locus-tag	class	description
KWG62_00010	COG1904	glucuronate isomerase
KWG62_00025	COG0800	Aldolase
KWG62_00030	COG0246	Mannitol dehydrogenase
KWG62_00035	COG1312	Catalyzes the dehydration of D-mannonate
KWG62_00045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KWG62_00075	COG2176	DNA-directed DNA polymerase activity
KWG62_00090	COG0493	'glutamate synthase
KWG62_00095	COG0067	glutamate synthase
KWG62_00095	COG0069	glutamate synthase activity
KWG62_00095	COG0070	glutamate synthase
KWG62_00100	COG0367	asparagine synthase
KWG62_00140	COG2197	response regulator
KWG62_00160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG62_00190	COG0174	glutamine synthetase
KWG62_00200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG62_00220	COG0504	CTP synthase activity
KWG62_00250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWG62_00260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KWG62_00265	COG1160	GTP binding
KWG62_00270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KWG62_00275	COG0776	regulation of translation
KWG62_00280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KWG62_00290	COG1126	abc transporter atp-binding protein
KWG62_00295	COG0765	amino acid transport
KWG62_00335	COG1358	cellular component organization or biogenesis
KWG62_00400	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_00405	COG0446	pyridine nucleotide-disulphide oxidoreductase
KWG62_00415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG62_00445	COG0561	phosphatase activity
KWG62_00465	COG0577	efflux transmembrane transporter activity
KWG62_00465	COG1136	(ABC) transporter
KWG62_00480	COG0668	transmembrane transport
KWG62_00525	COG2188	Transcriptional regulator
KWG62_00555	COG3328	transposase activity
KWG62_00630	COG0500	methyltransferase
KWG62_00640	COG0497	DNA recombination
KWG62_00650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KWG62_00660	COG1722	exodeoxyribonuclease VII activity
KWG62_00665	COG1570	exodeoxyribonuclease VII activity
KWG62_00670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG62_00680	COG0196	riboflavin kinase activity
KWG62_00690	COG0037	tRNA processing
KWG62_00700	COG1393	Belongs to the ArsC family
KWG62_00710	COG2078	PFAM AMMECR1 domain protein
KWG62_00710	COG3885	ferrous iron binding
KWG62_00715	COG1702	phosphate starvation-inducible protein PhoH
KWG62_00720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KWG62_00725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KWG62_00730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_00740	COG1187	pseudouridine synthase activity
KWG62_00745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KWG62_00770	COG0494	nUDIX hydrolase
KWG62_00785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KWG62_00835	COG1024	Enoyl-CoA hydratase
KWG62_00840	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWG62_00850	COG2086	electron transfer activity
KWG62_00855	COG1960	acyl-CoA dehydrogenase activity
KWG62_00860	COG0183	Belongs to the thiolase family
KWG62_00905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KWG62_00915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KWG62_00920	COG0195	Participates in both transcription termination and antitermination
KWG62_00925	COG0779	Required for maturation of 30S ribosomal subunits
KWG62_00930	COG0194	GDP metabolic process
KWG62_00965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KWG62_00970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KWG62_00975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KWG62_00980	COG1609	Transcriptional regulator
KWG62_00995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWG62_01005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWG62_01010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KWG62_01020	COG1185	polyribonucleotide nucleotidyltransferase activity
KWG62_01030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KWG62_01035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KWG62_01040	COG0481	GTPase activity
KWG62_01045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWG62_01050	COG0268	Binds directly to 16S ribosomal RNA
KWG62_01085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KWG62_01090	COG3906	Belongs to the UPF0473 family
KWG62_01095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KWG62_01100	COG4472	Bacterial protein of unknown function (DUF965)
KWG62_01105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KWG62_01110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWG62_01115	COG0482	sulfurtransferase activity
KWG62_01130	COG1648	precorrin-2 dehydrogenase activity
KWG62_01130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG62_01135	COG1648	precorrin-2 dehydrogenase activity
KWG62_01135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG62_01140	COG0494	nUDIX hydrolase
KWG62_01145	COG1120	ATPase activity
KWG62_01150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_01155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KWG62_01220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KWG62_01250	COG0516	GMP reductase activity
KWG62_01250	COG0517	IMP dehydrogenase activity
KWG62_01255	COG1523	belongs to the glycosyl hydrolase 13 family
KWG62_01260	COG0114	fumarate hydratase activity
KWG62_01265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWG62_01285	COG0655	NAD(P)H dehydrogenase (quinone) activity
KWG62_01290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KWG62_01295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KWG62_01340	COG3436	PFAM IS66 Orf2 family protein
KWG62_01380	COG2205	protein histidine kinase activity
KWG62_01400	COG0745	RESPONSE REGULATOR receiver
KWG62_01405	COG1283	sodium-dependent phosphate transmembrane transporter activity
KWG62_01420	COG3328	transposase activity
KWG62_01430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG62_01435	COG2239	Acts as a magnesium transporter
KWG62_01440	COG2239	Acts as a magnesium transporter
