locus-tag	class	description
NKI27_00005	COG0706	membrane insertase activity
NKI27_00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NKI27_00015	COG0426	domain, Protein
NKI27_00015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NKI27_00025	COG0445	tRNA wobble uridine modification
NKI27_00030	COG0357	Ribosomal RNA small subunit methyltransferase G
NKI27_00035	COG1192	Involved in chromosome partitioning
NKI27_00040	COG1475	DNA binding
NKI27_00050	COG0356	it plays a direct role in the translocation of protons across the membrane
NKI27_00060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NKI27_00065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NKI27_00070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NKI27_00075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NKI27_00080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NKI27_00085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NKI27_00090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NKI27_00095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NKI27_00115	COG0659	secondary active sulfate transmembrane transporter activity
NKI27_00135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NKI27_00145	COG1797	cobyrinic acid a,c-diamide synthase activity
NKI27_00195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NKI27_00225	COG1773	rubredoxin
NKI27_00230	COG1773	rubredoxin
NKI27_00235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NKI27_00285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NKI27_00290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NKI27_00330	COG0811	peptide transport
NKI27_00335	COG0811	peptide transport
NKI27_00340	COG0848	biopolymer transport protein
NKI27_00360	COG3609	addiction module antidote protein, CC2985 family
NKI27_00365	COG0488	(ABC) transporter
NKI27_00375	COG2095	MarC family integral membrane protein
NKI27_00390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NKI27_00395	COG3639	organic phosphonate transmembrane transporter activity
NKI27_00400	COG2188	Transcriptional regulator
NKI27_00405	COG3624	Phosphonate C-P lyase system protein PhnG
NKI27_00410	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NKI27_00415	COG3626	phosphonate metabolism
NKI27_00420	COG3627	carbon phosphorus lyase activity
NKI27_00425	COG4107	phosphonate C-P lyase system protein PhnK
NKI27_00430	COG4778	phosphonate C-P lyase system protein PhnL
NKI27_00435	COG3454	Phosphonate metabolism
NKI27_00440	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NKI27_00445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NKI27_00475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NKI27_00480	COG0583	DNA-binding transcription factor activity
NKI27_00490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NKI27_00500	COG1132	(ABC) transporter
NKI27_00510	COG3706	GGDEF domain
NKI27_00535	COG0640	Transcriptional regulator
NKI27_00540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NKI27_00565	COG1178	ABC-type Fe3 transport system permease component
NKI27_00570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NKI27_00575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NKI27_00610	COG0840	transmembrane signaling receptor activity
NKI27_00625	COG1320	monovalent cation:proton antiporter activity
NKI27_00630	COG2212	antiporter activity
NKI27_00635	COG1863	multisubunit Na H antiporter MnhE subunit
NKI27_00640	COG0651	ATP synthesis coupled electron transport
NKI27_00645	COG1006	Multisubunit Na H antiporter MnhC subunit
NKI27_00650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NKI27_00650	COG2111	Na H antiporter
NKI27_00665	COG2909	trisaccharide binding
NKI27_00665	COG2909	trisaccharide binding
NKI27_00675	COG3119	arylsulfatase activity
NKI27_00685	COG2703	oxygen carrier activity
NKI27_00695	COG0545	Peptidyl-prolyl cis-trans isomerase
NKI27_00700	COG0583	DNA-binding transcription factor activity
NKI27_00705	COG1279	arginine transmembrane transporter activity
NKI27_00710	COG2860	membrane
NKI27_00770	COG3420	alginic acid biosynthetic process
NKI27_00820	COG3119	arylsulfatase activity
NKI27_00835	COG0583	DNA-binding transcription factor activity
NKI27_00840	COG1252	NADH dehydrogenase
NKI27_00855	COG0579	oxidoreductase
NKI27_00860	COG1960	acyl-CoA dehydrogenase activity
NKI27_00885	COG1280	lysine exporter protein (LysE YggA)
NKI27_00930	COG2067	long-chain fatty acid transport protein
NKI27_00950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NKI27_00955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NKI27_00955	COG5322	oxidoreductase activity
NKI27_00960	COG1017	nitric oxide dioxygenase activity
NKI27_00960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NKI27_00975	COG0748	coenzyme F420 binding
NKI27_00990	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NKI27_00995	COG0811	peptide transport
NKI27_01000	COG0848	biopolymer transport protein
NKI27_01010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NKI27_01015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NKI27_01030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NKI27_01065	COG0071	Belongs to the small heat shock protein (HSP20) family
NKI27_01070	COG2169	Transcriptional regulator
NKI27_01070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NKI27_01090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NKI27_01100	COG0443	Heat shock 70 kDa protein
NKI27_01130	COG1309	transcriptional regulator
NKI27_01135	COG2095	MarC family integral membrane protein
NKI27_01155	COG2304	oxidoreductase activity
NKI27_01175	COG1902	pentaerythritol trinitrate reductase activity
NKI27_01175	COG0446	pyridine nucleotide-disulphide oxidoreductase
NKI27_01180	COG0668	transmembrane transport
NKI27_01200	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NKI27_01275	COG2217	Heavy metal translocating P-type atpase
NKI27_01280	COG0789	Transcriptional regulator
NKI27_01310	COG1272	protein, Hemolysin III
NKI27_01340	COG1832	CoA-binding protein
NKI27_01345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NKI27_01350	COG0302	gtp cyclohydrolase
NKI27_01365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NKI27_01395	COG0488	(ABC) transporter
NKI27_01400	COG0625	glutathione transferase activity
NKI27_01420	COG3005	denitrification pathway
NKI27_01430	COG0243	molybdopterin cofactor binding
NKI27_01445	COG3850	Histidine kinase
NKI27_01450	COG2197	response regulator
NKI27_01455	COG0746	molybdenum cofactor guanylyltransferase activity
NKI27_01465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NKI27_01470	COG0303	'Molybdopterin
NKI27_01475	COG0521	Mo-molybdopterin cofactor biosynthetic process
NKI27_01490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NKI27_01500	COG3071	HemY protein
NKI27_01505	COG2959	enzyme of heme biosynthesis
NKI27_01515	COG0181	hydroxymethylbilane synthase activity
NKI27_01525	COG3275	phosphorelay sensor kinase activity
NKI27_01530	COG0165	Argininosuccinate lyase
NKI27_01535	COG3706	GGDEF domain
NKI27_01550	COG0019	diaminopimelate decarboxylase activity
NKI27_01555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NKI27_01575	COG2205	protein histidine kinase activity
NKI27_01575	COG0784	Response regulator, receiver
NKI27_01575	COG2198	Histidine kinase
NKI27_01590	COG1120	ATPase activity
NKI27_01600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NKI27_01610	COG3300	MHYT domain
NKI27_01610	COG5001	Diguanylate cyclase
NKI27_01620	COG1752	Esterase of the alpha-beta hydrolase superfamily
NKI27_01660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NKI27_01670	COG0729	surface antigen
NKI27_01675	COG2911	Protein conserved in bacteria
NKI27_01720	COG4335	DNA alkylation repair
NKI27_01735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NKI27_01740	COG1127	ABC transporter
NKI27_01760	COG0069	glutamate synthase activity
NKI27_01785	COG1760	l-serine dehydratase
NKI27_01790	COG0657	acetylesterase activity
NKI27_01805	COG0668	transmembrane transport
NKI27_01840	COG1695	Transcriptional regulator
NKI27_01845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NKI27_01860	COG2183	response to ionizing radiation
NKI27_01865	COG2918	glutathione biosynthetic process
NKI27_01880	COG0840	transmembrane signaling receptor activity
NKI27_01900	COG0204	Acyl-transferase
NKI27_01910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NKI27_01930	COG2201	protein-glutamate methylesterase activity
NKI27_01935	COG2198	Histidine kinase
NKI27_01935	COG0784	Response regulator, receiver
NKI27_01935	COG0643	Histidine kinase
NKI27_01945	COG0840	transmembrane signaling receptor activity
NKI27_01965	COG0189	ligase activity
NKI27_01975	COG1678	Uncharacterized ACR, COG1678
NKI27_01980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NKI27_01990	COG0540	Belongs to the ATCase OTCase family
NKI27_02000	COG2095	MarC family integral membrane protein
NKI27_02035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NKI27_02045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NKI27_02050	COG1011	Hydrolase
NKI27_02065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NKI27_02070	COG0742	ribosomal rna small subunit methyltransferase
NKI27_02080	COG2884	Cell division ATP-binding protein ftsE
NKI27_02085	COG2177	Part of the ABC transporter FtsEX involved in
NKI27_02120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NKI27_02150	COG2205	protein histidine kinase activity
NKI27_02155	COG0745	RESPONSE REGULATOR receiver
NKI27_02160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NKI27_02160	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NKI27_02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NKI27_02190	COG2885	chlorophyll binding
NKI27_02200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NKI27_02215	COG1752	Esterase of the alpha-beta hydrolase superfamily
NKI27_02220	COG2072	flavoprotein involved in K transport
NKI27_02230	COG0210	DNA helicase
NKI27_02250	COG1024	Enoyl-CoA hydratase
NKI27_02255	COG1024	Enoyl-CoA hydratase
NKI27_02260	COG1960	acyl-CoA dehydrogenase activity
NKI27_02275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NKI27_02290	COG1611	Belongs to the LOG family
NKI27_02295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NKI27_02295	COG0301	tRNA thio-modification
NKI27_02315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NKI27_02340	COG1454	alcohol dehydrogenase
NKI27_02350	COG0697	spore germination
NKI27_02355	COG0784	Response regulator, receiver
NKI27_02355	COG3437	response regulator, receiver
NKI27_02365	COG0686	Belongs to the AlaDH PNT family
NKI27_02375	COG0604	alcohol dehydrogenase
NKI27_02380	COG0668	transmembrane transport
NKI27_02405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NKI27_02405	COG0519	Catalyzes the synthesis of GMP from XMP
NKI27_02410	COG0395	ABC-type sugar transport system, permease component
NKI27_02420	COG3842	ATPase activity
NKI27_02425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NKI27_02430	COG2315	Protein conserved in bacteria
NKI27_02435	COG1794	racemase activity, acting on amino acids and derivatives
NKI27_02440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NKI27_02470	COG0210	DNA helicase
NKI27_02475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NKI27_02490	COG2831	hemolysin activation secretion protein
NKI27_02495	COG3210	domain, Protein
NKI27_02540	COG0318	PFAM AMP-dependent synthetase and ligase
