locus-tag	class	description
Mlg_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mlg_0002	COG0592	DNA-directed DNA polymerase activity
Mlg_0004	COG0187	DNA topoisomerase II activity
Mlg_0007	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Mlg_0010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Mlg_0011	COG0751	glycine-tRNA ligase activity
Mlg_0012	COG0752	glycyl-tRNA synthetase alpha subunit
Mlg_0013	COG0174	glutamine synthetase
Mlg_0015	COG3852	Histidine kinase
Mlg_0017	COG0602	queuosine metabolic process
Mlg_0019	COG0459	protein refolding
Mlg_0020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mlg_0021	COG1324	tolerance protein
Mlg_0022	COG4232	protein-disulfide reductase activity
Mlg_0023	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mlg_0024	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Mlg_0025	COG0511	ligase activity, forming carbon-carbon bonds
Mlg_0026	COG0439	Biotin carboxylase
Mlg_0028	COG0730	response to heat
Mlg_0030	COG0617	tRNA 3'-terminal CCA addition
Mlg_0032	COG0667	Aldo Keto reductase
Mlg_0033	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Mlg_0034	COG2022	thiamine diphosphate biosynthetic process
Mlg_0043	COG3501	Rhs element vgr protein
Mlg_0054	COG2204	response regulator
Mlg_0061	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Mlg_0064	COG1309	transcriptional regulator
Mlg_0065	COG0604	alcohol dehydrogenase
Mlg_0066	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Mlg_0067	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Mlg_0069	COG2226	methyltransferase
Mlg_0071	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Mlg_0072	COG1166	arginine decarboxylase activity
Mlg_0073	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Mlg_0075	COG1714	RDD family
Mlg_0076	COG0390	transport system, permease component
Mlg_0077	COG3842	ATPase activity
Mlg_0079	COG0004	ammonium transporteR
Mlg_0081	COG2960	long-chain fatty acid transporting porin activity
Mlg_0084	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mlg_0086	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Mlg_0087	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Mlg_0090	COG0543	2 iron, 2 sulfur cluster binding
Mlg_0090	COG0633	Ferredoxin
Mlg_0091	COG0477	Major facilitator Superfamily
Mlg_0094	COG3094	Invasion gene expression up-regulator, SirB
Mlg_0095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mlg_0100	COG0662	Cupin 2, conserved barrel domain protein
Mlg_0100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Mlg_0105	COG2226	methyltransferase
Mlg_0115	COG0463	Glycosyl transferase, family 2
Mlg_0122	COG1132	(ABC) transporter
Mlg_0125	COG0318	PFAM AMP-dependent synthetase and ligase
Mlg_0127	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mlg_0130	COG1834	amidinotransferase
Mlg_0132	COG1216	Glycosyl transferase, family 2
Mlg_0133	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mlg_0136	COG0438	transferase activity, transferring glycosyl groups
Mlg_0137	COG0438	transferase activity, transferring glycosyl groups
Mlg_0138	COG0367	asparagine synthase
Mlg_0139	COG0438	transferase activity, transferring glycosyl groups
Mlg_0144	COG3267	Type II secretory pathway component ExeA
Mlg_0144	COG3409	Peptidoglycan-binding domain 1 protein
Mlg_0146	COG0489	protein tyrosine kinase activity
Mlg_0158	COG0643	Histidine kinase
Mlg_0158	COG2198	Histidine kinase
Mlg_0159	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Mlg_0162	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Mlg_0164	COG3706	GGDEF domain
Mlg_0165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Mlg_0166	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mlg_0167	COG0154	amidase activity
Mlg_0168	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mlg_0169	COG1077	Cell shape determining protein MreB Mrl
Mlg_0170	COG1792	Involved in formation and maintenance of cell shape
Mlg_0172	COG0768	penicillin binding
Mlg_0173	COG0772	Belongs to the SEDS family
Mlg_0174	COG2951	lytic endotransglycosylase activity
Mlg_0176	COG1686	Belongs to the peptidase S11 family
Mlg_0178	COG2921	Belongs to the UPF0250 family
Mlg_0179	COG0321	lipoyl(octanoyl) transferase activity
Mlg_0181	COG0829	nickel cation binding
Mlg_0182	COG0831	urea catabolic process
Mlg_0183	COG0832	Belongs to the urease beta subunit family
Mlg_0184	COG0804	urea catabolic process
Mlg_0185	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Mlg_0186	COG0830	nickel cation binding
Mlg_0187	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Mlg_0189	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mlg_0197	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Mlg_0199	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Mlg_0200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mlg_0201	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mlg_0205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Mlg_0208	COG1309	transcriptional regulator
Mlg_0212	COG1047	Peptidyl-prolyl cis-trans
Mlg_0215	COG0437	4 iron, 4 sulfur cluster binding
Mlg_0216	COG0243	molybdopterin cofactor binding
Mlg_0219	COG4191	Histidine kinase
Mlg_0221	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Mlg_0222	COG2967	ApaG domain
Mlg_0223	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mlg_0225	COG1331	Highly conserved protein containing a thioredoxin domain
Mlg_0226	COG1959	2 iron, 2 sulfur cluster binding
Mlg_0228	COG0523	cobalamin synthesis protein
Mlg_0232	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Mlg_0235	COG0069	glutamate synthase activity
Mlg_0242	COG0823	Involved in the tonB-independent uptake of proteins
Mlg_0246	COG0281	malic enzyme
Mlg_0246	COG0280	phosphate acetyltransferase
Mlg_0248	COG0492	ferredoxin-NADP+ reductase activity
Mlg_0261	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Mlg_0267	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mlg_0269	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Mlg_0270	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mlg_0271	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mlg_0272	COG2890	protein-(glutamine-N5) methyltransferase activity
Mlg_0273	COG2835	tetraacyldisaccharide 4'-kinase activity
Mlg_0274	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Mlg_0275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Mlg_0276	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Mlg_0277	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Mlg_0278	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Mlg_0279	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mlg_0281	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Mlg_0282	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Mlg_0283	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mlg_0284	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Mlg_0285	COG0193	aminoacyl-tRNA hydrolase activity
Mlg_0286	COG0012	GTP binding
Mlg_0290	COG0166	Belongs to the GPI family
Mlg_0292	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mlg_0293	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mlg_0294	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Mlg_0300	COG1612	heme a metabolic process
Mlg_0301	COG0109	protoheme IX farnesyltransferase activity
Mlg_0307	COG0277	FAD linked oxidase domain protein
Mlg_0308	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mlg_0312	COG0003	Pfam Anion-transporting ATPase
Mlg_0314	COG1966	Carbon starvation protein
Mlg_0315	COG0589	response to stress
Mlg_0317	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mlg_0318	COG3118	belongs to the thioredoxin family
Mlg_0319	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mlg_0320	COG0071	Belongs to the small heat shock protein (HSP20) family
Mlg_0323	COG2217	Heavy metal translocating P-type atpase
Mlg_0327	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Mlg_0328	COG2885	chlorophyll binding
Mlg_0330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Mlg_0330	COG0425	Belongs to the sulfur carrier protein TusA family
Mlg_0332	COG0616	signal peptide processing
Mlg_0334	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Mlg_0335	COG0123	including yeast histone deacetylase and acetoin utilization protein
Mlg_0336	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Mlg_0337	COG2813	Specifically methylates the guanine in position
Mlg_0337	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mlg_0338	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mlg_0345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Mlg_0346	COG0540	Belongs to the ATCase OTCase family
Mlg_0347	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Mlg_0348	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Mlg_0349	COG1678	Uncharacterized ACR, COG1678
Mlg_0358	COG0840	transmembrane signaling receptor activity
Mlg_0359	COG0643	Histidine kinase
Mlg_0359	COG2198	Histidine kinase
Mlg_0361	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Mlg_0363	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Mlg_0363	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mlg_0366	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mlg_0367	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mlg_0369	COG1011	Hydrolase
Mlg_0370	COG0494	nUDIX hydrolase
Mlg_0371	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Mlg_0373	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Mlg_0374	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mlg_0375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mlg_0375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mlg_0378	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mlg_0379	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mlg_0380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Mlg_0383	COG4372	Transposase
Mlg_0390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Mlg_0391	COG5265	(ABC) transporter
Mlg_0392	COG5285	phytanoyl-CoA dioxygenase