KWG62_01450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_01455	COG1132	(ABC) transporter
KWG62_01460	COG1132	(ABC) transporter
KWG62_01495	COG0124	histidyl-tRNA synthetase
KWG62_01500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KWG62_01510	COG0343	queuine tRNA-ribosyltransferase activity
KWG62_01520	COG0326	Molecular chaperone. Has ATPase activity
KWG62_01530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KWG62_01535	COG3328	transposase activity
KWG62_01585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KWG62_01590	COG0151	Belongs to the GarS family
KWG62_01600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KWG62_01610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KWG62_01615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KWG62_01620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KWG62_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KWG62_01640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KWG62_01650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KWG62_01655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KWG62_01670	COG0588	phosphoglycerate mutase activity
KWG62_01685	COG0205	6-phosphofructokinase activity
KWG62_01695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KWG62_01700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KWG62_01705	COG0561	phosphatase activity
KWG62_01720	COG1362	aminopeptidase activity
KWG62_01740	COG5002	protein histidine kinase activity
KWG62_01745	COG0745	RESPONSE REGULATOR receiver
KWG62_01755	COG0140	phosphoribosyl-ATP diphosphatase activity
KWG62_01770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KWG62_01775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KWG62_01785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWG62_01790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KWG62_01795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KWG62_01810	COG0561	phosphatase activity
KWG62_01840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG62_01845	COG0372	Belongs to the citrate synthase family
KWG62_01855	COG0778	Nitroreductase
KWG62_01875	COG0538	isocitrate dehydrogenase activity
KWG62_01895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWG62_01925	COG1393	Belongs to the ArsC family
KWG62_01965	COG1309	transcriptional regulator
KWG62_01975	COG1461	Dihydroxyacetone kinase
KWG62_01980	COG1302	Protein conserved in bacteria
KWG62_01990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG62_02005	COG0363	glucosamine-6-phosphate deaminase activity
KWG62_02020	COG3716	PTS system mannose fructose sorbose family IID component
KWG62_02025	COG3715	PTS system
KWG62_02030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_02095	COG0740	serine-type endopeptidase activity
KWG62_02110	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_02125	COG2222	sugar isomerase
KWG62_02145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWG62_02155	COG0281	malic enzyme
KWG62_02160	COG2195	Cleaves the N-terminal amino acid of tripeptides
KWG62_02325	COG0424	maF-like protein
KWG62_02345	COG0083	homoserine kinase activity
KWG62_02355	COG0460	homoserine dehydrogenase
KWG62_02360	COG0527	aspartate kinase activity
KWG62_02365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KWG62_02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWG62_02400	COG0646	methionine synthase
KWG62_02400	COG1410	methionine synthase
KWG62_02405	COG0646	methionine synthase
KWG62_02405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KWG62_02450	COG1278	Cold shock
KWG62_02465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KWG62_02470	COG0719	Fe-S assembly protein
KWG62_02480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KWG62_02485	COG0719	Fe-S assembly protein
KWG62_02490	COG0396	ATPase activity
KWG62_02495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWG62_02655	COG0740	serine-type endopeptidase activity
KWG62_02675	COG4626	Terminase
KWG62_02675	COG1802	Transcriptional regulator
KWG62_02740	COG1403	HNH endonuclease
KWG62_02955	COG0740	serine-type endopeptidase activity
KWG62_02975	COG4626	Terminase
KWG62_02975	COG1802	Transcriptional regulator
KWG62_03035	COG1403	HNH endonuclease
KWG62_03120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_03120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_03130	COG4716	Myosin-crossreactive antigen
KWG62_03255	COG0542	response to heat
KWG62_03280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KWG62_03290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_03295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG62_03295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KWG62_03315	COG2176	DNA-directed DNA polymerase activity
KWG62_03315	COG5002	protein histidine kinase activity
KWG62_03320	COG0739	heme binding
KWG62_03375	COG0454	-acetyltransferase
KWG62_03390	COG2827	Endonuclease containing a URI domain
KWG62_03400	COG2873	o-acetylhomoserine
KWG62_03405	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KWG62_03410	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_03415	COG0488	(ABC) transporter
KWG62_03460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWG62_03470	COG0017	Asparaginyl-tRNA synthetase
KWG62_03475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KWG62_03510	COG1481	regulation of sporulation
KWG62_03515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KWG62_03520	COG1660	Displays ATPase and GTPase activities
KWG62_03530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG62_03555	COG0789	Transcriptional regulator
KWG62_03555	COG4978	Transcriptional regulator
KWG62_03575	COG1126	abc transporter atp-binding protein
KWG62_03580	COG0765	amino acid transport
KWG62_03615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KWG62_03625	COG0210	DNA helicase
KWG62_03630	COG1597	lipid kinase activity
KWG62_03635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWG62_03640	COG1091	dTDP-4-dehydrorhamnose reductase activity