NKI27_02575	COG3118	belongs to the thioredoxin family
NKI27_02585	COG0435	Glutathione S-transferase
NKI27_02600	COG1272	protein, Hemolysin III
NKI27_02605	COG5002	protein histidine kinase activity
NKI27_02610	COG0745	RESPONSE REGULATOR receiver
NKI27_02615	COG2205	protein histidine kinase activity
NKI27_02620	COG0745	RESPONSE REGULATOR receiver
NKI27_02635	COG0134	indole-3-glycerol-phosphate synthase activity
NKI27_02640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NKI27_02655	COG0546	phosphoglycolate phosphatase activity
NKI27_02660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NKI27_02670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NKI27_02675	COG3178	'Phosphotransferase
NKI27_02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NKI27_02685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NKI27_02690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NKI27_02695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NKI27_02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NKI27_02705	COG2363	Small membrane protein
NKI27_02715	COG2022	thiamine diphosphate biosynthetic process
NKI27_02720	COG1309	transcriptional regulator
NKI27_02740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NKI27_02750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NKI27_02755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NKI27_02760	COG1605	Chorismate mutase
NKI27_02760	COG0077	Prephenate dehydratase
NKI27_02780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NKI27_02790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NKI27_02790	COG0678	peroxiredoxin activity
NKI27_02800	COG0786	glutamate:sodium symporter activity
NKI27_02840	COG0829	nickel cation binding
NKI27_02845	COG0831	urea catabolic process
NKI27_02850	COG0832	Belongs to the urease beta subunit family
NKI27_02855	COG0804	urea catabolic process
NKI27_02860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NKI27_02865	COG0830	nickel cation binding
NKI27_02870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NKI27_02885	COG0151	Belongs to the GarS family
NKI27_02910	COG2264	protein methyltransferase activity
NKI27_02920	COG0511	ligase activity, forming carbon-carbon bonds
NKI27_02925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NKI27_02935	COG5001	Diguanylate cyclase
NKI27_02935	COG3300	MHYT domain
NKI27_02950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NKI27_02965	COG4263	nitrous-oxide reductase activity
NKI27_02970	COG0348	domain, Protein
NKI27_02970	COG3901	Regulator of nitric oxide reductase transcription
NKI27_02985	COG1960	acyl-CoA dehydrogenase activity
NKI27_02995	COG0784	Response regulator, receiver
NKI27_02995	COG2205	protein histidine kinase activity
NKI27_03010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NKI27_03040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NKI27_03045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NKI27_03050	COG2814	Major facilitator Superfamily
NKI27_03070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NKI27_03080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NKI27_03105	COG0006	proline dipeptidase activity
NKI27_03110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NKI27_03115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NKI27_03125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NKI27_03135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NKI27_03140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NKI27_03145	COG0140	phosphoribosyl-ATP diphosphatase activity
NKI27_03150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NKI27_03155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NKI27_03165	COG2226	methyltransferase
NKI27_03175	COG0318	PFAM AMP-dependent synthetase and ligase
NKI27_03225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NKI27_03230	COG3268	Saccharopine dehydrogenase
NKI27_03310	COG0784	Response regulator, receiver
NKI27_03310	COG2198	Histidine kinase
NKI27_03310	COG5002	protein histidine kinase activity
NKI27_03325	COG0514	ATP-dependent DNA helicase (RecQ)
NKI27_03335	COG2205	protein histidine kinase activity
NKI27_03345	COG2205	protein histidine kinase activity
NKI27_03355	COG2204	response regulator
NKI27_03375	COG0789	Transcriptional regulator
NKI27_03380	COG1090	epimerase
NKI27_03390	COG3706	GGDEF domain
NKI27_03420	COG1104	cysteine desulfurase activity
NKI27_03440	COG0556	nucleotide-excision repair
NKI27_03500	COG0028	Belongs to the TPP enzyme family
NKI27_03520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NKI27_03525	COG0733	neurotransmitter:sodium symporter activity
NKI27_03535	COG2914	Belongs to the UPF0125 (RnfH) family
NKI27_03550	COG0497	DNA recombination
NKI27_03555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NKI27_03560	COG0443	Heat shock 70 kDa protein
NKI27_03565	COG0484	heat shock protein binding
NKI27_03570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NKI27_03575	COG0505	Belongs to the CarA family
NKI27_03595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NKI27_03600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NKI27_03605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NKI27_03610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NKI27_03615	COG0149	triose-phosphate isomerase activity
NKI27_03620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NKI27_03630	COG0779	Required for maturation of 30S ribosomal subunits
NKI27_03635	COG0195	Participates in both transcription termination and antitermination
NKI27_03640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NKI27_03640	COG3064	Membrane
NKI27_03645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NKI27_03650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NKI27_03655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NKI27_03660	COG1185	polyribonucleotide nucleotidyltransferase activity
NKI27_03665	COG1073	alpha beta
NKI27_03745	COG1454	alcohol dehydrogenase
NKI27_03750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NKI27_03785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NKI27_03785	COG1199	ATP-dependent helicase activity
NKI27_03830	COG4191	Histidine kinase
NKI27_03835	COG0784	Response regulator, receiver
NKI27_03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NKI27_03850	COG0557	exoribonuclease II activity
NKI27_03855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NKI27_03860	COG0360	Binds together with S18 to 16S ribosomal RNA
NKI27_03865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NKI27_03875	COG0359	binds to the 23S rRNA
NKI27_03880	COG0305	Participates in initiation and elongation during chromosome replication
NKI27_03885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NKI27_03895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NKI27_03925	COG5001	Diguanylate cyclase
NKI27_03925	COG3300	MHYT domain
NKI27_03945	COG0405	Gamma-glutamyltransferase
NKI27_03995	COG3239	Fatty acid desaturase
NKI27_04000	COG2871	sodium ion transport
NKI27_04020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NKI27_04080	COG0515	serine threonine protein kinase
NKI27_04105	COG1201	RNA secondary structure unwinding
NKI27_04160	COG0012	GTP binding
NKI27_04165	COG0193	aminoacyl-tRNA hydrolase activity
NKI27_04170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NKI27_04175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NKI27_04185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NKI27_04190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NKI27_04200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NKI27_04205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NKI27_04210	COG2890	protein-(glutamine-N5) methyltransferase activity
NKI27_04215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NKI27_04230	COG0583	DNA-binding transcription factor activity
NKI27_04235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NKI27_04255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NKI27_04260	COG2894	cell division
NKI27_04265	COG0850	regulation of cytokinetic process
NKI27_04270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NKI27_04280	COG0560	Phosphoserine phosphatase
NKI27_04280	COG3830	Belongs to the UPF0237 family
NKI27_04285	COG2200	EAL domain
NKI27_04295	COG1509	lysine 2,3-aminomutase activity
NKI27_04300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NKI27_04305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NKI27_04310	COG0688	phosphatidylethanolamine metabolic process
NKI27_04335	COG1162	GTPase activity
NKI27_04340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NKI27_04350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NKI27_04350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NKI27_04355	COG0802	atpase or kinase
NKI27_04360	COG0860	N-Acetylmuramoyl-L-alanine amidase
NKI27_04365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NKI27_04370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NKI27_04375	COG1923	regulation of RNA biosynthetic process
NKI27_04380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NKI27_04385	COG0330	HflC and HflK could
NKI27_04390	COG0330	HflC and HflK could
NKI27_04400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NKI27_04405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NKI27_04410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NKI27_04415	COG4106	trans-aconitate 2-methyltransferase activity
NKI27_04450	COG0579	oxidoreductase
NKI27_04455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NKI27_04470	COG1012	belongs to the aldehyde dehydrogenase family
NKI27_04475	COG3724	N-succinylarginine dihydrolase activity
NKI27_04480	COG2988	succinylglutamate desuccinylase activity
NKI27_04485	COG4160	amino acid transport
NKI27_04535	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NKI27_04540	COG4251	negative regulation of phosphorylation
NKI27_04540	COG5001	Diguanylate cyclase
NKI27_04540	COG2203	Gaf domain
NKI27_04540	COG3706	GGDEF domain
NKI27_04545	COG1194	a g-specific adenine glycosylase
NKI27_04560	COG0131	Imidazoleglycerol-phosphate dehydratase
NKI27_04565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NKI27_04570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NKI27_04575	COG0107	imidazoleglycerol-phosphate synthase activity
NKI27_04585	COG2861	carbohydrate metabolic process
NKI27_04595	COG4942	peptidase
NKI27_04600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NKI27_04605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NKI27_04615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NKI27_04620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NKI27_04625	COG0183	Belongs to the thiolase family
NKI27_04650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NKI27_04660	COG1960	acyl-CoA dehydrogenase activity
NKI27_04675	COG2223	nitrite transmembrane transporter activity
NKI27_04680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NKI27_04685	COG2233	PERMEase
NKI27_04690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NKI27_04715	COG2193	ferroxidase activity
NKI27_04725	COG1116	anion transmembrane transporter activity
NKI27_04730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NKI27_04750	COG1120	ATPase activity
NKI27_04755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NKI27_04780	COG4774	siderophore transport
