locus-tag	class	description
Amet_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Amet_0002	COG0592	DNA-directed DNA polymerase activity
Amet_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Amet_0006	COG0187	DNA topoisomerase II activity
Amet_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Amet_0008	COG1366	Belongs to the anti-sigma-factor antagonist family
Amet_0015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amet_0016	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amet_0017	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Amet_0018	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Amet_0019	COG0157	Belongs to the NadC ModD family
Amet_0020	COG1827	regulation of RNA biosynthetic process
Amet_0022	COG1615	UPF0182 protein
Amet_0024	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Amet_0026	COG0590	tRNA wobble adenosine to inosine editing
Amet_0027	COG0425	Belongs to the sulfur carrier protein TusA family
Amet_0029	COG0668	transmembrane transport
Amet_0031	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amet_0032	COG0360	Binds together with S18 to 16S ribosomal RNA
Amet_0034	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Amet_0039	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amet_0040	COG1288	antiporter activity
Amet_0041	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amet_0043	COG0840	transmembrane signaling receptor activity
Amet_0046	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Amet_0047	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Amet_0051	COG0535	radical SAM domain protein
Amet_0052	COG0641	radical SAM
Amet_0053	COG2855	membrane
Amet_0056	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_0058	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Amet_0059	COG1648	precorrin-2 dehydrogenase activity
Amet_0059	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Amet_0060	COG0181	hydroxymethylbilane synthase activity
Amet_0062	COG0113	porphobilinogen synthase activity
Amet_0063	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Amet_0065	COG1797	cobyrinic acid a,c-diamide synthase activity
Amet_0070	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Amet_0074	COG2875	Belongs to the precorrin methyltransferase family
Amet_0081	COG1982	Orn Lys Arg decarboxylase major
Amet_0082	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Amet_0083	COG3870	Protein conserved in bacteria
Amet_0085	COG1774	PSP1 C-terminal conserved region
Amet_0086	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Amet_0087	COG1191	sigma factor activity
Amet_0090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Amet_0091	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Amet_0092	COG2002	toxin-antitoxin pair type II binding
Amet_0094	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Amet_0095	COG2715	membrane protein required for spore maturation
Amet_0096	COG0700	Nucleoside recognition
Amet_0097	COG3191	aminopeptidase activity
Amet_0098	COG4512	PFAM Accessory gene regulator B
Amet_0101	COG1136	(ABC) transporter
Amet_0101	COG0577	efflux transmembrane transporter activity
Amet_0102	COG3290	protein histidine kinase activity
Amet_0103	COG3279	Response regulator of the LytR AlgR family
Amet_0108	COG1595	DNA-templated transcription, initiation
Amet_0110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amet_0110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amet_0111	COG0084	hydrolase, TatD family'
Amet_0117	COG4372	Transposase
Amet_0130	COG2217	Heavy metal translocating P-type atpase
Amet_0132	COG1725	Transcriptional regulator
Amet_0133	COG1131	(ABC) transporter
Amet_0135	COG2340	Cysteine-rich secretory protein family
Amet_0136	COG3583	domain protein
Amet_0136	COG3584	3D domain protein
Amet_0138	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Amet_0140	COG0530	calcium, potassium:sodium antiporter activity
Amet_0146	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Amet_0147	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Amet_0148	COG2195	Cleaves the N-terminal amino acid of tripeptides
Amet_0149	COG1982	Orn Lys Arg decarboxylase major
Amet_0153	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Amet_0154	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amet_0155	COG2088	sporulation resulting in formation of a cellular spore
Amet_0156	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Amet_0158	COG0193	aminoacyl-tRNA hydrolase activity
Amet_0160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Amet_0161	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Amet_0162	COG2002	toxin-antitoxin pair type II binding
Amet_0164	COG3956	TIGRFAM MazG family protein
Amet_0165	COG0776	regulation of translation
Amet_0166	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Amet_0168	COG2385	sporulation resulting in formation of a cellular spore
Amet_0172	COG1098	S1 RNA binding domain
Amet_0177	COG0793	Belongs to the peptidase S41A family
Amet_0178	COG2373	Large extracellular alpha-helical protein
Amet_0189	COG1309	transcriptional regulator
Amet_0192	COG3206	protein involved in exopolysaccharide biosynthesis
Amet_0192	COG0489	protein tyrosine kinase activity
Amet_0198	COG4537	Required for transformation and DNA binding
Amet_0201	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Amet_0204	COG0604	alcohol dehydrogenase
Amet_0206	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Amet_0207	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Amet_0210	COG3307	-O-antigen
Amet_0214	COG0728	peptidoglycan biosynthetic process
Amet_0217	COG1316	TRANSCRIPTIONal
Amet_0218	COG5464	transposase or invertase
Amet_0220	COG0606	chelatase, subunit chli
Amet_0221	COG0758	DNA mediated transformation
Amet_0224	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Amet_0224	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Amet_0226	COG3395	kinase activity
Amet_0227	COG1454	alcohol dehydrogenase
Amet_0228	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Amet_0229	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amet_0247	COG1406	Chemotaxis phosphatase CheX
Amet_0249	COG0840	transmembrane signaling receptor activity
Amet_0250	COG4810	utilization protein
Amet_0255	COG4303	Ethanolamine ammonia lyase large subunit
Amet_0257	COG4816	utilization protein
Amet_0258	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_0259	COG1012	belongs to the aldehyde dehydrogenase family
Amet_0259	COG1454	alcohol dehydrogenase
Amet_0260	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_0262	COG4869	propanediol catabolic process
Amet_0263	COG4820	ethanolamine utilization protein (EutJ)
Amet_0266	COG4656	Part of a membrane complex involved in electron transport
Amet_0268	COG3192	ethanolamine utilization protein
Amet_0271	COG4716	Myosin-crossreactive antigen
Amet_0277	COG1086	Polysaccharide biosynthesis protein
Amet_0282	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amet_0283	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Amet_0287	COG0653	protein targeting
Amet_0288	COG0745	RESPONSE REGULATOR receiver
Amet_0289	COG3850	Histidine kinase
Amet_0289	COG5002	protein histidine kinase activity
Amet_0295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Amet_0297	COG1360	Flagellar Motor Protein
Amet_0302	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Amet_0306	COG0463	Glycosyl transferase, family 2
Amet_0307	COG2246	polysaccharide biosynthetic process
Amet_0314	COG1309	transcriptional regulator
Amet_0315	COG0733	neurotransmitter:sodium symporter activity
Amet_0317	COG1607	acyl-coa hydrolase
Amet_0318	COG3246	L-lysine catabolic process to acetate
Amet_0319	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Amet_0321	COG1494	fructose-1,6-bisphosphatase
Amet_0322	COG1494	fructose-1,6-bisphosphatase
Amet_0323	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Amet_0324	COG0254	rRNA binding
Amet_0325	COG1435	thymidine kinase activity
Amet_0330	COG2890	protein-(glutamine-N5) methyltransferase activity
Amet_0331	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Amet_0333	COG1716	ATPase activity
Amet_0335	COG0768	penicillin binding
Amet_0336	COG0009	L-threonylcarbamoyladenylate synthase
Amet_0338	COG0698	ribose 5-phosphate isomerase
Amet_0339	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Amet_0340	COG0590	tRNA wobble adenosine to inosine editing
Amet_0341	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amet_0342	COG0733	neurotransmitter:sodium symporter activity
Amet_0343	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Amet_0349	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Amet_0350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Amet_0351	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Amet_0352	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Amet_0353	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Amet_0354	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Amet_0358	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Amet_0359	COG2385	sporulation resulting in formation of a cellular spore
Amet_0363	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Amet_0364	COG1609	Transcriptional regulator
Amet_0365	COG1077	Cell shape determining protein MreB Mrl
Amet_0366	COG1136	(ABC) transporter
Amet_0368	COG0577	efflux transmembrane transporter activity
Amet_0368	COG1136	(ABC) transporter
Amet_0369	COG4786	Flagellar basal body rod
Amet_0372	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Amet_0375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Amet_0381	COG2186	Transcriptional regulator
Amet_0389	COG2842	Transposition protein
Amet_0398	COG1191	sigma factor activity
Amet_0408	COG3409	Peptidoglycan-binding domain 1 protein
Amet_0408	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_0443	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amet_0444	COG3949	Membrane
Amet_0445	COG0277	FAD linked oxidase domain protein
Amet_0452	COG0484	heat shock protein binding
Amet_0454	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amet_0454	COG0519	Catalyzes the synthesis of GMP from XMP
Amet_0455	COG1609	Transcriptional regulator
Amet_0456	COG1879	ABC-type sugar transport system periplasmic component
Amet_0457	COG1129	ABC transporter
Amet_0458	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amet_0460	COG0673	inositol 2-dehydrogenase activity
Amet_0464	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Amet_0467	COG0840	transmembrane signaling receptor activity
Amet_0472	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amet_0472	COG2080	2 iron, 2 sulfur cluster binding
Amet_0475	COG4948	Mandelate Racemase Muconate Lactonizing
Amet_0476	COG1619	proteins homologs of microcin C7 resistance protein MccF
Amet_0479	COG3976	FMN-binding domain protein
Amet_0479	COG1053	succinate dehydrogenase
Amet_0480	COG1691	(AIR) carboxylase
Amet_0481	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Amet_0482	COG1606	tRNA processing
Amet_0483	COG4187	Peptidase family M20/M25/M40
Amet_0484	COG0045	succinate-CoA ligase (ADP-forming) activity
Amet_0485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Amet_0489	COG2197	response regulator
Amet_0500	COG1414	Transcriptional regulator
Amet_0501	COG2610	gluconate transmembrane transporter activity
Amet_0502	COG0129	dihydroxy-acid dehydratase activity
Amet_0503	COG0179	Fumarylacetoacetate (FAA) hydrolase
Amet_0504	COG0436	Aminotransferase
Amet_0507	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Amet_0511	COG0753	catalase activity
Amet_0511	COG0693	protein deglycase activity
Amet_0514	COG0697	spore germination
Amet_0515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Amet_0516	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Amet_0517	COG3639	organic phosphonate transmembrane transporter activity
Amet_0519	COG2884	Cell division ATP-binding protein ftsE
Amet_0521	COG0326	Molecular chaperone. Has ATPase activity
Amet_0525	COG1122	ATPase activity
Amet_0531	COG0406	alpha-ribazole phosphatase activity
Amet_0532	COG0393	Putative heavy-metal-binding
Amet_0538	COG3875	lactate racemase activity
Amet_0539	COG3949	Membrane
Amet_0541	COG3409	Peptidoglycan-binding domain 1 protein
Amet_0541	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_0542	COG0737	Belongs to the 5'-nucleotidase family
Amet_0544	COG2207	Transcriptional regulator
Amet_0546	COG0745	RESPONSE REGULATOR receiver
Amet_0547	COG3850	Histidine kinase
Amet_0547	COG5002	protein histidine kinase activity
Amet_0550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_0552	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amet_0552	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amet_0553	COG1802	Transcriptional regulator
Amet_0554	COG1063	alcohol dehydrogenase
Amet_0555	COG0246	Mannitol dehydrogenase
Amet_0556	COG2721	sulfolactate sulfo-lyase activity
Amet_0557	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Amet_0558	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_0559	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amet_0560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amet_0561	COG0584	glycerophosphoryl diester phosphodiesterase
Amet_0563	COG1285	pathogenesis
Amet_0564	COG3875	lactate racemase activity
Amet_0565	COG4492	Belongs to the UPF0735 family
Amet_0566	COG0460	homoserine dehydrogenase
Amet_0567	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Amet_0568	COG0083	homoserine kinase activity
Amet_0569	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Amet_0570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Amet_0571	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Amet_0572	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Amet_0573	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amet_0574	COG0131	Imidazoleglycerol-phosphate dehydratase
