locus-tag	class	description
Clos_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Clos_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Clos_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Clos_0006	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Clos_0007	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Clos_0008	ENOG4105WN5	stage II sporulation protein
Clos_0009	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
Clos_0011	ENOG4108Z3G	3H domain protein
Clos_0014	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Clos_0018	ENOG4108Z6B	deaminase
Clos_0019	ENOG4105DF9	Lipoate-protein, ligase
Clos_0022	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Clos_0025	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Clos_0026	ENOG4108JUB	Transcriptional regulator
Clos_0027	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Clos_0028	ENOG41088D5	d-proline reductase
Clos_0031	ENOG41088D5	d-proline reductase
Clos_0032	ENOG41088D5	d-proline reductase
Clos_0033	ENOG4105CTU	Proline racemase
Clos_0035	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Clos_0036	ENOG4108UUM	single-stranded DNA-binding protein
Clos_0037	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Clos_0042	ENOG4105E2X	shikimate dehydrogenase
Clos_0044	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Clos_0045	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Clos_0052	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_0053	ENOG4105VPX	protein, conserved in bacteria
Clos_0054	ENOG4105C59	p-type ATPase
Clos_0056	ENOG4105ID8	Transcriptional regulator, ARAC family
Clos_0057	ENOG4105HHA	aminodeoxychorismate lyase
Clos_0059	ENOG4105CXN	decarboxylase
Clos_0060	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Clos_0061	ENOG4105X0R	protein from nitrogen regulatory protein P-II
Clos_0062	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Clos_0063	ENOG4105MA4	psp1 domain protein
Clos_0064	ENOG4105BZ8	glutamate synthase
Clos_0065	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Clos_0066	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Clos_0067	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Clos_0068	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Clos_0072	ENOG4105CKM	Branched-chain carboxylic acid kinase
Clos_0073	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Clos_0075	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Clos_0078	ENOG4105SYT	Methylenetetrahydrofolate reductase
Clos_0082	ENOG4105K7K	Transcriptional regulator
Clos_0084	ENOG4105CHU	acetyl-coa acetyltransferase
Clos_0085	ENOG4108JUB	Transcriptional regulator
Clos_0086	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
Clos_0087	ENOG4105CY2	Citrate transporter
Clos_0088	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Clos_0089	ENOG4105CHR	reductase
Clos_0090	ENOG4108Z7G	MaoC domain protein dehydratase
Clos_0091	ENOG4105C1G	acyl-Coa dehydrogenase
Clos_0092	ENOG4105BZJ	Electron transfer flavoprotein
Clos_0093	ENOG4105C10	Electron transfer flavoprotein
Clos_0095	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_0096	ENOG4105BZU	Histidine kinase
Clos_0101	ENOG4105C5H	ABC transporter
Clos_0108	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Clos_0113	ENOG4105EC3	peptidase S51, dipeptidase E
Clos_0120	ENOG4108HK0	-acetyltransferase
Clos_0121	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_0125	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Clos_0126	ENOG4108UMI	ABC transporter, permease
Clos_0127	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Clos_0128	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Clos_0129	ENOG4105II7	pyrroline-5-carboxylate reductase
Clos_0141	ENOG4105C19	ABC transporter
Clos_0142	ENOG4107RBB	ABC transporter, permease
Clos_0145	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Clos_0148	ENOG4107S16	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
Clos_0149	ENOG4107T0D	ABC, transporter
Clos_0152	ENOG4105DQ6	Transposase
Clos_0155	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Clos_0163	ENOG410904A	RNA polymerase
Clos_0165	ENOG4105E39	Enoyl-CoA hydratase
Clos_0166	ENOG4105CY2	Citrate transporter
Clos_0167	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
Clos_0169	ENOG4105BZJ	Electron transfer flavoprotein
Clos_0170	ENOG4105C10	Electron transfer flavoprotein
Clos_0171	ENOG4108JUB	Transcriptional regulator
Clos_0176	ENOG4105CX6	glutaminyL-tRNA synthetase
Clos_0177	ENOG4105UQX	Mate efflux family protein
Clos_0178	ENOG4107EFR	Flavocytochrome c
Clos_0179	ENOG4105C2F	Histidine kinase
Clos_0180	ENOG4107VQW	regulatoR
Clos_0182	ENOG4105DR5	peptidase
Clos_0183	ENOG4108HW3	(ABC) transporter
Clos_0184	ENOG4105EAD	ABC transporter
Clos_0185	ENOG4105CDA	abc transporter atp-binding protein
Clos_0186	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_0187	ENOG4108JUB	Transcriptional regulator
Clos_0190	ENOG4108UMN	azlc family
Clos_0191	ENOG4105KMT	branched-chain amino acid
Clos_0195	ENOG4105EHG	Permease protein
Clos_0196	ENOG4105E0A	ABC, transporter
Clos_0203	ENOG4105BZU	Histidine kinase
Clos_0204	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Clos_0207	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Clos_0208	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Clos_0209	ENOG4105CBC	glutamate synthase
Clos_0210	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Clos_0213	ENOG4105EHG	Permease protein
Clos_0214	ENOG4105E0A	ABC, transporter
Clos_0215	ENOG4105S10	periplasmic binding protein
Clos_0217	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Clos_0220	ENOG4105S10	periplasmic binding protein
Clos_0221	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
Clos_0227	ENOG41066UZ	arginase EC 3.5.3.1
Clos_0231	ENOG4105BZU	Histidine kinase
Clos_0232	ENOG4105CU9	asparagine synthetase A
Clos_0233	ENOG4105BZ1	(ABC) transporter
Clos_0237	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Clos_0238	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Clos_0239	ENOG4108YZ8	Superoxide reductase
Clos_0241	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_0242	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Clos_0244	ENOG4105C3S	Mate efflux family protein
Clos_0245	ENOG4108J2R	molybdopterin oxidoreductase
Clos_0249	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Clos_0250	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_0256	ENOG4105C02	permease
Clos_0257	ENOG4105CHR	reductase
Clos_0258	ENOG4105CHU	acetyl-coa acetyltransferase
Clos_0260	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
Clos_0265	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_0266	ENOG4105CVA	phosphate
Clos_0267	ENOG4105C8U	phosphate abc transporter
Clos_0268	ENOG4105E2Z	phosphate ABC transporter (Permease
Clos_0269	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Clos_0270	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Clos_0271	ENOG4108U5J	'-nucleotidase
Clos_0273	ENOG4107EFR	Flavocytochrome c
Clos_0274	ENOG4105DFD	Na H antiporter
Clos_0276	ENOG4107QIZ	NADH dehydrogenase
Clos_0278	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Clos_0282	ENOG4105W42	Veg protein
Clos_0285	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Clos_0286	ENOG4105DRR	Transcriptional regulator, GntR family
Clos_0290	ENOG4108Q5U	germination protein, ger(x)c family
Clos_0291	ENOG4108ZXQ	stage ii sporulation protein r
Clos_0292	ENOG4105CPF	Cell wall formation (By similarity)
Clos_0295	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
Clos_0297	ENOG4108K60	carbamoyl-phosphate synthetase ammonia chain
Clos_0298	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Clos_0299	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Clos_0300	ENOG4105K4I	Scp-like extracellular
Clos_0301	ENOG4105DCG	PHP domain protein
Clos_0303	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Clos_0305	ENOG4105KRS	Proteinase inhibitor
Clos_0307	ENOG41075H3	AraC family transcriptional regulator
Clos_0309	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Clos_0311	ENOG4105DQ5	transport system permease protein
Clos_0313	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
Clos_0317	ENOG4105E1K	spore germination protein
Clos_0319	ENOG4108U1V	ABC transporter, permease
Clos_0320	ENOG4105E0A	ABC, transporter
Clos_0321	ENOG4105CJ1	ABC, transporter
Clos_0322	ENOG4105E3A	(ABC) transporter
Clos_0323	ENOG4107PPM	cobalt chelatase
Clos_0324	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Clos_0325	ENOG4105BZU	Histidine kinase
Clos_0326	ENOG4108Z5K	methylglyoxal synthase
Clos_0331	ENOG4105UQX	Mate efflux family protein
Clos_0337	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Clos_0340	ENOG4105KKJ	Aminoglycoside phosphotransferase
Clos_0341	ENOG41068WN	
Clos_0348	ENOG4105MA6	gCN5-related N-acetyltransferase
Clos_0354	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_0358	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Clos_0360	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
Clos_0363	ENOG4108RWI	nicotinamidase
Clos_0364	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Clos_0365	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Clos_0366	ENOG4105KNY	Microcompartments protein
Clos_0368	ENOG4105KNY	Microcompartments protein
Clos_0369	ENOG4105KNY	Microcompartments protein
Clos_0372	ENOG4105CPN	adenine deaminase
Clos_0373	ENOG4105C7N	Xanthine uracil vitamin C permease
Clos_0374	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Clos_0379	ENOG4105CPN	adenine deaminase
Clos_0382	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Clos_0383	ENOG4105CXN	decarboxylase
Clos_0384	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Clos_0385	ENOG4108NVR	Methyl-accepting chemotaxis
Clos_0386	ENOG4108S4H	thioesterase Superfamily protein
Clos_0388	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Clos_0391	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Clos_0393	ENOG4105NBU	tryptophan transport protein
Clos_0395	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Clos_0396	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Clos_0397	ENOG4108FRU	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Clos_0398	ENOG4105KHC	sulfurtransferase
