locus-tag	class	description
MM271_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MM271_00010	COG0592	DNA-directed DNA polymerase activity
MM271_00015	COG2501	S4 domain
MM271_00030	COG0187	DNA topoisomerase II activity
MM271_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MM271_00065	COG0516	GMP reductase activity
MM271_00065	COG0517	IMP dehydrogenase activity
MM271_00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MM271_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MM271_00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MM271_00090	COG1522	sequence-specific DNA binding
MM271_00095	COG0444	Belongs to the ABC transporter superfamily
MM271_00100	COG4608	Belongs to the ABC transporter superfamily
MM271_00110	COG0601	transmembrane transport
MM271_00115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_00120	COG0590	tRNA wobble adenosine to inosine editing
MM271_00125	COG3093	addiction module antidote protein HigA
MM271_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MM271_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MM271_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MM271_00180	COG1982	Orn Lys Arg decarboxylase major
MM271_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MM271_00190	COG3870	Protein conserved in bacteria
MM271_00195	COG0470	DNA polymerase III
MM271_00200	COG1774	PSP1 C-terminal conserved region
MM271_00205	COG4467	Involved in initiation control of chromosome replication
MM271_00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MM271_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MM271_00220	COG2002	toxin-antitoxin pair type II binding
MM271_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM271_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM271_00230	COG0084	hydrolase, TatD family'
MM271_00235	COG3583	domain protein
MM271_00235	COG3584	3D domain protein
MM271_00245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MM271_00255	COG4466	Protein conserved in bacteria
MM271_00265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MM271_00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MM271_00275	COG0251	oxidation-reduction process
MM271_00280	COG2088	sporulation resulting in formation of a cellular spore
MM271_00285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MM271_00290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MM271_00295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MM271_00300	COG0193	aminoacyl-tRNA hydrolase activity
MM271_00310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MM271_00315	COG2002	toxin-antitoxin pair type II binding
MM271_00320	COG2244	polysaccharide biosynthetic process
MM271_00325	COG3956	TIGRFAM MazG family protein
MM271_00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MM271_00345	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MM271_00350	COG1098	S1 RNA binding domain
MM271_00360	COG2208	phosphoserine phosphatase activity
MM271_00365	COG2304	oxidoreductase activity
MM271_00370	COG0515	serine threonine protein kinase
MM271_00375	COG2966	Psort location CytoplasmicMembrane, score
MM271_00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MM271_00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM271_00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MM271_00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MM271_00410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MM271_00415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MM271_00420	COG0512	Glutamine amidotransferase of anthranilate synthase
MM271_00425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MM271_00430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MM271_00435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MM271_00440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MM271_00445	COG1396	sequence-specific DNA binding
MM271_00450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MM271_00455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MM271_00550	COG3880	PFAM UvrB UvrC protein
MM271_00555	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MM271_00560	COG0542	response to heat
MM271_00565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MM271_00570	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MM271_00575	COG4956	integral membrane protein (PIN domain superfamily)
MM271_00580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MM271_00590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MM271_00595	COG1045	serine acetyltransferase
MM271_00600	COG0215	cysteine-tRNA ligase activity
MM271_00610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MM271_00615	COG3688	RNA-binding protein containing a PIN domain
MM271_00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MM271_00630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MM271_00635	COG0250	Participates in transcription elongation, termination and antitermination
MM271_00640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MM271_00645	COG0081	regulation of translation
MM271_00650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MM271_00655	COG0222	ribosome binding
MM271_00660	COG2813	Specifically methylates the guanine in position
MM271_00665	COG0085	RNA polymerase activity
MM271_00670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MM271_00675	COG1358	cellular component organization or biogenesis
MM271_00680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MM271_00685	COG0049	tRNA binding
MM271_00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MM271_00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MM271_00700	COG0051	transcription antitermination factor activity, RNA binding
MM271_00705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MM271_00710	COG0088	Forms part of the polypeptide exit tunnel
MM271_00715	COG0089	rRNA binding
MM271_00720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MM271_00725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MM271_00730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MM271_00735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MM271_00740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MM271_00745	COG0255	Belongs to the universal ribosomal protein uL29 family
MM271_00750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MM271_00755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MM271_00760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MM271_00765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MM271_00770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MM271_00775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MM271_00780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MM271_00785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MM271_00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MM271_00795	COG1841	ribosomal large subunit assembly
MM271_00800	COG0200	Binds to the 23S rRNA
MM271_00805	COG0201	protein transport
MM271_00810	COG0563	adenylate kinase activity
MM271_00815	COG0024	Methionine aminopeptidase
MM271_00825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MM271_00830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MM271_00835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MM271_00840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MM271_00845	COG0202	RNA polymerase activity
MM271_00850	COG0203	ribosomal protein L17
MM271_00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM271_00870	COG0101	tRNA pseudouridine synthase activity
MM271_00875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MM271_00880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MM271_00885	COG5002	protein histidine kinase activity
MM271_00895	COG5002	protein histidine kinase activity
MM271_00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM271_00910	COG0489	protein tyrosine kinase activity
MM271_00920	COG2194	sulfuric ester hydrolase activity
MM271_00925	COG0726	polysaccharide deacetylase
MM271_01005	COG1595	DNA-templated transcription, initiation
MM271_01010	COG5662	AntiSigma factor
MM271_01015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MM271_01020	COG4856	YbbR-like protein
MM271_01025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM271_01030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MM271_01035	COG0745	RESPONSE REGULATOR receiver
MM271_01040	COG2205	protein histidine kinase activity
MM271_01045	COG1136	(ABC) transporter
MM271_01050	COG0577	efflux transmembrane transporter activity
MM271_01090	COG0484	heat shock protein binding
MM271_01100	COG1476	TRANSCRIPTIONal
MM271_01110	COG1846	Transcriptional regulator
MM271_01115	COG0477	Major facilitator Superfamily
MM271_01125	COG0640	Transcriptional regulator
MM271_01130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MM271_01135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MM271_01150	COG1842	Phage shock protein A
MM271_01155	COG1585	Membrane protein implicated in regulation of membrane protease activity
MM271_01160	COG2268	Band 7 protein
MM271_01170	COG1472	Belongs to the glycosyl hydrolase 3 family
MM271_01200	COG0436	Aminotransferase
MM271_01205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM271_01210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MM271_01215	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MM271_01220	COG1850	ribulose-bisphosphate carboxylase activity
MM271_01225	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MM271_01230	COG0235	Class ii aldolase
MM271_01235	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MM271_01250	COG0586	Pfam SNARE associated Golgi protein
MM271_01255	COG0589	response to stress
MM271_01260	COG1595	DNA-templated transcription, initiation
MM271_01270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_01275	COG2239	Acts as a magnesium transporter
MM271_01280	COG0697	spore germination
MM271_01295	COG3842	ATPase activity
MM271_01305	COG1178	ABC-type Fe3 transport system permease component
MM271_01320	COG0705	Rhomboid family
MM271_01325	COG0736	holo-[acyl-carrier-protein] synthase activity
MM271_01330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MM271_01335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MM271_01340	COG0864	Transcriptional regulator
MM271_01345	COG2337	Toxic component of a toxin-antitoxin (TA) module
MM271_01350	COG1366	Belongs to the anti-sigma-factor antagonist family
MM271_01355	COG1366	Belongs to the anti-sigma-factor antagonist family
MM271_01360	COG2172	sigma factor antagonist activity
MM271_01365	COG2208	phosphoserine phosphatase activity
MM271_01370	COG1366	Belongs to the anti-sigma-factor antagonist family
MM271_01375	COG2172	sigma factor antagonist activity
MM271_01380	COG1191	sigma factor activity
MM271_01390	COG2183	response to ionizing radiation
MM271_01400	COG3091	SprT-like family
MM271_01475	COG0626	cystathionine gamma-synthase activity
MM271_01485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MM271_01490	COG0802	atpase or kinase
MM271_01495	COG1214	PFAM Peptidase M22, glycoprotease
MM271_01500	COG0456	acetyltransferase
MM271_01515	COG0488	(ABC) transporter
MM271_01520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MM271_01525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MM271_01530	COG0805	protein transport
MM271_01535	COG2814	Major facilitator Superfamily
MM271_01545	COG2203	Gaf domain
MM271_01545	COG4585	Histidine kinase
MM271_01550	COG2197	response regulator
MM271_01565	COG1266	CAAX protease self-immunity
MM271_01575	COG0459	protein refolding
MM271_01580	COG0582	viral genome integration into host DNA
MM271_01590	COG0582	viral genome integration into host DNA
MM271_01615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM271_01660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MM271_01680	COG1131	(ABC) transporter
MM271_01735	COG0647	UMP catabolic process
MM271_01740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MM271_01750	COG1175	transmembrane transport
MM271_01770	COG1266	CAAX protease self-immunity
MM271_01775	COG1609	Transcriptional regulator
MM271_01780	COG1175	transmembrane transport
MM271_01785	COG0395	ABC-type sugar transport system, permease component
MM271_01790	COG5578	integral membrane protein
MM271_01795	COG1653	transport
MM271_01800	COG3534	alpha-L-arabinofuranosidase
MM271_01810	COG0747	negative chemotaxis
MM271_01815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MM271_01830	COG0716	FMN binding
MM271_01845	COG0534	Mate efflux family protein
MM271_01875	COG4509	Sortase family
MM271_01880	COG1607	acyl-coa hydrolase
MM271_01885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MM271_01905	COG3279	Response regulator of the LytR AlgR family
MM271_01915	COG0745	RESPONSE REGULATOR receiver
MM271_01915	COG2972	Histidine kinase
MM271_01920	COG3842	ATPase activity
MM271_01930	COG0395	ABC-type sugar transport system, permease component
MM271_01950	COG1404	Belongs to the peptidase S8 family
MM271_01955	COG0501	Belongs to the peptidase M48B family
MM271_01965	COG0714	Associated with various cellular activities
MM271_01970	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MM271_01975	COG1305	Transglutaminase-like
MM271_01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MM271_01980	COG0519	Catalyzes the synthesis of GMP from XMP
MM271_01985	COG2252	PERMEase
MM271_02030	COG3424	synthase
MM271_02035	COG1755	Isoprenylcysteine carboxyl methyltransferase
MM271_02040	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MM271_02050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MM271_02055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MM271_02060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MM271_02070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MM271_02075	COG0047	phosphoribosylformylglycinamidine synthase activity
MM271_02080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MM271_02085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MM271_02090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MM271_02095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MM271_02100	COG0138	bifunctional purine biosynthesis protein purh
MM271_02105	COG0151	Belongs to the GarS family
MM271_02115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MM271_02120	COG1470	cell adhesion involved in biofilm formation
MM271_02125	COG4496	protein, YerC YecD
MM271_02145	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MM271_02150	COG0210	DNA helicase
MM271_02155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MM271_02160	COG4851	CamS sex pheromone cAM373 precursor
MM271_02165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MM271_02170	COG0154	amidase activity
MM271_02175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MM271_02180	COG0346	lactoylglutathione lyase activity
MM271_02185	COG1597	lipid kinase activity
MM271_02190	COG1595	DNA-templated transcription, initiation
MM271_02215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MM271_02220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM271_02225	COG2909	trisaccharide binding
MM271_02245	COG4085	toxin activity
MM271_02245	COG1525	nuclease
MM271_02245	COG0737	Belongs to the 5'-nucleotidase family
MM271_02285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MM271_02295	COG3693	PFAM glycoside hydrolase, family 10
MM271_02300	COG3507	Belongs to the glycosyl hydrolase 43 family
MM271_02315	COG1175	transmembrane transport
MM271_02320	COG0395	ABC-type sugar transport system, permease component
MM271_02325	COG5578	integral membrane protein
MM271_02330	COG1070	Carbohydrate kinase
MM271_02340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MM271_02345	COG1215	transferase activity, transferring glycosyl groups
MM271_02355	COG2272	Belongs to the type-B carboxylesterase lipase family
MM271_02365	COG0789	Transcriptional regulator
MM271_02370	COG3226	Transcriptional regulator
MM271_02460	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MM271_02465	COG0596	Alpha beta hydrolase
MM271_02495	COG1309	transcriptional regulator
MM271_02505	COG2309	aminopeptidase activity
MM271_02510	COG1595	DNA-templated transcription, initiation
MM271_02530	COG2738	Putative neutral zinc metallopeptidase
MM271_02540	COG3706	GGDEF domain
MM271_02550	COG0596	Alpha beta hydrolase
MM271_02555	COG2208	phosphoserine phosphatase activity
MM271_02565	COG2264	protein methyltransferase activity
MM271_02570	COG1271	oxidase subunit
MM271_02575	COG1294	oxidase, subunit
MM271_02580	COG4988	ABC transporter
MM271_02585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MM271_02590	COG1988	membrane-bound metal-dependent
MM271_02595	COG2267	carboxylic ester hydrolase activity
MM271_02610	COG5386	Cell surface protein
MM271_02615	COG5386	Cell surface protein
MM271_02630	COG1120	ATPase activity
MM271_02635	COG4509	Sortase family
MM271_02645	COG2329	Antibiotic biosynthesis monooxygenase
MM271_02655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_02665	COG0584	glycerophosphoryl diester phosphodiesterase
MM271_02670	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM271_02680	COG3437	response regulator, receiver
MM271_02685	COG1846	Transcriptional regulator
MM271_02700	COG1115	amino acid carrier protein
MM271_02705	COG1132	(ABC) transporter
MM271_02710	COG1132	(ABC) transporter
MM271_02715	COG2244	polysaccharide biosynthetic process
MM271_02720	COG0667	Aldo Keto reductase
MM271_02735	COG0386	Belongs to the glutathione peroxidase family
MM271_02740	COG1846	Transcriptional regulator