Mlg_0394	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mlg_0395	COG1702	phosphate starvation-inducible protein PhoH
Mlg_0396	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mlg_0397	COG4535	Mg2 and Co2 transporter CorC
Mlg_0398	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mlg_0400	COG0495	leucyl-tRNA aminoacylation
Mlg_0402	COG1466	dna polymerase III delta subunit
Mlg_0403	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Mlg_0404	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Mlg_0406	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Mlg_0408	COG0424	maF-like protein
Mlg_0409	COG1530	ribonuclease E activity
Mlg_0411	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mlg_0412	COG0312	modulator of DNA gyrase
Mlg_0413	COG0312	modulator of DNA gyrase
Mlg_0417	COG2133	pyrroloquinoline quinone binding
Mlg_0418	COG0129	dihydroxy-acid dehydratase activity
Mlg_0419	COG2096	Adenosyltransferase
Mlg_0424	COG1346	cytolysis
Mlg_0425	COG1380	Effector of murein hydrolase LrgA
Mlg_0427	COG0494	nUDIX hydrolase
Mlg_0432	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mlg_0434	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mlg_0435	COG0316	Belongs to the HesB IscA family
Mlg_0436	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Mlg_0437	COG0739	heme binding
Mlg_0438	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Mlg_0439	COG1362	aminopeptidase activity
Mlg_0441	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Mlg_0443	COG3243	poly(R)-hydroxyalkanoic acid synthase
Mlg_0444	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mlg_0447	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mlg_0448	COG0081	regulation of translation
Mlg_0449	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Mlg_0450	COG0222	ribosome binding
Mlg_0451	COG0085	RNA polymerase activity
Mlg_0452	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mlg_0453	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Mlg_0454	COG0049	tRNA binding
Mlg_0455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mlg_0456	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mlg_0457	COG0051	transcription antitermination factor activity, RNA binding
Mlg_0458	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Mlg_0459	COG0088	Forms part of the polypeptide exit tunnel
Mlg_0460	COG0089	rRNA binding
Mlg_0461	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mlg_0462	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mlg_0463	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Mlg_0464	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mlg_0465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Mlg_0466	COG0255	Belongs to the universal ribosomal protein uL29 family
Mlg_0467	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Mlg_0468	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mlg_0469	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Mlg_0470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mlg_0471	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Mlg_0472	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mlg_0473	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mlg_0474	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Mlg_0475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mlg_0476	COG1841	ribosomal large subunit assembly
Mlg_0477	COG0200	Binds to the 23S rRNA
Mlg_0478	COG0201	protein transport
Mlg_0479	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Mlg_0480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mlg_0481	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mlg_0482	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mlg_0483	COG0202	RNA polymerase activity
Mlg_0484	COG0203	ribosomal protein L17
Mlg_0487	COG0039	L-malate dehydrogenase activity
Mlg_0489	COG0473	3-isopropylmalate dehydrogenase activity
Mlg_0490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mlg_0504	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Mlg_0511	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mlg_0515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Mlg_0516	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Mlg_0521	COG1295	ribonuclease BN
Mlg_0521	COG1959	2 iron, 2 sulfur cluster binding
Mlg_0522	COG1254	Belongs to the acylphosphatase family
Mlg_0532	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mlg_0532	COG3153	acetyltransferase
Mlg_0533	COG0729	surface antigen
Mlg_0535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mlg_0536	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mlg_0539	COG0442	prolyl-tRNA aminoacylation
Mlg_0540	COG5001	Diguanylate cyclase
Mlg_0540	COG3300	MHYT domain
Mlg_0544	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mlg_0549	COG1183	phosphatidylcholine synthase activity
Mlg_0550	COG0501	Belongs to the peptidase M48B family
Mlg_0551	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlg_0552	COG1573	uracil-dna glycosylase
Mlg_0553	COG1214	PFAM Peptidase M22, glycoprotease
Mlg_0553	COG0456	acetyltransferase
Mlg_0555	COG0525	valine-tRNA ligase activity
Mlg_0558	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Mlg_0559	COG0795	lipopolysaccharide-transporting ATPase activity
Mlg_0562	COG0617	tRNA 3'-terminal CCA addition
Mlg_0563	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Mlg_0564	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Mlg_0565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Mlg_0566	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Mlg_0568	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mlg_0568	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mlg_0569	COG0802	atpase or kinase
Mlg_0570	COG0860	N-Acetylmuramoyl-L-alanine amidase
Mlg_0571	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Mlg_0572	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Mlg_0573	COG1923	regulation of RNA biosynthetic process
Mlg_0574	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Mlg_0575	COG0330	HflC and HflK could
Mlg_0576	COG0330	HflC and HflK could
Mlg_0577	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Mlg_0578	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Mlg_0580	COG0557	exoribonuclease II activity
Mlg_0581	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mlg_0582	COG0360	Binds together with S18 to 16S ribosomal RNA
Mlg_0584	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Mlg_0586	COG0359	binds to the 23S rRNA
Mlg_0587	COG1372	Participates in initiation and elongation during chromosome replication
Mlg_0587	COG0305	Participates in initiation and elongation during chromosome replication
Mlg_0587	COG1372	Participates in initiation and elongation during chromosome replication
Mlg_0587	COG0305	Participates in initiation and elongation during chromosome replication
Mlg_0588	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Mlg_0591	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Mlg_0592	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Mlg_0595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Mlg_0596	COG1160	GTP binding
Mlg_0597	COG0418	dihydroorotase activity
Mlg_0599	COG3189	MarR family transcriptional regulator
Mlg_0600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Mlg_0601	COG0137	argininosuccinate synthase activity
Mlg_0602	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mlg_0604	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Mlg_0606	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Mlg_0608	COG2264	protein methyltransferase activity
Mlg_0612	COG0151	Belongs to the GarS family
Mlg_0620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Mlg_0620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Mlg_0623	COG0640	Transcriptional regulator
Mlg_0624	COG1104	cysteine desulfurase activity
Mlg_0625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Mlg_0626	COG2226	methyltransferase
Mlg_0628	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Mlg_0630	COG5001	Diguanylate cyclase
Mlg_0630	COG3706	GGDEF domain
Mlg_0630	COG4251	negative regulation of phosphorylation
Mlg_0630	COG2203	Gaf domain
Mlg_0631	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mlg_0633	COG0243	molybdopterin cofactor binding
Mlg_0636	COG0679	Auxin Efflux Carrier
Mlg_0637	COG0582	viral genome integration into host DNA
Mlg_0650	COG3501	Rhs element vgr protein
Mlg_0653	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mlg_0655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mlg_0656	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mlg_0657	COG3263	regulation of cellular component size
Mlg_0661	COG0517	IMP dehydrogenase activity
Mlg_0664	COG0473	3-isopropylmalate dehydrogenase activity
Mlg_0665	COG5001	Diguanylate cyclase
Mlg_0665	COG3300	MHYT domain
Mlg_0666	COG5002	protein histidine kinase activity
Mlg_0668	COG5002	protein histidine kinase activity
Mlg_0668	COG2176	DNA-directed DNA polymerase activity
Mlg_0669	COG0745	RESPONSE REGULATOR receiver
Mlg_0671	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mlg_0673	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlg_0675	COG3852	Histidine kinase
Mlg_0676	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mlg_0678	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Mlg_0679	COG1196	nuclear chromosome segregation
Mlg_0680	COG3115	cell septum assembly
Mlg_0681	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mlg_0683	COG1509	lysine 2,3-aminomutase activity
Mlg_0684	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Mlg_0685	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Mlg_0687	COG0613	PHP domain protein
Mlg_0688	COG0183	Belongs to the thiolase family
Mlg_0689	COG5001	Diguanylate cyclase
Mlg_0691	COG3706	GGDEF domain
Mlg_0693	COG1570	exodeoxyribonuclease VII activity
Mlg_0696	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mlg_0697	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mlg_0697	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mlg_0703	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Mlg_0706	COG3604	Transcriptional regulator
