	COG1054	Belongs to the UPF0176 family
BleG1_2571	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BleG1_2572	COG1834	amidinotransferase
BleG1_2574	COG0367	asparagine synthase
BleG1_2575	COG0835	chemotaxis
BleG1_2576	COG0643	Histidine kinase
BleG1_2576	COG2198	Histidine kinase
BleG1_2578	COG0704	Plays a role in the regulation of phosphate uptake
BleG1_2579	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BleG1_2580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BleG1_2581	COG0581	inorganic phosphate transmembrane transporter activity
BleG1_2582	COG0573	inorganic phosphate transmembrane transporter activity
BleG1_2583	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BleG1_2584	COG2318	DinB family
BleG1_2586	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BleG1_2587	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BleG1_2590	COG1228	amidohydrolase
BleG1_2591	COG2002	toxin-antitoxin pair type II binding
BleG1_2592	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BleG1_2593	COG2868	ribosomal protein
BleG1_2594	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BleG1_2595	COG1530	ribonuclease E activity
BleG1_2596	COG1994	Peptidase M50
BleG1_2598	COG0667	Aldo Keto reductase
BleG1_2599	COG1268	BioY protein
BleG1_2600	COG0315	cyclic pyranopterin monophosphate synthase activity
BleG1_2601	COG2894	cell division
BleG1_2602	COG0850	regulation of cytokinetic process
BleG1_2603	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BleG1_2604	COG1792	Involved in formation and maintenance of cell shape
BleG1_2605	COG1077	Cell shape determining protein MreB Mrl
BleG1_2606	COG2003	Belongs to the UPF0758 family
BleG1_2607	COG0424	maF-like protein
BleG1_2608	COG0823	Involved in the tonB-independent uptake of proteins
BleG1_2608	COG1506	peptidase
BleG1_2608	COG4946	Tricorn protease homolog
BleG1_2610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BleG1_2611	COG0285	dihydrofolate synthase activity
BleG1_2612	COG0525	valine-tRNA ligase activity
BleG1_2617	COG1388	LysM domain
BleG1_2617	COG1388	LysM domain
BleG1_2618	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BleG1_2619	COG0113	porphobilinogen synthase activity
BleG1_2621	COG0181	hydroxymethylbilane synthase activity
BleG1_2622	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BleG1_2623	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BleG1_2624	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BleG1_2625	COG0470	DNA polymerase III
BleG1_2625	COG1067	ATP-dependent peptidase activity
BleG1_2626	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BleG1_2627	COG0544	peptidyl-prolyl cis-trans isomerase activity
BleG1_2628	COG1477	protein flavinylation
BleG1_2628	COG0457	Tetratricopeptide repeat
BleG1_2629	COG0066	3-isopropylmalate dehydratase activity
BleG1_2630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BleG1_2631	COG0473	3-isopropylmalate dehydrogenase activity
BleG1_2632	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BleG1_2633	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BleG1_2634	COG0440	acetolactate synthase activity
BleG1_2635	COG0028	Belongs to the TPP enzyme family
BleG1_2636	COG0129	dihydroxy-acid dehydratase activity
BleG1_2638	COG0110	maltose O-acetyltransferase activity
BleG1_2642	COG0622	Phosphoesterase
BleG1_2643	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BleG1_2644	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BleG1_2645	COG5401	PFAM Sporulation and spore germination
BleG1_2646	COG1054	Belongs to the UPF0176 family
BleG1_2648	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BleG1_2649	COG1846	Transcriptional regulator
BleG1_2650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BleG1_2651	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_2652	COG2197	response regulator
BleG1_2653	COG0824	Thioesterase
BleG1_2654	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BleG1_2655	COG1053	succinate dehydrogenase
BleG1_2656	COG2009	succinate dehydrogenase
BleG1_2658	COG0322	excinuclease ABC activity
BleG1_2659	COG3118	belongs to the thioredoxin family
BleG1_2660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BleG1_2661	COG2086	electron transfer activity
BleG1_2662	COG1024	Enoyl-CoA hydratase
BleG1_2663	COG1309	transcriptional regulator
BleG1_2664	COG0318	PFAM AMP-dependent synthetase and ligase
BleG1_2665	COG3766	membrane
BleG1_2666	COG1193	negative regulation of DNA recombination
BleG1_2667	COG1796	DNA polymerase
BleG1_2667	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BleG1_2668	COG1286	toxin biosynthetic process
BleG1_2669	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BleG1_2670	COG0072	phenylalanine-tRNA ligase activity
BleG1_2671	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BleG1_2672	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BleG1_2675	COG1363	Peptidase, m42
BleG1_2677	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BleG1_2678	COG3162	membrane
BleG1_2679	COG0398	Pfam SNARE associated Golgi protein
BleG1_2681	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BleG1_2682	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BleG1_2683	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BleG1_2684	COG0577	efflux transmembrane transporter activity
BleG1_2685	COG1136	(ABC) transporter
BleG1_2686	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BleG1_2690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BleG1_2692	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BleG1_2693	COG1484	DNA-dependent DNA replication
BleG1_2694	COG3611	Membrane attachment protein
BleG1_2695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BleG1_2697	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BleG1_2698	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BleG1_2699	COG0237	dephospho-CoA kinase activity
BleG1_2700	COG1971	Probably functions as a manganese efflux pump
BleG1_2701	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BleG1_2702	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BleG1_2702	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BleG1_2703	COG5002	protein histidine kinase activity
BleG1_2704	COG0745	RESPONSE REGULATOR receiver
BleG1_2705	COG1522	sequence-specific DNA binding
BleG1_2707	COG0039	L-malate dehydrogenase activity
BleG1_2708	COG0538	isocitrate dehydrogenase activity