MM271_02750	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MM271_02755	COG1074	ATP-dependent DNA helicase activity
MM271_02760	COG0420	3'-5' exonuclease activity
MM271_02765	COG0419	ATPase involved in DNA repair
MM271_02775	COG0604	alcohol dehydrogenase
MM271_02780	COG0586	Pfam SNARE associated Golgi protein
MM271_02790	COG0534	Mate efflux family protein
MM271_02795	COG0328	RNA-DNA hybrid ribonuclease activity
MM271_02795	COG3341	Caulimovirus viroplasmin
MM271_02800	COG1309	transcriptional regulator
MM271_02810	COG0596	Alpha beta hydrolase
MM271_02825	COG1126	abc transporter atp-binding protein
MM271_02830	COG0765	amino acid transport
MM271_02835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM271_02845	COG1263	PTS System
MM271_02845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MM271_02850	COG0366	Alpha amylase catalytic
MM271_02855	COG2188	Transcriptional regulator
MM271_02865	COG0028	Belongs to the TPP enzyme family
MM271_02880	COG0714	Associated with various cellular activities
MM271_02900	COG1294	oxidase, subunit
MM271_02905	COG1271	oxidase subunit
MM271_02930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_02945	COG0477	Major facilitator Superfamily
MM271_03070	COG0534	Mate efflux family protein
MM271_03075	COG2364	Membrane
MM271_03085	COG0154	amidase activity
MM271_03115	COG1595	DNA-templated transcription, initiation
MM271_03130	COG0494	nUDIX hydrolase
MM271_03135	COG1335	isochorismatase
MM271_03145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MM271_03150	COG1794	racemase activity, acting on amino acids and derivatives
MM271_03155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MM271_03185	COG1388	LysM domain
MM271_03195	COG4533	DNA binding
MM271_03210	COG0840	transmembrane signaling receptor activity
MM271_03230	COG0561	phosphatase activity
MM271_03235	COG1136	(ABC) transporter
MM271_03240	COG0577	efflux transmembrane transporter activity
MM271_03255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM271_03260	COG3832	glyoxalase III activity
MM271_03270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MM271_03285	COG0535	radical SAM domain protein
MM271_03295	COG0406	alpha-ribazole phosphatase activity
MM271_03315	COG1595	DNA-templated transcription, initiation
MM271_03325	COG0662	Cupin 2, conserved barrel domain protein
MM271_03330	COG0488	(ABC) transporter
MM271_03340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MM271_03365	COG0840	transmembrane signaling receptor activity
MM271_03385	COG2409	Drug exporters of the RND superfamily
MM271_03410	COG3655	Transcriptional regulator
MM271_03415	COG0154	amidase activity
MM271_03440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MM271_03455	COG0747	negative chemotaxis
MM271_03460	COG0601	transmembrane transport
MM271_03465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_03470	COG0444	Belongs to the ABC transporter superfamily
MM271_03475	COG1124	(ABC) transporter
MM271_03495	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_03500	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_03515	COG1959	2 iron, 2 sulfur cluster binding
MM271_03530	COG1595	DNA-templated transcription, initiation
MM271_03565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MM271_03565	COG1263	PTS System
MM271_03585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM271_03590	COG1131	(ABC) transporter
MM271_03630	COG1595	DNA-templated transcription, initiation
MM271_03660	COG1131	(ABC) transporter
MM271_03680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MM271_03695	COG1181	Belongs to the D-alanine--D-alanine ligase family
MM271_03700	COG1876	peptidase activity
MM271_03720	COG0747	negative chemotaxis
MM271_03725	COG0601	transmembrane transport
MM271_03730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_03735	COG0444	Belongs to the ABC transporter superfamily
MM271_03740	COG4608	Belongs to the ABC transporter superfamily
MM271_03785	COG0741	lytic transglycosylase activity
MM271_03785	COG0791	NLP P60 protein
MM271_03820	COG0443	Heat shock 70 kDa protein
MM271_03840	COG0492	ferredoxin-NADP+ reductase activity
MM271_03845	COG2226	methyltransferase
MM271_03850	COG2211	Major facilitator Superfamily
MM271_03865	COG0456	acetyltransferase
MM271_03880	COG2197	response regulator
MM271_03885	COG4585	Histidine kinase
MM271_03895	COG1278	Cold shock
MM271_03900	COG4895	conserved protein (DUF2196)
MM271_03905	COG3708	Transcriptional regulator
MM271_03905	COG2207	Transcriptional regulator
MM271_03930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM271_03935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MM271_03945	COG4682	membrane
MM271_03950	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MM271_04000	COG5578	integral membrane protein
MM271_04005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MM271_04010	COG0483	inositol monophosphate 1-phosphatase activity
MM271_04015	COG2188	Transcriptional regulator
MM271_04020	COG4209	transmembrane transport
MM271_04025	COG0395	ABC-type sugar transport system, permease component
MM271_04030	COG1653	transport
MM271_04065	COG2124	cytochrome p450
MM271_04080	COG0697	spore germination
MM271_04095	COG0747	negative chemotaxis
MM271_04105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_04110	COG0444	Belongs to the ABC transporter superfamily
MM271_04115	COG4608	Belongs to the ABC transporter superfamily
MM271_04125	COG2885	chlorophyll binding
MM271_04130	COG1842	Phage shock protein A
MM271_04135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MM271_04145	COG4260	virion core protein, lumpy skin disease virus
MM271_04160	COG0681	Belongs to the peptidase S26 family
MM271_04185	COG3711	transcriptional antiterminator
MM271_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MM271_04190	COG1263	PTS System
MM271_04195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MM271_04200	COG1621	beta-fructofuranosidase activity
MM271_04205	COG0406	alpha-ribazole phosphatase activity
MM271_04220	COG0494	nUDIX hydrolase
MM271_04225	COG0840	transmembrane signaling receptor activity
MM271_04230	COG4213	ABC transporter substrate-binding protein
MM271_04235	COG0840	transmembrane signaling receptor activity
MM271_04240	COG4585	Histidine kinase
MM271_04245	COG0483	inositol monophosphate 1-phosphatase activity
MM271_04280	COG2814	Major facilitator Superfamily
MM271_04300	COG3239	Fatty acid desaturase
MM271_04305	COG4585	Histidine kinase
MM271_04310	COG2197	response regulator
MM271_04315	COG1595	DNA-templated transcription, initiation
MM271_04325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MM271_04335	COG0561	phosphatase activity
MM271_04340	COG1268	BioY protein
MM271_04350	COG0765	amino acid transport
MM271_04355	COG1126	abc transporter atp-binding protein
MM271_04360	COG3639	organic phosphonate transmembrane transporter activity
MM271_04365	COG3639	organic phosphonate transmembrane transporter activity
MM271_04370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MM271_04380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MM271_04385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MM271_04390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MM271_04390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MM271_04405	COG1522	sequence-specific DNA binding
MM271_04445	COG1131	(ABC) transporter
MM271_04470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MM271_04475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MM271_04480	COG3383	formate dehydrogenase (NAD+) activity
MM271_04485	COG0366	Alpha amylase catalytic
MM271_04505	COG1609	Transcriptional regulator
MM271_04520	COG2223	nitrite transmembrane transporter activity
MM271_04545	COG0840	transmembrane signaling receptor activity
MM271_04550	COG1595	DNA-templated transcription, initiation
MM271_04575	COG1396	sequence-specific DNA binding
MM271_04575	COG1917	Cupin 2, conserved barrel domain protein
MM271_04580	COG1917	Cupin 2, conserved barrel domain protein
MM271_04585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MM271_04590	COG0456	acetyltransferase
MM271_04610	COG1090	epimerase
MM271_04615	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_04625	COG1349	DNA-binding transcription factor activity
MM271_04630	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_04635	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MM271_04640	COG0800	Aldolase
MM271_04645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MM271_04650	COG0673	inositol 2-dehydrogenase activity
MM271_04655	COG1653	transport
MM271_04660	COG1175	transmembrane transport
MM271_04665	COG0395	ABC-type sugar transport system, permease component
MM271_04670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MM271_04680	COG5578	integral membrane protein
MM271_04685	COG2972	Histidine kinase
MM271_04690	COG4753	response regulator
MM271_04690	COG2207	Transcriptional regulator
MM271_04710	COG1940	carbohydrate kinase activity
MM271_04715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MM271_04720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MM271_04725	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MM271_04730	COG0523	cobalamin synthesis protein
MM271_04740	COG3347	Dehydrogenase
MM271_04740	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_04745	COG1070	Carbohydrate kinase
MM271_04750	COG4806	L-rhamnose isomerase
MM271_04755	COG1349	DNA-binding transcription factor activity
MM271_04760	COG0247	lactate metabolic process
MM271_04765	COG1139	Iron-sulfur cluster binding protein
MM271_04770	COG1556	Lactate utilization protein
MM271_04790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MM271_04810	COG0572	uridine kinase
MM271_04830	COG0110	maltose O-acetyltransferase activity
MM271_04835	COG2137	regulation of response to DNA damage stimulus
MM271_04840	COG1620	l-lactate permease
MM271_04860	COG1988	membrane-bound metal-dependent
MM271_04870	COG1194	a g-specific adenine glycosylase
MM271_04875	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_04880	COG1522	sequence-specific DNA binding
MM271_04885	COG0024	Methionine aminopeptidase
MM271_04895	COG2059	Chromate
MM271_04900	COG2059	Chromate
MM271_04935	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_04950	COG3557	Belongs to the UPF0374 family
MM271_04955	COG1132	(ABC) transporter
MM271_04960	COG0772	Belongs to the SEDS family
MM271_04975	COG3340	Belongs to the peptidase S51 family
MM271_05010	COG4129	membrane
MM271_05020	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_05035	COG3547	Transposase (IS116 IS110 IS902 family)
MM271_05050	COG0745	RESPONSE REGULATOR receiver
MM271_05055	COG5002	protein histidine kinase activity
MM271_05075	COG0534	Mate efflux family protein
MM271_05095	COG2318	DinB family
MM271_05115	COG2323	membrane
MM271_05120	COG0067	glutamate synthase
MM271_05120	COG0070	glutamate synthase
MM271_05120	COG0069	glutamate synthase activity
MM271_05125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MM271_05130	COG4555	ABC transporter
MM271_05145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MM271_05165	COG0204	Acyl-transferase
MM271_05175	COG0789	Transcriptional regulator
MM271_05250	COG1733	regulation of RNA biosynthetic process
MM271_05265	COG1309	transcriptional regulator
MM271_05295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MM271_05300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MM271_05305	COG3870	Protein conserved in bacteria
MM271_05310	COG0735	belongs to the Fur family
MM271_05410	COG3344	reverse transcriptase
MM271_05430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM271_05500	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_05520	COG0673	inositol 2-dehydrogenase activity
MM271_05525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MM271_05585	COG1074	ATP-dependent DNA helicase activity
MM271_05645	COG0270	DNA (cytosine-5-)-methyltransferase activity
MM271_05690	COG1476	TRANSCRIPTIONal
MM271_05700	COG1131	(ABC) transporter
MM271_05720	COG3842	ATPase activity
MM271_05725	COG1175	transmembrane transport
MM271_05735	COG1653	transport
MM271_05740	COG1609	Transcriptional regulator
MM271_05745	COG1653	transport
MM271_05750	COG1175	transmembrane transport
MM271_05755	COG0395	ABC-type sugar transport system, permease component
MM271_05760	COG1486	melibiose metabolic process
MM271_05770	COG1309	transcriptional regulator
MM271_05810	COG1595	DNA-templated transcription, initiation
MM271_05825	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MM271_05835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MM271_05845	COG2972	Histidine kinase
MM271_05850	COG2204	response regulator
MM271_05855	COG4213	ABC transporter substrate-binding protein
MM271_05865	COG0789	Transcriptional regulator
MM271_05865	COG4978	Transcriptional regulator
MM271_05880	COG2207	Transcriptional regulator
MM271_05920	COG2378	regulation of single-species biofilm formation
MM271_05940	COG4213	ABC transporter substrate-binding protein
MM271_05950	COG4214	carbohydrate transport
MM271_05965	COG1329	Transcriptional regulator
MM271_05970	COG0697	spore germination
MM271_05985	COG3173	Aminoglycoside phosphotransferase
MM271_06055	COG0745	RESPONSE REGULATOR receiver
MM271_06060	COG2205	protein histidine kinase activity
MM271_06065	COG1136	(ABC) transporter
MM271_06070	COG0577	efflux transmembrane transporter activity
MM271_06100	COG1609	Transcriptional regulator
MM271_06105	COG0561	phosphatase activity
MM271_06130	COG2226	methyltransferase
MM271_06135	COG0583	DNA-binding transcription factor activity
MM271_06175	COG0537	adenosine 5'-monophosphoramidase activity
MM271_06210	COG2226	methyltransferase
MM271_06250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MM271_06250	COG2755	lipolytic protein G-D-S-L family
MM271_06265	COG3290	protein histidine kinase activity
MM271_06270	COG4565	transcriptional regulatory protein
MM271_06275	COG2329	Antibiotic biosynthesis monooxygenase
MM271_06305	COG1595	DNA-templated transcription, initiation
MM271_06325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM271_06335	COG2076	Multidrug Resistance protein
MM271_06340	COG2076	Multidrug Resistance protein
MM271_06365	COG2226	methyltransferase
MM271_06395	COG0456	acetyltransferase
MM271_06440	COG0406	alpha-ribazole phosphatase activity
MM271_06455	COG1309	transcriptional regulator
MM271_06470	COG2207	Transcriptional regulator
MM271_06475	COG5578	integral membrane protein
MM271_06480	COG1653	transport
MM271_06485	COG4209	transmembrane transport
MM271_06490	COG0395	ABC-type sugar transport system, permease component
MM271_06495	COG0673	inositol 2-dehydrogenase activity
MM271_06510	COG0444	Belongs to the ABC transporter superfamily
MM271_06515	COG4608	Belongs to the ABC transporter superfamily
MM271_06520	COG0747	negative chemotaxis
MM271_06525	COG0601	transmembrane transport
MM271_06530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_06540	COG4585	Histidine kinase
MM271_06545	COG2197	response regulator
MM271_06550	COG1131	(ABC) transporter
MM271_06570	COG1132	(ABC) transporter
MM271_06585	COG3300	MHYT domain
MM271_06585	COG5001	Diguanylate cyclase
MM271_06605	COG3739	integral membrane protein
MM271_06630	COG0789	Transcriptional regulator
MM271_06630	COG4978	Transcriptional regulator
MM271_06635	COG0628	permease
MM271_06645	COG2207	Transcriptional regulator
MM271_06645	COG4753	response regulator
MM271_06650	COG2972	Histidine kinase
MM271_06670	COG3250	beta-galactosidase activity
MM271_06680	COG0628	permease
MM271_06690	COG2135	peptidase activity
MM271_06700	COG2188	Transcriptional regulator
MM271_06705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MM271_06730	COG0295	cytidine deaminase activity
MM271_06735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MM271_06745	COG1511	domain protein
MM271_06750	COG0697	spore germination
MM271_06755	COG1802	Transcriptional regulator
MM271_06770	COG2124	cytochrome p450
MM271_06775	COG2508	Transcriptional regulator
MM271_06785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MM271_06790	COG1012	belongs to the aldehyde dehydrogenase family
MM271_06795	COG0506	proline dehydrogenase activity
MM271_06805	COG1404	Belongs to the peptidase S8 family
MM271_06830	COG1309	transcriptional regulator
MM271_06835	COG1131	(ABC) transporter
MM271_06850	COG2202	Pas domain
MM271_06850	COG1366	Belongs to the anti-sigma-factor antagonist family
MM271_06855	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MM271_06860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MM271_06865	COG0156	8-amino-7-oxononanoate synthase activity
MM271_06875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MM271_06880	COG2124	cytochrome p450
MM271_06890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM271_06895	COG0697	spore germination
MM271_06930	COG2318	DinB family
MM271_06950	COG0783	Belongs to the Dps family
MM271_06955	COG3382	B3 4 domain protein
MM271_06965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MM271_06990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MM271_06995	COG2766	serine protein kinase
MM271_07005	COG2718	Belongs to the UPF0229 family
MM271_07015	COG0737	Belongs to the 5'-nucleotidase family
MM271_07020	COG1523	belongs to the glycosyl hydrolase 13 family
MM271_07025	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MM271_07030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MM271_07035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MM271_07045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MM271_07050	COG0737	Belongs to the 5'-nucleotidase family