Mlg_0707	COG2204	response regulator
Mlg_0708	COG1677	Flagellar hook-basal body complex protein FliE
Mlg_0710	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Mlg_0715	COG0501	Belongs to the peptidase M48B family
Mlg_0718	COG2350	Protein conserved in bacteria
Mlg_0719	COG0009	L-threonylcarbamoyladenylate synthase
Mlg_0720	COG0180	Tryptophanyl-tRNA synthetase
Mlg_0721	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Mlg_0722	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mlg_0724	COG1959	2 iron, 2 sulfur cluster binding
Mlg_0725	COG0719	Fe-S assembly protein
Mlg_0726	COG0396	ATPase activity
Mlg_0727	COG0719	Fe-S assembly protein
Mlg_0728	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mlg_0732	COG4175	Glycine betaine
Mlg_0732	COG0517	IMP dehydrogenase activity
Mlg_0737	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Mlg_0740	COG1320	monovalent cation:proton antiporter activity
Mlg_0742	COG0713	ATP synthesis coupled electron transport
Mlg_0743	COG0651	ATP synthesis coupled electron transport
Mlg_0744	COG0651	ATP synthesis coupled electron transport
Mlg_0746	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Mlg_0748	COG3243	poly(R)-hydroxyalkanoic acid synthase
Mlg_0749	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mlg_0752	COG0398	Pfam SNARE associated Golgi protein
Mlg_0755	COG1215	transferase activity, transferring glycosyl groups
Mlg_0756	COG0640	Transcriptional regulator
Mlg_0757	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mlg_0760	COG5002	protein histidine kinase activity
Mlg_0760	COG5001	Diguanylate cyclase
Mlg_0760	COG3447	MASE1 domain protein
Mlg_0762	COG0776	regulation of translation
Mlg_0763	COG0072	phenylalanine-tRNA ligase activity
Mlg_0763	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mlg_0765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Mlg_0766	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Mlg_0768	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Mlg_0771	COG0189	ligase activity
Mlg_0771	COG4067	protein conserved in archaea
Mlg_0775	COG2308	Evidence 4 Homologs of previously reported genes of
Mlg_0784	COG0348	domain, Protein
Mlg_0785	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Mlg_0787	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mlg_0788	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mlg_0788	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mlg_0796	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Mlg_0798	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mlg_0800	COG3206	protein involved in exopolysaccharide biosynthesis
Mlg_0800	COG0489	protein tyrosine kinase activity
Mlg_0803	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Mlg_0804	COG1074	ATP-dependent DNA helicase activity
Mlg_0805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Mlg_0806	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mlg_0807	COG0586	Pfam SNARE associated Golgi protein
Mlg_0809	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Mlg_0810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mlg_0811	COG4660	Part of a membrane complex involved in electron transport
Mlg_0815	COG2878	Part of a membrane complex involved in electron transport
Mlg_0816	COG4657	Part of a membrane complex involved in electron transport
Mlg_0817	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mlg_0817	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mlg_0818	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Mlg_0820	COG0501	Belongs to the peptidase M48B family
Mlg_0821	COG1968	undecaprenyl-diphosphatase activity
Mlg_0824	COG2239	Acts as a magnesium transporter
Mlg_0825	COG0717	Belongs to the dCTP deaminase family
Mlg_0829	COG0450	alkyl hydroperoxide reductase
Mlg_0831	COG0720	synthase
Mlg_0833	COG0142	geranyltranstransferase activity
Mlg_0835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Mlg_0838	COG3501	Rhs element vgr protein
Mlg_0845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Mlg_0846	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Mlg_0847	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mlg_0848	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Mlg_0849	COG0268	Binds directly to 16S ribosomal RNA
Mlg_0851	COG0196	riboflavin kinase activity
Mlg_0852	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Mlg_0854	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mlg_0855	COG4968	Prepilin-type N-terminal cleavage methylation domain
Mlg_0862	COG0688	phosphatidylethanolamine metabolic process
Mlg_0866	COG2890	protein-(glutamine-N5) methyltransferase activity
Mlg_0867	COG0501	Belongs to the peptidase M48B family
Mlg_0870	COG0514	ATP-dependent DNA helicase (RecQ)
Mlg_0875	COG1012	belongs to the aldehyde dehydrogenase family
Mlg_0884	COG0228	four-way junction DNA binding
Mlg_0885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Mlg_0886	COG0336	Belongs to the RNA methyltransferase TrmD family
Mlg_0887	COG0335	large ribosomal subunit rRNA binding
Mlg_0891	COG0784	Response regulator, receiver
Mlg_0891	COG0835	chemotaxis
Mlg_0893	COG1815	bacterial-type flagellum-dependent cell motility
Mlg_0894	COG1558	bacterial-type flagellum-dependent cell motility
Mlg_0895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Mlg_0896	COG1749	Flagellar hook protein flgE
Mlg_0898	COG4786	Flagellar basal body rod
Mlg_0901	COG3951	Flagellar rod assembly protein muramidase FlgJ
Mlg_0901	COG1705	Flagellar rod assembly protein muramidase FlgJ
Mlg_0902	COG1256	bacterial-type flagellum assembly
Mlg_0905	COG1028	Short-chain dehydrogenase reductase Sdr
Mlg_0906	COG1562	ergosterol biosynthetic process
Mlg_0907	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mlg_0910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mlg_0911	COG0402	S-adenosylhomocysteine deaminase activity
Mlg_0912	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Mlg_0913	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mlg_0914	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mlg_0915	COG3047	cAMP biosynthetic process
Mlg_0920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Mlg_0922	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mlg_0924	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Mlg_0925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mlg_0928	COG0287	Prephenate dehydrogenase
Mlg_0929	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Mlg_0930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Mlg_0932	COG0776	regulation of translation
Mlg_0934	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Mlg_0935	COG0284	orotidine-5'-phosphate decarboxylase activity
Mlg_0936	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Mlg_0937	COG0586	Pfam SNARE associated Golgi protein
Mlg_0938	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Mlg_0942	COG0037	tRNA processing
Mlg_0943	COG1538	Outer membrane efflux protein
Mlg_0944	COG1469	GTP cyclohydrolase I activity
Mlg_0945	COG0142	geranyltranstransferase activity
Mlg_0946	COG1722	exodeoxyribonuclease VII activity
Mlg_0949	COG1518	maintenance of DNA repeat elements
Mlg_0955	COG1203	CRISPR-associated helicase, Cas3
Mlg_0957	COG0297	glycogen (starch) synthase activity
Mlg_0958	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Mlg_0959	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mlg_0971	COG1121	(ABC) transporter
Mlg_0979	COG1987	bacterial-type flagellum assembly
Mlg_0984	COG0455	bacterial-type flagellum organization
Mlg_0988	COG0643	Histidine kinase
Mlg_0988	COG2198	Histidine kinase
Mlg_0989	COG2201	protein-glutamate methylesterase activity
Mlg_0990	COG1192	Involved in chromosome partitioning
Mlg_0992	COG0835	chemotaxis
Mlg_0994	COG1028	Short-chain dehydrogenase reductase Sdr
Mlg_0995	COG1199	ATP-dependent helicase activity
Mlg_0997	COG2920	part of a sulfur-relay system
Mlg_1000	COG2181	nitrate reductase activity
Mlg_1001	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Mlg_1002	COG1140	nitrate reductase beta subunit
Mlg_1003	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Mlg_1005	COG3850	Histidine kinase
Mlg_1006	COG2197	response regulator
Mlg_1007	COG2223	nitrite transmembrane transporter activity
Mlg_1012	COG3706	GGDEF domain
Mlg_1016	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mlg_1016	COG0519	Catalyzes the synthesis of GMP from XMP
Mlg_1017	COG0590	tRNA wobble adenosine to inosine editing
Mlg_1018	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Mlg_1019	COG2329	Antibiotic biosynthesis monooxygenase
Mlg_1021	COG2832	Protein of unknown function (DUF454)
Mlg_1022	COG1444	tRNA N-acetyltransferase activity
Mlg_1023	COG0651	ATP synthesis coupled electron transport
Mlg_1025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mlg_1026	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Mlg_1029	COG4647	ligase activity
Mlg_1030	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
Mlg_1031	COG0145	ligase activity
Mlg_1034	COG3108	Peptidase M15
Mlg_1035	COG0301	tRNA thio-modification
Mlg_1036	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mlg_1037	COG1042	CoA-binding domain protein
Mlg_1037	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mlg_1037	COG0045	succinate-CoA ligase (ADP-forming) activity
Mlg_1040	COG0346	lactoylglutathione lyase activity
Mlg_1041	COG0803	Belongs to the bacterial solute-binding protein 9 family
Mlg_1042	COG1121	(ABC) transporter
Mlg_1043	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mlg_1045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Mlg_1046	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Mlg_1052	COG5001	Diguanylate cyclase
Mlg_1053	COG3447	MASE1 domain protein
Mlg_1053	COG5001	Diguanylate cyclase
Mlg_1053	COG5002	protein histidine kinase activity
Mlg_1059	COG1309	transcriptional regulator