Amet_0575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Amet_0576	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Amet_0577	COG0107	imidazoleglycerol-phosphate synthase activity
Amet_0578	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Amet_0578	COG0140	phosphoribosyl-ATP diphosphatase activity
Amet_0579	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Amet_0580	COG0733	neurotransmitter:sodium symporter activity
Amet_0582	COG0840	transmembrane signaling receptor activity
Amet_0582	COG3290	protein histidine kinase activity
Amet_0585	COG0708	Exodeoxyribonuclease III
Amet_0586	COG1609	Transcriptional regulator
Amet_0587	COG1129	ABC transporter
Amet_0590	COG1063	alcohol dehydrogenase
Amet_0591	COG1070	Carbohydrate kinase
Amet_0592	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Amet_0594	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Amet_0600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amet_0602	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Amet_0607	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amet_0608	COG1766	The M ring may be actively involved in energy transduction
Amet_0609	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_0612	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_0613	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_0613	COG1776	CheC inhibitor of MCP methylation
Amet_0614	COG2201	protein-glutamate methylesterase activity
Amet_0615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Amet_0617	COG0789	Transcriptional regulator
Amet_0617	COG4978	Transcriptional regulator
Amet_0618	COG3279	Response regulator of the LytR AlgR family
Amet_0644	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Amet_0646	COG0287	Prephenate dehydrogenase
Amet_0647	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Amet_0648	COG0077	Prephenate dehydratase
Amet_0648	COG1605	Chorismate mutase
Amet_0649	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Amet_0650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Amet_0651	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Amet_0652	COG0165	Argininosuccinate lyase
Amet_0653	COG0137	argininosuccinate synthase activity
Amet_0655	COG5002	protein histidine kinase activity
Amet_0656	COG0745	RESPONSE REGULATOR receiver
Amet_0660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amet_0661	COG1288	antiporter activity
Amet_0662	COG1533	DNA photolyase activity
Amet_0664	COG4656	Part of a membrane complex involved in electron transport
Amet_0665	COG5275	peptidyl-tyrosine sulfation
Amet_0665	COG0252	asparaginase activity
Amet_0667	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Amet_0668	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Amet_0669	COG0252	asparaginase activity
Amet_0669	COG5275	peptidyl-tyrosine sulfation
Amet_0670	COG0252	asparaginase activity
Amet_0670	COG5275	peptidyl-tyrosine sulfation
Amet_0673	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Amet_0674	COG0442	prolyl-tRNA aminoacylation
Amet_0675	COG0840	transmembrane signaling receptor activity
Amet_0677	COG0179	Fumarylacetoacetate (FAA) hydrolase
Amet_0678	COG2379	hydroxypyruvate reductase
Amet_0683	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amet_0685	COG2508	Transcriptional regulator
Amet_0687	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Amet_0689	COG1304	FMN binding
Amet_0690	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Amet_0692	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Amet_0694	COG1757	Na H antiporter
Amet_0697	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Amet_0698	COG0531	amino acid
Amet_0700	COG3290	protein histidine kinase activity
Amet_0700	COG3829	transcription factor binding
Amet_0702	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amet_0702	COG1522	sequence-specific DNA binding
Amet_0703	COG2313	pseudouridylate synthase activity
Amet_0704	COG5000	phosphorelay sensor kinase activity
Amet_0705	COG3906	Belongs to the UPF0473 family
Amet_0707	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Amet_0708	COG0745	RESPONSE REGULATOR receiver
Amet_0709	COG5002	protein histidine kinase activity
Amet_0722	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Amet_0727	COG4786	Flagellar basal body rod
Amet_0727	COG1256	bacterial-type flagellum assembly
Amet_0728	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Amet_0730	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Amet_0731	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Amet_0750	COG1592	Rubrerythrin
Amet_0750	COG1773	rubredoxin
Amet_0752	COG3437	response regulator, receiver
Amet_0752	COG2770	Histidine kinase
Amet_0759	COG3976	FMN-binding domain protein
Amet_0759	COG1053	succinate dehydrogenase
Amet_0759	COG0431	NADPH-dependent FMN reductase
Amet_0760	COG0778	Nitroreductase
Amet_0761	COG1307	EDD domain protein, DegV family
Amet_0764	COG0277	FAD linked oxidase domain protein
Amet_0765	COG2086	electron transfer activity
Amet_0766	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amet_0767	COG0786	glutamate:sodium symporter activity
Amet_0769	COG0456	acetyltransferase
Amet_0769	COG0454	-acetyltransferase
Amet_0771	COG1639	'signal transduction protein
Amet_0775	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Amet_0777	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Amet_0783	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Amet_0785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Amet_0786	COG1516	flagellar protein fliS
Amet_0788	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Amet_0790	COG0653	protein targeting
Amet_0791	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Amet_0795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Amet_0797	COG1368	sulfuric ester hydrolase activity
Amet_0798	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Amet_0799	COG2183	response to ionizing radiation
Amet_0800	COG2271	Major facilitator Superfamily
Amet_0802	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Amet_0803	COG0802	atpase or kinase
Amet_0804	COG1214	PFAM Peptidase M22, glycoprotease
Amet_0805	COG0456	acetyltransferase
Amet_0810	COG0488	(ABC) transporter
Amet_0813	COG2221	Nitrite and sulphite reductase 4Fe-4S
Amet_0817	COG1620	l-lactate permease
Amet_0818	COG2186	Transcriptional regulator
Amet_0819	COG2086	electron transfer activity
Amet_0820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amet_0821	COG0277	FAD linked oxidase domain protein
Amet_0822	COG0011	TIGRFAM Protein of
Amet_0823	COG1131	(ABC) transporter
Amet_0825	COG1349	DNA-binding transcription factor activity
Amet_0827	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Amet_0827	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Amet_0827	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Amet_0829	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amet_0832	COG1811	Na channel or pump
Amet_0833	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Amet_0834	COG0459	protein refolding
Amet_0835	COG0582	viral genome integration into host DNA
Amet_0847	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Amet_0848	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Amet_0849	COG0732	type I restriction modification DNA specificity domain
Amet_0869	COG0756	dUTP diphosphatase activity
Amet_0870	COG0697	spore germination
Amet_0886	COG1396	sequence-specific DNA binding
Amet_0888	COG2207	Transcriptional regulator
Amet_0889	COG0697	spore germination
Amet_0890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amet_0891	COG0561	phosphatase activity
Amet_0892	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amet_0894	COG3842	ATPase activity
Amet_0895	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Amet_0897	COG1175	transmembrane transport
Amet_0898	COG0395	ABC-type sugar transport system, permease component
Amet_0900	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Amet_0901	COG1028	Short-chain dehydrogenase reductase Sdr
Amet_0902	COG1609	Transcriptional regulator
Amet_0905	COG5577	PFAM Coat F domain
Amet_0909	COG0516	GMP reductase activity
Amet_0909	COG0517	IMP dehydrogenase activity
Amet_0910	COG0519	Catalyzes the synthesis of GMP from XMP
Amet_0910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amet_0913	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Amet_0914	COG1596	polysaccharide export
Amet_0914	COG1555	photosystem II stabilization
Amet_0916	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Amet_0917	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Amet_0918	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Amet_0919	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Amet_0920	COG0047	phosphoribosylformylglycinamidine synthase activity
Amet_0921	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Amet_0922	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Amet_0923	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Amet_0924	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Amet_0925	COG0138	bifunctional purine biosynthesis protein purh
Amet_0926	COG0151	Belongs to the GarS family
Amet_0930	COG1464	Belongs to the NlpA lipoprotein family
Amet_0931	COG2011	ABC-type metal ion transport system permease component
Amet_0932	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Amet_0934	COG4496	protein, YerC YecD
Amet_0935	COG0527	aspartate kinase activity
Amet_0940	COG0840	transmembrane signaling receptor activity
Amet_0941	COG0210	DNA helicase
Amet_0942	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amet_0945	COG1592	Rubrerythrin
Amet_0950	COG3069	C4-dicarboxylate transmembrane transporter activity
Amet_0953	COG2247	cell wall binding repeat
Amet_0953	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_0954	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Amet_0955	COG5401	PFAM Sporulation and spore germination
Amet_0958	COG0622	Phosphoesterase
Amet_0967	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amet_0967	COG2199	diguanylate cyclase activity
Amet_0969	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_0971	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amet_0974	COG0446	pyridine nucleotide-disulphide oxidoreductase
Amet_0976	COG1285	pathogenesis
Amet_0977	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
Amet_0979	COG0583	DNA-binding transcription factor activity
Amet_0984	COG0798	PFAM Bile acid sodium symporter
Amet_0989	COG0746	molybdenum cofactor guanylyltransferase activity
Amet_0990	COG0243	molybdopterin cofactor binding
Amet_0991	COG0437	4 iron, 4 sulfur cluster binding
Amet_0994	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Amet_0996	COG0303	'Molybdopterin
Amet_0998	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Amet_0999	COG0805	protein transport
Amet_1000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Amet_1001	COG1185	polyribonucleotide nucleotidyltransferase activity
Amet_1004	COG3973	AAA domain
Amet_1006	COG1185	polyribonucleotide nucleotidyltransferase activity
Amet_1007	COG0494	nUDIX hydrolase
Amet_1010	COG0659	secondary active sulfate transmembrane transporter activity
Amet_1012	COG5002	protein histidine kinase activity
Amet_1013	COG0784	Response regulator, receiver
Amet_1013	COG5002	protein histidine kinase activity
Amet_1013	COG2198	Histidine kinase
Amet_1016	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Amet_1017	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Amet_1020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amet_1020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amet_1021	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Amet_1029	COG1316	TRANSCRIPTIONal
Amet_1030	COG2208	phosphoserine phosphatase activity
Amet_1040	COG2909	trisaccharide binding
Amet_1056	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_1063	COG1164	Oligoendopeptidase f
Amet_1064	COG3153	acetyltransferase
Amet_1064	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amet_1066	COG0544	peptidyl-prolyl cis-trans isomerase activity
Amet_1067	COG0740	serine-type endopeptidase activity
Amet_1068	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Amet_1069	COG2059	Chromate
Amet_1070	COG2059	Chromate
Amet_1071	COG1067	ATP-dependent peptidase activity
Amet_1071	COG0470	DNA polymerase III
Amet_1072	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Amet_1073	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Amet_1074	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Amet_1075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Amet_1078	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Amet_1078	COG0512	Glutamine amidotransferase of anthranilate synthase
Amet_1079	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Amet_1080	COG0134	indole-3-glycerol-phosphate synthase activity
Amet_1081	COG0135	phosphoribosylanthranilate isomerase activity
Amet_1082	COG0133	tryptophan synthase activity
Amet_1083	COG0159	tryptophan synthase activity
Amet_1084	COG1773	rubredoxin
Amet_1085	COG2309	aminopeptidase activity
Amet_1088	COG2364	Membrane
Amet_1094	COG2217	Heavy metal translocating P-type atpase
Amet_1099	COG0745	RESPONSE REGULATOR receiver
Amet_1100	COG2205	protein histidine kinase activity
Amet_1104	COG0248	Ppx GppA phosphatase
Amet_1110	COG1846	Transcriptional regulator
Amet_1111	COG0534	Mate efflux family protein
Amet_1119	COG4166	transmembrane transport
Amet_1120	COG0444	Belongs to the ABC transporter superfamily
Amet_1121	COG4608	Belongs to the ABC transporter superfamily
Amet_1122	COG0534	Mate efflux family protein
Amet_1123	COG3608	succinylglutamate desuccinylase aspartoacylase