MM271_07055	COG1363	Peptidase, m42
MM271_07065	COG1131	(ABC) transporter
MM271_07070	COG1725	Transcriptional regulator
MM271_07075	COG3852	Histidine kinase
MM271_07080	COG0671	phosphoesterase, PA-phosphatase related
MM271_07090	COG0366	Alpha amylase catalytic
MM271_07100	COG0840	transmembrane signaling receptor activity
MM271_07110	COG1175	transmembrane transport
MM271_07115	COG3833	ABC-type maltose transport systems, permease component
MM271_07125	COG0366	Alpha amylase catalytic
MM271_07135	COG1959	2 iron, 2 sulfur cluster binding
MM271_07140	COG1017	nitric oxide dioxygenase activity
MM271_07140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MM271_07150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MM271_07155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MM271_07160	COG2508	Transcriptional regulator
MM271_07160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MM271_07165	COG0686	Belongs to the AlaDH PNT family
MM271_07175	COG0584	glycerophosphoryl diester phosphodiesterase
MM271_07185	COG2201	protein-glutamate methylesterase activity
MM271_07190	COG0058	SHG alpha-glucan phosphorylase activity
MM271_07195	COG0297	glycogen (starch) synthase activity
MM271_07200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MM271_07205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MM271_07210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MM271_07220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM271_07220	COG3153	acetyltransferase
MM271_07225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MM271_07235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM271_07245	COG0640	Transcriptional regulator
MM271_07250	COG0346	lactoylglutathione lyase activity
MM271_07260	COG5578	integral membrane protein
MM271_07270	COG0613	PHP domain protein
MM271_07280	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
MM271_07290	COG3627	carbon phosphorus lyase activity
MM271_07295	COG4107	phosphonate C-P lyase system protein PhnK
MM271_07300	COG3454	Phosphonate metabolism
MM271_07305	COG4778	phosphonate C-P lyase system protein PhnL
MM271_07310	COG0745	RESPONSE REGULATOR receiver
MM271_07315	COG2188	Transcriptional regulator
MM271_07320	COG3290	protein histidine kinase activity
MM271_07320	COG3829	transcription factor binding
MM271_07325	COG1012	belongs to the aldehyde dehydrogenase family
MM271_07330	COG1454	alcohol dehydrogenase
MM271_07345	COG2719	SpoVR family
MM271_07355	COG0768	penicillin binding
MM271_07360	COG2223	nitrite transmembrane transporter activity
MM271_07365	COG0667	Aldo Keto reductase
MM271_07375	COG1309	transcriptional regulator
MM271_07380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MM271_07385	COG3944	biosynthesis protein
MM271_07390	COG0489	protein tyrosine kinase activity
MM271_07395	COG1086	Polysaccharide biosynthesis protein
MM271_07400	COG0438	transferase activity, transferring glycosyl groups
MM271_07405	COG1216	Glycosyl transferase, family 2
MM271_07410	COG0438	transferase activity, transferring glycosyl groups
MM271_07430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MM271_07440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MM271_07455	COG1216	Glycosyl transferase, family 2
MM271_07465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MM271_07510	COG1132	(ABC) transporter
MM271_07515	COG1408	metallophosphoesterase
MM271_07520	COG0018	arginyl-trna synthetase
MM271_07525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM271_07530	COG1879	ABC-type sugar transport system periplasmic component
MM271_07535	COG2972	Histidine kinase
MM271_07540	COG4753	response regulator
MM271_07540	COG2207	Transcriptional regulator
MM271_07550	COG1175	transmembrane transport
MM271_07555	COG0395	ABC-type sugar transport system, permease component
MM271_07560	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_07565	COG3852	Histidine kinase
MM271_07570	COG0733	neurotransmitter:sodium symporter activity
MM271_07575	COG0702	epimerase
MM271_07590	COG3842	ATPase activity
MM271_07595	COG2508	Transcriptional regulator
MM271_07605	COG0450	alkyl hydroperoxide reductase
MM271_07625	COG0189	ligase activity
MM271_07630	COG0189	ligase activity
MM271_07640	COG4399	Belongs to the UPF0754 family
MM271_07645	COG3679	Belongs to the UPF0342 family
MM271_07650	COG0561	phosphatase activity
MM271_07665	COG0706	membrane insertase activity
MM271_07680	COG0420	3'-5' exonuclease activity
MM271_07685	COG4717	serine-type aminopeptidase activity
MM271_07690	COG0745	RESPONSE REGULATOR receiver
MM271_07695	COG2770	Histidine kinase
MM271_07695	COG2205	protein histidine kinase activity
MM271_07700	COG3481	metal-dependent phosphohydrolase, HD sub domain
MM271_07720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MM271_07750	COG1846	Transcriptional regulator
MM271_07765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MM271_07770	COG0537	adenosine 5'-monophosphoramidase activity
MM271_07775	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_07780	COG1131	(ABC) transporter
MM271_07785	COG4473	ABC transporter
MM271_07795	COG2814	Major facilitator Superfamily
MM271_07805	COG3858	chitin binding
MM271_07810	COG2022	thiamine diphosphate biosynthetic process
MM271_07815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MM271_07820	COG1473	amidohydrolase
MM271_07825	COG0785	Cytochrome C biogenesis protein
MM271_07835	COG1842	Phage shock protein A
MM271_07845	COG4758	membrane
MM271_07850	COG4585	Histidine kinase
MM271_07855	COG2197	response regulator
MM271_07865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MM271_07870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MM271_07875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MM271_07880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MM271_07890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM271_07905	COG3290	protein histidine kinase activity
MM271_07910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MM271_07915	COG4492	Belongs to the UPF0735 family
MM271_07920	COG0077	Prephenate dehydratase
MM271_07925	COG1827	regulation of RNA biosynthetic process
MM271_07930	COG1104	cysteine desulfurase activity
MM271_07935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MM271_07940	COG0157	Belongs to the NadC ModD family
MM271_07945	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MM271_07950	COG1388	LysM domain
MM271_07965	COG0632	four-way junction helicase activity
MM271_07970	COG2255	four-way junction helicase activity
MM271_07980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MM271_07985	COG0343	queuine tRNA-ribosyltransferase activity
MM271_07990	COG1862	Preprotein translocase
MM271_08000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MM271_08005	COG2323	membrane
MM271_08015	COG2244	polysaccharide biosynthetic process
MM271_08030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM271_08030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM271_08035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM271_08035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM271_08040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MM271_08045	COG5416	Lipopolysaccharide assembly protein A domain
MM271_08050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MM271_08050	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MM271_08055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MM271_08060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MM271_08065	COG1490	D-aminoacyl-tRNA deacylase activity
MM271_08070	COG2239	Acts as a magnesium transporter
MM271_08075	COG1285	pathogenesis
MM271_08080	COG2239	Acts as a magnesium transporter
MM271_08090	COG0124	histidyl-tRNA synthetase
MM271_08095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MM271_08115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MM271_08125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MM271_08130	COG2364	Membrane
MM271_08135	COG1959	2 iron, 2 sulfur cluster binding
MM271_08140	COG1104	cysteine desulfurase activity
MM271_08145	COG0482	sulfurtransferase activity
MM271_08155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MM271_08175	COG0628	permease
MM271_08180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MM271_08185	COG4472	Bacterial protein of unknown function (DUF965)
MM271_08190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MM271_08195	COG3906	Belongs to the UPF0473 family
MM271_08200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MM271_08205	COG4122	O-methyltransferase activity
MM271_08210	COG0826	peptidase U32
MM271_08215	COG0826	peptidase U32
MM271_08220	COG0572	uridine kinase
MM271_08225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MM271_08230	COG1063	alcohol dehydrogenase
MM271_08240	COG1725	Transcriptional regulator
MM271_08245	COG1131	(ABC) transporter
MM271_08265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MM271_08275	COG0494	nUDIX hydrolase
MM271_08280	COG1506	peptidase
MM271_08280	COG4946	Tricorn protease homolog
MM271_08280	COG0823	Involved in the tonB-independent uptake of proteins
MM271_08285	COG1522	sequence-specific DNA binding
MM271_08290	COG2197	response regulator
MM271_08295	COG4585	Histidine kinase
MM271_08305	COG4106	trans-aconitate 2-methyltransferase activity
MM271_08310	COG1846	Transcriptional regulator
MM271_08325	COG1396	sequence-specific DNA binding
MM271_08330	COG1396	sequence-specific DNA binding
MM271_08360	COG0783	Belongs to the Dps family
MM271_08365	COG0488	(ABC) transporter
MM271_08375	COG1131	(ABC) transporter
MM271_08380	COG2188	Transcriptional regulator
MM271_08385	COG0776	regulation of translation
MM271_08390	COG0688	phosphatidylethanolamine metabolic process
MM271_08395	COG1320	monovalent cation:proton antiporter activity
MM271_08400	COG2212	antiporter activity
MM271_08405	COG1863	multisubunit Na H antiporter MnhE subunit
MM271_08410	COG0651	ATP synthesis coupled electron transport
MM271_08415	COG1006	Multisubunit Na H antiporter MnhC subunit
MM271_08420	COG2111	Na H antiporter
MM271_08425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MM271_08425	COG2111	Na H antiporter
MM271_08440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MM271_08445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MM271_08450	COG1534	Rna-binding protein
MM271_08455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MM271_08460	COG1713	HD superfamily hydrolase involved in NAD metabolism
MM271_08465	COG0799	negative regulation of ribosome biogenesis
MM271_08470	COG2996	Protein conserved in bacteria
MM271_08475	COG2226	methyltransferase
MM271_08480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MM271_08490	COG1555	photosystem II stabilization
MM271_08490	COG1596	polysaccharide export
MM271_08500	COG2131	deaminase
MM271_08505	COG0658	competence protein
MM271_08505	COG2333	competence protein COMEC
MM271_08515	COG1466	dna polymerase III delta subunit
MM271_08520	COG0268	Binds directly to 16S ribosomal RNA
MM271_08525	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MM271_08530	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM271_08540	COG0481	GTPase activity
MM271_08545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MM271_08550	COG1420	regulation of RNA biosynthetic process
MM271_08555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MM271_08565	COG0484	heat shock protein binding
MM271_08570	COG2264	protein methyltransferase activity
MM271_08575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MM271_08580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM271_08585	COG3328	transposase activity
MM271_08590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MM271_08595	COG1283	sodium-dependent phosphate transmembrane transporter activity
MM271_08600	COG1960	acyl-CoA dehydrogenase activity
MM271_08605	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_08610	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_08615	COG0183	Belongs to the thiolase family
MM271_08620	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_08625	COG1309	transcriptional regulator
MM271_08630	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM271_08635	COG1024	Enoyl-CoA hydratase
MM271_08645	COG2045	Belongs to the ComB family
MM271_08650	COG1960	acyl-CoA dehydrogenase activity
MM271_08655	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_08690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MM271_08695	COG1610	YqeY-like protein
MM271_08700	COG1030	water channel activity
MM271_08725	COG1702	phosphate starvation-inducible protein PhoH
MM271_08730	COG1480	7TM receptor with intracellular HD hydrolase
MM271_08740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MM271_08750	COG0295	cytidine deaminase activity
MM271_08755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MM271_08765	COG1381	Involved in DNA repair and RecF pathway recombination
MM271_08770	COG0752	glycyl-tRNA synthetase alpha subunit
MM271_08775	COG0751	glycine-tRNA ligase activity
MM271_08780	COG0517	IMP dehydrogenase activity
MM271_08785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MM271_08790	COG1671	Belongs to the UPF0178 family
MM271_08795	COG0358	DNA primase activity
MM271_08800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MM271_08815	COG2384	SAM-dependent methyltransferase
MM271_08820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MM271_08825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MM271_08835	COG0513	Belongs to the DEAD box helicase family
MM271_08840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MM271_08850	COG3852	Histidine kinase
MM271_08855	COG1121	(ABC) transporter
MM271_08860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MM271_08870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MM271_08880	COG1121	(ABC) transporter
MM271_08885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MM271_08890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MM271_08895	COG0735	belongs to the Fur family
MM271_08900	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MM271_08905	COG4709	membrane
MM271_08910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MM271_08920	COG2814	Major facilitator Superfamily
MM271_08925	COG4086	secreted protein
MM271_08935	COG5521	maltodextrose utilization protein MalA
MM271_08940	COG0704	Plays a role in the regulation of phosphate uptake
MM271_08970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MM271_08975	COG0477	Major facilitator Superfamily
MM271_08985	COG0768	penicillin binding
MM271_09010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MM271_09020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MM271_09030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MM271_09050	COG0705	Rhomboid family
MM271_09050	COG0457	Tetratricopeptide repeat
MM271_09060	COG1363	Peptidase, m42
MM271_09065	COG0697	spore germination
MM271_09080	COG4483	Protein conserved in bacteria
MM271_09085	COG1940	carbohydrate kinase activity
MM271_09090	COG1027	Aspartate ammonia-lyase
MM271_09100	COG0352	thiamine-phosphate diphosphorylase activity
MM271_09110	COG2022	thiamine diphosphate biosynthetic process
MM271_09115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MM271_09120	COG0351	phosphomethylpyrimidine kinase
MM271_09130	COG0011	TIGRFAM Protein of
MM271_09145	COG0681	Belongs to the peptidase S26 family
MM271_09150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM271_09160	COG2271	Major facilitator Superfamily
MM271_09185	COG0456	acetyltransferase
MM271_09205	COG3708	Transcriptional regulator
MM271_09205	COG2207	Transcriptional regulator
MM271_09230	COG0745	RESPONSE REGULATOR receiver
MM271_09235	COG5002	protein histidine kinase activity
MM271_09240	COG1136	(ABC) transporter
MM271_09245	COG0577	efflux transmembrane transporter activity
MM271_09250	COG2312	Erythromycin esterase
MM271_09265	COG0535	radical SAM domain protein
MM271_09275	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MM271_09310	COG1408	metallophosphoesterase
MM271_09335	COG0346	lactoylglutathione lyase activity
MM271_09365	COG0642	Histidine kinase
MM271_09370	COG1846	Transcriptional regulator
MM271_09375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MM271_09400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MM271_09425	COG0561	phosphatase activity
MM271_09450	COG1078	dGTPase activity
MM271_09465	COG0406	alpha-ribazole phosphatase activity
MM271_09480	COG0840	transmembrane signaling receptor activity
MM271_09495	COG3328	transposase activity
MM271_09505	COG1595	DNA-templated transcription, initiation
MM271_09515	COG1388	LysM domain
MM271_09515	COG1705	Flagellar rod assembly protein muramidase FlgJ
MM271_09530	COG0473	3-isopropylmalate dehydrogenase activity
MM271_09555	COG1522	sequence-specific DNA binding
MM271_09570	COG2816	NAD+ diphosphatase activity
MM271_09575	COG3328	transposase activity
MM271_09580	COG0789	Transcriptional regulator
MM271_09600	COG2226	methyltransferase
MM271_09615	COG0772	Belongs to the SEDS family
MM271_09645	COG1902	pentaerythritol trinitrate reductase activity
MM271_09650	COG0477	Major facilitator Superfamily
MM271_09655	COG1309	transcriptional regulator
MM271_09670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM271_09685	COG0583	DNA-binding transcription factor activity
MM271_09695	COG1720	tRNA m6t6A37 methyltransferase activity
MM271_09705	COG0129	dihydroxy-acid dehydratase activity
MM271_09715	COG1051	belongs to the nudix hydrolase family