Clos_0399	ENOG4108UT2	hemolysin iii
Clos_0401	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
Clos_0402	ENOG4105CH2	amidohydrolase
Clos_0404	ENOG4105HF9	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Clos_0407	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Clos_0408	ENOG4105VRS	hydrolase family 18
Clos_0410	ENOG41064RH	membrane protein YliF
Clos_0411	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Clos_0415	ENOG4107RGJ	metallophosphoesterase
Clos_0416	ENOG4108JUB	Transcriptional regulator
Clos_0417	ENOG4105FRY	Dehydrogenase
Clos_0420	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Clos_0421	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
Clos_0422	ENOG4107CHF	5,6-aminomutase beta subunit
Clos_0426	ENOG4105DY9	regulatoR
Clos_0431	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Clos_0432	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Clos_0433	ENOG4105D0C	transport protein
Clos_0435	ENOG4105CYC	Transferase
Clos_0436	ENOG4105D5P	Methylmalonyl-coA mutase
Clos_0437	ENOG4105D5P	Methylmalonyl-coA mutase
Clos_0439	ENOG4108ZVT	methylmalonyl-coA epimerase
Clos_0440	ENOG4107QX3	carboxylase
Clos_0442	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
Clos_0443	ENOG4105D9Q	decarboxylase (Beta subunit)
Clos_0444	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Clos_0446	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Clos_0447	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Clos_0449	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Clos_0450	ENOG4105CRK	lysyL-tRNA synthetase
Clos_0452	ENOG4108IAX	Ribonucleoside-triphosphate reductase
Clos_0453	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Clos_0454	ENOG4108Z0C	Uvrb UvrC protein
Clos_0455	ENOG41066A3	ATP guanido phosphotransferase
Clos_0456	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Clos_0457	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Clos_0460	ENOG4108VJ1	Transcriptional regulator (CarD family
Clos_0461	ENOG4105CTP	PilT protein domain protein
Clos_0463	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Clos_0464	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Clos_0465	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Clos_0466	ENOG4105PTM	secreted protein
Clos_0467	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Clos_0468	ENOG4105D7W	serine acetyltransferase
Clos_0469	ENOG4105C8N	cysteinyl-tRNA synthetase
Clos_0472	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Clos_0473	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Clos_0474	ENOG4105M0M	Tetracycline resistance protein
Clos_0475	ENOG4105QIV	RNA polymerase
Clos_0476	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Clos_0477	ENOG4105WDJ	50S ribosomal protein L33
Clos_0479	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Clos_0480	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Clos_0481	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Clos_0482	ENOG4108VZM	50s ribosomal protein L10
Clos_0483	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Clos_0484	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Clos_0485	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Clos_0486	ENOG4105XPM	ribosomal protein
Clos_0487	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Clos_0488	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Clos_0489	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Clos_0490	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Clos_0491	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Clos_0492	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Clos_0493	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Clos_0494	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Clos_0495	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Clos_0496	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Clos_0497	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Clos_0498	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Clos_0499	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Clos_0500	ENOG41082SA	50s ribosomal protein l29
Clos_0501	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Clos_0502	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Clos_0503	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Clos_0504	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Clos_0505	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Clos_0506	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Clos_0507	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Clos_0508	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Clos_0509	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Clos_0510	ENOG4105VPB	50S ribosomal protein L30
Clos_0511	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Clos_0512	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Clos_0513	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Clos_0514	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Clos_0516	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Clos_0517	ENOG41067V7	50S ribosomal protein L36
Clos_0518	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Clos_0519	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Clos_0520	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Clos_0521	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Clos_0522	ENOG4108ZT0	50S ribosomal protein l17
Clos_0523	ENOG4108JJB	ABC transporter
Clos_0524	ENOG4108JJB	ABC transporter
Clos_0525	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Clos_0526	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Clos_0527	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Clos_0528	ENOG4108UJD	30S ribosomal protein S9
Clos_0530	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Clos_0533	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Clos_0534	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Clos_0535	ENOG4105C7N	Xanthine uracil vitamin C permease
Clos_0536	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Clos_0537	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Clos_0539	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Clos_0540	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Clos_0541	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Clos_0542	ENOG4105C12	Phosphoribosylglycinamide synthetase
Clos_0543	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_0544	ENOG4105D01	(LipO)protein
Clos_0547	ENOG4105CG9	aspartate racemase
Clos_0548	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Clos_0549	ENOG4105C4R	Atp-dependent dna helicase
Clos_0550	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Clos_0555	ENOG4108U5N	UPF0316 protein
Clos_0557	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Clos_0558	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Clos_0559	ENOG4105M59	Phosphodiesterase, mj0936 family
Clos_0562	ENOG4108RAV	Conserved protein
Clos_0567	ENOG4105CIN	aminoacyl-histidine dipeptidase
Clos_0569	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
Clos_0570	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Clos_0573	ENOG4105D4A	Cell wall formation (By similarity)
Clos_0574	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Clos_0575	ENOG4105CHW	UPF0052 protein
Clos_0578	ENOG4105CIE	May be required for sporulation (By similarity)
Clos_0579	ENOG4105CGP	Urocanate hydratase
Clos_0580	ENOG4105CCS	Glutamate formiminotransferase
Clos_0582	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Clos_0583	ENOG4105C0B	DNA polymerase III (alpha subunit)
Clos_0585	ENOG4105CTQ	phosphohexokinase
Clos_0586	ENOG4105CA9	Pyruvate kinase
Clos_0587	ENOG4107Z3H	Transcriptional regulator, TetR family
Clos_0588	ENOG4107EFR	Flavocytochrome c
Clos_0590	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Clos_0592	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Clos_0595	ENOG4105DQ6	Transposase
Clos_0601	ENOG4105I1F	Resistance protein
Clos_0602	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
Clos_0604	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Clos_0610	ENOG4105C08	Histidine kinase
Clos_0611	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
Clos_0614	ENOG4107QJZ	Glycosyl transferase, family 2
Clos_0617	ENOG4108RAC	Rubrerythrin
Clos_0620	ENOG4108Z7R	Chaperone CsaA
Clos_0622	ENOG4105D0C	transport protein
Clos_0623	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Clos_0624	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Clos_0625	ENOG4105BZU	Histidine kinase
Clos_0626	ENOG4105C26	Dehydrogenase
Clos_0628	ENOG4105K95	(LipO)protein
Clos_0629	ENOG4105C2J	ABC transporter
Clos_0632	ENOG41080E8	Transcriptional regulator, Spx MgsR family
Clos_0635	ENOG4105CRW	Short chain fatty acid transporter
Clos_0636	ENOG4105C1G	acyl-Coa dehydrogenase
Clos_0637	ENOG4105BZJ	Electron transfer flavoprotein
Clos_0638	ENOG4105C10	Electron transfer flavoprotein
Clos_0639	ENOG4107TVC	Glycosyl transferase, family 2
Clos_0642	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
Clos_0645	ENOG4105FDP	GntR family transcriptional regulator
Clos_0649	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Clos_0651	ENOG4105DD7	kinase (PfkB family
Clos_0653	ENOG4105K63	Thioredoxin
Clos_0654	ENOG4105C3M	thioredoxin reductase
Clos_0655	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
Clos_0658	ENOG4105DPN	Oligoendopeptidase f
Clos_0660	ENOG4105CAK	Cell division ATP-binding protein ftsE
Clos_0661	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Clos_0662	ENOG4107XGZ	Hydrolase
Clos_0665	ENOG4107TXC	Transcriptional regulator
Clos_0668	ENOG4105F3H	Histidine kinase
Clos_0670	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Clos_0671	ENOG4108JU6	CBS domain protein
Clos_0672	ENOG4105C5H	ABC transporter
Clos_0673	ENOG4105C1A	potassium transporter peripheral membrane
Clos_0674	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Clos_0675	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Clos_0679	ENOG4108VW9	Membrane