Amet_1132	COG0601	transmembrane transport
Amet_1134	COG0444	Belongs to the ABC transporter superfamily
Amet_1136	COG0534	Mate efflux family protein
Amet_1137	COG2972	Histidine kinase
Amet_1144	COG1320	monovalent cation:proton antiporter activity
Amet_1148	COG1006	Multisubunit Na H antiporter MnhC subunit
Amet_1150	COG2188	Transcriptional regulator
Amet_1151	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
Amet_1153	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Amet_1155	COG3627	carbon phosphorus lyase activity
Amet_1156	COG4107	phosphonate C-P lyase system protein PhnK
Amet_1157	COG3454	Phosphonate metabolism
Amet_1158	COG4778	phosphonate C-P lyase system protein PhnL
Amet_1160	COG3639	organic phosphonate transmembrane transporter activity
Amet_1161	COG3639	organic phosphonate transmembrane transporter activity
Amet_1162	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Amet_1165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amet_1165	COG2199	diguanylate cyclase activity
Amet_1167	COG3706	GGDEF domain
Amet_1168	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Amet_1171	COG1924	4 iron, 4 sulfur cluster binding
Amet_1173	COG1121	(ABC) transporter
Amet_1174	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amet_1177	COG1151	hydroxylamine reductase activity
Amet_1186	COG2340	Cysteine-rich secretory protein family
Amet_1187	COG0840	transmembrane signaling receptor activity
Amet_1189	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Amet_1191	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Amet_1192	COG1473	amidohydrolase
Amet_1193	COG1414	Transcriptional regulator
Amet_1194	COG0006	proline dipeptidase activity
Amet_1198	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amet_1199	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amet_1205	COG1285	pathogenesis
Amet_1206	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Amet_1212	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amet_1213	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amet_1213	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amet_1220	COG2996	Protein conserved in bacteria
Amet_1223	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amet_1224	COG1592	Rubrerythrin
Amet_1224	COG1773	rubredoxin
Amet_1230	COG0701	Predicted permease
Amet_1234	COG1477	protein flavinylation
Amet_1236	COG1376	ErfK ybiS ycfS ynhG family protein
Amet_1237	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Amet_1240	COG1126	abc transporter atp-binding protein
Amet_1243	COG1285	pathogenesis
Amet_1247	COG0352	thiamine-phosphate diphosphorylase activity
Amet_1248	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Amet_1249	COG0352	thiamine-phosphate diphosphorylase activity
Amet_1249	COG0351	phosphomethylpyrimidine kinase
Amet_1254	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Amet_1255	COG2208	phosphoserine phosphatase activity
Amet_1256	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amet_1256	COG2199	diguanylate cyclase activity
Amet_1257	COG3711	transcriptional antiterminator
Amet_1258	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Amet_1259	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Amet_1260	COG1414	Transcriptional regulator
Amet_1261	COG0800	Aldolase
Amet_1263	COG2186	Transcriptional regulator
Amet_1264	COG2188	Transcriptional regulator
Amet_1266	COG3181	Tripartite tricarboxylate transporter family receptor
Amet_1273	COG0398	Pfam SNARE associated Golgi protein
Amet_1274	COG3437	response regulator, receiver
Amet_1276	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amet_1278	COG5002	protein histidine kinase activity
Amet_1282	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Amet_1283	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Amet_1285	COG0697	spore germination
Amet_1288	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_1290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amet_1291	COG1904	glucuronate isomerase
Amet_1292	COG1312	Catalyzes the dehydration of D-mannonate
Amet_1293	COG0246	Mannitol dehydrogenase
Amet_1295	COG1116	anion transmembrane transporter activity
Amet_1296	COG1278	Cold shock
Amet_1298	COG0658	competence protein
Amet_1298	COG2333	competence protein COMEC
Amet_1301	COG1472	Belongs to the glycosyl hydrolase 3 family
Amet_1303	COG4565	transcriptional regulatory protein
Amet_1304	COG0281	malic enzyme
Amet_1305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amet_1317	COG0728	peptidoglycan biosynthetic process
Amet_1319	COG0473	3-isopropylmalate dehydrogenase activity
Amet_1320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Amet_1321	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amet_1323	COG1725	Transcriptional regulator
Amet_1324	COG1131	(ABC) transporter
Amet_1326	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Amet_1327	COG3639	organic phosphonate transmembrane transporter activity
Amet_1328	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Amet_1330	COG0243	molybdopterin cofactor binding
Amet_1331	COG0437	4 iron, 4 sulfur cluster binding
Amet_1332	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amet_1334	COG2081	HI0933 family
Amet_1335	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Amet_1337	COG2210	Belongs to the sulfur carrier protein TusA family
Amet_1339	COG1309	transcriptional regulator
Amet_1343	COG4536	flavin adenine dinucleotide binding
Amet_1345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amet_1347	COG0561	phosphatase activity
Amet_1348	COG1053	succinate dehydrogenase
Amet_1349	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amet_1354	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Amet_1356	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amet_1357	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amet_1360	COG3872	metal-dependent enzyme
Amet_1365	COG0772	Belongs to the SEDS family
Amet_1366	COG2239	Acts as a magnesium transporter
Amet_1367	COG3773	Cell wall hydrolase
Amet_1367	COG3409	Peptidoglycan-binding domain 1 protein
Amet_1368	COG2959	enzyme of heme biosynthesis
Amet_1375	COG0166	Belongs to the GPI family
Amet_1376	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Amet_1377	COG3275	phosphorelay sensor kinase activity
Amet_1378	COG3279	Response regulator of the LytR AlgR family
Amet_1380	COG1966	Carbon starvation protein
Amet_1382	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amet_1383	COG2244	polysaccharide biosynthetic process
Amet_1394	COG3976	FMN-binding domain protein
Amet_1394	COG1053	succinate dehydrogenase
Amet_1398	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Amet_1400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Amet_1402	COG0525	valine-tRNA ligase activity
Amet_1403	COG0285	dihydrofolate synthase activity
Amet_1405	COG4974	Belongs to the 'phage' integrase family
Amet_1410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_1416	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Amet_1421	COG0693	protein deglycase activity
Amet_1422	COG1357	PFAM Pentapeptide repeats (8 copies)
Amet_1423	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amet_1426	COG2720	vancomycin resistance protein
Amet_1431	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Amet_1435	COG0346	lactoylglutathione lyase activity
Amet_1436	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amet_1440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Amet_1441	COG4335	DNA alkylation repair
Amet_1446	COG1151	hydroxylamine reductase activity
Amet_1447	COG0589	response to stress
Amet_1449	COG0840	transmembrane signaling receptor activity
Amet_1451	COG0488	(ABC) transporter
Amet_1458	COG5002	protein histidine kinase activity
Amet_1459	COG1136	(ABC) transporter
Amet_1460	COG0577	efflux transmembrane transporter activity
Amet_1463	COG1342	Belongs to the UPF0251 family
Amet_1469	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amet_1474	COG4977	sequence-specific DNA binding
Amet_1479	COG1846	Transcriptional regulator
Amet_1480	COG0003	Pfam Anion-transporting ATPase
Amet_1486	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_1491	COG2311	Membrane
Amet_1500	COG3559	Exporter of polyketide antibiotics
Amet_1501	COG1131	(ABC) transporter
Amet_1502	COG1309	transcriptional regulator
Amet_1504	COG2207	Transcriptional regulator
Amet_1504	COG3708	Transcriptional regulator
Amet_1505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Amet_1506	COG0745	RESPONSE REGULATOR receiver
Amet_1507	COG5002	protein histidine kinase activity
Amet_1510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Amet_1511	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Amet_1514	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amet_1516	COG0456	acetyltransferase
Amet_1519	COG5002	protein histidine kinase activity
Amet_1525	COG0574	Belongs to the PEP-utilizing enzyme family
Amet_1525	COG3848	Pyruvate phosphate dikinase
Amet_1526	COG2814	Major facilitator Superfamily
Amet_1536	COG0488	(ABC) transporter
Amet_1540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Amet_1545	COG1132	(ABC) transporter
Amet_1547	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amet_1553	COG0488	(ABC) transporter
Amet_1554	COG0577	efflux transmembrane transporter activity
Amet_1555	COG1136	(ABC) transporter
Amet_1556	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Amet_1557	COG4585	Histidine kinase
Amet_1559	COG2197	response regulator
Amet_1560	COG2311	Membrane
Amet_1565	COG1695	Transcriptional regulator
Amet_1570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Amet_1573	COG3706	GGDEF domain
Amet_1573	COG0745	RESPONSE REGULATOR receiver
Amet_1575	COG0840	transmembrane signaling receptor activity
Amet_1579	COG0346	lactoylglutathione lyase activity
Amet_1580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Amet_1586	COG0390	transport system, permease component
Amet_1588	COG1695	Transcriptional regulator
Amet_1593	COG4974	Belongs to the 'phage' integrase family
Amet_1602	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_1612	COG3328	transposase activity
Amet_1613	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Amet_1615	COG1283	sodium-dependent phosphate transmembrane transporter activity
Amet_1616	COG0436	Aminotransferase
Amet_1617	COG0726	polysaccharide deacetylase
Amet_1620	COG1956	GAF domain-containing protein
Amet_1624	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Amet_1626	COG2226	methyltransferase
Amet_1627	COG1278	Cold shock
Amet_1628	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Amet_1630	COG4399	Belongs to the UPF0754 family
Amet_1634	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Amet_1635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Amet_1636	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Amet_1637	COG0569	domain protein
Amet_1638	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amet_1639	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Amet_1640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amet_1640	COG0072	phenylalanine-tRNA ligase activity
Amet_1641	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Amet_1642	COG0826	peptidase U32
Amet_1644	COG1121	(ABC) transporter
Amet_1645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amet_1646	COG0803	Belongs to the bacterial solute-binding protein 9 family
Amet_1649	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_1650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amet_1654	COG0398	Pfam SNARE associated Golgi protein
Amet_1657	COG1454	alcohol dehydrogenase
Amet_1661	COG2878	Part of a membrane complex involved in electron transport
Amet_1667	COG1518	maintenance of DNA repeat elements
Amet_1668	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Amet_1670	COG0039	L-malate dehydrogenase activity
Amet_1671	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Amet_1673	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amet_1674	COG0765	amino acid transport
Amet_1675	COG1126	abc transporter atp-binding protein
Amet_1676	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amet_1676	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amet_1676	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amet_1676	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amet_1678	COG0058	SHG alpha-glucan phosphorylase activity
Amet_1681	COG1595	DNA-templated transcription, initiation
Amet_1688	COG1136	(ABC) transporter
Amet_1689	COG0577	efflux transmembrane transporter activity
Amet_1691	COG0745	RESPONSE REGULATOR receiver
Amet_1692	COG2205	protein histidine kinase activity
Amet_1694	COG2878	Part of a membrane complex involved in electron transport
Amet_1695	COG1408	metallophosphoesterase
Amet_1697	COG0426	domain, Protein
Amet_1698	COG0456	acetyltransferase
Amet_1700	COG0604	alcohol dehydrogenase
Amet_1704	COG1058	Belongs to the CinA family
Amet_1704	COG1546	Belongs to the CinA family
Amet_1706	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amet_1707	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Amet_1709	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Amet_1711	COG0726	polysaccharide deacetylase
Amet_1712	COG1193	negative regulation of DNA recombination
Amet_1713	COG1683	Conserved Protein
Amet_1714	COG0018	arginyl-trna synthetase
Amet_1715	COG0840	transmembrane signaling receptor activity
Amet_1718	COG0534	Mate efflux family protein
Amet_1722	COG1032	radical SAM domain protein
Amet_1726	COG0280	phosphate acetyltransferase
Amet_1732	COG0737	Belongs to the 5'-nucleotidase family
Amet_1733	COG3842	ATPase activity
Amet_1734	COG1175	transmembrane transport
Amet_1735	COG0395	ABC-type sugar transport system, permease component
Amet_1736	COG1653	transport
Amet_1737	COG1185	polyribonucleotide nucleotidyltransferase activity
Amet_1746	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Amet_1757	COG1484	DNA-dependent DNA replication
Amet_1758	COG4584	PFAM Integrase catalytic
Amet_1758	COG2390	Transcriptional regulator
Amet_1760	COG2226	methyltransferase
Amet_1761	COG0346	lactoylglutathione lyase activity
Amet_1769	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Amet_1770	COG0745	RESPONSE REGULATOR receiver
Amet_1771	COG5002	protein histidine kinase activity
Amet_1780	COG4221	oxidoreductase activity
Amet_1782	COG1408	metallophosphoesterase
Amet_1783	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Amet_1798	COG1595	DNA-templated transcription, initiation
Amet_1802	COG1595	DNA-templated transcription, initiation
Amet_1828	COG0798	PFAM Bile acid sodium symporter
Amet_1833	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Amet_1838	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amet_1841	COG0640	Transcriptional regulator
Amet_1846	COG1131	(ABC) transporter
Amet_1851	COG1595	DNA-templated transcription, initiation
Amet_1861	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amet_1873	COG1846	Transcriptional regulator
Amet_1879	COG0444	Belongs to the ABC transporter superfamily
Amet_1880	COG4608	Belongs to the ABC transporter superfamily
Amet_1881	COG0747	negative chemotaxis
Amet_1883	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amet_1891	COG1595	DNA-templated transcription, initiation
Amet_1901	COG3620	sequence-specific DNA binding
Amet_1905	COG3173	Aminoglycoside phosphotransferase
Amet_1908	COG1309	transcriptional regulator
Amet_1913	COG1309	transcriptional regulator
Amet_1914	COG0574	Belongs to the PEP-utilizing enzyme family
Amet_1914	COG3848	Pyruvate phosphate dikinase
Amet_1915	COG0745	RESPONSE REGULATOR receiver
Amet_1927	COG2842	Transposition protein
Amet_1936	COG1191	sigma factor activity
Amet_1945	COG3409	Peptidoglycan-binding domain 1 protein
Amet_1945	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_1982	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_1986	COG1882	Formate acetyltransferase
Amet_1993	COG0745	RESPONSE REGULATOR receiver
Amet_2002	COG1131	(ABC) transporter
Amet_2005	COG0601	transmembrane transport
Amet_2007	COG0747	negative chemotaxis
Amet_2008	COG0444	Belongs to the ABC transporter superfamily
Amet_2009	COG4608	Belongs to the ABC transporter superfamily
Amet_2011	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amet_2013	COG0640	Transcriptional regulator
Amet_2016	COG1151	hydroxylamine reductase activity
Amet_2019	COG3404	Formiminotransferase-cyclodeaminase
Amet_2020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Amet_2023	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Amet_2036	COG0601	transmembrane transport
Amet_2037	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amet_2038	COG1136	(ABC) transporter
Amet_2038	COG0577	efflux transmembrane transporter activity
Amet_2042	COG0741	lytic transglycosylase activity
Amet_2042	COG1196	nuclear chromosome segregation
Amet_2042	COG0739	heme binding
Amet_2046	COG0601	transmembrane transport
Amet_2048	COG0444	Belongs to the ABC transporter superfamily
Amet_2049	COG4608	Belongs to the ABC transporter superfamily
Amet_2054	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Amet_2056	COG0534	Mate efflux family protein
Amet_2058	COG0741	lytic transglycosylase activity
Amet_2058	COG0739	heme binding
Amet_2058	COG1196	nuclear chromosome segregation
Amet_2059	COG0662	Cupin 2, conserved barrel domain protein
Amet_2060	COG3290	protein histidine kinase activity
Amet_2060	COG3829	transcription factor binding
Amet_2061	COG0747	negative chemotaxis
Amet_2062	COG0601	transmembrane transport
Amet_2064	COG0444	Belongs to the ABC transporter superfamily
Amet_2065	COG4608	Belongs to the ABC transporter superfamily
Amet_2067	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amet_2068	COG2362	D-Aminopeptidase
Amet_2069	COG0784	Response regulator, receiver
Amet_2069	COG2198	Histidine kinase
Amet_2069	COG2205	protein histidine kinase activity
Amet_2070	COG1309	transcriptional regulator
Amet_2072	COG1846	Transcriptional regulator
Amet_2075	COG0559	Belongs to the binding-protein-dependent transport system permease family
Amet_2079	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Amet_2080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amet_2086	COG5012	cobalamin binding
Amet_2093	COG5012	cobalamin binding
Amet_2094	COG2211	Major facilitator Superfamily
Amet_2097	COG5012	cobalamin binding
Amet_2098	COG2188	Transcriptional regulator
Amet_2104	COG3655	Transcriptional regulator
Amet_2109	COG3655	Transcriptional regulator
Amet_2119	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amet_2122	COG1404	Belongs to the peptidase S8 family
Amet_2144	COG0202	RNA polymerase activity
Amet_2149	COG1595	DNA-templated transcription, initiation
Amet_2155	COG0668	transmembrane transport
Amet_2156	COG1418	mRNA catabolic process
Amet_2159	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Amet_2161	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Amet_2162	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Amet_2163	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Amet_2164	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Amet_2170	COG2268	Band 7 protein
Amet_2171	COG0124	histidyl-tRNA synthetase
Amet_2172	COG3706	GGDEF domain
Amet_2173	COG2078	PFAM AMMECR1 domain protein
Amet_2173	COG3885	ferrous iron binding
Amet_2175	COG1132	(ABC) transporter
Amet_2179	COG0706	membrane insertase activity
Amet_2180	COG0628	permease
Amet_2181	COG2357	RelA SpoT domain protein
Amet_2182	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amet_2183	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Amet_2195	COG1518	maintenance of DNA repeat elements
Amet_2196	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Amet_2202	COG0210	DNA helicase
Amet_2206	COG0301	tRNA thio-modification
Amet_2207	COG0315	cyclic pyranopterin monophosphate synthase activity
Amet_2208	COG0521	Mo-molybdopterin cofactor biosynthetic process
Amet_2209	COG1950	PFAM Membrane protein of
Amet_2210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Amet_2220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amet_2225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Amet_2229	COG1739	Uncharacterized protein family UPF0029
Amet_2232	COG0730	response to heat
Amet_2233	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_2234	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Amet_2235	COG0217	transcriptional regulatory protein
Amet_2237	COG4974	Belongs to the 'phage' integrase family
Amet_2257	COG1476	TRANSCRIPTIONal
Amet_2258	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amet_2261	COG0456	acetyltransferase
Amet_2279	COG0784	Response regulator, receiver
Amet_2279	COG2205	protein histidine kinase activity
Amet_2280	COG4656	Part of a membrane complex involved in electron transport
Amet_2281	COG4658	electron transport chain
Amet_2282	COG4659	FMN binding
Amet_2283	COG4660	Part of a membrane complex involved in electron transport
Amet_2284	COG4657	Part of a membrane complex involved in electron transport
Amet_2285	COG2878	Part of a membrane complex involved in electron transport
Amet_2285	COG1245	4Fe-4S binding domain
Amet_2288	COG0424	maF-like protein
Amet_2289	COG2003	Belongs to the UPF0758 family
Amet_2290	COG1077	Cell shape determining protein MreB Mrl
Amet_2293	COG0768	penicillin binding
Amet_2294	COG0850	regulation of cytokinetic process
Amet_2295	COG2894	cell division
Amet_2296	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Amet_2297	COG1803	Methylglyoxal synthase
Amet_2299	COG1994	Peptidase M50
Amet_2302	COG1530	ribonuclease E activity
Amet_2303	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Amet_2305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Amet_2307	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Amet_2309	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Amet_2310	COG1713	HD superfamily hydrolase involved in NAD metabolism
Amet_2311	COG1316	TRANSCRIPTIONal
Amet_2312	COG0530	calcium, potassium:sodium antiporter activity
Amet_2313	COG0799	negative regulation of ribosome biogenesis
Amet_2314	COG0495	leucyl-tRNA aminoacylation
Amet_2316	COG0251	oxidation-reduction process
Amet_2317	COG1760	l-serine dehydratase
Amet_2318	COG1760	l-serine dehydratase
Amet_2319	COG1686	Belongs to the peptidase S11 family
Amet_2321	COG0709	Synthesizes selenophosphate from selenide and ATP
Amet_2322	COG1115	amino acid carrier protein
Amet_2323	COG1921	L-seryl-tRNASec selenium transferase activity
Amet_2325	COG0745	RESPONSE REGULATOR receiver
Amet_2326	COG5002	protein histidine kinase activity
Amet_2334	COG2155	Conserved Protein
Amet_2337	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Amet_2338	COG0632	four-way junction helicase activity
Amet_2339	COG2255	four-way junction helicase activity
Amet_2340	COG2385	sporulation resulting in formation of a cellular spore
Amet_2341	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Amet_2343	COG1862	Preprotein translocase
Amet_2348	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amet_2349	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amet_2351	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Amet_2351	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Amet_2352	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amet_2353	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Amet_2354	COG1490	D-aminoacyl-tRNA deacylase activity
Amet_2355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amet_2357	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Amet_2358	COG0124	histidyl-tRNA synthetase
Amet_2359	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Amet_2361	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Amet_2365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amet_2366	COG3829	transcription factor binding
Amet_2367	COG3804	dihydrodipicolinate reductase
Amet_2369	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_2371	COG5012	cobalamin binding
Amet_2373	COG3457	Alanine racemase
Amet_2382	COG0464	growth
Amet_2406	COG3773	Cell wall hydrolase
Amet_2406	COG3409	Peptidoglycan-binding domain 1 protein
Amet_2408	COG5484	DNA packaging
Amet_2430	COG3299	homolog of phage Mu protein gp47
Amet_2446	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Amet_2450	COG2340	Cysteine-rich secretory protein family
Amet_2451	COG1091	dTDP-4-dehydrorhamnose reductase activity
Amet_2452	COG1959	2 iron, 2 sulfur cluster binding
Amet_2454	COG0822	iron-sulfur transferase activity
Amet_2457	COG0628	permease
Amet_2458	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Amet_2459	COG4472	Bacterial protein of unknown function (DUF965)
Amet_2461	COG0667	Aldo Keto reductase
Amet_2462	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Amet_2463	COG3906	Belongs to the UPF0473 family
Amet_2465	COG1489	DNA binding
Amet_2466	COG0735	belongs to the Fur family
Amet_2467	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Amet_2472	COG0572	uridine kinase
Amet_2473	COG0768	penicillin binding
Amet_2480	COG1191	sigma factor activity
Amet_2482	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Amet_2483	COG4970	Tfp pilus assembly protein FimT
Amet_2488	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Amet_2489	COG0006	proline dipeptidase activity
Amet_2490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Amet_2492	COG3854	ATPases associated with a variety of cellular activities
Amet_2500	COG1302	Protein conserved in bacteria
Amet_2501	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Amet_2502	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Amet_2503	COG1570	exodeoxyribonuclease VII activity
Amet_2504	COG1722	exodeoxyribonuclease VII activity
Amet_2505	COG0142	geranyltranstransferase activity
Amet_2506	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Amet_2508	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Amet_2509	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Amet_2510	COG1438	arginine binding
Amet_2511	COG0497	DNA recombination
Amet_2512	COG0750	zinc metalloprotease
Amet_2515	COG2137	regulation of response to DNA damage stimulus
Amet_2518	COG0463	Glycosyl transferase, family 2
Amet_2521	COG0494	nUDIX hydrolase
Amet_2522	COG1300	Membrane
Amet_2523	COG4974	Belongs to the 'phage' integrase family
Amet_2524	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Amet_2525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Amet_2526	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Amet_2528	COG1686	Belongs to the peptidase S11 family
Amet_2529	COG0617	tRNA 3'-terminal CCA addition
Amet_2530	COG1994	Peptidase M50
Amet_2531	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Amet_2532	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Amet_2533	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Amet_2534	COG4974	Belongs to the 'phage' integrase family
Amet_2535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Amet_2537	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Amet_2539	COG1160	GTP binding
Amet_2540	COG0464	growth
Amet_2541	COG1923	regulation of RNA biosynthetic process
Amet_2542	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Amet_2543	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Amet_2544	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Amet_2545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amet_2559	COG3299	homolog of phage Mu protein gp47
Amet_2580	COG5484	DNA packaging
Amet_2585	COG0629	single-stranded DNA binding
Amet_2613	COG1396	sequence-specific DNA binding
Amet_2616	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_2617	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amet_2618	COG0436	Aminotransferase
Amet_2623	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Amet_2624	COG0539	negative regulation of cytoplasmic translation
Amet_2625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Amet_2626	COG0204	Acyl-transferase
Amet_2627	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Amet_2629	COG2081	HI0933 family
Amet_2631	COG1737	Transcriptional regulator
Amet_2633	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amet_2634	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amet_2634	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amet_2636	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Amet_2640	COG1187	pseudouridine synthase activity
Amet_2641	COG0445	tRNA wobble uridine modification
Amet_2643	COG1686	Belongs to the peptidase S11 family
Amet_2645	COG3874	Sporulation protein YtfJ
Amet_2648	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Amet_2649	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Amet_2655	COG0613	PHP domain protein
Amet_2656	COG2359	stage V sporulation protein S
Amet_2657	COG1418	mRNA catabolic process
Amet_2659	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Amet_2660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amet_2661	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Amet_2662	COG1674	ftsk spoiiie
Amet_2663	COG0740	serine-type endopeptidase activity
Amet_2665	COG0612	Peptidase, M16
Amet_2666	COG0726	polysaccharide deacetylase
Amet_2667	COG1185	polyribonucleotide nucleotidyltransferase activity
Amet_2668	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Amet_2669	COG0196	riboflavin kinase activity
Amet_2670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Amet_2671	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Amet_2672	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Amet_2673	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Amet_2676	COG0195	Participates in both transcription termination and antitermination
Amet_2677	COG0779	Required for maturation of 30S ribosomal subunits
Amet_2680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Amet_2681	COG0750	zinc metalloprotease
Amet_2682	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Amet_2683	COG4589	Belongs to the CDS family
Amet_2686	COG0233	cytoplasmic translational termination
Amet_2687	COG0528	UMP kinase activity
Amet_2688	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Amet_2689	COG0052	Belongs to the universal ribosomal protein uS2 family
Amet_2694	COG1191	sigma factor activity
Amet_2695	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Amet_2696	COG1776	CheC inhibitor of MCP methylation
Amet_2698	COG2198	Histidine kinase
Amet_2698	COG0643	Histidine kinase
Amet_2699	COG2201	protein-glutamate methylesterase activity
Amet_2701	COG0455	bacterial-type flagellum organization
Amet_2702	COG1419	protein localization to endoplasmic reticulum
Amet_2703	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Amet_2704	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Amet_2705	COG1684	flagellar biosynthetic protein fliR
Amet_2706	COG1987	bacterial-type flagellum assembly
Amet_2707	COG1338	Plays a role in the flagellum-specific transport system
Amet_2709	COG2201	protein-glutamate methylesterase activity
Amet_2710	COG1776	CheC inhibitor of MCP methylation
Amet_2710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_2711	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_2718	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Amet_2722	COG1157	protein secretion by the type III secretion system
Amet_2724	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amet_2725	COG1766	The M ring may be actively involved in energy transduction
Amet_2726	COG1677	Flagellar hook-basal body complex protein FliE
Amet_2727	COG1558	bacterial-type flagellum-dependent cell motility
Amet_2728	COG1815	bacterial-type flagellum-dependent cell motility
Amet_2732	COG0835	chemotaxis
Amet_2732	COG0784	Response regulator, receiver
Amet_2735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Amet_2736	COG0758	DNA mediated transformation
Amet_2739	COG0792	nuclease activity
Amet_2740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Amet_2741	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Amet_2742	COG0335	large ribosomal subunit rRNA binding
Amet_2743	COG0336	Belongs to the RNA methyltransferase TrmD family
Amet_2744	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Amet_2745	COG1837	Belongs to the UPF0109 family
Amet_2746	COG0228	four-way junction DNA binding
Amet_2747	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Amet_2749	COG0552	protein localization to endoplasmic reticulum
Amet_2750	COG1196	nuclear chromosome segregation
Amet_2752	COG0571	ribonuclease III activity
Amet_2753	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Amet_2754	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amet_2755	COG1028	Short-chain dehydrogenase reductase Sdr
Amet_2756	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Amet_2758	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amet_2759	COG0416	fatty acid biosynthetic process
Amet_2760	COG2030	dehydratase
Amet_2761	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Amet_2763	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Amet_2764	COG1323	Belongs to the UPF0348 family
Amet_2765	COG3314	Sporulation integral membrane protein YlbJ
Amet_2767	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Amet_2768	COG0742	ribosomal rna small subunit methyltransferase
Amet_2770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Amet_2771	COG1461	Dihydroxyacetone kinase
Amet_2772	COG1302	Protein conserved in bacteria
Amet_2773	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Amet_2776	COG1564	THIamine pyrophosphokinase
Amet_2777	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Amet_2778	COG1162	GTPase activity
Amet_2779	COG0515	serine threonine protein kinase
Amet_2779	COG2815	serine threonine protein kinase
Amet_2780	COG0631	protein serine/threonine phosphatase activity
Amet_2781	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Amet_2782	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Amet_2782	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Amet_2783	COG2738	Putative neutral zinc metallopeptidase
Amet_2785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Amet_2786	COG0242	peptide deformylase activity
Amet_2787	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Amet_2788	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Amet_2789	COG1758	RNA polymerase activity
Amet_2790	COG0194	GDP metabolic process
Amet_2791	COG2052	Domain of unknown function (DUF370)
Amet_2792	COG1561	YicC-like family, N-terminal region
Amet_2793	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Amet_2795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Amet_2796	COG0564	pseudouridine synthase activity
Amet_2797	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Amet_2798	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Amet_2801	COG2302	S4 RNA-binding domain
Amet_2803	COG1799	cell septum assembly
Amet_2804	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Amet_2808	COG4175	Glycine betaine
Amet_2808	COG0517	IMP dehydrogenase activity
Amet_2809	COG4176	ABC-type proline glycine betaine transport system permease component
Amet_2812	COG4214	carbohydrate transport
Amet_2814	COG4213	ABC transporter substrate-binding protein
Amet_2815	COG4213	ABC transporter substrate-binding protein
Amet_2816	COG4753	response regulator
Amet_2816	COG2207	Transcriptional regulator
Amet_2817	COG2972	Histidine kinase
Amet_2820	COG0584	glycerophosphoryl diester phosphodiesterase
Amet_2821	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Amet_2822	COG0542	response to heat
Amet_2824	COG1704	LemA family
Amet_2825	COG1388	LysM domain
Amet_2825	COG0791	NLP P60 protein
Amet_2855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Amet_2856	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Amet_2857	COG1160	GTP binding
Amet_2865	COG5002	protein histidine kinase activity
Amet_2866	COG0745	RESPONSE REGULATOR receiver
Amet_2868	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Amet_2869	COG1873	PFAM PRC-barrel domain
Amet_2870	COG1191	sigma factor activity
Amet_2871	COG1191	sigma factor activity
Amet_2873	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Amet_2878	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Amet_2879	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Amet_2880	COG0772	Belongs to the SEDS family
Amet_2881	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Amet_2882	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amet_2883	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Amet_2884	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Amet_2885	COG0768	penicillin binding
Amet_2887	COG0275	rRNA processing
Amet_2888	COG2001	Belongs to the MraZ family
Amet_2891	COG0612	Peptidase, M16
Amet_2892	COG0612	Peptidase, M16
Amet_2896	COG0012	GTP binding
Amet_2897	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Amet_2898	COG4869	propanediol catabolic process
Amet_2904	COG2096	Adenosyltransferase
Amet_2905	COG4608	Belongs to the ABC transporter superfamily
Amet_2906	COG0444	Belongs to the ABC transporter superfamily
Amet_2909	COG0747	negative chemotaxis
Amet_2911	COG4608	Belongs to the ABC transporter superfamily
Amet_2912	COG0444	Belongs to the ABC transporter superfamily
Amet_2914	COG0601	transmembrane transport
Amet_2915	COG0747	negative chemotaxis
Amet_2918	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Amet_2919	COG1333	cytochrome c biogenesis protein
Amet_2927	COG1595	DNA-templated transcription, initiation
Amet_2931	COG0789	Transcriptional regulator
Amet_2932	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Amet_2933	COG1051	belongs to the nudix hydrolase family
Amet_2934	COG0840	transmembrane signaling receptor activity
Amet_2935	COG0793	Belongs to the peptidase S41A family
Amet_2940	COG0546	phosphoglycolate phosphatase activity
Amet_2941	COG1473	amidohydrolase
Amet_2943	COG0840	transmembrane signaling receptor activity
Amet_2945	COG0058	SHG alpha-glucan phosphorylase activity
Amet_2946	COG0297	glycogen (starch) synthase activity
Amet_2947	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Amet_2948	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Amet_2949	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Amet_2952	COG0513	Belongs to the DEAD box helicase family
Amet_2953	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amet_2954	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amet_2956	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Amet_2959	COG2084	Dehydrogenase
Amet_2960	COG0840	transmembrane signaling receptor activity
Amet_2961	COG0679	Auxin Efflux Carrier
Amet_2962	COG0066	3-isopropylmalate dehydratase activity
Amet_2965	COG0281	malic enzyme
Amet_2967	COG3290	protein histidine kinase activity
Amet_2968	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Amet_2969	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Amet_2973	COG1984	allophanate hydrolase subunit 2
Amet_2974	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Amet_2975	COG4336	lyase activity
Amet_2976	COG1914	H( )-stimulated, divalent metal cation uptake system
Amet_2977	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Amet_2978	COG2204	response regulator
Amet_2979	COG3852	Histidine kinase
Amet_2980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Amet_2990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Amet_2991	COG2384	SAM-dependent methyltransferase
Amet_2993	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Amet_2994	COG0358	DNA primase activity
Amet_2995	COG1671	Belongs to the UPF0178 family
Amet_2996	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Amet_2998	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Amet_2999	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amet_3000	COG3976	FMN-binding domain protein
Amet_3000	COG0431	NADPH-dependent FMN reductase
Amet_3000	COG1053	succinate dehydrogenase
Amet_3001	COG0745	RESPONSE REGULATOR receiver
Amet_3002	COG5002	protein histidine kinase activity
Amet_3008	COG1309	transcriptional regulator
Amet_3009	COG0431	NADPH-dependent FMN reductase
Amet_3009	COG1053	succinate dehydrogenase
Amet_3009	COG3976	FMN-binding domain protein
Amet_3013	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Amet_3014	COG0716	FMN binding
Amet_3015	COG1937	Protein conserved in bacteria
Amet_3016	COG0534	Mate efflux family protein
Amet_3018	COG1695	Transcriptional regulator
Amet_3019	COG0574	Belongs to the PEP-utilizing enzyme family
Amet_3019	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Amet_3020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Amet_3021	COG0517	IMP dehydrogenase activity
Amet_3022	COG0423	glycine-tRNA ligase activity
Amet_3023	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Amet_3024	COG1381	Involved in DNA repair and RecF pathway recombination
Amet_3026	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Amet_3027	COG0295	cytidine deaminase activity
Amet_3028	COG1470	cell adhesion involved in biofilm formation
Amet_3030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Amet_3031	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Amet_3032	COG1480	7TM receptor with intracellular HD hydrolase
Amet_3033	COG1702	phosphate starvation-inducible protein PhoH
Amet_3037	COG4864	UPF0365 protein
Amet_3038	COG1030	water channel activity
Amet_3042	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Amet_3043	COG0537	adenosine 5'-monophosphoramidase activity
Amet_3044	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amet_3045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Amet_3046	COG2264	protein methyltransferase activity
Amet_3048	COG0443	Heat shock 70 kDa protein
Amet_3049	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Amet_3050	COG1420	regulation of RNA biosynthetic process
Amet_3051	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Amet_3052	COG0481	GTPase activity
Amet_3055	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Amet_3056	COG0268	Binds directly to 16S ribosomal RNA
Amet_3058	COG2333	competence protein COMEC
Amet_3058	COG0658	competence protein
Amet_3060	COG1234	tRNA 3'-trailer cleavage
Amet_3062	COG0658	competence protein
Amet_3062	COG2333	competence protein COMEC
Amet_3069	COG0842	Transport permease protein
Amet_3070	COG1131	(ABC) transporter
Amet_3071	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Amet_3072	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Amet_3073	COG0513	Belongs to the DEAD box helicase family
Amet_3075	COG0697	spore germination
Amet_3079	COG1136	(ABC) transporter
Amet_3081	COG1285	pathogenesis
Amet_3086	COG5002	protein histidine kinase activity
Amet_3087	COG0745	RESPONSE REGULATOR receiver
Amet_3089	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amet_3090	COG2086	electron transfer activity
Amet_3091	COG1960	acyl-CoA dehydrogenase activity
Amet_3092	COG2030	dehydratase
Amet_3103	COG0330	HflC and HflK could
Amet_3107	COG0187	DNA topoisomerase II activity
Amet_3113	COG1376	ErfK ybiS ycfS ynhG family protein
Amet_3114	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Amet_3115	COG0584	glycerophosphoryl diester phosphodiesterase
Amet_3116	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amet_3117	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Amet_3122	COG0747	negative chemotaxis
Amet_3124	COG0237	dephospho-CoA kinase activity
Amet_3125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amet_3125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amet_3128	COG1988	membrane-bound metal-dependent
Amet_3137	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Amet_3138	COG0583	DNA-binding transcription factor activity
Amet_3140	COG1362	aminopeptidase activity
Amet_3141	COG2197	response regulator
Amet_3145	COG4224	UPF0291 protein
Amet_3148	COG1228	amidohydrolase
Amet_3149	COG2986	histidine ammonia-lyase
Amet_3151	COG1846	Transcriptional regulator
Amet_3152	COG0739	heme binding
Amet_3154	COG1597	lipid kinase activity
Amet_3155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amet_3159	COG1132	(ABC) transporter
Amet_3160	COG1132	(ABC) transporter
Amet_3161	COG2235	arginine
Amet_3162	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Amet_3164	COG5001	Diguanylate cyclase
Amet_3164	COG1716	ATPase activity
Amet_3166	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Amet_3166	COG1796	DNA polymerase
Amet_3168	COG0303	'Molybdopterin
Amet_3169	COG0303	'Molybdopterin
Amet_3170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amet_3173	COG0564	pseudouridine synthase activity
Amet_3174	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Amet_3175	COG1301	dicarboxylic acid transport
Amet_3176	COG2201	protein-glutamate methylesterase activity
Amet_3182	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Amet_3187	COG4659	FMN binding
Amet_3188	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Amet_3193	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amet_3195	COG2171	N-acyltransferase activity
Amet_3196	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Amet_3197	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amet_3198	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Amet_3199	COG3773	Cell wall hydrolase
Amet_3200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amet_3202	COG0697	spore germination
Amet_3205	COG0095	Lipoate-protein ligase
Amet_3208	COG5002	protein histidine kinase activity
Amet_3209	COG0745	RESPONSE REGULATOR receiver
Amet_3211	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Amet_3212	COG0697	spore germination
Amet_3213	COG2851	Citrate transporter
Amet_3214	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Amet_3215	COG0583	DNA-binding transcription factor activity
Amet_3216	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Amet_3217	COG0511	ligase activity, forming carbon-carbon bonds
Amet_3219	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amet_3225	COG3052	prosthetic group binding
Amet_3227	COG0745	RESPONSE REGULATOR receiver
Amet_3228	COG4191	Histidine kinase
Amet_3229	COG0281	malic enzyme
Amet_3232	COG3850	Histidine kinase
Amet_3240	COG1268	BioY protein
Amet_3241	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Amet_3242	COG0840	transmembrane signaling receptor activity
Amet_3246	COG2239	Acts as a magnesium transporter
Amet_3249	COG5001	Diguanylate cyclase
Amet_3255	COG2204	response regulator
Amet_3256	COG3852	Histidine kinase
Amet_3258	COG2205	protein histidine kinase activity
Amet_3262	COG0791	NLP P60 protein
Amet_3262	COG1388	LysM domain
Amet_3271	COG2217	Heavy metal translocating P-type atpase
Amet_3272	COG2217	Heavy metal translocating P-type atpase
Amet_3279	COG2226	methyltransferase
Amet_3280	COG1032	radical SAM domain protein
Amet_3282	COG3546	catalase activity
Amet_3286	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Amet_3290	COG2897	thiosulfate sulfurtransferase activity
Amet_3291	COG2897	thiosulfate sulfurtransferase activity
Amet_3295	COG4134	Bacterial extracellular solute-binding protein
Amet_3297	COG0398	Pfam SNARE associated Golgi protein
Amet_3300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Amet_3305	COG0569	domain protein
Amet_3307	COG0745	RESPONSE REGULATOR receiver
Amet_3308	COG2205	protein histidine kinase activity
Amet_3310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Amet_3313	COG2056	Na+-H+ antiporter family
Amet_3314	COG1983	PspC domain protein
Amet_3316	COG5578	integral membrane protein
Amet_3317	COG3507	Belongs to the glycosyl hydrolase 43 family
Amet_3318	COG0395	ABC-type sugar transport system, permease component
Amet_3322	COG2972	Histidine kinase
Amet_3323	COG3842	ATPase activity
Amet_3324	COG3835	regulator
Amet_3325	COG1876	peptidase activity
Amet_3326	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amet_3328	COG0444	Belongs to the ABC transporter superfamily
Amet_3330	COG0601	transmembrane transport
Amet_3333	COG2878	Part of a membrane complex involved in electron transport
Amet_3334	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Amet_3335	COG0037	tRNA processing
Amet_3336	COG0488	(ABC) transporter
Amet_3338	COG0006	proline dipeptidase activity
Amet_3344	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amet_3355	COG1598	PFAM Uncharacterised protein family UPF0150
Amet_3360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_3363	COG0517	IMP dehydrogenase activity
Amet_3366	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amet_3371	COG0488	(ABC) transporter
Amet_3372	COG0488	(ABC) transporter
Amet_3373	COG0646	methionine synthase
Amet_3373	COG1410	methionine synthase
Amet_3375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Amet_3377	COG2340	Cysteine-rich secretory protein family
Amet_3378	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Amet_3379	COG0505	Belongs to the CarA family
Amet_3380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amet_3381	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Amet_3382	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Amet_3383	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Amet_3384	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Amet_3387	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Amet_3388	COG0154	amidase activity
Amet_3389	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Amet_3390	COG0017	Asparaginyl-tRNA synthetase
Amet_3391	COG0347	Belongs to the P(II) protein family
Amet_3392	COG0004	ammonium transporteR
Amet_3393	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Amet_3397	COG0067	glutamate synthase
Amet_3397	COG0069	glutamate synthase activity
Amet_3397	COG0070	glutamate synthase
Amet_3398	COG3830	Belongs to the UPF0237 family
Amet_3399	COG2848	UPF0210 protein
Amet_3400	COG0028	Belongs to the TPP enzyme family
Amet_3402	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Amet_3403	COG0440	acetolactate synthase activity
Amet_3404	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Amet_3406	COG0457	Tetratricopeptide repeat
Amet_3406	COG0463	Glycosyl transferase, family 2
Amet_3407	COG0527	aspartate kinase activity
Amet_3409	COG3051	citrate lyase alpha subunit
Amet_3411	COG3052	prosthetic group binding
Amet_3412	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Amet_3412	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Amet_3418	COG0028	Belongs to the TPP enzyme family
Amet_3419	COG0440	acetolactate synthase activity
Amet_3420	COG4868	Belongs to the UPF0371 family
Amet_3426	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Amet_3427	COG1686	Belongs to the peptidase S11 family
Amet_3436	COG0457	Tetratricopeptide repeat
Amet_3436	COG0463	Glycosyl transferase, family 2
Amet_3441	COG0438	transferase activity, transferring glycosyl groups
Amet_3442	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amet_3443	COG1388	LysM domain
Amet_3443	COG4641	Protein conserved in bacteria
Amet_3446	COG0189	ligase activity
Amet_3450	COG0463	Glycosyl transferase, family 2
Amet_3452	COG0438	transferase activity, transferring glycosyl groups
Amet_3454	COG1307	EDD domain protein, DegV family
Amet_3455	COG0473	3-isopropylmalate dehydrogenase activity
Amet_3456	COG0066	3-isopropylmalate dehydratase activity
Amet_3457	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Amet_3460	COG3976	FMN-binding domain protein
Amet_3460	COG1053	succinate dehydrogenase
Amet_3460	COG0431	NADPH-dependent FMN reductase
Amet_3462	COG1666	GTP binding
Amet_3464	COG4807	Protein conserved in bacteria
Amet_3466	COG0783	Belongs to the Dps family
Amet_3467	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Amet_3468	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Amet_3469	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Amet_3470	COG0363	glucosamine-6-phosphate deaminase activity
Amet_3479	COG2165	general secretion pathway protein
Amet_3484	COG1032	radical SAM domain protein
Amet_3485	COG1032	radical SAM domain protein
Amet_3486	COG2226	methyltransferase
Amet_3491	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Amet_3496	COG0529	Catalyzes the synthesis of activated sulfate
Amet_3497	COG0471	metal ion transport
Amet_3499	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amet_3501	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Amet_3503	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Amet_3514	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Amet_3515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amet_3517	COG1433	Dinitrogenase iron-molybdenum cofactor
Amet_3517	COG0535	radical SAM domain protein
Amet_3522	COG0347	Belongs to the P(II) protein family
Amet_3524	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Amet_3533	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_3534	COG0129	dihydroxy-acid dehydratase activity
Amet_3535	COG4753	response regulator
Amet_3535	COG2207	Transcriptional regulator
Amet_3537	COG3459	Glycosyltransferase 36 associated
Amet_3538	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Amet_3539	COG2234	aminopeptidase activity
Amet_3543	COG0803	Belongs to the bacterial solute-binding protein 9 family
Amet_3545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Amet_3551	COG0577	efflux transmembrane transporter activity
Amet_3552	COG1136	(ABC) transporter
Amet_3553	COG0577	efflux transmembrane transporter activity
Amet_3554	COG1136	(ABC) transporter
Amet_3555	COG2205	protein histidine kinase activity
Amet_3556	COG0745	RESPONSE REGULATOR receiver
Amet_3563	COG3279	Response regulator of the LytR AlgR family
Amet_3570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Amet_3572	COG0557	exoribonuclease II activity
Amet_3576	COG0148	phosphopyruvate hydratase activity
Amet_3578	COG0149	triose-phosphate isomerase activity
Amet_3579	COG0126	phosphoglycerate kinase activity
Amet_3581	COG2390	Transcriptional regulator
Amet_3582	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Amet_3586	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Amet_3587	COG1328	CTP reductase activity
Amet_3588	COG1744	ABC transporter substrate-binding protein PnrA-like
Amet_3594	COG3118	belongs to the thioredoxin family
Amet_3597	COG1307	EDD domain protein, DegV family
Amet_3598	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Amet_3601	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Amet_3602	COG0673	inositol 2-dehydrogenase activity
Amet_3604	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amet_3605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Amet_3609	COG0737	Belongs to the 5'-nucleotidase family
Amet_3610	COG0737	Belongs to the 5'-nucleotidase family
Amet_3613	COG0735	belongs to the Fur family
Amet_3614	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amet_3615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Amet_3616	COG1492	cobalamin metabolic process
Amet_3617	COG1120	ATPase activity
Amet_3618	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amet_3619	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Amet_3621	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Amet_3626	COG2720	vancomycin resistance protein