NKI27_04800	COG0848	biopolymer transport protein
NKI27_04805	COG0811	peptide transport
NKI27_04810	COG0811	peptide transport
NKI27_04845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NKI27_04865	COG0716	FMN binding
NKI27_04875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NKI27_04880	COG0156	8-amino-7-oxononanoate synthase activity
NKI27_04885	COG1073	alpha beta
NKI27_04885	COG2226	methyltransferase
NKI27_04890	COG2226	methyltransferase
NKI27_04890	COG1073	alpha beta
NKI27_04895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NKI27_04910	COG1960	acyl-CoA dehydrogenase activity
NKI27_04915	COG1960	acyl-CoA dehydrogenase activity
NKI27_04925	COG1466	dna polymerase III delta subunit
NKI27_04935	COG0495	leucyl-tRNA aminoacylation
NKI27_04950	COG4535	Mg2 and Co2 transporter CorC
NKI27_04955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NKI27_04960	COG1702	phosphate starvation-inducible protein PhoH
NKI27_04975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NKI27_04980	COG0583	DNA-binding transcription factor activity
NKI27_04990	COG2130	NADP-dependent
NKI27_05000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NKI27_05005	COG0513	Belongs to the DEAD box helicase family
NKI27_05015	COG3769	mannosylglycerate metabolic process
NKI27_05020	COG1215	transferase activity, transferring glycosyl groups
NKI27_05025	COG0366	Alpha amylase catalytic
NKI27_05045	COG3081	Nucleoid-associated protein
NKI27_05055	COG0175	sulfate reduction
NKI27_05075	COG0736	holo-[acyl-carrier-protein] synthase activity
NKI27_05080	COG2205	protein histidine kinase activity
NKI27_05080	COG5002	protein histidine kinase activity
NKI27_05080	COG0784	Response regulator, receiver
NKI27_05090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NKI27_05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NKI27_05100	COG3956	TIGRFAM MazG family protein
NKI27_05120	COG5001	Diguanylate cyclase
NKI27_05120	COG5002	protein histidine kinase activity
NKI27_05125	COG4251	negative regulation of phosphorylation
NKI27_05135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NKI27_05145	COG0563	adenylate kinase activity
NKI27_05150	COG1214	PFAM Peptidase M22, glycoprotease
NKI27_05155	COG1968	undecaprenyl-diphosphatase activity
NKI27_05165	COG0742	ribosomal rna small subunit methyltransferase
NKI27_05170	COG2937	Belongs to the GPAT DAPAT family
NKI27_05175	COG1131	(ABC) transporter
NKI27_05190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NKI27_05215	COG4191	Histidine kinase
NKI27_05235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NKI27_05260	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_05275	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_05300	COG2205	protein histidine kinase activity
NKI27_05300	COG2198	Histidine kinase
NKI27_05300	COG0784	Response regulator, receiver
NKI27_05310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NKI27_05330	COG2161	toxin-antitoxin pair type II binding
NKI27_05335	COG4115	mRNA cleavage
NKI27_05485	COG4372	Transposase
NKI27_05555	COG4372	Transposase
NKI27_05605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NKI27_05670	COG2072	flavoprotein involved in K transport
NKI27_05830	COG2003	Belongs to the UPF0758 family
NKI27_05855	COG4372	Transposase
NKI27_05870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NKI27_05935	COG2105	PFAM AIG2 family protein
NKI27_05950	COG4372	Transposase
NKI27_06020	COG2026	Addiction module toxin, RelE StbE family
NKI27_06070	COG2161	toxin-antitoxin pair type II binding
NKI27_06075	COG4115	mRNA cleavage
NKI27_06100	COG3041	Addiction module toxin RelE StbE family
NKI27_06125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NKI27_06130	COG2176	DNA-directed DNA polymerase activity
NKI27_06140	COG2840	Smr protein MutS2
NKI27_06150	COG0235	Class ii aldolase
NKI27_06155	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NKI27_06160	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NKI27_06205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NKI27_06220	COG1393	Belongs to the ArsC family
NKI27_06235	COG0754	glutathionylspermidine amidase activity
NKI27_06240	COG5463	Belongs to the UPF0441 family
NKI27_06245	COG3766	membrane
NKI27_06260	COG1842	Phage shock protein A
NKI27_06265	COG3789	protein conserved in bacteria
NKI27_06290	COG0825	malonyl-CoA metabolic process
NKI27_06295	COG0037	tRNA processing
NKI27_06300	COG0504	CTP synthase activity
NKI27_06305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NKI27_06310	COG0148	phosphopyruvate hydratase activity
NKI27_06315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NKI27_06320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NKI27_06325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NKI27_06330	COG0585	pseudouridine synthase activity
NKI27_06335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NKI27_06340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NKI27_06375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NKI27_06390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NKI27_06395	COG4660	Part of a membrane complex involved in electron transport
NKI27_06400	COG4659	FMN binding
NKI27_06405	COG4658	electron transport chain
NKI27_06410	COG4656	Part of a membrane complex involved in electron transport
NKI27_06415	COG2878	Part of a membrane complex involved in electron transport
NKI27_06420	COG4657	Part of a membrane complex involved in electron transport
NKI27_06425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NKI27_06425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NKI27_06430	COG0489	protein tyrosine kinase activity
NKI27_06440	COG2010	Cytochrome c
NKI27_06450	COG3278	Belongs to the heme-copper respiratory oxidase family
NKI27_06460	COG0390	transport system, permease component
NKI27_06465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NKI27_06470	COG0717	Belongs to the dCTP deaminase family
NKI27_06475	COG2814	Major facilitator Superfamily
NKI27_06480	COG0235	Class ii aldolase
NKI27_06490	COG3977	Valine--pyruvate aminotransferase
NKI27_06500	COG2226	methyltransferase
NKI27_06510	COG0534	Mate efflux family protein
NKI27_06515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NKI27_06525	COG1054	Belongs to the UPF0176 family
NKI27_06550	COG2204	response regulator
NKI27_06555	COG3706	GGDEF domain
NKI27_06560	COG1960	acyl-CoA dehydrogenase activity
NKI27_06565	COG1960	acyl-CoA dehydrogenase activity
NKI27_06610	COG3706	GGDEF domain
NKI27_06615	COG2207	Transcriptional regulator
NKI27_06620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NKI27_06625	COG2207	Transcriptional regulator
NKI27_06635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NKI27_06640	COG1070	Carbohydrate kinase
NKI27_06645	COG0745	RESPONSE REGULATOR receiver
NKI27_06650	COG1666	GTP binding
NKI27_06660	COG2814	Major facilitator Superfamily
NKI27_06670	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_06675	COG3030	protein affecting phage T7 exclusion by the F plasmid
NKI27_06680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NKI27_06685	COG0459	protein refolding
NKI27_06705	COG0501	Belongs to the peptidase M48B family
NKI27_06710	COG1704	LemA family
NKI27_06720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NKI27_06730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NKI27_06805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NKI27_06810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NKI27_06815	COG0705	Rhomboid family
NKI27_06830	COG0308	aminopeptidase N
NKI27_06850	COG2358	TRAP transporter, solute receptor (TAXI family
NKI27_06860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NKI27_06865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NKI27_06870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NKI27_06875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NKI27_06880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NKI27_06885	COG0072	phenylalanine-tRNA ligase activity
NKI27_06885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NKI27_06890	COG0776	regulation of translation
NKI27_06915	COG4372	Transposase
NKI27_06980	COG1797	cobyrinic acid a,c-diamide synthase activity
NKI27_06985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NKI27_07045	COG1492	cobalamin metabolic process
NKI27_07050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NKI27_07080	COG0625	glutathione transferase activity
NKI27_07095	COG0514	ATP-dependent DNA helicase (RecQ)
NKI27_07100	COG1322	Protein conserved in bacteria
NKI27_07105	COG5002	protein histidine kinase activity
NKI27_07105	COG5001	Diguanylate cyclase
NKI27_07115	COG0714	Associated with various cellular activities
NKI27_07135	COG1648	precorrin-2 dehydrogenase activity
NKI27_07135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NKI27_07140	COG0535	radical SAM domain protein
NKI27_07170	COG2010	Cytochrome c
NKI27_07195	COG2010	Cytochrome c
NKI27_07230	COG1639	'signal transduction protein
NKI27_07245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NKI27_07255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NKI27_07260	COG5002	protein histidine kinase activity
NKI27_07280	COG0271	Belongs to the BolA IbaG family
NKI27_07285	COG0009	L-threonylcarbamoyladenylate synthase
NKI27_07300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NKI27_07350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NKI27_07385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NKI27_07400	COG0318	PFAM AMP-dependent synthetase and ligase
NKI27_07405	COG0673	inositol 2-dehydrogenase activity
NKI27_07410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NKI27_07445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NKI27_07455	COG0123	including yeast histone deacetylase and acetoin utilization protein
NKI27_07460	COG1042	CoA-binding domain protein
NKI27_07460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NKI27_07460	COG0045	succinate-CoA ligase (ADP-forming) activity
NKI27_07465	COG2974	May be involved in recombination
NKI27_07475	COG3022	response to hydroperoxide
NKI27_07500	COG2304	oxidoreductase activity
NKI27_07520	COG0714	Associated with various cellular activities
NKI27_07540	COG0442	prolyl-tRNA aminoacylation
NKI27_07545	COG1570	exodeoxyribonuclease VII activity
NKI27_07555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NKI27_07555	COG0519	Catalyzes the synthesis of GMP from XMP
NKI27_07595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NKI27_07600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NKI27_07605	COG0632	four-way junction helicase activity
NKI27_07610	COG2255	four-way junction helicase activity
NKI27_07615	COG0824	Thioesterase
NKI27_07635	COG0823	Involved in the tonB-independent uptake of proteins
NKI27_07635	COG5616	cAMP biosynthetic process
NKI27_07640	COG2885	chlorophyll binding
NKI27_07645	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NKI27_07660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NKI27_07670	COG0425	Belongs to the sulfur carrier protein TusA family
NKI27_07685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NKI27_07690	COG2716	regulation of RNA biosynthetic process
NKI27_07695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NKI27_07705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NKI27_07795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NKI27_07805	COG1106	Psort location Cytoplasmic, score