MM271_09755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MM271_09760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MM271_09800	COG2816	NAD+ diphosphatase activity
MM271_09815	COG5646	InterPro IPR014922
MM271_09820	COG1131	(ABC) transporter
MM271_09835	COG0477	Major facilitator Superfamily
MM271_09850	COG0693	protein deglycase activity
MM271_09880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MM271_09885	COG1459	type II secretion system
MM271_09890	COG4537	Required for transformation and DNA binding
MM271_09940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_09955	COG5504	Zn-dependent protease
MM271_09975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MM271_09980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MM271_09985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MM271_09990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MM271_10000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MM271_10005	COG0095	Lipoate-protein ligase
MM271_10010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MM271_10020	COG0596	Alpha beta hydrolase
MM271_10030	COG1533	DNA photolyase activity
MM271_10035	COG1321	iron dependent repressor
MM271_10040	COG1752	Esterase of the alpha-beta hydrolase superfamily
MM271_10055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MM271_10060	COG0006	proline dipeptidase activity
MM271_10065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MM271_10075	COG3854	ATPases associated with a variety of cellular activities
MM271_10120	COG0511	ligase activity, forming carbon-carbon bonds
MM271_10125	COG0439	Biotin carboxylase
MM271_10130	COG1302	Protein conserved in bacteria
MM271_10135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MM271_10140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MM271_10145	COG1570	exodeoxyribonuclease VII activity
MM271_10150	COG1722	exodeoxyribonuclease VII activity
MM271_10165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MM271_10170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MM271_10175	COG1438	arginine binding
MM271_10180	COG0497	DNA recombination
MM271_10185	COG0750	zinc metalloprotease
MM271_10190	COG0745	RESPONSE REGULATOR receiver
MM271_10200	COG0561	phosphatase activity
MM271_10205	COG1132	(ABC) transporter
MM271_10210	COG1132	(ABC) transporter
MM271_10235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MM271_10245	COG0583	DNA-binding transcription factor activity
MM271_10255	COG3290	protein histidine kinase activity
MM271_10255	COG3829	transcription factor binding
MM271_10260	COG0280	phosphate acetyltransferase
MM271_10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MM271_10280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MM271_10285	COG0022	dehydrogenase e1 component
MM271_10290	COG0508	dehydrogenase complex catalyzes the overall conversion of
MM271_10325	COG4129	membrane
MM271_10330	COG1376	ErfK ybiS ycfS ynhG family protein
MM271_10340	COG0346	lactoylglutathione lyase activity
MM271_10345	COG2195	Cleaves the N-terminal amino acid of tripeptides
MM271_10360	COG2257	FlhB HrpN YscU SpaS Family
MM271_10380	COG1728	Protein conserved in bacteria
MM271_10395	COG1902	pentaerythritol trinitrate reductase activity
MM271_10400	COG0517	IMP dehydrogenase activity
MM271_10415	COG0175	sulfate reduction
MM271_10420	COG2046	Belongs to the sulfate adenylyltransferase family
MM271_10425	COG0306	phosphate transporter
MM271_10430	COG0529	Catalyzes the synthesis of activated sulfate
MM271_10435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM271_10455	COG2861	carbohydrate metabolic process
MM271_10460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM271_10465	COG0789	Transcriptional regulator
MM271_10470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MM271_10470	COG1587	Uroporphyrinogen-III synthase
MM271_10485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM271_10540	COG1797	cobyrinic acid a,c-diamide synthase activity
MM271_10545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MM271_10555	COG1120	ATPase activity
MM271_10565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MM271_10580	COG5522	Integral membrane protein (intg_mem_TP0381)
MM271_10585	COG1366	Belongs to the anti-sigma-factor antagonist family
MM271_10590	COG1595	DNA-templated transcription, initiation
MM271_10600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MM271_10605	COG0527	aspartate kinase activity
MM271_10625	COG1349	DNA-binding transcription factor activity
MM271_10635	COG0395	ABC-type sugar transport system, permease component
MM271_10655	COG2076	Multidrug Resistance protein
MM271_10670	COG3764	Sortase (surface protein transpeptidase)
MM271_10680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MM271_10695	COG0300	oxidoreductase activity
MM271_10715	COG3546	catalase activity
MM271_10720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM271_10735	COG0726	polysaccharide deacetylase
MM271_10740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MM271_10870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MM271_10875	COG0582	viral genome integration into host DNA
MM271_10900	COG5484	DNA packaging
MM271_10915	COG0740	serine-type endopeptidase activity
MM271_10985	COG4824	toxin secretion phage lysis holin
MM271_10990	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM271_11085	COG1562	ergosterol biosynthetic process
MM271_11100	COG1215	transferase activity, transferring glycosyl groups
MM271_11115	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_11130	COG0673	inositol 2-dehydrogenase activity
MM271_11135	COG3300	MHYT domain
MM271_11135	COG5001	Diguanylate cyclase
MM271_11145	COG0183	Belongs to the thiolase family
MM271_11150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM271_11160	COG0701	Predicted permease
MM271_11165	COG0523	cobalamin synthesis protein
MM271_11170	COG1968	undecaprenyl-diphosphatase activity
MM271_11175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_11190	COG0494	nUDIX hydrolase
MM271_11195	COG1379	DNA repair
MM271_11200	COG1300	Membrane
MM271_11205	COG0735	belongs to the Fur family
MM271_11215	COG4974	Belongs to the 'phage' integrase family
MM271_11220	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MM271_11230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MM271_11240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MM271_11250	COG3300	MHYT domain
MM271_11250	COG5001	Diguanylate cyclase
MM271_11260	COG0789	Transcriptional regulator
MM271_11270	COG1668	transmembrane transport
MM271_11275	COG4152	abc transporter atp-binding protein
MM271_11280	COG1131	(ABC) transporter
MM271_11285	COG1725	Transcriptional regulator
MM271_11310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MM271_11315	COG2514	catechol 2,3-dioxygenase activity
MM271_11320	COG0583	DNA-binding transcription factor activity
MM271_11325	COG0372	Belongs to the citrate synthase family
MM271_11350	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_11375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MM271_11405	COG2814	Major facilitator Superfamily
MM271_11410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_11425	COG0784	Response regulator, receiver
MM271_11425	COG2198	Histidine kinase
MM271_11425	COG5002	protein histidine kinase activity
MM271_11440	COG4191	Histidine kinase
MM271_11450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_11470	COG0714	Associated with various cellular activities
MM271_11490	COG2814	Major facilitator Superfamily
MM271_11510	COG4335	DNA alkylation repair
MM271_11520	COG0626	cystathionine gamma-synthase activity
MM271_11530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MM271_11535	COG0747	negative chemotaxis
MM271_11540	COG0601	transmembrane transport
MM271_11545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM271_11560	COG0534	Mate efflux family protein
MM271_11580	COG2323	membrane
MM271_11585	COG0217	transcriptional regulatory protein
MM271_11600	COG0803	Belongs to the bacterial solute-binding protein 9 family
MM271_11615	COG1131	(ABC) transporter
MM271_11685	COG1131	(ABC) transporter
MM271_11700	COG0714	Associated with various cellular activities
MM271_11740	COG1132	(ABC) transporter
MM271_11745	COG5577	PFAM Coat F domain
MM271_11770	COG0488	(ABC) transporter
MM271_11785	COG1132	(ABC) transporter
MM271_11825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_11830	COG1309	transcriptional regulator
MM271_11850	COG0784	Response regulator, receiver
MM271_11850	COG2205	protein histidine kinase activity
MM271_11855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MM271_11860	COG3852	Histidine kinase
MM271_11870	COG0658	competence protein
MM271_11870	COG2333	competence protein COMEC
MM271_11880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MM271_11885	COG4473	ABC transporter
MM271_11890	COG1131	(ABC) transporter
MM271_11895	COG2105	PFAM AIG2 family protein
MM271_11895	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MM271_11900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MM271_11905	COG0697	spore germination
MM271_11920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM271_11920	COG3153	acetyltransferase
MM271_11925	COG0456	acetyltransferase
MM271_11930	COG1164	Oligoendopeptidase f
MM271_11945	COG1741	Belongs to the pirin family
MM271_11970	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM271_11975	COG0346	lactoylglutathione lyase activity
MM271_11980	COG0400	carboxylic ester hydrolase activity
MM271_11990	COG1587	Uroporphyrinogen-III synthase
MM271_11995	COG3069	C4-dicarboxylate transmembrane transporter activity
MM271_12000	COG1278	Cold shock
MM271_12010	COG5001	Diguanylate cyclase
MM271_12010	COG3300	MHYT domain
MM271_12030	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MM271_12035	COG3973	AAA domain
MM271_12045	COG3180	Ammonia monooxygenase
MM271_12050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MM271_12050	COG0723	plastoquinol--plastocyanin reductase activity
MM271_12070	COG2153	protein acetylation
MM271_12100	COG2723	6-phospho-beta-galactosidase activity
MM271_12105	COG1070	Carbohydrate kinase
MM271_12110	COG0561	phosphatase activity
MM271_12115	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MM271_12125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM271_12130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MM271_12135	COG4191	Histidine kinase
MM271_12180	COG0010	Belongs to the arginase family
MM271_12185	COG1122	ATPase activity
MM271_12220	COG0310	cobalt ion transport
MM271_12245	COG0656	L-ascorbic acid biosynthetic process
MM271_12250	COG0702	epimerase
MM271_12255	COG2340	Cysteine-rich secretory protein family
MM271_12260	COG2839	Protein conserved in bacteria
MM271_12265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MM271_12270	COG2146	nitrite reductase [NAD(P)H] activity
MM271_12275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MM271_12285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MM271_12290	COG0673	inositol 2-dehydrogenase activity
MM271_12295	COG2318	DinB family
MM271_12300	COG1834	amidinotransferase
MM271_12315	COG0708	Exodeoxyribonuclease III
MM271_12320	COG3328	transposase activity
MM271_12335	COG0243	molybdopterin cofactor binding
MM271_12345	COG0346	lactoylglutathione lyase activity
MM271_12350	COG1280	lysine exporter protein (LysE YggA)
MM271_12355	COG1113	amino acid transport
MM271_12360	COG1607	acyl-coa hydrolase
MM271_12365	COG2223	nitrite transmembrane transporter activity
MM271_12370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM271_12375	COG2146	nitrite reductase [NAD(P)H] activity
MM271_12400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM271_12405	COG1757	Na H antiporter
MM271_12410	COG1132	(ABC) transporter
MM271_12415	COG1132	(ABC) transporter
MM271_12420	COG1966	Carbon starvation protein
MM271_12430	COG0003	Pfam Anion-transporting ATPase
MM271_12435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MM271_12445	COG0384	phenazine biosynthesis protein PhzF
MM271_12455	COG3706	GGDEF domain
MM271_12460	COG3706	GGDEF domain
MM271_12465	COG3706	GGDEF domain
MM271_12480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MM271_12485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MM271_12490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MM271_12495	COG0716	FMN binding
MM271_12505	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MM271_12515	COG0463	Glycosyl transferase, family 2
MM271_12520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MM271_12525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MM271_12530	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MM271_12540	COG2027	D-alanyl-D-alanine carboxypeptidase
MM271_12550	COG0659	secondary active sulfate transmembrane transporter activity
MM271_12565	COG0569	domain protein
MM271_12570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM271_12575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MM271_12585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MM271_12595	COG0745	RESPONSE REGULATOR receiver
MM271_12600	COG5002	protein histidine kinase activity
MM271_12600	COG3850	Histidine kinase
MM271_12605	COG3212	peptidase
MM271_12635	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM271_12640	COG1196	nuclear chromosome segregation
MM271_12640	COG0741	lytic transglycosylase activity
MM271_12640	COG0739	heme binding
MM271_12660	COG2755	lipolytic protein G-D-S-L family
MM271_12665	COG0300	oxidoreductase activity
MM271_12670	COG1012	belongs to the aldehyde dehydrogenase family
MM271_12675	COG0840	transmembrane signaling receptor activity
MM271_12680	COG0697	spore germination
MM271_12715	COG1979	alcohol dehydrogenase
MM271_12720	COG3706	GGDEF domain
MM271_12730	COG0523	cobalamin synthesis protein
MM271_12735	COG0822	iron-sulfur transferase activity
MM271_12775	COG1469	GTP cyclohydrolase I activity
MM271_12780	COG0523	cobalamin synthesis protein
MM271_12785	COG2226	methyltransferase
MM271_12870	COG0366	Alpha amylase catalytic
MM271_12880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MM271_12885	COG0187	DNA topoisomerase II activity
MM271_12890	COG1832	CoA-binding protein
MM271_12905	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MM271_12920	COG0116	Belongs to the methyltransferase superfamily
MM271_12930	COG0328	RNA-DNA hybrid ribonuclease activity
MM271_12935	COG3599	regulation of cell shape
MM271_12940	COG4474	Belongs to the UPF0398 family
MM271_12950	COG3359	exonuclease
MM271_12955	COG1205	dead DEAH box helicase
MM271_12955	COG1111	helicase
MM271_12960	COG2318	DinB family
MM271_12970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MM271_12975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MM271_12980	COG2885	chlorophyll binding
MM271_12985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MM271_12990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MM271_12995	COG0314	molybdopterin synthase activity
MM271_13000	COG0303	'Molybdopterin
MM271_13005	COG0303	'Molybdopterin
MM271_13010	COG0303	'Molybdopterin
MM271_13030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MM271_13060	COG4753	response regulator
MM271_13060	COG2207	Transcriptional regulator
MM271_13065	COG2972	Histidine kinase
MM271_13070	COG1376	ErfK ybiS ycfS ynhG family protein
MM271_13085	COG3852	Histidine kinase
MM271_13110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MM271_13115	COG0791	NLP P60 protein
MM271_13115	COG1388	LysM domain
MM271_13125	COG0577	efflux transmembrane transporter activity
MM271_13130	COG1136	(ABC) transporter
MM271_13135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MM271_13145	COG0583	DNA-binding transcription factor activity
MM271_13150	COG2855	membrane
MM271_13155	COG1960	acyl-CoA dehydrogenase activity
MM271_13160	COG2706	6-phosphogluconolactonase activity
MM271_13165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM271_13170	COG1278	Cold shock
MM271_13180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MM271_13210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM271_13220	COG0697	spore germination
MM271_13230	COG0840	transmembrane signaling receptor activity
MM271_13235	COG0346	lactoylglutathione lyase activity
MM271_13250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MM271_13280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MM271_13285	COG0697	spore germination
MM271_13295	COG1012	belongs to the aldehyde dehydrogenase family
MM271_13300	COG0460	homoserine dehydrogenase
MM271_13305	COG1473	amidohydrolase
MM271_13310	COG0626	cystathionine gamma-synthase activity
MM271_13315	COG0006	proline dipeptidase activity
MM271_13320	COG4733	cellulase activity
MM271_13320	COG5297	Belongs to the glycosyl hydrolase family 6
MM271_13460	COG0493	'glutamate synthase
MM271_13465	COG0067	glutamate synthase
MM271_13465	COG0069	glutamate synthase activity
MM271_13465	COG0070	glutamate synthase
MM271_13495	COG0194	GDP metabolic process
MM271_13505	COG3428	Bacterial PH domain
MM271_13510	COG3402	PFAM membrane-flanked domain
MM271_13520	COG1413	lyase activity
MM271_13530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_13540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_13545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MM271_13575	COG0693	protein deglycase activity
MM271_13590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_13600	COG0840	transmembrane signaling receptor activity
MM271_13605	COG0784	Response regulator, receiver
MM271_13605	COG0835	chemotaxis
MM271_13615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MM271_13625	COG2860	membrane