BleG1_2709	COG0372	Belongs to the citrate synthase family
BleG1_2710	COG3030	protein affecting phage T7 exclusion by the F plasmid
BleG1_2712	COG0205	6-phosphofructokinase activity
BleG1_2713	COG0825	malonyl-CoA metabolic process
BleG1_2714	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BleG1_2715	COG2186	Transcriptional regulator
BleG1_2716	COG0281	malic enzyme
BleG1_2717	COG0587	DNA-directed DNA polymerase activity
BleG1_2720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BleG1_2722	COG4109	DRTGG domain
BleG1_2724	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BleG1_2725	COG0006	proline dipeptidase activity
BleG1_2727	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_2729	COG0165	Argininosuccinate lyase
BleG1_2730	COG0137	argininosuccinate synthase activity
BleG1_2732	COG3481	metal-dependent phosphohydrolase, HD sub domain
BleG1_2733	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BleG1_2734	COG0827	DNA restriction-modification system
BleG1_2735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BleG1_2736	COG3874	Sporulation protein YtfJ
BleG1_2738	COG1714	RDD family
BleG1_2739	COG0616	signal peptide processing
BleG1_2740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BleG1_2742	COG0301	tRNA thio-modification
BleG1_2743	COG1104	cysteine desulfurase activity
BleG1_2744	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BleG1_2745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BleG1_2746	COG1309	transcriptional regulator
BleG1_2747	COG1956	GAF domain-containing protein
BleG1_2748	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BleG1_2749	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BleG1_2751	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BleG1_2752	COG0454	-acetyltransferase
BleG1_2753	COG0517	IMP dehydrogenase activity
BleG1_2754	COG0123	including yeast histone deacetylase and acetoin utilization protein
BleG1_2755	COG1609	Transcriptional regulator
BleG1_2756	COG1605	Chorismate mutase
BleG1_2756	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BleG1_2757	COG4980	gas vesicle protein
BleG1_2759	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BleG1_2760	COG1674	ftsk spoiiie
BleG1_2761	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BleG1_2762	COG4848	Belongs to the UPF0354 family
BleG1_2763	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BleG1_2766	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BleG1_2767	COG1363	Peptidase, m42
BleG1_2769	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BleG1_2771	COG0510	thiamine kinase activity
BleG1_2772	COG0788	formyltetrahydrofolate deformylase activity
BleG1_2773	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_2775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BleG1_2776	COG1349	DNA-binding transcription factor activity
BleG1_2777	COG1187	pseudouridine synthase activity
BleG1_2778	COG0772	Belongs to the SEDS family
BleG1_2779	COG0772	Belongs to the SEDS family
BleG1_2780	COG2244	polysaccharide biosynthetic process
BleG1_2781	COG3386	PFAM SMP-30 Gluconolaconase
BleG1_2782	COG0432	Pfam Uncharacterised protein family UPF0047
BleG1_2783	COG1473	amidohydrolase
BleG1_2784	COG2081	HI0933 family
BleG1_2785	COG0495	leucyl-tRNA aminoacylation
BleG1_2786	COG2814	Major facilitator Superfamily
BleG1_2787	COG1242	4 iron, 4 sulfur cluster binding
BleG1_2788	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BleG1_2789	COG0288	reversible hydration of carbon dioxide
BleG1_2791	COG2267	carboxylic ester hydrolase activity
BleG1_2792	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BleG1_2793	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BleG1_2794	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BleG1_2795	COG1506	peptidase
BleG1_2796	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BleG1_2797	COG1116	anion transmembrane transporter activity
BleG1_2798	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BleG1_2799	COG0494	nUDIX hydrolase
BleG1_2800	COG2814	Major facilitator Superfamily
BleG1_2803	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BleG1_2804	COG1428	Deoxynucleoside kinase
BleG1_2805	COG1428	Deoxynucleoside kinase
BleG1_2807	COG4607	ABC-type enterochelin transport system periplasmic component
BleG1_2808	COG4604	ABC transporter, ATP-binding protein
BleG1_2809	COG4605	iron ion homeostasis
BleG1_2810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BleG1_2811	COG0671	phosphoesterase, PA-phosphatase related
BleG1_2815	COG4846	Membrane protein involved in cytochrome C biogenesis
BleG1_2816	COG0109	protoheme IX farnesyltransferase activity
BleG1_2817	COG1227	inorganic diphosphatase activity
BleG1_2821	COG2610	gluconate transmembrane transporter activity
BleG1_2822	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BleG1_2823	COG3395	kinase activity
BleG1_2824	COG1349	DNA-binding transcription factor activity
BleG1_2851	COG1396	sequence-specific DNA binding
BleG1_2852	COG1396	sequence-specific DNA binding
BleG1_2854	COG1396	sequence-specific DNA binding
BleG1_2873	COG0739	heme binding
BleG1_2873	COG0741	lytic transglycosylase activity
BleG1_2873	COG1196	nuclear chromosome segregation
BleG1_2895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BleG1_2898	COG0673	inositol 2-dehydrogenase activity
BleG1_2899	COG1802	Transcriptional regulator
BleG1_2902	COG0166	Belongs to the GPI family
BleG1_2903	COG1181	Belongs to the D-alanine--D-alanine ligase family
BleG1_2904	COG1979	alcohol dehydrogenase
BleG1_2905	COG2155	Conserved Protein
BleG1_2906	COG1098	S1 RNA binding domain
BleG1_2908	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BleG1_2909	COG0436	Aminotransferase
BleG1_2910	COG1522	sequence-specific DNA binding
BleG1_2911	COG1335	isochorismatase
BleG1_2912	COG1854	S-ribosylhomocysteine lyase activity
BleG1_2913	COG1295	ribonuclease BN
BleG1_2914	COG0776	regulation of translation
BleG1_2915	COG2056	Na+-H+ antiporter family
BleG1_2917	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BleG1_2918	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BleG1_2919	COG3584	3D domain protein
BleG1_2921	COG1252	NADH dehydrogenase
BleG1_2922	COG0492	ferredoxin-NADP+ reductase activity
BleG1_2923	COG0246	Mannitol dehydrogenase
BleG1_2925	COG3711	transcriptional antiterminator
BleG1_2926	COG2213	PTS system mannitol-specific