Mlg_1060	COG0493	'glutamate synthase
Mlg_1060	COG0543	2 iron, 2 sulfur cluster binding
Mlg_1073	COG3901	Regulator of nitric oxide reductase transcription
Mlg_1073	COG0348	domain, Protein
Mlg_1074	COG4263	nitrous-oxide reductase activity
Mlg_1077	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Mlg_1085	COG0601	transmembrane transport
Mlg_1086	COG0747	negative chemotaxis
Mlg_1092	COG1131	(ABC) transporter
Mlg_1094	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mlg_1096	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Mlg_1097	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Mlg_1098	COG0840	transmembrane signaling receptor activity
Mlg_1101	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mlg_1102	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mlg_1109	COG5002	protein histidine kinase activity
Mlg_1109	COG5001	Diguanylate cyclase
Mlg_1110	COG3973	AAA domain
Mlg_1112	COG3290	protein histidine kinase activity
Mlg_1119	COG2823	Periplasmic or secreted lipoprotein
Mlg_1135	COG0573	inorganic phosphate transmembrane transporter activity
Mlg_1136	COG0581	inorganic phosphate transmembrane transporter activity
Mlg_1137	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mlg_1138	COG0704	Plays a role in the regulation of phosphate uptake
Mlg_1145	COG3501	Rhs element vgr protein
Mlg_1148	COG0745	RESPONSE REGULATOR receiver
Mlg_1149	COG2205	protein histidine kinase activity
Mlg_1154	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Mlg_1156	COG1199	ATP-dependent helicase activity
Mlg_1160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mlg_1162	COG2010	Cytochrome c
Mlg_1166	COG4536	flavin adenine dinucleotide binding
Mlg_1167	COG0662	Cupin 2, conserved barrel domain protein
Mlg_1168	COG1850	ribulose-bisphosphate carboxylase activity
Mlg_1170	COG3706	GGDEF domain
Mlg_1172	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mlg_1173	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Mlg_1175	COG0587	DNA-directed DNA polymerase activity
Mlg_1176	COG2814	Major facilitator Superfamily
Mlg_1177	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mlg_1177	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Mlg_1181	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mlg_1183	COG0011	TIGRFAM Protein of
Mlg_1185	COG1509	lysine 2,3-aminomutase activity
Mlg_1187	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mlg_1190	COG1917	Cupin 2, conserved barrel domain protein
Mlg_1191	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Mlg_1194	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Mlg_1195	COG0735	belongs to the Fur family
Mlg_1196	COG1121	(ABC) transporter
Mlg_1197	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mlg_1201	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mlg_1204	COG1127	ABC transporter
Mlg_1205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Mlg_1211	COG1058	Belongs to the CinA family
Mlg_1211	COG1546	Belongs to the CinA family
Mlg_1214	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Mlg_1215	COG0343	queuine tRNA-ribosyltransferase activity
Mlg_1216	COG1862	Preprotein translocase
Mlg_1217	COG1862	Preprotein translocase
Mlg_1218	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Mlg_1221	COG2766	serine protein kinase
Mlg_1222	COG2718	Belongs to the UPF0229 family
Mlg_1223	COG2719	SpoVR family
Mlg_1224	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Mlg_1224	COG0678	peroxiredoxin activity
Mlg_1226	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Mlg_1227	COG2814	Major facilitator Superfamily
Mlg_1228	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mlg_1229	COG0066	3-isopropylmalate dehydratase activity
Mlg_1230	COG0473	3-isopropylmalate dehydrogenase activity
Mlg_1235	COG0135	phosphoribosylanthranilate isomerase activity
Mlg_1236	COG0133	tryptophan synthase activity
Mlg_1237	COG0159	tryptophan synthase activity
Mlg_1238	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Mlg_1239	COG0285	dihydrofolate synthase activity
Mlg_1241	COG1286	toxin biosynthetic process
Mlg_1247	COG0316	Belongs to the HesB IscA family
Mlg_1248	COG0105	UTP biosynthetic process
Mlg_1249	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Mlg_1252	COG0124	histidyl-tRNA synthetase
Mlg_1253	COG2976	Protein conserved in bacteria
Mlg_1254	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mlg_1256	COG0563	adenylate kinase activity
Mlg_1258	COG1335	isochorismatase
Mlg_1260	COG0529	Catalyzes the synthesis of activated sulfate
Mlg_1260	COG2895	sulfate adenylyltransferase (ATP) activity
Mlg_1261	COG0175	sulfate reduction
Mlg_1262	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mlg_1262	COG1648	precorrin-2 dehydrogenase activity
Mlg_1263	COG0175	sulfate reduction
Mlg_1264	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mlg_1266	COG2863	cytochrome
Mlg_1267	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mlg_1273	COG2715	membrane protein required for spore maturation
Mlg_1276	COG0435	Glutathione S-transferase
Mlg_1277	COG0655	NAD(P)H dehydrogenase (quinone) activity
Mlg_1280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mlg_1286	COG3383	formate dehydrogenase (NAD+) activity
Mlg_1287	COG0437	4 iron, 4 sulfur cluster binding
Mlg_1293	COG0432	Pfam Uncharacterised protein family UPF0047
Mlg_1297	COG2414	aldehyde ferredoxin oxidoreductase
Mlg_1298	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Mlg_1299	COG0302	gtp cyclohydrolase
Mlg_1300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Mlg_1301	COG3706	GGDEF domain
Mlg_1301	COG0745	RESPONSE REGULATOR receiver
Mlg_1302	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mlg_1303	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Mlg_1304	COG0746	molybdenum cofactor guanylyltransferase activity
Mlg_1306	COG0640	Transcriptional regulator
Mlg_1308	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mlg_1309	COG2204	response regulator
Mlg_1314	COG0589	response to stress
Mlg_1315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Mlg_1316	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mlg_1318	COG1414	Transcriptional regulator
Mlg_1320	COG2154	pterin-4-alpha-carbinolamine dehydratase
Mlg_1321	COG0315	cyclic pyranopterin monophosphate synthase activity
Mlg_1323	COG0588	phosphoglycerate mutase activity
Mlg_1327	COG1472	Belongs to the glycosyl hydrolase 3 family
Mlg_1329	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mlg_1331	COG5508	conserved small protein
Mlg_1335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Mlg_1336	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Mlg_1341	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mlg_1343	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mlg_1344	COG0481	GTPase activity
Mlg_1347	COG0571	ribonuclease III activity
Mlg_1348	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Mlg_1349	COG1381	Involved in DNA repair and RecF pathway recombination
Mlg_1350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Mlg_1351	COG0736	holo-[acyl-carrier-protein] synthase activity
Mlg_1354	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Mlg_1355	COG0494	nUDIX hydrolase
Mlg_1361	COG1573	uracil-dna glycosylase
Mlg_1362	COG0322	excinuclease ABC activity
Mlg_1363	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Mlg_1366	COG2095	MarC family integral membrane protein
Mlg_1367	COG0300	oxidoreductase activity
Mlg_1368	COG1994	Peptidase M50
Mlg_1368	COG0517	IMP dehydrogenase activity
Mlg_1369	COG0745	RESPONSE REGULATOR receiver
Mlg_1369	COG3706	GGDEF domain
Mlg_1370	COG1132	(ABC) transporter
Mlg_1372	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mlg_1374	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mlg_1376	COG3852	Histidine kinase
Mlg_1377	COG2204	response regulator
Mlg_1378	COG0741	lytic transglycosylase activity
Mlg_1381	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Mlg_1382	COG2983	Belongs to the UPF0260 family
Mlg_1383	COG2217	Heavy metal translocating P-type atpase
Mlg_1389	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mlg_1390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mlg_1393	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Mlg_1397	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Mlg_1400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mlg_1403	COG0583	DNA-binding transcription factor activity
Mlg_1404	COG3038	cytochrome b561
Mlg_1407	COG1538	Outer membrane efflux protein
Mlg_1409	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mlg_1413	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mlg_1416	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Mlg_1417	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Mlg_1418	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Mlg_1419	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mlg_1420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mlg_1422	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mlg_1423	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mlg_1424	COG0416	fatty acid biosynthetic process
Mlg_1425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Mlg_1426	COG1399	metal-binding, possibly nucleic acid-binding protein
Mlg_1427	COG0424	maF-like protein
Mlg_1428	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Mlg_1428	COG0616	signal peptide processing
Mlg_1429	COG0564	pseudouridine synthase activity
Mlg_1430	COG1530	ribonuclease E activity
Mlg_1431	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mlg_1433	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Mlg_1434	COG1663	tetraacyldisaccharide 4'-kinase activity
Mlg_1435	COG0848	biopolymer transport protein
Mlg_1436	COG0811	peptide transport
Mlg_1437	COG2333	competence protein COMEC
Mlg_1437	COG0658	competence protein
Mlg_1439	COG1136	(ABC) transporter
Mlg_1440	COG4591	ABC-type transport system involved in lipoprotein release permease component
Mlg_1441	COG1489	DNA binding