MM271_13640	COG0789	Transcriptional regulator
MM271_13650	COG3331	DNA recombination
MM271_13655	COG4499	WXG100 protein secretion system (Wss), protein YukC
MM271_13655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MM271_13660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MM271_13670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MM271_13675	COG3935	DnaD domain protein
MM271_13680	COG0017	Asparaginyl-tRNA synthetase
MM271_13685	COG0436	Aminotransferase
MM271_13705	COG0402	S-adenosylhomocysteine deaminase activity
MM271_13715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MM271_13715	COG1199	ATP-dependent helicase activity
MM271_13725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MM271_13730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MM271_13740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MM271_13740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MM271_13745	COG0617	tRNA 3'-terminal CCA addition
MM271_13750	COG0438	transferase activity, transferring glycosyl groups
MM271_13755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MM271_13760	COG1803	Methylglyoxal synthase
MM271_13765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MM271_13770	COG1694	Mazg nucleotide pyrophosphohydrolase
MM271_13775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_13780	COG2738	Putative neutral zinc metallopeptidase
MM271_13790	COG4347	Protein of unknown function (DUF1405)
MM271_13795	COG2010	Cytochrome c
MM271_13795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MM271_13800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MM271_13805	COG0723	plastoquinol--plastocyanin reductase activity
MM271_13815	COG5582	Belongs to the UPF0302 family
MM271_13820	COG0457	Tetratricopeptide repeat
MM271_13830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MM271_13835	COG0287	Prephenate dehydrogenase
MM271_13840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MM271_13845	COG0159	tryptophan synthase activity
MM271_13850	COG0133	tryptophan synthase activity
MM271_13855	COG0135	phosphoribosylanthranilate isomerase activity
MM271_13860	COG0134	indole-3-glycerol-phosphate synthase activity
MM271_13865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MM271_13875	COG4401	Chorismate mutase type I
MM271_13880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MM271_13885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MM271_13890	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MM271_13895	COG0105	UTP biosynthetic process
MM271_13900	COG0142	geranyltranstransferase activity
MM271_13905	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MM271_13910	COG0163	prenyltransferase activity
MM271_13920	COG2226	methyltransferase
MM271_13925	COG0142	geranyltranstransferase activity
MM271_13935	COG0302	gtp cyclohydrolase
MM271_13940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MM271_13960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MM271_13965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MM271_13970	COG1160	GTP binding
MM271_13985	COG1304	FMN binding
MM271_13990	COG0539	negative regulation of cytoplasmic translation
MM271_13995	COG0204	Acyl-transferase
MM271_14000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MM271_14005	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MM271_14010	COG2959	enzyme of heme biosynthesis
MM271_14015	COG3773	Cell wall hydrolase
MM271_14015	COG3409	Peptidoglycan-binding domain 1 protein
MM271_14025	COG0646	methionine synthase
MM271_14025	COG1410	methionine synthase
MM271_14030	COG0646	methionine synthase
MM271_14030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MM271_14035	COG0626	cystathionine gamma-synthase activity
MM271_14040	COG0626	cystathionine gamma-synthase activity
MM271_14050	COG2339	peptidase activity
MM271_14060	COG0492	ferredoxin-NADP+ reductase activity
MM271_14065	COG1181	Belongs to the D-alanine--D-alanine ligase family
MM271_14070	COG4862	establishment of competence for transformation
MM271_14075	COG0789	Transcriptional regulator
MM271_14080	COG1408	metallophosphoesterase
MM271_14090	COG1247	-acetyltransferase
MM271_14095	COG1984	allophanate hydrolase subunit 2
MM271_14100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MM271_14105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MM271_14110	COG2264	protein methyltransferase activity
MM271_14115	COG1510	regulation of RNA biosynthetic process
MM271_14140	COG2270	Major facilitator Superfamily
MM271_14145	COG1404	Belongs to the peptidase S8 family
MM271_14170	COG1266	CAAX protease self-immunity
MM271_14175	COG0514	ATP-dependent DNA helicase (RecQ)
MM271_14180	COG4955	Helix-turn-helix domain
MM271_14185	COG1141	Ferredoxin
MM271_14195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MM271_14215	COG2720	vancomycin resistance protein
MM271_14220	COG2096	Adenosyltransferase
MM271_14235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MM271_14240	COG1492	cobalamin metabolic process
MM271_14250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MM271_14255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MM271_14260	COG1120	ATPase activity
MM271_14265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_14270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MM271_14275	COG0716	FMN binding
MM271_14280	COG5002	protein histidine kinase activity
MM271_14285	COG0745	RESPONSE REGULATOR receiver
MM271_14290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MM271_14295	COG1333	cytochrome c biogenesis protein
MM271_14300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_14305	COG1187	pseudouridine synthase activity
MM271_14310	COG0700	Nucleoside recognition
MM271_14315	COG2715	membrane protein required for spore maturation
MM271_14320	COG1686	Belongs to the peptidase S11 family
MM271_14325	COG2323	membrane
MM271_14330	COG2323	membrane
MM271_14345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM271_14370	COG2323	membrane
MM271_14380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MM271_14400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MM271_14405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MM271_14410	COG1547	Domain of unknown function (DUF309)
MM271_14420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MM271_14425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MM271_14425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MM271_14430	COG0307	riboflavin synthase, alpha
MM271_14435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MM271_14435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MM271_14440	COG3011	Protein conserved in bacteria
MM271_14445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MM271_14450	COG0019	diaminopimelate decarboxylase activity
MM271_14455	COG0697	spore germination
MM271_14470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM271_14495	COG2172	sigma factor antagonist activity
MM271_14505	COG1686	Belongs to the peptidase S11 family
MM271_14510	COG0840	transmembrane signaling receptor activity
MM271_14525	COG2070	2-Nitropropane dioxygenase
MM271_14530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MM271_14540	COG1024	Enoyl-CoA hydratase
MM271_14545	COG0183	Belongs to the thiolase family
MM271_14550	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM271_14555	COG1012	belongs to the aldehyde dehydrogenase family
MM271_14560	COG1024	Enoyl-CoA hydratase
MM271_14575	COG2151	metal-sulfur cluster biosynthetic enzyme
MM271_14590	COG3396	Phenylacetate-CoA oxygenase
MM271_14595	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MM271_14600	COG4989	oxidoreductase activity
MM271_14605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MM271_14610	COG1279	arginine transmembrane transporter activity
MM271_14635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM271_14640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MM271_14660	COG0456	acetyltransferase
MM271_14670	COG1183	phosphatidylcholine synthase activity
MM271_14690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MM271_14695	COG0569	domain protein
MM271_14705	COG1253	flavin adenine dinucleotide binding
MM271_14725	COG4191	Histidine kinase
MM271_14740	COG1247	-acetyltransferase
MM271_14745	COG1012	belongs to the aldehyde dehydrogenase family
MM271_14765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MM271_14770	COG1376	ErfK ybiS ycfS ynhG family protein
MM271_14775	COG3403	YqcI/YcgG family
MM271_14800	COG3708	Transcriptional regulator
MM271_14805	COG1199	ATP-dependent helicase activity
MM271_14810	COG5002	protein histidine kinase activity
MM271_14815	COG0745	RESPONSE REGULATOR receiver
MM271_14820	COG2208	phosphoserine phosphatase activity
MM271_14835	COG0840	transmembrane signaling receptor activity
MM271_14840	COG1744	ABC transporter substrate-binding protein PnrA-like
MM271_14845	COG1368	sulfuric ester hydrolase activity
MM271_14875	COG0471	metal ion transport
MM271_14875	COG3273	potassium ion transport
MM271_14885	COG1725	Transcriptional regulator
MM271_14890	COG1131	(ABC) transporter
MM271_14895	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MM271_14915	COG2247	cell wall binding repeat
MM271_14915	COG2385	sporulation resulting in formation of a cellular spore
MM271_14920	COG1744	ABC transporter substrate-binding protein PnrA-like
MM271_14925	COG3845	ABC transporter
MM271_14930	COG4603	Belongs to the binding-protein-dependent transport system permease family
MM271_14935	COG1079	Belongs to the binding-protein-dependent transport system permease family
MM271_14950	COG1063	alcohol dehydrogenase
MM271_14960	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_14970	COG2045	Belongs to the ComB family
MM271_14975	COG1809	phosphosulfolactate synthase activity
MM271_14985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_14995	COG0542	response to heat
MM271_15000	COG1454	alcohol dehydrogenase
MM271_15000	COG1012	belongs to the aldehyde dehydrogenase family
MM271_15025	COG1388	LysM domain
MM271_15025	COG3858	chitin binding
MM271_15035	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM271_15040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM271_15055	COG0861	Integral membrane protein TerC family
MM271_15060	COG1329	Transcriptional regulator
MM271_15075	COG2404	hydrolase activity, acting on ester bonds
MM271_15095	COG2357	RelA SpoT domain protein
MM271_15115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM271_15115	COG0551	DNA topoisomerase type I activity
MM271_15120	COG0840	transmembrane signaling receptor activity
MM271_15120	COG3290	protein histidine kinase activity
MM271_15135	COG0514	ATP-dependent DNA helicase (RecQ)
MM271_15145	COG2329	Antibiotic biosynthesis monooxygenase
MM271_15150	COG0488	(ABC) transporter
MM271_15155	COG0697	spore germination
MM271_15180	COG5582	Belongs to the UPF0302 family
MM271_15190	COG0577	efflux transmembrane transporter activity
MM271_15195	COG1136	(ABC) transporter
MM271_15200	COG0456	acetyltransferase
MM271_15210	COG2962	Rard protein
MM271_15220	COG0523	cobalamin synthesis protein
MM271_15235	COG2368	4-hydroxyphenylacetate
MM271_15240	COG2208	phosphoserine phosphatase activity
MM271_15250	COG0508	dehydrogenase complex catalyzes the overall conversion of
MM271_15255	COG0567	Dehydrogenase, E1 component
MM271_15260	COG1294	oxidase, subunit
MM271_15265	COG1271	oxidase subunit
MM271_15275	COG1011	Hydrolase
MM271_15295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MM271_15300	COG3285	dna ligase
MM271_15300	COG1793	dna ligase
MM271_15305	COG1227	inorganic diphosphatase activity
MM271_15310	COG0840	transmembrane signaling receptor activity
MM271_15315	COG3546	catalase activity
MM271_15340	COG2309	aminopeptidase activity
MM271_15345	COG0667	Aldo Keto reductase
MM271_15355	COG0657	acetylesterase activity
MM271_15365	COG4841	protein insertion into membrane
MM271_15370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MM271_15375	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MM271_15405	COG3852	Histidine kinase
MM271_15410	COG0835	chemotaxis
MM271_15410	COG0784	Response regulator, receiver
MM271_15415	COG1119	ATPase activity
MM271_15445	COG2311	Membrane
MM271_15455	COG2200	EAL domain
MM271_15465	COG0701	Predicted permease
MM271_15470	COG2267	carboxylic ester hydrolase activity
MM271_15485	COG3437	response regulator, receiver
MM271_15485	COG2770	Histidine kinase
MM271_15490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MM271_15495	COG0328	RNA-DNA hybrid ribonuclease activity
MM271_15505	COG0613	PHP domain protein
MM271_15515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MM271_15520	COG0824	Thioesterase
MM271_15525	COG0464	growth
MM271_15530	COG0697	spore germination
MM271_15535	COG0124	histidyl-tRNA synthetase
MM271_15540	COG1063	alcohol dehydrogenase
MM271_15560	COG0398	Pfam SNARE associated Golgi protein
MM271_15585	COG2323	membrane
MM271_15600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MM271_15635	COG1418	mRNA catabolic process
MM271_15640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MM271_15665	COG5002	protein histidine kinase activity
MM271_15670	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MM271_15720	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_15725	COG3773	Cell wall hydrolase
MM271_15740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MM271_15750	COG0300	oxidoreductase activity
MM271_15770	COG0583	DNA-binding transcription factor activity
MM271_15785	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_15790	COG0183	Belongs to the thiolase family
MM271_15795	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM271_15800	COG2508	Transcriptional regulator
MM271_15820	COG0179	Fumarylacetoacetate (FAA) hydrolase
MM271_15830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MM271_15835	COG1414	Transcriptional regulator
MM271_15860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MM271_15875	COG1216	Glycosyl transferase, family 2
MM271_15875	COG0438	transferase activity, transferring glycosyl groups
MM271_15895	COG2133	pyrroloquinoline quinone binding
MM271_15910	COG4214	carbohydrate transport
MM271_15915	COG1129	ABC transporter
MM271_15920	COG4213	ABC transporter substrate-binding protein
MM271_15930	COG4753	response regulator
MM271_15930	COG2207	Transcriptional regulator
MM271_15935	COG2972	Histidine kinase
MM271_15965	COG4641	Protein conserved in bacteria
MM271_15970	COG0613	PHP domain protein
MM271_15985	COG0463	Glycosyl transferase, family 2
MM271_15995	COG0438	transferase activity, transferring glycosyl groups
MM271_16020	COG1086	Polysaccharide biosynthesis protein
MM271_16035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MM271_16040	COG1091	dTDP-4-dehydrorhamnose reductase activity
MM271_16045	COG1088	dTDP-glucose 4,6-dehydratase activity
MM271_16050	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MM271_16110	COG4846	Membrane protein involved in cytochrome C biogenesis
MM271_16125	COG1937	Protein conserved in bacteria
MM271_16135	COG1132	(ABC) transporter
MM271_16140	COG1132	(ABC) transporter
MM271_16145	COG3763	UPF0154 protein
MM271_16155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MM271_16160	COG4224	UPF0291 protein
MM271_16165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MM271_16175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MM271_16180	COG3397	chitin binding
MM271_16190	COG0174	glutamine synthetase
MM271_16195	COG0789	Transcriptional regulator
MM271_16200	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MM271_16205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MM271_16210	COG0464	growth
MM271_16220	COG1923	regulation of RNA biosynthetic process
MM271_16225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MM271_16230	COG2136	Putative SAM-dependent methyltransferase
MM271_16230	COG2521	methyltransferase
MM271_16235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MM271_16240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MM271_16250	COG4550	Control of competence regulator ComK, YlbF/YmcA
MM271_16255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM271_16260	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM271_16270	COG2359	stage V sporulation protein S
MM271_16275	COG1692	metallophosphoesterase
MM271_16280	COG1418	mRNA catabolic process
MM271_16285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MM271_16290	COG0513	Belongs to the DEAD box helicase family
MM271_16295	COG1058	Belongs to the CinA family
MM271_16295	COG1546	Belongs to the CinA family
MM271_16300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MM271_16305	COG1666	GTP binding
MM271_16310	COG1426	Protein conserved in bacteria
MM271_16325	COG0300	oxidoreductase activity
MM271_16330	COG0612	Peptidase, M16
MM271_16335	COG0612	Peptidase, M16
MM271_16340	COG2188	Transcriptional regulator
MM271_16345	COG1674	ftsk spoiiie
MM271_16355	COG0740	serine-type endopeptidase activity
MM271_16360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MM271_16370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MM271_16375	COG0527	aspartate kinase activity
MM271_16380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MM271_16385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MM271_16390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MM271_16395	COG1873	PFAM PRC-barrel domain
MM271_16400	COG0612	Peptidase, M16
MM271_16405	COG0726	polysaccharide deacetylase
MM271_16410	COG1185	polyribonucleotide nucleotidyltransferase activity