BleG1_2927	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BleG1_2928	COG0765	amino acid transport
BleG1_2929	COG0316	Belongs to the HesB IscA family
BleG1_2931	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BleG1_2932	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BleG1_2934	COG4844	belongs to the
BleG1_2935	COG1252	NADH dehydrogenase
BleG1_2936	COG4837	Protein of unknown function (DUF1462)
BleG1_2937	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BleG1_2940	COG0083	homoserine kinase activity
BleG1_2941	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BleG1_2942	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BleG1_2943	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BleG1_2945	COG2445	Protein of unknown function DUF86
BleG1_2947	COG4470	Protein conserved in bacteria
BleG1_2949	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BleG1_2950	COG0739	heme binding
BleG1_2951	COG1757	Na H antiporter
BleG1_2954	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BleG1_2955	COG3377	Domain of unknown function (DUF1805)
BleG1_2956	COG0737	Belongs to the 5'-nucleotidase family
BleG1_2957	COG0730	response to heat
BleG1_2958	COG1801	Protein of unknown function DUF72
BleG1_2959	COG0719	Fe-S assembly protein
BleG1_2960	COG0822	iron-sulfur transferase activity
BleG1_2961	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BleG1_2962	COG0719	Fe-S assembly protein
BleG1_2963	COG0396	ATPase activity
BleG1_2965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BleG1_2966	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BleG1_2968	COG1464	Belongs to the NlpA lipoprotein family
BleG1_2969	COG2011	ABC-type metal ion transport system permease component
BleG1_2970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BleG1_2973	COG0509	glycine decarboxylation via glycine cleavage system
BleG1_2974	COG1393	Belongs to the ArsC family
BleG1_2975	COG1960	acyl-CoA dehydrogenase activity
BleG1_2976	COG0183	Belongs to the thiolase family
BleG1_2977	COG1250	3-hydroxyacyl-CoA dehydrogenase
BleG1_2977	COG1024	Enoyl-CoA hydratase
BleG1_2980	COG0753	catalase activity
BleG1_2982	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BleG1_2983	COG3314	Sporulation integral membrane protein YlbJ
BleG1_2985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BleG1_2986	COG2259	Doxx family
BleG1_2987	COG0557	exoribonuclease II activity
BleG1_2988	COG1647	Serine aminopeptidase, S33
BleG1_2990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BleG1_2991	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BleG1_2993	COG0163	prenyltransferase activity
BleG1_2995	COG0148	phosphopyruvate hydratase activity
BleG1_2996	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BleG1_2997	COG0149	triose-phosphate isomerase activity
BleG1_2998	COG0126	phosphoglycerate kinase activity
BleG1_2999	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BleG1_3002	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BleG1_3003	COG0740	serine-type endopeptidase activity
BleG1_3005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_3006	COG1481	regulation of sporulation
BleG1_3007	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BleG1_3008	COG1660	Displays ATPase and GTPase activities
BleG1_3009	COG1051	belongs to the nudix hydrolase family
BleG1_3010	COG0492	ferredoxin-NADP+ reductase activity
BleG1_3012	COG0140	phosphoribosyl-ATP diphosphatase activity
BleG1_3012	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BleG1_3013	COG0107	imidazoleglycerol-phosphate synthase activity
BleG1_3014	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BleG1_3015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BleG1_3016	COG0131	Imidazoleglycerol-phosphate dehydratase
BleG1_3017	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BleG1_3018	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BleG1_3019	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BleG1_3020	COG0110	maltose O-acetyltransferase activity
BleG1_3021	COG0546	phosphoglycolate phosphatase activity
BleG1_3022	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BleG1_3023	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BleG1_3024	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BleG1_3025	COG1950	PFAM Membrane protein of
BleG1_3026	COG1983	PspC domain protein
BleG1_3027	COG3595	metallopeptidase activity
BleG1_3028	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BleG1_3029	COG0556	nucleotide-excision repair
BleG1_3032	COG0793	Belongs to the peptidase S41A family
BleG1_3032	COG3409	Peptidoglycan-binding domain 1 protein
BleG1_3033	COG0739	heme binding
BleG1_3034	COG2177	Part of the ABC transporter FtsEX involved in
BleG1_3035	COG2884	Cell division ATP-binding protein ftsE
BleG1_3036	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BleG1_3036	COG2010	Cytochrome c
BleG1_3037	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BleG1_3038	COG0653	protein targeting
BleG1_3039	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BleG1_3040	COG1278	Cold shock
BleG1_3043	COG1516	flagellar protein fliS
BleG1_3044	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BleG1_3046	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BleG1_3047	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BleG1_3048	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BleG1_3049	COG1256	bacterial-type flagellum assembly
BleG1_3049	COG4786	Flagellar basal body rod
BleG1_3054	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BleG1_3055	COG1307	EDD domain protein, DegV family
BleG1_3058	COG1739	Uncharacterized protein family UPF0029
BleG1_3059	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BleG1_3060	COG2860	membrane
BleG1_3063	COG0601	transmembrane transport
BleG1_3064	COG4608	Belongs to the ABC transporter superfamily
BleG1_3066	COG1522	sequence-specific DNA binding
BleG1_3068	COG4193	domain, Protein
BleG1_3070	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_3070	COG3103	Sh3 type 3 domain protein
BleG1_3070	COG4991	sh3 domain protein
BleG1_3071	COG0463	Glycosyl transferase, family 2
BleG1_3071	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BleG1_3072	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BleG1_3074	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BleG1_3075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BleG1_3078	COG1780	Probably involved in ribonucleotide reductase function