Amet_3628	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Amet_3633	COG0681	Belongs to the peptidase S26 family
Amet_3634	COG0156	8-amino-7-oxononanoate synthase activity
Amet_3635	COG1067	ATP-dependent peptidase activity
Amet_3637	COG0681	Belongs to the peptidase S26 family
Amet_3642	COG2066	Belongs to the glutaminase family
Amet_3644	COG0517	IMP dehydrogenase activity
Amet_3645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Amet_3646	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Amet_3647	COG0681	Belongs to the peptidase S26 family
Amet_3650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Amet_3652	COG2249	NAD(P)H dehydrogenase (quinone) activity
Amet_3653	COG3546	catalase activity
Amet_3656	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Amet_3657	COG0456	acetyltransferase
Amet_3658	COG0482	sulfurtransferase activity
Amet_3659	COG1126	abc transporter atp-binding protein
Amet_3660	COG0765	amino acid transport
Amet_3661	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amet_3662	COG0791	NLP P60 protein
Amet_3665	COG4187	Peptidase family M20/M25/M40
Amet_3669	COG1649	PFAM Uncharacterised BCR, COG1649
Amet_3672	COG1187	pseudouridine synthase activity
Amet_3674	COG1183	phosphatidylcholine synthase activity
Amet_3675	COG0191	fructose-bisphosphate aldolase activity
Amet_3678	COG2357	RelA SpoT domain protein
Amet_3682	COG1242	4 iron, 4 sulfur cluster binding
Amet_3686	COG1705	Flagellar rod assembly protein muramidase FlgJ
Amet_3686	COG1388	LysM domain
Amet_3688	COG2155	Conserved Protein
Amet_3690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amet_3692	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Amet_3694	COG0697	spore germination
Amet_3697	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Amet_3698	COG0745	RESPONSE REGULATOR receiver
Amet_3698	COG3706	GGDEF domain
Amet_3702	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_3706	COG0626	cystathionine gamma-synthase activity
Amet_3707	COG0626	cystathionine gamma-synthase activity
Amet_3709	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Amet_3710	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amet_3711	COG5002	protein histidine kinase activity
Amet_3715	COG2197	response regulator
Amet_3716	COG4585	Histidine kinase
Amet_3719	COG1131	(ABC) transporter
Amet_3723	COG0426	domain, Protein
Amet_3725	COG0038	chloride channel
Amet_3726	COG2323	membrane
Amet_3727	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Amet_3728	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Amet_3729	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_3731	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Amet_3736	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Amet_3737	COG1473	amidohydrolase
Amet_3739	COG4895	conserved protein (DUF2196)
Amet_3740	COG0697	spore germination
Amet_3742	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Amet_3744	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amet_3745	COG0405	Gamma-glutamyltransferase
Amet_3746	COG3875	lactate racemase activity
Amet_3747	COG0277	FAD linked oxidase domain protein
Amet_3748	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amet_3749	COG2086	electron transfer activity
Amet_3750	COG2186	Transcriptional regulator
Amet_3751	COG1620	l-lactate permease
Amet_3754	COG0840	transmembrane signaling receptor activity
Amet_3756	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Amet_3757	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Amet_3758	COG0235	Class ii aldolase
Amet_3760	COG0835	chemotaxis
Amet_3762	COG1131	(ABC) transporter
Amet_3764	COG1151	hydroxylamine reductase activity
Amet_3765	COG0437	4 iron, 4 sulfur cluster binding
Amet_3766	COG3829	transcription factor binding
Amet_3766	COG3290	protein histidine kinase activity
Amet_3767	COG1164	Oligoendopeptidase f
Amet_3769	COG1199	ATP-dependent helicase activity
Amet_3771	COG1120	ATPase activity
Amet_3772	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amet_3773	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amet_3774	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Amet_3776	COG0275	rRNA processing
Amet_3777	COG0840	transmembrane signaling receptor activity
Amet_3779	COG0653	protein targeting
Amet_3783	COG0246	Mannitol dehydrogenase
Amet_3784	COG1312	Catalyzes the dehydration of D-mannonate
Amet_3788	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Amet_3789	COG1802	Transcriptional regulator
Amet_3790	COG4279	zinc finger
Amet_3791	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Amet_3794	COG1070	Carbohydrate kinase
Amet_3795	COG1940	carbohydrate kinase activity
Amet_3796	COG2115	Belongs to the xylose isomerase family
Amet_3797	COG4214	carbohydrate transport
Amet_3799	COG4213	ABC transporter substrate-binding protein
Amet_3800	COG2017	converts alpha-aldose to the beta-anomer
Amet_3804	COG3279	Response regulator of the LytR AlgR family
Amet_3805	COG2972	Histidine kinase
Amet_3806	COG0534	Mate efflux family protein
Amet_3807	COG1132	(ABC) transporter
Amet_3812	COG1595	DNA-templated transcription, initiation
Amet_3818	COG2378	regulation of single-species biofilm formation
Amet_3822	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_3823	COG4869	propanediol catabolic process
Amet_3824	COG1012	belongs to the aldehyde dehydrogenase family
Amet_3824	COG1454	alcohol dehydrogenase
Amet_3825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_3828	COG4656	Part of a membrane complex involved in electron transport
Amet_3831	COG4820	ethanolamine utilization protein (EutJ)
Amet_3834	COG4810	utilization protein
Amet_3835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Amet_3836	COG1882	Formate acetyltransferase
Amet_3837	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_3838	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_3843	COG2972	Histidine kinase
Amet_3846	COG2207	Transcriptional regulator
Amet_3847	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Amet_3856	COG2119	membrane
Amet_3859	COG1053	succinate dehydrogenase
Amet_3859	COG3976	FMN-binding domain protein
Amet_3862	COG1309	transcriptional regulator
Amet_3863	COG1053	succinate dehydrogenase
Amet_3867	COG1132	(ABC) transporter
Amet_3876	COG0534	Mate efflux family protein
Amet_3881	COG0840	transmembrane signaling receptor activity
Amet_3891	COG3875	lactate racemase activity
Amet_3892	COG1464	Belongs to the NlpA lipoprotein family
Amet_3893	COG2011	ABC-type metal ion transport system permease component
Amet_3894	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Amet_3908	COG1131	(ABC) transporter
Amet_3934	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Amet_3935	COG0789	Transcriptional regulator
Amet_3942	COG1131	(ABC) transporter
Amet_3953	COG0577	efflux transmembrane transporter activity
Amet_3954	COG1136	(ABC) transporter
Amet_3955	COG0642	Histidine kinase
Amet_3956	COG0745	RESPONSE REGULATOR receiver
Amet_3975	COG1196	nuclear chromosome segregation
Amet_3993	COG1475	DNA binding
Amet_3994	COG1192	Involved in chromosome partitioning
Amet_3996	COG0798	PFAM Bile acid sodium symporter
Amet_4009	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amet_4009	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Amet_4030	COG4695	Portal protein
Amet_4033	COG1802	Transcriptional regulator
Amet_4033	COG4626	Terminase
Amet_4056	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Amet_4064	COG0824	Thioesterase
Amet_4069	COG0205	6-phosphofructokinase activity
Amet_4075	COG1428	Deoxynucleoside kinase
Amet_4076	COG1428	Deoxynucleoside kinase
Amet_4086	COG3290	protein histidine kinase activity
Amet_4088	COG1481	regulation of sporulation
Amet_4091	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Amet_4092	COG1660	Displays ATPase and GTPase activities
Amet_4093	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Amet_4096	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Amet_4098	COG3383	formate dehydrogenase (NAD+) activity
Amet_4103	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Amet_4104	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Amet_4105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Amet_4112	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amet_4114	COG2376	Dihydroxyacetone kinase
Amet_4116	COG0411	ABC transporter
Amet_4118	COG0559	Belongs to the binding-protein-dependent transport system permease family
Amet_4121	COG1940	carbohydrate kinase activity
Amet_4122	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Amet_4123	COG1983	PspC domain protein
Amet_4124	COG0322	excinuclease ABC activity
Amet_4126	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Amet_4127	COG0556	nucleotide-excision repair
Amet_4128	COG0793	Belongs to the peptidase S41A family
Amet_4129	COG0739	heme binding
Amet_4130	COG2177	Part of the ABC transporter FtsEX involved in
Amet_4131	COG2884	Cell division ATP-binding protein ftsE
Amet_4132	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Amet_4133	COG1067	ATP-dependent peptidase activity
Amet_4134	COG3942	CHAP domain
Amet_4134	COG1388	LysM domain
Amet_4138	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Amet_4139	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Amet_4143	COG2337	Toxic component of a toxin-antitoxin (TA) module
Amet_4147	COG0736	holo-[acyl-carrier-protein] synthase activity
Amet_4150	COG0651	ATP synthesis coupled electron transport
Amet_4151	COG0651	ATP synthesis coupled electron transport
Amet_4152	COG0651	ATP synthesis coupled electron transport
Amet_4154	COG2111	Na H antiporter
Amet_4158	COG2212	antiporter activity
Amet_4159	COG1863	multisubunit Na H antiporter MnhE subunit
Amet_4164	COG4555	ABC transporter
Amet_4166	COG0517	IMP dehydrogenase activity
Amet_4167	COG0419	ATPase involved in DNA repair
Amet_4168	COG0420	3'-5' exonuclease activity
Amet_4169	COG1074	ATP-dependent DNA helicase activity
Amet_4172	COG1136	(ABC) transporter
Amet_4172	COG0577	efflux transmembrane transporter activity
Amet_4176	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Amet_4180	COG1592	Rubrerythrin
Amet_4182	COG0363	glucosamine-6-phosphate deaminase activity
Amet_4183	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Amet_4184	COG3394	polysaccharide catabolic process
Amet_4185	COG1486	melibiose metabolic process
Amet_4186	COG1447	Phosphotransferase system cellobiose-specific component IIA
Amet_4187	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Amet_4188	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Amet_4189	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Amet_4190	COG1737	Transcriptional regulator
Amet_4191	COG2971	BadF BadG BcrA BcrD
Amet_4193	COG1447	Phosphotransferase system cellobiose-specific component IIA
Amet_4194	COG1486	melibiose metabolic process
Amet_4195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Amet_4197	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Amet_4197	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Amet_4198	COG0688	phosphatidylethanolamine metabolic process
Amet_4200	COG0540	Belongs to the ATCase OTCase family
Amet_4202	COG2197	response regulator
Amet_4203	COG4585	Histidine kinase
Amet_4206	COG1131	(ABC) transporter
Amet_4207	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Amet_4208	COG0167	dihydroorotate dehydrogenase activity
Amet_4209	COG0543	2 iron, 2 sulfur cluster binding
Amet_4212	COG0284	orotidine-5'-phosphate decarboxylase activity
Amet_4215	COG2362	D-Aminopeptidase
Amet_4216	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Amet_4217	COG0017	Asparaginyl-tRNA synthetase
Amet_4219	COG0789	Transcriptional regulator
Amet_4224	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amet_4228	COG0813	purine-nucleoside phosphorylase activity
Amet_4229	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Amet_4230	COG0534	Mate efflux family protein
Amet_4232	COG0352	thiamine-phosphate diphosphorylase activity
Amet_4233	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Amet_4235	COG2022	thiamine diphosphate biosynthetic process
Amet_4244	COG2851	Citrate transporter
Amet_4245	COG3290	protein histidine kinase activity
Amet_4245	COG3829	transcription factor binding
Amet_4247	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Amet_4248	COG3290	protein histidine kinase activity
Amet_4248	COG3829	transcription factor binding
Amet_4250	COG1595	DNA-templated transcription, initiation
Amet_4252	COG0726	polysaccharide deacetylase
Amet_4253	COG2309	aminopeptidase activity
Amet_4254	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Amet_4255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Amet_4256	COG0534	Mate efflux family protein
Amet_4258	COG1794	racemase activity, acting on amino acids and derivatives
Amet_4260	COG1272	protein, Hemolysin III
Amet_4262	COG1295	ribonuclease BN
Amet_4266	COG2154	pterin-4-alpha-carbinolamine dehydratase
Amet_4267	COG1063	alcohol dehydrogenase
Amet_4270	COG3711	transcriptional antiterminator
Amet_4274	COG0473	3-isopropylmalate dehydrogenase activity
Amet_4275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Amet_4282	COG0456	acetyltransferase
Amet_4288	COG1418	mRNA catabolic process
Amet_4291	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Amet_4299	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Amet_4300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Amet_4301	COG1966	Carbon starvation protein
Amet_4308	COG3426	butyrate kinase activity
Amet_4309	COG0280	phosphate acetyltransferase
Amet_4310	COG3426	butyrate kinase activity
Amet_4311	COG3829	transcription factor binding
Amet_4311	COG3290	protein histidine kinase activity
Amet_4313	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Amet_4316	COG5322	oxidoreductase activity
