locus-tag	class	description
HYG84_00005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_00015	COG2508	Transcriptional regulator
HYG84_00020	COG2233	PERMEase
HYG84_00040	COG0534	Mate efflux family protein
HYG84_00050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_00055	COG1309	transcriptional regulator
HYG84_00060	COG1214	PFAM Peptidase M22, glycoprotease
HYG84_00060	COG0456	acetyltransferase
HYG84_00065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYG84_00070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_00080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYG84_00090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYG84_00095	COG5012	cobalamin binding
HYG84_00105	COG0484	heat shock protein binding
HYG84_00120	COG2205	protein histidine kinase activity
HYG84_00125	COG0745	RESPONSE REGULATOR receiver
HYG84_00135	COG1136	(ABC) transporter
HYG84_00150	COG1982	Orn Lys Arg decarboxylase major
HYG84_00160	COG2720	vancomycin resistance protein
HYG84_00175	COG3192	ethanolamine utilization protein
HYG84_00180	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG84_00190	COG4869	propanediol catabolic process
HYG84_00205	COG1454	alcohol dehydrogenase
HYG84_00205	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_00225	COG4303	Ethanolamine ammonia lyase large subunit
HYG84_00245	COG2096	Adenosyltransferase
HYG84_00250	COG4917	ethanolamine utilization protein
HYG84_00290	COG1595	DNA-templated transcription, initiation
HYG84_00335	COG2323	membrane
HYG84_00355	COG1187	pseudouridine synthase activity
HYG84_00360	COG1183	phosphatidylcholine synthase activity
HYG84_00365	COG0191	fructose-bisphosphate aldolase activity
HYG84_00375	COG2357	RelA SpoT domain protein
HYG84_00395	COG1242	4 iron, 4 sulfur cluster binding
HYG84_00415	COG1131	(ABC) transporter
HYG84_00420	COG1309	transcriptional regulator
HYG84_00425	COG3693	PFAM glycoside hydrolase, family 10
HYG84_00445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYG84_00455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYG84_00465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYG84_00485	COG1725	Transcriptional regulator
HYG84_00500	COG2310	stress, protein
HYG84_00505	COG2310	stress, protein
HYG84_00520	COG3853	Toxic anion resistance protein (TelA)
HYG84_00540	COG1595	DNA-templated transcription, initiation
HYG84_00545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG84_00560	COG1979	alcohol dehydrogenase
HYG84_00575	COG3973	AAA domain
HYG84_00580	COG0564	pseudouridine synthase activity
HYG84_00585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYG84_00585	COG0116	Belongs to the methyltransferase superfamily
HYG84_00605	COG1649	PFAM Uncharacterised BCR, COG1649
HYG84_00610	COG1132	(ABC) transporter
HYG84_00615	COG1132	(ABC) transporter
HYG84_00625	COG2207	Transcriptional regulator
HYG84_00630	COG1876	peptidase activity
HYG84_00635	COG1773	rubredoxin
HYG84_00640	COG2364	Membrane
HYG84_00670	COG2358	TRAP transporter, solute receptor (TAXI family
HYG84_00680	COG3263	regulation of cellular component size
HYG84_00695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYG84_00700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYG84_00730	COG0596	Alpha beta hydrolase
HYG84_00735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG84_00740	COG2086	electron transfer activity
HYG84_00745	COG1960	acyl-CoA dehydrogenase activity
HYG84_00755	COG0569	domain protein
HYG84_00760	COG0488	(ABC) transporter
HYG84_00765	COG1690	Belongs to the RtcB family
HYG84_00770	COG4536	flavin adenine dinucleotide binding
HYG84_00775	COG0351	phosphomethylpyrimidine kinase
HYG84_00775	COG0352	thiamine-phosphate diphosphorylase activity
HYG84_00780	COG1671	Belongs to the UPF0178 family
HYG84_00785	COG0789	Transcriptional regulator
HYG84_00795	COG1132	(ABC) transporter
HYG84_00815	COG1215	transferase activity, transferring glycosyl groups
HYG84_00820	COG0463	Glycosyl transferase, family 2
HYG84_00825	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_00835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_00840	COG0546	phosphoglycolate phosphatase activity
HYG84_00845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG84_00860	COG1164	Oligoendopeptidase f
HYG84_00875	COG1757	Na H antiporter
HYG84_00880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG84_00895	COG0492	ferredoxin-NADP+ reductase activity
HYG84_00900	COG3118	belongs to the thioredoxin family
HYG84_00915	COG1136	(ABC) transporter
HYG84_00920	COG0577	efflux transmembrane transporter activity
HYG84_00920	COG1136	(ABC) transporter
HYG84_00925	COG0745	RESPONSE REGULATOR receiver
HYG84_00930	COG5002	protein histidine kinase activity
HYG84_00945	COG2233	PERMEase
HYG84_00970	COG1595	DNA-templated transcription, initiation
HYG84_00975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYG84_00985	COG1131	(ABC) transporter
HYG84_01005	COG1131	(ABC) transporter
HYG84_01020	COG0531	amino acid
HYG84_01025	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYG84_01035	COG1595	DNA-templated transcription, initiation
HYG84_01055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HYG84_01060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HYG84_01065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYG84_01075	COG1316	TRANSCRIPTIONal
HYG84_01085	COG0662	Cupin 2, conserved barrel domain protein
HYG84_01115	COG2304	oxidoreductase activity
HYG84_01125	COG0714	Associated with various cellular activities
HYG84_01130	COG4716	Myosin-crossreactive antigen
HYG84_01185	COG0789	Transcriptional regulator
HYG84_01185	COG4978	Transcriptional regulator
HYG84_01205	COG0488	(ABC) transporter
HYG84_01225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYG84_01255	COG5002	protein histidine kinase activity
HYG84_01260	COG0745	RESPONSE REGULATOR receiver
HYG84_01285	COG0653	protein targeting
HYG84_01305	COG5566	PFAM Mor transcription activator
HYG84_01330	COG1131	(ABC) transporter
HYG84_01440	COG4974	Belongs to the 'phage' integrase family
HYG84_01465	COG0824	Thioesterase
HYG84_01475	COG0205	6-phosphofructokinase activity
HYG84_01485	COG0587	DNA-directed DNA polymerase activity
HYG84_01500	COG1136	(ABC) transporter
HYG84_01515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYG84_01520	COG1481	regulation of sporulation
HYG84_01530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYG84_01535	COG1660	Displays ATPase and GTPase activities
HYG84_01540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYG84_01550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG84_01570	COG0322	excinuclease ABC activity
HYG84_01580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG84_01585	COG0556	nucleotide-excision repair
HYG84_01595	COG0793	Belongs to the peptidase S41A family
HYG84_01600	COG0739	heme binding
HYG84_01605	COG2177	Part of the ABC transporter FtsEX involved in
HYG84_01610	COG2884	Cell division ATP-binding protein ftsE
HYG84_01615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYG84_01620	COG3394	polysaccharide catabolic process
HYG84_01625	COG1486	melibiose metabolic process
HYG84_01630	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYG84_01635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYG84_01645	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYG84_01645	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYG84_01660	COG3958	Transketolase
HYG84_01665	COG3959	Transketolase, thiamine diphosphate binding domain
HYG84_01670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_01695	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG84_01715	COG0736	holo-[acyl-carrier-protein] synthase activity
HYG84_01730	COG4608	Belongs to the ABC transporter superfamily
HYG84_01735	COG0444	Belongs to the ABC transporter superfamily
HYG84_01740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_01745	COG0601	transmembrane transport
HYG84_01750	COG4166	transmembrane transport
HYG84_01760	COG1132	(ABC) transporter
HYG84_01765	COG0747	negative chemotaxis
HYG84_01770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYG84_01820	COG0745	RESPONSE REGULATOR receiver
HYG84_01825	COG2205	protein histidine kinase activity
HYG84_01845	COG3344	reverse transcriptase
HYG84_01850	COG0747	negative chemotaxis
HYG84_01855	COG0384	phenazine biosynthesis protein PhzF
HYG84_01865	COG0726	polysaccharide deacetylase
HYG84_01870	COG0419	ATPase involved in DNA repair
HYG84_01875	COG0420	3'-5' exonuclease activity
HYG84_01880	COG1074	ATP-dependent DNA helicase activity
HYG84_01885	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HYG84_01895	COG0642	Histidine kinase
HYG84_01905	COG1132	(ABC) transporter
HYG84_01910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_01935	COG0642	Histidine kinase
HYG84_01940	COG0745	RESPONSE REGULATOR receiver
HYG84_01960	COG4868	Belongs to the UPF0371 family
HYG84_01970	COG1994	Peptidase M50
HYG84_01975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_01985	COG1363	Peptidase, m42
HYG84_01995	COG0708	Exodeoxyribonuclease III
HYG84_02000	COG1533	DNA photolyase activity
HYG84_02005	COG3708	Transcriptional regulator
HYG84_02005	COG2207	Transcriptional regulator
HYG84_02010	COG2226	methyltransferase
HYG84_02040	COG1846	Transcriptional regulator
HYG84_02045	COG0604	alcohol dehydrogenase
HYG84_02055	COG1794	racemase activity, acting on amino acids and derivatives
HYG84_02065	COG3829	transcription factor binding
HYG84_02070	COG5002	protein histidine kinase activity
HYG84_02075	COG0745	RESPONSE REGULATOR receiver
HYG84_02110	COG1592	Rubrerythrin
HYG84_02115	COG0363	glucosamine-6-phosphate deaminase activity
HYG84_02125	COG1737	Transcriptional regulator
HYG84_02135	COG1263	PTS System
HYG84_02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG84_02145	COG0688	phosphatidylethanolamine metabolic process
HYG84_02155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYG84_02160	COG0167	dihydroorotate dehydrogenase activity
HYG84_02165	COG0543	2 iron, 2 sulfur cluster binding
HYG84_02170	COG0284	orotidine-5'-phosphate decarboxylase activity
HYG84_02175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYG84_02185	COG1408	metallophosphoesterase
HYG84_02195	COG2070	2-Nitropropane dioxygenase
HYG84_02220	COG2274	protein secretion by the type I secretion system
HYG84_02225	COG0017	Asparaginyl-tRNA synthetase
HYG84_02235	COG0726	polysaccharide deacetylase
HYG84_02240	COG2508	Transcriptional regulator
HYG84_02245	COG0549	Belongs to the carbamate kinase family
HYG84_02250	COG1301	dicarboxylic acid transport
HYG84_02260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_02265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_02270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HYG84_02275	COG3257	ureidoglycine aminohydrolase activity
HYG84_02280	COG2271	Major facilitator Superfamily
HYG84_02285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_02300	COG0534	Mate efflux family protein
HYG84_02305	COG0772	Belongs to the SEDS family
HYG84_02310	COG1695	Transcriptional regulator
HYG84_02325	COG2814	Major facilitator Superfamily
HYG84_02345	COG1704	LemA family
HYG84_02360	COG1595	DNA-templated transcription, initiation
HYG84_02365	COG0011	TIGRFAM Protein of
HYG84_02380	COG1131	(ABC) transporter