BleG1_3079	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BleG1_3080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BleG1_3081	COG4112	unkown
BleG1_3083	COG3858	chitin binding
BleG1_3083	COG1388	LysM domain
BleG1_3084	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_3089	COG1725	Transcriptional regulator
BleG1_3090	COG1131	(ABC) transporter
BleG1_3092	COG1959	2 iron, 2 sulfur cluster binding
BleG1_3093	COG1408	metallophosphoesterase
BleG1_3095	COG0561	phosphatase activity
BleG1_3096	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BleG1_3097	COG0673	inositol 2-dehydrogenase activity
BleG1_3103	COG3275	phosphorelay sensor kinase activity
BleG1_3105	COG1966	Carbon starvation protein
BleG1_3106	COG3961	Belongs to the TPP enzyme family
BleG1_3107	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BleG1_3107	COG0519	Catalyzes the synthesis of GMP from XMP
BleG1_3108	COG1305	Transglutaminase-like
BleG1_3109	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BleG1_3110	COG0714	Associated with various cellular activities
BleG1_3112	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BleG1_3115	COG0768	penicillin binding
BleG1_3116	COG0778	Nitroreductase
BleG1_3117	COG1126	abc transporter atp-binding protein
BleG1_3118	COG0765	amino acid transport
BleG1_3119	COG0765	amino acid transport
BleG1_3120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BleG1_3122	COG0463	Glycosyl transferase, family 2
BleG1_3124	COG4485	Bacterial membrane protein, YfhO
BleG1_3128	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BleG1_3129	COG2427	Protein of unknown function (DUF1641)
BleG1_3130	COG3383	formate dehydrogenase (NAD+) activity
BleG1_3131	COG2116	formate transmembrane transporter activity
BleG1_3132	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BleG1_3133	COG0314	molybdopterin synthase activity
BleG1_3134	COG1763	Mo-molybdopterin cofactor biosynthetic process
BleG1_3135	COG0303	'Molybdopterin
BleG1_3136	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BleG1_3138	COG0746	molybdenum cofactor guanylyltransferase activity
BleG1_3139	COG0315	cyclic pyranopterin monophosphate synthase activity
BleG1_3140	COG2368	4-hydroxyphenylacetate
BleG1_3141	COG2267	carboxylic ester hydrolase activity
BleG1_3142	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BleG1_3152	COG1279	arginine transmembrane transporter activity
BleG1_3157	COG0459	protein refolding
BleG1_3158	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BleG1_3159	COG1266	CAAX protease self-immunity
BleG1_3161	COG0371	Dehydrogenase
BleG1_3162	COG1464	Belongs to the NlpA lipoprotein family
BleG1_3163	COG2011	ABC-type metal ion transport system permease component
BleG1_3164	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BleG1_3166	COG1174	glycine betaine transport
BleG1_3167	COG0517	IMP dehydrogenase activity
BleG1_3167	COG1125	glycine betaine transport
BleG1_3169	COG0805	protein transport
BleG1_3170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BleG1_3171	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BleG1_3172	COG0488	(ABC) transporter
BleG1_3173	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BleG1_3174	COG0456	acetyltransferase
BleG1_3175	COG1214	PFAM Peptidase M22, glycoprotease
BleG1_3176	COG0802	atpase or kinase
BleG1_3177	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BleG1_3180	COG0626	cystathionine gamma-synthase activity
BleG1_3181	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BleG1_3182	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BleG1_3183	COG1285	pathogenesis
BleG1_3184	COG0586	Pfam SNARE associated Golgi protein
BleG1_3197	COG4152	abc transporter atp-binding protein
BleG1_3200	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_3201	COG2207	Transcriptional regulator
BleG1_3202	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BleG1_3203	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BleG1_3208	COG2409	Drug exporters of the RND superfamily
BleG1_3218	COG3091	SprT-like family
BleG1_3219	COG2183	response to ionizing radiation
BleG1_3221	COG1191	sigma factor activity
BleG1_3222	COG2172	sigma factor antagonist activity
BleG1_3223	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_3224	COG2208	phosphoserine phosphatase activity
BleG1_3225	COG2172	sigma factor antagonist activity
BleG1_3226	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_3227	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_3228	COG2337	Toxic component of a toxin-antitoxin (TA) module
BleG1_3229	COG0864	Transcriptional regulator
BleG1_3230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BleG1_3231	COG0736	holo-[acyl-carrier-protein] synthase activity
BleG1_3232	COG0705	Rhomboid family
BleG1_3235	COG1368	sulfuric ester hydrolase activity
BleG1_3236	COG1876	peptidase activity
BleG1_3238	COG5578	integral membrane protein
BleG1_3242	COG0673	inositol 2-dehydrogenase activity
BleG1_3243	COG1082	Xylose isomerase domain protein TIM barrel
BleG1_3244	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_3246	COG1320	monovalent cation:proton antiporter activity
BleG1_3247	COG2212	antiporter activity
BleG1_3248	COG1863	multisubunit Na H antiporter MnhE subunit
BleG1_3249	COG0651	ATP synthesis coupled electron transport
BleG1_3250	COG1006	Multisubunit Na H antiporter MnhC subunit
BleG1_3251	COG2111	Na H antiporter
BleG1_3252	COG2111	Na H antiporter
BleG1_3252	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BleG1_3253	COG2205	protein histidine kinase activity
BleG1_3255	COG2514	catechol 2,3-dioxygenase activity
BleG1_3256	COG1733	regulation of RNA biosynthetic process
BleG1_3259	COG4608	Belongs to the ABC transporter superfamily
BleG1_3260	COG0791	NLP P60 protein
BleG1_3261	COG1619	proteins homologs of microcin C7 resistance protein MccF
BleG1_3262	COG4166	transmembrane transport
BleG1_3263	COG0444	Belongs to the ABC transporter superfamily
BleG1_3264	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_3265	COG0601	transmembrane transport
BleG1_3266	COG2362	D-Aminopeptidase
BleG1_3267	COG2962	Rard protein
BleG1_3268	COG2706	6-phosphogluconolactonase activity
BleG1_3269	COG0686	Belongs to the AlaDH PNT family
BleG1_3270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BleG1_3270	COG2508	Transcriptional regulator