NKI27_07860	COG2827	Endonuclease containing a URI domain
NKI27_07890	COG4804	nuclease activity
NKI27_07990	COG0631	protein serine/threonine phosphatase activity
NKI27_08005	COG4120	Belongs to the binding-protein-dependent transport system permease family
NKI27_08025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NKI27_08030	COG1840	ABC-type Fe3 transport system, periplasmic component
NKI27_08055	COG1131	(ABC) transporter
NKI27_08060	COG0842	Transport permease protein
NKI27_08065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NKI27_08065	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NKI27_08075	COG0778	Nitroreductase
NKI27_08085	COG1815	bacterial-type flagellum-dependent cell motility
NKI27_08095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NKI27_08105	COG4787	bacterial-type flagellum-dependent cell motility
NKI27_08115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NKI27_08120	COG1706	bacterial-type flagellum-dependent cell motility
NKI27_08145	COG1741	Belongs to the pirin family
NKI27_08155	COG1741	Belongs to the pirin family
NKI27_08160	COG1741	Belongs to the pirin family
NKI27_08165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NKI27_08185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NKI27_08190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NKI27_08195	COG0343	queuine tRNA-ribosyltransferase activity
NKI27_08200	COG1862	Preprotein translocase
NKI27_08240	COG0105	UTP biosynthetic process
NKI27_08245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NKI27_08255	COG1426	Protein conserved in bacteria
NKI27_08260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NKI27_08265	COG0124	histidyl-tRNA synthetase
NKI27_08270	COG2976	Protein conserved in bacteria
NKI27_08290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NKI27_08300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NKI27_08330	COG0784	Response regulator, receiver
NKI27_08330	COG0835	chemotaxis
NKI27_08335	COG0633	Ferredoxin
NKI27_08335	COG3217	Mosc domain protein beta barrel domain protein
NKI27_08345	COG0488	(ABC) transporter
NKI27_08355	COG0589	response to stress
NKI27_08370	COG1024	Enoyl-CoA hydratase
NKI27_08370	COG1250	3-hydroxyacyl-CoA dehydrogenase
NKI27_08375	COG0183	Belongs to the thiolase family
NKI27_08400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NKI27_08405	COG1053	succinate dehydrogenase
NKI27_08410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NKI27_08430	COG0045	succinate-CoA ligase (ADP-forming) activity
NKI27_08440	COG0180	Tryptophanyl-tRNA synthetase
NKI27_08445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NKI27_08450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NKI27_08460	COG3706	GGDEF domain
NKI27_08470	COG1196	nuclear chromosome segregation
NKI27_08475	COG3115	cell septum assembly
NKI27_08480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NKI27_08485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NKI27_08485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NKI27_08490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NKI27_08495	COG3706	GGDEF domain
NKI27_08520	COG0835	chemotaxis
NKI27_08520	COG0784	Response regulator, receiver
NKI27_08525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NKI27_08535	COG1595	DNA-templated transcription, initiation
NKI27_08540	COG0415	Belongs to the DNA photolyase family
NKI27_08555	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_08570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NKI27_08585	COG0488	(ABC) transporter
NKI27_08595	COG1960	acyl-CoA dehydrogenase activity
NKI27_08605	COG2133	pyrroloquinoline quinone binding
NKI27_08625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NKI27_08645	COG1959	2 iron, 2 sulfur cluster binding
NKI27_08650	COG1017	nitric oxide dioxygenase activity
NKI27_08650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NKI27_08655	COG2204	response regulator
NKI27_08660	COG3852	Histidine kinase
NKI27_08665	COG1271	oxidase subunit
NKI27_08670	COG1294	oxidase, subunit
NKI27_08675	COG0667	Aldo Keto reductase
NKI27_08680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NKI27_08680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NKI27_08685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NKI27_08690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NKI27_08695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NKI27_08700	COG3100	YcgL domain-containing protein
NKI27_08705	COG2983	Belongs to the UPF0260 family
NKI27_08725	COG0121	glutamine amidotransferase
NKI27_08730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NKI27_08735	COG0542	response to heat
NKI27_08770	COG0811	peptide transport
NKI27_08790	COG2030	dehydratase
NKI27_08795	COG2267	carboxylic ester hydrolase activity
NKI27_08800	COG0318	PFAM AMP-dependent synthetase and ligase
NKI27_08805	COG1643	Atp-dependent helicase
NKI27_08825	COG3409	Peptidoglycan-binding domain 1 protein
NKI27_08825	COG3267	Type II secretory pathway component ExeA
NKI27_08835	COG1199	ATP-dependent helicase activity
NKI27_08845	COG0730	response to heat
NKI27_08925	COG0084	hydrolase, TatD family'
NKI27_08930	COG2267	carboxylic ester hydrolase activity
NKI27_08950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NKI27_08955	COG2814	Major facilitator Superfamily
NKI27_08965	COG3243	poly(R)-hydroxyalkanoic acid synthase
NKI27_08970	COG0583	DNA-binding transcription factor activity
NKI27_08975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NKI27_08980	COG0066	3-isopropylmalate dehydratase activity
NKI27_08985	COG0473	3-isopropylmalate dehydrogenase activity
NKI27_09005	COG0135	phosphoribosylanthranilate isomerase activity
NKI27_09015	COG0159	tryptophan synthase activity
NKI27_09020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NKI27_09025	COG0285	dihydrofolate synthase activity
NKI27_09035	COG1286	toxin biosynthetic process
NKI27_09050	COG1674	ftsk spoiiie
NKI27_09055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NKI27_09060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NKI27_09065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NKI27_09070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NKI27_09075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NKI27_09075	COG1648	precorrin-2 dehydrogenase activity
NKI27_09080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NKI27_09110	COG4172	Belongs to the ABC transporter superfamily
NKI27_09115	COG4239	(ABC) transporter, permease
NKI27_09120	COG4174	ABC transporter (Permease)
NKI27_09125	COG4166	transmembrane transport
NKI27_09130	COG4166	transmembrane transport
NKI27_09140	COG0741	lytic transglycosylase activity
NKI27_09140	COG1388	LysM domain
NKI27_09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NKI27_09170	COG0616	signal peptide processing
NKI27_09185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NKI27_09195	COG0316	Belongs to the HesB IscA family
NKI27_09195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NKI27_09210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NKI27_09215	COG2920	part of a sulfur-relay system
NKI27_09220	COG2168	tRNA wobble position uridine thiolation
NKI27_09225	COG2923	Belongs to the DsrF TusC family
NKI27_09230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NKI27_09260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NKI27_09280	COG0582	viral genome integration into host DNA
NKI27_09290	COG0582	viral genome integration into host DNA
NKI27_09300	COG0582	viral genome integration into host DNA
NKI27_09320	COG1484	DNA-dependent DNA replication
NKI27_09325	COG4584	PFAM Integrase catalytic
NKI27_09350	COG0582	viral genome integration into host DNA
NKI27_09370	COG1451	nucleotide metabolic process
NKI27_09380	COG1979	alcohol dehydrogenase
NKI27_09410	COG2850	peptidyl-arginine hydroxylation
NKI27_09420	COG2915	High frequency lysogenization protein hflD homolog
NKI27_09425	COG0482	sulfurtransferase activity
NKI27_09435	COG1187	pseudouridine synthase activity
NKI27_09445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NKI27_09450	COG0542	response to heat
NKI27_09455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NKI27_09460	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NKI27_09465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NKI27_09470	COG0492	ferredoxin-NADP+ reductase activity
NKI27_09475	COG0714	Associated with various cellular activities
NKI27_09480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NKI27_09485	COG2957	Belongs to the agmatine deiminase family
NKI27_09500	COG4591	ABC-type transport system involved in lipoprotein release permease component
NKI27_09505	COG1136	(ABC) transporter
NKI27_09515	COG0658	competence protein
NKI27_09515	COG2333	competence protein COMEC
NKI27_09520	COG0811	peptide transport
NKI27_09525	COG0848	biopolymer transport protein
NKI27_09530	COG1132	(ABC) transporter
NKI27_09535	COG1663	tetraacyldisaccharide 4'-kinase activity
NKI27_09540	COG2835	tetraacyldisaccharide 4'-kinase activity
NKI27_09545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NKI27_09550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NKI27_09555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NKI27_09565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NKI27_09570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NKI27_09585	COG0489	protein tyrosine kinase activity
NKI27_09600	COG1215	transferase activity, transferring glycosyl groups
NKI27_09605	COG0438	transferase activity, transferring glycosyl groups
NKI27_09615	COG1216	Glycosyl transferase, family 2
NKI27_09615	COG0463	Glycosyl transferase, family 2
NKI27_09620	COG1649	PFAM Uncharacterised BCR, COG1649
NKI27_09620	COG0726	polysaccharide deacetylase
NKI27_09625	COG0438	transferase activity, transferring glycosyl groups
NKI27_09650	COG0110	maltose O-acetyltransferase activity
NKI27_09665	COG1216	Glycosyl transferase, family 2
NKI27_09665	COG0463	Glycosyl transferase, family 2
NKI27_09675	COG1215	transferase activity, transferring glycosyl groups
NKI27_09720	COG2204	response regulator
NKI27_09725	COG4191	Histidine kinase
NKI27_09735	COG0204	Acyl-transferase
NKI27_09740	COG0582	viral genome integration into host DNA
NKI27_09750	COG4453	Protein conserved in bacteria
NKI27_09820	COG2433	Pfam Transposase IS66
NKI27_09895	COG4584	PFAM Integrase catalytic
NKI27_09900	COG1484	DNA-dependent DNA replication
NKI27_09970	COG2433	Pfam Transposase IS66
NKI27_09975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NKI27_10070	COG1401	restriction endodeoxyribonuclease activity
NKI27_10120	COG1309	transcriptional regulator
NKI27_10125	COG0708	Exodeoxyribonuclease III
NKI27_10135	COG2201	protein-glutamate methylesterase activity
NKI27_10145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NKI27_10160	COG1104	cysteine desulfurase activity
NKI27_10190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NKI27_10200	COG4770	biotin carboxylase activity
NKI27_10205	COG1024	Enoyl-CoA hydratase
NKI27_10210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NKI27_10215	COG1960	acyl-CoA dehydrogenase activity
NKI27_10290	COG3409	Peptidoglycan-binding domain 1 protein
NKI27_10290	COG3267	Type II secretory pathway component ExeA
NKI27_10375	COG0419	ATPase involved in DNA repair