HYG84_02385	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYG84_02395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYG84_02400	COG3829	transcription factor binding
HYG84_02400	COG3290	protein histidine kinase activity
HYG84_02410	COG1333	cytochrome c biogenesis protein
HYG84_02420	COG0577	efflux transmembrane transporter activity
HYG84_02425	COG1136	(ABC) transporter
HYG84_02430	COG5002	protein histidine kinase activity
HYG84_02435	COG0745	RESPONSE REGULATOR receiver
HYG84_02455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYG84_02460	COG2056	Na+-H+ antiporter family
HYG84_02465	COG1472	Belongs to the glycosyl hydrolase 3 family
HYG84_02470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HYG84_02480	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_02485	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG84_02490	COG3845	ABC transporter
HYG84_02495	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_02510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYG84_02525	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_02540	COG3426	butyrate kinase activity
HYG84_02545	COG0280	phosphate acetyltransferase
HYG84_02550	COG3290	protein histidine kinase activity
HYG84_02550	COG3829	transcription factor binding
HYG84_02560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYG84_02570	COG5322	oxidoreductase activity
HYG84_02570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG84_02855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HYG84_02865	COG2323	membrane
HYG84_02870	COG1968	undecaprenyl-diphosphatase activity
HYG84_02875	COG4536	flavin adenine dinucleotide binding
HYG84_02880	COG1376	ErfK ybiS ycfS ynhG family protein
HYG84_02895	COG4149	molybdate abc transporter
HYG84_02900	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYG84_02915	COG3409	Peptidoglycan-binding domain 1 protein
HYG84_02915	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYG84_02945	COG3299	homolog of phage Mu protein gp47
HYG84_02965	COG2823	Periplasmic or secreted lipoprotein
HYG84_02965	COG1652	LysM domain
HYG84_03010	COG1396	sequence-specific DNA binding
HYG84_03010	COG1917	Cupin 2, conserved barrel domain protein
HYG84_03065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYG84_03075	COG3645	SOS response
HYG84_03090	COG4974	Belongs to the 'phage' integrase family
HYG84_03095	COG0459	protein refolding
HYG84_03100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYG84_03105	COG1811	Na channel or pump
HYG84_03135	COG1131	(ABC) transporter
HYG84_03140	COG1346	cytolysis
HYG84_03160	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG84_03175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYG84_03180	COG0488	(ABC) transporter
HYG84_03185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG84_03195	COG0456	acetyltransferase
HYG84_03200	COG1214	PFAM Peptidase M22, glycoprotease
HYG84_03205	COG0802	atpase or kinase
HYG84_03210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYG84_03225	COG2183	response to ionizing radiation
HYG84_03235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_03255	COG0840	transmembrane signaling receptor activity
HYG84_03265	COG0653	protein targeting
HYG84_03275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG84_03275	COG2199	diguanylate cyclase activity
HYG84_03285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYG84_03295	COG1516	flagellar protein fliS
HYG84_03300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYG84_03315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYG84_03320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HYG84_03325	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYG84_03330	COG3829	transcription factor binding
HYG84_03335	COG1757	Na H antiporter
HYG84_03355	COG1773	rubredoxin
HYG84_03355	COG1592	Rubrerythrin
HYG84_03365	COG0346	lactoylglutathione lyase activity
HYG84_03395	COG0457	Tetratricopeptide repeat
HYG84_03395	COG0463	Glycosyl transferase, family 2
HYG84_03400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_03410	COG4786	Flagellar basal body rod
HYG84_03410	COG1256	bacterial-type flagellum assembly
HYG84_03430	COG1040	competence protein
HYG84_03435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG84_03460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYG84_03495	COG3906	Belongs to the UPF0473 family
HYG84_03505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYG84_03515	COG0671	phosphoesterase, PA-phosphatase related
HYG84_03520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYG84_03525	COG1177	transmembrane transport
HYG84_03530	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYG84_03535	COG3842	ATPase activity
HYG84_03540	COG5577	PFAM Coat F domain
HYG84_03545	COG0281	malic enzyme
HYG84_03550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYG84_03555	COG1486	melibiose metabolic process
HYG84_03560	COG1737	Transcriptional regulator
HYG84_03565	COG1263	PTS System
HYG84_03565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYG84_03580	COG2610	gluconate transmembrane transporter activity
HYG84_03585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYG84_03590	COG3395	kinase activity
HYG84_03595	COG1349	DNA-binding transcription factor activity
HYG84_03600	COG1376	ErfK ybiS ycfS ynhG family protein
HYG84_03610	COG3951	Flagellar rod assembly protein muramidase FlgJ
HYG84_03610	COG1705	Flagellar rod assembly protein muramidase FlgJ
HYG84_03630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG84_03675	COG0438	transferase activity, transferring glycosyl groups
HYG84_03685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYG84_03690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYG84_03700	COG3693	PFAM glycoside hydrolase, family 10
HYG84_03705	COG3693	PFAM glycoside hydrolase, family 10
HYG84_03710	COG4464	protein tyrosine phosphatase activity
HYG84_03715	COG0489	protein tyrosine kinase activity
HYG84_03720	COG3944	biosynthesis protein
HYG84_03735	COG4786	Flagellar basal body rod
HYG84_03740	COG1077	Cell shape determining protein MreB Mrl
HYG84_03745	COG1609	Transcriptional regulator
HYG84_03755	COG2385	sporulation resulting in formation of a cellular spore
HYG84_03760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG84_03780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYG84_03785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYG84_03790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYG84_03795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYG84_03800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG84_03805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYG84_03810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYG84_03830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYG84_03835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG84_03840	COG2131	deaminase
HYG84_03845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYG84_03850	COG0698	ribose 5-phosphate isomerase
HYG84_03855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYG84_03860	COG4608	Belongs to the ABC transporter superfamily
HYG84_03865	COG0444	Belongs to the ABC transporter superfamily
HYG84_03870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_03875	COG0601	transmembrane transport
HYG84_03880	COG0747	negative chemotaxis
HYG84_03885	COG2362	D-Aminopeptidase
HYG84_03890	COG0009	L-threonylcarbamoyladenylate synthase
HYG84_03895	COG0768	penicillin binding
HYG84_03910	COG0428	transporter
HYG84_03915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYG84_03920	COG2890	protein-(glutamine-N5) methyltransferase activity
HYG84_03925	COG3872	metal-dependent enzyme
HYG84_03930	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG84_03945	COG1131	(ABC) transporter
HYG84_03955	COG2197	response regulator
HYG84_03960	COG4585	Histidine kinase
HYG84_03965	COG0495	leucyl-tRNA aminoacylation
HYG84_03970	COG1435	thymidine kinase activity
HYG84_03975	COG0254	rRNA binding
HYG84_03980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYG84_03985	COG1126	abc transporter atp-binding protein
HYG84_03990	COG0765	amino acid transport
HYG84_03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_04000	COG1494	fructose-1,6-bisphosphatase
HYG84_04005	COG1494	fructose-1,6-bisphosphatase
HYG84_04015	COG1122	ATPase activity
HYG84_04030	COG0310	cobalt ion transport
HYG84_04035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYG84_04040	COG3246	L-lysine catabolic process to acetate
HYG84_04045	COG1607	acyl-coa hydrolase
HYG84_04050	COG0733	neurotransmitter:sodium symporter activity
HYG84_04055	COG0733	neurotransmitter:sodium symporter activity
HYG84_04060	COG1361	Conserved repeat domain
HYG84_04065	COG2373	Large extracellular alpha-helical protein
HYG84_04090	COG0728	peptidoglycan biosynthetic process
HYG84_04095	COG1368	sulfuric ester hydrolase activity
HYG84_04100	COG1032	radical SAM domain protein
HYG84_04105	COG1309	transcriptional regulator
HYG84_04115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_04120	COG0577	efflux transmembrane transporter activity
HYG84_04120	COG1136	(ABC) transporter
HYG84_04130	COG1136	(ABC) transporter
HYG84_04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_04155	COG1309	transcriptional regulator
HYG84_04180	COG2373	Large extracellular alpha-helical protein
HYG84_04185	COG2208	phosphoserine phosphatase activity
HYG84_04195	COG1098	S1 RNA binding domain
HYG84_04215	COG2385	sporulation resulting in formation of a cellular spore
HYG84_04220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYG84_04225	COG0776	regulation of translation
HYG84_04230	COG3956	TIGRFAM MazG family protein
HYG84_04235	COG2244	polysaccharide biosynthetic process
HYG84_04240	COG2002	toxin-antitoxin pair type II binding
HYG84_04245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG84_04250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYG84_04260	COG0193	aminoacyl-tRNA hydrolase activity
HYG84_04270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYG84_04275	COG2088	sporulation resulting in formation of a cellular spore
HYG84_04280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG84_04285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYG84_04295	COG1982	Orn Lys Arg decarboxylase major
HYG84_04300	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG84_04305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYG84_04315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYG84_04320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYG84_04325	COG3584	3D domain protein
HYG84_04325	COG3583	domain protein
HYG84_04340	COG1131	(ABC) transporter
HYG84_04345	COG1725	Transcriptional regulator
HYG84_04355	COG0084	hydrolase, TatD family'
HYG84_04360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_04360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_04370	COG0700	Nucleoside recognition
HYG84_04375	COG2715	membrane protein required for spore maturation
HYG84_04380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYG84_04385	COG2002	toxin-antitoxin pair type II binding
HYG84_04390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYG84_04395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYG84_04405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYG84_04410	COG1191	sigma factor activity
HYG84_04420	COG1757	Na H antiporter