BleG1_3271	COG0415	Belongs to the DNA photolyase family
BleG1_3273	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BleG1_3274	COG0531	amino acid
BleG1_3275	COG1876	peptidase activity
BleG1_3279	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BleG1_3280	COG0596	Alpha beta hydrolase
BleG1_3281	COG0861	Integral membrane protein TerC family
BleG1_3282	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BleG1_3286	COG1404	Belongs to the peptidase S8 family
BleG1_3287	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BleG1_3289	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BleG1_3290	COG3639	organic phosphonate transmembrane transporter activity
BleG1_3291	COG3639	organic phosphonate transmembrane transporter activity
BleG1_3292	COG0604	alcohol dehydrogenase
BleG1_3294	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BleG1_3298	COG0024	Methionine aminopeptidase
BleG1_3299	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BleG1_3302	COG1846	Transcriptional regulator
BleG1_3304	COG2239	Acts as a magnesium transporter
BleG1_3305	COG1304	FMN binding
BleG1_3307	COG4977	sequence-specific DNA binding
BleG1_3307	COG1917	Cupin 2, conserved barrel domain protein
BleG1_3308	COG1486	melibiose metabolic process
BleG1_3312	COG0395	ABC-type sugar transport system, permease component
BleG1_3313	COG4209	transmembrane transport
BleG1_3314	COG4753	response regulator
BleG1_3314	COG2207	Transcriptional regulator
BleG1_3315	COG2972	Histidine kinase
BleG1_3316	COG1653	transport
BleG1_3318	COG2195	Cleaves the N-terminal amino acid of tripeptides
BleG1_3319	COG1757	Na H antiporter
BleG1_3320	COG0395	ABC-type sugar transport system, permease component
BleG1_3323	COG2207	Transcriptional regulator
BleG1_3325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BleG1_3326	COG1408	metallophosphoesterase
BleG1_3329	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_3330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BleG1_3332	COG2258	MOSC domain
BleG1_3336	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BleG1_3338	COG2084	Dehydrogenase
BleG1_3339	COG2610	gluconate transmembrane transporter activity
BleG1_3340	COG1737	Transcriptional regulator
BleG1_3341	COG0191	fructose-bisphosphate aldolase activity
BleG1_3342	COG0697	spore germination
BleG1_3348	COG1136	(ABC) transporter
BleG1_3348	COG0577	efflux transmembrane transporter activity
BleG1_3349	COG5002	protein histidine kinase activity
BleG1_3349	COG3850	Histidine kinase
BleG1_3350	COG0745	RESPONSE REGULATOR receiver
BleG1_3351	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BleG1_3353	COG1309	transcriptional regulator
BleG1_3354	COG0477	Major facilitator Superfamily
BleG1_3356	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BleG1_3357	COG2340	Cysteine-rich secretory protein family
BleG1_3361	COG1376	ErfK ybiS ycfS ynhG family protein
BleG1_3366	COG1357	PFAM Pentapeptide repeats (8 copies)
BleG1_3367	COG3409	Peptidoglycan-binding domain 1 protein
BleG1_3367	COG5632	N-Acetylmuramoyl-L-alanine amidase
BleG1_3369	COG1113	amino acid transport
BleG1_3371	COG0737	Belongs to the 5'-nucleotidase family
BleG1_3372	COG0438	transferase activity, transferring glycosyl groups
BleG1_3373	COG0438	transferase activity, transferring glycosyl groups
BleG1_3375	COG3397	chitin binding
BleG1_3381	COG5504	Zn-dependent protease
BleG1_3386	COG3842	ATPase activity
BleG1_3387	COG0395	ABC-type sugar transport system, permease component
BleG1_3388	COG1175	transmembrane transport
BleG1_3390	COG0385	Bile acid
BleG1_3392	COG1686	Belongs to the peptidase S11 family
BleG1_3393	COG4509	Sortase family
BleG1_3394	COG1120	ATPase activity
BleG1_3398	COG5386	Cell surface protein
BleG1_3399	COG2329	Antibiotic biosynthesis monooxygenase
BleG1_3402	COG0716	FMN binding
BleG1_3403	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BleG1_3403	COG0551	DNA topoisomerase type I activity
BleG1_3406	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BleG1_3408	COG3192	ethanolamine utilization protein
BleG1_3411	COG1621	beta-fructofuranosidase activity
BleG1_3415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BleG1_3416	COG0523	cobalamin synthesis protein
BleG1_3417	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BleG1_3417	COG0512	Glutamine amidotransferase of anthranilate synthase
BleG1_3421	COG3069	C4-dicarboxylate transmembrane transporter activity
BleG1_3423	COG2226	methyltransferase
BleG1_3428	COG1131	(ABC) transporter
BleG1_3432	COG1302	Protein conserved in bacteria
BleG1_3441	COG0248	Ppx GppA phosphatase
BleG1_3447	COG1132	(ABC) transporter
BleG1_3448	COG1132	(ABC) transporter
BleG1_3452	COG0300	oxidoreductase activity
BleG1_3453	COG1280	lysine exporter protein (LysE YggA)
BleG1_3454	COG1690	Belongs to the RtcB family
BleG1_3456	COG3340	Belongs to the peptidase S51 family
BleG1_3457	COG0346	lactoylglutathione lyase activity
BleG1_3458	COG0400	carboxylic ester hydrolase activity
BleG1_3465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BleG1_3468	COG1609	Transcriptional regulator
BleG1_3470	COG1653	transport
BleG1_3471	COG1175	transmembrane transport
BleG1_3473	COG2357	RelA SpoT domain protein
BleG1_3479	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BleG1_3481	COG1942	4-Oxalocrotonate Tautomerase
BleG1_3483	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BleG1_3484	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BleG1_3485	COG0583	DNA-binding transcription factor activity
BleG1_3487	COG2261	transglycosylase associated protein
BleG1_3488	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BleG1_3491	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BleG1_3496	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BleG1_3497	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BleG1_3498	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BleG1_3499	COG1132	(ABC) transporter
BleG1_3502	COG0010	Belongs to the arginase family
BleG1_3503	COG0019	diaminopimelate decarboxylase activity
BleG1_3509	COG1595	DNA-templated transcription, initiation
BleG1_3511	COG1511	domain protein
BleG1_3512	COG1674	ftsk spoiiie
BleG1_3513	COG4499	WXG100 protein secretion system (Wss), protein YukC
BleG1_3515	COG4842	Belongs to the WXG100 family
BleG1_3524	COG0395	ABC-type sugar transport system, permease component