Mlg_1444	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mlg_1445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Mlg_1446	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Mlg_1447	COG0542	response to heat
Mlg_1448	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Mlg_1451	COG0482	sulfurtransferase activity
Mlg_1452	COG2915	High frequency lysogenization protein hflD homolog
Mlg_1455	COG2885	chlorophyll binding
Mlg_1455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Mlg_1457	COG3956	TIGRFAM MazG family protein
Mlg_1458	COG1309	transcriptional regulator
Mlg_1459	COG0625	glutathione transferase activity
Mlg_1461	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Mlg_1463	COG0167	dihydroorotate dehydrogenase activity
Mlg_1464	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Mlg_1465	COG2951	lytic endotransglycosylase activity
Mlg_1468	COG1704	LemA family
Mlg_1469	COG1752	Esterase of the alpha-beta hydrolase superfamily
Mlg_1472	COG2183	response to ionizing radiation
Mlg_1473	COG1643	Atp-dependent helicase
Mlg_1479	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Mlg_1480	COG0527	aspartate kinase activity
Mlg_1481	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mlg_1482	COG2137	regulation of response to DNA damage stimulus
Mlg_1483	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Mlg_1484	COG1546	Belongs to the CinA family
Mlg_1485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mlg_1486	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Mlg_1487	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Mlg_1489	COG0330	HflC and HflK could
Mlg_1490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Mlg_1491	COG2166	iron-sulfur cluster assembly
Mlg_1494	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mlg_1497	COG4251	negative regulation of phosphorylation
Mlg_1498	COG2267	carboxylic ester hydrolase activity
Mlg_1499	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mlg_1501	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mlg_1502	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Mlg_1503	COG1162	GTPase activity
Mlg_1504	COG1360	Flagellar Motor Protein
Mlg_1507	COG0537	adenosine 5'-monophosphoramidase activity
Mlg_1508	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Mlg_1509	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Mlg_1510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Mlg_1511	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Mlg_1515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Mlg_1517	COG1067	ATP-dependent peptidase activity
Mlg_1521	COG0745	RESPONSE REGULATOR receiver
Mlg_1521	COG3706	GGDEF domain
Mlg_1522	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Mlg_1525	COG0463	Glycosyl transferase, family 2
Mlg_1526	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mlg_1528	COG1073	alpha beta
Mlg_1533	COG0582	viral genome integration into host DNA
Mlg_1536	COG4372	Transposase
Mlg_1538	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mlg_1540	COG1196	nuclear chromosome segregation
Mlg_1549	COG0463	Glycosyl transferase, family 2
Mlg_1550	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mlg_1553	COG0129	dihydroxy-acid dehydratase activity
Mlg_1557	COG0489	protein tyrosine kinase activity
Mlg_1559	COG0314	molybdopterin synthase activity
Mlg_1561	COG5000	phosphorelay sensor kinase activity
Mlg_1561	COG3279	Response regulator of the LytR AlgR family
Mlg_1567	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Mlg_1567	COG3608	succinylglutamate desuccinylase aspartoacylase
Mlg_1576	COG1136	(ABC) transporter
Mlg_1576	COG0577	efflux transmembrane transporter activity
Mlg_1579	COG0084	hydrolase, TatD family'
Mlg_1580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Mlg_1585	COG0494	nUDIX hydrolase
Mlg_1586	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Mlg_1592	COG0308	aminopeptidase N
Mlg_1593	COG0793	Belongs to the peptidase S41A family
Mlg_1594	COG1024	Enoyl-CoA hydratase
Mlg_1598	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Mlg_1599	COG1160	GTP binding
Mlg_1602	COG2095	MarC family integral membrane protein
Mlg_1605	COG1763	Mo-molybdopterin cofactor biosynthetic process
Mlg_1607	COG0519	Catalyzes the synthesis of GMP from XMP
Mlg_1607	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mlg_1608	COG1193	negative regulation of DNA recombination
Mlg_1611	COG2226	methyltransferase
Mlg_1612	COG1671	Belongs to the UPF0178 family
Mlg_1613	COG0513	Belongs to the DEAD box helicase family
Mlg_1616	COG1881	PFAM PEBP family protein
Mlg_1617	COG4251	negative regulation of phosphorylation
Mlg_1619	COG3706	GGDEF domain
Mlg_1620	COG4191	Histidine kinase
Mlg_1627	COG1643	Atp-dependent helicase
Mlg_1633	COG2226	methyltransferase
Mlg_1634	COG1595	DNA-templated transcription, initiation
Mlg_1636	COG2226	methyltransferase
Mlg_1637	COG0519	Catalyzes the synthesis of GMP from XMP
Mlg_1637	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mlg_1642	COG4191	Histidine kinase
Mlg_1643	COG4988	ABC transporter
Mlg_1644	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Mlg_1645	COG5001	Diguanylate cyclase
Mlg_1646	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Mlg_1653	COG2221	Nitrite and sulphite reductase 4Fe-4S
Mlg_1654	COG2221	Nitrite and sulphite reductase 4Fe-4S
Mlg_1655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Mlg_1656	COG2923	Belongs to the DsrF TusC family
Mlg_1658	COG2920	part of a sulfur-relay system
Mlg_1665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mlg_1666	COG1797	cobyrinic acid a,c-diamide synthase activity
Mlg_1669	COG2197	response regulator
Mlg_1670	COG4585	Histidine kinase
Mlg_1672	COG0425	Belongs to the sulfur carrier protein TusA family
Mlg_1674	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mlg_1675	COG0243	molybdopterin cofactor binding
Mlg_1676	COG0437	4 iron, 4 sulfur cluster binding
Mlg_1677	COG3302	dmso reductase anchor subunit
Mlg_1678	COG3005	denitrification pathway
Mlg_1679	COG1648	precorrin-2 dehydrogenase activity
Mlg_1679	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mlg_1680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Mlg_1683	COG4133	protoheme IX ABC transporter activity
Mlg_1686	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Mlg_1687	COG1138	Cytochrome C-type biogenesis protein
Mlg_1688	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mlg_1689	COG3088	subunit of a heme lyase
Mlg_1690	COG4235	cytochrome complex assembly
Mlg_1692	COG2027	D-alanyl-D-alanine carboxypeptidase
Mlg_1694	COG0628	permease
Mlg_1695	COG4191	Histidine kinase
Mlg_1696	COG2204	response regulator
Mlg_1699	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mlg_1700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mlg_1701	COG2146	nitrite reductase [NAD(P)H] activity
Mlg_1702	COG0243	molybdopterin cofactor binding
Mlg_1703	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mlg_1703	COG1116	anion transmembrane transporter activity
Mlg_1705	COG1116	anion transmembrane transporter activity
Mlg_1708	COG3707	response regulator
Mlg_1710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Mlg_1711	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Mlg_1712	COG1674	ftsk spoiiie
Mlg_1713	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Mlg_1714	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Mlg_1718	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mlg_1719	COG1960	acyl-CoA dehydrogenase activity
Mlg_1722	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mlg_1725	COG2081	HI0933 family
Mlg_1726	COG0121	glutamine amidotransferase
Mlg_1735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Mlg_1737	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mlg_1739	COG1283	sodium-dependent phosphate transmembrane transporter activity
Mlg_1753	COG1222	aaa ATPase
Mlg_1759	COG1575	Belongs to the MenA family. Type 1 subfamily
Mlg_1764	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mlg_1768	COG2610	gluconate transmembrane transporter activity
Mlg_1771	COG3977	Valine--pyruvate aminotransferase
Mlg_1772	COG0038	chloride channel
Mlg_1774	COG3239	Fatty acid desaturase
Mlg_1775	COG1214	PFAM Peptidase M22, glycoprotease
Mlg_1775	COG0456	acetyltransferase
Mlg_1776	COG0640	Transcriptional regulator
Mlg_1780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mlg_1783	COG4372	Transposase
Mlg_1787	COG2161	toxin-antitoxin pair type II binding
Mlg_1788	COG4974	Belongs to the 'phage' integrase family
Mlg_1793	COG4195	phage-related replication protein
Mlg_1798	COG0517	IMP dehydrogenase activity
Mlg_1800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Mlg_1802	COG5002	protein histidine kinase activity
Mlg_1804	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Mlg_1806	COG3706	GGDEF domain
Mlg_1808	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Mlg_1810	COG0215	cysteine-tRNA ligase activity
Mlg_1811	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mlg_1812	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mlg_1813	COG0352	thiamine-phosphate diphosphorylase activity
Mlg_1813	COG0351	phosphomethylpyrimidine kinase
Mlg_1815	COG1999	signal sequence binding
Mlg_1818	COG2738	Putative neutral zinc metallopeptidase
Mlg_1819	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Mlg_1821	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Mlg_1823	COG0436	Aminotransferase
Mlg_1826	COG1388	LysM domain
Mlg_1826	COG4942	peptidase
Mlg_1827	COG1238	metal cluster binding
Mlg_1828	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mlg_1829	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mlg_1831	COG3447	MASE1 domain protein
Mlg_1831	COG5001	Diguanylate cyclase
Mlg_1831	COG5002	protein histidine kinase activity
Mlg_1832	COG4566	intracellular signal transduction
Mlg_1833	COG4191	Histidine kinase
Mlg_1834	COG2197	response regulator
Mlg_1835	COG0585	pseudouridine synthase activity