Clos_0680	ENOG4108VXD	carboxy-peptidase
Clos_0682	ENOG4105E7U	AraC family transcriptional regulator
Clos_0684	ENOG4105BZ1	(ABC) transporter
Clos_0685	ENOG4105BZ1	(ABC) transporter
Clos_0686	ENOG4105BZU	Histidine kinase
Clos_0688	ENOG4105F32	YngK protein
Clos_0689	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Clos_0690	ENOG4105C34	Pseudouridine synthase
Clos_0691	ENOG4105EEM	helicase
Clos_0692	ENOG4107QW4	alcohol dehydrogenase
Clos_0694	ENOG4105JVQ	RNA Polymerase
Clos_0697	ENOG4108TTB	tellurium resistance protein
Clos_0701	ENOG4108N0M	stress protein
Clos_0702	ENOG4106FN3	tellurium resistance protein
Clos_0708	ENOG4105CZV	ABC transporter
Clos_0711	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Clos_0712	ENOG4105C5I	Dehydrogenase
Clos_0715	ENOG4105N5T	Radical SAM Protein
Clos_0719	ENOG4105D2N	Aldolase
Clos_0720	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Clos_0722	ENOG4107R0W	ABC transporter
Clos_0723	ENOG4105E5Q	amino acid AbC transporter
Clos_0725	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Clos_0729	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Clos_0736	ENOG4105DQ6	Transposase
Clos_0744	ENOG4105EGI	Transcriptional regulator
Clos_0745	ENOG4105JAB	phenazine biosynthesis protein, phzf family
Clos_0748	ENOG4105BZU	Histidine kinase
Clos_0750	ENOG4105BZG	amino acid carrier protein
Clos_0752	ENOG4108WUH	Transcriptional regulator, TetR family
Clos_0753	ENOG4105E8G	Major facilitator Superfamily
Clos_0755	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Clos_0756	ENOG4107TXC	Transcriptional regulator
Clos_0758	ENOG4105NAE	bifunctional deaminase-reductase domain protein
Clos_0760	ENOG4105CCI	Myosin-Cross-Reactive Antigen
Clos_0766	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Clos_0769	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Clos_0771	ENOG41075D4	Aminoglycoside 6-adenylyltransferase
Clos_0776	ENOG4105WG9	Conserved Protein
Clos_0780	ENOG4107TXC	Transcriptional regulator
Clos_0782	ENOG4105NAF	rna polymerase sigma factor
Clos_0785	ENOG4108U05	Transcriptional regulator
Clos_0787	ENOG4105F44	Two component transcriptional regulator, winged helix family
Clos_0788	ENOG4105GR3	Histidine kinase
Clos_0789	ENOG4107QX9	Thiol disulfide interChange protein
Clos_0791	ENOG4108VJN	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
Clos_0792	ENOG4106S4J	ethanolamine utilization protein EutP
Clos_0793	ENOG4108WBT	adenosyltransferase
Clos_0795	ENOG4105M3W	utilization protein
Clos_0796	ENOG4105DYY	Reactivating factor for ethanolamine ammonia lyase
Clos_0797	ENOG4105CPD	ethanolamine ammonia-lyase
Clos_0799	ENOG4106D67	ethanolamine utilization protein
Clos_0800	ENOG4105KNY	Microcompartments protein
Clos_0801	ENOG4108EKI	Dehydrogenase
Clos_0802	ENOG4105KNY	Microcompartments protein
Clos_0804	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
Clos_0806	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Clos_0807	ENOG4105ENY	Ethanolamine utilization protein eutH
Clos_0808	ENOG4105NDK	ethanolamine utilization protein
Clos_0813	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Clos_0815	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Clos_0816	ENOG4105D29	Helix-turn-helix type 11 domain protein
Clos_0821	ENOG4105BZ1	(ABC) transporter
Clos_0822	ENOG41090E6	transcriptional regulator MERR family
Clos_0823	ENOG4105DIN	metallophosphoesterase
Clos_0824	ENOG4107R6U	sodium dicarboxylate symporter
Clos_0825	ENOG4105C6T	cysteine synthase
Clos_0826	ENOG4105FQP	Beta-lactamase
Clos_0828	ENOG4105FGV	Chromate
Clos_0830	ENOG4105DUM	transcriptional regulator, lysR family
Clos_0831	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
Clos_0833	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
Clos_0834	ENOG4105BZU	Histidine kinase
Clos_0836	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
Clos_0838	ENOG4108IPJ	Membrane
Clos_0839	ENOG4107RBI	VanW family
Clos_0841	ENOG4105CXN	decarboxylase
Clos_0845	ENOG4105DWD	nucleoside recognition domain protein
Clos_0847	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
Clos_0848	ENOG41067TZ	transcriptional regulator, MarR family
Clos_0849	ENOG4105CHR	reductase
Clos_0850	ENOG4105MEV	Acyl-transferase
Clos_0852	ENOG4105EUB	pirin domain protein
Clos_0853	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
Clos_0854	ENOG4107YHD	transcriptional regulator
Clos_0860	ENOG4105C08	Histidine kinase
Clos_0861	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
Clos_0862	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Clos_0863	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Clos_0864	ENOG4105EFZ	amidohydrolase
Clos_0865	ENOG4107R7I	amino acid
Clos_0867	ENOG4105C2W	permease
Clos_0870	ENOG4105G5A	Protein of unknown function (DUF2877)
Clos_0871	ENOG4107R1Q	Membrane protein FdrA
Clos_0872	ENOG4107R1Q	Membrane protein FdrA
Clos_0873	ENOG4107REC	cytoplasmic protein
Clos_0875	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
Clos_0880	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Clos_0881	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_0882	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
Clos_0883	ENOG4105UQX	Mate efflux family protein
Clos_0884	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Clos_0891	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Clos_0895	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Clos_0897	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_0898	ENOG4107ZE5	PPIases accelerate the folding of proteins
Clos_0899	ENOG4105WEF	catalase
Clos_0907	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Clos_0908	ENOG4105DAN	ATP-dependent protease
Clos_0909	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Clos_0910	ENOG4105CSM	endonuclease III
Clos_0911	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Clos_0912	ENOG41073R8	VanW family
Clos_0915	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Clos_0916	ENOG4105EHG	Permease protein
Clos_0917	ENOG4105E0A	ABC, transporter
Clos_0918	ENOG4105I3K	Ferric uptake regulator, Fur family
Clos_0919	ENOG410667J	hydrolase
Clos_0920	ENOG4105CGH	5'-nucleotidase
Clos_0927	ENOG4105DTQ	mandelate racemase muconate lactonizing
Clos_0928	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
Clos_0929	ENOG4107QIZ	NADH dehydrogenase
Clos_0930	ENOG4107QHI	-hydrogenase
Clos_0934	ENOG4105E2Y	ABC, transporter
Clos_0935	ENOG4105CUY	Mechanosensitive ion channel
Clos_0936	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Clos_0937	ENOG4108Z66	YbaK ebsC protein
Clos_0943	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_0944	ENOG4105GR3	Histidine kinase
Clos_0946	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Clos_0949	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
Clos_0950	ENOG4105E0A	ABC, transporter
Clos_0952	ENOG4105EPR	degv family
Clos_0955	ENOG41080XV	Thioredoxin
Clos_0961	ENOG4107TFB	basic membrane
Clos_0962	ENOG4105G0K	glycine radical enzyme YjjI family
Clos_0963	ENOG41076CZ	activating enzyme
Clos_0964	ENOG4108JQ9	ABC transporter
Clos_0965	ENOG4105UIB	(ABC) transporter
Clos_0967	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_0970	ENOG4105BZA	Phosphoglycerate kinase
Clos_0971	ENOG4105CP7	Triose-phosphate isomerase
Clos_0972	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Clos_0973	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Clos_0975	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Clos_0976	ENOG410696E	Membrane
Clos_0977	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Clos_0978	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Clos_0979	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Clos_0980	ENOG4105C19	ABC transporter
Clos_0982	ENOG4105CJZ	response regulator
Clos_0986	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Clos_0989	ENOG4107QIZ	NADH dehydrogenase
Clos_0990	ENOG4107QHI	-hydrogenase
Clos_0991	ENOG4107QW8	radical SAM domain protein
Clos_0993	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Clos_0994	ENOG4105C34	Pseudouridine synthase
Clos_0995	ENOG4105DHI	Methyltransferase
Clos_0996	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Clos_0999	ENOG4105BZU	Histidine kinase
Clos_1001	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Clos_1002	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Clos_1003	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Clos_1005	ENOG41088CC	tellurite resistance protein tehB
Clos_1006	ENOG4108ME1	Peptidase M55 D-aminopeptidase
Clos_1009	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Clos_1011	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Clos_1012	ENOG4105W4R	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Clos_1013	ENOG4108V4M	Cobalt abc transporter
Clos_1014	ENOG4108JJB	ABC transporter
Clos_1015	ENOG41081F0	Precorrin-8x methylmutase
Clos_1016	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Clos_1017	ENOG4108DR9	Cobalt-precorrin-6Y C(5)-methyltransferase
Clos_1018	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
Clos_1019	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Clos_1020	ENOG4108P62	biosynthesis protein (CbiG)
Clos_1021	ENOG4105E4R	Precorrin-3B C17-methyltransferase
Clos_1022	ENOG4108JTQ	reductase
Clos_1023	ENOG4105DVK	Precorrin-2 c20-methyltransferase
Clos_1024	ENOG4105CAH	Chromate
Clos_1026	ENOG4105DUM	transcriptional regulator, lysR family
Clos_1027	ENOG41066VF	YeeE YedE family protein
Clos_1029	ENOG41066VF	YeeE YedE family protein
Clos_1030	ENOG4105DUM	transcriptional regulator, lysR family
Clos_1035	ENOG41067TZ	transcriptional regulator, MarR family
Clos_1037	ENOG4107QN2	dihydrolipoyl dehydrogenase
Clos_1038	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Clos_1039	ENOG4105C0D	helicase
Clos_1042	ENOG41067S9	phage shock protein C, PspC
Clos_1045	ENOG4105DZ6	Band 7 protein
Clos_1046	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
Clos_1056	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_1066	ENOG4105C59	p-type ATPase
Clos_1074	ENOG4105C28	cystathionine
Clos_1075	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