BleG1_3525	COG1175	transmembrane transport
BleG1_3526	COG2204	response regulator
BleG1_3527	COG2972	Histidine kinase
BleG1_3529	COG2910	NAD(P)H-binding
BleG1_3532	COG1929	Belongs to the glycerate kinase type-1 family
BleG1_3535	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_3536	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BleG1_3538	COG2197	response regulator
BleG1_3539	COG2203	Gaf domain
BleG1_3539	COG4585	Histidine kinase
BleG1_3541	COG1396	sequence-specific DNA binding
BleG1_3543	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BleG1_3543	COG0662	Cupin 2, conserved barrel domain protein
BleG1_3544	COG1091	dTDP-4-dehydrorhamnose reductase activity
BleG1_3547	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BleG1_3548	COG0515	serine threonine protein kinase
BleG1_3548	COG2815	serine threonine protein kinase
BleG1_3552	COG1216	Glycosyl transferase, family 2
BleG1_3555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BleG1_3556	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BleG1_3562	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_3562	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_3562	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_3563	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_3563	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BleG1_3563	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BleG1_3564	COG1105	Belongs to the carbohydrate kinase PfkB family
BleG1_3570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BleG1_3575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BleG1_3575	COG2207	Transcriptional regulator
BleG1_3581	COG1131	(ABC) transporter
BleG1_3585	COG0395	ABC-type sugar transport system, permease component
BleG1_3586	COG1175	transmembrane transport
BleG1_3587	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BleG1_3589	COG0673	inositol 2-dehydrogenase activity
BleG1_3591	COG1917	Cupin 2, conserved barrel domain protein
BleG1_3591	COG2207	Transcriptional regulator
BleG1_3593	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BleG1_3594	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_3595	COG1349	DNA-binding transcription factor activity
BleG1_3596	COG1070	Carbohydrate kinase
BleG1_3597	COG2115	Belongs to the xylose isomerase family
BleG1_3598	COG0395	ABC-type sugar transport system, permease component
BleG1_3599	COG1175	transmembrane transport
BleG1_3601	COG1940	carbohydrate kinase activity
BleG1_3602	COG3507	Belongs to the glycosyl hydrolase 43 family
BleG1_3606	COG1653	transport
BleG1_3607	COG1175	transmembrane transport
BleG1_3608	COG0395	ABC-type sugar transport system, permease component
BleG1_3611	COG4193	domain, Protein
BleG1_3613	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_3615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BleG1_3622	COG0318	PFAM AMP-dependent synthetase and ligase
BleG1_3623	COG1309	transcriptional regulator
BleG1_3625	COG4565	transcriptional regulatory protein
BleG1_3626	COG3290	protein histidine kinase activity
BleG1_3630	COG0395	ABC-type sugar transport system, permease component
BleG1_3631	COG1175	transmembrane transport
BleG1_3634	COG0671	phosphoesterase, PA-phosphatase related
BleG1_3636	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_3638	COG2207	Transcriptional regulator
BleG1_3639	COG1388	LysM domain
BleG1_3640	COG0753	catalase activity
BleG1_3649	COG1528	Iron-storage protein
BleG1_3654	COG2182	Extracellular solute-binding protein
BleG1_3655	COG1175	transmembrane transport
BleG1_3656	COG3833	ABC-type maltose transport systems, permease component
BleG1_3659	COG2814	Major facilitator Superfamily
BleG1_3660	COG0537	adenosine 5'-monophosphoramidase activity
BleG1_3665	COG3250	beta-galactosidase activity
BleG1_3668	COG1175	transmembrane transport
BleG1_3669	COG0395	ABC-type sugar transport system, permease component
BleG1_3670	COG1657	PFAM Prenyltransferase squalene oxidase
BleG1_3674	COG3181	Tripartite tricarboxylate transporter family receptor
BleG1_3675	COG4565	transcriptional regulatory protein
BleG1_3676	COG3290	protein histidine kinase activity
BleG1_3677	COG0318	PFAM AMP-dependent synthetase and ligase
BleG1_3678	COG4464	protein tyrosine phosphatase activity
BleG1_3679	COG0489	protein tyrosine kinase activity
BleG1_3680	COG3944	biosynthesis protein
BleG1_3681	COG1316	TRANSCRIPTIONal
BleG1_3682	COG2076	Multidrug Resistance protein
BleG1_3683	COG2076	Multidrug Resistance protein
BleG1_3685	COG0702	epimerase
BleG1_3686	COG0772	Belongs to the SEDS family
BleG1_3687	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BleG1_3690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BleG1_3691	COG1388	LysM domain
BleG1_3691	COG0791	NLP P60 protein
BleG1_3692	COG0010	Belongs to the arginase family
BleG1_3694	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BleG1_3696	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BleG1_3701	COG4786	Flagellar basal body rod
BleG1_3702	COG4786	Flagellar basal body rod
BleG1_3703	COG1077	Cell shape determining protein MreB Mrl
BleG1_3704	COG1609	Transcriptional regulator
BleG1_3705	COG0739	heme binding
BleG1_3706	COG2385	sporulation resulting in formation of a cellular spore
BleG1_3707	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BleG1_3710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BleG1_3711	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BleG1_3712	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BleG1_3713	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BleG1_3714	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BleG1_3715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BleG1_3716	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BleG1_3717	COG0356	it plays a direct role in the translocation of protons across the membrane
BleG1_3720	COG1404	Belongs to the peptidase S8 family
BleG1_3721	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BleG1_3722	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BleG1_3723	COG4475	Protein of unknown function (DUF436)
BleG1_3724	COG0698	ribose 5-phosphate isomerase
BleG1_3725	COG0840	transmembrane signaling receptor activity
BleG1_3727	COG1971	Probably functions as a manganese efflux pump
BleG1_3729	COG0009	L-threonylcarbamoyladenylate synthase