HYG84_04430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG84_04450	COG1132	(ABC) transporter
HYG84_04500	COG0352	thiamine-phosphate diphosphorylase activity
HYG84_04505	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYG84_04510	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_04520	COG1193	negative regulation of DNA recombination
HYG84_04525	COG5002	protein histidine kinase activity
HYG84_04535	COG0733	neurotransmitter:sodium symporter activity
HYG84_04550	COG0697	spore germination
HYG84_04570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG84_04575	COG0785	Cytochrome C biogenesis protein
HYG84_04595	COG1309	transcriptional regulator
HYG84_04600	COG1522	sequence-specific DNA binding
HYG84_04605	COG3844	kynureninase activity
HYG84_04610	COG2378	regulation of single-species biofilm formation
HYG84_04625	COG1011	Hydrolase
HYG84_04650	COG0697	spore germination
HYG84_04655	COG4977	sequence-specific DNA binding
HYG84_04660	COG3655	Transcriptional regulator
HYG84_04670	COG1396	sequence-specific DNA binding
HYG84_04685	COG4566	intracellular signal transduction
HYG84_04690	COG0443	Heat shock 70 kDa protein
HYG84_04715	COG1132	(ABC) transporter
HYG84_04765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYG84_04775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYG84_04780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYG84_04805	COG5002	protein histidine kinase activity
HYG84_04810	COG0745	RESPONSE REGULATOR receiver
HYG84_04820	COG1404	Belongs to the peptidase S8 family
HYG84_04825	COG0739	heme binding
HYG84_04865	COG0305	Participates in initiation and elongation during chromosome replication
HYG84_04870	COG0359	binds to the 23S rRNA
HYG84_04875	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HYG84_04900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYG84_04905	COG2703	oxygen carrier activity
HYG84_04910	COG1592	Rubrerythrin
HYG84_04920	COG1686	Belongs to the peptidase S11 family
HYG84_04940	COG4555	ABC transporter
HYG84_04955	COG0840	transmembrane signaling receptor activity
HYG84_04960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYG84_04990	COG5001	Diguanylate cyclase
HYG84_05000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_05015	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_05025	COG3845	ABC transporter
HYG84_05030	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_05040	COG0456	acetyltransferase
HYG84_05055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYG84_05065	COG0280	phosphate acetyltransferase
HYG84_05070	COG0531	amino acid
HYG84_05075	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_05080	COG0471	metal ion transport
HYG84_05085	COG3829	transcription factor binding
HYG84_05085	COG3290	protein histidine kinase activity
HYG84_05095	COG0406	alpha-ribazole phosphatase activity
HYG84_05100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYG84_05105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYG84_05110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG84_05120	COG3949	Membrane
HYG84_05130	COG5002	protein histidine kinase activity
HYG84_05145	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_05150	COG2720	vancomycin resistance protein
HYG84_05160	COG1597	lipid kinase activity
HYG84_05175	COG1475	DNA binding
HYG84_05180	COG1192	Involved in chromosome partitioning
HYG84_05185	COG2119	membrane
HYG84_05195	COG0357	Ribosomal RNA small subunit methyltransferase G
HYG84_05200	COG0445	tRNA wobble uridine modification
HYG84_05205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG84_05210	COG1847	R3H domain protein
HYG84_05215	COG0706	membrane insertase activity
HYG84_05220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYG84_05225	COG0594	ribonuclease P activity
HYG84_05230	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYG84_05235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYG84_05240	COG0592	DNA-directed DNA polymerase activity
HYG84_05250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYG84_05260	COG0187	DNA topoisomerase II activity
HYG84_05265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG84_05275	COG2172	sigma factor antagonist activity
HYG84_05280	COG1191	sigma factor activity
HYG84_05315	COG1573	uracil-dna glycosylase
HYG84_05335	COG0280	phosphate acetyltransferase
HYG84_05370	COG0840	transmembrane signaling receptor activity
HYG84_05395	COG1827	regulation of RNA biosynthetic process
HYG84_05410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYG84_05420	COG0783	Belongs to the Dps family
HYG84_05435	COG0840	transmembrane signaling receptor activity
HYG84_05465	COG0590	tRNA wobble adenosine to inosine editing
HYG84_05480	COG0095	Lipoate-protein ligase
HYG84_05495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYG84_05500	COG0022	dehydrogenase e1 component
HYG84_05510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG84_05520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYG84_05520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG84_05525	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYG84_05545	COG0425	Belongs to the sulfur carrier protein TusA family
HYG84_05555	COG0668	transmembrane transport
HYG84_05565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_05570	COG3290	protein histidine kinase activity
HYG84_05570	COG3829	transcription factor binding
HYG84_05580	COG0252	asparaginase activity
HYG84_05580	COG5275	peptidyl-tyrosine sulfation
HYG84_05595	COG0252	asparaginase activity
HYG84_05595	COG5275	peptidyl-tyrosine sulfation
HYG84_05600	COG0252	asparaginase activity
HYG84_05600	COG5275	peptidyl-tyrosine sulfation
HYG84_05615	COG0360	Binds together with S18 to 16S ribosomal RNA
HYG84_05625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYG84_05640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG84_05645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYG84_05665	COG0840	transmembrane signaling receptor activity
HYG84_05670	COG1937	Protein conserved in bacteria
HYG84_05690	COG3764	Sortase (surface protein transpeptidase)
HYG84_05740	COG1357	PFAM Pentapeptide repeats (8 copies)
HYG84_05745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYG84_05765	COG4124	Belongs to the glycosyl hydrolase 26 family
HYG84_05765	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HYG84_05775	COG1696	Membrane protein involved in D-alanine export
HYG84_05780	COG0398	Pfam SNARE associated Golgi protein
HYG84_05800	COG1982	Orn Lys Arg decarboxylase major
HYG84_05805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_05810	COG3870	Protein conserved in bacteria
HYG84_05820	COG1774	PSP1 C-terminal conserved region
HYG84_05825	COG2221	Nitrite and sulphite reductase 4Fe-4S
HYG84_05830	COG0493	'glutamate synthase
HYG84_05835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYG84_05840	COG0509	glycine decarboxylation via glycine cleavage system
HYG84_05845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG84_05850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYG84_05865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYG84_05870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG84_05870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYG84_05895	COG3426	butyrate kinase activity
HYG84_05900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_05910	COG1136	(ABC) transporter
HYG84_05915	COG0577	efflux transmembrane transporter activity
HYG84_05920	COG5002	protein histidine kinase activity
HYG84_05925	COG0745	RESPONSE REGULATOR receiver
HYG84_05930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_05965	COG5002	protein histidine kinase activity
HYG84_05980	COG0488	(ABC) transporter
HYG84_06020	COG0789	Transcriptional regulator
HYG84_06040	COG2226	methyltransferase
HYG84_06060	COG3708	Transcriptional regulator
HYG84_06060	COG2207	Transcriptional regulator
HYG84_06075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYG84_06080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYG84_06085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYG84_06090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYG84_06140	COG0488	(ABC) transporter
HYG84_06145	COG4555	ABC transporter
HYG84_06155	COG0542	response to heat
HYG84_06175	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_06210	COG3850	Histidine kinase
HYG84_06210	COG5002	protein histidine kinase activity
HYG84_06270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_06275	COG1136	(ABC) transporter
HYG84_06280	COG0577	efflux transmembrane transporter activity
HYG84_06300	COG1024	Enoyl-CoA hydratase
HYG84_06305	COG2610	gluconate transmembrane transporter activity
HYG84_06320	COG2086	electron transfer activity
HYG84_06325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYG84_06330	COG3290	protein histidine kinase activity
HYG84_06330	COG3829	transcription factor binding
HYG84_06345	COG1696	Membrane protein involved in D-alanine export
HYG84_06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG84_06360	COG0723	plastoquinol--plastocyanin reductase activity
HYG84_06405	COG0534	Mate efflux family protein
HYG84_06410	COG1053	succinate dehydrogenase
HYG84_06410	COG3976	FMN-binding domain protein
HYG84_06415	COG2972	Histidine kinase
HYG84_06420	COG3279	Response regulator of the LytR AlgR family
HYG84_06430	COG0739	heme binding
HYG84_06435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_06440	COG0765	amino acid transport
HYG84_06445	COG1126	abc transporter atp-binding protein
HYG84_06450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYG84_06455	COG1687	branched-chain amino acid
HYG84_06460	COG1307	EDD domain protein, DegV family
HYG84_06495	COG3275	phosphorelay sensor kinase activity
HYG84_06545	COG1454	alcohol dehydrogenase
HYG84_06545	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_06550	COG1882	Formate acetyltransferase
HYG84_06555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_06585	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HYG84_06590	COG4656	Part of a membrane complex involved in electron transport
HYG84_06610	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_06610	COG1454	alcohol dehydrogenase
HYG84_06615	COG4869	propanediol catabolic process
HYG84_06625	COG0840	transmembrane signaling receptor activity
HYG84_06635	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HYG84_06655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG84_06695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYG84_06705	COG1757	Na H antiporter
HYG84_06725	COG1132	(ABC) transporter
HYG84_06745	COG3290	protein histidine kinase activity
HYG84_06750	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_06750	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_06750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_06750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYG84_06755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG84_06760	COG2033	superoxide reductase activity
HYG84_06770	COG0840	transmembrane signaling receptor activity
HYG84_06775	COG0653	protein targeting
HYG84_06785	COG0534	Mate efflux family protein
HYG84_06805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYG84_06810	COG0840	transmembrane signaling receptor activity
HYG84_06845	COG0628	permease
HYG84_06850	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_06855	COG0183	Belongs to the thiolase family