MM271_16415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MM271_16420	COG0196	riboflavin kinase activity
MM271_16425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MM271_16430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MM271_16435	COG1550	Protein conserved in bacteria
MM271_16440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MM271_16445	COG1358	cellular component organization or biogenesis
MM271_16450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MM271_16455	COG0195	Participates in both transcription termination and antitermination
MM271_16460	COG0779	Required for maturation of 30S ribosomal subunits
MM271_16465	COG2176	DNA-directed DNA polymerase activity
MM271_16470	COG0442	prolyl-tRNA aminoacylation
MM271_16475	COG0750	zinc metalloprotease
MM271_16480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MM271_16485	COG4589	Belongs to the CDS family
MM271_16490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MM271_16495	COG0233	cytoplasmic translational termination
MM271_16500	COG0528	UMP kinase activity
MM271_16505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MM271_16510	COG0052	Belongs to the universal ribosomal protein uS2 family
MM271_16530	COG1191	sigma factor activity
MM271_16540	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MM271_16545	COG1776	CheC inhibitor of MCP methylation
MM271_16550	COG2201	protein-glutamate methylesterase activity
MM271_16555	COG0455	bacterial-type flagellum organization
MM271_16560	COG1419	protein localization to endoplasmic reticulum
MM271_16565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MM271_16570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MM271_16575	COG1684	flagellar biosynthetic protein fliR
MM271_16580	COG1987	bacterial-type flagellum assembly
MM271_16585	COG1338	Plays a role in the flagellum-specific transport system
MM271_16590	COG3190	flagellar
MM271_16595	COG2201	protein-glutamate methylesterase activity
MM271_16600	COG1776	CheC inhibitor of MCP methylation
MM271_16600	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MM271_16605	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MM271_16615	COG1582	Flagellar protein (FlbD)
MM271_16620	COG4786	Flagellar basal body rod
MM271_16630	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MM271_16645	COG2882	bacterial-type flagellum organization
MM271_16650	COG1157	protein secretion by the type III secretion system
MM271_16655	COG1317	bacterial-type flagellum organization
MM271_16660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MM271_16665	COG1766	The M ring may be actively involved in energy transduction
MM271_16670	COG1677	Flagellar hook-basal body complex protein FliE
MM271_16675	COG1558	bacterial-type flagellum-dependent cell motility
MM271_16680	COG1815	bacterial-type flagellum-dependent cell motility
MM271_16685	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MM271_16690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MM271_16695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MM271_16700	COG4974	Belongs to the 'phage' integrase family
MM271_16705	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MM271_16710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM271_16715	COG0758	DNA mediated transformation
MM271_16720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MM271_16725	COG0045	succinate-CoA ligase (ADP-forming) activity
MM271_16740	COG2257	FlhB HrpN YscU SpaS Family
MM271_16750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MM271_16765	COG0335	large ribosomal subunit rRNA binding
MM271_16770	COG0336	Belongs to the RNA methyltransferase TrmD family
MM271_16775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MM271_16785	COG1837	Belongs to the UPF0109 family
MM271_16790	COG0228	four-way junction DNA binding
MM271_16795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MM271_16800	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MM271_16805	COG0552	protein localization to endoplasmic reticulum
MM271_16810	COG1196	nuclear chromosome segregation
MM271_16815	COG4840	Belongs to the UPF0435 family
MM271_16820	COG0571	ribonuclease III activity
MM271_16825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MM271_16830	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_16835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MM271_16840	COG0416	fatty acid biosynthetic process
MM271_16845	COG1349	DNA-binding transcription factor activity
MM271_16850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MM271_16855	COG1760	l-serine dehydratase
MM271_16860	COG1760	l-serine dehydratase
MM271_16865	COG1461	Dihydroxyacetone kinase
MM271_16870	COG1302	Protein conserved in bacteria
MM271_16875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MM271_16885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MM271_16890	COG1162	GTPase activity
MM271_16895	COG0515	serine threonine protein kinase
MM271_16895	COG2815	serine threonine protein kinase
MM271_16900	COG0631	protein serine/threonine phosphatase activity
MM271_16905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MM271_16910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MM271_16910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MM271_16915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MM271_16920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MM271_16925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MM271_16930	COG1758	RNA polymerase activity
MM271_16935	COG0194	GDP metabolic process
MM271_16940	COG2052	Domain of unknown function (DUF370)
MM271_16945	COG1561	YicC-like family, N-terminal region
MM271_16950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MM271_16960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MM271_16965	COG0284	orotidine-5'-phosphate decarboxylase activity
MM271_16970	COG0167	dihydroorotate dehydrogenase activity
MM271_16975	COG0543	2 iron, 2 sulfur cluster binding
MM271_16980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MM271_16985	COG0505	Belongs to the CarA family
MM271_16990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MM271_16995	COG0540	Belongs to the ATCase OTCase family
MM271_17000	COG2233	PERMEase
MM271_17005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MM271_17010	COG0564	pseudouridine synthase activity
MM271_17015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MM271_17020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MM271_17025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MM271_17030	COG3599	regulation of cell shape
MM271_17035	COG2302	S4 RNA-binding domain
MM271_17040	COG0762	integral membrane protein
MM271_17045	COG1799	cell septum assembly
MM271_17050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MM271_17055	COG1496	oxidoreductase activity
MM271_17060	COG1873	PFAM PRC-barrel domain
MM271_17065	COG1191	sigma factor activity
MM271_17070	COG1191	sigma factor activity
MM271_17080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MM271_17085	COG0849	cell division
MM271_17090	COG3856	small basic protein
MM271_17100	COG3879	Bacterial protein of unknown function (DUF881)
MM271_17105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MM271_17110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MM271_17115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MM271_17120	COG0772	Belongs to the SEDS family
MM271_17125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MM271_17130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MM271_17135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MM271_17140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM271_17145	COG0768	penicillin binding
MM271_17150	COG0768	penicillin binding
MM271_17155	COG4839	cell division protein FtsL
MM271_17160	COG0275	rRNA processing
MM271_17165	COG2001	Belongs to the MraZ family
MM271_17170	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MM271_17180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MM271_17185	COG0454	-acetyltransferase
MM271_17195	COG1024	Enoyl-CoA hydratase
MM271_17200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MM271_17205	COG1399	metal-binding, possibly nucleic acid-binding protein
MM271_17210	COG1323	Belongs to the UPF0348 family
MM271_17215	COG3480	Lon protease (S16) C-terminal proteolytic domain
MM271_17220	COG1752	Esterase of the alpha-beta hydrolase superfamily
MM271_17225	COG3314	Sporulation integral membrane protein YlbJ
MM271_17230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MM271_17235	COG0742	ribosomal rna small subunit methyltransferase
MM271_17250	COG4471	UPF0298 protein
MM271_17260	COG3679	Belongs to the UPF0342 family
MM271_17265	COG4294	response to UV
MM271_17290	COG2050	protein possibly involved in aromatic compounds catabolism
MM271_17305	COG2340	Cysteine-rich secretory protein family
MM271_17315	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MM271_17335	COG0628	permease
MM271_17345	COG2322	membrane
MM271_17350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MM271_17355	COG1845	cytochrome c oxidase, subunit III
MM271_17360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MM271_17365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MM271_17365	COG2010	Cytochrome c
MM271_17370	COG0109	protoheme IX farnesyltransferase activity
MM271_17375	COG1612	heme a metabolic process
MM271_17385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MM271_17390	COG4838	Belongs to the UPF0358 family
MM271_17395	COG2066	Belongs to the glutaminase family
MM271_17400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MM271_17405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MM271_17415	COG4896	Protein conserved in bacteria
MM271_17430	COG1217	gtp-binding protein TYPA
MM271_17445	COG0483	inositol monophosphate 1-phosphatase activity
MM271_17455	COG4493	Belongs to the UPF0637 family
MM271_17460	COG4476	Belongs to the UPF0223 family
MM271_17465	COG1982	Orn Lys Arg decarboxylase major
MM271_17495	COG4129	membrane
MM271_17505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MM271_17510	COG0508	dehydrogenase complex catalyzes the overall conversion of
MM271_17515	COG0022	dehydrogenase e1 component
MM271_17525	COG0497	DNA recombination
MM271_17535	COG0242	peptide deformylase activity
MM271_17540	COG0561	phosphatase activity
MM271_17545	COG5503	Protein of unknown function (DUF1447)
MM271_17550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MM271_17560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_17565	COG0450	alkyl hydroperoxide reductase
MM271_17570	COG0668	transmembrane transport
MM271_17590	COG1473	amidohydrolase
MM271_17595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MM271_17600	COG2171	N-acyltransferase activity
MM271_17605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MM271_17610	COG2224	Isocitrate lyase
MM271_17615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MM271_17620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MM271_17625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MM271_17630	COG1116	anion transmembrane transporter activity
MM271_17635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM271_17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MM271_17655	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_17660	COG0668	transmembrane transport
MM271_17665	COG4980	gas vesicle protein
MM271_17670	COG1228	amidohydrolase
MM271_17675	COG2271	Major facilitator Superfamily
MM271_17680	COG0534	Mate efflux family protein
MM271_17685	COG3275	phosphorelay sensor kinase activity
MM271_17690	COG3279	Response regulator of the LytR AlgR family
MM271_17695	COG1966	Carbon starvation protein
MM271_17715	COG3534	alpha-L-arabinofuranosidase
MM271_17720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MM271_17725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MM271_17730	COG2160	L-arabinose isomerase activity
MM271_17735	COG0235	Class ii aldolase
MM271_17760	COG0246	Mannitol dehydrogenase
MM271_17765	COG2721	sulfolactate sulfo-lyase activity
MM271_17770	COG0385	Bile acid
MM271_17775	COG5578	integral membrane protein
MM271_17785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MM271_17810	COG0395	ABC-type sugar transport system, permease component
MM271_17815	COG4209	transmembrane transport
MM271_17820	COG1653	transport
MM271_17825	COG2207	Transcriptional regulator
MM271_17835	COG2755	lipolytic protein G-D-S-L family
MM271_17840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM271_17845	COG1904	glucuronate isomerase
MM271_17850	COG2182	Extracellular solute-binding protein
MM271_17855	COG0534	Mate efflux family protein
MM271_17860	COG3345	alpha-galactosidase
MM271_17865	COG2207	Transcriptional regulator
MM271_17880	COG1175	transmembrane transport
MM271_17895	COG1482	cell wall glycoprotein biosynthetic process
MM271_17905	COG2942	2-epimerase
MM271_17910	COG1609	Transcriptional regulator
MM271_17915	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MM271_17930	COG2190	(PTS) system
MM271_17935	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_17940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MM271_17945	COG1024	Enoyl-CoA hydratase
MM271_17950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM271_17955	COG0511	ligase activity, forming carbon-carbon bonds
MM271_17960	COG0439	Biotin carboxylase
MM271_17965	COG1960	acyl-CoA dehydrogenase activity
MM271_17970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MM271_17975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MM271_17980	COG0183	Belongs to the thiolase family
MM271_17985	COG0583	DNA-binding transcription factor activity
MM271_18005	COG2357	RelA SpoT domain protein
MM271_18015	COG5002	protein histidine kinase activity
MM271_18020	COG0745	RESPONSE REGULATOR receiver
MM271_18025	COG0475	glutathione-regulated potassium exporter activity
MM271_18030	COG0490	domain, Protein
MM271_18040	COG3483	tryptophan 2,3-dioxygenase activity
MM271_18045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MM271_18050	COG3844	kynureninase activity
MM271_18070	COG0662	Cupin 2, conserved barrel domain protein
MM271_18070	COG2207	Transcriptional regulator
MM271_18075	COG2239	Acts as a magnesium transporter
MM271_18080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_18090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MM271_18130	COG5002	protein histidine kinase activity
MM271_18135	COG0745	RESPONSE REGULATOR receiver
MM271_18155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MM271_18160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MM271_18160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MM271_18170	COG1725	Transcriptional regulator
MM271_18175	COG0114	fumarate hydratase activity
MM271_18185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MM271_18190	COG2382	esterase
MM271_18195	COG2153	protein acetylation
MM271_18200	COG1970	mechanosensitive ion channel activity
MM271_18205	COG1403	HNH endonuclease
MM271_18210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_18235	COG1126	abc transporter atp-binding protein
MM271_18240	COG0765	amino acid transport
MM271_18245	COG4597	amino acid ABC transporter
MM271_18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM271_18255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MM271_18280	COG0475	glutathione-regulated potassium exporter activity
MM271_18280	COG0589	response to stress
MM271_18285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MM271_18295	COG0564	pseudouridine synthase activity
MM271_18300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MM271_18305	COG2357	RelA SpoT domain protein
MM271_18315	COG4116	CYTH
MM271_18330	COG2346	COG2346, Truncated hemoglobins
MM271_18335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MM271_18345	COG1164	Oligoendopeptidase f
MM271_18355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM271_18360	COG4862	establishment of competence for transformation
MM271_18365	COG0861	Integral membrane protein TerC family
MM271_18370	COG1393	Belongs to the ArsC family
MM271_18385	COG0456	acetyltransferase
MM271_18400	COG0166	Belongs to the GPI family
MM271_18405	COG1272	protein, Hemolysin III
MM271_18410	COG1418	mRNA catabolic process
MM271_18420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_18425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MM271_18430	COG0180	Tryptophanyl-tRNA synthetase
MM271_18445	COG5504	Zn-dependent protease
MM271_18455	COG1597	lipid kinase activity
MM271_18460	COG5609	conserved protein (DUF2294)
MM271_18470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM271_18485	COG1686	Belongs to the peptidase S11 family
MM271_18490	COG3773	Cell wall hydrolase
MM271_18495	COG0617	tRNA 3'-terminal CCA addition
MM271_18495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MM271_18495	COG3620	sequence-specific DNA binding
MM271_18500	COG1595	DNA-templated transcription, initiation
MM271_18510	COG1316	TRANSCRIPTIONal
MM271_18515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MM271_18520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM271_18530	COG1744	ABC transporter substrate-binding protein PnrA-like
MM271_18535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MM271_18545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM271_18550	COG2267	carboxylic ester hydrolase activity
MM271_18570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MM271_18575	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MM271_18585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MM271_18595	COG0723	plastoquinol--plastocyanin reductase activity