BleG1_3733	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BleG1_3734	COG0446	pyridine nucleotide-disulphide oxidoreductase
BleG1_3736	COG1435	thymidine kinase activity
BleG1_3737	COG0254	rRNA binding
BleG1_3738	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BleG1_3739	COG1494	fructose-1,6-bisphosphatase
BleG1_3740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BleG1_3741	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BleG1_3742	COG0191	fructose-bisphosphate aldolase activity
BleG1_3745	COG0504	CTP synthase activity
BleG1_3746	COG3343	RNA polymerase activity
BleG1_3748	COG1960	acyl-CoA dehydrogenase activity
BleG1_3749	COG1250	3-hydroxyacyl-CoA dehydrogenase
BleG1_3750	COG0183	Belongs to the thiolase family
BleG1_3751	COG0247	lactate metabolic process
BleG1_3751	COG2181	nitrate reductase activity
BleG1_3752	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BleG1_3753	COG2839	Protein conserved in bacteria
BleG1_3754	COG0018	arginyl-trna synthetase
BleG1_3756	COG0010	Belongs to the arginase family
BleG1_3757	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BleG1_3758	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BleG1_3761	COG1164	Oligoendopeptidase f
BleG1_3765	COG1942	4-Oxalocrotonate Tautomerase
BleG1_3766	COG3465	dGTPase activity
BleG1_3767	COG1078	dGTPase activity
BleG1_3768	COG1301	dicarboxylic acid transport
BleG1_3769	COG0095	Lipoate-protein ligase
BleG1_3770	COG0280	phosphate acetyltransferase
BleG1_3771	COG1024	Enoyl-CoA hydratase
BleG1_3772	COG3253	May function as heme-dependent peroxidase
BleG1_3773	COG0706	membrane insertase activity
BleG1_3775	COG1668	transmembrane transport
BleG1_3776	COG4152	abc transporter atp-binding protein
BleG1_3777	COG3773	Cell wall hydrolase
BleG1_3779	COG2363	Small membrane protein
BleG1_3780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BleG1_3780	COG3153	acetyltransferase
BleG1_3784	COG0004	ammonium transporteR
BleG1_3785	COG5577	PFAM Coat F domain
BleG1_3787	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BleG1_3788	COG3314	Sporulation integral membrane protein YlbJ
BleG1_3789	COG0840	transmembrane signaling receptor activity
BleG1_3790	COG0351	phosphomethylpyrimidine kinase
BleG1_3791	COG2986	histidine ammonia-lyase
BleG1_3795	COG0513	Belongs to the DEAD box helicase family
BleG1_3797	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BleG1_3798	COG0723	plastoquinol--plastocyanin reductase activity
BleG1_3798	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BleG1_3802	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BleG1_3803	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BleG1_3805	COG3493	citrate carrier protein
BleG1_3808	COG2268	Band 7 protein
BleG1_3809	COG1785	Belongs to the alkaline phosphatase family
BleG1_3810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BleG1_3810	COG0551	DNA topoisomerase type I activity
BleG1_3811	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BleG1_3813	COG2814	Major facilitator Superfamily
BleG1_3816	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BleG1_3817	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BleG1_3817	COG1321	iron dependent repressor
BleG1_3818	COG1121	(ABC) transporter
BleG1_3819	COG0803	Belongs to the bacterial solute-binding protein 9 family
BleG1_3820	COG0561	phosphatase activity
BleG1_3821	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BleG1_3826	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BleG1_3827	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BleG1_3828	COG2814	Major facilitator Superfamily
BleG1_3843	COG0860	N-Acetylmuramoyl-L-alanine amidase
BleG1_3845	COG0281	malic enzyme
BleG1_3846	COG3493	citrate carrier protein
BleG1_3847	COG4565	transcriptional regulatory protein
BleG1_3848	COG3290	protein histidine kinase activity
BleG1_3849	COG0753	catalase activity
BleG1_3850	COG1132	(ABC) transporter
BleG1_3852	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BleG1_3853	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BleG1_3854	COG0747	negative chemotaxis
BleG1_3855	COG0601	transmembrane transport
BleG1_3856	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_3857	COG0444	Belongs to the ABC transporter superfamily
BleG1_3858	COG4608	Belongs to the ABC transporter superfamily
BleG1_3864	COG2323	membrane
BleG1_3865	COG1597	lipid kinase activity
BleG1_3866	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BleG1_3868	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BleG1_3868	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BleG1_3871	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BleG1_3874	COG1114	Component of the transport system for branched-chain amino acids
BleG1_3877	COG5002	protein histidine kinase activity
BleG1_3878	COG0745	RESPONSE REGULATOR receiver
BleG1_3880	COG2807	transmembrane transport
BleG1_3881	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_3882	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BleG1_3883	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BleG1_3884	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BleG1_3885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BleG1_3886	COG0471	metal ion transport
BleG1_3887	COG4565	transcriptional regulatory protein
BleG1_3888	COG3290	protein histidine kinase activity
BleG1_3889	COG0697	spore germination
BleG1_3898	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BleG1_3900	COG1215	transferase activity, transferring glycosyl groups
BleG1_3901	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BleG1_3904	COG0668	transmembrane transport
BleG1_3905	COG1366	Belongs to the anti-sigma-factor antagonist family
BleG1_3906	COG0813	purine-nucleoside phosphorylase activity
BleG1_3907	COG0346	lactoylglutathione lyase activity
BleG1_3910	COG0577	efflux transmembrane transporter activity
BleG1_3911	COG1136	(ABC) transporter
BleG1_3912	COG0642	Histidine kinase
BleG1_3913	COG0745	RESPONSE REGULATOR receiver
BleG1_3914	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BleG1_3915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BleG1_3918	COG1657	PFAM Prenyltransferase squalene oxidase
BleG1_3919	COG4149	molybdate abc transporter
BleG1_3920	COG0725	ABC transporter, periplasmic molybdate-binding protein
BleG1_3923	COG0640	Transcriptional regulator
BleG1_3933	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BleG1_3934	COG3285	dna ligase