Mlg_1836	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Mlg_1837	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Mlg_1838	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Mlg_1839	COG0148	phosphopyruvate hydratase activity
Mlg_1840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Mlg_1841	COG0504	CTP synthase activity
Mlg_1842	COG0037	tRNA processing
Mlg_1843	COG0825	malonyl-CoA metabolic process
Mlg_1847	COG0848	biopolymer transport protein
Mlg_1848	COG0811	peptide transport
Mlg_1850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Mlg_1851	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mlg_1852	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mlg_1853	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mlg_1857	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Mlg_1858	COG0575	Belongs to the CDS family
Mlg_1859	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mlg_1860	COG0233	cytoplasmic translational termination
Mlg_1861	COG0528	UMP kinase activity
Mlg_1862	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Mlg_1863	COG0052	Belongs to the universal ribosomal protein uS2 family
Mlg_1864	COG0024	Methionine aminopeptidase
Mlg_1866	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mlg_1867	COG2171	N-acyltransferase activity
Mlg_1868	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mlg_1871	COG0248	Ppx GppA phosphatase
Mlg_1872	COG2062	phosphohistidine phosphatase, SixA
Mlg_1873	COG3706	GGDEF domain
Mlg_1875	COG2217	Heavy metal translocating P-type atpase
Mlg_1877	COG0348	domain, Protein
Mlg_1879	COG2010	Cytochrome c
Mlg_1882	COG3278	Belongs to the heme-copper respiratory oxidase family
Mlg_1883	COG0714	Associated with various cellular activities
Mlg_1887	COG1959	2 iron, 2 sulfur cluster binding
Mlg_1889	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Mlg_1892	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Mlg_1894	COG0277	FAD linked oxidase domain protein
Mlg_1895	COG0277	FAD linked oxidase domain protein
Mlg_1896	COG0247	lactate metabolic process
Mlg_1898	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mlg_1899	COG0484	heat shock protein binding
Mlg_1900	COG0443	Heat shock 70 kDa protein
Mlg_1901	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Mlg_1902	COG1420	regulation of RNA biosynthetic process
Mlg_1903	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mlg_1904	COG0497	DNA recombination
Mlg_1905	COG0735	belongs to the Fur family
Mlg_1906	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mlg_1909	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Mlg_1912	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mlg_1912	COG4797	methyltransferase
Mlg_1923	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Mlg_1926	COG3608	succinylglutamate desuccinylase aspartoacylase
Mlg_1926	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Mlg_1929	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Mlg_1930	COG3300	MHYT domain
Mlg_1930	COG5001	Diguanylate cyclase
Mlg_1936	COG0471	metal ion transport
Mlg_1938	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mlg_1942	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Mlg_1943	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mlg_1944	COG1185	polyribonucleotide nucleotidyltransferase activity
Mlg_1945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Mlg_1946	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mlg_1947	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Mlg_1948	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mlg_1949	COG0195	Participates in both transcription termination and antitermination
Mlg_1949	COG2251	uridine kinase activity
Mlg_1950	COG0779	Required for maturation of 30S ribosomal subunits
Mlg_1952	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mlg_1952	COG0116	Belongs to the methyltransferase superfamily
Mlg_1955	COG0564	pseudouridine synthase activity
Mlg_1957	COG1007	ATP synthesis coupled electron transport
Mlg_1960	COG0713	ATP synthesis coupled electron transport
Mlg_1962	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mlg_1963	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Mlg_1964	COG1034	ATP synthesis coupled electron transport
Mlg_1967	COG0649	NAD binding
Mlg_1968	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mlg_1969	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mlg_1970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mlg_1971	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Mlg_1972	COG0149	triose-phosphate isomerase activity
Mlg_1973	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mlg_1974	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Mlg_1975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mlg_1976	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Mlg_1980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mlg_1982	COG0505	Belongs to the CarA family
Mlg_1983	COG1131	(ABC) transporter
Mlg_1984	COG0842	Transport permease protein
Mlg_1988	COG0259	pyridoxamine-phosphate oxidase activity
Mlg_1990	COG1011	Hydrolase
Mlg_1991	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Mlg_1992	COG0328	RNA-DNA hybrid ribonuclease activity
Mlg_1994	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mlg_1995	COG1388	LysM domain
Mlg_1995	COG0741	lytic transglycosylase activity
Mlg_1996	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Mlg_1997	COG2894	cell division
Mlg_1998	COG0850	regulation of cytokinetic process
Mlg_2003	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mlg_2006	COG2176	DNA-directed DNA polymerase activity
Mlg_2006	COG5002	protein histidine kinase activity
Mlg_2007	COG0326	Molecular chaperone. Has ATPase activity
Mlg_2009	COG4191	Histidine kinase
Mlg_2012	COG2204	response regulator
Mlg_2013	COG1024	Enoyl-CoA hydratase
Mlg_2013	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mlg_2015	COG0409	Hydrogenase expression formation protein
Mlg_2017	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Mlg_2019	COG0375	protein maturation
Mlg_2023	COG1773	rubredoxin
Mlg_2028	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Mlg_2030	COG4771	TonB-dependent receptor
Mlg_2033	COG0310	cobalt ion transport
Mlg_2035	COG1122	ATPase activity
Mlg_2037	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mlg_2038	COG0028	Belongs to the TPP enzyme family
Mlg_2039	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mlg_2041	COG3830	Belongs to the UPF0237 family
Mlg_2041	COG0560	Phosphoserine phosphatase
Mlg_2042	COG5001	Diguanylate cyclase
Mlg_2042	COG3300	MHYT domain
Mlg_2043	COG2204	response regulator
Mlg_2044	COG1294	oxidase, subunit
Mlg_2045	COG1271	oxidase subunit
Mlg_2046	COG0730	response to heat
Mlg_2050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mlg_2053	COG5002	protein histidine kinase activity
Mlg_2053	COG2176	DNA-directed DNA polymerase activity
Mlg_2058	COG3938	Belongs to the proline racemase family
Mlg_2062	COG0668	transmembrane transport
Mlg_2063	COG0309	Hydrogenase expression formation protein (HypE)
Mlg_2065	COG1720	tRNA m6t6A37 methyltransferase activity
Mlg_2066	COG5001	Diguanylate cyclase
Mlg_2067	COG0352	thiamine-phosphate diphosphorylase activity
Mlg_2068	COG1773	rubredoxin
Mlg_2074	COG0516	GMP reductase activity
Mlg_2074	COG0517	IMP dehydrogenase activity
Mlg_2077	COG2199	diguanylate cyclase activity
Mlg_2082	COG0237	dephospho-CoA kinase activity
Mlg_2083	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Mlg_2084	COG0494	nUDIX hydrolase
Mlg_2085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mlg_2086	COG0653	protein targeting
Mlg_2089	COG1830	Aldolase
Mlg_2091	COG2111	Na H antiporter
Mlg_2094	COG1863	multisubunit Na H antiporter MnhE subunit
Mlg_2095	COG2212	antiporter activity
Mlg_2098	COG0488	(ABC) transporter
Mlg_2099	COG0788	formyltetrahydrofolate deformylase activity
Mlg_2102	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Mlg_2102	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mlg_2103	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Mlg_2104	COG0583	DNA-binding transcription factor activity
Mlg_2105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Mlg_2108	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlg_2110	COG0183	Belongs to the thiolase family
Mlg_2113	COG2067	long-chain fatty acid transport protein
Mlg_2114	COG0175	sulfate reduction
Mlg_2116	COG1845	cytochrome c oxidase, subunit III
Mlg_2119	COG0714	Associated with various cellular activities
Mlg_2123	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Mlg_2124	COG1960	acyl-CoA dehydrogenase activity
Mlg_2125	COG0183	Belongs to the thiolase family
Mlg_2126	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mlg_2126	COG1024	Enoyl-CoA hydratase
Mlg_2127	COG1022	Amp-dependent synthetase and ligase
Mlg_2128	COG1960	acyl-CoA dehydrogenase activity
Mlg_2129	COG1309	transcriptional regulator
Mlg_2133	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mlg_2137	COG1063	alcohol dehydrogenase
Mlg_2139	COG1126	abc transporter atp-binding protein
Mlg_2140	COG0765	amino acid transport
Mlg_2141	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Mlg_2142	COG2135	peptidase activity
Mlg_2147	COG0577	efflux transmembrane transporter activity
Mlg_2147	COG1136	(ABC) transporter
Mlg_2148	COG0577	efflux transmembrane transporter activity
Mlg_2148	COG1136	(ABC) transporter
Mlg_2151	COG2204	response regulator
Mlg_2152	COG4191	Histidine kinase
Mlg_2153	COG4566	intracellular signal transduction
Mlg_2162	COG4964	Belongs to the GSP D family
Mlg_2166	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mlg_2167	COG2274	protein secretion by the type I secretion system
Mlg_2170	COG2885	chlorophyll binding
Mlg_2170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Mlg_2171	COG5001	Diguanylate cyclase
Mlg_2174	COG1739	Uncharacterized protein family UPF0029
Mlg_2176	COG4608	Belongs to the ABC transporter superfamily
Mlg_2177	COG0444	Belongs to the ABC transporter superfamily
Mlg_2184	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mlg_2185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mlg_2186	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Mlg_2189	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Mlg_2190	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mlg_2191	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Mlg_2192	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Mlg_2193	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Mlg_2194	COG0772	Belongs to the SEDS family
Mlg_2195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Mlg_2196	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mlg_2197	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Mlg_2198	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Mlg_2201	COG0275	rRNA processing
Mlg_2202	COG2001	Belongs to the MraZ family
Mlg_2203	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Mlg_2205	COG0792	nuclease activity
Mlg_2206	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Mlg_2207	COG2969	positive regulation of protein catabolic process
Mlg_2208	COG0625	glutathione transferase activity
Mlg_2209	COG2857	Cytochrome c1
Mlg_2210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mlg_2211	COG0723	plastoquinol--plastocyanin reductase activity
Mlg_2214	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mlg_2216	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mlg_2217	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Mlg_2221	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Mlg_2222	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Mlg_2223	COG1127	ABC transporter
Mlg_2224	COG0530	calcium, potassium:sodium antiporter activity
Mlg_2226	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Mlg_2228	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Mlg_2229	COG1137	ATPase activity
Mlg_2233	COG1660	Displays ATPase and GTPase activities
Mlg_2236	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Mlg_2237	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mlg_2239	COG3243	poly(R)-hydroxyalkanoic acid synthase
Mlg_2240	COG0742	ribosomal rna small subunit methyltransferase
Mlg_2241	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Mlg_2242	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mlg_2244	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Mlg_2245	COG1765	OsmC-like protein
Mlg_2247	COG0134	indole-3-glycerol-phosphate synthase activity
Mlg_2248	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mlg_2251	COG0546	phosphoglycolate phosphatase activity
Mlg_2252	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Mlg_2254	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mlg_2256	COG0415	Belongs to the DNA photolyase family
Mlg_2257	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mlg_2259	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mlg_2260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Mlg_2261	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Mlg_2262	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Mlg_2263	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mlg_2265	COG0189	ligase activity
Mlg_2265	COG4067	protein conserved in archaea
Mlg_2266	COG0189	ligase activity
Mlg_2269	COG4172	Belongs to the ABC transporter superfamily
Mlg_2270	COG4239	(ABC) transporter, permease
Mlg_2271	COG4174	ABC transporter (Permease)
Mlg_2274	COG4166	transmembrane transport
Mlg_2276	COG4771	TonB-dependent receptor
Mlg_2279	COG1620	l-lactate permease
Mlg_2281	COG1139	Iron-sulfur cluster binding protein
Mlg_2282	COG0247	lactate metabolic process
Mlg_2283	COG2186	Transcriptional regulator
Mlg_2284	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mlg_2287	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Mlg_2288	COG0740	serine-type endopeptidase activity
Mlg_2289	COG0544	peptidyl-prolyl cis-trans isomerase activity
Mlg_2296	COG4942	peptidase
Mlg_2301	COG3550	peptidyl-serine autophosphorylation
Mlg_2313	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mlg_2314	COG1196	nuclear chromosome segregation
Mlg_2317	COG1088	dTDP-glucose 4,6-dehydratase activity
Mlg_2318	COG1091	dTDP-4-dehydrorhamnose reductase activity
Mlg_2321	COG1132	(ABC) transporter
Mlg_2322	COG1086	Polysaccharide biosynthesis protein
Mlg_2323	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Mlg_2324	COG1083	cytidylyl-transferase
Mlg_2327	COG2089	acid synthase
Mlg_2342	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mlg_2344	COG0175	sulfate reduction
Mlg_2347	COG0471	metal ion transport
Mlg_2347	COG3273	potassium ion transport
Mlg_2349	COG1686	Belongs to the peptidase S11 family
Mlg_2353	COG1215	transferase activity, transferring glycosyl groups
Mlg_2355	COG1132	(ABC) transporter
Mlg_2357	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mlg_2359	COG4638	Rieske (2fe-2S)
Mlg_2361	COG1012	belongs to the aldehyde dehydrogenase family
Mlg_2362	COG0473	3-isopropylmalate dehydrogenase activity
Mlg_2365	COG0438	transferase activity, transferring glycosyl groups
Mlg_2366	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Mlg_2369	COG2089	acid synthase
Mlg_2377	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mlg_2378	COG0280	phosphate acetyltransferase
Mlg_2379	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Mlg_2380	COG3243	poly(R)-hydroxyalkanoic acid synthase
Mlg_2386	COG3156	type II secretion system protein K
Mlg_2392	COG1459	type II secretion system
Mlg_2403	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mlg_2407	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Mlg_2408	COG4181	ATPase activity
Mlg_2410	COG2974	May be involved in recombination
Mlg_2411	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Mlg_2415	COG1047	Peptidyl-prolyl cis-trans
Mlg_2417	COG3360	Dodecin
Mlg_2419	COG3065	identical protein binding
Mlg_2421	COG0288	reversible hydration of carbon dioxide
Mlg_2424	COG0488	(ABC) transporter
Mlg_2426	COG0243	molybdopterin cofactor binding
Mlg_2427	COG0437	4 iron, 4 sulfur cluster binding
Mlg_2433	COG2226	methyltransferase
Mlg_2435	COG0156	8-amino-7-oxononanoate synthase activity
Mlg_2436	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Mlg_2437	COG1040	competence protein
Mlg_2438	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Mlg_2439	COG3161	chorismate lyase activity
Mlg_2440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Mlg_2442	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Mlg_2443	COG1758	RNA polymerase activity
Mlg_2444	COG0194	GDP metabolic process
Mlg_2445	COG1561	YicC-like family, N-terminal region
Mlg_2446	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Mlg_2447	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mlg_2448	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mlg_2453	COG0154	amidase activity
Mlg_2457	COG0316	Belongs to the HesB IscA family
Mlg_2457	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Mlg_2461	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Mlg_2462	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlg_2463	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Mlg_2464	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Mlg_2464	COG0678	peroxiredoxin activity
Mlg_2467	COG2409	Drug exporters of the RND superfamily
Mlg_2473	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Mlg_2474	COG0047	phosphoribosylformylglycinamidine synthase activity
Mlg_2474	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mlg_2475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Mlg_2476	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mlg_2480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Mlg_2481	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Mlg_2483	COG4783	chaperone-mediated protein folding
Mlg_2485	COG3243	poly(R)-hydroxyalkanoic acid synthase
Mlg_2486	COG1028	Short-chain dehydrogenase reductase Sdr
Mlg_2490	COG0318	PFAM AMP-dependent synthetase and ligase
Mlg_2492	COG0217	transcriptional regulatory protein
Mlg_2493	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Mlg_2494	COG0632	four-way junction helicase activity
Mlg_2496	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Mlg_2499	COG2210	Belongs to the sulfur carrier protein TusA family
Mlg_2500	COG0425	Belongs to the sulfur carrier protein TusA family
Mlg_2504	COG0642	Histidine kinase
Mlg_2510	COG0429	hydrolase of the alpha beta-hydrolase fold
Mlg_2511	COG5002	protein histidine kinase activity
Mlg_2511	COG5001	Diguanylate cyclase
Mlg_2511	COG3447	MASE1 domain protein
Mlg_2513	COG3383	formate dehydrogenase (NAD+) activity
Mlg_2515	COG0346	lactoylglutathione lyase activity
Mlg_2516	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mlg_2517	COG0358	DNA primase activity
Mlg_2518	COG1610	YqeY-like protein
Mlg_2519	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Mlg_2520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mlg_2521	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Mlg_2522	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Mlg_2523	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Mlg_2526	COG1515	deoxyribonuclease V activity
Mlg_2529	COG2885	chlorophyll binding
Mlg_2529	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Mlg_2530	COG0543	2 iron, 2 sulfur cluster binding
Mlg_2530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Mlg_2531	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Mlg_2532	COG1943	Transposase
Mlg_2533	COG0339	signal peptide processing
Mlg_2534	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mlg_2535	COG2945	thiolester hydrolase activity
Mlg_2538	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Mlg_2541	COG3079	Belongs to the UPF0149 family
Mlg_2542	COG0006	proline dipeptidase activity
Mlg_2543	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Mlg_2544	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Mlg_2547	COG0045	succinate-CoA ligase (ADP-forming) activity
Mlg_2548	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Mlg_2549	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mlg_2549	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Mlg_2558	COG0542	response to heat
Mlg_2564	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Mlg_2565	COG2084	Dehydrogenase
Mlg_2566	COG0693	protein deglycase activity
Mlg_2567	COG2861	carbohydrate metabolic process
Mlg_2568	COG0793	Belongs to the peptidase S41A family
Mlg_2569	COG4942	peptidase
Mlg_2571	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Mlg_2572	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Mlg_2573	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Mlg_2575	COG1178	ABC-type Fe3 transport system permease component
Mlg_2576	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mlg_2577	COG0509	glycine decarboxylation via glycine cleavage system
Mlg_2578	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mlg_2579	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Mlg_2580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mlg_2584	COG0543	2 iron, 2 sulfur cluster binding
Mlg_2584	COG0493	'glutamate synthase
Mlg_2586	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Mlg_2587	COG1116	anion transmembrane transporter activity
Mlg_2588	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mlg_2589	COG1116	anion transmembrane transporter activity
Mlg_2589	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mlg_2591	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Mlg_2593	COG0523	cobalamin synthesis protein
Mlg_2596	COG0022	dehydrogenase e1 component
Mlg_2596	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mlg_2597	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlg_2601	COG2079	MmgE PrpD family protein
Mlg_2603	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Mlg_2604	COG0372	Belongs to the citrate synthase family
Mlg_2605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Mlg_2606	COG0604	alcohol dehydrogenase
Mlg_2611	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mlg_2612	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mlg_2613	COG0140	phosphoribosyl-ATP diphosphatase activity
Mlg_2614	COG0107	imidazoleglycerol-phosphate synthase activity
Mlg_2615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mlg_2616	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mlg_2617	COG0131	Imidazoleglycerol-phosphate dehydratase
Mlg_2618	COG1490	D-aminoacyl-tRNA deacylase activity
Mlg_2620	COG1560	Kdo2-lipid A biosynthetic process
Mlg_2622	COG0569	domain protein
Mlg_2623	COG2204	response regulator
Mlg_2624	COG5000	phosphorelay sensor kinase activity
Mlg_2627	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mlg_2628	COG0242	peptide deformylase activity
Mlg_2630	COG0758	DNA mediated transformation
Mlg_2631	COG2922	Belongs to the Smg family
Mlg_2632	COG1754	DNA topoisomerase type I activity
Mlg_2632	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mlg_2633	COG0009	L-threonylcarbamoyladenylate synthase
Mlg_2634	COG0408	coproporphyrinogen oxidase activity
Mlg_2636	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Mlg_2638	COG1560	Kdo2-lipid A biosynthetic process
Mlg_2639	COG1538	Outer membrane efflux protein
Mlg_2640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mlg_2641	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Mlg_2642	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Mlg_2649	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Mlg_2650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlg_2653	COG3706	GGDEF domain
Mlg_2654	COG0405	Gamma-glutamyltransferase
Mlg_2655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Mlg_2656	COG0742	ribosomal rna small subunit methyltransferase
Mlg_2657	COG0612	Peptidase, M16
Mlg_2658	COG0612	Peptidase, M16
Mlg_2659	COG0552	protein localization to endoplasmic reticulum
Mlg_2660	COG2884	Cell division ATP-binding protein ftsE
Mlg_2661	COG2177	Part of the ABC transporter FtsEX involved in
Mlg_2664	COG2003	Belongs to the UPF0758 family
Mlg_2665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Mlg_2670	COG0181	hydroxymethylbilane synthase activity
Mlg_2672	COG3275	phosphorelay sensor kinase activity
Mlg_2673	COG0165	Argininosuccinate lyase
Mlg_2674	COG0517	IMP dehydrogenase activity
Mlg_2676	COG1278	Cold shock
Mlg_2689	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mlg_2690	COG1562	ergosterol biosynthetic process
Mlg_2692	COG2226	methyltransferase
Mlg_2694	COG2982	Protein involved in outer membrane biogenesis
Mlg_2695	COG1194	a g-specific adenine glycosylase
Mlg_2696	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Mlg_2697	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mlg_2698	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Mlg_2706	COG0183	Belongs to the thiolase family
Mlg_2707	COG0589	response to stress
Mlg_2709	COG0798	PFAM Bile acid sodium symporter
Mlg_2712	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mlg_2713	COG0640	Transcriptional regulator
Mlg_2719	COG0659	secondary active sulfate transmembrane transporter activity
Mlg_2721	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mlg_2722	COG2197	response regulator
Mlg_2723	COG3851	Histidine kinase
Mlg_2724	COG4772	TonB-dependent receptor
Mlg_2726	COG1012	belongs to the aldehyde dehydrogenase family
Mlg_2728	COG4772	TonB-dependent receptor
Mlg_2736	COG3284	Transcriptional regulator
Mlg_2737	COG2133	pyrroloquinoline quinone binding
Mlg_2739	COG1122	ATPase activity
Mlg_2746	COG0629	single-stranded DNA binding
Mlg_2747	COG2814	Major facilitator Superfamily
Mlg_2748	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mlg_2749	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mlg_2751	COG0254	rRNA binding
Mlg_2752	COG0372	Belongs to the citrate synthase family
Mlg_2761	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Mlg_2762	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Mlg_2763	COG0067	glutamate synthase
Mlg_2763	COG0069	glutamate synthase activity
Mlg_2763	COG0070	glutamate synthase
Mlg_2764	COG0493	'glutamate synthase
Mlg_2765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Mlg_2769	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Mlg_2770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Mlg_2771	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Mlg_2774	COG0018	arginyl-trna synthetase
Mlg_2775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mlg_2777	COG2255	four-way junction helicase activity
Mlg_2778	COG0235	Class ii aldolase
Mlg_2779	COG2902	Dehydrogenase
Mlg_2781	COG0596	Alpha beta hydrolase
Mlg_2782	COG0708	Exodeoxyribonuclease III
Mlg_2784	COG0668	transmembrane transport
Mlg_2788	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mlg_2789	COG1802	Transcriptional regulator
Mlg_2790	COG0318	PFAM AMP-dependent synthetase and ligase
Mlg_2792	COG0859	PFAM glycosyl transferase family 9
Mlg_2793	COG0438	transferase activity, transferring glycosyl groups
Mlg_2794	COG0515	serine threonine protein kinase
Mlg_2802	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mlg_2803	COG1132	(ABC) transporter
Mlg_2805	COG1560	Kdo2-lipid A biosynthetic process
Mlg_2806	COG0859	PFAM glycosyl transferase family 9
Mlg_2809	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mlg_2810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mlg_2810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mlg_2811	COG2030	dehydratase
Mlg_2812	COG1492	cobalamin metabolic process
Mlg_2813	COG1797	cobyrinic acid a,c-diamide synthase activity
Mlg_2815	COG4206	TonB-dependent receptor
Mlg_2816	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Mlg_2820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Mlg_2821	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mlg_2822	COG1120	ATPase activity
Mlg_2825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mlg_2826	COG0306	phosphate transporter
Mlg_2827	COG1392	Phosphate transport regulator
Mlg_2831	COG1360	Flagellar Motor Protein
Mlg_2833	COG3954	Phosphoribulokinase
Mlg_2834	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Mlg_2836	COG1850	ribulose-bisphosphate carboxylase activity
Mlg_2840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Mlg_2841	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Mlg_2842	COG0126	phosphoglycerate kinase activity
Mlg_2843	COG0469	pyruvate kinase activity
Mlg_2846	COG0756	dUTP diphosphatase activity
Mlg_2847	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mlg_2848	COG0733	neurotransmitter:sodium symporter activity
Mlg_2851	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Mlg_2852	COG1333	cytochrome c biogenesis protein
Mlg_2855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mlg_2856	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Mlg_2857	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Mlg_2859	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Mlg_2863	COG0210	DNA helicase
Mlg_2864	COG0583	DNA-binding transcription factor activity
Mlg_2867	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mlg_2868	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Mlg_2869	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Mlg_2870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Mlg_2871	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Mlg_2872	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mlg_2873	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Mlg_2875	COG0356	it plays a direct role in the translocation of protons across the membrane
Mlg_2877	COG1475	DNA binding
Mlg_2878	COG1192	Involved in chromosome partitioning
Mlg_2879	COG0357	Ribosomal RNA small subunit methyltransferase G
Mlg_2880	COG0445	tRNA wobble uridine modification
Mlg_2881	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mlg_2882	COG0706	membrane insertase activity
Mlg_2883	COG0594	ribonuclease P activity
Mlg_2884	COG0230	Belongs to the bacterial ribosomal protein bL34 family