HYG84_06860	COG0697	spore germination
HYG84_06885	COG1396	sequence-specific DNA binding
HYG84_06890	COG0697	spore germination
HYG84_06895	COG2068	MobA-Related Protein
HYG84_06935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYG84_06940	COG0573	inorganic phosphate transmembrane transporter activity
HYG84_06945	COG0581	inorganic phosphate transmembrane transporter activity
HYG84_06950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG84_06955	COG0704	Plays a role in the regulation of phosphate uptake
HYG84_06970	COG0719	Fe-S assembly protein
HYG84_06975	COG0719	Fe-S assembly protein
HYG84_06980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYG84_06985	COG0822	iron-sulfur transferase activity
HYG84_06995	COG1757	Na H antiporter
HYG84_07000	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYG84_07015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYG84_07030	COG2385	sporulation resulting in formation of a cellular spore
HYG84_07035	COG4466	Protein conserved in bacteria
HYG84_07045	COG4187	Peptidase family M20/M25/M40
HYG84_07070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYG84_07075	COG1802	Transcriptional regulator
HYG84_07100	COG0697	spore germination
HYG84_07105	COG0814	amino acid
HYG84_07125	COG5505	Protein of unknown function (DUF819)
HYG84_07135	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_07155	COG0840	transmembrane signaling receptor activity
HYG84_07160	COG0534	Mate efflux family protein
HYG84_07165	COG1609	Transcriptional regulator
HYG84_07195	COG2378	regulation of single-species biofilm formation
HYG84_07210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_07215	COG1473	amidohydrolase
HYG84_07220	COG2508	Transcriptional regulator
HYG84_07230	COG0456	acetyltransferase
HYG84_07240	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYG84_07245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG84_07250	COG1794	racemase activity, acting on amino acids and derivatives
HYG84_07270	COG0840	transmembrane signaling receptor activity
HYG84_07275	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYG84_07280	COG2205	protein histidine kinase activity
HYG84_07280	COG2770	Histidine kinase
HYG84_07285	COG0745	RESPONSE REGULATOR receiver
HYG84_07295	COG3384	dioxygenase
HYG84_07310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYG84_07315	COG0589	response to stress
HYG84_07315	COG0475	glutathione-regulated potassium exporter activity
HYG84_07365	COG0745	RESPONSE REGULATOR receiver
HYG84_07370	COG5002	protein histidine kinase activity
HYG84_07380	COG1803	Methylglyoxal synthase
HYG84_07390	COG0534	Mate efflux family protein
HYG84_07405	COG0322	excinuclease ABC activity
HYG84_07415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HYG84_07430	COG1335	isochorismatase
HYG84_07435	COG0163	prenyltransferase activity
HYG84_07455	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HYG84_07475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_07480	COG2252	PERMEase
HYG84_07485	COG0402	S-adenosylhomocysteine deaminase activity
HYG84_07510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_07520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYG84_07525	COG0840	transmembrane signaling receptor activity
HYG84_07530	COG1272	protein, Hemolysin III
HYG84_07540	COG0511	ligase activity, forming carbon-carbon bonds
HYG84_07545	COG0439	Biotin carboxylase
HYG84_07550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYG84_07555	COG0825	malonyl-CoA metabolic process
HYG84_07560	COG0789	Transcriptional regulator
HYG84_07565	COG1131	(ABC) transporter
HYG84_07595	COG2207	Transcriptional regulator
HYG84_07595	COG4753	response regulator
HYG84_07600	COG2972	Histidine kinase
HYG84_07605	COG3976	FMN-binding domain protein
HYG84_07605	COG1053	succinate dehydrogenase
HYG84_07615	COG1902	pentaerythritol trinitrate reductase activity
HYG84_07630	COG0019	diaminopimelate decarboxylase activity
HYG84_07635	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG84_07640	COG1473	amidohydrolase
HYG84_07660	COG2210	Belongs to the sulfur carrier protein TusA family
HYG84_07675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYG84_07685	COG1388	LysM domain
HYG84_07685	COG3858	chitin binding
HYG84_07690	COG0116	Belongs to the methyltransferase superfamily
HYG84_07705	COG4948	Mandelate Racemase Muconate Lactonizing
HYG84_07715	COG3829	transcription factor binding
HYG84_07720	COG0604	alcohol dehydrogenase
HYG84_07735	COG1193	negative regulation of DNA recombination
HYG84_07740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG84_07745	COG5012	cobalamin binding
HYG84_07760	COG3279	Response regulator of the LytR AlgR family
HYG84_07785	COG2304	oxidoreductase activity
HYG84_07795	COG0037	tRNA processing
HYG84_07800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_07805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_07805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_07810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_07810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYG84_07820	COG0346	lactoylglutathione lyase activity
HYG84_07825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYG84_07835	COG4770	biotin carboxylase activity
HYG84_07840	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HYG84_07845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HYG84_07845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HYG84_07855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYG84_07860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYG84_07870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYG84_07875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYG84_07900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYG84_07905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG84_07910	COG3880	PFAM UvrB UvrC protein
HYG84_07915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYG84_07920	COG0542	response to heat
HYG84_07930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYG84_07945	COG1329	Transcriptional regulator
HYG84_07950	COG4956	integral membrane protein (PIN domain superfamily)
HYG84_07955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYG84_07960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYG84_07965	COG4555	ABC transporter
HYG84_07970	COG1668	transmembrane transport
HYG84_07975	COG0442	prolyl-tRNA aminoacylation
HYG84_07985	COG0745	RESPONSE REGULATOR receiver
HYG84_07990	COG2205	protein histidine kinase activity
HYG84_07995	COG4086	secreted protein
HYG84_08000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYG84_08005	COG1045	serine acetyltransferase
HYG84_08010	COG0215	cysteine-tRNA ligase activity
HYG84_08030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG84_08035	COG3688	RNA-binding protein containing a PIN domain
HYG84_08045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG84_08050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYG84_08060	COG0250	Participates in transcription elongation, termination and antitermination
HYG84_08065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYG84_08070	COG0081	regulation of translation
HYG84_08075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYG84_08080	COG0222	ribosome binding
HYG84_08085	COG0085	RNA polymerase activity
HYG84_08090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYG84_08095	COG1358	cellular component organization or biogenesis
HYG84_08100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYG84_08105	COG0049	tRNA binding
HYG84_08110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYG84_08115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYG84_08120	COG0051	transcription antitermination factor activity, RNA binding
HYG84_08125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYG84_08130	COG0088	Forms part of the polypeptide exit tunnel
HYG84_08135	COG0089	rRNA binding
HYG84_08140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYG84_08145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYG84_08150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYG84_08155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYG84_08160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYG84_08165	COG0255	Belongs to the universal ribosomal protein uL29 family
HYG84_08170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYG84_08175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYG84_08180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYG84_08185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYG84_08190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYG84_08195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYG84_08200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYG84_08205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYG84_08210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYG84_08215	COG1841	ribosomal large subunit assembly
HYG84_08220	COG0200	Binds to the 23S rRNA
HYG84_08225	COG0201	protein transport
HYG84_08230	COG0563	adenylate kinase activity
HYG84_08235	COG0024	Methionine aminopeptidase
HYG84_08245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYG84_08250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYG84_08255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYG84_08260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYG84_08265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG84_08270	COG0202	RNA polymerase activity
HYG84_08275	COG0203	ribosomal protein L17
HYG84_08280	COG1122	ATPase activity
HYG84_08290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYG84_08295	COG0101	tRNA pseudouridine synthase activity
HYG84_08300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYG84_08305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYG84_08320	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_08335	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_08355	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HYG84_08365	COG0243	molybdopterin cofactor binding
HYG84_08370	COG0437	4 iron, 4 sulfur cluster binding
HYG84_08380	COG5577	PFAM Coat F domain
HYG84_08395	COG0516	GMP reductase activity
HYG84_08395	COG0517	IMP dehydrogenase activity
HYG84_08400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYG84_08400	COG0519	Catalyzes the synthesis of GMP from XMP
HYG84_08405	COG3655	Transcriptional regulator
HYG84_08410	COG2252	PERMEase
HYG84_08415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYG84_08420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYG84_08425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYG84_08430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYG84_08435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYG84_08440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYG84_08445	COG0138	bifunctional purine biosynthesis protein purh
HYG84_08450	COG0151	Belongs to the GarS family
HYG84_08460	COG0840	transmembrane signaling receptor activity
HYG84_08470	COG2011	ABC-type metal ion transport system permease component
HYG84_08475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYG84_08480	COG0527	aspartate kinase activity
HYG84_08485	COG1114	Component of the transport system for branched-chain amino acids
HYG84_08490	COG1301	dicarboxylic acid transport