BleG1_3934	COG1793	dna ligase
BleG1_3936	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BleG1_3938	COG2409	Drug exporters of the RND superfamily
BleG1_3940	COG0579	oxidoreductase
BleG1_3944	COG2040	homocysteine
BleG1_3946	COG0583	DNA-binding transcription factor activity
BleG1_3947	COG2814	Major facilitator Superfamily
BleG1_3953	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BleG1_3957	COG1438	arginine binding
BleG1_3961	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BleG1_3963	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BleG1_3964	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BleG1_3965	COG4853	Protein conserved in bacteria
BleG1_3967	COG5002	protein histidine kinase activity
BleG1_3968	COG0745	RESPONSE REGULATOR receiver
BleG1_3974	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BleG1_3975	COG0305	Participates in initiation and elongation during chromosome replication
BleG1_3976	COG0359	binds to the 23S rRNA
BleG1_3977	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BleG1_3979	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BleG1_3980	COG0629	single-stranded DNA binding
BleG1_3981	COG0360	Binds together with S18 to 16S ribosomal RNA
BleG1_3982	COG0012	GTP binding
BleG1_3983	COG4481	Protein conserved in bacteria
BleG1_3984	COG3949	Membrane
BleG1_3986	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BleG1_3987	COG1475	DNA binding
BleG1_3988	COG1192	Involved in chromosome partitioning
BleG1_3989	COG1475	DNA binding
BleG1_3990	COG0357	Ribosomal RNA small subunit methyltransferase G
BleG1_3991	COG0445	tRNA wobble uridine modification
BleG1_3992	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BleG1_3993	COG1847	R3H domain protein
BleG1_3994	COG0706	membrane insertase activity
BleG1_3995	COG0594	ribonuclease P activity
BleG1_3996	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BleG1_3997	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BleG1_3998	COG0592	DNA-directed DNA polymerase activity
BleG1_3999	COG2501	S4 domain
BleG1_4000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BleG1_4002	COG0187	DNA topoisomerase II activity
BleG1_4003	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BleG1_4005	COG1028	Short-chain dehydrogenase reductase Sdr
BleG1_4010	COG0517	IMP dehydrogenase activity
BleG1_4010	COG0516	GMP reductase activity
BleG1_4011	COG1686	Belongs to the peptidase S11 family
BleG1_4013	COG2508	Transcriptional regulator
BleG1_4014	COG0006	proline dipeptidase activity
BleG1_4016	COG1473	amidohydrolase
BleG1_4018	COG1012	belongs to the aldehyde dehydrogenase family
BleG1_4019	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BleG1_4020	COG0765	amino acid transport
BleG1_4022	COG4608	Belongs to the ABC transporter superfamily
BleG1_4023	COG0444	Belongs to the ABC transporter superfamily
BleG1_4024	COG0601	transmembrane transport
BleG1_4025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BleG1_4028	COG0590	tRNA wobble adenosine to inosine editing
BleG1_4029	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BleG1_4030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BleG1_4031	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BleG1_4039	COG1982	Orn Lys Arg decarboxylase major
BleG1_4040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BleG1_4041	COG3870	Protein conserved in bacteria
BleG1_4042	COG0470	DNA polymerase III
BleG1_4043	COG1774	PSP1 C-terminal conserved region
BleG1_4044	COG4467	Involved in initiation control of chromosome replication
BleG1_4045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BleG1_4046	COG2827	Endonuclease containing a URI domain
BleG1_4047	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BleG1_4048	COG2002	toxin-antitoxin pair type II binding
BleG1_4051	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BleG1_4051	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BleG1_4052	COG0488	(ABC) transporter
BleG1_4055	COG0084	hydrolase, TatD family'
BleG1_4056	COG3583	domain protein
BleG1_4056	COG3584	3D domain protein
BleG1_4057	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BleG1_4058	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BleG1_4060	COG4466	Protein conserved in bacteria
BleG1_4062	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BleG1_4063	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BleG1_4064	COG0251	oxidation-reduction process
BleG1_4065	COG2088	sporulation resulting in formation of a cellular spore
BleG1_4066	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BleG1_4067	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BleG1_4068	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BleG1_4069	COG0193	aminoacyl-tRNA hydrolase activity
BleG1_4071	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BleG1_4072	COG2002	toxin-antitoxin pair type II binding
BleG1_4074	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BleG1_4076	COG2244	polysaccharide biosynthetic process
BleG1_4077	COG3956	TIGRFAM MazG family protein
BleG1_4078	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BleG1_4079	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BleG1_4080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BleG1_4081	COG0492	ferredoxin-NADP+ reductase activity
BleG1_4086	COG1098	S1 RNA binding domain
BleG1_4088	COG2208	phosphoserine phosphatase activity
BleG1_4089	COG2304	oxidoreductase activity
BleG1_4090	COG0515	serine threonine protein kinase
BleG1_4091	COG0037	tRNA processing
BleG1_4092	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BleG1_4093	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BleG1_4094	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BleG1_4095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BleG1_4096	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BleG1_4097	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BleG1_4098	COG0512	Glutamine amidotransferase of anthranilate synthase
BleG1_4099	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BleG1_4100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BleG1_4101	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BleG1_4102	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BleG1_4103	COG1396	sequence-specific DNA binding
BleG1_4104	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family