Amet_4316	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amet_4321	COG1971	Probably functions as a manganese efflux pump
Amet_4323	COG3852	Histidine kinase
Amet_4329	COG2119	membrane
Amet_4330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Amet_4334	COG2323	membrane
Amet_4335	COG1902	pentaerythritol trinitrate reductase activity
Amet_4336	COG1473	amidohydrolase
Amet_4337	COG0019	diaminopimelate decarboxylase activity
Amet_4339	COG1968	undecaprenyl-diphosphatase activity
Amet_4374	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_4374	COG3409	Peptidoglycan-binding domain 1 protein
Amet_4384	COG1191	sigma factor activity
Amet_4393	COG2842	Transposition protein
Amet_4402	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Amet_4403	COG1694	Mazg nucleotide pyrophosphohydrolase
Amet_4405	COG0367	asparagine synthase
Amet_4406	COG1253	flavin adenine dinucleotide binding
Amet_4407	COG5002	protein histidine kinase activity
Amet_4408	COG1376	ErfK ybiS ycfS ynhG family protein
Amet_4411	COG5002	protein histidine kinase activity
Amet_4415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Amet_4416	COG0569	domain protein
Amet_4420	COG4251	negative regulation of phosphorylation
Amet_4420	COG5001	Diguanylate cyclase
Amet_4420	COG3706	GGDEF domain
Amet_4420	COG2203	Gaf domain
Amet_4423	COG4978	Transcriptional regulator
Amet_4423	COG0789	Transcriptional regulator
Amet_4424	COG0010	Belongs to the arginase family
Amet_4425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Amet_4426	COG0321	lipoyl(octanoyl) transferase activity
Amet_4432	COG0583	DNA-binding transcription factor activity
Amet_4433	COG5002	protein histidine kinase activity
Amet_4435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Amet_4437	COG1592	Rubrerythrin
Amet_4438	COG2861	carbohydrate metabolic process
Amet_4440	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_4442	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Amet_4443	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Amet_4444	COG0101	tRNA pseudouridine synthase activity
Amet_4445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Amet_4447	COG1122	ATPase activity
Amet_4448	COG0203	ribosomal protein L17
Amet_4449	COG0202	RNA polymerase activity
Amet_4450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Amet_4451	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Amet_4452	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Amet_4453	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Amet_4454	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Amet_4456	COG0024	Methionine aminopeptidase
Amet_4457	COG0563	adenylate kinase activity
Amet_4458	COG0201	protein transport
Amet_4459	COG0200	Binds to the 23S rRNA
Amet_4460	COG1841	ribosomal large subunit assembly
Amet_4461	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Amet_4462	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Amet_4463	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Amet_4464	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Amet_4465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Amet_4466	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Amet_4467	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Amet_4468	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Amet_4469	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Amet_4470	COG0255	Belongs to the universal ribosomal protein uL29 family
Amet_4471	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Amet_4472	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Amet_4473	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Amet_4474	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Amet_4475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Amet_4476	COG0089	rRNA binding
Amet_4477	COG0088	Forms part of the polypeptide exit tunnel
Amet_4478	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Amet_4479	COG0051	transcription antitermination factor activity, RNA binding
Amet_4480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Amet_4481	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Amet_4482	COG0049	tRNA binding
Amet_4483	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Amet_4484	COG1358	cellular component organization or biogenesis
Amet_4485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Amet_4486	COG0085	RNA polymerase activity
Amet_4487	COG0222	ribosome binding
Amet_4488	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Amet_4489	COG0081	regulation of translation
Amet_4490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Amet_4491	COG0250	Participates in transcription elongation, termination and antitermination
Amet_4493	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Amet_4494	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Amet_4496	COG3688	RNA-binding protein containing a PIN domain
Amet_4497	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amet_4501	COG0215	cysteine-tRNA ligase activity
Amet_4502	COG1045	serine acetyltransferase
Amet_4503	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Amet_4503	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Amet_4504	COG4086	secreted protein
Amet_4505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Amet_4506	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Amet_4507	COG4956	integral membrane protein (PIN domain superfamily)
Amet_4508	COG1329	Transcriptional regulator
Amet_4510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Amet_4511	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Amet_4512	COG0542	response to heat
Amet_4513	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Amet_4514	COG3880	PFAM UvrB UvrC protein
Amet_4515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Amet_4516	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amet_4517	COG2032	superoxide dismutase activity
Amet_4519	COG0038	chloride channel
Amet_4523	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amet_4524	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Amet_4525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Amet_4527	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Amet_4528	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Amet_4530	COG0840	transmembrane signaling receptor activity
Amet_4531	COG2610	gluconate transmembrane transporter activity
Amet_4533	COG3829	transcription factor binding
Amet_4533	COG3290	protein histidine kinase activity
Amet_4534	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Amet_4534	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Amet_4535	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Amet_4536	COG0511	ligase activity, forming carbon-carbon bonds
Amet_4538	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amet_4539	COG0346	lactoylglutathione lyase activity
Amet_4541	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amet_4541	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amet_4543	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amet_4546	COG2304	oxidoreductase activity
Amet_4548	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amet_4549	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Amet_4550	COG1193	negative regulation of DNA recombination
Amet_4553	COG0604	alcohol dehydrogenase
Amet_4554	COG3829	transcription factor binding
Amet_4555	COG0116	Belongs to the methyltransferase superfamily
Amet_4558	COG1408	metallophosphoesterase
Amet_4560	COG1151	hydroxylamine reductase activity
Amet_4562	COG0436	Aminotransferase
Amet_4563	COG3608	succinylglutamate desuccinylase aspartoacylase
Amet_4563	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Amet_4564	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Amet_4564	COG3608	succinylglutamate desuccinylase aspartoacylase
Amet_4565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Amet_4567	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Amet_4572	COG0402	S-adenosylhomocysteine deaminase activity
Amet_4573	COG2252	PERMEase
Amet_4574	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Amet_4577	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_4580	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Amet_4581	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Amet_4582	COG0163	prenyltransferase activity
Amet_4585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Amet_4587	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Amet_4588	COG3835	regulator
Amet_4589	COG3404	Formiminotransferase-cyclodeaminase
Amet_4591	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amet_4597	COG0814	amino acid
Amet_4598	COG0814	amino acid
Amet_4600	COG0697	spore germination
Amet_4602	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Amet_4604	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Amet_4608	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Amet_4609	COG2235	arginine
Amet_4610	COG4466	Protein conserved in bacteria
Amet_4611	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amet_4612	COG1846	Transcriptional regulator
Amet_4616	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Amet_4619	COG1053	succinate dehydrogenase
Amet_4619	COG0431	NADPH-dependent FMN reductase
Amet_4619	COG3976	FMN-binding domain protein
Amet_4620	COG0704	Plays a role in the regulation of phosphate uptake
Amet_4621	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Amet_4622	COG0581	inorganic phosphate transmembrane transporter activity
Amet_4623	COG0573	inorganic phosphate transmembrane transporter activity
Amet_4624	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Amet_4625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Amet_4627	COG3842	ATPase activity
Amet_4630	COG0183	Belongs to the thiolase family
Amet_4631	COG1028	Short-chain dehydrogenase reductase Sdr
Amet_4632	COG0628	permease
Amet_4633	COG2323	membrane
Amet_4638	COG0840	transmembrane signaling receptor activity
Amet_4643	COG2414	aldehyde ferredoxin oxidoreductase
Amet_4646	COG3383	formate dehydrogenase (NAD+) activity
Amet_4648	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Amet_4650	COG0653	protein targeting
Amet_4651	COG0534	Mate efflux family protein
Amet_4653	COG2033	superoxide reductase activity
Amet_4655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Amet_4657	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amet_4657	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amet_4657	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Amet_4657	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amet_4658	COG1132	(ABC) transporter
Amet_4663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Amet_4663	COG0723	plastoquinol--plastocyanin reductase activity
Amet_4665	COG3681	Belongs to the UPF0597 family
Amet_4667	COG2070	2-Nitropropane dioxygenase
Amet_4671	COG1309	transcriptional regulator
Amet_4675	COG1917	Cupin 2, conserved barrel domain protein
Amet_4675	COG4977	sequence-specific DNA binding
Amet_4683	COG1595	DNA-templated transcription, initiation
Amet_4693	COG1595	DNA-templated transcription, initiation
Amet_4695	COG0514	ATP-dependent DNA helicase (RecQ)
Amet_4696	COG0346	lactoylglutathione lyase activity
Amet_4698	COG1187	pseudouridine synthase activity
Amet_4699	COG0513	Belongs to the DEAD box helicase family
Amet_4709	COG2391	methyltransferase activity
Amet_4711	COG2391	methyltransferase activity
Amet_4714	COG0697	spore germination
Amet_4715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Amet_4718	COG1124	(ABC) transporter
Amet_4719	COG0444	Belongs to the ABC transporter superfamily
Amet_4722	COG0747	negative chemotaxis
Amet_4723	COG2814	Major facilitator Superfamily
Amet_4725	COG2514	catechol 2,3-dioxygenase activity
Amet_4726	COG0456	acetyltransferase
Amet_4728	COG0697	spore germination
Amet_4729	COG0745	RESPONSE REGULATOR receiver
Amet_4738	COG3842	ATPase activity
Amet_4742	COG0395	ABC-type sugar transport system, permease component
Amet_4743	COG1175	transmembrane transport
Amet_4744	COG1136	(ABC) transporter
Amet_4745	COG0577	efflux transmembrane transporter activity
Amet_4746	COG5002	protein histidine kinase activity
Amet_4747	COG0745	RESPONSE REGULATOR receiver
Amet_4749	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Amet_4751	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Amet_4752	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Amet_4758	COG0745	RESPONSE REGULATOR receiver
Amet_4760	COG1404	Belongs to the peptidase S8 family
Amet_4761	COG0739	heme binding
Amet_4765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Amet_4768	COG0305	Participates in initiation and elongation during chromosome replication
Amet_4769	COG0359	binds to the 23S rRNA
Amet_4770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Amet_4773	COG4129	membrane
Amet_4776	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Amet_4779	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Amet_4780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Amet_4781	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Amet_4784	COG3949	Membrane
Amet_4787	COG1597	lipid kinase activity
Amet_4789	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amet_4790	COG0384	phenazine biosynthesis protein PhzF
Amet_4791	COG1475	DNA binding
Amet_4792	COG1192	Involved in chromosome partitioning
Amet_4795	COG0357	Ribosomal RNA small subunit methyltransferase G
Amet_4796	COG0445	tRNA wobble uridine modification
Amet_4797	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Amet_4798	COG1847	R3H domain protein
Amet_4799	COG0706	membrane insertase activity
Amet_4800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Amet_4801	COG0594	ribonuclease P activity
Amet_4802	COG0230	Belongs to the bacterial ribosomal protein bL34 family