HYG84_08495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_08500	COG0210	DNA helicase
HYG84_08505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG84_08515	COG1592	Rubrerythrin
HYG84_08520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYG84_08525	COG0154	amidase activity
HYG84_08530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYG84_08540	COG3069	C4-dicarboxylate transmembrane transporter activity
HYG84_08565	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG84_08575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYG84_08660	COG4824	toxin secretion phage lysis holin
HYG84_08720	COG2984	ABC transporter substrate binding protein
HYG84_08725	COG3852	Histidine kinase
HYG84_08730	COG2204	response regulator
HYG84_08755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_08760	COG0746	molybdenum cofactor guanylyltransferase activity
HYG84_08765	COG0303	'Molybdopterin
HYG84_08785	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_08790	COG3192	ethanolamine utilization protein
HYG84_08800	COG1492	cobalamin metabolic process
HYG84_08810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYG84_08820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_08825	COG1120	ATPase activity
HYG84_08830	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYG84_08835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYG84_08840	COG0406	alpha-ribazole phosphatase activity
HYG84_08860	COG0840	transmembrane signaling receptor activity
HYG84_08890	COG2715	membrane protein required for spore maturation
HYG84_08895	COG0700	Nucleoside recognition
HYG84_08900	COG0531	amino acid
HYG84_08910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYG84_08915	COG2323	membrane
HYG84_08920	COG0697	spore germination
HYG84_08935	COG0531	amino acid
HYG84_08975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYG84_09015	COG1518	maintenance of DNA repeat elements
HYG84_09020	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYG84_09030	COG0617	tRNA 3'-terminal CCA addition
HYG84_09030	COG1353	crispr-associated protein
HYG84_09045	COG1278	Cold shock
HYG84_09050	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYG84_09055	COG0740	serine-type endopeptidase activity
HYG84_09060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG84_09065	COG0470	DNA polymerase III
HYG84_09065	COG1067	ATP-dependent peptidase activity
HYG84_09075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYG84_09080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYG84_09090	COG0427	acetyl-CoA hydrolase
HYG84_09095	COG2985	domain, Protein
HYG84_09100	COG1773	rubredoxin
HYG84_09140	COG2217	Heavy metal translocating P-type atpase
HYG84_09145	COG0549	Belongs to the carbamate kinase family
HYG84_09155	COG0540	Belongs to the ATCase OTCase family
HYG84_09170	COG3706	GGDEF domain
HYG84_09175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYG84_09190	COG1924	4 iron, 4 sulfur cluster binding
HYG84_09195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG84_09195	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG84_09205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_09210	COG0437	4 iron, 4 sulfur cluster binding
HYG84_09215	COG2414	aldehyde ferredoxin oxidoreductase
HYG84_09220	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HYG84_09235	COG0601	transmembrane transport
HYG84_09245	COG0444	Belongs to the ABC transporter superfamily
HYG84_09250	COG4608	Belongs to the ABC transporter superfamily
HYG84_09260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_09270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYG84_09275	COG0805	protein transport
HYG84_09280	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYG84_09280	COG3443	Belongs to the bacterial solute-binding protein 9 family
HYG84_09285	COG1121	(ABC) transporter
HYG84_09290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYG84_09320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYG84_09330	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_09335	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_09335	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_09365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYG84_09380	COG1307	EDD domain protein, DegV family
HYG84_09405	COG2996	Protein conserved in bacteria
HYG84_09410	COG1115	amino acid carrier protein
HYG84_09445	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG84_09450	COG0726	polysaccharide deacetylase
HYG84_09455	COG4242	Belongs to the peptidase S51 family
HYG84_09480	COG0431	NADPH-dependent FMN reductase
HYG84_09480	COG1053	succinate dehydrogenase
HYG84_09480	COG3976	FMN-binding domain protein
HYG84_09505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG84_09510	COG2208	phosphoserine phosphatase activity
HYG84_09515	COG2199	diguanylate cyclase activity
HYG84_09515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYG84_09520	COG3711	transcriptional antiterminator
HYG84_09530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYG84_09535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG84_09555	COG3437	response regulator, receiver
HYG84_09560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYG84_09575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYG84_09620	COG1116	anion transmembrane transporter activity
HYG84_09625	COG5002	protein histidine kinase activity
HYG84_09635	COG0475	glutathione-regulated potassium exporter activity
HYG84_09655	COG0561	phosphatase activity
HYG84_09665	COG0312	modulator of DNA gyrase
HYG84_09670	COG0312	modulator of DNA gyrase
HYG84_09675	COG3872	metal-dependent enzyme
HYG84_09700	COG0772	Belongs to the SEDS family
HYG84_09705	COG2239	Acts as a magnesium transporter
HYG84_09715	COG2959	enzyme of heme biosynthesis
HYG84_09730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYG84_09740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYG84_09745	COG0488	(ABC) transporter
HYG84_09755	COG2244	polysaccharide biosynthetic process
HYG84_09815	COG3615	Tellurite resistance protein tehB
HYG84_09815	COG0500	methyltransferase
HYG84_09905	COG0745	RESPONSE REGULATOR receiver
HYG84_09910	COG5002	protein histidine kinase activity
HYG84_09925	COG3681	Belongs to the UPF0597 family
HYG84_09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYG84_09950	COG0525	valine-tRNA ligase activity
HYG84_09955	COG0285	dihydrofolate synthase activity
HYG84_09995	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYG84_10000	COG0436	Aminotransferase
HYG84_10005	COG0726	polysaccharide deacetylase
HYG84_10020	COG4974	Belongs to the 'phage' integrase family
HYG84_10130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG84_10140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYG84_10145	COG2339	peptidase activity
HYG84_10160	COG0681	Belongs to the peptidase S26 family
HYG84_10165	COG0517	IMP dehydrogenase activity
HYG84_10170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYG84_10175	COG2066	Belongs to the glutaminase family
HYG84_10185	COG2226	methyltransferase
HYG84_10190	COG1278	Cold shock
HYG84_10195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYG84_10225	COG1396	sequence-specific DNA binding
HYG84_10255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_10275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_10290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_10320	COG0456	acetyltransferase
HYG84_10365	COG1819	glycosyl
HYG84_10380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_10385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_10405	COG4399	Belongs to the UPF0754 family
HYG84_10405	COG4399	Belongs to the UPF0754 family
HYG84_10420	COG4619	ABC transporter
HYG84_10425	COG0390	transport system, permease component
HYG84_10440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYG84_10445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYG84_10450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYG84_10455	COG0569	domain protein
HYG84_10460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYG84_10470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYG84_10475	COG0072	phenylalanine-tRNA ligase activity
HYG84_10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_10480	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYG84_10535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_10540	COG0826	peptidase U32
HYG84_10550	COG1666	GTP binding
HYG84_10560	COG1846	Transcriptional regulator
HYG84_10565	COG0534	Mate efflux family protein
HYG84_10590	COG0835	chemotaxis
HYG84_10590	COG0784	Response regulator, receiver
HYG84_10620	COG0170	dolichyl monophosphate biosynthetic process
HYG84_10630	COG2233	PERMEase
HYG84_10635	COG0426	domain, Protein
HYG84_10645	COG1506	peptidase
HYG84_10645	COG4946	Tricorn protease homolog
HYG84_10645	COG0823	Involved in the tonB-independent uptake of proteins
HYG84_10680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYG84_10690	COG1132	(ABC) transporter
HYG84_10695	COG1132	(ABC) transporter
HYG84_10700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_10700	COG2247	cell wall binding repeat
HYG84_10715	COG1058	Belongs to the CinA family
HYG84_10715	COG1546	Belongs to the CinA family
HYG84_10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYG84_10735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYG84_10755	COG1396	sequence-specific DNA binding
HYG84_10780	COG2267	carboxylic ester hydrolase activity
HYG84_10790	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYG84_10800	COG0346	lactoylglutathione lyase activity
HYG84_10805	COG0697	spore germination
HYG84_10810	COG2207	Transcriptional regulator
HYG84_10895	COG0251	oxidation-reduction process
HYG84_11005	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HYG84_11020	COG1595	DNA-templated transcription, initiation
HYG84_11065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYG84_11095	COG1192	Involved in chromosome partitioning
HYG84_11100	COG1475	DNA binding
HYG84_11155	COG0629	single-stranded DNA binding
HYG84_11240	COG1396	sequence-specific DNA binding
HYG84_11265	COG3344	reverse transcriptase
HYG84_11295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_11300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYG84_11310	COG1592	Rubrerythrin
HYG84_11315	COG2081	HI0933 family
HYG84_11320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYG84_11330	COG1217	gtp-binding protein TYPA
HYG84_11340	COG1193	negative regulation of DNA recombination
HYG84_11345	COG1683	Conserved Protein
HYG84_11350	COG0018	arginyl-trna synthetase
HYG84_11370	COG1032	radical SAM domain protein
HYG84_11385	COG0280	phosphate acetyltransferase
HYG84_11530	COG1361	Conserved repeat domain
HYG84_11530	COG3266	domain, Protein
HYG84_11530	COG2911	Protein conserved in bacteria
HYG84_11535	COG0210	DNA helicase
HYG84_11550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYG84_11560	COG1104	cysteine desulfurase activity
HYG84_11565	COG0301	tRNA thio-modification
HYG84_11575	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYG84_11580	COG1950	PFAM Membrane protein of
HYG84_11590	COG0519	Catalyzes the synthesis of GMP from XMP
HYG84_11600	COG2172	sigma factor antagonist activity
HYG84_11605	COG1191	sigma factor activity
HYG84_11630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_11655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYG84_11670	COG1739	Uncharacterized protein family UPF0029