NKI27_10385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NKI27_10410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NKI27_10430	COG3174	membrane
NKI27_10435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NKI27_10445	COG0475	glutathione-regulated potassium exporter activity
NKI27_10445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NKI27_10450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NKI27_10460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NKI27_10465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NKI27_10470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NKI27_10500	COG2217	Heavy metal translocating P-type atpase
NKI27_10520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NKI27_10530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NKI27_10565	COG1230	cation diffusion facilitator family transporter
NKI27_10570	COG0789	Transcriptional regulator
NKI27_10595	COG0668	transmembrane transport
NKI27_10605	COG0835	chemotaxis
NKI27_10605	COG0784	Response regulator, receiver
NKI27_10615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NKI27_10665	COG0583	DNA-binding transcription factor activity
NKI27_10670	COG4974	Belongs to the 'phage' integrase family
NKI27_10675	COG2239	Acts as a magnesium transporter
NKI27_10690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NKI27_10695	COG0800	Aldolase
NKI27_10700	COG0129	dihydroxy-acid dehydratase activity
NKI27_10710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NKI27_10715	COG0515	serine threonine protein kinase
NKI27_10715	COG2815	serine threonine protein kinase
NKI27_10720	COG2116	formate transmembrane transporter activity
NKI27_10725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NKI27_10735	COG3128	pkhd-type hydroxylase
NKI27_10740	COG4774	siderophore transport
NKI27_10755	COG0848	biopolymer transport protein
NKI27_10760	COG0811	peptide transport
NKI27_10770	COG1902	pentaerythritol trinitrate reductase activity
NKI27_10770	COG0446	pyridine nucleotide-disulphide oxidoreductase
NKI27_10780	COG0328	RNA-DNA hybrid ribonuclease activity
NKI27_10795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NKI27_10815	COG1960	acyl-CoA dehydrogenase activity
NKI27_10825	COG3383	formate dehydrogenase (NAD+) activity
NKI27_10925	COG1960	acyl-CoA dehydrogenase activity
NKI27_10980	COG1999	signal sequence binding
NKI27_10995	COG0745	RESPONSE REGULATOR receiver
NKI27_11010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NKI27_11015	COG1074	ATP-dependent DNA helicase activity
NKI27_11020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NKI27_11035	COG0564	pseudouridine synthase activity
NKI27_11050	COG5507	3-demethylubiquinone-9 3-methyltransferase
NKI27_11060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NKI27_11065	COG1846	Transcriptional regulator
NKI27_11070	COG0386	Belongs to the glutathione peroxidase family
NKI27_11095	COG0436	Aminotransferase
NKI27_11105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NKI27_11120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NKI27_11130	COG3101	peptidyl-lysine hydroxylation
NKI27_11140	COG0425	Belongs to the sulfur carrier protein TusA family
NKI27_11155	COG0840	transmembrane signaling receptor activity
NKI27_11160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NKI27_11165	COG3278	Belongs to the heme-copper respiratory oxidase family
NKI27_11180	COG2010	Cytochrome c
NKI27_11185	COG0348	domain, Protein
NKI27_11230	COG0037	tRNA processing
NKI27_11235	COG1309	transcriptional regulator
NKI27_11240	COG0484	heat shock protein binding
NKI27_11270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NKI27_11280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NKI27_11285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NKI27_11290	COG0740	serine-type endopeptidase activity
NKI27_11295	COG0544	peptidyl-prolyl cis-trans isomerase activity
NKI27_11320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NKI27_11325	COG0215	cysteine-tRNA ligase activity
NKI27_11330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NKI27_11340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NKI27_11365	COG3321	synthase
NKI27_11365	COG0604	alcohol dehydrogenase
NKI27_11365	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_11375	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
NKI27_11380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NKI27_11385	COG1063	alcohol dehydrogenase
NKI27_11395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NKI27_11395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NKI27_11400	COG1703	isobutyryl-CoA mutase activity
NKI27_11405	COG0604	alcohol dehydrogenase
NKI27_11415	COG0501	Belongs to the peptidase M48B family
NKI27_11420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NKI27_11425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NKI27_11435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NKI27_11440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NKI27_11450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NKI27_11455	COG0416	fatty acid biosynthetic process
NKI27_11460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NKI27_11465	COG1399	metal-binding, possibly nucleic acid-binding protein
NKI27_11470	COG0424	maF-like protein
NKI27_11485	COG0564	pseudouridine synthase activity
NKI27_11490	COG1530	ribonuclease E activity
NKI27_11510	COG0613	PHP domain protein
NKI27_11515	COG2350	Protein conserved in bacteria
NKI27_11530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NKI27_11550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NKI27_11565	COG1803	Methylglyoxal synthase
NKI27_11605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NKI27_11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NKI27_11615	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NKI27_11630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NKI27_11635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NKI27_11645	COG0584	glycerophosphoryl diester phosphodiesterase
NKI27_11650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NKI27_11655	COG2991	Protein conserved in bacteria
NKI27_11660	COG1477	protein flavinylation
NKI27_11665	COG2871	sodium ion transport
NKI27_11670	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NKI27_11675	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NKI27_11685	COG1805	sodium ion transport
NKI27_11690	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NKI27_11700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NKI27_11715	COG0668	transmembrane transport
NKI27_11720	COG1472	Belongs to the glycosyl hydrolase 3 family
NKI27_11735	COG0004	ammonium transporteR
NKI27_11745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NKI27_11745	COG0617	tRNA 3'-terminal CCA addition
NKI27_11745	COG0517	IMP dehydrogenase activity
NKI27_11755	COG0307	riboflavin synthase, alpha
NKI27_11760	COG2813	Specifically methylates the guanine in position
NKI27_11765	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NKI27_11770	COG4628	conserved protein (DUF2132)
NKI27_11775	COG0564	pseudouridine synthase activity
NKI27_11815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NKI27_11820	COG1607	acyl-coa hydrolase
NKI27_11825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NKI27_11830	COG2813	Specifically methylates the guanine in position
NKI27_11845	COG0564	pseudouridine synthase activity
NKI27_11850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NKI27_11855	COG0564	pseudouridine synthase activity
NKI27_11860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NKI27_11895	COG0454	-acetyltransferase
NKI27_11930	COG1278	Cold shock
NKI27_11940	COG2095	MarC family integral membrane protein
NKI27_11945	COG5322	oxidoreductase activity
NKI27_11945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NKI27_11950	COG1022	Amp-dependent synthetase and ligase
NKI27_11965	COG3768	UPF0283 membrane protein
NKI27_11970	COG3106	COG3106 Predicted ATPase
NKI27_12020	COG0385	Bile acid
NKI27_12025	COG2056	Na+-H+ antiporter family
NKI27_12030	COG0583	DNA-binding transcription factor activity
NKI27_12035	COG2259	Doxx family
NKI27_12040	COG1063	alcohol dehydrogenase
NKI27_12050	COG0739	heme binding
NKI27_12080	COG2081	HI0933 family
NKI27_12090	COG0596	Alpha beta hydrolase
NKI27_12095	COG0709	Synthesizes selenophosphate from selenide and ATP
NKI27_12100	COG0778	Nitroreductase
NKI27_12105	COG3012	SEC-C Motif Domain Protein
NKI27_12110	COG2814	Major facilitator Superfamily
NKI27_12120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NKI27_12125	COG2226	methyltransferase
NKI27_12140	COG2824	Alkylphosphonate utilization operon protein PhnA
NKI27_12145	COG5265	(ABC) transporter
NKI27_12150	COG0023	Translation Initiation Factor
NKI27_12160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NKI27_12185	COG2201	protein-glutamate methylesterase activity
NKI27_12190	COG3706	GGDEF domain
NKI27_12195	COG2837	iron assimilation
NKI27_12200	COG0326	Molecular chaperone. Has ATPase activity
NKI27_12235	COG2204	response regulator
NKI27_12290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NKI27_12295	COG4181	ATPase activity
NKI27_12305	COG0429	hydrolase of the alpha beta-hydrolase fold
NKI27_12310	COG0589	response to stress
NKI27_12325	COG1362	aminopeptidase activity
NKI27_12340	COG0116	Belongs to the methyltransferase superfamily
NKI27_12340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NKI27_12345	COG3130	regulation of translation
NKI27_12350	COG0167	dihydroorotate dehydrogenase activity
NKI27_12365	COG0556	nucleotide-excision repair
NKI27_12370	COG0436	Aminotransferase
NKI27_12385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NKI27_12395	COG0776	regulation of translation
NKI27_12410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NKI27_12415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NKI27_12420	COG0077	Prephenate dehydratase
NKI27_12420	COG1605	Chorismate mutase
NKI27_12425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NKI27_12435	COG3706	GGDEF domain
NKI27_12440	COG0788	formyltetrahydrofolate deformylase activity
NKI27_12445	COG2154	pterin-4-alpha-carbinolamine dehydratase
NKI27_12450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NKI27_12450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NKI27_12465	COG0137	argininosuccinate synthase activity
NKI27_12475	COG0418	dihydroorotase activity
NKI27_12480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NKI27_12485	COG0450	alkyl hydroperoxide reductase
NKI27_12490	COG0653	protein targeting
NKI27_12500	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_12515	COG2925	Exonuclease
NKI27_12550	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NKI27_12575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NKI27_12575	COG0047	phosphoribosylformylglycinamidine synthase activity
NKI27_12580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NKI27_12585	COG2137	regulation of response to DNA damage stimulus
NKI27_12600	COG0183	Belongs to the thiolase family
NKI27_12605	COG1024	Enoyl-CoA hydratase
NKI27_12605	COG1250	3-hydroxyacyl-CoA dehydrogenase
NKI27_12625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NKI27_12630	COG0402	S-adenosylhomocysteine deaminase activity
NKI27_12635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NKI27_12640	COG0546	phosphoglycolate phosphatase activity