Clos_1076	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
Clos_1078	ENOG4105BZU	Histidine kinase
Clos_1079	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Clos_1083	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Clos_1084	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Clos_1087	ENOG4105C59	p-type ATPase
Clos_1092	ENOG4105CJ1	ABC, transporter
Clos_1093	ENOG410904A	RNA polymerase
Clos_1094	ENOG41089UC	methyltransferase, type 11
Clos_1095	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Clos_1096	ENOG4105C3J	Cysteine desulfurase
Clos_1097	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Clos_1099	ENOG4105QAX	Iron-sulfur
Clos_1101	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Clos_1103	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Clos_1114	ENOG4105D6J	arsenicaL-resistance protein
Clos_1117	ENOG4105C8U	phosphate abc transporter
Clos_1118	ENOG4105E2Z	phosphate ABC transporter (Permease
Clos_1119	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Clos_1120	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Clos_1123	ENOG4107S21	permease
Clos_1132	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Clos_1134	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Clos_1136	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
Clos_1137	ENOG4107KMQ	bfd domain protein (2fe-2s)-binding domain protein
Clos_1140	ENOG4105KT7	mgtC SapB transporter
Clos_1144	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Clos_1148	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
Clos_1152	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Clos_1158	ENOG4108VX5	3-methyladenine DNA glycosylase
Clos_1159	ENOG4105DMF	Dehydrogenase
Clos_1160	ENOG4107VMI	polysaccharide deacetylase
Clos_1161	ENOG4105F0V	Cell wall hydrolase
Clos_1162	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Clos_1163	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Clos_1164	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Clos_1166	ENOG4105DPN	Oligoendopeptidase f
Clos_1170	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Clos_1171	ENOG4105EMS	pseudouridine synthase
Clos_1173	ENOG4105IU0	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Clos_1180	ENOG4105BZ1	(ABC) transporter
Clos_1181	ENOG4105BZ1	(ABC) transporter
Clos_1183	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Clos_1184	ENOG4105CBD	Diacylglycerol kinase
Clos_1185	ENOG41067TZ	transcriptional regulator, MarR family
Clos_1186	ENOG4105BZU	Histidine kinase
Clos_1187	ENOG4105C84	Histidine ammonia-lyase
Clos_1188	ENOG4105CI2	imidazolone-5-propionate hydrolase
Clos_1191	ENOG41086WU	UPF0291 protein
Clos_1192	ENOG4108V3W	Chemotaxis protein, CheW
Clos_1196	ENOG4108RCR	degv family
Clos_1197	ENOG4105DUM	transcriptional regulator, lysR family
Clos_1199	ENOG4107V40	secretion protein, HlyD family
Clos_1200	ENOG4105C19	ABC transporter
Clos_1201	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Clos_1203	ENOG4105BZU	Histidine kinase
Clos_1204	ENOG4105EMN	RNA polymerase sigma factor
Clos_1206	ENOG4105C2M	dna polymerase I
Clos_1208	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
Clos_1211	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Clos_1212	ENOG4105DZC	cytosine deaminase
Clos_1217	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Clos_1218	ENOG4105C1J	atp-dependent rna helicase
Clos_1221	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Clos_1223	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Clos_1225	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Clos_1226	ENOG4105CEF	Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)
Clos_1229	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Clos_1230	ENOG4105CSA	Coproporphyrinogen iii oxidase
Clos_1231	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Clos_1232	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Clos_1233	ENOG4105CFG	Acts as a chaperone (By similarity)
Clos_1234	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Clos_1235	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Clos_1236	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Clos_1237	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Clos_1238	ENOG4107YU2	histidine triad (hIT) protein
Clos_1239	ENOG4105VCC	30S ribosomal protein S21
Clos_1240	ENOG4105KTH	gatB Yqey
Clos_1242	ENOG4105DI5	UPF0365 protein
Clos_1244	ENOG41068P3	sporulation protein YqfC
Clos_1246	ENOG4105C9A	Phoh family
Clos_1247	ENOG4105CTJ	Metal Dependent Phosphohydrolase
Clos_1248	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Clos_1249	ENOG4107YR5	Diacylglycerol kinase
Clos_1251	ENOG4105KG3	cytidine deaminase
Clos_1252	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Clos_1253	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
Clos_1254	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Clos_1255	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Clos_1257	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Clos_1258	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Clos_1263	ENOG4105KNA	-acetyltransferase
Clos_1270	ENOG4105VUN	Transcriptional regulator
Clos_1274	ENOG4105VMP	Transcriptional regulator
Clos_1277	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Clos_1278	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Clos_1279	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1282	ENOG4105EGD	dinuclear metal center protein, YbgI family
Clos_1284	ENOG4105VTR	Integrase
Clos_1286	ENOG4107VRI	Transcriptional regulator
Clos_1294	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Clos_1320	ENOG4105W5Q	DNA repair protein (RadC
Clos_1322	ENOG4105D06	uba thif-type nad fad binding protein
Clos_1323	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Clos_1324	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Clos_1327	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Clos_1329	ENOG4105D52	delta-aminolevulinic acid dehydratase
Clos_1330	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Clos_1332	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Clos_1335	ENOG4105DY9	regulatoR
Clos_1336	ENOG4108HRK	Histidine kinase
Clos_1340	ENOG4105P8F	nudix hydrolase
Clos_1343	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Clos_1344	ENOG4105C3U	ABC transporter
Clos_1345	ENOG4108JQ7	(ABC) transporter
Clos_1346	ENOG4108Z7G	MaoC domain protein dehydratase
Clos_1347	ENOG4105DEF	Extracellular solute-binding protein, family 5
Clos_1348	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Clos_1349	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Clos_1350	ENOG4105C3U	ABC transporter
Clos_1351	ENOG4108JQ7	(ABC) transporter
Clos_1352	ENOG4108WBT	adenosyltransferase
Clos_1353	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Clos_1357	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Clos_1358	ENOG4105D49	3-dehydroquinate synthase
Clos_1359	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Clos_1360	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
Clos_1361	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Clos_1364	ENOG4105C3G	gtp-binding protein
Clos_1368	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Clos_1370	ENOG4108V6E	Cell division protein mraZ
Clos_1371	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Clos_1373	ENOG4105CJN	penicillin-binding protein
Clos_1374	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Clos_1375	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Clos_1376	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Clos_1377	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Clos_1378	ENOG4105CNI	cell division protein FtsW
Clos_1379	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Clos_1380	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Clos_1384	ENOG4105K67	small basic protein
Clos_1385	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Clos_1386	ENOG4105FFI	sigma-e processing peptidase spoiiga
Clos_1387	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1388	ENOG4105E65	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1389	ENOG4105WR5	sporulation protein, YlmC YmxH family
Clos_1390	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Clos_1391	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Clos_1392	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Clos_1393	ENOG4105BZU	Histidine kinase
Clos_1399	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Clos_1400	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Clos_1401	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Clos_1402	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
Clos_1404	ENOG4108QD1	Membrane
Clos_1407	ENOG4105DFA	alanine racemase domain protein
Clos_1408	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Clos_1410	ENOG4105DBK	s4 domain protein
Clos_1412	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
Clos_1413	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Clos_1415	ENOG4105NHS	Transcriptional regulator, TraR DksA family
Clos_1416	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Clos_1417	ENOG4105C34	Pseudouridine synthase
Clos_1418	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Clos_1419	ENOG4105F23	Fibronectin-binding protein
Clos_1420	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Clos_1421	ENOG4105DSJ	YicC domain protein
Clos_1422	ENOG4105KC4	UPF0296 protein
Clos_1423	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Clos_1424	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Clos_1425	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Clos_1426	ENOG4105C25	Primosomal protein n'
Clos_1427	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Clos_1428	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Clos_1431	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Clos_1432	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Clos_1433	ENOG4108ZF3	Phosphatase
Clos_1434	ENOG4105D9P	serine threonine protein kinase
Clos_1435	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Clos_1436	ENOG4105DJV	ribulose-phosphate 3-epimerase
Clos_1437	ENOG4105FJ0	thiamine
Clos_1438	ENOG4105VB9	50S ribosomal protein l28
Clos_1439	ENOG4108ZAA	Alkaline-shock protein
Clos_1440	ENOG4105DP4	dak2 domain fusion protein ylov
Clos_1442	ENOG4106H78	methyltransferase
Clos_1443	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Clos_1445	ENOG4105H20	Sporulation integral membrane protein YlbJ
Clos_1446	ENOG4105CDE	UPF0348 protein
Clos_1447	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Clos_1448	ENOG4105KNH	Nucleic acid-binding protein
Clos_1449	ENOG41067VY	50S ribosomal protein L32
Clos_1450	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
Clos_1451	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Clos_1452	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Clos_1453	ENOG4105EA8	2-Nitropropane dioxygenase
Clos_1454	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Clos_1455	ENOG4105CHR	reductase
Clos_1456	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Clos_1457	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Clos_1458	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Clos_1459	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Clos_1460	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Clos_1461	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Clos_1462	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
Clos_1464	ENOG4105K5M	30s ribosomal protein S16
Clos_1465	ENOG4105VB6	UPF0109 protein
Clos_1466	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Clos_1467	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Clos_1468	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Clos_1469	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Clos_1470	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Clos_1471	ENOG4105VFF	UPF0102 protein
Clos_1472	ENOG4105C0P	Mg chelatase subunit ChlI
Clos_1473	ENOG4105C79	DNA protecting protein DprA
Clos_1474	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Clos_1475	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
Clos_1476	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Clos_1477	ENOG4108ZC9	flagellar basal-body rod protein flgc
Clos_1478	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
Clos_1479	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Clos_1480	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Clos_1486	ENOG410822I	Flagellar hook capping protein
Clos_1488	ENOG4105BZE	flagellar hook protein, FlgE
Clos_1490	ENOG4105E14	MotA TolQ exbB proton channel
Clos_1491	ENOG4105ER2	Ompa motb domain protein
Clos_1494	ENOG4105DD5	Flagellar motor switch protein
Clos_1495	ENOG4107YTP	response regulator receiver protein
Clos_1497	ENOG4105CN7	Flagellar biosynthetic protein FliP
Clos_1498	ENOG4105VS8	Flagellar biosynthetic protein fliq
Clos_1499	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Clos_1500	ENOG4105D00	flagellar biosynthetic protein flhB
Clos_1501	ENOG4105D7B	Flagellar biosynthesis protein flha
Clos_1502	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Clos_1504	ENOG4108T7K	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity)
Clos_1505	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Clos_1506	ENOG4105CBS	Chea signal transduction histidine kinase
Clos_1507	ENOG4108V3W	Chemotaxis protein, CheW
Clos_1509	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
Clos_1510	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1513	ENOG4105CE9	30S ribosomal protein S2
Clos_1514	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Clos_1515	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Clos_1516	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Clos_1517	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Clos_1518	ENOG4105KNE	Phosphatidate cytidylyltransferase
Clos_1519	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Clos_1520	ENOG4105DZP	Membrane-associated zinc metalloprotease
Clos_1522	ENOG4105CKK	Glycosyl transferase, family 2
Clos_1523	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Clos_1524	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Clos_1525	ENOG4105CHV	Transcription elongation factor NusA
Clos_1526	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
Clos_1528	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Clos_1529	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Clos_1530	ENOG4105SFS	phosphoesterase RecJ domain protein
Clos_1531	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Clos_1532	ENOG4105DTN	riboflavin biosynthesis protein ribF
Clos_1533	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Clos_1534	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Clos_1536	ENOG4105C1V	Peptidase, M16
Clos_1538	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
Clos_1539	ENOG4105CNU	cell division protein FtsK
Clos_1540	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Clos_1541	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Clos_1543	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Clos_1544	ENOG4105MCT	stage V sporulation protein S
Clos_1545	ENOG4105DB7	PHP domain protein
Clos_1548	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Clos_1549	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Clos_1550	ENOG4105CXI	aluminum resistance protein
Clos_1551	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Clos_1552	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Clos_1553	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Clos_1554	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Clos_1555	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Clos_1557	ENOG4105CN9	Peptidase m42 family protein
Clos_1558	ENOG4105CN9	Peptidase m42 family protein
Clos_1559	ENOG4105CN9	Peptidase m42 family protein
Clos_1560	ENOG4105BZU	Histidine kinase
Clos_1561	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Clos_1562	ENOG4108IUH	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Clos_1563	ENOG4105F6E	Acyl-transferase
Clos_1564	ENOG4105CAT	Cytidine monophosphate kinase
Clos_1565	ENOG4105KHN	chorismate mutase
Clos_1566	ENOG4105CBX	hi0933 family
Clos_1567	ENOG4105CVJ	phosphoglycerate mutase
Clos_1568	ENOG4105QEK	Transcriptional regulator
Clos_1570	ENOG4105DQU	oxidoreductase, subunit beta
Clos_1571	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Clos_1574	ENOG4107QSA	Oxaloacetate decarboxylase
Clos_1577	ENOG4105FE9	pseudouridine synthase
Clos_1578	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Clos_1580	ENOG4105DZ1	carboxypeptidase
Clos_1582	ENOG4105KBJ	sporulation protein ytfj
Clos_1585	ENOG4105CYW	agmatinase
Clos_1586	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Clos_1587	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Clos_1588	ENOG4105DZ1	carboxypeptidase
Clos_1590	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Clos_1592	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
Clos_1593	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Clos_1598	ENOG4105CKK	Glycosyl transferase, family 2
Clos_1601	ENOG410691R	Modulates RecA activity (By similarity)
Clos_1602	ENOG4107QQR	Sporulation
Clos_1603	ENOG4105S1Z	Stage IV sporulation protein B
Clos_1604	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Clos_1605	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Clos_1606	ENOG4105DX0	Hemolysin A
Clos_1607	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Clos_1609	ENOG4105CTB	Polyprenyl synthetase
Clos_1610	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Clos_1611	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Clos_1613	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Clos_1614	ENOG4108ZSR	alkaline shock protein
Clos_1619	ENOG4105KQ4	Stage iii sporulation protein ad
Clos_1620	ENOG4108CQH	stage III sporulation protein AC
Clos_1622	ENOG4105CD2	stage iii sporulation protein aa
Clos_1624	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Clos_1625	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Clos_1630	ENOG4105RYY	domain protein
Clos_1634	ENOG4106A3R	peptidase
Clos_1637	ENOG4105CZX	twitching motility protein
Clos_1638	ENOG4107QHF	type ii secretion system protein e
Clos_1639	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
Clos_1641	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1653	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1654	ENOG4105CJN	penicillin-binding protein
Clos_1655	ENOG4105DBI	uridine monophosphokinase
Clos_1656	ENOG4105CFP	Peptidase U32
Clos_1657	ENOG4108VQJ	O-methyltransferase
Clos_1660	ENOG4105CN5	Metallo-Beta-Lactamase
Clos_1661	ENOG4105I3K	Ferric uptake regulator, Fur family
Clos_1662	ENOG41068XD	UPF0473 protein
Clos_1663	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Clos_1665	ENOG4105VBH	UPF0297 protein
Clos_1666	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Clos_1669	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
Clos_1672	ENOG4105K4I	Scp-like extracellular
Clos_1676	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Clos_1678	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Clos_1683	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Clos_1688	ENOG4105D1H	recombination factor protein RarA
Clos_1693	ENOG4106M28	alanine racemase domain protein
Clos_1695	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
Clos_1696	ENOG4105KIJ	D-ornithine aminomutase S component
Clos_1697	ENOG4107RH1	pyridoxal-5'-phosphate-dependent protein beta subunit
Clos_1698	ENOG4105Z5Q	
Clos_1699	ENOG4108KR4	dihydrodipicolinate reductase
Clos_1700	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Clos_1704	ENOG4105DFM	M18 family aminopeptidase
Clos_1707	ENOG4105CUZ	uba thif-type nad fad binding protein
Clos_1709	ENOG4105C9M	aspartyl-trna synthetase
Clos_1710	ENOG4105CUT	histidyl-tRNA synthetase
Clos_1711	ENOG4105D4P	Coproporphyrinogen iii oxidase
Clos_1712	ENOG4107VMB	Beta-lactamase domain protein
Clos_1713	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Clos_1714	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Clos_1715	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Clos_1716	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Clos_1717	ENOG4108Z0R	Transferase
Clos_1718	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Clos_1721	ENOG4105VIE	preprotein translocase, subunit YajC
Clos_1724	ENOG4105JFG	SpoIID LytB domain protein
Clos_1725	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Clos_1726	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Clos_1727	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Clos_1728	ENOG4105DAN	ATP-dependent protease
Clos_1730	ENOG4105VKD	bioY protein
Clos_1731	ENOG4105FE9	pseudouridine synthase
Clos_1733	ENOG4105BZU	Histidine kinase
Clos_1734	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_1735	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Clos_1736	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
Clos_1737	ENOG4105BZG	amino acid carrier protein
Clos_1739	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
Clos_1740	ENOG4105DZ1	carboxypeptidase
Clos_1741	ENOG4105EJQ	L-serine dehydratase
Clos_1743	ENOG4105KME	endoribonuclease L-psp
Clos_1745	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Clos_1747	ENOG4108WF2	Metal Dependent Phosphohydrolase
Clos_1748	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Clos_1750	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Clos_1751	ENOG4105K46	50S ribosomal protein l27
Clos_1753	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Clos_1754	ENOG4105C03	ribonuclease
Clos_1759	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Clos_1760	ENOG4107QMS	site-determining protein
Clos_1761	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Clos_1762	ENOG4105CJN	penicillin-binding protein
Clos_1765	ENOG4105DFF	Rod shape-determining protein mreb
Clos_1766	ENOG4105W5Q	DNA repair protein (RadC
Clos_1767	ENOG4108Z03	MAF-like protein
Clos_1770	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Clos_1771	ENOG4105DGN	Electron transport complex
Clos_1772	ENOG4105DZB	Electron transport complex
Clos_1773	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
Clos_1774	ENOG4105D6A	Electron transport complex
Clos_1775	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Clos_1777	ENOG4105K4H	Nlp p60 protein
Clos_1778	ENOG4105CDY	transcriptional regulatory protein
Clos_1779	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
Clos_1783	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Clos_1786	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Clos_1791	ENOG41090VF	Stage v sporulation protein ac
Clos_1794	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_1796	ENOG41082AN	stage II sporulation protein
Clos_1797	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Clos_1798	ENOG4108UAU	isochorismatase
Clos_1805	ENOG4105D4T	Citrate transporter
Clos_1806	ENOG4108JUB	Transcriptional regulator
Clos_1808	ENOG4105UQX	Mate efflux family protein
Clos_1809	ENOG4105K5X	acetyltransferase
Clos_1811	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Clos_1812	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Clos_1813	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Clos_1814	ENOG4107QI6	Cysteine desulfurase
Clos_1816	ENOG4105HDK	L-asparaginase
Clos_1817	ENOG4105ENA	helicase
Clos_1821	ENOG4108IMY	Transcriptional regulator
Clos_1828	ENOG4107RE7	phosphate butyryltransferase
Clos_1831	ENOG4107G43	radical SAM domain protein
Clos_1835	ENOG4105EWC	Purine nucleoside phosphorylase
Clos_1836	ENOG4105C98	muts2 protein
Clos_1837	ENOG4105CI3	gtp-binding protein typa
Clos_1838	ENOG4105DZ0	fad dependent oxidoreductase
Clos_1839	ENOG4105CBX	hi0933 family
Clos_1840	ENOG4108RAC	Rubrerythrin
Clos_1842	ENOG4105HKU	nucleoside recognition domain-containing protein
Clos_1843	ENOG4105HKU	nucleoside recognition domain-containing protein
Clos_1853	ENOG41067QW	Transcriptional regulator
Clos_1856	ENOG4108PPJ	Type II restriction
Clos_1890	ENOG410756H	nucleotidyltransferase
Clos_1893	ENOG4105DQ6	Transposase
Clos_1894	ENOG41090WB	Transposase is3 is911
Clos_1923	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
Clos_1924	ENOG4107QJE	Chromosome Partitioning Protein
Clos_1936	ENOG4105D7N	magnesium and cobalt transport protein CorA
Clos_1937	ENOG4107S9D	Alpha beta hydrolase
Clos_1938	ENOG4105E0Y	RtcB Protein
Clos_1939	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Clos_1940	ENOG4105EXW	epimerase dehydratase
Clos_1943	ENOG4105CEV	competence damage-inducible protein
Clos_1945	ENOG4105BZ1	(ABC) transporter
Clos_1946	ENOG4105BZ1	(ABC) transporter
Clos_1949	ENOG4105BZU	Histidine kinase
Clos_1950	ENOG4105CNW	domain protein
Clos_1951	ENOG4105C2W	permease
Clos_1954	ENOG4105D98	threonine synthase
Clos_1955	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Clos_1956	ENOG41090I5	UPF0735 ACT domain-containing protein
Clos_1957	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Clos_1960	ENOG4107R88	Chemotaxis protein (CheV)
Clos_1965	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Clos_1967	ENOG4108VPT	UPF0234 protein
Clos_1969	ENOG4105CFP	Peptidase U32
Clos_1970	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
Clos_1971	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Clos_1972	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Clos_1973	ENOG4108RWN	rrna methyltransferase
Clos_1974	ENOG4107ZYR	domain protein
Clos_1975	ENOG4105CZN	Potassium uptake protein
Clos_1976	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Clos_1977	ENOG4105VJV	50s ribosomal protein L35
Clos_1978	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Clos_1980	ENOG4105C22	threonyL-tRNA synthetase
Clos_1981	ENOG4108UH6	UPF0754 membrane protein
Clos_1984	ENOG4105CE1	Ferrous iron transport protein b
Clos_1985	ENOG4105EKQ	RNA-directed DNA polymerase
Clos_1986	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Clos_1987	ENOG4105DQ6	Transposase
Clos_1988	ENOG41090WB	Transposase is3 is911
Clos_1998	ENOG4105X5K	response regulator receiver protein
Clos_2000	ENOG41090WB	Transposase is3 is911
Clos_2001	ENOG4105DQ6	Transposase
Clos_2003	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Clos_2006	ENOG4108D32	Methyltransferase
Clos_2008	ENOG4105CSV	Glutaminase
Clos_2009	ENOG4105C22	threonyL-tRNA synthetase
Clos_2010	ENOG41080XP	Cbs domain
Clos_2011	ENOG4105C3F	Signal peptidase i
Clos_2013	ENOG4108PNU	Involved in the degradation of specific anti-sigma factors (By similarity)
Clos_2015	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Clos_2017	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Clos_2018	ENOG4108ZJ4	polysaccharide deacetylase
Clos_2021	ENOG4108IJ7	Glycine betaine
Clos_2022	ENOG4107HG4	Transcriptional regulator
Clos_2023	ENOG4105CHM	Aminotransferase
Clos_2028	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Clos_2033	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Clos_2034	ENOG4105CFG	Acts as a chaperone (By similarity)
Clos_2038	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Clos_2039	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Clos_2041	ENOG4105D2X	ABC transporter substrate-binding protein
Clos_2047	ENOG4105IJJ	transcriptional regulator, crp fnr family
Clos_2049	ENOG410681U	heavy metal transport detoxification protein
Clos_2050	ENOG4105CEM	UPF0597 protein
Clos_2051	ENOG4108JUB	Transcriptional regulator
Clos_2054	ENOG4105JAB	phenazine biosynthesis protein, phzf family
Clos_2056	ENOG4105E0X	reductase
Clos_2066	ENOG4105C5H	ABC transporter
Clos_2068	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Clos_2073	ENOG4105CJW	magnesium transporter
Clos_2074	ENOG4105CNI	cell division protein FtsW
Clos_2075	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2081	ENOG4108HVR	ABC transporter, permease
Clos_2084	ENOG4105CJZ	response regulator
Clos_2085	ENOG4105CBJ	Metal-dependent enzyme
Clos_2088	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Clos_2094	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
Clos_2095	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Clos_2099	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Clos_2101	ENOG4107EFR	Flavocytochrome c
Clos_2102	ENOG4107EFR	Flavocytochrome c
Clos_2103	ENOG41088B0	Major membrane immunogen
Clos_2104	ENOG4105CJ2	(LipO)protein
Clos_2107	ENOG4105DDG	Cyanophycinase
Clos_2108	ENOG4108ZJ4	polysaccharide deacetylase
Clos_2109	ENOG4105EAM	Na Pi-cotransporter
Clos_2110	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Clos_2113	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Clos_2114	ENOG4105QNR	S1 RNA binding domain protein
Clos_2118	ENOG4105EPR	degv family
Clos_2120	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Clos_2123	ENOG4105C31	Tryptophanyl-tRNA synthetase
Clos_2124	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Clos_2125	ENOG4105DQU	oxidoreductase, subunit beta
Clos_2127	ENOG4105CKU	formyltetrahydrofolate synthetase
Clos_2128	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2132	ENOG4105IJJ	transcriptional regulator, crp fnr family
Clos_2134	ENOG4105FAV	ABC, transporter
Clos_2135	ENOG4105FDK	ABC transporter
Clos_2136	ENOG4105DSE	periplasmic solute binding protein
Clos_2137	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Clos_2139	ENOG4105CBC	glutamate synthase
Clos_2140	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Clos_2141	ENOG4108PU5	4fe-4S ferredoxin, iron-sulfur binding domain protein
Clos_2142	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Clos_2143	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Clos_2144	ENOG4108PU5	4fe-4S ferredoxin, iron-sulfur binding domain protein
Clos_2146	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Clos_2148	ENOG4105CIZ	coA-substrate-specific enzyme activase
Clos_2149	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
Clos_2150	ENOG4105CIZ	coA-substrate-specific enzyme activase
Clos_2153	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Clos_2154	ENOG4105BZU	Histidine kinase
Clos_2155	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Clos_2157	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Clos_2158	ENOG4108JQ7	(ABC) transporter
Clos_2159	ENOG4105C3U	ABC transporter
Clos_2160	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Clos_2161	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Clos_2162	ENOG4105C59	p-type ATPase
Clos_2165	ENOG4105EB3	Histidine kinase
Clos_2166	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_2168	ENOG4105VCQ	rubredoxin
Clos_2170	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Clos_2171	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Clos_2172	ENOG4108IUQ	atp-dependent protease
Clos_2173	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Clos_2174	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Clos_2175	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Clos_2176	ENOG4105VEQ	Cold shock protein
Clos_2178	ENOG41090K0	Transcriptional regulator, Crp Fnr family
Clos_2179	ENOG4105CNW	domain protein
Clos_2181	ENOG4105C5B	carbamate kinase
Clos_2183	ENOG4105DU6	RNA polymerase
Clos_2185	ENOG4108UIN	ybak prolyl-trna synthetase associated region
Clos_2188	ENOG4105CXT	aspartate transcarbamylase
Clos_2190	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Clos_2191	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Clos_2192	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Clos_2193	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
Clos_2194	ENOG4105CD3	dihydroorotase
Clos_2196	ENOG4108QY0	Membrane
Clos_2197	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Clos_2199	ENOG4105BZU	Histidine kinase
Clos_2203	ENOG4108JIC	nucleoside recognition domain protein
Clos_2204	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2208	ENOG4108TGR	phosphatase
Clos_2209	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Clos_2210	ENOG4108YZT	Adenosylcobinamide kinase
Clos_2211	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Clos_2212	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Clos_2213	ENOG4105EQN	UPF0261 protein
Clos_2217	ENOG4105ENY	Ethanolamine utilization protein eutH
Clos_2219	ENOG4108Z29	Flavodoxin
Clos_2223	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Clos_2224	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
Clos_2227	ENOG4107S17	Phosphate-binding protein
Clos_2232	ENOG4105DQ6	Transposase
Clos_2233	ENOG41090WB	Transposase is3 is911
Clos_2246	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Clos_2247	ENOG4107Y7X	LytTR
Clos_2250	ENOG4108IEH	NADH dehydrogenase subunit g
Clos_2251	ENOG4107QIZ	NADH dehydrogenase
Clos_2252	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
Clos_2255	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Clos_2257	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Clos_2258	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Clos_2259	ENOG4105CN1	protease
Clos_2260	ENOG41063SB	peptidase
Clos_2261	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Clos_2262	ENOG4105CAK	Cell division ATP-binding protein ftsE
Clos_2263	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Clos_2266	ENOG4108IUS	Transketolase
Clos_2267	ENOG4108HHA	Transketolase
Clos_2268	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
Clos_2273	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
Clos_2275	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Clos_2276	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Clos_2281	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
Clos_2282	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Clos_2283	ENOG4105E0C	molybdate abc transporter
Clos_2284	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Clos_2287	ENOG4107R7I	amino acid
Clos_2288	ENOG4105EYH	Exonuclease
Clos_2290	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Clos_2291	ENOG4105CEN	a g-specific adenine glycosylase
Clos_2299	ENOG4105C5H	ABC transporter
Clos_2300	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Clos_2302	ENOG4105DPH	UPF0371 protein
Clos_2303	ENOG4105HMI	Membrane
Clos_2304	ENOG4105CHM	Aminotransferase
Clos_2305	ENOG4105DWD	nucleoside recognition domain protein
Clos_2306	ENOG4105DCT	glycerol dehydrogenase
Clos_2307	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Clos_2309	ENOG4108Z4T	Peptidase M50
Clos_2310	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Clos_2312	ENOG4105E1K	spore germination protein
Clos_2314	ENOG4105DER	m42 family
Clos_2317	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Clos_2318	ENOG4105CGK	Exodeoxyribonuclease III
Clos_2321	ENOG41086D8	Transcriptional regulator
Clos_2328	ENOG4105CTK	cobaltochelatase, cobn subunit
Clos_2329	ENOG4105DQ5	transport system permease protein
Clos_2330	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Clos_2331	ENOG4108RAC	Rubrerythrin
Clos_2332	ENOG4105DJ4	phosphatidylserine decarboxylase
Clos_2337	ENOG4105FF2	Type I DHQase
Clos_2340	ENOG4105C1J	atp-dependent rna helicase
Clos_2341	ENOG4105C5S	asparaginyl-tRNA synthetase
Clos_2342	ENOG4105C5Q	Transcriptional regulator
Clos_2344	ENOG4107QJT	sodium dicarboxylate symporter
Clos_2346	ENOG4108ZJ4	polysaccharide deacetylase
Clos_2348	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Clos_2353	ENOG4107Y80	Major Facilitator superfamily
Clos_2355	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
Clos_2359	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
Clos_2361	ENOG4107QP7	CoA-transferase subunit A
Clos_2362	ENOG4108JUB	Transcriptional regulator
Clos_2363	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
Clos_2364	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Clos_2365	ENOG4105CRE	cytochrome C
Clos_2367	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Clos_2368	ENOG4108ZQX	ybak prolyl-trna synthetase
Clos_2370	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_2371	ENOG4105CY0	Metallo-Beta-Lactamase
Clos_2372	ENOG4108REF	Sporulation integral membrane protein ytvi
Clos_2373	ENOG4105D17	glycoside hydrolase, family 3 domain protein
Clos_2375	ENOG4108I5U	Uridine phosphorylase
Clos_2378	ENOG4105UIB	(ABC) transporter
Clos_2379	ENOG4108JQ9	ABC transporter
Clos_2380	ENOG4105DIH	basic membrane
Clos_2382	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Clos_2384	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2385	ENOG4105KNY	Microcompartments protein
Clos_2386	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
Clos_2387	ENOG4108EKI	Dehydrogenase
Clos_2388	ENOG4105KNY	Microcompartments protein
Clos_2389	ENOG4105NDK	ethanolamine utilization protein
Clos_2391	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Clos_2393	ENOG4107RWI	ethanolamine utilization protein eutJ
Clos_2395	ENOG4105KTW	ethanolamine utilization protein
Clos_2396	ENOG4105M3W	utilization protein
Clos_2397	ENOG4105F1A	Pyruvate formate-lyase
Clos_2398	ENOG4105C6N	Formate acetyltransferase
Clos_2399	ENOG4108EKI	Dehydrogenase
Clos_2400	ENOG4105KNY	Microcompartments protein
Clos_2401	ENOG4105KNY	Microcompartments protein
Clos_2404	ENOG4108KN0	Choline kinase
Clos_2405	ENOG4108EKI	Dehydrogenase
Clos_2406	ENOG4108HRK	Histidine kinase
Clos_2407	ENOG4107XVH	Transcriptional regulator
Clos_2413	ENOG4105CKM	Branched-chain carboxylic acid kinase
Clos_2414	ENOG4107RE7	phosphate butyryltransferase
Clos_2415	ENOG4108JUB	Transcriptional regulator
Clos_2417	ENOG4105C8B	TIGR00159 family
Clos_2419	ENOG4105C8Y	Acetylornithine aminotransferase
Clos_2422	ENOG4105VW4	glutaredoxin 3
Clos_2424	ENOG4108QG2	Membrane
Clos_2425	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
Clos_2426	ENOG4108JU6	CBS domain protein
Clos_2427	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
Clos_2428	ENOG4105E0A	ABC, transporter
Clos_2429	ENOG4105TVJ	transport system, permease
Clos_2430	ENOG4105DQ5	transport system permease protein
Clos_2433	ENOG410841Q	phosphoesterase PA-phosphatase related protein
Clos_2435	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Clos_2442	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
Clos_2443	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
Clos_2444	ENOG4105CHU	acetyl-coa acetyltransferase
Clos_2445	ENOG4108JUB	Transcriptional regulator
Clos_2446	ENOG4106JUT	Streptomycin 3''-adenylyltransferase
Clos_2447	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Clos_2448	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Clos_2454	ENOG4105CJ1	ABC, transporter
Clos_2455	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Clos_2456	ENOG4105ETE	Transcriptional regulator (LacI family
Clos_2457	ENOG4105DZC	cytosine deaminase
Clos_2458	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
Clos_2459	ENOG4105D82	Glutamate dehydrogenase
Clos_2461	ENOG41084EF	Ferredoxin
Clos_2464	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Clos_2465	ENOG4105C5H	ABC transporter
Clos_2467	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Clos_2468	ENOG410801F	ribosomal-protein-alanine acetyltransferase
Clos_2469	ENOG41072GX	Peptidase M22 Glycoprotease
Clos_2470	ENOG4105K8N	protein family UPF0079, ATPase
Clos_2472	ENOG4105EQD	regulatoR
Clos_2473	ENOG4105BZU	Histidine kinase
Clos_2474	ENOG4108SAX	Membrane
Clos_2476	ENOG4105CI2	imidazolone-5-propionate hydrolase
Clos_2480	ENOG4105VM1	flagellar
Clos_2483	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2484	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Clos_2485	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Clos_2487	ENOG4105MS2	ribosomal subunit Interface protein
Clos_2489	ENOG4105MQ3	flagellar protein FliS
Clos_2490	ENOG4107RT6	flagellar hook-associated
Clos_2493	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Clos_2494	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Clos_2495	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
Clos_2496	ENOG4108JUB	Transcriptional regulator
Clos_2497	ENOG4105DFD	Na H antiporter
Clos_2498	ENOG4108IV0	ABC, transporter
Clos_2499	ENOG4105C0Z	ABC transporter
Clos_2500	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Clos_2501	ENOG4105C32	Amino acid ABC transporter (Permease)
Clos_2513	ENOG4107TY6	Acylneuraminate cytidylyltransferase
Clos_2514	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Clos_2515	ENOG4105C5E	polysaccharide biosynthesis protein
Clos_2518	ENOG4105I03	Flagellin
Clos_2519	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2521	ENOG4105E1Q	flagellar hook-associated protein
Clos_2524	ENOG4105RU3	
Clos_2525	ENOG4105MJ2	Competence protein
Clos_2526	ENOG4105C7H	Helicase, RecD TraA family
Clos_2530	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Clos_2531	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Clos_2534	ENOG41085AS	UPF0473 protein
Clos_2535	ENOG4105BZU	Histidine kinase
Clos_2536	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Clos_2537	ENOG4107RUE	extracellular solute-binding protein family 1
Clos_2538	ENOG4105D38	putrescine abc transporter
Clos_2539	ENOG4105F38	ABC transporter, permease
Clos_2540	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Clos_2542	ENOG4105KT7	mgtC SapB transporter
Clos_2543	ENOG4105C6Z	Gluconate
Clos_2545	ENOG4105G63	Type III effector Hrp-dependent
Clos_2546	ENOG4105MVE	transcriptional regulator
Clos_2547	ENOG4105VRS	hydrolase family 18
Clos_2548	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
Clos_2549	ENOG4105CGA	flagellar basal-body rod protein FlgG
Clos_2550	ENOG4105CGA	flagellar basal-body rod protein FlgG
Clos_2552	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
Clos_2555	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Clos_2559	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Clos_2560	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Clos_2561	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Clos_2562	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Clos_2563	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Clos_2564	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Clos_2565	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Clos_2569	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Clos_2570	ENOG4105ESV	Glycosyl transferase, family 4
Clos_2571	ENOG4108UK2	deaminase
Clos_2572	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Clos_2573	ENOG4108YZG	isomerase
Clos_2574	ENOG4107WAU	Protein tyrosine phosphatase
Clos_2575	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Clos_2576	ENOG4105CJN	penicillin-binding protein
Clos_2578	ENOG4105HZM	Fha domain containing protein
Clos_2579	ENOG41081FK	Mediates zinc uptake. May also transport other divalent cations (By similarity)
Clos_2580	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Clos_2581	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Clos_2582	ENOG4105CBJ	Metal-dependent enzyme
Clos_2583	ENOG4108KYE	ABC-2 type transporter
Clos_2585	ENOG4105CJ1	ABC, transporter
Clos_2587	ENOG4105C8T	Leucyl-tRNA synthetase
Clos_2589	ENOG4107104	thymidine kinase
Clos_2590	ENOG41082DI	50s ribosomal protein l31
Clos_2591	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Clos_2592	ENOG4105CDA	abc transporter atp-binding protein
Clos_2593	ENOG4105E5Q	amino acid AbC transporter
Clos_2594	ENOG4105E89	ABC transporter
Clos_2595	ENOG4105CBT	Fructose-1,6-bisphosphatase
Clos_2596	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Clos_2597	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
Clos_2598	ENOG4108UYI	beta-alanyl-CoA ammonia lyase
Clos_2599	ENOG4105C8J	)-transporter
Clos_2600	ENOG4105C8J	)-transporter
Clos_2601	ENOG4108SHJ	s-layer protein
Clos_2602	ENOG4105T09	s-layer domain-containing protein
Clos_2609	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Clos_2612	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Clos_2614	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Clos_2616	ENOG4105C19	ABC transporter
Clos_2619	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Clos_2620	ENOG4108IG5	Transcriptional regulator
Clos_2623	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Clos_2628	ENOG4105T09	s-layer domain-containing protein
Clos_2630	ENOG4105C9X	ppx gppa phosphatase
Clos_2631	ENOG41060GV	RNA binding s1 domain protein
Clos_2634	ENOG4105VYY	sporulation protein yabp
Clos_2636	ENOG41082I2	s4 domain protein
Clos_2637	ENOG4105K70	DNA-binding protein
Clos_2638	ENOG4108IY2	MazG family
Clos_2640	ENOG4108M14	stage v sporulation protein t
Clos_2641	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Clos_2642	ENOG4108JA2	transcriptioN-repair coupling factor
Clos_2644	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Clos_2645	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Clos_2646	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Clos_2647	ENOG4105K4W	Could be involved in septation (By similarity)
Clos_2648	ENOG4105DFT	pur operon repressor
Clos_2649	ENOG4105DFU	Cell wall formation (By similarity)
Clos_2650	ENOG4108KGH	TRANSCRIPTIONal
Clos_2653	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Clos_2654	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
Clos_2655	ENOG4105CFC	Transporter
Clos_2657	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Clos_2658	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
Clos_2659	ENOG41069ER	domain protein
Clos_2660	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Clos_2661	ENOG4105F8V	Hydrolase, tatD family
Clos_2662	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Clos_2665	ENOG4108JIC	nucleoside recognition domain protein
Clos_2666	ENOG4105DAP	Nicotinate phosphoribosyltransferase
Clos_2667	ENOG4105KRN	Transcriptional regulator, abrb family
Clos_2668	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Clos_2669	ENOG41060K3	Methyltransferase
Clos_2673	ENOG4108WZW	RNA polymerase sigma
Clos_2677	ENOG4105BZ1	(ABC) transporter
Clos_2680	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Clos_2681	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Clos_2685	ENOG4105EAB	amino acid AbC transporter
Clos_2688	ENOG4105C6N	Formate acetyltransferase
Clos_2689	ENOG4105DRR	Transcriptional regulator, GntR family
Clos_2690	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Clos_2693	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Clos_2694	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
Clos_2696	ENOG4105CHR	reductase
Clos_2697	ENOG4107T2D	Phosphoribosylaminoimidazolesuccinocarboxamide synthase
Clos_2699	ENOG4105C98	muts2 protein
Clos_2703	ENOG4105C7J	ABC transporter, permease
Clos_2706	ENOG4105SX7	Transporter
Clos_2708	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Clos_2709	ENOG4107XJU	UPF0178 protein
Clos_2710	ENOG4107EFR	Flavocytochrome c
Clos_2711	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Clos_2712	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Clos_2716	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Clos_2717	ENOG4107QIV	Cytochrome c biogenesis protein
Clos_2718	ENOG4105E1K	spore germination protein
Clos_2724	ENOG4105WD1	Membrane
Clos_2728	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Clos_2729	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Clos_2733	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
Clos_2734	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
Clos_2737	ENOG4108UYE	Lactoylglutathione lyase
Clos_2739	ENOG4105DFD	Na H antiporter
Clos_2740	ENOG4105C75	arginyL-tRNA synthetase
Clos_2741	ENOG4105PAD	Hydrolase
Clos_2742	ENOG4105BZG	amino acid carrier protein
Clos_2744	ENOG4105HFT	AraC family transcriptional regulator
Clos_2745	ENOG41086D8	Transcriptional regulator
Clos_2747	ENOG4108RNG	Permease of the drug metabolite transporter
Clos_2748	ENOG41075H3	AraC family transcriptional regulator
Clos_2749	ENOG4108RCM	Nitroreductase
Clos_2751	ENOG4105CJ1	ABC, transporter
Clos_2752	ENOG4107TXC	Transcriptional regulator
Clos_2758	ENOG4105EPR	degv family
Clos_2759	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Clos_2761	ENOG4105MEW	serine threonine protein phosphatase
Clos_2762	ENOG4105DDN	Pentapeptide repeat-containing protein
Clos_2765	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
Clos_2771	ENOG4105CD3	dihydroorotase
Clos_2774	ENOG4107TTQ	Alpha beta hydrolase fold
Clos_2775	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Clos_2777	ENOG4105C0H	protease
Clos_2778	ENOG4105Q2H	domain protein
Clos_2783	ENOG4105BZU	Histidine kinase
Clos_2784	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Clos_2786	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Clos_2787	ENOG4105D58	Diguanylate phosphodiesterase
Clos_2788	ENOG4105BZU	Histidine kinase
Clos_2789	ENOG4105C8Q	Methyl-accepting chemotaxis
Clos_2790	ENOG4108NEV	two component transcriptional regulator, LytTR family
Clos_2792	ENOG4108K5P	(LipO)protein
Clos_2797	ENOG4105CDU	Replicative dna helicase
Clos_2798	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Clos_2799	ENOG4105BZR	domain protein
Clos_2804	ENOG4108IAB	Phoh family
Clos_2805	ENOG410828M	hemerythrin-like, metal-binding protein
Clos_2806	ENOG4108RAC	Rubrerythrin
Clos_2807	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Clos_2808	ENOG4107XVH	Transcriptional regulator
Clos_2809	ENOG4108SA1	esterase
Clos_2810	ENOG4105E0A	ABC, transporter
Clos_2816	ENOG4107VMI	polysaccharide deacetylase
Clos_2823	ENOG4107RH1	pyridoxal-5'-phosphate-dependent protein beta subunit
Clos_2824	ENOG4105Z5Q	
Clos_2826	ENOG4105BZU	Histidine kinase
Clos_2836	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Clos_2844	ENOG4108W0I	acetyltransferase
Clos_2846	ENOG41086D8	Transcriptional regulator
Clos_2854	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Clos_2855	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Clos_2856	ENOG4105C6E	dna polymerase iii
Clos_2858	ENOG4108ZDA	Sporulation protein YyaC
Clos_2860	ENOG4105CPF	Cell wall formation (By similarity)
Clos_2861	ENOG4107RBI	VanW family
Clos_2866	ENOG4105C9B	Cysteine desulfurase
Clos_2867	ENOG4105FA0	parb-like partition protein
Clos_2868	ENOG4107QJE	Chromosome Partitioning Protein
Clos_2870	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Clos_2871	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Clos_2872	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Clos_2873	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
Clos_2874	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Clos_2875	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Clos_2876	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Clos_2877	ENOG4105VG0	50S ribosomal protein l34