locus-tag	class	description
NNL22_00005	COG0706	membrane insertase activity
NNL22_00010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NNL22_00015	COG0594	ribonuclease P activity
NNL22_00025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NNL22_00030	COG0592	DNA-directed DNA polymerase activity
NNL22_00060	COG3448	diguanylate cyclase activity
NNL22_00060	COG4175	Glycine betaine
NNL22_00065	COG4176	ABC-type proline glycine betaine transport system permease component
NNL22_00075	COG1560	Kdo2-lipid A biosynthetic process
NNL22_00080	COG0751	glycine-tRNA ligase activity
NNL22_00085	COG0752	glycyl-tRNA synthetase alpha subunit
NNL22_00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NNL22_00110	COG0569	domain protein
NNL22_00120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NNL22_00125	COG0242	peptide deformylase activity
NNL22_00135	COG0758	DNA mediated transformation
NNL22_00140	COG0009	L-threonylcarbamoyladenylate synthase
NNL22_00150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NNL22_00155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NNL22_00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NNL22_00175	COG0339	signal peptide processing
NNL22_00190	COG0534	Mate efflux family protein
NNL22_00230	COG1612	heme a metabolic process
NNL22_00235	COG0109	protoheme IX farnesyltransferase activity
NNL22_00240	COG0784	Response regulator, receiver
NNL22_00240	COG4191	Histidine kinase
NNL22_00305	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NNL22_00315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NNL22_00330	COG2205	protein histidine kinase activity
NNL22_00330	COG5002	protein histidine kinase activity
NNL22_00330	COG0784	Response regulator, receiver
NNL22_00380	COG3409	Peptidoglycan-binding domain 1 protein
NNL22_00380	COG3773	Cell wall hydrolase
NNL22_00395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NNL22_00400	COG0602	queuosine metabolic process
NNL22_00430	COG0668	transmembrane transport
NNL22_00440	COG3706	GGDEF domain
NNL22_00455	COG2195	Cleaves the N-terminal amino acid of tripeptides
NNL22_00470	COG0583	DNA-binding transcription factor activity
NNL22_00505	COG0318	PFAM AMP-dependent synthetase and ligase
NNL22_00515	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NNL22_00525	COG0513	Belongs to the DEAD box helicase family
NNL22_00530	COG0784	Response regulator, receiver
NNL22_00530	COG5002	protein histidine kinase activity
NNL22_00530	COG2205	protein histidine kinase activity
NNL22_00535	COG0017	Asparaginyl-tRNA synthetase
NNL22_00555	COG0545	Peptidyl-prolyl cis-trans isomerase
NNL22_00590	COG0583	DNA-binding transcription factor activity
NNL22_00595	COG4608	Belongs to the ABC transporter superfamily
NNL22_00600	COG0444	Belongs to the ABC transporter superfamily
NNL22_00605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNL22_00610	COG0601	transmembrane transport
NNL22_00615	COG0601	transmembrane transport
NNL22_00620	COG0747	negative chemotaxis
NNL22_00630	COG0579	oxidoreductase
NNL22_00655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNL22_00680	COG2354	Protein conserved in bacteria
NNL22_00690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NNL22_00700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNL22_00730	COG2832	Protein of unknown function (DUF454)
NNL22_00745	COG3530	Putative quorum-sensing-regulated virulence factor
NNL22_00770	COG0545	Peptidyl-prolyl cis-trans isomerase
NNL22_00780	COG0741	lytic transglycosylase activity
NNL22_00785	COG1739	Uncharacterized protein family UPF0029
NNL22_00790	COG4206	TonB-dependent receptor
NNL22_00805	COG1942	4-Oxalocrotonate Tautomerase
NNL22_00810	COG0477	Major facilitator Superfamily
NNL22_00815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NNL22_00815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NNL22_00830	COG0745	RESPONSE REGULATOR receiver
NNL22_00835	COG5002	protein histidine kinase activity
NNL22_00845	COG0730	response to heat
NNL22_00865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NNL22_00880	COG3850	Histidine kinase
NNL22_00880	COG3437	response regulator, receiver
NNL22_00880	COG4999	Histidine kinase
NNL22_00880	COG2205	protein histidine kinase activity
NNL22_00890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NNL22_00895	COG4221	oxidoreductase activity
NNL22_00905	COG0033	Phosphoglucomutase
NNL22_00915	COG3122	Protein conserved in bacteria
NNL22_00940	COG0789	Transcriptional regulator
NNL22_00975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NNL22_00980	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_00980	COG1024	Enoyl-CoA hydratase
NNL22_01035	COG1278	Cold shock
NNL22_01060	COG3123	guanosine phosphorylase activity
NNL22_01065	COG1278	Cold shock
NNL22_01070	COG3647	Membrane
NNL22_01090	COG0596	Alpha beta hydrolase
NNL22_01120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NNL22_01125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NNL22_01130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NNL22_01135	COG2204	response regulator
NNL22_01150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NNL22_01160	COG0302	gtp cyclohydrolase
NNL22_01170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NNL22_01175	COG1126	abc transporter atp-binding protein
NNL22_01180	COG0765	amino acid transport
NNL22_01185	COG4597	amino acid ABC transporter
NNL22_01190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNL22_01200	COG3148	PFAM DTW domain containing protein
NNL22_01210	COG0517	IMP dehydrogenase activity
NNL22_01210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NNL22_01210	COG0617	tRNA 3'-terminal CCA addition
NNL22_01230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NNL22_01240	COG1960	acyl-CoA dehydrogenase activity
NNL22_01250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NNL22_01260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NNL22_01285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNL22_01300	COG1477	protein flavinylation
NNL22_01310	COG1166	arginine decarboxylase activity
NNL22_01315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NNL22_01325	COG0004	ammonium transporteR
NNL22_01330	COG0347	Belongs to the P(II) protein family
NNL22_01335	COG2960	long-chain fatty acid transporting porin activity
NNL22_01340	COG0606	chelatase, subunit chli
NNL22_01345	COG1116	anion transmembrane transporter activity
NNL22_01355	COG1116	anion transmembrane transporter activity
NNL22_01355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NNL22_01365	COG0590	tRNA wobble adenosine to inosine editing
NNL22_01370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NNL22_01380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NNL22_01385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NNL22_01395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NNL22_01395	COG2813	Specifically methylates the guanine in position
NNL22_01400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NNL22_01405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NNL22_01445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NNL22_01450	COG0826	peptidase U32
NNL22_01470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NNL22_01480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NNL22_01485	COG1561	YicC-like family, N-terminal region
NNL22_01490	COG3550	peptidyl-serine autophosphorylation
NNL22_01495	COG3620	sequence-specific DNA binding
NNL22_01500	COG1024	Enoyl-CoA hydratase
NNL22_01505	COG1902	pentaerythritol trinitrate reductase activity
NNL22_01505	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNL22_01510	COG1309	transcriptional regulator
NNL22_01545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNL22_01550	COG0628	permease
NNL22_01560	COG1758	RNA polymerase activity
NNL22_01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NNL22_01580	COG0583	DNA-binding transcription factor activity
NNL22_01585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NNL22_01600	COG1858	cytochrome C peroxidase
NNL22_01690	COG0358	DNA primase activity
NNL22_01695	COG1610	YqeY-like protein
NNL22_01700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NNL22_01705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NNL22_01710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NNL22_01715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NNL22_01720	COG0302	gtp cyclohydrolase
NNL22_01720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NNL22_01725	COG0166	Belongs to the GPI family
NNL22_01730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NNL22_01735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NNL22_01740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NNL22_01755	COG4191	Histidine kinase
NNL22_01760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NNL22_01765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NNL22_01770	COG1489	DNA binding
NNL22_01800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NNL22_01810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NNL22_01815	COG0352	thiamine-phosphate diphosphorylase activity
NNL22_01820	COG0351	phosphomethylpyrimidine kinase
NNL22_01820	COG0352	thiamine-phosphate diphosphorylase activity
NNL22_01825	COG1981	membrane
NNL22_01835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NNL22_01850	COG0316	Belongs to the HesB IscA family
NNL22_01855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NNL22_01860	COG0739	heme binding
NNL22_01865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NNL22_01915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NNL22_01915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NNL22_01920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NNL22_01965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NNL22_01970	COG0081	regulation of translation
NNL22_01975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NNL22_01980	COG0222	ribosome binding
NNL22_01985	COG0085	RNA polymerase activity
NNL22_01990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NNL22_01995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NNL22_02000	COG0049	tRNA binding
NNL22_02005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NNL22_02010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NNL22_02015	COG0051	transcription antitermination factor activity, RNA binding
NNL22_02020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NNL22_02025	COG0088	Forms part of the polypeptide exit tunnel
NNL22_02030	COG0089	rRNA binding
NNL22_02035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NNL22_02040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NNL22_02045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NNL22_02050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NNL22_02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NNL22_02060	COG0255	Belongs to the universal ribosomal protein uL29 family
NNL22_02065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NNL22_02070	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NNL22_02075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NNL22_02080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NNL22_02085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NNL22_02090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NNL22_02095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NNL22_02100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NNL22_02105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NNL22_02110	COG1841	ribosomal large subunit assembly