NKI27_12645	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_12650	COG4235	cytochrome complex assembly
NKI27_12655	COG3088	subunit of a heme lyase
NKI27_12670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NKI27_12690	COG4133	protoheme IX ABC transporter activity
NKI27_12710	COG2203	Gaf domain
NKI27_12710	COG5001	Diguanylate cyclase
NKI27_12710	COG4251	negative regulation of phosphorylation
NKI27_12710	COG3706	GGDEF domain
NKI27_12720	COG0835	chemotaxis
NKI27_12730	COG1192	Involved in chromosome partitioning
NKI27_12735	COG1360	Flagellar Motor Protein
NKI27_12745	COG2201	protein-glutamate methylesterase activity
NKI27_12750	COG2198	Histidine kinase
NKI27_12750	COG0784	Response regulator, receiver
NKI27_12750	COG0643	Histidine kinase
NKI27_12755	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NKI27_12780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NKI27_12795	COG1987	bacterial-type flagellum assembly
NKI27_12845	COG2201	protein-glutamate methylesterase activity
NKI27_12850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NKI27_12855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NKI27_12860	COG0835	chemotaxis
NKI27_12865	COG2198	Histidine kinase
NKI27_12865	COG0643	Histidine kinase
NKI27_12870	COG0745	RESPONSE REGULATOR receiver
NKI27_12905	COG1677	Flagellar hook-basal body complex protein FliE
NKI27_12935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NKI27_12945	COG3630	sodium ion export across plasma membrane
NKI27_12965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NKI27_12970	COG0527	aspartate kinase activity
NKI27_12975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NKI27_12995	COG0795	lipopolysaccharide-transporting ATPase activity
NKI27_13000	COG0795	lipopolysaccharide-transporting ATPase activity
NKI27_13005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NKI27_13020	COG0525	valine-tRNA ligase activity
NKI27_13050	COG1940	carbohydrate kinase activity
NKI27_13060	COG3725	Membrane protein required for beta-lactamase induction
NKI27_13065	COG3023	N-Acetylmuramoyl-L-alanine amidase
NKI27_13100	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NKI27_13105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NKI27_13110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NKI27_13120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NKI27_13125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NKI27_13135	COG1643	Atp-dependent helicase
NKI27_13150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NKI27_13175	COG0204	Acyl-transferase
NKI27_13205	COG1785	Belongs to the alkaline phosphatase family
NKI27_13240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NKI27_13255	COG4771	TonB-dependent receptor
NKI27_13285	COG1573	uracil-dna glycosylase
NKI27_13290	COG0183	Belongs to the thiolase family
NKI27_13310	COG3153	acetyltransferase
NKI27_13310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NKI27_13320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NKI27_13325	COG0372	Belongs to the citrate synthase family
NKI27_13330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NKI27_13340	COG0826	peptidase U32
NKI27_13365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NKI27_13370	COG4191	Histidine kinase
NKI27_13375	COG4566	intracellular signal transduction
NKI27_13380	COG0739	heme binding
NKI27_13390	COG1067	ATP-dependent peptidase activity
NKI27_13420	COG0826	peptidase U32
NKI27_13425	COG0826	peptidase U32
NKI27_13430	COG1242	4 iron, 4 sulfur cluster binding
NKI27_13435	COG3154	lipid carrier protein
NKI27_13445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NKI27_13450	COG0439	Biotin carboxylase
NKI27_13455	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NKI27_13465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NKI27_13480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NKI27_13485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NKI27_13490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NKI27_13500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NKI27_13505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NKI27_13510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NKI27_13515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NKI27_13535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NKI27_13545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NKI27_13550	COG0233	cytoplasmic translational termination
NKI27_13555	COG0528	UMP kinase activity
NKI27_13560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NKI27_13565	COG0052	Belongs to the universal ribosomal protein uS2 family
NKI27_13570	COG0024	Methionine aminopeptidase
NKI27_13580	COG0436	Aminotransferase
NKI27_13585	COG1393	Belongs to the ArsC family
NKI27_13590	COG2171	N-acyltransferase activity
NKI27_13595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NKI27_13600	COG2226	methyltransferase
NKI27_13615	COG1278	Cold shock
NKI27_13620	COG2900	Belongs to the SlyX family
NKI27_13675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NKI27_13700	COG1086	Polysaccharide biosynthesis protein
NKI27_13720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NKI27_13765	COG1442	glycosyl transferase family 8
NKI27_13765	COG1216	Glycosyl transferase, family 2
NKI27_13775	COG0463	Glycosyl transferase, family 2
NKI27_13785	COG1134	teichoic acid transport
NKI27_13815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NKI27_13835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NKI27_13850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NKI27_13860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NKI27_13865	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NKI27_13870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NKI27_13920	COG1073	alpha beta
NKI27_13920	COG2226	methyltransferase
NKI27_13950	COG0463	Glycosyl transferase, family 2
NKI27_14005	COG0237	dephospho-CoA kinase activity
NKI27_14010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NKI27_14020	COG1380	Effector of murein hydrolase LrgA
NKI27_14025	COG1346	cytolysis
NKI27_14030	COG1720	tRNA m6t6A37 methyltransferase activity
NKI27_14045	COG2205	protein histidine kinase activity
NKI27_14045	COG5002	protein histidine kinase activity
NKI27_14045	COG0784	Response regulator, receiver
NKI27_14050	COG0640	Transcriptional regulator
NKI27_14085	COG2197	response regulator
NKI27_14100	COG0183	Belongs to the thiolase family
NKI27_14105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NKI27_14125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NKI27_14130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NKI27_14135	COG5007	Belongs to the BolA IbaG family
NKI27_14155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NKI27_14160	COG1127	ABC transporter
NKI27_14185	COG1137	ATPase activity
NKI27_14205	COG1660	Displays ATPase and GTPase activities
NKI27_14210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NKI27_14215	COG2239	Acts as a magnesium transporter
NKI27_14220	COG3028	Belongs to the UPF0307 family
NKI27_14225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NKI27_14235	COG1530	ribonuclease E activity
NKI27_14240	COG0424	maF-like protein
NKI27_14245	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NKI27_14250	COG1792	Involved in formation and maintenance of cell shape
NKI27_14255	COG1077	Cell shape determining protein MreB Mrl
NKI27_14260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NKI27_14265	COG0154	amidase activity
NKI27_14270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NKI27_14275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NKI27_14280	COG1381	Involved in DNA repair and RecF pathway recombination
NKI27_14285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NKI27_14290	COG0571	ribonuclease III activity
NKI27_14300	COG0681	Belongs to the peptidase S26 family
NKI27_14305	COG0481	GTPase activity
NKI27_14315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NKI27_14365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NKI27_14375	COG0824	Thioesterase
NKI27_14380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NKI27_14400	COG0335	large ribosomal subunit rRNA binding
NKI27_14410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NKI27_14415	COG0228	four-way junction DNA binding
NKI27_14420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NKI27_14430	COG4536	flavin adenine dinucleotide binding
NKI27_14445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NKI27_14450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NKI27_14455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NKI27_14460	COG3842	ATPase activity
NKI27_14465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NKI27_14480	COG2205	protein histidine kinase activity
NKI27_14485	COG0745	RESPONSE REGULATOR receiver
NKI27_14490	COG1047	Peptidyl-prolyl cis-trans
NKI27_14520	COG2353	YceI-like domain
NKI27_14525	COG3038	cytochrome b561
NKI27_14530	COG2199	diguanylate cyclase activity
NKI27_14530	COG2200	EAL domain
NKI27_14540	COG3091	SprT-like family
NKI27_14545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NKI27_14550	COG2816	NAD+ diphosphatase activity
NKI27_14575	COG3228	Belongs to the MtfA family
NKI27_14585	COG0417	DNA replication proofreading
NKI27_14600	COG4628	conserved protein (DUF2132)
NKI27_14615	COG0488	(ABC) transporter
NKI27_14620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NKI27_14635	COG0523	cobalamin synthesis protein
NKI27_14650	COG0840	transmembrane signaling receptor activity
NKI27_14670	COG0697	spore germination
NKI27_14675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NKI27_14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NKI27_14710	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NKI27_14725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NKI27_14740	COG0741	lytic transglycosylase activity
NKI27_14760	COG0789	Transcriptional regulator
NKI27_14765	COG0484	heat shock protein binding
NKI27_14780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NKI27_14805	COG1280	lysine exporter protein (LysE YggA)
NKI27_14870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NKI27_14875	COG1187	pseudouridine synthase activity
NKI27_14880	COG0513	Belongs to the DEAD box helicase family
NKI27_14900	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NKI27_14905	COG0204	Acyl-transferase
NKI27_14920	COG1061	Type III restriction enzyme res subunit
NKI27_14960	COG0420	3'-5' exonuclease activity
NKI27_14965	COG0419	ATPase involved in DNA repair
NKI27_14980	COG0513	Belongs to the DEAD box helicase family
NKI27_14985	COG0545	Peptidyl-prolyl cis-trans isomerase
NKI27_15000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NKI27_15015	COG1132	(ABC) transporter
NKI27_15035	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NKI27_15045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NKI27_15055	COG0668	transmembrane transport
NKI27_15085	COG3437	response regulator, receiver
NKI27_15085	COG3850	Histidine kinase
NKI27_15085	COG4999	Histidine kinase
NKI27_15085	COG2205	protein histidine kinase activity
NKI27_15090	COG1309	transcriptional regulator
NKI27_15100	COG1028	Short-chain dehydrogenase reductase Sdr
NKI27_15105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NKI27_15110	COG1960	acyl-CoA dehydrogenase activity
NKI27_15115	COG1024	Enoyl-CoA hydratase