HYG84_11690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG84_11695	COG0217	transcriptional regulatory protein
HYG84_11705	COG2153	protein acetylation
HYG84_11725	COG0217	transcriptional regulatory protein
HYG84_11730	COG0791	NLP P60 protein
HYG84_11730	COG1388	LysM domain
HYG84_11730	COG3103	Sh3 type 3 domain protein
HYG84_11735	COG0741	lytic transglycosylase activity
HYG84_11745	COG4656	Part of a membrane complex involved in electron transport
HYG84_11750	COG4658	electron transport chain
HYG84_11755	COG4659	FMN binding
HYG84_11760	COG4660	Part of a membrane complex involved in electron transport
HYG84_11765	COG4657	Part of a membrane complex involved in electron transport
HYG84_11770	COG1245	4Fe-4S binding domain
HYG84_11770	COG2878	Part of a membrane complex involved in electron transport
HYG84_11785	COG0424	maF-like protein
HYG84_11790	COG2003	Belongs to the UPF0758 family
HYG84_11795	COG1077	Cell shape determining protein MreB Mrl
HYG84_11810	COG0768	penicillin binding
HYG84_11815	COG0850	regulation of cytokinetic process
HYG84_11820	COG2894	cell division
HYG84_11825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HYG84_11850	COG1530	ribonuclease E activity
HYG84_11855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYG84_11870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYG84_11880	COG1534	Rna-binding protein
HYG84_11890	COG1713	HD superfamily hydrolase involved in NAD metabolism
HYG84_11895	COG1316	TRANSCRIPTIONal
HYG84_11900	COG0530	calcium, potassium:sodium antiporter activity
HYG84_11905	COG0799	negative regulation of ribosome biogenesis
HYG84_11915	COG0251	oxidation-reduction process
HYG84_11920	COG1760	l-serine dehydratase
HYG84_11925	COG1760	l-serine dehydratase
HYG84_11930	COG1686	Belongs to the peptidase S11 family
HYG84_11935	COG1596	polysaccharide export
HYG84_11935	COG1555	photosystem II stabilization
HYG84_11945	COG1115	amino acid carrier protein
HYG84_11950	COG1921	L-seryl-tRNASec selenium transferase activity
HYG84_11960	COG0745	RESPONSE REGULATOR receiver
HYG84_11965	COG5002	protein histidine kinase activity
HYG84_11975	COG1187	pseudouridine synthase activity
HYG84_11980	COG1268	BioY protein
HYG84_12005	COG2155	Conserved Protein
HYG84_12015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYG84_12020	COG0632	four-way junction helicase activity
HYG84_12025	COG2255	four-way junction helicase activity
HYG84_12030	COG2385	sporulation resulting in formation of a cellular spore
HYG84_12030	COG2247	cell wall binding repeat
HYG84_12045	COG1862	Preprotein translocase
HYG84_12060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_12070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG84_12075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYG84_12080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG84_12080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG84_12085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYG84_12090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYG84_12095	COG1490	D-aminoacyl-tRNA deacylase activity
HYG84_12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG84_12105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG84_12110	COG0124	histidyl-tRNA synthetase
HYG84_12130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYG84_12155	COG0653	protein targeting
HYG84_12185	COG1362	aminopeptidase activity
HYG84_12240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYG84_12245	COG3804	dihydrodipicolinate reductase
HYG84_12255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYG84_12265	COG5012	cobalamin binding
HYG84_12275	COG3457	Alanine racemase
HYG84_12300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYG84_12335	COG0010	Belongs to the arginase family
HYG84_12365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYG84_12390	COG3682	Transcriptional regulator
HYG84_12405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYG84_12425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYG84_12430	COG0798	PFAM Bile acid sodium symporter
HYG84_12440	COG0326	Molecular chaperone. Has ATPase activity
HYG84_12460	COG2340	Cysteine-rich secretory protein family
HYG84_12480	COG1959	2 iron, 2 sulfur cluster binding
HYG84_12505	COG0628	permease
HYG84_12510	COG0740	serine-type endopeptidase activity
HYG84_12515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYG84_12520	COG4472	Bacterial protein of unknown function (DUF965)
HYG84_12530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_12535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYG84_12540	COG3906	Belongs to the UPF0473 family
HYG84_12545	COG0735	belongs to the Fur family
HYG84_12550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYG84_12565	COG4122	O-methyltransferase activity
HYG84_12570	COG0826	peptidase U32
HYG84_12575	COG0572	uridine kinase
HYG84_12580	COG0768	penicillin binding
HYG84_12620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYG84_12625	COG0746	molybdenum cofactor guanylyltransferase activity
HYG84_12650	COG0243	molybdopterin cofactor binding
HYG84_12655	COG0437	4 iron, 4 sulfur cluster binding
HYG84_12665	COG0488	(ABC) transporter
HYG84_12765	COG1361	Conserved repeat domain
HYG84_12765	COG2911	Protein conserved in bacteria
HYG84_12765	COG3266	domain, Protein
HYG84_12775	COG3344	reverse transcriptase
HYG84_12845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYG84_12850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYG84_12855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG84_12865	COG1459	type II secretion system
HYG84_12890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYG84_12915	COG1361	Conserved repeat domain
HYG84_12920	COG4970	Tfp pilus assembly protein FimT
HYG84_12945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYG84_12950	COG0006	proline dipeptidase activity
HYG84_12955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYG84_12965	COG3854	ATPases associated with a variety of cellular activities
HYG84_13005	COG1302	Protein conserved in bacteria
HYG84_13010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG84_13015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYG84_13020	COG1570	exodeoxyribonuclease VII activity
HYG84_13025	COG1722	exodeoxyribonuclease VII activity
HYG84_13030	COG0142	geranyltranstransferase activity
HYG84_13035	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYG84_13045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYG84_13050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYG84_13055	COG1438	arginine binding
HYG84_13060	COG0497	DNA recombination
HYG84_13065	COG0750	zinc metalloprotease
HYG84_13075	COG2207	Transcriptional regulator
HYG84_13075	COG1917	Cupin 2, conserved barrel domain protein
HYG84_13080	COG0582	viral genome integration into host DNA
HYG84_13085	COG2137	regulation of response to DNA damage stimulus
HYG84_13100	COG0463	Glycosyl transferase, family 2
HYG84_13125	COG4974	Belongs to the 'phage' integrase family
HYG84_13130	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HYG84_13140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYG84_13150	COG1686	Belongs to the peptidase S11 family
HYG84_13155	COG1994	Peptidase M50
HYG84_13160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYG84_13165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYG84_13170	COG0010	Belongs to the arginase family
HYG84_13175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYG84_13180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYG84_13195	COG3874	Sporulation protein YtfJ
HYG84_13205	COG1686	Belongs to the peptidase S11 family
HYG84_13215	COG0445	tRNA wobble uridine modification
HYG84_13220	COG1187	pseudouridine synthase activity
HYG84_13230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYG84_13235	COG5016	pyruvate
HYG84_13235	COG0511	ligase activity, forming carbon-carbon bonds
HYG84_13245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYG84_13255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYG84_13255	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYG84_13260	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYG84_13275	COG0406	alpha-ribazole phosphatase activity
HYG84_13280	COG2081	HI0933 family
HYG84_13295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYG84_13300	COG0204	Acyl-transferase
HYG84_13305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYG84_13315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYG84_13325	COG1363	Peptidase, m42
HYG84_13335	COG0789	Transcriptional regulator
HYG84_13340	COG0436	Aminotransferase
HYG84_13350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG84_13355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG84_13360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYG84_13365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYG84_13370	COG1923	regulation of RNA biosynthetic process
HYG84_13375	COG0464	growth
HYG84_13380	COG1160	GTP binding
HYG84_13395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYG84_13400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYG84_13405	COG4974	Belongs to the 'phage' integrase family
HYG84_13420	COG3858	chitin binding
HYG84_13425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYG84_13440	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG84_13450	COG0693	protein deglycase activity
HYG84_13475	COG0613	PHP domain protein
HYG84_13480	COG2359	stage V sporulation protein S
HYG84_13485	COG1418	mRNA catabolic process
HYG84_13495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYG84_13500	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HYG84_13505	COG1674	ftsk spoiiie
HYG84_13510	COG0740	serine-type endopeptidase activity
HYG84_13520	COG0612	Peptidase, M16
HYG84_13525	COG0726	polysaccharide deacetylase
HYG84_13530	COG1185	polyribonucleotide nucleotidyltransferase activity
HYG84_13535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYG84_13540	COG0196	riboflavin kinase activity
HYG84_13545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYG84_13550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYG84_13555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYG84_13560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYG84_13570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYG84_13575	COG0195	Participates in both transcription termination and antitermination
HYG84_13580	COG0779	Required for maturation of 30S ribosomal subunits
HYG84_13590	COG0463	Glycosyl transferase, family 2
HYG84_13595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYG84_13600	COG0750	zinc metalloprotease
HYG84_13605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYG84_13610	COG0575	Belongs to the CDS family
HYG84_13625	COG0233	cytoplasmic translational termination
HYG84_13630	COG0528	UMP kinase activity
HYG84_13635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG84_13640	COG0052	Belongs to the universal ribosomal protein uS2 family
HYG84_13655	COG1191	sigma factor activity
HYG84_13660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYG84_13665	COG1776	CheC inhibitor of MCP methylation
HYG84_13670	COG0835	chemotaxis
HYG84_13675	COG2198	Histidine kinase
HYG84_13675	COG0643	Histidine kinase
HYG84_13680	COG2201	protein-glutamate methylesterase activity
HYG84_13695	COG1419	protein localization to endoplasmic reticulum
HYG84_13700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG84_13705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYG84_13710	COG1684	flagellar biosynthetic protein fliR
HYG84_13715	COG1987	bacterial-type flagellum assembly
HYG84_13720	COG1338	Plays a role in the flagellum-specific transport system
HYG84_13730	COG2201	protein-glutamate methylesterase activity
HYG84_13735	COG1776	CheC inhibitor of MCP methylation
HYG84_13735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_13740	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_13750	COG1360	Flagellar Motor Protein
HYG84_13775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYG84_13795	COG1157	protein secretion by the type III secretion system
HYG84_13805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYG84_13815	COG1677	Flagellar hook-basal body complex protein FliE
HYG84_13825	COG1815	bacterial-type flagellum-dependent cell motility
HYG84_13835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG84_13840	COG0758	DNA mediated transformation
HYG84_13850	COG0792	nuclease activity
HYG84_13855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYG84_13865	COG0335	large ribosomal subunit rRNA binding
HYG84_13870	COG0336	Belongs to the RNA methyltransferase TrmD family
HYG84_13875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYG84_13880	COG1837	Belongs to the UPF0109 family
HYG84_13885	COG0228	four-way junction DNA binding
HYG84_13890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYG84_13900	COG0552	protein localization to endoplasmic reticulum
HYG84_13905	COG1196	nuclear chromosome segregation
HYG84_13915	COG0571	ribonuclease III activity
HYG84_13920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYG84_13925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYG84_13930	COG1028	Short-chain dehydrogenase reductase Sdr
HYG84_13935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYG84_13945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_13950	COG0416	fatty acid biosynthetic process
HYG84_13960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYG84_13965	COG1399	metal-binding, possibly nucleic acid-binding protein
HYG84_13970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYG84_13975	COG1323	Belongs to the UPF0348 family
HYG84_13980	COG3314	Sporulation integral membrane protein YlbJ
HYG84_13990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYG84_13995	COG0742	ribosomal rna small subunit methyltransferase
HYG84_14000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYG84_14005	COG1461	Dihydroxyacetone kinase
HYG84_14010	COG1302	Protein conserved in bacteria
HYG84_14015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYG84_14030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYG84_14035	COG1162	GTPase activity
HYG84_14040	COG0515	serine threonine protein kinase
HYG84_14040	COG2815	serine threonine protein kinase
HYG84_14045	COG0631	protein serine/threonine phosphatase activity
HYG84_14050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYG84_14055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYG84_14055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYG84_14060	COG2738	Putative neutral zinc metallopeptidase
HYG84_14070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYG84_14075	COG0242	peptide deformylase activity
HYG84_14080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYG84_14085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYG84_14090	COG1758	RNA polymerase activity
HYG84_14095	COG0194	GDP metabolic process
HYG84_14100	COG2052	Domain of unknown function (DUF370)
HYG84_14105	COG1561	YicC-like family, N-terminal region
HYG84_14110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYG84_14125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYG84_14130	COG0564	pseudouridine synthase activity
HYG84_14135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYG84_14140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYG84_14150	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYG84_14155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYG84_14160	COG3599	regulation of cell shape
HYG84_14165	COG2302	S4 RNA-binding domain
HYG84_14175	COG1799	cell septum assembly
HYG84_14180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYG84_14195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYG84_14215	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HYG84_14220	COG0583	DNA-binding transcription factor activity
HYG84_14260	COG4974	Belongs to the 'phage' integrase family
HYG84_14270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYG84_14275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYG84_14280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYG84_14285	COG1160	GTP binding
HYG84_14325	COG5002	protein histidine kinase activity
HYG84_14330	COG0745	RESPONSE REGULATOR receiver
HYG84_14335	COG1496	oxidoreductase activity
HYG84_14340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYG84_14345	COG1873	PFAM PRC-barrel domain
HYG84_14350	COG1191	sigma factor activity
HYG84_14355	COG1191	sigma factor activity
HYG84_14365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYG84_14370	COG3856	small basic protein
HYG84_14385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYG84_14390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYG84_14395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYG84_14400	COG0772	Belongs to the SEDS family
HYG84_14405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYG84_14410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYG84_14415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYG84_14420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYG84_14425	COG0768	penicillin binding
HYG84_14435	COG0275	rRNA processing
HYG84_14440	COG2001	Belongs to the MraZ family
HYG84_14450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYG84_14455	COG0612	Peptidase, M16
HYG84_14460	COG0612	Peptidase, M16
HYG84_14475	COG0012	GTP binding
HYG84_14480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYG84_14495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYG84_14500	COG4869	propanediol catabolic process
HYG84_14505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYG84_14510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYG84_14515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYG84_14535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYG84_14540	COG2096	Adenosyltransferase
HYG84_14545	COG4608	Belongs to the ABC transporter superfamily
HYG84_14550	COG0444	Belongs to the ABC transporter superfamily
HYG84_14555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_14560	COG0601	transmembrane transport
HYG84_14565	COG0747	negative chemotaxis
HYG84_14570	COG4608	Belongs to the ABC transporter superfamily
HYG84_14575	COG0444	Belongs to the ABC transporter superfamily
HYG84_14580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_14585	COG0601	transmembrane transport
HYG84_14590	COG0747	negative chemotaxis
HYG84_14595	COG2030	dehydratase
HYG84_14605	COG4608	Belongs to the ABC transporter superfamily
HYG84_14610	COG0444	Belongs to the ABC transporter superfamily
HYG84_14615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYG84_14620	COG0601	transmembrane transport
HYG84_14650	COG3275	phosphorelay sensor kinase activity
HYG84_14660	COG1966	Carbon starvation protein
HYG84_14670	COG1695	Transcriptional regulator
HYG84_14685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYG84_14705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYG84_14710	COG2384	SAM-dependent methyltransferase
HYG84_14720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_14725	COG0358	DNA primase activity
HYG84_14730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG84_14745	COG1695	Transcriptional regulator
HYG84_14755	COG0251	oxidation-reduction process
HYG84_14765	COG0251	oxidation-reduction process
HYG84_14775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYG84_14795	COG1307	EDD domain protein, DegV family
HYG84_14830	COG1396	sequence-specific DNA binding
HYG84_14835	COG0431	NADPH-dependent FMN reductase
HYG84_14835	COG1053	succinate dehydrogenase
HYG84_14835	COG3976	FMN-binding domain protein
HYG84_14855	COG5002	protein histidine kinase activity
HYG84_14885	COG0574	Belongs to the PEP-utilizing enzyme family
HYG84_14885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYG84_14890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HYG84_14895	COG0517	IMP dehydrogenase activity
HYG84_14900	COG0423	glycine-tRNA ligase activity
HYG84_14905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYG84_14910	COG1381	Involved in DNA repair and RecF pathway recombination
HYG84_14920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYG84_14925	COG0295	cytidine deaminase activity
HYG84_14930	COG1470	cell adhesion involved in biofilm formation
HYG84_14940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYG84_14945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYG84_14950	COG1480	7TM receptor with intracellular HD hydrolase
HYG84_14955	COG1702	phosphate starvation-inducible protein PhoH
HYG84_14990	COG4864	UPF0365 protein
HYG84_14995	COG1030	water channel activity
HYG84_15005	COG1610	YqeY-like protein
HYG84_15010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYG84_15015	COG0537	adenosine 5'-monophosphoramidase activity
HYG84_15020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYG84_15030	COG1674	ftsk spoiiie
HYG84_15230	COG0175	sulfate reduction
HYG84_15315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYG84_15320	COG2264	protein methyltransferase activity
HYG84_15325	COG0484	heat shock protein binding
HYG84_15330	COG0443	Heat shock 70 kDa protein
HYG84_15335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYG84_15340	COG1420	regulation of RNA biosynthetic process
HYG84_15345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYG84_15350	COG0481	GTPase activity
HYG84_15365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HYG84_15370	COG0268	Binds directly to 16S ribosomal RNA
HYG84_15380	COG0658	competence protein
HYG84_15380	COG2333	competence protein COMEC
HYG84_15400	COG0658	competence protein
HYG84_15400	COG2333	competence protein COMEC
HYG84_15425	COG0513	Belongs to the DEAD box helicase family
HYG84_15430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_15435	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_15445	COG0577	efflux transmembrane transporter activity
HYG84_15445	COG1136	(ABC) transporter
HYG84_15480	COG0237	dephospho-CoA kinase activity
HYG84_15485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_15485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_15495	COG1595	DNA-templated transcription, initiation
HYG84_15510	COG2357	RelA SpoT domain protein
HYG84_15525	COG0583	DNA-binding transcription factor activity
HYG84_15530	COG1307	EDD domain protein, DegV family
HYG84_15550	COG0835	chemotaxis
HYG84_15555	COG4224	UPF0291 protein
HYG84_15570	COG1228	amidohydrolase
HYG84_15575	COG2986	histidine ammonia-lyase
HYG84_15580	COG3706	GGDEF domain
HYG84_15585	COG1846	Transcriptional regulator
HYG84_15590	COG1597	lipid kinase activity
HYG84_15595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_15605	COG1132	(ABC) transporter
HYG84_15610	COG1132	(ABC) transporter
HYG84_15625	COG2199	diguanylate cyclase activity
HYG84_15630	COG2244	polysaccharide biosynthetic process
HYG84_15650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_15665	COG0534	Mate efflux family protein
HYG84_15670	COG0564	pseudouridine synthase activity
HYG84_15675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYG84_15685	COG3383	formate dehydrogenase (NAD+) activity
HYG84_15690	COG0437	4 iron, 4 sulfur cluster binding
HYG84_15710	COG1164	Oligoendopeptidase f
HYG84_15715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYG84_15720	COG1053	succinate dehydrogenase
HYG84_15740	COG4659	FMN binding
HYG84_15760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYG84_15765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYG84_15770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYG84_15790	COG2094	Belongs to the DNA glycosylase MPG family
HYG84_15810	COG0406	alpha-ribazole phosphatase activity
HYG84_15815	COG2824	Alkylphosphonate utilization operon protein PhnA
HYG84_15825	COG2333	competence protein COMEC
HYG84_15825	COG0658	competence protein
HYG84_15830	COG0840	transmembrane signaling receptor activity
HYG84_15835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_15865	COG1285	pathogenesis
HYG84_15890	COG0647	UMP catabolic process
HYG84_15895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYG84_15905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HYG84_15955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYG84_16075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYG84_16140	COG0629	single-stranded DNA binding
HYG84_16145	COG1484	DNA-dependent DNA replication
HYG84_16175	COG1396	sequence-specific DNA binding
HYG84_16185	COG0582	viral genome integration into host DNA
HYG84_16195	COG2268	Band 7 protein
HYG84_16210	COG1983	PspC domain protein
HYG84_16220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYG84_16225	COG3314	Sporulation integral membrane protein YlbJ
HYG84_16230	COG0037	tRNA processing
HYG84_16235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYG84_16245	COG1846	Transcriptional regulator
HYG84_16270	COG0583	DNA-binding transcription factor activity
HYG84_16275	COG2391	methyltransferase activity
HYG84_16285	COG2391	methyltransferase activity
HYG84_16290	COG0450	alkyl hydroperoxide reductase
HYG84_16295	COG3973	AAA domain
HYG84_16305	COG0583	DNA-binding transcription factor activity
HYG84_16310	COG0514	ATP-dependent DNA helicase (RecQ)
HYG84_16320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYG84_16325	COG0581	inorganic phosphate transmembrane transporter activity
HYG84_16330	COG0573	inorganic phosphate transmembrane transporter activity
HYG84_16340	COG0733	neurotransmitter:sodium symporter activity
HYG84_16380	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYG84_16390	COG1120	ATPase activity
HYG84_16395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_16400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG84_16405	COG2205	protein histidine kinase activity
HYG84_16420	COG0745	RESPONSE REGULATOR receiver
HYG84_16435	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYG84_16440	COG2205	protein histidine kinase activity
HYG84_16445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_16445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_16450	COG2362	D-Aminopeptidase
HYG84_16455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYG84_16465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYG84_16470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYG84_16480	COG0500	methyltransferase
HYG84_16500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYG84_16510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYG84_16545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYG84_16570	COG0076	glutamate decarboxylase activity
HYG84_16575	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HYG84_16580	COG3973	AAA domain
HYG84_16590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYG84_16595	COG0557	exoribonuclease II activity
HYG84_16610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYG84_16615	COG0148	phosphopyruvate hydratase activity
HYG84_16625	COG0149	triose-phosphate isomerase activity
HYG84_16630	COG0126	phosphoglycerate kinase activity
HYG84_16645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYG84_16650	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYG84_16655	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYG84_16660	COG3845	ABC transporter
HYG84_16665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYG84_16670	COG1328	CTP reductase activity
HYG84_16675	COG1744	ABC transporter substrate-binding protein PnrA-like
HYG84_16705	COG3118	belongs to the thioredoxin family
HYG84_16720	COG1307	EDD domain protein, DegV family
HYG84_16725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYG84_16730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYG84_16750	COG0488	(ABC) transporter
HYG84_16765	COG1012	belongs to the aldehyde dehydrogenase family
HYG84_16775	COG0646	methionine synthase
HYG84_16775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYG84_16780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYG84_16800	COG0583	DNA-binding transcription factor activity
HYG84_16810	COG1971	Probably functions as a manganese efflux pump
HYG84_16815	COG1116	anion transmembrane transporter activity
HYG84_16855	COG0737	Belongs to the 5'-nucleotidase family
HYG84_16860	COG0561	phosphatase activity
HYG84_16865	COG0735	belongs to the Fur family
HYG84_16870	COG1120	ATPase activity
HYG84_16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYG84_16880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYG84_16890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYG84_16900	COG2720	vancomycin resistance protein
HYG84_16920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYG84_16925	COG0156	8-amino-7-oxononanoate synthase activity
HYG84_16930	COG1067	ATP-dependent peptidase activity
HYG84_16940	COG0681	Belongs to the peptidase S26 family
HYG84_16965	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYG84_17005	COG3299	homolog of phage Mu protein gp47
HYG84_17020	COG4193	domain, Protein
HYG84_17110	COG3728	DNA packaging
HYG84_17110	COG5484	DNA packaging
HYG84_17130	COG0443	Heat shock 70 kDa protein
HYG84_17160	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HYG84_17260	COG3645	SOS response
HYG84_17260	COG3646	Phage regulatory protein
HYG84_17285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYG84_17305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYG84_17325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYG84_17330	COG0482	sulfurtransferase activity
HYG84_17350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_17355	COG3279	Response regulator of the LytR AlgR family
HYG84_17360	COG3275	phosphorelay sensor kinase activity
HYG84_17400	COG4175	Glycine betaine
HYG84_17400	COG0517	IMP dehydrogenase activity
HYG84_17405	COG1510	regulation of RNA biosynthetic process
HYG84_17425	COG0028	Belongs to the TPP enzyme family
HYG84_17435	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HYG84_17445	COG1136	(ABC) transporter
HYG84_17450	COG3850	Histidine kinase
HYG84_17450	COG5002	protein histidine kinase activity
HYG84_17465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYG84_17465	COG3608	succinylglutamate desuccinylase aspartoacylase
HYG84_17470	COG0840	transmembrane signaling receptor activity
HYG84_17475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYG84_17485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYG84_17490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HYG84_17495	COG1304	FMN binding
HYG84_17500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYG84_17525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYG84_17770	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HYG84_17820	COG0563	adenylate kinase activity
HYG84_18045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYG84_18110	COG0653	protein targeting
HYG84_18120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYG84_18155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYG84_18265	COG4974	Belongs to the 'phage' integrase family
HYG84_18270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYG84_18280	COG2165	general secretion pathway protein
HYG84_18335	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYG84_18350	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYG84_18375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYG84_18375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYG84_18395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYG84_18470	COG0557	exoribonuclease II activity
HYG84_18475	COG0840	transmembrane signaling receptor activity
HYG84_18640	COG0358	DNA primase activity
HYG84_18670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYG84_18690	COG0494	nUDIX hydrolase
HYG84_18715	COG0210	DNA helicase
HYG84_18805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYG84_18825	COG1358	cellular component organization or biogenesis
HYG84_18850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYG84_18870	COG0681	Belongs to the peptidase S26 family
HYG84_18910	COG2165	general secretion pathway protein
HYG84_18915	COG2133	pyrroloquinoline quinone binding
HYG84_18915	COG5183	chlorophyll binding
HYG84_18995	COG3266	domain, Protein
HYG84_18995	COG2911	Protein conserved in bacteria
HYG84_18995	COG1361	Conserved repeat domain
HYG84_19095	COG0551	DNA topoisomerase type I activity
HYG84_19095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYG84_19200	COG0629	single-stranded DNA binding
HYG84_19250	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYG84_19260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYG84_19410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYG84_19415	COG0187	DNA topoisomerase II activity
HYG84_19425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYG84_19460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_19465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYG84_19500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYG84_19540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYG84_19590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_19590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYG84_19625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYG84_19650	COG3773	Cell wall hydrolase
HYG84_19665	COG2165	general secretion pathway protein
HYG84_19685	COG1459	type II secretion system
HYG84_19690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYG84_19770	COG2165	general secretion pathway protein
HYG84_19795	COG0330	HflC and HflK could
HYG84_19800	COG0330	HflC and HflK could
HYG84_19805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYG84_19870	COG4474	Belongs to the UPF0398 family
HYG84_19930	COG0793	Belongs to the peptidase S41A family
HYG84_19930	COG3409	Peptidoglycan-binding domain 1 protein
HYG84_19990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYG84_20010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_20010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYG84_20095	COG2176	DNA-directed DNA polymerase activity