NNL22_02115	COG0200	Binds to the 23S rRNA
NNL22_02125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NNL22_02130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NNL22_02135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NNL22_02140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NNL22_02145	COG0202	RNA polymerase activity
NNL22_02150	COG0203	ribosomal protein L17
NNL22_02160	COG2814	Major facilitator Superfamily
NNL22_02165	COG0629	single-stranded DNA binding
NNL22_02170	COG0840	transmembrane signaling receptor activity
NNL22_02175	COG0527	aspartate kinase activity
NNL22_02180	COG1917	Cupin 2, conserved barrel domain protein
NNL22_02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NNL22_02230	COG3267	Type II secretory pathway component ExeA
NNL22_02230	COG3409	Peptidoglycan-binding domain 1 protein
NNL22_02240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NNL22_02245	COG1459	type II secretion system
NNL22_02285	COG5183	chlorophyll binding
NNL22_02285	COG2133	pyrroloquinoline quinone binding
NNL22_02295	COG3852	Histidine kinase
NNL22_02305	COG0174	glutamine synthetase
NNL22_02310	COG1217	gtp-binding protein TYPA
NNL22_02320	COG1490	D-aminoacyl-tRNA deacylase activity
NNL22_02360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NNL22_02365	COG2203	Gaf domain
NNL22_02365	COG3706	GGDEF domain
NNL22_02365	COG4251	negative regulation of phosphorylation
NNL22_02365	COG5001	Diguanylate cyclase
NNL22_02385	COG0131	Imidazoleglycerol-phosphate dehydratase
NNL22_02390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NNL22_02395	COG0107	imidazoleglycerol-phosphate synthase activity
NNL22_02405	COG2861	carbohydrate metabolic process
NNL22_02415	COG4942	peptidase
NNL22_02420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NNL22_02425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NNL22_02435	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NNL22_02440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NNL22_02445	COG0183	Belongs to the thiolase family
NNL22_02450	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_02455	COG0617	tRNA 3'-terminal CCA addition
NNL22_02470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NNL22_02480	COG0748	coenzyme F420 binding
NNL22_02485	COG1960	acyl-CoA dehydrogenase activity
NNL22_02500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NNL22_02505	COG2233	PERMEase
NNL22_02510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NNL22_02525	COG1492	cobalamin metabolic process
NNL22_02530	COG2906	2 iron, 2 sulfur cluster binding
NNL22_02540	COG2193	ferroxidase activity
NNL22_02555	COG1040	competence protein
NNL22_02560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NNL22_02565	COG0156	8-amino-7-oxononanoate synthase activity
NNL22_02570	COG1073	alpha beta
NNL22_02570	COG2226	methyltransferase
NNL22_02575	COG1073	alpha beta
NNL22_02575	COG2226	methyltransferase
NNL22_02580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NNL22_02595	COG1960	acyl-CoA dehydrogenase activity
NNL22_02600	COG1960	acyl-CoA dehydrogenase activity
NNL22_02615	COG1466	dna polymerase III delta subunit
NNL22_02620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NNL22_02625	COG0495	leucyl-tRNA aminoacylation
NNL22_02640	COG4535	Mg2 and Co2 transporter CorC
NNL22_02645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NNL22_02650	COG1702	phosphate starvation-inducible protein PhoH
NNL22_02665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NNL22_02670	COG0583	DNA-binding transcription factor activity
NNL22_02675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NNL22_02680	COG0513	Belongs to the DEAD box helicase family
NNL22_02685	COG0534	Mate efflux family protein
NNL22_02695	COG0596	Alpha beta hydrolase
NNL22_02700	COG2203	Gaf domain
NNL22_02700	COG3706	GGDEF domain
NNL22_02700	COG4251	negative regulation of phosphorylation
NNL22_02700	COG5001	Diguanylate cyclase
NNL22_02705	COG3769	mannosylglycerate metabolic process
NNL22_02710	COG1215	transferase activity, transferring glycosyl groups
NNL22_02715	COG0366	Alpha amylase catalytic
NNL22_02730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNL22_02740	COG3081	Nucleoid-associated protein
NNL22_02750	COG0175	sulfate reduction
NNL22_02765	COG4399	Belongs to the UPF0754 family
NNL22_02800	COG5002	protein histidine kinase activity
NNL22_02800	COG2205	protein histidine kinase activity
NNL22_02800	COG0784	Response regulator, receiver
NNL22_02810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NNL22_02815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NNL22_02820	COG3956	TIGRFAM MazG family protein
NNL22_02825	COG0028	Belongs to the TPP enzyme family
NNL22_02840	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_02860	COG5001	Diguanylate cyclase
NNL22_02860	COG5002	protein histidine kinase activity
NNL22_02865	COG0784	Response regulator, receiver
NNL22_02870	COG4251	negative regulation of phosphorylation
NNL22_02890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NNL22_02900	COG0563	adenylate kinase activity
NNL22_02905	COG1214	PFAM Peptidase M22, glycoprotease
NNL22_02910	COG1968	undecaprenyl-diphosphatase activity
NNL22_02920	COG0742	ribosomal rna small subunit methyltransferase
NNL22_02925	COG2937	Belongs to the GPAT DAPAT family
NNL22_02930	COG1131	(ABC) transporter
NNL22_02945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NNL22_02970	COG4191	Histidine kinase
NNL22_02980	COG3458	cephalosporin-C deacetylase activity
NNL22_02990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNL22_03005	COG0583	DNA-binding transcription factor activity
NNL22_03010	COG1960	acyl-CoA dehydrogenase activity
NNL22_03015	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_03030	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_03040	COG0587	DNA-directed DNA polymerase activity
NNL22_03060	COG2205	protein histidine kinase activity
NNL22_03060	COG2198	Histidine kinase
NNL22_03060	COG0784	Response regulator, receiver
NNL22_03070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNL22_03075	COG2153	protein acetylation
NNL22_03085	COG2176	DNA-directed DNA polymerase activity
NNL22_03095	COG2840	Smr protein MutS2
NNL22_03105	COG0235	Class ii aldolase
NNL22_03110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NNL22_03115	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NNL22_03145	COG0631	protein serine/threonine phosphatase activity
NNL22_03190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NNL22_03205	COG1393	Belongs to the ArsC family
NNL22_03210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNL22_03225	COG0825	malonyl-CoA metabolic process
NNL22_03230	COG0037	tRNA processing
NNL22_03235	COG0504	CTP synthase activity
NNL22_03240	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NNL22_03245	COG0148	phosphopyruvate hydratase activity
NNL22_03250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NNL22_03255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NNL22_03260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NNL22_03265	COG0585	pseudouridine synthase activity
NNL22_03270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NNL22_03275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NNL22_03310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NNL22_03320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NNL22_03325	COG4660	Part of a membrane complex involved in electron transport
NNL22_03335	COG4658	electron transport chain
NNL22_03340	COG4656	Part of a membrane complex involved in electron transport
NNL22_03345	COG2878	Part of a membrane complex involved in electron transport
NNL22_03350	COG4657	Part of a membrane complex involved in electron transport
NNL22_03355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NNL22_03355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NNL22_03360	COG0489	protein tyrosine kinase activity
NNL22_03370	COG0390	transport system, permease component
NNL22_03375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NNL22_03380	COG0717	Belongs to the dCTP deaminase family
NNL22_03385	COG2814	Major facilitator Superfamily
NNL22_03400	COG3977	Valine--pyruvate aminotransferase
NNL22_03405	COG3706	GGDEF domain
NNL22_03410	COG2226	methyltransferase
NNL22_03420	COG0534	Mate efflux family protein
NNL22_03435	COG1054	Belongs to the UPF0176 family
NNL22_03445	COG4191	Histidine kinase
NNL22_03460	COG2204	response regulator
NNL22_03470	COG1960	acyl-CoA dehydrogenase activity
NNL22_03510	COG0123	including yeast histone deacetylase and acetoin utilization protein
NNL22_03530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NNL22_03545	COG3706	GGDEF domain
NNL22_03550	COG2207	Transcriptional regulator
NNL22_03555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNL22_03560	COG2207	Transcriptional regulator
NNL22_03565	COG0277	FAD linked oxidase domain protein
NNL22_03570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NNL22_03575	COG1070	Carbohydrate kinase
NNL22_03580	COG0745	RESPONSE REGULATOR receiver
NNL22_03585	COG1666	GTP binding
NNL22_03590	COG2211	Major facilitator Superfamily
NNL22_03600	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_03605	COG3030	protein affecting phage T7 exclusion by the F plasmid
NNL22_03610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NNL22_03615	COG0459	protein refolding
NNL22_03635	COG0501	Belongs to the peptidase M48B family
NNL22_03640	COG1704	LemA family
NNL22_03645	COG3300	MHYT domain
NNL22_03645	COG5001	Diguanylate cyclase
NNL22_03650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NNL22_03660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NNL22_03735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NNL22_03740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NNL22_03745	COG0705	Rhomboid family
NNL22_03760	COG0308	aminopeptidase N
NNL22_03780	COG2358	TRAP transporter, solute receptor (TAXI family
NNL22_03790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NNL22_03795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NNL22_03800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NNL22_03805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NNL22_03810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NNL22_03815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NNL22_03815	COG0072	phenylalanine-tRNA ligase activity
NNL22_03820	COG0776	regulation of translation
NNL22_03835	COG0625	glutathione transferase activity
NNL22_03840	COG0514	ATP-dependent DNA helicase (RecQ)
NNL22_03845	COG1322	Protein conserved in bacteria
NNL22_03850	COG5001	Diguanylate cyclase
NNL22_03850	COG5002	protein histidine kinase activity
NNL22_03865	COG0714	Associated with various cellular activities
NNL22_03885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NNL22_03885	COG1648	precorrin-2 dehydrogenase activity
NNL22_03890	COG0535	radical SAM domain protein
NNL22_03920	COG2010	Cytochrome c
NNL22_03945	COG2010	Cytochrome c
NNL22_03985	COG1639	'signal transduction protein
NNL22_04000	COG0300	oxidoreductase activity
NNL22_04005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNL22_04015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNL22_04025	COG5002	protein histidine kinase activity
NNL22_04045	COG0271	Belongs to the BolA IbaG family
NNL22_04050	COG0009	L-threonylcarbamoyladenylate synthase
NNL22_04115	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
NNL22_04130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NNL22_04150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NNL22_04160	COG1943	Transposase
NNL22_04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
NNL22_04170	COG0045	succinate-CoA ligase (ADP-forming) activity
NNL22_04170	COG1042	CoA-binding domain protein
NNL22_04170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNL22_04175	COG2974	May be involved in recombination
NNL22_04185	COG3022	response to hydroperoxide
NNL22_04200	COG2304	oxidoreductase activity
NNL22_04220	COG0714	Associated with various cellular activities
NNL22_04240	COG0442	prolyl-tRNA aminoacylation
NNL22_04245	COG1570	exodeoxyribonuclease VII activity
NNL22_04255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NNL22_04255	COG0519	Catalyzes the synthesis of GMP from XMP
NNL22_04295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NNL22_04300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NNL22_04305	COG0632	four-way junction helicase activity
NNL22_04310	COG2255	four-way junction helicase activity
NNL22_04315	COG0824	Thioesterase
NNL22_04335	COG0823	Involved in the tonB-independent uptake of proteins
NNL22_04335	COG5616	cAMP biosynthetic process
NNL22_04340	COG2885	chlorophyll binding
NNL22_04345	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NNL22_04360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NNL22_04370	COG0425	Belongs to the sulfur carrier protein TusA family
NNL22_04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NNL22_04390	COG2716	regulation of RNA biosynthetic process
NNL22_04395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNL22_04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NNL22_04500	COG0438	transferase activity, transferring glycosyl groups
NNL22_04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NNL22_04535	COG0631	protein serine/threonine phosphatase activity
NNL22_04540	COG0515	serine threonine protein kinase
NNL22_04540	COG2815	serine threonine protein kinase
NNL22_04545	COG1116	anion transmembrane transporter activity
NNL22_04545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NNL22_04550	COG4120	Belongs to the binding-protein-dependent transport system permease family
NNL22_04570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NNL22_04575	COG1840	ABC-type Fe3 transport system, periplasmic component
NNL22_04600	COG1131	(ABC) transporter
NNL22_04605	COG0842	Transport permease protein
NNL22_04610	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NNL22_04610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NNL22_04620	COG0778	Nitroreductase
NNL22_04625	COG1815	bacterial-type flagellum-dependent cell motility
NNL22_04635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NNL22_04645	COG4787	bacterial-type flagellum-dependent cell motility
NNL22_04655	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NNL22_04660	COG1706	bacterial-type flagellum-dependent cell motility
NNL22_04690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NNL22_04695	COG0343	queuine tRNA-ribosyltransferase activity
NNL22_04700	COG1862	Preprotein translocase
NNL22_04740	COG0105	UTP biosynthetic process
NNL22_04745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NNL22_04760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NNL22_04765	COG0124	histidyl-tRNA synthetase
NNL22_04770	COG2976	Protein conserved in bacteria
NNL22_04790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NNL22_04800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NNL22_04830	COG0784	Response regulator, receiver
NNL22_04830	COG0835	chemotaxis
NNL22_04835	COG0633	Ferredoxin
NNL22_04835	COG3217	Mosc domain protein beta barrel domain protein
NNL22_04845	COG0488	(ABC) transporter
NNL22_04855	COG0589	response to stress
NNL22_04870	COG1024	Enoyl-CoA hydratase
NNL22_04870	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_04875	COG0183	Belongs to the thiolase family
NNL22_04900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NNL22_04905	COG1053	succinate dehydrogenase
NNL22_04910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NNL22_04930	COG0045	succinate-CoA ligase (ADP-forming) activity
NNL22_04940	COG0180	Tryptophanyl-tRNA synthetase
NNL22_04950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NNL22_04970	COG1196	nuclear chromosome segregation
NNL22_04975	COG3115	cell septum assembly
NNL22_04980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NNL22_05000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNL22_05000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NNL22_05030	COG0784	Response regulator, receiver
NNL22_05030	COG0835	chemotaxis
NNL22_05035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NNL22_05045	COG1595	DNA-templated transcription, initiation
NNL22_05050	COG0415	Belongs to the DNA photolyase family
NNL22_05080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NNL22_05100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NNL22_05115	COG1960	acyl-CoA dehydrogenase activity
NNL22_05125	COG2204	response regulator
NNL22_05130	COG3437	response regulator, receiver
NNL22_05135	COG2205	protein histidine kinase activity
NNL22_05135	COG5002	protein histidine kinase activity
NNL22_05135	COG0784	Response regulator, receiver
NNL22_05145	COG0489	protein tyrosine kinase activity
NNL22_05160	COG1366	Belongs to the anti-sigma-factor antagonist family
NNL22_05165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NNL22_05170	COG1215	transferase activity, transferring glycosyl groups
NNL22_05195	COG0110	maltose O-acetyltransferase activity
NNL22_05235	COG2133	pyrroloquinoline quinone binding
NNL22_05245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NNL22_05255	COG0667	Aldo Keto reductase
NNL22_05260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NNL22_05265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NNL22_05270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NNL22_05275	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NNL22_05280	COG3100	YcgL domain-containing protein
NNL22_05285	COG2983	Belongs to the UPF0260 family
NNL22_05305	COG0121	glutamine amidotransferase
NNL22_05310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNL22_05315	COG0542	response to heat
NNL22_05350	COG0811	peptide transport
NNL22_05370	COG2030	dehydratase
NNL22_05375	COG2267	carboxylic ester hydrolase activity
NNL22_05380	COG0318	PFAM AMP-dependent synthetase and ligase
NNL22_05385	COG1643	Atp-dependent helicase
NNL22_05395	COG2853	Lipoprotein
NNL22_05420	COG1199	ATP-dependent helicase activity
NNL22_05425	COG2909	trisaccharide binding
NNL22_05430	COG0730	response to heat
NNL22_05515	COG0084	hydrolase, TatD family'
NNL22_05520	COG2267	carboxylic ester hydrolase activity
NNL22_05540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NNL22_05555	COG3243	poly(R)-hydroxyalkanoic acid synthase
NNL22_05565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NNL22_05570	COG0066	3-isopropylmalate dehydratase activity
NNL22_05575	COG0473	3-isopropylmalate dehydrogenase activity
NNL22_05595	COG0135	phosphoribosylanthranilate isomerase activity
NNL22_05605	COG0159	tryptophan synthase activity
NNL22_05610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NNL22_05615	COG0285	dihydrofolate synthase activity
NNL22_05625	COG1286	toxin biosynthetic process
NNL22_05640	COG1674	ftsk spoiiie
NNL22_05645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NNL22_05650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NNL22_05655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NNL22_05660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NNL22_05665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NNL22_05665	COG1648	precorrin-2 dehydrogenase activity
NNL22_05670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NNL22_05700	COG4172	Belongs to the ABC transporter superfamily
NNL22_05705	COG4239	(ABC) transporter, permease
NNL22_05710	COG4174	ABC transporter (Permease)
NNL22_05715	COG4166	transmembrane transport
NNL22_05720	COG4166	transmembrane transport
NNL22_05730	COG0741	lytic transglycosylase activity
NNL22_05730	COG1388	LysM domain
NNL22_05745	COG0328	RNA-DNA hybrid ribonuclease activity
NNL22_05770	COG0616	signal peptide processing
NNL22_05795	COG0316	Belongs to the HesB IscA family
NNL22_05795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NNL22_05800	COG4399	Belongs to the UPF0754 family
NNL22_05805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NNL22_05810	COG2920	part of a sulfur-relay system
NNL22_05815	COG2923	Belongs to the DsrF TusC family
NNL22_05820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NNL22_05850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NNL22_05875	COG1451	nucleotide metabolic process
NNL22_05890	COG1979	alcohol dehydrogenase
NNL22_05895	COG0784	Response regulator, receiver
NNL22_05895	COG5002	protein histidine kinase activity
NNL22_05895	COG2205	protein histidine kinase activity
NNL22_05910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NNL22_05920	COG2850	peptidyl-arginine hydroxylation
NNL22_05930	COG2915	High frequency lysogenization protein hflD homolog
NNL22_05935	COG0482	sulfurtransferase activity
NNL22_05945	COG1187	pseudouridine synthase activity
NNL22_05955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NNL22_05960	COG0542	response to heat
NNL22_05965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NNL22_05970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NNL22_05975	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NNL22_05980	COG0492	ferredoxin-NADP+ reductase activity
NNL22_05985	COG0714	Associated with various cellular activities
NNL22_06010	COG4591	ABC-type transport system involved in lipoprotein release permease component
NNL22_06025	COG0658	competence protein
NNL22_06025	COG2333	competence protein COMEC
NNL22_06030	COG0811	peptide transport
NNL22_06035	COG0848	biopolymer transport protein
NNL22_06040	COG1132	(ABC) transporter
NNL22_06045	COG1663	tetraacyldisaccharide 4'-kinase activity
NNL22_06050	COG2835	tetraacyldisaccharide 4'-kinase activity
NNL22_06055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NNL22_06060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NNL22_06075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NNL22_06080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NNL22_06095	COG0489	protein tyrosine kinase activity
NNL22_06110	COG1215	transferase activity, transferring glycosyl groups
NNL22_06115	COG0438	transferase activity, transferring glycosyl groups
NNL22_06125	COG1216	Glycosyl transferase, family 2
NNL22_06125	COG0463	Glycosyl transferase, family 2
NNL22_06130	COG1649	PFAM Uncharacterised BCR, COG1649
NNL22_06130	COG0726	polysaccharide deacetylase
NNL22_06135	COG0438	transferase activity, transferring glycosyl groups
NNL22_06140	COG1216	Glycosyl transferase, family 2
NNL22_06170	COG1216	Glycosyl transferase, family 2
NNL22_06225	COG2204	response regulator
NNL22_06230	COG4191	Histidine kinase
NNL22_06245	COG0204	Acyl-transferase
NNL22_06260	COG1309	transcriptional regulator
NNL22_06285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NNL22_06295	COG2062	phosphohistidine phosphatase, SixA
NNL22_06330	COG1104	cysteine desulfurase activity
NNL22_06370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NNL22_06385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NNL22_06400	COG0243	molybdopterin cofactor binding
NNL22_06405	COG1917	Cupin 2, conserved barrel domain protein
NNL22_06405	COG2207	Transcriptional regulator
NNL22_06410	COG0318	PFAM AMP-dependent synthetase and ligase
NNL22_06420	COG0277	FAD linked oxidase domain protein
NNL22_06435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNL22_06445	COG4770	biotin carboxylase activity
NNL22_06455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNL22_06460	COG1960	acyl-CoA dehydrogenase activity
NNL22_06550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NNL22_06550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NNL22_06550	COG1013	pyruvate-flavodoxin oxidoreductase activity
NNL22_06550	COG0674	pyruvate-flavodoxin oxidoreductase activity
NNL22_06560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NNL22_06570	COG2203	Gaf domain
NNL22_06570	COG5001	Diguanylate cyclase
NNL22_06570	COG4251	negative regulation of phosphorylation
NNL22_06570	COG3706	GGDEF domain
NNL22_06650	COG4667	esterase of the alpha-beta hydrolase superfamily
NNL22_06655	COG1024	Enoyl-CoA hydratase
NNL22_06655	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_06660	COG1012	belongs to the aldehyde dehydrogenase family
NNL22_06670	COG1454	alcohol dehydrogenase
NNL22_06675	COG1960	acyl-CoA dehydrogenase activity
NNL22_06730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NNL22_06740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NNL22_06800	COG2132	Multicopper oxidase
NNL22_06885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NNL22_06935	COG0583	DNA-binding transcription factor activity
NNL22_06955	COG0800	Aldolase
NNL22_06960	COG0129	dihydroxy-acid dehydratase activity
NNL22_06970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NNL22_06975	COG2815	serine threonine protein kinase
NNL22_06975	COG0515	serine threonine protein kinase
NNL22_06980	COG2116	formate transmembrane transporter activity
NNL22_06985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NNL22_07000	COG1902	pentaerythritol trinitrate reductase activity
NNL22_07000	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNL22_07010	COG0328	RNA-DNA hybrid ribonuclease activity
NNL22_07025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NNL22_07035	COG1960	acyl-CoA dehydrogenase activity
NNL22_07050	COG0243	molybdopterin cofactor binding
NNL22_07305	COG1960	acyl-CoA dehydrogenase activity
NNL22_07360	COG1999	signal sequence binding
NNL22_07375	COG0745	RESPONSE REGULATOR receiver
NNL22_07400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NNL22_07405	COG1074	ATP-dependent DNA helicase activity
NNL22_07410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NNL22_07425	COG0564	pseudouridine synthase activity
NNL22_07435	COG1846	Transcriptional regulator
NNL22_07440	COG0386	Belongs to the glutathione peroxidase family
NNL22_07450	COG0436	Aminotransferase
NNL22_07460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NNL22_07475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NNL22_07485	COG3101	peptidyl-lysine hydroxylation
NNL22_07495	COG0425	Belongs to the sulfur carrier protein TusA family
NNL22_07520	COG3278	Belongs to the heme-copper respiratory oxidase family
NNL22_07535	COG2010	Cytochrome c
NNL22_07540	COG0348	domain, Protein
NNL22_07570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NNL22_07580	COG0037	tRNA processing
NNL22_07585	COG1309	transcriptional regulator
NNL22_07595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NNL22_07625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NNL22_07635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NNL22_07640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NNL22_07645	COG0740	serine-type endopeptidase activity
NNL22_07650	COG0544	peptidyl-prolyl cis-trans isomerase activity
NNL22_07675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NNL22_07680	COG0215	cysteine-tRNA ligase activity
NNL22_07685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NNL22_07695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NNL22_07720	COG0604	alcohol dehydrogenase
NNL22_07720	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_07720	COG3321	synthase
NNL22_07730	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
NNL22_07735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNL22_07740	COG0604	alcohol dehydrogenase
NNL22_07740	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_07740	COG3321	synthase
NNL22_07750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNL22_07750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNL22_07755	COG1703	isobutyryl-CoA mutase activity
NNL22_07760	COG0604	alcohol dehydrogenase
NNL22_07770	COG0501	Belongs to the peptidase M48B family
NNL22_07775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NNL22_07780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NNL22_07785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NNL22_07790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NNL22_07795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NNL22_07810	COG0416	fatty acid biosynthetic process
NNL22_07815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NNL22_07820	COG1399	metal-binding, possibly nucleic acid-binding protein
NNL22_07835	COG0546	phosphoglycolate phosphatase activity
NNL22_07840	COG0564	pseudouridine synthase activity
NNL22_07845	COG1530	ribonuclease E activity
NNL22_07870	COG0613	PHP domain protein
NNL22_07875	COG2350	Protein conserved in bacteria
NNL22_07890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNL22_07910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NNL22_07925	COG1803	Methylglyoxal synthase
NNL22_07970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NNL22_07975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NNL22_07980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NNL22_07995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NNL22_08000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NNL22_08010	COG0584	glycerophosphoryl diester phosphodiesterase
NNL22_08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NNL22_08025	COG1477	protein flavinylation
NNL22_08030	COG2871	sodium ion transport
NNL22_08035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NNL22_08040	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NNL22_08050	COG1805	sodium ion transport
NNL22_08055	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NNL22_08065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NNL22_08085	COG0668	transmembrane transport
NNL22_08090	COG1472	Belongs to the glycosyl hydrolase 3 family
NNL22_08105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NNL22_08110	COG0004	ammonium transporteR
NNL22_08120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NNL22_08120	COG0617	tRNA 3'-terminal CCA addition
NNL22_08120	COG0517	IMP dehydrogenase activity
NNL22_08125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NNL22_08130	COG0307	riboflavin synthase, alpha
NNL22_08135	COG2813	Specifically methylates the guanine in position
NNL22_08140	COG4628	conserved protein (DUF2132)
NNL22_08145	COG0564	pseudouridine synthase activity
NNL22_08155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NNL22_08160	COG0830	nickel cation binding
NNL22_08170	COG0804	urea catabolic process
NNL22_08175	COG0832	Belongs to the urease beta subunit family
NNL22_08180	COG0831	urea catabolic process
NNL22_08185	COG0829	nickel cation binding
NNL22_08220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NNL22_08225	COG1607	acyl-coa hydrolase
NNL22_08230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNL22_08235	COG2813	Specifically methylates the guanine in position
NNL22_08250	COG0564	pseudouridine synthase activity
NNL22_08255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NNL22_08295	COG1278	Cold shock
NNL22_08315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNL22_08315	COG5322	oxidoreductase activity
NNL22_08320	COG1022	Amp-dependent synthetase and ligase
NNL22_08335	COG3768	UPF0283 membrane protein
NNL22_08340	COG3106	COG3106 Predicted ATPase
NNL22_08345	COG0385	Bile acid
NNL22_08350	COG0583	DNA-binding transcription factor activity
NNL22_08355	COG2259	Doxx family
NNL22_08485	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NNL22_08490	COG3344	reverse transcriptase
NNL22_08495	COG1518	maintenance of DNA repeat elements
NNL22_08505	COG2081	HI0933 family
NNL22_08510	COG0596	Alpha beta hydrolase
NNL22_08515	COG0778	Nitroreductase
NNL22_08520	COG3012	SEC-C Motif Domain Protein
NNL22_08525	COG2814	Major facilitator Superfamily
NNL22_08535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNL22_08540	COG2226	methyltransferase
NNL22_08555	COG2824	Alkylphosphonate utilization operon protein PhnA
NNL22_08560	COG5265	(ABC) transporter
NNL22_08565	COG0023	Translation Initiation Factor
NNL22_08580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NNL22_08605	COG2201	protein-glutamate methylesterase activity
NNL22_08610	COG3706	GGDEF domain
NNL22_08615	COG2837	iron assimilation
NNL22_08625	COG0326	Molecular chaperone. Has ATPase activity
NNL22_08660	COG2204	response regulator
NNL22_08715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NNL22_08720	COG4181	ATPase activity
NNL22_08730	COG0429	hydrolase of the alpha beta-hydrolase fold
NNL22_08750	COG1362	aminopeptidase activity
NNL22_08765	COG0116	Belongs to the methyltransferase superfamily
NNL22_08765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NNL22_08770	COG3130	regulation of translation
NNL22_08775	COG0167	dihydroorotate dehydrogenase activity
NNL22_08785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NNL22_08790	COG0556	nucleotide-excision repair
NNL22_08795	COG0436	Aminotransferase
NNL22_08810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NNL22_08820	COG0776	regulation of translation
NNL22_08830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NNL22_08835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NNL22_08840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNL22_08845	COG0077	Prephenate dehydratase
NNL22_08845	COG1605	Chorismate mutase
NNL22_08850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NNL22_08865	COG0788	formyltetrahydrofolate deformylase activity
NNL22_08870	COG2154	pterin-4-alpha-carbinolamine dehydratase
NNL22_08875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NNL22_08875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NNL22_08880	COG2267	carboxylic ester hydrolase activity
NNL22_08900	COG0137	argininosuccinate synthase activity
NNL22_08910	COG0418	dihydroorotase activity
NNL22_08915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NNL22_08920	COG0450	alkyl hydroperoxide reductase
NNL22_08925	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_08935	COG1025	Belongs to the peptidase M16 family
NNL22_08940	COG2925	Exonuclease
NNL22_08975	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NNL22_09000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NNL22_09000	COG0047	phosphoribosylformylglycinamidine synthase activity
NNL22_09005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NNL22_09010	COG2137	regulation of response to DNA damage stimulus
NNL22_09025	COG0183	Belongs to the thiolase family
NNL22_09030	COG1024	Enoyl-CoA hydratase
NNL22_09030	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_09050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NNL22_09055	COG0402	S-adenosylhomocysteine deaminase activity
NNL22_09060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNL22_09065	COG0546	phosphoglycolate phosphatase activity
NNL22_09070	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_09090	COG1138	Cytochrome C-type biogenesis protein
NNL22_09095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NNL22_09115	COG4133	protoheme IX ABC transporter activity
NNL22_09125	COG2257	FlhB HrpN YscU SpaS Family
NNL22_09135	COG3706	GGDEF domain
NNL22_09145	COG0835	chemotaxis
NNL22_09160	COG1192	Involved in chromosome partitioning
NNL22_09170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NNL22_09175	COG2201	protein-glutamate methylesterase activity
NNL22_09180	COG0784	Response regulator, receiver
NNL22_09180	COG2198	Histidine kinase
NNL22_09180	COG0643	Histidine kinase
NNL22_09185	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NNL22_09210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NNL22_09225	COG1987	bacterial-type flagellum assembly
NNL22_09235	COG3190	flagellar
NNL22_09265	COG0745	RESPONSE REGULATOR receiver
NNL22_09275	COG2201	protein-glutamate methylesterase activity
NNL22_09280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NNL22_09300	COG0745	RESPONSE REGULATOR receiver
NNL22_09310	COG0840	transmembrane signaling receptor activity
NNL22_09340	COG1677	Flagellar hook-basal body complex protein FliE
NNL22_09370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NNL22_09375	COG5016	pyruvate
NNL22_09375	COG0511	ligase activity, forming carbon-carbon bonds
NNL22_09380	COG3630	sodium ion export across plasma membrane
NNL22_09400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NNL22_09410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NNL22_09430	COG0795	lipopolysaccharide-transporting ATPase activity
NNL22_09435	COG0795	lipopolysaccharide-transporting ATPase activity
NNL22_09440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NNL22_09455	COG0525	valine-tRNA ligase activity
NNL22_09470	COG1940	carbohydrate kinase activity
NNL22_09485	COG3023	N-Acetylmuramoyl-L-alanine amidase
NNL22_09520	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NNL22_09525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NNL22_09530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NNL22_09540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NNL22_09545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NNL22_09555	COG1643	Atp-dependent helicase
NNL22_09560	COG0668	transmembrane transport
NNL22_09580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NNL22_09610	COG0204	Acyl-transferase
NNL22_09645	COG3706	GGDEF domain
NNL22_09670	COG3119	arylsulfatase activity
NNL22_09690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NNL22_09720	COG2738	Putative neutral zinc metallopeptidase
NNL22_09735	COG4771	TonB-dependent receptor
NNL22_09770	COG0183	Belongs to the thiolase family
NNL22_09790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNL22_09790	COG3153	acetyltransferase
NNL22_09800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NNL22_09805	COG0372	Belongs to the citrate synthase family
NNL22_09810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NNL22_09840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NNL22_09845	COG4191	Histidine kinase
NNL22_09850	COG4566	intracellular signal transduction
NNL22_09855	COG0739	heme binding
NNL22_09875	COG1067	ATP-dependent peptidase activity
NNL22_09895	COG0826	peptidase U32
NNL22_09900	COG0826	peptidase U32
NNL22_09905	COG1242	4 iron, 4 sulfur cluster binding
NNL22_09910	COG3154	lipid carrier protein
NNL22_09925	COG3385	transposase activity
NNL22_09930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NNL22_09935	COG0439	Biotin carboxylase
NNL22_09940	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NNL22_09950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NNL22_09965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NNL22_09970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NNL22_09975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NNL22_09985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NNL22_09990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NNL22_09995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NNL22_10000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NNL22_10020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NNL22_10030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NNL22_10035	COG0233	cytoplasmic translational termination
NNL22_10040	COG0528	UMP kinase activity
NNL22_10045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NNL22_10050	COG0052	Belongs to the universal ribosomal protein uS2 family
NNL22_10055	COG0024	Methionine aminopeptidase
NNL22_10060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NNL22_10065	COG0436	Aminotransferase
NNL22_10070	COG1393	Belongs to the ArsC family
NNL22_10075	COG2171	N-acyltransferase activity
NNL22_10080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NNL22_10085	COG2226	methyltransferase
NNL22_10105	COG2900	Belongs to the SlyX family
NNL22_10160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NNL22_10175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NNL22_10185	COG1086	Polysaccharide biosynthesis protein
NNL22_10195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NNL22_10225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NNL22_10235	COG2089	acid synthase
NNL22_10245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNL22_10245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NNL22_10250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NNL22_10255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NNL22_10270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NNL22_10275	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NNL22_10300	COG1088	dTDP-glucose 4,6-dehydratase activity
NNL22_10310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NNL22_10315	COG1555	photosystem II stabilization
NNL22_10320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NNL22_10325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NNL22_10370	COG0237	dephospho-CoA kinase activity
NNL22_10375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NNL22_10390	COG1346	cytolysis
NNL22_10395	COG1720	tRNA m6t6A37 methyltransferase activity
NNL22_10410	COG5002	protein histidine kinase activity
NNL22_10410	COG2205	protein histidine kinase activity
NNL22_10410	COG0784	Response regulator, receiver
NNL22_10420	COG0640	Transcriptional regulator
NNL22_10455	COG2197	response regulator
NNL22_10470	COG0183	Belongs to the thiolase family
NNL22_10475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NNL22_10495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NNL22_10500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NNL22_10505	COG5007	Belongs to the BolA IbaG family
NNL22_10525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NNL22_10530	COG1127	ABC transporter
NNL22_10555	COG1137	ATPase activity
NNL22_10575	COG1660	Displays ATPase and GTPase activities
NNL22_10580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NNL22_10585	COG2239	Acts as a magnesium transporter
NNL22_10590	COG3028	Belongs to the UPF0307 family
NNL22_10595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNL22_10605	COG1530	ribonuclease E activity
NNL22_10610	COG0424	maF-like protein
NNL22_10615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NNL22_10620	COG1792	Involved in formation and maintenance of cell shape
NNL22_10625	COG1077	Cell shape determining protein MreB Mrl
NNL22_10630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NNL22_10635	COG0154	amidase activity
NNL22_10640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NNL22_10645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NNL22_10650	COG1381	Involved in DNA repair and RecF pathway recombination
NNL22_10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NNL22_10660	COG0571	ribonuclease III activity
NNL22_10670	COG0681	Belongs to the peptidase S26 family
NNL22_10675	COG0481	GTPase activity
NNL22_10685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NNL22_10740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NNL22_10750	COG0824	Thioesterase
NNL22_10755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NNL22_10770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NNL22_10775	COG0335	large ribosomal subunit rRNA binding
NNL22_10785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NNL22_10790	COG0228	four-way junction DNA binding
NNL22_10795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NNL22_10800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NNL22_10805	COG4536	flavin adenine dinucleotide binding
NNL22_10820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NNL22_10830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNL22_10835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NNL22_10840	COG3842	ATPase activity
NNL22_10845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NNL22_10860	COG2205	protein histidine kinase activity
NNL22_10865	COG0745	RESPONSE REGULATOR receiver
NNL22_10895	COG2353	YceI-like domain
NNL22_10900	COG3038	cytochrome b561
NNL22_10905	COG2200	EAL domain
NNL22_10905	COG2199	diguanylate cyclase activity
NNL22_10915	COG3091	SprT-like family
NNL22_10920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNL22_10925	COG3588	fructose-bisphosphate aldolase
NNL22_10930	COG2816	NAD+ diphosphatase activity
NNL22_10970	COG3228	Belongs to the MtfA family
NNL22_10980	COG0417	DNA replication proofreading
NNL22_10995	COG4628	conserved protein (DUF2132)
NNL22_11010	COG0488	(ABC) transporter
NNL22_11015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NNL22_11030	COG0523	cobalamin synthesis protein
NNL22_11050	COG0840	transmembrane signaling receptor activity
NNL22_11055	COG0840	transmembrane signaling receptor activity
NNL22_11075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NNL22_11100	COG2815	serine threonine protein kinase
NNL22_11100	COG0515	serine threonine protein kinase
NNL22_11125	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NNL22_11135	COG1280	lysine exporter protein (LysE YggA)
NNL22_11150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NNL22_11175	COG1280	lysine exporter protein (LysE YggA)
NNL22_11205	COG1187	pseudouridine synthase activity
NNL22_11210	COG0513	Belongs to the DEAD box helicase family
NNL22_11215	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NNL22_11220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NNL22_11230	COG0204	Acyl-transferase
NNL22_11235	COG1061	Type III restriction enzyme res subunit
NNL22_11275	COG1012	belongs to the aldehyde dehydrogenase family
NNL22_11280	COG1309	transcriptional regulator
NNL22_11285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NNL22_11290	COG0420	3'-5' exonuclease activity
NNL22_11295	COG0419	ATPase involved in DNA repair
NNL22_11310	COG0513	Belongs to the DEAD box helicase family
NNL22_11335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NNL22_11365	COG1132	(ABC) transporter
NNL22_11380	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NNL22_11385	COG5380	lipid catabolic process
NNL22_11390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NNL22_11420	COG1309	transcriptional regulator
NNL22_11430	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_11435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNL22_11440	COG1960	acyl-CoA dehydrogenase activity
NNL22_11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_11445	COG1024	Enoyl-CoA hydratase
NNL22_11480	COG0583	DNA-binding transcription factor activity
NNL22_11490	COG0189	ligase activity
NNL22_11500	COG0189	ligase activity
NNL22_11500	COG4067	protein conserved in archaea
NNL22_11505	COG1376	ErfK ybiS ycfS ynhG family protein
NNL22_11505	COG1388	LysM domain
NNL22_11515	COG2252	PERMEase
NNL22_11520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NNL22_11545	COG2239	Acts as a magnesium transporter
NNL22_11550	COG2239	Acts as a magnesium transporter
NNL22_11555	COG0668	transmembrane transport
NNL22_11565	COG1285	pathogenesis
NNL22_11580	COG0179	Fumarylacetoacetate (FAA) hydrolase
NNL22_11585	COG0277	FAD linked oxidase domain protein
NNL22_11590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NNL22_11595	COG2885	chlorophyll binding
NNL22_11625	COG0513	Belongs to the DEAD box helicase family
NNL22_11630	COG0569	domain protein
NNL22_11630	COG0189	ligase activity
NNL22_11640	COG0189	ligase activity
NNL22_11640	COG4067	protein conserved in archaea
NNL22_11645	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NNL22_11645	COG3264	Mechanosensitive ion channel
NNL22_11655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NNL22_11670	COG0126	phosphoglycerate kinase activity
NNL22_11675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NNL22_11680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NNL22_11750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NNL22_11755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NNL22_11760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NNL22_11765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NNL22_11770	COG1566	PFAM secretion protein HlyD family protein
NNL22_11780	COG4399	Belongs to the UPF0754 family
NNL22_11800	COG0432	Pfam Uncharacterised protein family UPF0047
NNL22_11805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NNL22_11810	COG2766	serine protein kinase
NNL22_11815	COG2718	Belongs to the UPF0229 family
NNL22_11820	COG2719	SpoVR family
NNL22_11840	COG0719	Fe-S assembly protein
NNL22_11845	COG0396	ATPase activity
NNL22_11850	COG0719	Fe-S assembly protein
NNL22_11855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NNL22_11860	COG0316	Belongs to the HesB IscA family
NNL22_11870	COG2166	iron-sulfur cluster assembly
NNL22_11895	COG0205	6-phosphofructokinase activity
NNL22_11925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NNL22_11935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NNL22_11965	COG0288	reversible hydration of carbon dioxide
NNL22_11970	COG0583	DNA-binding transcription factor activity
NNL22_11985	COG0500	methyltransferase
NNL22_11995	COG0028	Belongs to the TPP enzyme family
NNL22_12015	COG4807	Protein conserved in bacteria
NNL22_12035	COG4181	ATPase activity
NNL22_12065	COG0583	DNA-binding transcription factor activity
NNL22_12070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NNL22_12075	COG3112	Uncharacterised protein family (UPF0231)
NNL22_12090	COG0515	serine threonine protein kinase
NNL22_12090	COG2815	serine threonine protein kinase
NNL22_12095	COG2223	nitrite transmembrane transporter activity
NNL22_12100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNL22_12110	COG0243	molybdopterin cofactor binding
NNL22_12115	COG0346	lactoylglutathione lyase activity
NNL22_12120	COG3119	arylsulfatase activity
NNL22_12150	COG1187	pseudouridine synthase activity
NNL22_12155	COG0217	transcriptional regulatory protein
NNL22_12205	COG0500	methyltransferase
NNL22_12210	COG3706	GGDEF domain
NNL22_12220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NNL22_12240	COG0321	lipoyl(octanoyl) transferase activity
NNL22_12245	COG2921	Belongs to the UPF0250 family
NNL22_12250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NNL22_12255	COG1686	Belongs to the peptidase S11 family
NNL22_12260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NNL22_12265	COG2951	lytic endotransglycosylase activity
NNL22_12270	COG0772	Belongs to the SEDS family
NNL22_12275	COG0768	penicillin binding
NNL22_12280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NNL22_12290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NNL22_12295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NNL22_12310	COG0586	Pfam SNARE associated Golgi protein
NNL22_12315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NNL22_12325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NNL22_12335	COG0129	dihydroxy-acid dehydratase activity
NNL22_12340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NNL22_12345	COG0840	transmembrane signaling receptor activity
NNL22_12345	COG0840	transmembrane signaling receptor activity
NNL22_12350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NNL22_12355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NNL22_12360	COG0730	response to heat
NNL22_12380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NNL22_12390	COG0142	geranyltranstransferase activity
NNL22_12395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NNL22_12400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NNL22_12405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NNL22_12410	COG0315	cyclic pyranopterin monophosphate synthase activity
NNL22_12415	COG0352	thiamine-phosphate diphosphorylase activity
NNL22_12420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NNL22_12425	COG0653	protein targeting
NNL22_12430	COG0739	heme binding
NNL22_12440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NNL22_12455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NNL22_12460	COG1181	Belongs to the D-alanine--D-alanine ligase family
NNL22_12465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NNL22_12470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NNL22_12475	COG0772	Belongs to the SEDS family
NNL22_12480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NNL22_12485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NNL22_12490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NNL22_12495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NNL22_12510	COG0275	rRNA processing
NNL22_12515	COG2001	Belongs to the MraZ family
NNL22_12525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NNL22_12535	COG0792	nuclease activity
NNL22_12545	COG2969	positive regulation of protein catabolic process
NNL22_12550	COG0625	glutathione transferase activity
NNL22_12555	COG2857	Cytochrome c1
NNL22_12560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NNL22_12565	COG0723	plastoquinol--plastocyanin reductase activity
NNL22_12570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NNL22_12575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NNL22_12580	COG0084	hydrolase, TatD family'
NNL22_12585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NNL22_12590	COG4191	Histidine kinase
NNL22_12595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NNL22_12600	COG0456	acetyltransferase
NNL22_12610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNL22_12650	COG1183	phosphatidylcholine synthase activity
NNL22_12660	COG0028	Belongs to the TPP enzyme family
NNL22_12695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NNL22_12695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNL22_12760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NNL22_12765	COG1047	Peptidyl-prolyl cis-trans
NNL22_12775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NNL22_12780	COG0196	riboflavin kinase activity
NNL22_12785	COG0728	peptidoglycan biosynthetic process
NNL22_12790	COG0268	Binds directly to 16S ribosomal RNA
NNL22_12795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NNL22_12800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NNL22_12805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NNL22_12810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NNL22_12815	COG0142	geranyltranstransferase activity
NNL22_12825	COG2078	PFAM AMMECR1 domain protein
NNL22_12830	COG1355	regulation of microtubule-based process
NNL22_12845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NNL22_12855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NNL22_12860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NNL22_12875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NNL22_12875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NNL22_12880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NNL22_12885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NNL22_12890	COG0488	(ABC) transporter
NNL22_12910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NNL22_12915	COG0493	'glutamate synthase
NNL22_12920	COG0067	glutamate synthase
NNL22_12920	COG0070	glutamate synthase
NNL22_12920	COG0069	glutamate synthase activity
NNL22_12930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NNL22_12935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NNL22_12985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NNL22_13000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NNL22_13005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NNL22_13010	COG0405	Gamma-glutamyltransferase
NNL22_13030	COG0628	permease
NNL22_13065	COG1444	tRNA N-acetyltransferase activity
NNL22_13080	COG1960	acyl-CoA dehydrogenase activity
NNL22_13115	COG0076	glutamate decarboxylase activity
NNL22_13130	COG3706	GGDEF domain
NNL22_13130	COG4251	negative regulation of phosphorylation
NNL22_13130	COG5001	Diguanylate cyclase
NNL22_13130	COG2203	Gaf domain
NNL22_13135	COG0306	phosphate transporter
NNL22_13160	COG1946	Acyl-CoA thioesterase
NNL22_13185	COG3161	chorismate lyase activity
NNL22_13190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NNL22_13220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NNL22_13225	COG1119	ATPase activity
NNL22_13245	COG0564	pseudouridine synthase activity
NNL22_13255	COG2264	protein methyltransferase activity
NNL22_13260	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NNL22_13265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NNL22_13270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NNL22_13275	COG3639	organic phosphonate transmembrane transporter activity
NNL22_13280	COG0709	Synthesizes selenophosphate from selenide and ATP
NNL22_13285	COG0668	transmembrane transport
NNL22_13295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNL22_13300	COG0537	adenosine 5'-monophosphoramidase activity
NNL22_13315	COG0704	Plays a role in the regulation of phosphate uptake
NNL22_13320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NNL22_13325	COG0581	inorganic phosphate transmembrane transporter activity
NNL22_13350	COG1607	acyl-coa hydrolase
NNL22_13360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NNL22_13380	COG1765	OsmC-like protein
NNL22_13390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NNL22_13395	COG3954	Phosphoribulokinase
NNL22_13400	COG5001	Diguanylate cyclase
NNL22_13400	COG5002	protein histidine kinase activity
NNL22_13410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NNL22_13410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NNL22_13425	COG3706	GGDEF domain
NNL22_13430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NNL22_13440	COG0756	dUTP diphosphatase activity
NNL22_13445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NNL22_13450	COG2003	Belongs to the UPF0758 family
NNL22_13455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NNL22_13460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NNL22_13465	COG0281	malic enzyme
NNL22_13475	COG0254	rRNA binding
NNL22_13480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NNL22_13485	COG0018	arginyl-trna synthetase