NKI27_15140	COG0583	DNA-binding transcription factor activity
NKI27_15150	COG0189	ligase activity
NKI27_15160	COG4067	protein conserved in archaea
NKI27_15160	COG0189	ligase activity
NKI27_15165	COG1376	ErfK ybiS ycfS ynhG family protein
NKI27_15175	COG2252	PERMEase
NKI27_15180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NKI27_15200	COG2885	chlorophyll binding
NKI27_15210	COG2239	Acts as a magnesium transporter
NKI27_15230	COG1285	pathogenesis
NKI27_15235	COG1187	pseudouridine synthase activity
NKI27_15245	COG0179	Fumarylacetoacetate (FAA) hydrolase
NKI27_15250	COG0277	FAD linked oxidase domain protein
NKI27_15255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NKI27_15260	COG2885	chlorophyll binding
NKI27_15270	COG0513	Belongs to the DEAD box helicase family
NKI27_15275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NKI27_15275	COG3264	Mechanosensitive ion channel
NKI27_15290	COG0191	fructose-bisphosphate aldolase activity
NKI27_15295	COG0126	phosphoglycerate kinase activity
NKI27_15300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NKI27_15305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NKI27_15340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NKI27_15345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NKI27_15350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NKI27_15355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NKI27_15360	COG1566	PFAM secretion protein HlyD family protein
NKI27_15395	COG4399	Belongs to the UPF0754 family
NKI27_15415	COG2766	serine protein kinase
NKI27_15420	COG2718	Belongs to the UPF0229 family
NKI27_15425	COG2719	SpoVR family
NKI27_15440	COG0719	Fe-S assembly protein
NKI27_15445	COG0396	ATPase activity
NKI27_15450	COG0719	Fe-S assembly protein
NKI27_15455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NKI27_15460	COG0316	Belongs to the HesB IscA family
NKI27_15470	COG2166	iron-sulfur cluster assembly
NKI27_15490	COG0205	6-phosphofructokinase activity
NKI27_15520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NKI27_15525	COG1309	transcriptional regulator
NKI27_15565	COG0583	DNA-binding transcription factor activity
NKI27_15570	COG0439	Biotin carboxylase
NKI27_15575	COG0511	ligase activity, forming carbon-carbon bonds
NKI27_15575	COG5016	pyruvate
NKI27_15580	COG0288	reversible hydration of carbon dioxide
NKI27_15585	COG0500	methyltransferase
NKI27_15590	COG2314	TM2 domain
NKI27_15595	COG3152	Membrane
NKI27_15605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NKI27_15615	COG4807	Protein conserved in bacteria
NKI27_15665	COG0500	methyltransferase
NKI27_15670	COG0583	DNA-binding transcription factor activity
NKI27_15685	COG0515	serine threonine protein kinase
NKI27_15685	COG2815	serine threonine protein kinase
NKI27_15690	COG2223	nitrite transmembrane transporter activity
NKI27_15695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NKI27_15705	COG0243	molybdopterin cofactor binding
NKI27_15710	COG0346	lactoylglutathione lyase activity
NKI27_15725	COG0569	domain protein
NKI27_15725	COG0189	ligase activity
NKI27_15745	COG1187	pseudouridine synthase activity
NKI27_15750	COG0217	transcriptional regulatory protein
NKI27_15760	COG0668	transmembrane transport
NKI27_15790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NKI27_15810	COG0321	lipoyl(octanoyl) transferase activity
NKI27_15815	COG2921	Belongs to the UPF0250 family
NKI27_15825	COG1686	Belongs to the peptidase S11 family
NKI27_15830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NKI27_15835	COG2951	lytic endotransglycosylase activity
NKI27_15840	COG0772	Belongs to the SEDS family
NKI27_15845	COG0768	penicillin binding
NKI27_15850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NKI27_15860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NKI27_15865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NKI27_15880	COG0586	Pfam SNARE associated Golgi protein
NKI27_15885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NKI27_15895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NKI27_15905	COG0129	dihydroxy-acid dehydratase activity
NKI27_15910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NKI27_15915	COG0840	transmembrane signaling receptor activity
NKI27_15915	COG0840	transmembrane signaling receptor activity
NKI27_15920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NKI27_15925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NKI27_15930	COG0730	response to heat
NKI27_15950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NKI27_15960	COG0142	geranyltranstransferase activity
NKI27_15965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NKI27_15970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NKI27_15975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NKI27_15985	COG0352	thiamine-phosphate diphosphorylase activity
NKI27_15990	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NKI27_15995	COG0653	protein targeting
NKI27_16000	COG0739	heme binding
NKI27_16010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NKI27_16030	COG1181	Belongs to the D-alanine--D-alanine ligase family
NKI27_16035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NKI27_16040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NKI27_16045	COG0772	Belongs to the SEDS family
NKI27_16050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NKI27_16055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NKI27_16060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NKI27_16065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NKI27_16080	COG0275	rRNA processing
NKI27_16085	COG2001	Belongs to the MraZ family
NKI27_16095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NKI27_16100	COG3107	peptidoglycan biosynthetic process
NKI27_16105	COG0792	nuclease activity
NKI27_16110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NKI27_16115	COG2969	positive regulation of protein catabolic process
NKI27_16120	COG0625	glutathione transferase activity
NKI27_16125	COG2857	Cytochrome c1
NKI27_16130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NKI27_16135	COG0723	plastoquinol--plastocyanin reductase activity
NKI27_16140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NKI27_16145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NKI27_16150	COG0084	hydrolase, TatD family'
NKI27_16155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NKI27_16160	COG4191	Histidine kinase
NKI27_16165	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NKI27_16170	COG0456	acetyltransferase
NKI27_16180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NKI27_16205	COG1183	phosphatidylcholine synthase activity
NKI27_16215	COG0028	Belongs to the TPP enzyme family
NKI27_16245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NKI27_16245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NKI27_16260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NKI27_16305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NKI27_16310	COG1047	Peptidyl-prolyl cis-trans
NKI27_16320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NKI27_16325	COG0196	riboflavin kinase activity
NKI27_16330	COG0728	peptidoglycan biosynthetic process
NKI27_16335	COG0268	Binds directly to 16S ribosomal RNA
NKI27_16340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NKI27_16345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NKI27_16350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NKI27_16355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NKI27_16360	COG0142	geranyltranstransferase activity
NKI27_16380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NKI27_16390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NKI27_16395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NKI27_16410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NKI27_16410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NKI27_16415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NKI27_16420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NKI27_16425	COG0488	(ABC) transporter
NKI27_16445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NKI27_16450	COG0493	'glutamate synthase
NKI27_16455	COG0067	glutamate synthase
NKI27_16455	COG0069	glutamate synthase activity
NKI27_16455	COG0070	glutamate synthase
NKI27_16465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NKI27_16470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NKI27_16525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NKI27_16540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NKI27_16545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NKI27_16570	COG0628	permease
NKI27_16575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NKI27_16605	COG1444	tRNA N-acetyltransferase activity
NKI27_16615	COG1960	acyl-CoA dehydrogenase activity
NKI27_16620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NKI27_16645	COG0076	glutamate decarboxylase activity
NKI27_16660	COG5001	Diguanylate cyclase
NKI27_16660	COG2203	Gaf domain
NKI27_16660	COG3706	GGDEF domain
NKI27_16660	COG4251	negative regulation of phosphorylation
NKI27_16665	COG0306	phosphate transporter
NKI27_16685	COG1946	Acyl-CoA thioesterase
NKI27_16710	COG3161	chorismate lyase activity
NKI27_16715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NKI27_16740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NKI27_16745	COG1119	ATPase activity
NKI27_16750	COG0745	RESPONSE REGULATOR receiver
NKI27_16780	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NKI27_16785	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NKI27_16790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NKI27_16795	COG3639	organic phosphonate transmembrane transporter activity
NKI27_16800	COG0709	Synthesizes selenophosphate from selenide and ATP
NKI27_16805	COG0668	transmembrane transport
NKI27_16815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NKI27_16820	COG0537	adenosine 5'-monophosphoramidase activity
NKI27_16835	COG0704	Plays a role in the regulation of phosphate uptake
NKI27_16840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NKI27_16845	COG0581	inorganic phosphate transmembrane transporter activity
NKI27_16870	COG1607	acyl-coa hydrolase
NKI27_16885	COG1765	OsmC-like protein
NKI27_16895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NKI27_16900	COG3954	Phosphoribulokinase
NKI27_16905	COG5001	Diguanylate cyclase
NKI27_16905	COG5002	protein histidine kinase activity
NKI27_16915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NKI27_16915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NKI27_16920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NKI27_16930	COG3706	GGDEF domain
NKI27_16935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NKI27_16945	COG0756	dUTP diphosphatase activity
NKI27_16950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NKI27_16955	COG2003	Belongs to the UPF0758 family
NKI27_16960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NKI27_16965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NKI27_16970	COG0281	malic enzyme
NKI27_16980	COG0254	rRNA binding
NKI27_16985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NKI27_16990	COG0018	arginyl-trna synthetase
NKI27_17000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NKI27_17005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NKI27_17020	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NKI27_17025	COG0494	nUDIX hydrolase