MM271_18600	COG0437	4 iron, 4 sulfur cluster binding
MM271_18605	COG0243	molybdopterin cofactor binding
MM271_18625	COG4149	molybdate abc transporter
MM271_18630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MM271_18640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MM271_18645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MM271_18650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MM271_18655	COG0505	Belongs to the CarA family
MM271_18665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MM271_18670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MM271_18675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MM271_18685	COG1999	signal sequence binding
MM271_18690	COG3336	cytochrome c oxidase
MM271_18695	COG0561	phosphatase activity
MM271_18715	COG1396	sequence-specific DNA binding
MM271_18720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MM271_18740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MM271_18755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_18760	COG1073	alpha beta
MM271_18775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MM271_18780	COG0628	permease
MM271_18785	COG1917	Cupin 2, conserved barrel domain protein
MM271_18785	COG2207	Transcriptional regulator
MM271_18790	COG0534	Mate efflux family protein
MM271_18800	COG2358	TRAP transporter, solute receptor (TAXI family
MM271_18815	COG1509	lysine 2,3-aminomutase activity
MM271_18820	COG0840	transmembrane signaling receptor activity
MM271_18830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM271_18835	COG0179	Fumarylacetoacetate (FAA) hydrolase
MM271_18840	COG3706	GGDEF domain
MM271_18845	COG1404	Belongs to the peptidase S8 family
MM271_18850	COG0431	NADPH-dependent FMN reductase
MM271_18865	COG0778	Nitroreductase
MM271_18870	COG0084	hydrolase, TatD family'
MM271_18875	COG2200	EAL domain
MM271_18890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_18890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_18895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_18895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_18900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MM271_18905	COG1309	transcriptional regulator
MM271_18910	COG0183	Belongs to the thiolase family
MM271_18935	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MM271_18945	COG0475	glutathione-regulated potassium exporter activity
MM271_18950	COG0490	domain, Protein
MM271_18955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MM271_18960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MM271_18970	COG2201	protein-glutamate methylesterase activity
MM271_18975	COG0835	chemotaxis
MM271_18980	COG0643	Histidine kinase
MM271_18980	COG2198	Histidine kinase
MM271_18990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MM271_19010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MM271_19015	COG3639	organic phosphonate transmembrane transporter activity
MM271_19020	COG3639	organic phosphonate transmembrane transporter activity
MM271_19030	COG5578	integral membrane protein
MM271_19040	COG0395	ABC-type sugar transport system, permease component
MM271_19045	COG1175	transmembrane transport
MM271_19055	COG2723	6-phospho-beta-galactosidase activity
MM271_19070	COG0704	Plays a role in the regulation of phosphate uptake
MM271_19075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MM271_19080	COG0581	inorganic phosphate transmembrane transporter activity
MM271_19085	COG0573	inorganic phosphate transmembrane transporter activity
MM271_19095	COG1234	tRNA 3'-trailer cleavage
MM271_19100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MM271_19105	COG2868	ribosomal protein
MM271_19110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MM271_19115	COG1530	ribonuclease E activity
MM271_19125	COG1994	Peptidase M50
MM271_19130	COG0739	heme binding
MM271_19135	COG0746	molybdenum cofactor guanylyltransferase activity
MM271_19140	COG1357	PFAM Pentapeptide repeats (8 copies)
MM271_19145	COG2258	MOSC domain
MM271_19150	COG0243	molybdopterin cofactor binding
MM271_19155	COG2146	nitrite reductase [NAD(P)H] activity
MM271_19160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM271_19165	COG0521	Mo-molybdopterin cofactor biosynthetic process
MM271_19170	COG0315	cyclic pyranopterin monophosphate synthase activity
MM271_19175	COG2894	cell division
MM271_19180	COG0850	regulation of cytokinetic process
MM271_19190	COG1792	Involved in formation and maintenance of cell shape
MM271_19195	COG1077	Cell shape determining protein MreB Mrl
MM271_19200	COG2003	Belongs to the UPF0758 family
MM271_19215	COG2843	Capsule synthesis protein
MM271_19235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MM271_19255	COG1459	type II secretion system
MM271_19265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MM271_19320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM271_19360	COG0285	dihydrofolate synthase activity
MM271_19365	COG0525	valine-tRNA ligase activity
MM271_19385	COG1388	LysM domain
MM271_19390	COG2190	(PTS) system
MM271_19390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MM271_19390	COG1263	PTS System
MM271_19395	COG3711	transcriptional antiterminator
MM271_19400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MM271_19405	COG0113	porphobilinogen synthase activity
MM271_19415	COG0181	hydroxymethylbilane synthase activity
MM271_19420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MM271_19425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MM271_19435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MM271_19445	COG1067	ATP-dependent peptidase activity
MM271_19445	COG0470	DNA polymerase III
MM271_19450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MM271_19455	COG0544	peptidyl-prolyl cis-trans isomerase activity
MM271_19460	COG1477	protein flavinylation
MM271_19460	COG0457	Tetratricopeptide repeat
MM271_19465	COG0066	3-isopropylmalate dehydratase activity
MM271_19470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MM271_19475	COG0473	3-isopropylmalate dehydrogenase activity
MM271_19480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM271_19485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MM271_19490	COG0440	acetolactate synthase activity
MM271_19495	COG0028	Belongs to the TPP enzyme family
MM271_19500	COG0129	dihydroxy-acid dehydratase activity
MM271_19520	COG0622	Phosphoesterase
MM271_19525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MM271_19530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MM271_19535	COG5401	PFAM Sporulation and spore germination
MM271_19540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MM271_19545	COG1846	Transcriptional regulator
MM271_19555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MM271_19560	COG3711	transcriptional antiterminator
MM271_19565	COG2197	response regulator
MM271_19570	COG0824	Thioesterase
MM271_19575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MM271_19580	COG1053	succinate dehydrogenase
MM271_19585	COG2009	succinate dehydrogenase
MM271_19590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MM271_19595	COG1719	4-vinyl reductase, 4VR
MM271_19605	COG0322	excinuclease ABC activity
MM271_19610	COG3118	belongs to the thioredoxin family
MM271_19615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MM271_19620	COG2086	electron transfer activity
MM271_19625	COG1024	Enoyl-CoA hydratase
MM271_19630	COG1309	transcriptional regulator
MM271_19635	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_19640	COG1929	Belongs to the glycerate kinase type-1 family
MM271_19645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MM271_19650	COG0318	PFAM AMP-dependent synthetase and ligase
MM271_19655	COG3766	membrane
MM271_19660	COG1193	negative regulation of DNA recombination
MM271_19665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MM271_19665	COG1796	DNA polymerase
MM271_19670	COG1286	toxin biosynthetic process
MM271_19675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MM271_19680	COG0072	phenylalanine-tRNA ligase activity
MM271_19680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM271_19685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MM271_19690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MM271_19700	COG1363	Peptidase, m42
MM271_19720	COG3326	Membrane
MM271_19725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MM271_19730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MM271_19735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MM271_19745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MM271_19755	COG2205	protein histidine kinase activity
MM271_19760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MM271_19765	COG1484	DNA-dependent DNA replication
MM271_19770	COG3611	Membrane attachment protein
MM271_19775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MM271_19785	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MM271_19790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MM271_19795	COG0237	dephospho-CoA kinase activity
MM271_19800	COG1971	Probably functions as a manganese efflux pump
MM271_19810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM271_19810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM271_19815	COG0330	HflC and HflK could
MM271_19820	COG0330	HflC and HflK could
MM271_19825	COG5002	protein histidine kinase activity
MM271_19830	COG0745	RESPONSE REGULATOR receiver
MM271_19835	COG0039	L-malate dehydrogenase activity
MM271_19840	COG0538	isocitrate dehydrogenase activity
MM271_19845	COG0372	Belongs to the citrate synthase family
MM271_19850	COG2707	UPF0756 membrane protein
MM271_19855	COG0628	permease
MM271_19860	COG3030	protein affecting phage T7 exclusion by the F plasmid
MM271_19870	COG0205	6-phosphofructokinase activity
MM271_19875	COG0825	malonyl-CoA metabolic process
MM271_19880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MM271_19885	COG2186	Transcriptional regulator
MM271_19890	COG0281	malic enzyme
MM271_19895	COG0587	DNA-directed DNA polymerase activity
MM271_19910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MM271_19920	COG4109	DRTGG domain
MM271_19930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MM271_19935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_19940	COG0686	Belongs to the AlaDH PNT family
MM271_19950	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
MM271_19955	COG0492	ferredoxin-NADP+ reductase activity
MM271_19955	COG3118	belongs to the thioredoxin family
MM271_19965	COG0589	response to stress
MM271_19970	COG0165	Argininosuccinate lyase
MM271_19975	COG0137	argininosuccinate synthase activity
MM271_19990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MM271_19995	COG0827	DNA restriction-modification system
MM271_20000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MM271_20005	COG3874	Sporulation protein YtfJ
MM271_20015	COG1714	RDD family
MM271_20020	COG0616	signal peptide processing
MM271_20025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MM271_20030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MM271_20040	COG0301	tRNA thio-modification
MM271_20045	COG1104	cysteine desulfurase activity
MM271_20050	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MM271_20055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MM271_20060	COG1309	transcriptional regulator
MM271_20065	COG1956	GAF domain-containing protein
MM271_20070	COG2203	Gaf domain
MM271_20070	COG2199	diguanylate cyclase activity
MM271_20075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MM271_20090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MM271_20095	COG0454	-acetyltransferase
MM271_20100	COG0517	IMP dehydrogenase activity
MM271_20105	COG0123	including yeast histone deacetylase and acetoin utilization protein
MM271_20110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MM271_20115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MM271_20120	COG1609	Transcriptional regulator
MM271_20125	COG1605	Chorismate mutase
MM271_20125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MM271_20130	COG0849	cell division
MM271_20135	COG3118	belongs to the thioredoxin family
MM271_20140	COG4980	gas vesicle protein
MM271_20155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MM271_20165	COG1674	ftsk spoiiie
MM271_20170	COG4848	Belongs to the UPF0354 family
MM271_20175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MM271_20195	COG1363	Peptidase, m42
MM271_20210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MM271_20215	COG0602	queuosine metabolic process
MM271_20220	COG0720	synthase
MM271_20235	COG1131	(ABC) transporter
MM271_20245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MM271_20245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MM271_20245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MM271_20250	COG1105	Belongs to the carbohydrate kinase PfkB family
MM271_20255	COG1349	DNA-binding transcription factor activity
MM271_20260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM271_20265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MM271_20285	COG0510	thiamine kinase activity
MM271_20290	COG1523	belongs to the glycosyl hydrolase 13 family
MM271_20295	COG0788	formyltetrahydrofolate deformylase activity
MM271_20310	COG1346	cytolysis
MM271_20315	COG1380	Effector of murein hydrolase LrgA
MM271_20325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MM271_20330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MM271_20335	COG1349	DNA-binding transcription factor activity
MM271_20340	COG1187	pseudouridine synthase activity
MM271_20355	COG0772	Belongs to the SEDS family
MM271_20360	COG0772	Belongs to the SEDS family
MM271_20375	COG2244	polysaccharide biosynthetic process
MM271_20380	COG0432	Pfam Uncharacterised protein family UPF0047
MM271_20400	COG2081	HI0933 family
MM271_20405	COG0495	leucyl-tRNA aminoacylation
MM271_20410	COG2814	Major facilitator Superfamily
MM271_20415	COG1242	4 iron, 4 sulfur cluster binding
MM271_20420	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MM271_20430	COG2267	carboxylic ester hydrolase activity
MM271_20435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MM271_20440	COG0671	phosphoesterase, PA-phosphatase related
MM271_20450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM271_20455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MM271_20465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MM271_20470	COG1506	peptidase
MM271_20475	COG0494	nUDIX hydrolase
MM271_20480	COG2814	Major facilitator Superfamily
MM271_20495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MM271_20515	COG3328	transposase activity
MM271_20535	COG1609	Transcriptional regulator
MM271_20545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MM271_20550	COG2814	Major facilitator Superfamily
MM271_20570	COG1940	carbohydrate kinase activity
MM271_20590	COG1609	Transcriptional regulator
MM271_20595	COG5001	Diguanylate cyclase
MM271_20595	COG3300	MHYT domain
MM271_20600	COG1012	belongs to the aldehyde dehydrogenase family
MM271_20610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MM271_20615	COG3829	transcription factor binding
MM271_20620	COG3314	Sporulation integral membrane protein YlbJ
MM271_20630	COG0840	transmembrane signaling receptor activity
MM271_20645	COG3940	Belongs to the glycosyl hydrolase 43 family
MM271_20650	COG0395	ABC-type sugar transport system, permease component
MM271_20655	COG1175	transmembrane transport
MM271_20660	COG1653	transport
MM271_20665	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_20670	COG1312	Catalyzes the dehydration of D-mannonate
MM271_20680	COG0395	ABC-type sugar transport system, permease component
MM271_20685	COG4209	transmembrane transport
MM271_20695	COG5578	integral membrane protein
MM271_20710	COG2972	Histidine kinase
MM271_20715	COG2207	Transcriptional regulator
MM271_20715	COG4753	response regulator
MM271_20720	COG5578	integral membrane protein
MM271_20725	COG3507	Belongs to the glycosyl hydrolase 43 family
MM271_20735	COG1609	Transcriptional regulator
MM271_20745	COG1349	DNA-binding transcription factor activity
MM271_20755	COG1011	Hydrolase
MM271_20760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MM271_20765	COG2207	Transcriptional regulator
MM271_20765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MM271_20770	COG0778	Nitroreductase
MM271_20775	COG1120	ATPase activity
MM271_20780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_20785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_20790	COG1360	Flagellar Motor Protein
MM271_20795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MM271_20800	COG1609	Transcriptional regulator
MM271_20825	COG0038	chloride channel
MM271_20830	COG2323	membrane
MM271_20840	COG1136	(ABC) transporter
MM271_20845	COG0577	efflux transmembrane transporter activity
MM271_20845	COG1136	(ABC) transporter
MM271_20855	COG1131	(ABC) transporter
MM271_20865	COG1309	transcriptional regulator
MM271_20880	COG1472	Belongs to the glycosyl hydrolase 3 family
MM271_20900	COG5002	protein histidine kinase activity
MM271_20945	COG0166	Belongs to the GPI family
MM271_20950	COG1979	alcohol dehydrogenase
MM271_20955	COG2155	Conserved Protein
MM271_20960	COG1098	S1 RNA binding domain
MM271_20970	COG0436	Aminotransferase
MM271_20975	COG1522	sequence-specific DNA binding
MM271_20980	COG1335	isochorismatase
MM271_20985	COG1854	S-ribosylhomocysteine lyase activity
MM271_20995	COG1295	ribonuclease BN
MM271_21010	COG1511	domain protein
MM271_21015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MM271_21035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MM271_21040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MM271_21045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MM271_21050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MM271_21060	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MM271_21070	COG3584	3D domain protein
MM271_21085	COG1252	NADH dehydrogenase
MM271_21090	COG0492	ferredoxin-NADP+ reductase activity
MM271_21095	COG0316	Belongs to the HesB IscA family
MM271_21105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MM271_21110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MM271_21120	COG4844	belongs to the
MM271_21130	COG1252	NADH dehydrogenase
MM271_21135	COG4837	Protein of unknown function (DUF1462)
MM271_21140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MM271_21145	COG0083	homoserine kinase activity
MM271_21150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MM271_21155	COG0460	homoserine dehydrogenase
MM271_21160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MM271_21165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MM271_21170	COG0647	UMP catabolic process
MM271_21180	COG2445	Protein of unknown function DUF86
MM271_21195	COG4470	Protein conserved in bacteria
MM271_21205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MM271_21210	COG0739	heme binding
MM271_21220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MM271_21235	COG3377	Domain of unknown function (DUF1805)
MM271_21240	COG0737	Belongs to the 5'-nucleotidase family
MM271_21245	COG0730	response to heat
MM271_21250	COG1801	Protein of unknown function DUF72
MM271_21260	COG0719	Fe-S assembly protein
MM271_21265	COG0822	iron-sulfur transferase activity
MM271_21270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM271_21275	COG0719	Fe-S assembly protein
MM271_21280	COG0396	ATPase activity
MM271_21285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MM271_21300	COG1464	Belongs to the NlpA lipoprotein family
MM271_21305	COG2011	ABC-type metal ion transport system permease component
MM271_21310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MM271_21330	COG0509	glycine decarboxylation via glycine cleavage system
MM271_21335	COG1393	Belongs to the ArsC family
MM271_21345	COG1960	acyl-CoA dehydrogenase activity
MM271_21350	COG0183	Belongs to the thiolase family
MM271_21355	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM271_21355	COG1024	Enoyl-CoA hydratase
MM271_21365	COG5577	PFAM Coat F domain
MM271_21405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MM271_21410	COG1131	(ABC) transporter
MM271_21425	COG1104	cysteine desulfurase activity
MM271_21435	COG0246	Mannitol dehydrogenase
MM271_21440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MM271_21445	COG3711	transcriptional antiterminator
MM271_21455	COG3546	catalase activity
MM271_21470	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MM271_21480	COG1120	ATPase activity
MM271_21485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_21490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM271_21500	COG2207	Transcriptional regulator
MM271_21500	COG1917	Cupin 2, conserved barrel domain protein
MM271_21520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MM271_21525	COG3764	Sortase (surface protein transpeptidase)
MM271_21535	COG0557	exoribonuclease II activity
MM271_21540	COG1647	Serine aminopeptidase, S33
MM271_21545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MM271_21555	COG0148	phosphopyruvate hydratase activity
MM271_21560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MM271_21570	COG0126	phosphoglycerate kinase activity
MM271_21575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MM271_21590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MM271_21595	COG0740	serine-type endopeptidase activity
MM271_21600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MM271_21605	COG1481	regulation of sporulation
MM271_21610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MM271_21615	COG1660	Displays ATPase and GTPase activities
MM271_21620	COG1051	belongs to the nudix hydrolase family
MM271_21625	COG0492	ferredoxin-NADP+ reductase activity
MM271_21630	COG0457	Tetratricopeptide repeat
MM271_21635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MM271_21635	COG0140	phosphoribosyl-ATP diphosphatase activity
MM271_21640	COG0107	imidazoleglycerol-phosphate synthase activity
MM271_21645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MM271_21650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MM271_21655	COG0131	Imidazoleglycerol-phosphate dehydratase
MM271_21660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MM271_21665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MM271_21670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MM271_21685	COG0110	maltose O-acetyltransferase activity
MM271_21690	COG0546	phosphoglycolate phosphatase activity
MM271_21695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MM271_21700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MM271_21705	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MM271_21710	COG1950	PFAM Membrane protein of
MM271_21715	COG3595	metallopeptidase activity
MM271_21720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MM271_21725	COG0556	nucleotide-excision repair
MM271_21740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM271_21745	COG0793	Belongs to the peptidase S41A family
MM271_21745	COG3409	Peptidoglycan-binding domain 1 protein
MM271_21750	COG0363	glucosamine-6-phosphate deaminase activity
MM271_21755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MM271_21760	COG4821	SIS domain
MM271_21765	COG2188	Transcriptional regulator
MM271_21775	COG1175	transmembrane transport
MM271_21785	COG0791	NLP P60 protein
MM271_21785	COG3883	PFAM NLP P60 protein
MM271_21790	COG2177	Part of the ABC transporter FtsEX involved in
MM271_21795	COG2884	Cell division ATP-binding protein ftsE
MM271_21805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MM271_21840	COG0653	protein targeting
MM271_21895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MM271_21905	COG1278	Cold shock
MM271_21920	COG1516	flagellar protein fliS
MM271_21925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MM271_21930	COG1334	flagellar protein FlaG
MM271_21945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MM271_21950	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MM271_21960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MM271_21965	COG4786	Flagellar basal body rod
MM271_21965	COG1256	bacterial-type flagellum assembly
MM271_21985	COG1040	competence protein
MM271_21990	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MM271_21995	COG1307	EDD domain protein, DegV family
MM271_22010	COG1739	Uncharacterized protein family UPF0029
MM271_22015	COG1316	TRANSCRIPTIONal
MM271_22020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MM271_22025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM271_22030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MM271_22040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM271_22040	COG1181	Belongs to the D-alanine--D-alanine ligase family
MM271_22045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM271_22045	COG0189	ligase activity
MM271_22055	COG0463	Glycosyl transferase, family 2
MM271_22060	COG1216	Glycosyl transferase, family 2
MM271_22060	COG1442	glycosyl transferase family 8
MM271_22075	COG1215	transferase activity, transferring glycosyl groups
MM271_22085	COG0438	transferase activity, transferring glycosyl groups
MM271_22090	COG2247	cell wall binding repeat
MM271_22090	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM271_22095	COG1404	Belongs to the peptidase S8 family
MM271_22125	COG0346	lactoylglutathione lyase activity
MM271_22135	COG3012	SEC-C Motif Domain Protein
MM271_22160	COG3842	ATPase activity
MM271_22165	COG4149	molybdate abc transporter
MM271_22175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MM271_22185	COG2072	flavoprotein involved in K transport
MM271_22190	COG1522	sequence-specific DNA binding
MM271_22195	COG1335	isochorismatase
MM271_22200	COG3813	Protein conserved in bacteria
MM271_22210	COG0347	Belongs to the P(II) protein family
MM271_22245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MM271_22280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MM271_22310	COG1215	transferase activity, transferring glycosyl groups
MM271_22320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MM271_22335	COG4464	protein tyrosine phosphatase activity
MM271_22340	COG0489	protein tyrosine kinase activity
MM271_22345	COG3944	biosynthesis protein
MM271_22350	COG1316	TRANSCRIPTIONal
MM271_22355	COG0791	NLP P60 protein
MM271_22355	COG1388	LysM domain
MM271_22375	COG2112	serine threonine protein kinase
MM271_22380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MM271_22415	COG4786	Flagellar basal body rod
MM271_22420	COG4786	Flagellar basal body rod
MM271_22430	COG1609	Transcriptional regulator
MM271_22440	COG0840	transmembrane signaling receptor activity
MM271_22465	COG2723	6-phospho-beta-galactosidase activity
MM271_22470	COG1263	PTS System
MM271_22470	COG2190	(PTS) system
MM271_22470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MM271_22475	COG3711	transcriptional antiterminator
MM271_22485	COG3764	Sortase (surface protein transpeptidase)
MM271_22505	COG0516	GMP reductase activity
MM271_22505	COG0517	IMP dehydrogenase activity
MM271_22510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MM271_22540	COG1131	(ABC) transporter
MM271_22545	COG2197	response regulator
MM271_22550	COG4585	Histidine kinase
MM271_22555	COG0739	heme binding
MM271_22560	COG2385	sporulation resulting in formation of a cellular spore
MM271_22565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MM271_22580	COG1007	ATP synthesis coupled electron transport
MM271_22585	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM271_22590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MM271_22595	COG0713	ATP synthesis coupled electron transport
MM271_22600	COG0839	Belongs to the complex I subunit 6 family
MM271_22610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MM271_22615	COG0649	NAD binding
MM271_22620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM271_22625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM271_22630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM271_22650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MM271_22655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MM271_22660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MM271_22665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MM271_22670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MM271_22675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MM271_22685	COG0356	it plays a direct role in the translocation of protons across the membrane
MM271_22695	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
MM271_22700	COG1404	Belongs to the peptidase S8 family
MM271_22705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MM271_22710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MM271_22720	COG0698	ribose 5-phosphate isomerase
MM271_22725	COG0840	transmembrane signaling receptor activity
MM271_22735	COG1971	Probably functions as a manganese efflux pump
MM271_22740	COG0009	L-threonylcarbamoyladenylate synthase
MM271_22755	COG2890	protein-(glutamine-N5) methyltransferase activity
MM271_22760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MM271_22765	COG0446	pyridine nucleotide-disulphide oxidoreductase
MM271_22775	COG1435	thymidine kinase activity
MM271_22780	COG0010	Belongs to the arginase family
MM271_22785	COG1228	amidohydrolase
MM271_22790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MM271_22805	COG0254	rRNA binding
MM271_22810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MM271_22815	COG1494	fructose-1,6-bisphosphatase
MM271_22820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MM271_22825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MM271_22830	COG0191	fructose-bisphosphate aldolase activity
MM271_22835	COG2204	response regulator
MM271_22845	COG0504	CTP synthase activity
MM271_22850	COG3343	RNA polymerase activity
MM271_22855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_22855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MM271_22855	COG1703	isobutyryl-CoA mutase activity
MM271_22865	COG1960	acyl-CoA dehydrogenase activity
MM271_22870	COG1960	acyl-CoA dehydrogenase activity
MM271_22875	COG1250	3-hydroxyacyl-CoA dehydrogenase
MM271_22880	COG0183	Belongs to the thiolase family
MM271_22885	COG2181	nitrate reductase activity
MM271_22885	COG0247	lactate metabolic process
MM271_22890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MM271_22895	COG0596	Alpha beta hydrolase
MM271_22905	COG0018	arginyl-trna synthetase
MM271_22915	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MM271_22920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MM271_22930	COG3465	dGTPase activity
MM271_22935	COG1078	dGTPase activity
MM271_22940	COG4844	belongs to the
MM271_22945	COG0095	Lipoate-protein ligase
MM271_22950	COG0280	phosphate acetyltransferase
MM271_22955	COG1902	pentaerythritol trinitrate reductase activity
MM271_22955	COG0446	pyridine nucleotide-disulphide oxidoreductase
MM271_22960	COG1024	Enoyl-CoA hydratase
MM271_22965	COG3253	May function as heme-dependent peroxidase
MM271_22970	COG3773	Cell wall hydrolase
MM271_22980	COG2363	Small membrane protein
MM271_22990	COG4191	Histidine kinase
MM271_23000	COG0789	Transcriptional regulator
MM271_23005	COG2176	DNA-directed DNA polymerase activity
MM271_23015	COG0004	ammonium transporteR
MM271_23020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MM271_23045	COG2199	diguanylate cyclase activity
MM271_23045	COG2203	Gaf domain
MM271_23055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MM271_23065	COG0402	S-adenosylhomocysteine deaminase activity
MM271_23070	COG1757	Na H antiporter
MM271_23095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MM271_23100	COG1028	Short-chain dehydrogenase reductase Sdr
MM271_23115	COG0513	Belongs to the DEAD box helicase family
MM271_23120	COG0753	catalase activity
MM271_23150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MM271_23165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM271_23170	COG2957	Belongs to the agmatine deiminase family
MM271_23175	COG2094	Belongs to the DNA glycosylase MPG family
MM271_23190	COG3706	GGDEF domain
MM271_23195	COG1876	peptidase activity
MM271_23210	COG1794	racemase activity, acting on amino acids and derivatives
MM271_23220	COG0367	asparagine synthase
MM271_23225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MM271_23230	COG1181	Belongs to the D-alanine--D-alanine ligase family
MM271_23240	COG4191	Histidine kinase
MM271_23245	COG5002	protein histidine kinase activity
MM271_23250	COG2059	Chromate
MM271_23265	COG1078	dGTPase activity
MM271_23275	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MM271_23280	COG1874	Beta-galactosidase
MM271_23285	COG3833	ABC-type maltose transport systems, permease component
MM271_23290	COG1175	transmembrane transport
MM271_23295	COG2182	Extracellular solute-binding protein
MM271_23300	COG1609	Transcriptional regulator
MM271_23305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MM271_23315	COG1136	(ABC) transporter
MM271_23320	COG0577	efflux transmembrane transporter activity
MM271_23330	COG2208	phosphoserine phosphatase activity
MM271_23335	COG0579	oxidoreductase
MM271_23375	COG1136	(ABC) transporter
MM271_23380	COG3850	Histidine kinase
MM271_23380	COG5002	protein histidine kinase activity
MM271_23385	COG0745	RESPONSE REGULATOR receiver
MM271_23390	COG0778	Nitroreductase
MM271_23415	COG1309	transcriptional regulator
MM271_23420	COG1082	Xylose isomerase domain protein TIM barrel
MM271_23460	COG1187	pseudouridine synthase activity
MM271_23495	COG4473	ABC transporter
MM271_23545	COG0277	FAD linked oxidase domain protein
MM271_23565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM271_23570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MM271_23575	COG4853	Protein conserved in bacteria
MM271_23585	COG5002	protein histidine kinase activity
MM271_23590	COG0745	RESPONSE REGULATOR receiver
MM271_23595	COG1388	LysM domain
MM271_23595	COG4942	peptidase
MM271_23625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MM271_23630	COG0305	Participates in initiation and elongation during chromosome replication
MM271_23635	COG0359	binds to the 23S rRNA
MM271_23640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MM271_23645	COG4241	membrane
MM271_23650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MM271_23655	COG0629	single-stranded DNA binding
MM271_23660	COG0360	Binds together with S18 to 16S ribosomal RNA
MM271_23665	COG0012	GTP binding
MM271_23670	COG4481	Protein conserved in bacteria
MM271_23675	COG3949	Membrane
MM271_23695	COG1475	DNA binding
MM271_23700	COG1192	Involved in chromosome partitioning
MM271_23705	COG1475	DNA binding
MM271_23715	COG0445	tRNA wobble uridine modification
MM271_23720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MM271_23730	COG1847	R3H domain protein
MM271_23735	COG0706	membrane insertase activity
MM271_23740	COG0594	ribonuclease P activity
MM271_23745	COG0230	Belongs to the bacterial ribosomal protein bL34 family