NNL22_13495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NNL22_13500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NNL22_13515	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NNL22_13520	COG0494	nUDIX hydrolase
NNL22_13535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NNL22_13545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NNL22_13550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NNL22_13555	COG0509	glycine decarboxylation via glycine cleavage system
NNL22_13560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NNL22_13565	COG3150	esterase
NNL22_13570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NNL22_13580	COG0494	nUDIX hydrolase
NNL22_13585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NNL22_13590	COG1538	Outer membrane efflux protein
NNL22_13595	COG1519	Transferase
NNL22_13610	COG0726	polysaccharide deacetylase
NNL22_13625	COG1215	transferase activity, transferring glycosyl groups
NNL22_13640	COG0463	Glycosyl transferase, family 2
NNL22_13650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NNL22_13700	COG4160	amino acid transport
NNL22_13705	COG2988	succinylglutamate desuccinylase activity
NNL22_13710	COG3724	N-succinylarginine dihydrolase activity
NNL22_13715	COG1012	belongs to the aldehyde dehydrogenase family
NNL22_13730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNL22_13735	COG0840	transmembrane signaling receptor activity
NNL22_13770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NNL22_13785	COG4106	trans-aconitate 2-methyltransferase activity
NNL22_13790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNL22_13795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NNL22_13800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NNL22_13810	COG0330	HflC and HflK could
NNL22_13815	COG0330	HflC and HflK could
NNL22_13820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NNL22_13825	COG1923	regulation of RNA biosynthetic process
NNL22_13830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NNL22_13835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NNL22_13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
NNL22_13845	COG0802	atpase or kinase
NNL22_13850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NNL22_13850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NNL22_13860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NNL22_13865	COG1162	GTPase activity
NNL22_13870	COG1360	Flagellar Motor Protein
NNL22_13890	COG0688	phosphatidylethanolamine metabolic process
NNL22_13895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NNL22_13900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NNL22_13905	COG1509	lysine 2,3-aminomutase activity
NNL22_13920	COG0560	Phosphoserine phosphatase
NNL22_13920	COG3830	Belongs to the UPF0237 family
NNL22_13930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NNL22_13935	COG0850	regulation of cytokinetic process
NNL22_13940	COG2894	cell division
NNL22_13945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NNL22_13965	COG1309	transcriptional regulator
NNL22_13970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NNL22_14000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NNL22_14005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NNL22_14010	COG2890	protein-(glutamine-N5) methyltransferase activity
NNL22_14015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NNL22_14020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NNL22_14030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NNL22_14035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NNL22_14045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NNL22_14050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NNL22_14055	COG0193	aminoacyl-tRNA hydrolase activity
NNL22_14060	COG0012	GTP binding
NNL22_14100	COG0405	Gamma-glutamyltransferase
NNL22_14125	COG3706	GGDEF domain
NNL22_14125	COG4251	negative regulation of phosphorylation
NNL22_14125	COG5001	Diguanylate cyclase
NNL22_14125	COG2203	Gaf domain
NNL22_14160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NNL22_14165	COG3047	cAMP biosynthetic process
NNL22_14175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NNL22_14180	COG0305	Participates in initiation and elongation during chromosome replication
NNL22_14185	COG0359	binds to the 23S rRNA
NNL22_14195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NNL22_14200	COG0360	Binds together with S18 to 16S ribosomal RNA
NNL22_14205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NNL22_14210	COG0557	exoribonuclease II activity
NNL22_14245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NNL22_14245	COG1199	ATP-dependent helicase activity
NNL22_14275	COG1136	(ABC) transporter
NNL22_14275	COG0577	efflux transmembrane transporter activity
NNL22_14280	COG4591	ABC-type transport system involved in lipoprotein release permease component
NNL22_14285	COG0577	efflux transmembrane transporter activity
NNL22_14285	COG1136	(ABC) transporter
NNL22_14295	COG1607	acyl-coa hydrolase
NNL22_14315	COG0247	lactate metabolic process
NNL22_14320	COG1139	Iron-sulfur cluster binding protein
NNL22_14390	COG2945	thiolester hydrolase activity
NNL22_14395	COG1185	polyribonucleotide nucleotidyltransferase activity
NNL22_14400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NNL22_14405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NNL22_14410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NNL22_14415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NNL22_14415	COG3064	Membrane
NNL22_14420	COG0195	Participates in both transcription termination and antitermination
NNL22_14425	COG0779	Required for maturation of 30S ribosomal subunits
NNL22_14435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NNL22_14440	COG0149	triose-phosphate isomerase activity
NNL22_14445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NNL22_14450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NNL22_14455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NNL22_14460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NNL22_14485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NNL22_14490	COG0484	heat shock protein binding
NNL22_14495	COG0443	Heat shock 70 kDa protein
NNL22_14500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NNL22_14505	COG0497	DNA recombination
NNL22_14520	COG2914	Belongs to the UPF0125 (RnfH) family
NNL22_14530	COG0733	neurotransmitter:sodium symporter activity
NNL22_14535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NNL22_14545	COG0582	viral genome integration into host DNA
NNL22_14570	COG2003	Belongs to the UPF0758 family
NNL22_14575	COG0582	viral genome integration into host DNA
NNL22_14595	COG0464	growth
NNL22_14610	COG4983	Phage plasmid primase, P4 family domain protein
NNL22_14615	COG3311	Transcriptional regulator
NNL22_14705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NNL22_14755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NNL22_14790	COG0071	Belongs to the small heat shock protein (HSP20) family
NNL22_14805	COG5001	Diguanylate cyclase
NNL22_14805	COG3300	MHYT domain
NNL22_14820	COG3040	lipid binding
NNL22_14825	COG1090	epimerase
NNL22_14830	COG0789	Transcriptional regulator
NNL22_14855	COG2204	response regulator
NNL22_14865	COG2205	protein histidine kinase activity
NNL22_14875	COG2205	protein histidine kinase activity
NNL22_14880	COG0514	ATP-dependent DNA helicase (RecQ)
NNL22_14915	COG0628	permease
NNL22_14920	COG1309	transcriptional regulator
NNL22_14945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NNL22_14955	COG3268	Saccharopine dehydrogenase
NNL22_14970	COG1408	metallophosphoesterase
NNL22_15015	COG0318	PFAM AMP-dependent synthetase and ligase
NNL22_15025	COG2226	methyltransferase
NNL22_15035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NNL22_15040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NNL22_15045	COG0140	phosphoribosyl-ATP diphosphatase activity
NNL22_15050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNL22_15055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNL22_15065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NNL22_15075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNL22_15080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNL22_15085	COG0006	proline dipeptidase activity
NNL22_15090	COG3079	Belongs to the UPF0149 family
NNL22_15110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NNL22_15125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NNL22_15145	COG2814	Major facilitator Superfamily
NNL22_15150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NNL22_15190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NNL22_15205	COG2205	protein histidine kinase activity
NNL22_15205	COG0784	Response regulator, receiver
NNL22_15210	COG1960	acyl-CoA dehydrogenase activity
NNL22_15220	COG0348	domain, Protein
NNL22_15220	COG3901	Regulator of nitric oxide reductase transcription
NNL22_15225	COG4263	nitrous-oxide reductase activity
NNL22_15240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NNL22_15255	COG5001	Diguanylate cyclase
NNL22_15255	COG3300	MHYT domain
NNL22_15265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NNL22_15270	COG0511	ligase activity, forming carbon-carbon bonds
NNL22_15280	COG2264	protein methyltransferase activity
NNL22_15305	COG0151	Belongs to the GarS family
NNL22_15310	COG0786	glutamate:sodium symporter activity
NNL22_15320	COG0678	peroxiredoxin activity
NNL22_15320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NNL22_15330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NNL22_15355	COG0077	Prephenate dehydratase
NNL22_15355	COG1605	Chorismate mutase
NNL22_15360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NNL22_15365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NNL22_15375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NNL22_15400	COG1309	transcriptional regulator
NNL22_15405	COG2022	thiamine diphosphate biosynthetic process
NNL22_15415	COG2363	Small membrane protein
NNL22_15420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NNL22_15425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NNL22_15430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NNL22_15435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NNL22_15440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NNL22_15445	COG3178	'Phosphotransferase
NNL22_15450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NNL22_15460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NNL22_15465	COG0546	phosphoglycolate phosphatase activity
NNL22_15470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NNL22_15480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NNL22_15485	COG0134	indole-3-glycerol-phosphate synthase activity
NNL22_15495	COG3678	ATP-independent chaperone mediated protein folding
NNL22_15500	COG0745	RESPONSE REGULATOR receiver
NNL22_15505	COG2205	protein histidine kinase activity
NNL22_15510	COG0745	RESPONSE REGULATOR receiver
NNL22_15515	COG5002	protein histidine kinase activity
NNL22_15520	COG1272	protein, Hemolysin III
NNL22_15540	COG0435	Glutathione S-transferase
NNL22_15575	COG3038	cytochrome b561
NNL22_15630	COG1396	sequence-specific DNA binding
NNL22_15630	COG3800	Transcriptional regulator
NNL22_15635	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NNL22_15655	COG3210	domain, Protein
NNL22_15660	COG2831	hemolysin activation secretion protein
NNL22_15675	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NNL22_15680	COG0210	DNA helicase