NKI27_17045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NKI27_17050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NKI27_17060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NKI27_17065	COG3150	esterase
NKI27_17070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NKI27_17080	COG0494	nUDIX hydrolase
NKI27_17085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NKI27_17090	COG1538	Outer membrane efflux protein
NKI27_17095	COG1519	Transferase
NKI27_17125	COG0438	transferase activity, transferring glycosyl groups
NKI27_17130	COG0438	transferase activity, transferring glycosyl groups
NKI27_17140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NKI27_17175	COG3025	triphosphatase activity
NKI27_17185	COG1490	D-aminoacyl-tRNA deacylase activity
NKI27_17195	COG1217	gtp-binding protein TYPA
NKI27_17200	COG0174	glutamine synthetase
NKI27_17210	COG3852	Histidine kinase
NKI27_17215	COG2204	response regulator
NKI27_17250	COG2165	general secretion pathway protein
NKI27_17260	COG1459	type II secretion system
NKI27_17265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NKI27_17275	COG3267	Type II secretory pathway component ExeA
NKI27_17275	COG3409	Peptidoglycan-binding domain 1 protein
NKI27_17280	COG1450	Type ii and iii secretion system protein
NKI27_17315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NKI27_17325	COG1917	Cupin 2, conserved barrel domain protein
NKI27_17330	COG0527	aspartate kinase activity
NKI27_17345	COG1882	Formate acetyltransferase
NKI27_17350	COG1882	Formate acetyltransferase
NKI27_17370	COG2814	Major facilitator Superfamily
NKI27_17380	COG0203	ribosomal protein L17
NKI27_17385	COG0202	RNA polymerase activity
NKI27_17390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NKI27_17395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NKI27_17400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NKI27_17405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NKI27_17415	COG0200	Binds to the 23S rRNA
NKI27_17420	COG1841	ribosomal large subunit assembly
NKI27_17425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NKI27_17430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NKI27_17435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NKI27_17440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NKI27_17445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NKI27_17450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NKI27_17455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NKI27_17460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NKI27_17465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NKI27_17470	COG0255	Belongs to the universal ribosomal protein uL29 family
NKI27_17475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NKI27_17480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NKI27_17485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NKI27_17490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NKI27_17495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NKI27_17500	COG0089	rRNA binding
NKI27_17505	COG0088	Forms part of the polypeptide exit tunnel
NKI27_17510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NKI27_17515	COG0051	transcription antitermination factor activity, RNA binding
NKI27_17520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NKI27_17525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NKI27_17530	COG0049	tRNA binding
NKI27_17535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NKI27_17540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NKI27_17545	COG0085	RNA polymerase activity
NKI27_17550	COG0222	ribosome binding
NKI27_17555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NKI27_17560	COG0081	regulation of translation
NKI27_17565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NKI27_17610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NKI27_17665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NKI27_17670	COG0739	heme binding
NKI27_17680	COG0316	Belongs to the HesB IscA family
NKI27_17695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NKI27_17705	COG1981	membrane
NKI27_17710	COG0352	thiamine-phosphate diphosphorylase activity
NKI27_17710	COG0351	phosphomethylpyrimidine kinase
NKI27_17715	COG0352	thiamine-phosphate diphosphorylase activity
NKI27_17720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NKI27_17730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NKI27_17760	COG1489	DNA binding
NKI27_17765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NKI27_17770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NKI27_17775	COG4191	Histidine kinase
NKI27_17780	COG2204	response regulator
NKI27_17790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NKI27_17795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NKI27_17800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NKI27_17815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NKI27_17820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NKI27_17825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NKI27_17830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NKI27_17835	COG1610	YqeY-like protein
NKI27_17940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NKI27_17945	COG0583	DNA-binding transcription factor activity
NKI27_17960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NKI27_17975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NKI27_17980	COG1561	YicC-like family, N-terminal region
NKI27_17985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NKI27_18010	COG1538	Outer membrane efflux protein
NKI27_18020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NKI27_18055	COG2771	luxR family
NKI27_18070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NKI27_18090	COG0826	peptidase U32
NKI27_18095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NKI27_18135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NKI27_18140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NKI27_18145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NKI27_18145	COG2813	Specifically methylates the guanine in position
NKI27_18155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NKI27_18160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NKI27_18170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NKI27_18175	COG0590	tRNA wobble adenosine to inosine editing
NKI27_18180	COG0606	chelatase, subunit chli
NKI27_18190	COG0347	Belongs to the P(II) protein family
NKI27_18195	COG0004	ammonium transporteR
NKI27_18200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NKI27_18205	COG1166	arginine decarboxylase activity
NKI27_18225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NKI27_18235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NKI27_18245	COG1960	acyl-CoA dehydrogenase activity
NKI27_18255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NKI27_18285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NKI27_18290	COG4597	amino acid ABC transporter
NKI27_18295	COG0765	amino acid transport
NKI27_18300	COG1126	abc transporter atp-binding protein
NKI27_18335	COG0517	IMP dehydrogenase activity
NKI27_18345	COG0596	Alpha beta hydrolase
NKI27_18355	COG3647	Membrane
NKI27_18365	COG1278	Cold shock
NKI27_18380	COG3123	guanosine phosphorylase activity
NKI27_18400	COG1278	Cold shock
NKI27_18410	COG1671	Belongs to the UPF0178 family
NKI27_18495	COG0033	Phosphoglucomutase
NKI27_18500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NKI27_18510	COG2205	protein histidine kinase activity
NKI27_18510	COG3437	response regulator, receiver
NKI27_18510	COG3850	Histidine kinase
NKI27_18510	COG4999	Histidine kinase
NKI27_18515	COG2205	protein histidine kinase activity
NKI27_18515	COG3437	response regulator, receiver
NKI27_18515	COG3850	Histidine kinase
NKI27_18515	COG4999	Histidine kinase
NKI27_18525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NKI27_18530	COG4681	YaeQ
NKI27_18555	COG0730	response to heat
NKI27_18560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NKI27_18560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NKI27_18565	COG0477	Major facilitator Superfamily
NKI27_18570	COG1942	4-Oxalocrotonate Tautomerase
NKI27_18590	COG1739	Uncharacterized protein family UPF0029
NKI27_18595	COG0741	lytic transglycosylase activity
NKI27_18605	COG5002	protein histidine kinase activity
NKI27_18615	COG2204	response regulator
NKI27_18635	COG2197	response regulator
NKI27_18640	COG5002	protein histidine kinase activity
NKI27_18640	COG5000	phosphorelay sensor kinase activity
NKI27_18650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NKI27_18655	COG0545	Peptidyl-prolyl cis-trans isomerase
NKI27_18680	COG3530	Putative quorum-sensing-regulated virulence factor
NKI27_18690	COG2832	Protein of unknown function (DUF454)
NKI27_18695	COG0617	tRNA 3'-terminal CCA addition
NKI27_18695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NKI27_18695	COG3620	sequence-specific DNA binding
NKI27_18720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NKI27_18725	COG2354	Protein conserved in bacteria
NKI27_18750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NKI27_18775	COG0579	oxidoreductase
NKI27_18810	COG0545	Peptidyl-prolyl cis-trans isomerase
NKI27_18835	COG0017	Asparaginyl-tRNA synthetase
NKI27_18845	COG0513	Belongs to the DEAD box helicase family
NKI27_18860	COG0318	PFAM AMP-dependent synthetase and ligase
NKI27_18885	COG2195	Cleaves the N-terminal amino acid of tripeptides
NKI27_18925	COG0602	queuosine metabolic process
NKI27_18930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NKI27_18950	COG2201	protein-glutamate methylesterase activity
NKI27_18960	COG0784	Response regulator, receiver
NKI27_18960	COG2205	protein histidine kinase activity
NKI27_18975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NKI27_18985	COG3920	Histidine kinase
NKI27_18990	COG0109	protoheme IX farnesyltransferase activity
NKI27_18995	COG1612	heme a metabolic process
NKI27_19020	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NKI27_19030	COG1565	acr, cog1565
NKI27_19030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NKI27_19035	COG0534	Mate efflux family protein
NKI27_19050	COG0339	signal peptide processing
NKI27_19055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NKI27_19070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NKI27_19075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NKI27_19085	COG0009	L-threonylcarbamoyladenylate synthase
NKI27_19090	COG0758	DNA mediated transformation
NKI27_19100	COG0242	peptide deformylase activity
NKI27_19105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NKI27_19115	COG0569	domain protein
NKI27_19120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NKI27_19140	COG0752	glycyl-tRNA synthetase alpha subunit
NKI27_19145	COG0751	glycine-tRNA ligase activity
NKI27_19150	COG1560	Kdo2-lipid A biosynthetic process
NKI27_19170	COG0557	exoribonuclease II activity
NKI27_19175	COG1278	Cold shock
NKI27_19180	COG0589	response to stress
NKI27_19185	COG0589	response to stress
NKI27_19190	COG0642	Histidine kinase
NKI27_19200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NKI27_19255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NKI27_19265	COG0594	ribonuclease P activity
NKI27_19270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane