locus-tag	class	description
Clos_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Clos_0002	COG0592	DNA-directed DNA polymerase activity
Clos_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Clos_0006	COG0187	DNA topoisomerase II activity
Clos_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Clos_0008	COG1366	Belongs to the anti-sigma-factor antagonist family
Clos_0009	COG2172	sigma factor antagonist activity
Clos_0010	COG1191	sigma factor activity
Clos_0011	COG1827	regulation of RNA biosynthetic process
Clos_0014	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Clos_0018	COG0590	tRNA wobble adenosine to inosine editing
Clos_0019	COG0095	Lipoate-protein ligase
Clos_0022	COG0425	Belongs to the sulfur carrier protein TusA family
Clos_0025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Clos_0026	COG3290	protein histidine kinase activity
Clos_0026	COG3829	transcription factor binding
Clos_0027	COG4656	Part of a membrane complex involved in electron transport
Clos_0028	COG0252	asparaginase activity
Clos_0028	COG5275	peptidyl-tyrosine sulfation
Clos_0031	COG5275	peptidyl-tyrosine sulfation
Clos_0031	COG0252	asparaginase activity
Clos_0032	COG5275	peptidyl-tyrosine sulfation
Clos_0032	COG0252	asparaginase activity
Clos_0035	COG0360	Binds together with S18 to 16S ribosomal RNA
Clos_0037	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Clos_0042	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Clos_0044	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Clos_0045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Clos_0052	COG0840	transmembrane signaling receptor activity
Clos_0053	COG1937	Protein conserved in bacteria
Clos_0054	COG2217	Heavy metal translocating P-type atpase
Clos_0056	COG1917	Cupin 2, conserved barrel domain protein
Clos_0056	COG4977	sequence-specific DNA binding
Clos_0057	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Clos_0059	COG1982	Orn Lys Arg decarboxylase major
Clos_0060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Clos_0061	COG3870	Protein conserved in bacteria
Clos_0063	COG1774	PSP1 C-terminal conserved region
Clos_0064	COG0493	'glutamate synthase
Clos_0065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Clos_0066	COG0509	glycine decarboxylation via glycine cleavage system
Clos_0067	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Clos_0068	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Clos_0072	COG3426	butyrate kinase activity
Clos_0073	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Clos_0075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Clos_0078	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Clos_0080	COG1410	methionine synthase
Clos_0080	COG0646	methionine synthase
Clos_0082	COG1695	Transcriptional regulator
Clos_0085	COG3829	transcription factor binding
Clos_0085	COG3290	protein histidine kinase activity
Clos_0087	COG2610	gluconate transmembrane transporter activity
Clos_0088	COG1250	3-hydroxyacyl-CoA dehydrogenase
Clos_0089	COG1028	Short-chain dehydrogenase reductase Sdr
Clos_0090	COG2030	dehydratase
Clos_0091	COG1960	acyl-CoA dehydrogenase activity
Clos_0092	COG2086	electron transfer activity
Clos_0093	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Clos_0095	COG0745	RESPONSE REGULATOR receiver
Clos_0096	COG5002	protein histidine kinase activity
Clos_0101	COG0488	(ABC) transporter
Clos_0108	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Clos_0113	COG3340	Belongs to the peptidase S51 family
Clos_0120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Clos_0121	COG0745	RESPONSE REGULATOR receiver
Clos_0124	COG2205	protein histidine kinase activity
Clos_0125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Clos_0126	COG2011	ABC-type metal ion transport system permease component
Clos_0127	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Clos_0128	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Clos_0129	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Clos_0137	COG0542	response to heat
Clos_0141	COG1136	(ABC) transporter
Clos_0142	COG0577	efflux transmembrane transporter activity
Clos_0145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Clos_0148	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Clos_0149	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Clos_0152	COG2801	Transposase and inactivated derivatives
Clos_0155	COG0860	N-Acetylmuramoyl-L-alanine amidase
Clos_0163	COG1595	DNA-templated transcription, initiation
Clos_0165	COG1024	Enoyl-CoA hydratase
Clos_0166	COG2610	gluconate transmembrane transporter activity
Clos_0169	COG2086	electron transfer activity
Clos_0170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Clos_0171	COG3290	protein histidine kinase activity
Clos_0171	COG3829	transcription factor binding
Clos_0173	COG0723	plastoquinol--plastocyanin reductase activity
Clos_0173	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Clos_0176	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Clos_0177	COG0534	Mate efflux family protein
Clos_0178	COG1053	succinate dehydrogenase
Clos_0178	COG3976	FMN-binding domain protein
Clos_0179	COG2972	Histidine kinase
Clos_0180	COG2207	Transcriptional regulator
Clos_0180	COG4753	response regulator
Clos_0182	COG0739	heme binding
Clos_0183	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Clos_0184	COG0765	amino acid transport
Clos_0185	COG1126	abc transporter atp-binding protein
Clos_0186	COG0840	transmembrane signaling receptor activity
Clos_0187	COG3829	transcription factor binding
Clos_0188	COG1115	amino acid carrier protein
Clos_0189	COG4187	Peptidase family M20/M25/M40
Clos_0190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Clos_0191	COG1687	branched-chain amino acid
Clos_0196	COG1120	ATPase activity
Clos_0203	COG4191	Histidine kinase
Clos_0204	COG2204	response regulator
Clos_0208	COG0746	molybdenum cofactor guanylyltransferase activity
Clos_0209	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Clos_0209	COG0069	glutamate synthase activity
Clos_0210	COG0303	'Molybdopterin
Clos_0214	COG1120	ATPase activity
Clos_0217	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Clos_0221	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Clos_0227	COG0010	Belongs to the arginase family
Clos_0231	COG5002	protein histidine kinase activity
Clos_0233	COG1132	(ABC) transporter
Clos_0237	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Clos_0237	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Clos_0237	COG1013	pyruvate-flavodoxin oxidoreductase activity
Clos_0237	COG0674	pyruvate-flavodoxin oxidoreductase activity
Clos_0238	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Clos_0239	COG2033	superoxide reductase activity
Clos_0241	COG0840	transmembrane signaling receptor activity
Clos_0244	COG0534	Mate efflux family protein
Clos_0245	COG0243	molybdopterin cofactor binding
Clos_0249	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Clos_0250	COG0840	transmembrane signaling receptor activity
Clos_0254	COG1971	Probably functions as a manganese efflux pump
Clos_0256	COG0628	permease
Clos_0257	COG1028	Short-chain dehydrogenase reductase Sdr
Clos_0258	COG0183	Belongs to the thiolase family
Clos_0260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Clos_0265	COG0840	transmembrane signaling receptor activity
Clos_0266	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Clos_0268	COG0581	inorganic phosphate transmembrane transporter activity
Clos_0269	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Clos_0270	COG0704	Plays a role in the regulation of phosphate uptake
Clos_0271	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
Clos_0273	COG1053	succinate dehydrogenase
Clos_0273	COG3976	FMN-binding domain protein
Clos_0278	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Clos_0281	COG2385	sporulation resulting in formation of a cellular spore
Clos_0282	COG4466	Protein conserved in bacteria
Clos_0285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Clos_0286	COG1802	Transcriptional regulator
Clos_0288	COG0697	spore germination
Clos_0289	COG0814	amino acid
Clos_0295	COG3835	regulator
Clos_0297	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Clos_0298	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Clos_0299	COG2195	Cleaves the N-terminal amino acid of tripeptides
Clos_0300	COG2340	Cysteine-rich secretory protein family
Clos_0301	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Clos_0303	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Clos_0307	COG2207	Transcriptional regulator
Clos_0309	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Clos_0311	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_0317	COG0697	spore germination
Clos_0319	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_0320	COG1120	ATPase activity
Clos_0321	COG1131	(ABC) transporter
Clos_0322	COG0842	Transport permease protein
Clos_0324	COG0745	RESPONSE REGULATOR receiver
Clos_0325	COG5002	protein histidine kinase activity
Clos_0326	COG1803	Methylglyoxal synthase
Clos_0331	COG0534	Mate efflux family protein
Clos_0337	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Clos_0340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Clos_0341	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Clos_0348	COG2153	protein acetylation
Clos_0354	COG0840	transmembrane signaling receptor activity
Clos_0355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Clos_0360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Clos_0363	COG1335	isochorismatase
Clos_0364	COG0163	prenyltransferase activity
Clos_0365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Clos_0366	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_0368	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_0369	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_0372	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Clos_0373	COG2252	PERMEase
Clos_0374	COG0402	S-adenosylhomocysteine deaminase activity
Clos_0379	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Clos_0382	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Clos_0383	COG1982	Orn Lys Arg decarboxylase major
Clos_0384	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Clos_0386	COG1607	acyl-coa hydrolase
Clos_0388	COG0745	RESPONSE REGULATOR receiver
Clos_0390	COG1053	succinate dehydrogenase
Clos_0391	COG1902	pentaerythritol trinitrate reductase activity
Clos_0395	COG0439	Biotin carboxylase
Clos_0396	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Clos_0397	COG0825	malonyl-CoA metabolic process
Clos_0399	COG1272	protein, Hemolysin III
Clos_0401	COG1619	proteins homologs of microcin C7 resistance protein MccF
Clos_0402	COG1473	amidohydrolase
Clos_0404	COG2210	Belongs to the sulfur carrier protein TusA family
Clos_0407	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Clos_0408	COG3858	chitin binding
Clos_0408	COG1388	LysM domain
Clos_0410	COG2199	diguanylate cyclase activity
Clos_0411	COG0116	Belongs to the methyltransferase superfamily
Clos_0415	COG1408	metallophosphoesterase
Clos_0416	COG3829	transcription factor binding
Clos_0417	COG0604	alcohol dehydrogenase
Clos_0420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Clos_0421	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Clos_0422	COG5012	cobalamin binding
Clos_0426	COG3279	Response regulator of the LytR AlgR family
Clos_0432	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Clos_0435	COG0427	acetyl-CoA hydrolase
Clos_0436	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Clos_0436	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Clos_0437	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Clos_0437	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Clos_0439	COG0346	lactoylglutathione lyase activity
Clos_0440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Clos_0442	COG4770	biotin carboxylase activity
Clos_0443	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Clos_0444	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Clos_0444	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Clos_0446	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Clos_0447	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Clos_0449	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Clos_0450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Clos_0452	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Clos_0453	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Clos_0454	COG3880	PFAM UvrB UvrC protein
Clos_0455	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Clos_0456	COG0542	response to heat
Clos_0457	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Clos_0460	COG1329	Transcriptional regulator
Clos_0461	COG4956	integral membrane protein (PIN domain superfamily)
Clos_0463	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Clos_0464	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Clos_0465	COG0442	prolyl-tRNA aminoacylation
Clos_0466	COG4086	secreted protein
Clos_0467	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Clos_0468	COG1045	serine acetyltransferase
Clos_0469	COG0215	cysteine-tRNA ligase activity
Clos_0473	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Clos_0474	COG3688	RNA-binding protein containing a PIN domain
Clos_0476	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Clos_0477	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Clos_0479	COG0250	Participates in transcription elongation, termination and antitermination
Clos_0480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Clos_0481	COG0081	regulation of translation
Clos_0482	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Clos_0483	COG0222	ribosome binding
Clos_0484	COG0085	RNA polymerase activity
Clos_0485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Clos_0486	COG1358	cellular component organization or biogenesis
Clos_0487	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Clos_0488	COG0049	tRNA binding
Clos_0489	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Clos_0490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Clos_0491	COG0051	transcription antitermination factor activity, RNA binding
Clos_0492	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Clos_0493	COG0088	Forms part of the polypeptide exit tunnel
Clos_0494	COG0089	rRNA binding
Clos_0495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Clos_0496	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Clos_0497	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Clos_0498	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Clos_0499	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Clos_0500	COG0255	Belongs to the universal ribosomal protein uL29 family
Clos_0501	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Clos_0502	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Clos_0503	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Clos_0504	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Clos_0505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Clos_0506	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Clos_0507	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Clos_0508	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Clos_0509	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Clos_0510	COG1841	ribosomal large subunit assembly
Clos_0511	COG0200	Binds to the 23S rRNA
Clos_0512	COG0201	protein transport
Clos_0513	COG0563	adenylate kinase activity
Clos_0514	COG0024	Methionine aminopeptidase
Clos_0516	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Clos_0517	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Clos_0518	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Clos_0519	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Clos_0520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Clos_0521	COG0202	RNA polymerase activity
Clos_0522	COG0203	ribosomal protein L17
Clos_0523	COG1122	ATPase activity
Clos_0525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Clos_0526	COG0101	tRNA pseudouridine synthase activity
Clos_0527	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Clos_0528	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Clos_0530	COG0860	N-Acetylmuramoyl-L-alanine amidase
Clos_0533	COG0516	GMP reductase activity
Clos_0533	COG0517	IMP dehydrogenase activity
Clos_0535	COG2252	PERMEase
Clos_0536	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Clos_0537	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Clos_0538	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Clos_0539	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Clos_0540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Clos_0541	COG0138	bifunctional purine biosynthesis protein purh
Clos_0542	COG0151	Belongs to the GarS family
Clos_0543	COG0840	transmembrane signaling receptor activity
Clos_0545	COG0527	aspartate kinase activity
Clos_0546	COG1301	dicarboxylic acid transport
Clos_0547	COG1794	racemase activity, acting on amino acids and derivatives
Clos_0548	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Clos_0549	COG0210	DNA helicase
Clos_0550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Clos_0552	COG3069	C4-dicarboxylate transmembrane transporter activity
Clos_0555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Clos_0557	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Clos_0558	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Clos_0559	COG0622	Phosphoesterase
Clos_0562	COG2135	peptidase activity
Clos_0567	COG2195	Cleaves the N-terminal amino acid of tripeptides
Clos_0569	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Clos_0570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Clos_0573	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Clos_0574	COG1660	Displays ATPase and GTPase activities
Clos_0575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Clos_0578	COG1481	regulation of sporulation
Clos_0582	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Clos_0585	COG0205	6-phosphofructokinase activity
Clos_0587	COG1309	transcriptional regulator
Clos_0588	COG1053	succinate dehydrogenase
Clos_0588	COG0431	NADPH-dependent FMN reductase
Clos_0588	COG3976	FMN-binding domain protein
Clos_0595	COG2801	Transposase and inactivated derivatives
Clos_0601	COG1660	Displays ATPase and GTPase activities
Clos_0602	COG1910	domain protein
Clos_0610	COG2205	protein histidine kinase activity
Clos_0611	COG0745	RESPONSE REGULATOR receiver
Clos_0614	COG1215	transferase activity, transferring glycosyl groups
Clos_0617	COG1592	Rubrerythrin
Clos_0620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_0622	COG2985	domain, Protein
Clos_0622	COG0569	domain protein
Clos_0623	COG0045	succinate-CoA ligase (ADP-forming) activity
Clos_0624	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Clos_0626	COG1012	belongs to the aldehyde dehydrogenase family
Clos_0628	COG1609	Transcriptional regulator
Clos_0629	COG1129	ABC transporter
Clos_0632	COG1393	Belongs to the ArsC family
Clos_0635	COG2031	fatty acid transporter
Clos_0636	COG1960	acyl-CoA dehydrogenase activity
Clos_0637	COG2086	electron transfer activity
Clos_0638	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Clos_0639	COG0463	Glycosyl transferase, family 2
Clos_0639	COG0457	Tetratricopeptide repeat
Clos_0642	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Clos_0643	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Clos_0649	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Clos_0651	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Clos_0651	COG1522	sequence-specific DNA binding
Clos_0653	COG3118	belongs to the thioredoxin family
Clos_0654	COG0492	ferredoxin-NADP+ reductase activity
Clos_0655	COG0428	transporter
Clos_0658	COG1164	Oligoendopeptidase f
Clos_0660	COG2884	Cell division ATP-binding protein ftsE
Clos_0661	COG2177	Part of the ABC transporter FtsEX involved in
Clos_0662	COG0546	phosphoglycolate phosphatase activity
Clos_0665	COG0789	Transcriptional regulator
Clos_0667	COG0745	RESPONSE REGULATOR receiver
Clos_0668	COG2205	protein histidine kinase activity
Clos_0668	COG2770	Histidine kinase
Clos_0670	COG1151	hydroxylamine reductase activity
Clos_0671	COG4536	flavin adenine dinucleotide binding
Clos_0672	COG0488	(ABC) transporter
Clos_0673	COG0569	domain protein
Clos_0674	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Clos_0675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Clos_0679	COG2364	Membrane
Clos_0680	COG1876	peptidase activity
Clos_0682	COG2207	Transcriptional regulator
Clos_0684	COG1132	(ABC) transporter
Clos_0685	COG1132	(ABC) transporter
Clos_0686	COG3706	GGDEF domain
Clos_0688	COG1649	PFAM Uncharacterised BCR, COG1649
Clos_0689	COG0116	Belongs to the methyltransferase superfamily
Clos_0689	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Clos_0690	COG0564	pseudouridine synthase activity
Clos_0691	COG3973	AAA domain
Clos_0692	COG1979	alcohol dehydrogenase
Clos_0694	COG1595	DNA-templated transcription, initiation
Clos_0698	COG3853	Toxic anion resistance protein (TelA)
Clos_0701	COG2310	stress, protein
Clos_0702	COG2310	stress, protein
Clos_0705	COG1131	(ABC) transporter
Clos_0708	COG1131	(ABC) transporter
Clos_0711	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Clos_0712	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Clos_0715	COG1242	4 iron, 4 sulfur cluster binding
Clos_0717	COG2357	RelA SpoT domain protein
Clos_0719	COG0191	fructose-bisphosphate aldolase activity
Clos_0720	COG1183	phosphatidylcholine synthase activity
Clos_0721	COG1187	pseudouridine synthase activity
Clos_0722	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Clos_0723	COG0765	amino acid transport
Clos_0725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Clos_0727	COG0745	RESPONSE REGULATOR receiver
Clos_0729	COG0577	efflux transmembrane transporter activity
Clos_0729	COG1136	(ABC) transporter
Clos_0736	COG2801	Transposase and inactivated derivatives
Clos_0744	COG0583	DNA-binding transcription factor activity
Clos_0745	COG0384	phenazine biosynthesis protein PhzF
Clos_0748	COG4191	Histidine kinase
Clos_0750	COG1115	amino acid carrier protein
Clos_0752	COG1309	transcriptional regulator
Clos_0755	COG1136	(ABC) transporter
Clos_0756	COG0789	Transcriptional regulator
Clos_0758	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Clos_0760	COG4716	Myosin-crossreactive antigen
Clos_0761	COG0714	Associated with various cellular activities
Clos_0763	COG2304	oxidoreductase activity
Clos_0766	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Clos_0769	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Clos_0776	COG2155	Conserved Protein
Clos_0777	COG1396	sequence-specific DNA binding
Clos_0780	COG0789	Transcriptional regulator
Clos_0782	COG1595	DNA-templated transcription, initiation
Clos_0785	COG1846	Transcriptional regulator
Clos_0787	COG0745	RESPONSE REGULATOR receiver
Clos_0788	COG5002	protein histidine kinase activity
Clos_0789	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Clos_0792	COG4917	ethanolamine utilization protein
Clos_0793	COG2096	Adenosyltransferase
Clos_0795	COG4810	utilization protein
Clos_0799	COG4816	utilization protein
Clos_0800	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_0801	COG1454	alcohol dehydrogenase
Clos_0801	COG1012	belongs to the aldehyde dehydrogenase family
Clos_0802	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_0804	COG4869	propanediol catabolic process
Clos_0806	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Clos_0807	COG3192	ethanolamine utilization protein
Clos_0813	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Clos_0815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Clos_0816	COG2378	regulation of single-species biofilm formation
Clos_0821	COG1132	(ABC) transporter
Clos_0822	COG4978	Transcriptional regulator
Clos_0822	COG0789	Transcriptional regulator
Clos_0823	COG1408	metallophosphoesterase
Clos_0825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Clos_0826	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Clos_0828	COG2059	Chromate
Clos_0830	COG0583	DNA-binding transcription factor activity
Clos_0831	COG0783	Belongs to the Dps family
Clos_0833	COG0596	Alpha beta hydrolase
Clos_0834	COG3706	GGDEF domain
Clos_0838	COG0697	spore germination
Clos_0839	COG2720	vancomycin resistance protein
Clos_0841	COG1982	Orn Lys Arg decarboxylase major
Clos_0847	COG0604	alcohol dehydrogenase
Clos_0848	COG1846	Transcriptional regulator
Clos_0849	COG1028	Short-chain dehydrogenase reductase Sdr
Clos_0850	COG3274	enterobacterial common antigen metabolic process
Clos_0853	COG0662	Cupin 2, conserved barrel domain protein
Clos_0854	COG2508	Transcriptional regulator
Clos_0858	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Clos_0860	COG2205	protein histidine kinase activity
Clos_0861	COG0745	RESPONSE REGULATOR receiver
Clos_0863	COG1492	cobalamin metabolic process
Clos_0864	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Clos_0865	COG0531	amino acid
Clos_0867	COG2233	PERMEase
Clos_0871	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Clos_0872	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Clos_0873	COG1304	FMN binding
Clos_0875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Clos_0880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Clos_0881	COG0840	transmembrane signaling receptor activity
Clos_0882	COG1971	Probably functions as a manganese efflux pump
Clos_0883	COG0534	Mate efflux family protein
Clos_0884	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Clos_0886	COG0028	Belongs to the TPP enzyme family
Clos_0890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Clos_0891	COG0482	sulfurtransferase activity
Clos_0895	COG0446	pyridine nucleotide-disulphide oxidoreductase
Clos_0897	COG0840	transmembrane signaling receptor activity
Clos_0898	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Clos_0899	COG3546	catalase activity
Clos_0906	COG0681	Belongs to the peptidase S26 family
Clos_0907	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Clos_0908	COG1067	ATP-dependent peptidase activity
Clos_0909	COG0156	8-amino-7-oxononanoate synthase activity
Clos_0910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Clos_0912	COG2720	vancomycin resistance protein
Clos_0915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Clos_0916	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_0917	COG1120	ATPase activity
Clos_0918	COG0735	belongs to the Fur family
Clos_0919	COG0561	phosphatase activity
Clos_0920	COG0737	Belongs to the 5'-nucleotidase family
Clos_0927	COG4948	Mandelate Racemase Muconate Lactonizing
Clos_0934	COG1116	anion transmembrane transporter activity
Clos_0935	COG0668	transmembrane transport
Clos_0936	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Clos_0937	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Clos_0940	COG1595	DNA-templated transcription, initiation
Clos_0943	COG0745	RESPONSE REGULATOR receiver
Clos_0944	COG5002	protein histidine kinase activity
Clos_0946	COG1968	undecaprenyl-diphosphatase activity
Clos_0949	COG4139	cobalamin transport
Clos_0950	COG1120	ATPase activity
Clos_0952	COG1307	EDD domain protein, DegV family
Clos_0955	COG3118	belongs to the thioredoxin family
Clos_0961	COG1744	ABC transporter substrate-binding protein PnrA-like
Clos_0962	COG1328	CTP reductase activity
Clos_0963	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Clos_0967	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Clos_0969	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Clos_0970	COG0126	phosphoglycerate kinase activity
Clos_0971	COG0149	triose-phosphate isomerase activity
Clos_0973	COG0148	phosphopyruvate hydratase activity
Clos_0976	COG3326	Membrane
Clos_0977	COG0557	exoribonuclease II activity
Clos_0978	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Clos_0979	COG0514	ATP-dependent DNA helicase (RecQ)
Clos_0980	COG1136	(ABC) transporter
Clos_0981	COG0577	efflux transmembrane transporter activity
Clos_0982	COG0745	RESPONSE REGULATOR receiver
Clos_0986	COG0542	response to heat
Clos_0991	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Clos_0993	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Clos_0994	COG0564	pseudouridine synthase activity
Clos_0995	COG0500	methyltransferase
Clos_0996	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Clos_0997	COG2205	protein histidine kinase activity
Clos_0999	COG2200	EAL domain
Clos_1001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_1001	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_1002	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Clos_1003	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_1005	COG0500	methyltransferase
Clos_1006	COG2362	D-Aminopeptidase
Clos_1011	COG0310	cobalt ion transport
Clos_1012	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Clos_1014	COG1122	ATPase activity
Clos_1016	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Clos_1017	COG2241	protein methyltransferase activity
Clos_1019	COG2875	Belongs to the precorrin methyltransferase family
Clos_1024	COG2059	Chromate
Clos_1026	COG0583	DNA-binding transcription factor activity
Clos_1027	COG2391	methyltransferase activity
Clos_1029	COG2391	methyltransferase activity
Clos_1035	COG1846	Transcriptional regulator
Clos_1038	COG0037	tRNA processing
Clos_1039	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Clos_1042	COG1983	PspC domain protein
Clos_1045	COG2268	Band 7 protein
Clos_1046	COG0582	viral genome integration into host DNA
Clos_1048	COG1396	sequence-specific DNA binding
Clos_1054	COG1484	DNA-dependent DNA replication
Clos_1056	COG0840	transmembrane signaling receptor activity
Clos_1066	COG2217	Heavy metal translocating P-type atpase
Clos_1073	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Clos_1074	COG0626	cystathionine gamma-synthase activity
Clos_1076	COG2226	methyltransferase
Clos_1078	COG3852	Histidine kinase
Clos_1079	COG2204	response regulator
Clos_1083	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Clos_1084	COG2264	protein methyltransferase activity
Clos_1087	COG2217	Heavy metal translocating P-type atpase
Clos_1092	COG1131	(ABC) transporter
Clos_1093	COG1595	DNA-templated transcription, initiation
Clos_1094	COG2226	methyltransferase
Clos_1095	COG0746	molybdenum cofactor guanylyltransferase activity
Clos_1096	COG0243	molybdopterin cofactor binding
Clos_1097	COG0437	4 iron, 4 sulfur cluster binding
Clos_1099	COG0437	4 iron, 4 sulfur cluster binding
Clos_1101	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Clos_1103	COG0303	'Molybdopterin
Clos_1114	COG0798	PFAM Bile acid sodium symporter
Clos_1116	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Clos_1117	COG0573	inorganic phosphate transmembrane transporter activity
Clos_1118	COG0581	inorganic phosphate transmembrane transporter activity
Clos_1119	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Clos_1120	COG0704	Plays a role in the regulation of phosphate uptake
Clos_1123	COG0701	Predicted permease
Clos_1132	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Clos_1134	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Clos_1136	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Clos_1140	COG1285	pathogenesis
Clos_1152	COG0658	competence protein
Clos_1152	COG2333	competence protein COMEC
Clos_1154	COG0588	phosphoglycerate mutase activity
Clos_1158	COG2094	Belongs to the DNA glycosylase MPG family
Clos_1159	COG1304	FMN binding
Clos_1160	COG0726	polysaccharide deacetylase
Clos_1161	COG3773	Cell wall hydrolase
Clos_1162	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Clos_1163	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Clos_1164	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Clos_1166	COG1164	Oligoendopeptidase f
Clos_1170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Clos_1171	COG0564	pseudouridine synthase activity
Clos_1173	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Clos_1177	COG2244	polysaccharide biosynthetic process
Clos_1180	COG1132	(ABC) transporter
Clos_1181	COG1132	(ABC) transporter
Clos_1183	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Clos_1184	COG1597	lipid kinase activity
Clos_1185	COG1846	Transcriptional regulator
Clos_1186	COG2203	Gaf domain
Clos_1186	COG2199	diguanylate cyclase activity
Clos_1187	COG2986	histidine ammonia-lyase
Clos_1188	COG1228	amidohydrolase
Clos_1191	COG4224	UPF0291 protein
Clos_1192	COG0835	chemotaxis
Clos_1196	COG1307	EDD domain protein, DegV family
Clos_1197	COG0583	DNA-binding transcription factor activity
Clos_1198	COG2357	RelA SpoT domain protein
Clos_1199	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Clos_1200	COG1136	(ABC) transporter
Clos_1201	COG1136	(ABC) transporter
Clos_1201	COG0577	efflux transmembrane transporter activity
Clos_1203	COG5002	protein histidine kinase activity
Clos_1204	COG1595	DNA-templated transcription, initiation
Clos_1206	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Clos_1206	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Clos_1211	COG0242	peptide deformylase activity
Clos_1212	COG0402	S-adenosylhomocysteine deaminase activity
Clos_1217	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Clos_1218	COG0513	Belongs to the DEAD box helicase family
Clos_1221	COG2333	competence protein COMEC
Clos_1221	COG0658	competence protein
Clos_1223	COG0658	competence protein
Clos_1223	COG2333	competence protein COMEC
Clos_1225	COG0268	Binds directly to 16S ribosomal RNA
Clos_1229	COG0481	GTPase activity
Clos_1230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Clos_1231	COG1420	regulation of RNA biosynthetic process
Clos_1232	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Clos_1233	COG0443	Heat shock 70 kDa protein
Clos_1235	COG2264	protein methyltransferase activity
Clos_1236	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Clos_1237	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Clos_1238	COG0537	adenosine 5'-monophosphoramidase activity
Clos_1239	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Clos_1240	COG1610	YqeY-like protein
Clos_1242	COG4864	UPF0365 protein
Clos_1246	COG1702	phosphate starvation-inducible protein PhoH
Clos_1247	COG1480	7TM receptor with intracellular HD hydrolase
Clos_1248	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Clos_1249	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Clos_1251	COG0295	cytidine deaminase activity
Clos_1252	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Clos_1253	COG1381	Involved in DNA repair and RecF pathway recombination
Clos_1254	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Clos_1255	COG0423	glycine-tRNA ligase activity
Clos_1256	COG0517	IMP dehydrogenase activity
Clos_1257	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Clos_1258	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Clos_1258	COG0574	Belongs to the PEP-utilizing enzyme family
Clos_1270	COG1695	Transcriptional regulator
Clos_1274	COG3655	Transcriptional regulator
Clos_1277	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Clos_1278	COG0358	DNA primase activity
Clos_1279	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Clos_1281	COG2384	SAM-dependent methyltransferase
Clos_1282	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Clos_1284	COG0582	viral genome integration into host DNA
Clos_1286	COG1917	Cupin 2, conserved barrel domain protein
Clos_1286	COG1396	sequence-specific DNA binding
Clos_1290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Clos_1294	COG0358	DNA primase activity
Clos_1320	COG2003	Belongs to the UPF0758 family
Clos_1322	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Clos_1323	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Clos_1324	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Clos_1327	COG0181	hydroxymethylbilane synthase activity
Clos_1329	COG0113	porphobilinogen synthase activity
Clos_1330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Clos_1332	COG1970	mechanosensitive ion channel activity
Clos_1334	COG1966	Carbon starvation protein
Clos_1335	COG3279	Response regulator of the LytR AlgR family
Clos_1336	COG3275	phosphorelay sensor kinase activity
Clos_1340	COG0494	nUDIX hydrolase
Clos_1342	COG0601	transmembrane transport
Clos_1343	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Clos_1344	COG0444	Belongs to the ABC transporter superfamily
Clos_1345	COG4608	Belongs to the ABC transporter superfamily
Clos_1346	COG2030	dehydratase
Clos_1347	COG0747	negative chemotaxis
Clos_1350	COG0444	Belongs to the ABC transporter superfamily
Clos_1351	COG4608	Belongs to the ABC transporter superfamily
Clos_1352	COG2096	Adenosyltransferase
Clos_1357	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Clos_1358	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Clos_1359	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Clos_1360	COG4869	propanediol catabolic process
Clos_1361	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Clos_1364	COG0012	GTP binding
Clos_1367	COG0612	Peptidase, M16
Clos_1370	COG2001	Belongs to the MraZ family
Clos_1371	COG0275	rRNA processing
Clos_1373	COG0768	penicillin binding
Clos_1374	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Clos_1375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Clos_1376	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Clos_1377	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Clos_1378	COG0772	Belongs to the SEDS family
Clos_1379	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Clos_1380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Clos_1384	COG3856	small basic protein
Clos_1385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Clos_1387	COG1191	sigma factor activity
Clos_1388	COG1191	sigma factor activity
Clos_1389	COG1873	PFAM PRC-barrel domain
Clos_1390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Clos_1392	COG0745	RESPONSE REGULATOR receiver
Clos_1393	COG5002	protein histidine kinase activity
Clos_1399	COG1160	GTP binding
Clos_1400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Clos_1401	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Clos_1407	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Clos_1408	COG1799	cell septum assembly
Clos_1410	COG2302	S4 RNA-binding domain
Clos_1411	COG3599	regulation of cell shape
Clos_1412	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Clos_1413	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Clos_1415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Clos_1417	COG0564	pseudouridine synthase activity
Clos_1418	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Clos_1420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Clos_1421	COG1561	YicC-like family, N-terminal region
Clos_1422	COG2052	Domain of unknown function (DUF370)
Clos_1424	COG1758	RNA polymerase activity
Clos_1425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Clos_1426	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Clos_1427	COG0242	peptide deformylase activity
Clos_1428	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Clos_1430	COG2738	Putative neutral zinc metallopeptidase
Clos_1431	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Clos_1431	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Clos_1432	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Clos_1433	COG0631	protein serine/threonine phosphatase activity
Clos_1434	COG0515	serine threonine protein kinase
Clos_1434	COG2815	serine threonine protein kinase
Clos_1435	COG1162	GTPase activity
Clos_1436	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Clos_1437	COG1564	THIamine pyrophosphokinase
Clos_1438	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Clos_1439	COG1302	Protein conserved in bacteria
Clos_1440	COG1461	Dihydroxyacetone kinase
Clos_1441	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Clos_1442	COG0742	ribosomal rna small subunit methyltransferase
Clos_1443	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Clos_1445	COG3314	Sporulation integral membrane protein YlbJ
Clos_1446	COG1323	Belongs to the UPF0348 family
Clos_1447	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Clos_1448	COG1399	metal-binding, possibly nucleic acid-binding protein
Clos_1449	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Clos_1450	COG2030	dehydratase
Clos_1451	COG0416	fatty acid biosynthetic process
Clos_1452	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Clos_1453	COG2070	2-Nitropropane dioxygenase
Clos_1454	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Clos_1455	COG1028	Short-chain dehydrogenase reductase Sdr
Clos_1456	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Clos_1457	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Clos_1458	COG0571	ribonuclease III activity
Clos_1459	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Clos_1460	COG1196	nuclear chromosome segregation
Clos_1461	COG0552	protein localization to endoplasmic reticulum
Clos_1462	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Clos_1463	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Clos_1464	COG0228	four-way junction DNA binding
Clos_1465	COG1837	Belongs to the UPF0109 family
Clos_1466	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Clos_1467	COG0336	Belongs to the RNA methyltransferase TrmD family
Clos_1468	COG0335	large ribosomal subunit rRNA binding
Clos_1469	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Clos_1470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Clos_1471	COG0792	nuclease activity
Clos_1473	COG0758	DNA mediated transformation
Clos_1474	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Clos_1476	COG1815	bacterial-type flagellum-dependent cell motility
Clos_1477	COG1558	bacterial-type flagellum-dependent cell motility
Clos_1478	COG1677	Flagellar hook-basal body complex protein FliE
Clos_1479	COG1766	The M ring may be actively involved in energy transduction
Clos_1480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Clos_1482	COG1157	protein secretion by the type III secretion system
Clos_1486	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Clos_1490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Clos_1491	COG1360	Flagellar Motor Protein
Clos_1494	COG1776	CheC inhibitor of MCP methylation
Clos_1494	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Clos_1495	COG2201	protein-glutamate methylesterase activity
Clos_1497	COG1338	Plays a role in the flagellum-specific transport system
Clos_1498	COG1987	bacterial-type flagellum assembly
Clos_1499	COG1684	flagellar biosynthetic protein fliR
Clos_1500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Clos_1501	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Clos_1502	COG1419	protein localization to endoplasmic reticulum
Clos_1503	COG0455	bacterial-type flagellum organization
Clos_1504	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Clos_1505	COG2201	protein-glutamate methylesterase activity
Clos_1506	COG0643	Histidine kinase
Clos_1506	COG2198	Histidine kinase
Clos_1507	COG0835	chemotaxis
Clos_1508	COG1776	CheC inhibitor of MCP methylation
Clos_1509	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Clos_1510	COG1191	sigma factor activity
Clos_1513	COG0052	Belongs to the universal ribosomal protein uS2 family
Clos_1514	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Clos_1515	COG0528	UMP kinase activity
Clos_1516	COG0233	cytoplasmic translational termination
Clos_1518	COG4589	Belongs to the CDS family
Clos_1519	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Clos_1520	COG0750	zinc metalloprotease
Clos_1522	COG0463	Glycosyl transferase, family 2
Clos_1524	COG0779	Required for maturation of 30S ribosomal subunits
Clos_1525	COG0195	Participates in both transcription termination and antitermination
Clos_1526	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Clos_1528	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Clos_1529	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Clos_1530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Clos_1531	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Clos_1532	COG0196	riboflavin kinase activity
Clos_1533	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Clos_1534	COG1185	polyribonucleotide nucleotidyltransferase activity
Clos_1535	COG0726	polysaccharide deacetylase
Clos_1536	COG0612	Peptidase, M16
Clos_1538	COG0740	serine-type endopeptidase activity
Clos_1539	COG1674	ftsk spoiiie
Clos_1540	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Clos_1541	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Clos_1543	COG1418	mRNA catabolic process
Clos_1544	COG2359	stage V sporulation protein S
Clos_1545	COG0613	PHP domain protein
Clos_1547	COG3858	chitin binding
Clos_1548	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Clos_1549	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Clos_1550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Clos_1551	COG1923	regulation of RNA biosynthetic process
Clos_1552	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Clos_1553	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Clos_1554	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Clos_1555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Clos_1558	COG1363	Peptidase, m42
Clos_1559	COG1363	Peptidase, m42
Clos_1560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Clos_1561	COG0539	negative regulation of cytoplasmic translation
Clos_1561	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Clos_1562	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Clos_1563	COG0204	Acyl-transferase
Clos_1564	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Clos_1566	COG2081	HI0933 family
Clos_1567	COG0406	alpha-ribazole phosphatase activity
Clos_1568	COG1737	Transcriptional regulator
Clos_1570	COG1013	pyruvate-flavodoxin oxidoreductase activity
Clos_1571	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Clos_1571	COG0674	pyruvate-flavodoxin oxidoreductase activity
Clos_1575	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Clos_1577	COG1187	pseudouridine synthase activity
Clos_1578	COG0445	tRNA wobble uridine modification
Clos_1580	COG1686	Belongs to the peptidase S11 family
Clos_1582	COG3874	Sporulation protein YtfJ
Clos_1585	COG0010	Belongs to the arginase family
Clos_1586	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Clos_1587	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Clos_1588	COG1686	Belongs to the peptidase S11 family
Clos_1590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Clos_1592	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Clos_1593	COG4974	Belongs to the 'phage' integrase family
Clos_1598	COG0463	Glycosyl transferase, family 2
Clos_1601	COG2137	regulation of response to DNA damage stimulus
Clos_1603	COG0750	zinc metalloprotease
Clos_1604	COG0497	DNA recombination
Clos_1605	COG1438	arginine binding
Clos_1606	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Clos_1607	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Clos_1608	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Clos_1609	COG0142	geranyltranstransferase activity
Clos_1610	COG1722	exodeoxyribonuclease VII activity
Clos_1611	COG1570	exodeoxyribonuclease VII activity
Clos_1613	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Clos_1614	COG1302	Protein conserved in bacteria
Clos_1622	COG3854	ATPases associated with a variety of cellular activities
Clos_1624	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Clos_1625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Clos_1634	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Clos_1638	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Clos_1639	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Clos_1641	COG1191	sigma factor activity
Clos_1653	COG1191	sigma factor activity
Clos_1654	COG0768	penicillin binding
Clos_1655	COG0572	uridine kinase
Clos_1660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Clos_1661	COG0735	belongs to the Fur family
Clos_1662	COG3906	Belongs to the UPF0473 family
Clos_1665	COG4472	Bacterial protein of unknown function (DUF965)
Clos_1666	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Clos_1667	COG0628	permease
Clos_1671	COG1959	2 iron, 2 sulfur cluster binding
Clos_1672	COG2340	Cysteine-rich secretory protein family
Clos_1676	COG0326	Molecular chaperone. Has ATPase activity
Clos_1678	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Clos_1683	COG1234	tRNA 3'-trailer cleavage
Clos_1688	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Clos_1693	COG3457	Alanine racemase
Clos_1695	COG5012	cobalamin binding
Clos_1697	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Clos_1699	COG3804	dihydrodipicolinate reductase
Clos_1700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Clos_1704	COG1362	aminopeptidase activity
Clos_1707	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Clos_1710	COG0124	histidyl-tRNA synthetase
Clos_1711	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Clos_1712	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Clos_1713	COG1490	D-aminoacyl-tRNA deacylase activity
Clos_1714	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Clos_1715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Clos_1716	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Clos_1716	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Clos_1721	COG1862	Preprotein translocase
Clos_1724	COG2385	sporulation resulting in formation of a cellular spore
Clos_1724	COG2247	cell wall binding repeat
Clos_1725	COG2255	four-way junction helicase activity
Clos_1726	COG0632	four-way junction helicase activity
Clos_1727	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Clos_1728	COG1067	ATP-dependent peptidase activity
Clos_1730	COG1268	BioY protein
Clos_1731	COG1187	pseudouridine synthase activity
Clos_1733	COG5002	protein histidine kinase activity
Clos_1734	COG0745	RESPONSE REGULATOR receiver
Clos_1736	COG1921	L-seryl-tRNASec selenium transferase activity
Clos_1737	COG1115	amino acid carrier protein
Clos_1739	COG1555	photosystem II stabilization
Clos_1740	COG1686	Belongs to the peptidase S11 family
Clos_1741	COG1760	l-serine dehydratase
Clos_1742	COG1760	l-serine dehydratase
Clos_1743	COG0251	oxidation-reduction process
Clos_1745	COG0799	negative regulation of ribosome biogenesis
Clos_1746	COG1316	TRANSCRIPTIONal
Clos_1747	COG1713	HD superfamily hydrolase involved in NAD metabolism
Clos_1748	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Clos_1750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Clos_1751	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Clos_1753	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Clos_1754	COG1530	ribonuclease E activity
Clos_1757	COG1994	Peptidase M50
Clos_1759	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Clos_1760	COG2894	cell division
Clos_1762	COG0768	penicillin binding
Clos_1765	COG1077	Cell shape determining protein MreB Mrl
Clos_1766	COG2003	Belongs to the UPF0758 family
Clos_1767	COG0424	maF-like protein
Clos_1770	COG2878	Part of a membrane complex involved in electron transport
Clos_1770	COG1245	4Fe-4S binding domain
Clos_1771	COG4657	Part of a membrane complex involved in electron transport
Clos_1772	COG4660	Part of a membrane complex involved in electron transport
Clos_1773	COG4659	FMN binding
Clos_1774	COG4658	electron transport chain
Clos_1775	COG4656	Part of a membrane complex involved in electron transport
Clos_1777	COG0791	NLP P60 protein
Clos_1777	COG1388	LysM domain
Clos_1778	COG0217	transcriptional regulatory protein
Clos_1779	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Clos_1781	COG0730	response to heat
Clos_1783	COG1739	Uncharacterized protein family UPF0029
Clos_1786	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Clos_1794	COG1191	sigma factor activity
Clos_1797	COG0519	Catalyzes the synthesis of GMP from XMP
Clos_1798	COG1335	isochorismatase
Clos_1805	COG2851	Citrate transporter
Clos_1806	COG3829	transcription factor binding
Clos_1806	COG3290	protein histidine kinase activity
Clos_1808	COG0534	Mate efflux family protein
Clos_1809	COG0456	acetyltransferase
Clos_1811	COG0521	Mo-molybdopterin cofactor biosynthetic process
Clos_1812	COG0315	cyclic pyranopterin monophosphate synthase activity
Clos_1813	COG0301	tRNA thio-modification
Clos_1814	COG1104	cysteine desulfurase activity
Clos_1817	COG0210	DNA helicase
Clos_1821	COG1396	sequence-specific DNA binding
Clos_1828	COG0280	phosphate acetyltransferase
Clos_1831	COG1032	radical SAM domain protein
Clos_1835	COG1683	Conserved Protein
Clos_1836	COG1193	negative regulation of DNA recombination
Clos_1838	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Clos_1839	COG2081	HI0933 family
Clos_1840	COG1592	Rubrerythrin
Clos_1842	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Clos_1843	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Clos_1853	COG3620	sequence-specific DNA binding
Clos_1890	COG3541	Predicted nucleotidyltransferase
Clos_1893	COG2801	Transposase and inactivated derivatives
Clos_1894	COG2963	transposase activity
Clos_1921	COG3177	Filamentation induced by cAMP protein fic
Clos_1923	COG1475	DNA binding
Clos_1924	COG1192	Involved in chromosome partitioning
Clos_1936	COG0598	Magnesium transport protein CorA
Clos_1937	COG2267	carboxylic ester hydrolase activity
Clos_1938	COG1690	Belongs to the RtcB family
Clos_1939	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Clos_1940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Clos_1943	COG1058	Belongs to the CinA family
Clos_1943	COG1546	Belongs to the CinA family
Clos_1944	COG1388	LysM domain
Clos_1944	COG1705	Flagellar rod assembly protein muramidase FlgJ
Clos_1945	COG1132	(ABC) transporter
Clos_1946	COG1132	(ABC) transporter
Clos_1950	COG0426	domain, Protein
Clos_1951	COG2233	PERMEase
Clos_1955	COG0083	homoserine kinase activity
Clos_1956	COG4492	Belongs to the UPF0735 family
Clos_1960	COG0835	chemotaxis
Clos_1960	COG0784	Response regulator, receiver
Clos_1965	COG3608	succinylglutamate desuccinylase aspartoacylase
Clos_1965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Clos_1966	COG0534	Mate efflux family protein
Clos_1967	COG1666	GTP binding
Clos_1970	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Clos_1971	COG0072	phenylalanine-tRNA ligase activity
Clos_1971	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_1972	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Clos_1973	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Clos_1974	COG0569	domain protein
Clos_1975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Clos_1976	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Clos_1977	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Clos_1978	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Clos_1981	COG4399	Belongs to the UPF0754 family
Clos_1984	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Clos_1985	COG3344	reverse transcriptase
Clos_1986	COG0222	ribosome binding
Clos_1987	COG2801	Transposase and inactivated derivatives
Clos_1988	COG2963	transposase activity
Clos_1998	COG5566	PFAM Mor transcription activator
Clos_2000	COG2963	transposase activity
Clos_2001	COG2801	Transposase and inactivated derivatives
Clos_2003	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Clos_2005	COG1278	Cold shock
Clos_2006	COG2226	methyltransferase
Clos_2008	COG2066	Belongs to the glutaminase family
Clos_2009	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Clos_2010	COG0517	IMP dehydrogenase activity
Clos_2017	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Clos_2018	COG0726	polysaccharide deacetylase
Clos_2021	COG4175	Glycine betaine
Clos_2021	COG0517	IMP dehydrogenase activity
Clos_2022	COG1510	regulation of RNA biosynthetic process
Clos_2023	COG0436	Aminotransferase
Clos_2024	COG1283	sodium-dependent phosphate transmembrane transporter activity
Clos_2028	COG0285	dihydrofolate synthase activity
Clos_2033	COG1074	ATP-dependent DNA helicase activity
Clos_2034	COG0443	Heat shock 70 kDa protein
Clos_2038	COG0525	valine-tRNA ligase activity
Clos_2039	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Clos_2041	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Clos_2047	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Clos_2049	COG2608	mercury ion transmembrane transporter activity
Clos_2050	COG3681	Belongs to the UPF0597 family
Clos_2054	COG0384	phenazine biosynthesis protein PhzF
Clos_2055	COG1741	Belongs to the pirin family
Clos_2056	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Clos_2065	COG2244	polysaccharide biosynthetic process
Clos_2066	COG0488	(ABC) transporter
Clos_2068	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Clos_2072	COG3773	Cell wall hydrolase
Clos_2072	COG3409	Peptidoglycan-binding domain 1 protein
Clos_2073	COG2239	Acts as a magnesium transporter
Clos_2074	COG0772	Belongs to the SEDS family
Clos_2075	COG0840	transmembrane signaling receptor activity
Clos_2081	COG0577	efflux transmembrane transporter activity
Clos_2082	COG1136	(ABC) transporter
Clos_2083	COG2205	protein histidine kinase activity
Clos_2084	COG0745	RESPONSE REGULATOR receiver
Clos_2085	COG3872	metal-dependent enzyme
Clos_2088	COG0312	modulator of DNA gyrase
Clos_2093	COG1116	anion transmembrane transporter activity
Clos_2094	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Clos_2095	COG3437	response regulator, receiver
Clos_2099	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Clos_2099	COG2199	diguanylate cyclase activity
Clos_2100	COG2770	Histidine kinase
Clos_2100	COG2208	phosphoserine phosphatase activity
Clos_2101	COG1053	succinate dehydrogenase
Clos_2101	COG3976	FMN-binding domain protein
Clos_2102	COG1053	succinate dehydrogenase
Clos_2102	COG3976	FMN-binding domain protein
Clos_2103	COG4939	FMN-binding domain protein
Clos_2104	COG1477	protein flavinylation
Clos_2107	COG4242	Belongs to the peptidase S51 family
Clos_2108	COG0726	polysaccharide deacetylase
Clos_2109	COG1283	sodium-dependent phosphate transmembrane transporter activity
Clos_2110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Clos_2113	COG0746	molybdenum cofactor guanylyltransferase activity
Clos_2114	COG2996	Protein conserved in bacteria
Clos_2118	COG1307	EDD domain protein, DegV family
Clos_2120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Clos_2123	COG0180	Tryptophanyl-tRNA synthetase
Clos_2124	COG0674	pyruvate-flavodoxin oxidoreductase activity
Clos_2124	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Clos_2125	COG1013	pyruvate-flavodoxin oxidoreductase activity
Clos_2127	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Clos_2128	COG0840	transmembrane signaling receptor activity
Clos_2132	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Clos_2134	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Clos_2135	COG1121	(ABC) transporter
Clos_2136	COG0803	Belongs to the bacterial solute-binding protein 9 family
Clos_2136	COG3443	Belongs to the bacterial solute-binding protein 9 family
Clos_2137	COG0805	protein transport
Clos_2139	COG0069	glutamate synthase activity
Clos_2139	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Clos_2140	COG2414	aldehyde ferredoxin oxidoreductase
Clos_2141	COG0437	4 iron, 4 sulfur cluster binding
Clos_2142	COG3608	succinylglutamate desuccinylase aspartoacylase
Clos_2142	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Clos_2143	COG2414	aldehyde ferredoxin oxidoreductase
Clos_2144	COG0437	4 iron, 4 sulfur cluster binding
Clos_2146	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Clos_2147	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Clos_2149	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Clos_2150	COG1924	4 iron, 4 sulfur cluster binding
Clos_2153	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Clos_2154	COG3706	GGDEF domain
Clos_2157	COG0285	dihydrofolate synthase activity
Clos_2158	COG4608	Belongs to the ABC transporter superfamily
Clos_2159	COG0444	Belongs to the ABC transporter superfamily
Clos_2160	COG0601	transmembrane transport
Clos_2161	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Clos_2162	COG2217	Heavy metal translocating P-type atpase
Clos_2165	COG2205	protein histidine kinase activity
Clos_2166	COG0745	RESPONSE REGULATOR receiver
Clos_2168	COG1773	rubredoxin
Clos_2170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Clos_2172	COG1067	ATP-dependent peptidase activity
Clos_2172	COG0470	DNA polymerase III
Clos_2173	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Clos_2174	COG0740	serine-type endopeptidase activity
Clos_2175	COG0544	peptidyl-prolyl cis-trans isomerase activity
Clos_2176	COG1278	Cold shock
Clos_2178	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Clos_2179	COG0426	domain, Protein
Clos_2181	COG0549	Belongs to the carbamate kinase family
Clos_2183	COG1595	DNA-templated transcription, initiation
Clos_2185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Clos_2186	COG0460	homoserine dehydrogenase
Clos_2188	COG0540	Belongs to the ATCase OTCase family
Clos_2190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Clos_2191	COG0167	dihydroorotate dehydrogenase activity
Clos_2192	COG0543	2 iron, 2 sulfur cluster binding
Clos_2193	COG0284	orotidine-5'-phosphate decarboxylase activity
Clos_2196	COG2323	membrane
Clos_2197	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Clos_2199	COG3706	GGDEF domain
Clos_2202	COG0700	Nucleoside recognition
Clos_2203	COG2715	membrane protein required for spore maturation
Clos_2204	COG0840	transmembrane signaling receptor activity
Clos_2209	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Clos_2210	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Clos_2211	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Clos_2214	COG5564	TIM-barrel signal transduction protein
Clos_2217	COG3192	ethanolamine utilization protein
Clos_2218	COG0860	N-Acetylmuramoyl-L-alanine amidase
Clos_2223	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Clos_2224	COG0363	glucosamine-6-phosphate deaminase activity
Clos_2227	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Clos_2232	COG2801	Transposase and inactivated derivatives
Clos_2233	COG2963	transposase activity
Clos_2246	COG3290	protein histidine kinase activity
Clos_2247	COG3279	Response regulator of the LytR AlgR family
Clos_2250	COG1034	ATP synthesis coupled electron transport
Clos_2255	COG0322	excinuclease ABC activity
Clos_2257	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Clos_2258	COG0556	nucleotide-excision repair
Clos_2259	COG0793	Belongs to the peptidase S41A family
Clos_2260	COG4942	peptidase
Clos_2261	COG2177	Part of the ABC transporter FtsEX involved in
Clos_2262	COG2884	Cell division ATP-binding protein ftsE
Clos_2263	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Clos_2266	COG3958	Transketolase
Clos_2267	COG3959	Transketolase, thiamine diphosphate binding domain
Clos_2268	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Clos_2269	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Clos_2273	COG2337	Toxic component of a toxin-antitoxin (TA) module
Clos_2275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Clos_2276	COG0736	holo-[acyl-carrier-protein] synthase activity
Clos_2281	COG1910	domain protein
Clos_2282	COG3842	ATPase activity
Clos_2283	COG4149	molybdate abc transporter
Clos_2284	COG0725	ABC transporter, periplasmic molybdate-binding protein
Clos_2286	COG2056	Na+-H+ antiporter family
Clos_2287	COG0531	amino acid
Clos_2288	COG0419	ATPase involved in DNA repair
Clos_2289	COG0420	3'-5' exonuclease activity
Clos_2290	COG1074	ATP-dependent DNA helicase activity
Clos_2291	COG1194	a g-specific adenine glycosylase
Clos_2299	COG0488	(ABC) transporter
Clos_2300	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Clos_2302	COG4868	Belongs to the UPF0371 family
Clos_2304	COG0436	Aminotransferase
Clos_2306	COG0371	Dehydrogenase
Clos_2307	COG3976	FMN-binding domain protein
Clos_2307	COG0431	NADPH-dependent FMN reductase
Clos_2307	COG1053	succinate dehydrogenase
Clos_2309	COG1994	Peptidase M50
Clos_2310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Clos_2312	COG0697	spore germination
Clos_2314	COG1363	Peptidase, m42
Clos_2318	COG0708	Exodeoxyribonuclease III
Clos_2321	COG3708	Transcriptional regulator
Clos_2321	COG2207	Transcriptional regulator
Clos_2328	COG1429	ligase activity, forming nitrogen-metal bonds
Clos_2329	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_2331	COG1592	Rubrerythrin
Clos_2332	COG0688	phosphatidylethanolamine metabolic process
Clos_2337	COG0710	3-dehydroquinate dehydratase activity
Clos_2338	COG2070	2-Nitropropane dioxygenase
Clos_2341	COG0017	Asparaginyl-tRNA synthetase
Clos_2342	COG0583	DNA-binding transcription factor activity
Clos_2344	COG1301	dicarboxylic acid transport
Clos_2346	COG0726	polysaccharide deacetylase
Clos_2348	COG0242	peptide deformylase activity
Clos_2352	COG1695	Transcriptional regulator
Clos_2353	COG2814	Major facilitator Superfamily
Clos_2355	COG0346	lactoylglutathione lyase activity
Clos_2358	COG0011	TIGRFAM Protein of
Clos_2359	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Clos_2361	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Clos_2362	COG3829	transcription factor binding
Clos_2362	COG3290	protein histidine kinase activity
Clos_2363	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Clos_2364	COG1333	cytochrome c biogenesis protein
Clos_2365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Clos_2368	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
Clos_2370	COG0840	transmembrane signaling receptor activity
Clos_2371	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Clos_2373	COG1472	Belongs to the glycosyl hydrolase 3 family
Clos_2375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Clos_2382	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Clos_2384	COG0840	transmembrane signaling receptor activity
Clos_2385	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_2386	COG4869	propanediol catabolic process
Clos_2387	COG1454	alcohol dehydrogenase
Clos_2387	COG1012	belongs to the aldehyde dehydrogenase family
Clos_2388	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_2391	COG4656	Part of a membrane complex involved in electron transport
Clos_2393	COG4820	ethanolamine utilization protein (EutJ)
Clos_2396	COG4810	utilization protein
Clos_2397	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Clos_2398	COG1882	Formate acetyltransferase
Clos_2399	COG1454	alcohol dehydrogenase
Clos_2399	COG1012	belongs to the aldehyde dehydrogenase family
Clos_2400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_2401	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Clos_2405	COG1012	belongs to the aldehyde dehydrogenase family
Clos_2405	COG1454	alcohol dehydrogenase
Clos_2406	COG3275	phosphorelay sensor kinase activity
Clos_2413	COG3426	butyrate kinase activity
Clos_2414	COG0280	phosphate acetyltransferase
Clos_2415	COG3829	transcription factor binding
Clos_2415	COG3290	protein histidine kinase activity
Clos_2417	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Clos_2418	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Clos_2418	COG5322	oxidoreductase activity
Clos_2422	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Clos_2424	COG2323	membrane
Clos_2425	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Clos_2426	COG4536	flavin adenine dinucleotide binding
Clos_2427	COG1376	ErfK ybiS ycfS ynhG family protein
Clos_2428	COG1120	ATPase activity
Clos_2429	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_2430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_2433	COG0671	phosphoesterase, PA-phosphatase related
Clos_2442	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Clos_2443	COG3246	L-lysine catabolic process to acetate
Clos_2445	COG3829	transcription factor binding
Clos_2445	COG3290	protein histidine kinase activity
Clos_2447	COG0459	protein refolding
Clos_2448	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Clos_2454	COG1131	(ABC) transporter
Clos_2455	COG0167	dihydroorotate dehydrogenase activity
Clos_2457	COG0402	S-adenosylhomocysteine deaminase activity
Clos_2458	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Clos_2461	COG2221	Nitrite and sulphite reductase 4Fe-4S
Clos_2464	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Clos_2465	COG0488	(ABC) transporter
Clos_2468	COG0456	acetyltransferase
Clos_2469	COG1214	PFAM Peptidase M22, glycoprotease
Clos_2470	COG0802	atpase or kinase
Clos_2472	COG2207	Transcriptional regulator
Clos_2472	COG4753	response regulator
Clos_2473	COG4251	negative regulation of phosphorylation
Clos_2474	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Clos_2476	COG1228	amidohydrolase
Clos_2477	COG2183	response to ionizing radiation
Clos_2480	COG2257	FlhB HrpN YscU SpaS Family
Clos_2483	COG0840	transmembrane signaling receptor activity
Clos_2484	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Clos_2485	COG0653	protein targeting
Clos_2487	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Clos_2489	COG1516	flagellar protein fliS
Clos_2490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Clos_2493	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Clos_2494	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Clos_2495	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Clos_2496	COG3829	transcription factor binding
Clos_2497	COG1757	Na H antiporter
Clos_2499	COG0411	ABC transporter
Clos_2501	COG0559	Belongs to the binding-protein-dependent transport system permease family
Clos_2510	COG2089	acid synthase
Clos_2513	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Clos_2514	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Clos_2515	COG1086	Polysaccharide biosynthesis protein
Clos_2518	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Clos_2519	COG0840	transmembrane signaling receptor activity
Clos_2521	COG1256	bacterial-type flagellum assembly
Clos_2521	COG4786	Flagellar basal body rod
Clos_2525	COG1040	competence protein
Clos_2526	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Clos_2530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Clos_2531	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Clos_2534	COG3906	Belongs to the UPF0473 family
Clos_2536	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Clos_2537	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Clos_2538	COG1177	transmembrane transport
Clos_2539	COG1176	ABC-type spermidine putrescine transport system, permease component I
Clos_2540	COG3842	ATPase activity
Clos_2542	COG1285	pathogenesis
Clos_2543	COG2610	gluconate transmembrane transporter activity
Clos_2545	COG3395	kinase activity
Clos_2546	COG1349	DNA-binding transcription factor activity
Clos_2547	COG3942	CHAP domain
Clos_2547	COG1388	LysM domain
Clos_2550	COG4786	Flagellar basal body rod
Clos_2552	COG1609	Transcriptional regulator
Clos_2554	COG2385	sporulation resulting in formation of a cellular spore
Clos_2555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Clos_2559	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Clos_2560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Clos_2561	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Clos_2562	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Clos_2563	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Clos_2564	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Clos_2565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Clos_2569	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Clos_2570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Clos_2571	COG2131	deaminase
Clos_2572	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Clos_2573	COG0698	ribose 5-phosphate isomerase
Clos_2574	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Clos_2575	COG0009	L-threonylcarbamoyladenylate synthase
Clos_2576	COG0768	penicillin binding
Clos_2578	COG1716	ATPase activity
Clos_2580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Clos_2581	COG2890	protein-(glutamine-N5) methyltransferase activity
Clos_2582	COG3872	metal-dependent enzyme
Clos_2583	COG0842	Transport permease protein
Clos_2585	COG1131	(ABC) transporter
Clos_2587	COG0495	leucyl-tRNA aminoacylation
Clos_2589	COG1435	thymidine kinase activity
Clos_2590	COG0254	rRNA binding
Clos_2591	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Clos_2593	COG0765	amino acid transport
Clos_2594	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Clos_2595	COG1494	fructose-1,6-bisphosphatase
Clos_2596	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Clos_2597	COG3246	L-lysine catabolic process to acetate
Clos_2598	COG1607	acyl-coa hydrolase
Clos_2599	COG0733	neurotransmitter:sodium symporter activity
Clos_2600	COG0733	neurotransmitter:sodium symporter activity
Clos_2602	COG2373	Large extracellular alpha-helical protein
Clos_2609	COG0840	transmembrane signaling receptor activity
Clos_2614	COG1136	(ABC) transporter
Clos_2614	COG0577	efflux transmembrane transporter activity
Clos_2616	COG1136	(ABC) transporter
Clos_2619	COG1136	(ABC) transporter
Clos_2623	COG4974	Belongs to the 'phage' integrase family
Clos_2625	COG3328	transposase activity
Clos_2628	COG2373	Large extracellular alpha-helical protein
Clos_2629	COG2208	phosphoserine phosphatase activity
Clos_2630	COG0248	Ppx GppA phosphatase
Clos_2631	COG1098	S1 RNA binding domain
Clos_2635	COG2385	sporulation resulting in formation of a cellular spore
Clos_2636	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Clos_2637	COG0776	regulation of translation
Clos_2638	COG3956	TIGRFAM MazG family protein
Clos_2639	COG2244	polysaccharide biosynthetic process
Clos_2640	COG2002	toxin-antitoxin pair type II binding
Clos_2641	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Clos_2642	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Clos_2644	COG0193	aminoacyl-tRNA hydrolase activity
Clos_2646	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Clos_2647	COG2088	sporulation resulting in formation of a cellular spore
Clos_2648	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Clos_2649	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Clos_2650	COG1316	TRANSCRIPTIONal
Clos_2651	COG1305	Transglutaminase-like
Clos_2653	COG0714	Associated with various cellular activities
Clos_2654	COG2195	Cleaves the N-terminal amino acid of tripeptides
Clos_2655	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Clos_2657	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Clos_2658	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Clos_2659	COG3584	3D domain protein
Clos_2659	COG3583	domain protein
Clos_2661	COG0084	hydrolase, TatD family'
Clos_2662	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_2662	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Clos_2664	COG0700	Nucleoside recognition
Clos_2665	COG2715	membrane protein required for spore maturation
Clos_2666	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Clos_2667	COG2002	toxin-antitoxin pair type II binding
Clos_2668	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Clos_2669	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Clos_2673	COG1191	sigma factor activity
Clos_2674	COG1757	Na H antiporter
Clos_2677	COG1132	(ABC) transporter
Clos_2680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Clos_2681	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Clos_2682	COG0765	amino acid transport
Clos_2688	COG1882	Formate acetyltransferase
Clos_2689	COG1802	Transcriptional regulator
Clos_2690	COG3976	FMN-binding domain protein
Clos_2690	COG1053	succinate dehydrogenase
Clos_2690	COG0431	NADPH-dependent FMN reductase
Clos_2693	COG0352	thiamine-phosphate diphosphorylase activity
Clos_2694	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Clos_2695	COG0351	phosphomethylpyrimidine kinase
Clos_2696	COG1028	Short-chain dehydrogenase reductase Sdr
Clos_2698	COG1114	Component of the transport system for branched-chain amino acids
Clos_2699	COG1193	negative regulation of DNA recombination
Clos_2700	COG2205	protein histidine kinase activity
Clos_2703	COG4120	Belongs to the binding-protein-dependent transport system permease family
Clos_2706	COG0697	spore germination
Clos_2708	COG1489	DNA binding
Clos_2709	COG1671	Belongs to the UPF0178 family
Clos_2710	COG1053	succinate dehydrogenase
Clos_2711	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Clos_2712	COG0039	L-malate dehydrogenase activity
Clos_2716	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Clos_2717	COG0785	Cytochrome C biogenesis protein
Clos_2718	COG0697	spore germination
Clos_2724	COG2832	Protein of unknown function (DUF454)
Clos_2728	COG0519	Catalyzes the synthesis of GMP from XMP
Clos_2729	COG0456	acetyltransferase
Clos_2730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Clos_2732	COG1522	sequence-specific DNA binding
Clos_2733	COG3844	kynureninase activity
Clos_2734	COG2824	Alkylphosphonate utilization operon protein PhnA
Clos_2737	COG0346	lactoylglutathione lyase activity
Clos_2739	COG1757	Na H antiporter
Clos_2740	COG0018	arginyl-trna synthetase
Clos_2741	COG1011	Hydrolase
Clos_2742	COG1115	amino acid carrier protein
Clos_2743	COG0024	Methionine aminopeptidase
Clos_2745	COG3708	Transcriptional regulator
Clos_2745	COG2207	Transcriptional regulator
Clos_2747	COG0697	spore germination
Clos_2748	COG2207	Transcriptional regulator
Clos_2749	COG0778	Nitroreductase
Clos_2751	COG1131	(ABC) transporter
Clos_2752	COG0789	Transcriptional regulator
Clos_2758	COG1307	EDD domain protein, DegV family
Clos_2759	COG0454	-acetyltransferase
Clos_2759	COG0456	acetyltransferase
Clos_2761	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Clos_2762	COG1357	PFAM Pentapeptide repeats (8 copies)
Clos_2765	COG2226	methyltransferase
Clos_2771	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Clos_2774	COG0508	dehydrogenase complex catalyzes the overall conversion of
Clos_2774	COG0596	Alpha beta hydrolase
Clos_2775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Clos_2777	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Clos_2778	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Clos_2783	COG5002	protein histidine kinase activity
Clos_2784	COG0745	RESPONSE REGULATOR receiver
Clos_2786	COG1404	Belongs to the peptidase S8 family
Clos_2787	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Clos_2788	COG3706	GGDEF domain
Clos_2790	COG3279	Response regulator of the LytR AlgR family
Clos_2791	COG0745	RESPONSE REGULATOR receiver
Clos_2791	COG2972	Histidine kinase
Clos_2792	COG4942	peptidase
Clos_2797	COG0305	Participates in initiation and elongation during chromosome replication
Clos_2798	COG0359	binds to the 23S rRNA
Clos_2799	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Clos_2804	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Clos_2805	COG2703	oxygen carrier activity
Clos_2806	COG1592	Rubrerythrin
Clos_2809	COG2819	hydrolase of the alpha beta superfamily
Clos_2810	COG1120	ATPase activity
Clos_2811	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_2812	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Clos_2813	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Clos_2816	COG0726	polysaccharide deacetylase
Clos_2823	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Clos_2826	COG4191	Histidine kinase
Clos_2836	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Clos_2840	COG0494	nUDIX hydrolase
Clos_2844	COG0456	acetyltransferase
Clos_2846	COG2207	Transcriptional regulator
Clos_2846	COG3708	Transcriptional regulator
Clos_2854	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Clos_2855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Clos_2856	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Clos_2860	COG1181	Belongs to the D-alanine--D-alanine ligase family
Clos_2861	COG2720	vancomycin resistance protein
Clos_2864	COG1597	lipid kinase activity
Clos_2866	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Clos_2867	COG1475	DNA binding
Clos_2868	COG1192	Involved in chromosome partitioning
Clos_2870	COG0357	Ribosomal RNA small subunit methyltransferase G
Clos_2871	COG0445	tRNA wobble uridine modification
Clos_2872	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Clos_2873	COG1847	R3H domain protein
Clos_2874	COG0706	membrane insertase activity
Clos_2875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Clos_2876	COG0594	ribonuclease P activity
Clos_2877	COG0230	Belongs to the bacterial ribosomal protein bL34 family