NNL22_15715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NNL22_15735	COG1794	racemase activity, acting on amino acids and derivatives
NNL22_15740	COG2315	Protein conserved in bacteria
NNL22_15745	COG0517	IMP dehydrogenase activity
NNL22_15745	COG0516	GMP reductase activity
NNL22_15750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NNL22_15750	COG0519	Catalyzes the synthesis of GMP from XMP
NNL22_15775	COG0604	alcohol dehydrogenase
NNL22_15780	COG0686	Belongs to the AlaDH PNT family
NNL22_15790	COG3437	response regulator, receiver
NNL22_15805	COG1454	alcohol dehydrogenase
NNL22_15835	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NNL22_15855	COG0301	tRNA thio-modification
NNL22_15855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NNL22_15860	COG1611	Belongs to the LOG family
NNL22_15885	COG1960	acyl-CoA dehydrogenase activity
NNL22_15890	COG1024	Enoyl-CoA hydratase
NNL22_15895	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNL22_15895	COG1024	Enoyl-CoA hydratase
NNL22_15915	COG0210	DNA helicase
NNL22_15925	COG2072	flavoprotein involved in K transport
NNL22_15930	COG1752	Esterase of the alpha-beta hydrolase superfamily
NNL22_16000	COG4115	mRNA cleavage
NNL22_16055	COG3547	Transposase (IS116 IS110 IS902 family)
NNL22_16205	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NNL22_16205	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NNL22_16210	COG0745	RESPONSE REGULATOR receiver
NNL22_16215	COG2205	protein histidine kinase activity
NNL22_16255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NNL22_16270	COG5002	protein histidine kinase activity
NNL22_16280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NNL22_16290	COG2177	Part of the ABC transporter FtsEX involved in
NNL22_16295	COG2884	Cell division ATP-binding protein ftsE
NNL22_16300	COG0552	protein localization to endoplasmic reticulum
NNL22_16305	COG0742	ribosomal rna small subunit methyltransferase
NNL22_16315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NNL22_16330	COG1011	Hydrolase
NNL22_16335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NNL22_16345	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NNL22_16380	COG2095	MarC family integral membrane protein
NNL22_16390	COG0540	Belongs to the ATCase OTCase family
NNL22_16400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NNL22_16405	COG1678	Uncharacterized ACR, COG1678
NNL22_16415	COG0189	ligase activity
NNL22_16435	COG0840	transmembrane signaling receptor activity
NNL22_16450	COG2201	protein-glutamate methylesterase activity
NNL22_16470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NNL22_16480	COG0204	Acyl-transferase
NNL22_16495	COG1309	transcriptional regulator
NNL22_16515	COG2918	glutathione biosynthetic process
NNL22_16520	COG2183	response to ionizing radiation
NNL22_16535	COG1943	Transposase
NNL22_16540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NNL22_16545	COG1695	Transcriptional regulator
NNL22_16585	COG1785	Belongs to the alkaline phosphatase family
NNL22_16595	COG1742	UPF0060 membrane protein
NNL22_16600	COG1114	Component of the transport system for branched-chain amino acids
NNL22_16615	COG3239	Fatty acid desaturase
NNL22_16620	COG2871	sodium ion transport
NNL22_16630	COG1278	Cold shock
NNL22_16640	COG1301	dicarboxylic acid transport
NNL22_16675	COG0714	Associated with various cellular activities
NNL22_16680	COG3119	arylsulfatase activity
NNL22_16690	COG0657	acetylesterase activity
NNL22_16705	COG1760	l-serine dehydratase
NNL22_16720	COG0596	Alpha beta hydrolase
NNL22_16740	COG0069	glutamate synthase activity
NNL22_16760	COG1127	ABC transporter
NNL22_16765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NNL22_16780	COG4335	DNA alkylation repair
NNL22_16885	COG2911	Protein conserved in bacteria
NNL22_16900	COG3713	MltA-interacting MipA family protein
NNL22_16915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NNL22_16975	COG1752	Esterase of the alpha-beta hydrolase superfamily
NNL22_16985	COG3300	MHYT domain
NNL22_16985	COG5001	Diguanylate cyclase
NNL22_16990	COG4206	TonB-dependent receptor
NNL22_17005	COG1120	ATPase activity
NNL22_17020	COG2198	Histidine kinase
NNL22_17020	COG2205	protein histidine kinase activity
NNL22_17020	COG0784	Response regulator, receiver
NNL22_17040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NNL22_17045	COG0019	diaminopimelate decarboxylase activity
NNL22_17060	COG5002	protein histidine kinase activity
NNL22_17060	COG5001	Diguanylate cyclase
NNL22_17065	COG0165	Argininosuccinate lyase
NNL22_17070	COG0745	RESPONSE REGULATOR receiver
NNL22_17070	COG2972	Histidine kinase
NNL22_17080	COG0181	hydroxymethylbilane synthase activity
NNL22_17090	COG2959	enzyme of heme biosynthesis
NNL22_17095	COG3071	HemY protein
NNL22_17110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NNL22_17125	COG0521	Mo-molybdopterin cofactor biosynthetic process
NNL22_17130	COG0303	'Molybdopterin
NNL22_17135	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NNL22_17140	COG0314	molybdopterin synthase activity
NNL22_17145	COG0746	molybdenum cofactor guanylyltransferase activity
NNL22_17155	COG2197	response regulator
NNL22_17160	COG3850	Histidine kinase
NNL22_17175	COG0243	molybdopterin cofactor binding
NNL22_17180	COG0437	4 iron, 4 sulfur cluster binding
NNL22_17185	COG0348	domain, Protein
NNL22_17190	COG3043	anaerobic respiration
NNL22_17195	COG3005	denitrification pathway
NNL22_17230	COG0488	(ABC) transporter
NNL22_17260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NNL22_17275	COG0302	gtp cyclohydrolase
NNL22_17280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NNL22_17285	COG1832	CoA-binding protein
NNL22_17325	COG1272	protein, Hemolysin III
NNL22_17350	COG2119	membrane
NNL22_17355	COG0789	Transcriptional regulator
NNL22_17360	COG2217	Heavy metal translocating P-type atpase
NNL22_17375	COG1366	Belongs to the anti-sigma-factor antagonist family
NNL22_17385	COG0557	exoribonuclease II activity
NNL22_17430	COG5001	Diguanylate cyclase
NNL22_17430	COG4251	negative regulation of phosphorylation
NNL22_17430	COG2203	Gaf domain
NNL22_17430	COG3706	GGDEF domain
NNL22_17440	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NNL22_17445	COG0133	tryptophan synthase activity
NNL22_17455	COG0534	Mate efflux family protein
NNL22_17465	COG0668	transmembrane transport
NNL22_17470	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNL22_17470	COG1902	pentaerythritol trinitrate reductase activity
NNL22_17490	COG2304	oxidoreductase activity
NNL22_17505	COG4191	Histidine kinase
NNL22_17510	COG1028	Short-chain dehydrogenase reductase Sdr
NNL22_17510	COG3321	synthase
NNL22_17510	COG0604	alcohol dehydrogenase
NNL22_17520	COG2095	MarC family integral membrane protein
NNL22_17530	COG0443	Heat shock 70 kDa protein
NNL22_17545	COG1538	Outer membrane efflux protein
NNL22_17560	COG3851	Histidine kinase
NNL22_17595	COG2169	Transcriptional regulator
NNL22_17595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NNL22_17600	COG0071	Belongs to the small heat shock protein (HSP20) family
NNL22_17605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NNL22_17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNL22_17620	COG0848	biopolymer transport protein
NNL22_17625	COG0811	peptide transport
NNL22_17630	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NNL22_17635	COG4771	TonB-dependent receptor
NNL22_17645	COG0748	coenzyme F420 binding
NNL22_17665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNL22_17665	COG5322	oxidoreductase activity
NNL22_17670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNL22_17700	COG2067	long-chain fatty acid transport protein
NNL22_17705	COG0490	domain, Protein
NNL22_17705	COG0471	metal ion transport
NNL22_17730	COG2814	Major facilitator Superfamily
NNL22_17765	COG3604	Transcriptional regulator
NNL22_17770	COG0348	domain, Protein
NNL22_17785	COG1280	lysine exporter protein (LysE YggA)
NNL22_17795	COG0443	Heat shock 70 kDa protein
NNL22_17810	COG3046	protein related to deoxyribodipyrimidine photolyase
NNL22_17835	COG1252	NADH dehydrogenase
NNL22_17845	COG0583	DNA-binding transcription factor activity
NNL22_17895	COG1279	arginine transmembrane transporter activity
NNL22_17900	COG0583	DNA-binding transcription factor activity
NNL22_17905	COG0545	Peptidyl-prolyl cis-trans isomerase
NNL22_17920	COG2703	oxygen carrier activity
NNL22_17940	COG2111	Na H antiporter
NNL22_17940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NNL22_17945	COG1006	Multisubunit Na H antiporter MnhC subunit
NNL22_17950	COG0651	ATP synthesis coupled electron transport
NNL22_17955	COG1863	multisubunit Na H antiporter MnhE subunit
NNL22_17960	COG2212	antiporter activity
NNL22_17965	COG1320	monovalent cation:proton antiporter activity
NNL22_17995	COG1288	antiporter activity
NNL22_18015	COG0531	amino acid
NNL22_18020	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NNL22_18055	COG1230	cation diffusion facilitator family transporter
NNL22_18080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NNL22_18085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NNL22_18090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NNL22_18095	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NNL22_18100	COG1178	ABC-type Fe3 transport system permease component
NNL22_18105	COG4143	(ABC) transporter
NNL22_18125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NNL22_18130	COG0640	Transcriptional regulator
NNL22_18175	COG1132	(ABC) transporter
NNL22_18180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NNL22_18215	COG2198	Histidine kinase
NNL22_18215	COG5002	protein histidine kinase activity
NNL22_18215	COG0784	Response regulator, receiver
NNL22_18225	COG2095	MarC family integral membrane protein
NNL22_18245	COG0848	biopolymer transport protein
NNL22_18250	COG0811	peptide transport
NNL22_18255	COG0811	peptide transport
NNL22_18310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNL22_18315	COG1773	rubredoxin
NNL22_18320	COG1773	rubredoxin
NNL22_18325	COG3239	Fatty acid desaturase
NNL22_18330	COG2113	Glycine betaine
NNL22_18335	COG4176	ABC-type proline glycine betaine transport system permease component
NNL22_18340	COG4175	Glycine betaine
NNL22_18390	COG3550	peptidyl-serine autophosphorylation
NNL22_18480	COG1797	cobyrinic acid a,c-diamide synthase activity
NNL22_18560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NNL22_18580	COG0659	secondary active sulfate transmembrane transporter activity
NNL22_18595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NNL22_18600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NNL22_18605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NNL22_18610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NNL22_18615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NNL22_18620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NNL22_18625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NNL22_18630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NNL22_18640	COG0356	it plays a direct role in the translocation of protons across the membrane
NNL22_18650	COG1475	DNA binding
NNL22_18655	COG1192	Involved in chromosome partitioning
NNL22_18660	COG0357	Ribosomal RNA small subunit methyltransferase G
NNL22_18665	COG0445	tRNA wobble uridine modification
NNL22_18675	COG0426	domain, Protein
NNL22_18675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NNL22_18685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34