KWG62_03655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KWG62_03670	COG1215	transferase activity, transferring glycosyl groups
KWG62_03680	COG1316	TRANSCRIPTIONal
KWG62_03730	COG0426	domain, Protein
KWG62_03820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KWG62_03825	COG0009	L-threonylcarbamoyladenylate synthase
KWG62_03830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KWG62_03850	COG1696	Membrane protein involved in D-alanine export
KWG62_03900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KWG62_03930	COG2365	Tyrosine phosphatase family
KWG62_03960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_03975	COG0826	peptidase U32
KWG62_03995	COG1051	belongs to the nudix hydrolase family
KWG62_04005	COG1609	Transcriptional regulator
KWG62_04010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KWG62_04015	COG1621	beta-fructofuranosidase activity
KWG62_04020	COG2190	(PTS) system
KWG62_04020	COG1263	PTS System
KWG62_04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_04025	COG0252	asparaginase activity
KWG62_04060	COG3328	transposase activity
KWG62_04070	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_04090	COG1196	nuclear chromosome segregation
KWG62_04105	COG4211	Belongs to the binding-protein-dependent transport system permease family
KWG62_04140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KWG62_04155	COG0058	SHG alpha-glucan phosphorylase activity
KWG62_04175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KWG62_04175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWG62_04195	COG0514	ATP-dependent DNA helicase (RecQ)
KWG62_04200	COG2171	N-acyltransferase activity
KWG62_04205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KWG62_04210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWG62_04230	COG0561	phosphatase activity
KWG62_04250	COG3291	Pkd domain containing protein
KWG62_04250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG62_04280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG62_04280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_04280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG62_04285	COG1105	Belongs to the carbohydrate kinase PfkB family
KWG62_04290	COG1349	DNA-binding transcription factor activity
KWG62_04295	COG0698	ribose 5-phosphate isomerase
KWG62_04300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KWG62_04310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KWG62_04335	COG0613	PHP domain protein
KWG62_04365	COG3142	Participates in the control of copper homeostasis
KWG62_04430	COG1454	alcohol dehydrogenase
KWG62_04490	COG0653	protein targeting
KWG62_04500	COG0561	phosphatase activity
KWG62_04540	COG2357	RelA SpoT domain protein
KWG62_04545	COG1611	Belongs to the LOG family
KWG62_04555	COG0473	3-isopropylmalate dehydrogenase activity
KWG62_04565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG62_04570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KWG62_04575	COG1739	Uncharacterized protein family UPF0029
KWG62_04610	COG1620	l-lactate permease
KWG62_04615	COG2001	Belongs to the MraZ family
KWG62_04620	COG0275	rRNA processing
KWG62_04630	COG0768	penicillin binding
KWG62_04640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KWG62_04665	COG0742	ribosomal rna small subunit methyltransferase
KWG62_04675	COG2205	protein histidine kinase activity
KWG62_04680	COG0745	RESPONSE REGULATOR receiver
KWG62_04740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KWG62_04745	COG0789	Transcriptional regulator
KWG62_04810	COG0667	Aldo Keto reductase
KWG62_04835	COG4133	protoheme IX ABC transporter activity
KWG62_04840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KWG62_04845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWG62_04850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KWG62_04855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KWG62_04860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KWG62_04865	COG0165	Argininosuccinate lyase
KWG62_04870	COG0137	argininosuccinate synthase activity
KWG62_04915	COG1215	transferase activity, transferring glycosyl groups
KWG62_04920	COG0438	transferase activity, transferring glycosyl groups
KWG62_04935	COG1473	amidohydrolase
KWG62_04940	COG0019	diaminopimelate decarboxylase activity
KWG62_04945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KWG62_04960	COG2188	Transcriptional regulator
KWG62_05005	COG0515	serine threonine protein kinase
KWG62_05005	COG3266	domain, Protein
KWG62_05010	COG0515	serine threonine protein kinase
KWG62_05050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KWG62_05075	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KWG62_05225	COG3250	beta-galactosidase activity
KWG62_05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KWG62_05265	COG0581	inorganic phosphate transmembrane transporter activity
KWG62_05270	COG0573	inorganic phosphate transmembrane transporter activity
KWG62_05320	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KWG62_05410	COG1114	Component of the transport system for branched-chain amino acids
KWG62_05425	COG1695	Transcriptional regulator
KWG62_05440	COG3064	Membrane
KWG62_05440	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG62_05440	COG3583	domain protein
KWG62_05455	COG1131	(ABC) transporter
KWG62_05460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG62_05465	COG0656	L-ascorbic acid biosynthetic process
KWG62_05470	COG0583	DNA-binding transcription factor activity
KWG62_05495	COG1876	peptidase activity
KWG62_05525	COG0393	Putative heavy-metal-binding
KWG62_05535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KWG62_05540	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KWG62_05545	COG3842	ATPase activity
KWG62_05560	COG0058	SHG alpha-glucan phosphorylase activity
KWG62_05635	COG1876	peptidase activity
KWG62_05670	COG0842	Transport permease protein
KWG62_05670	COG1131	(ABC) transporter
KWG62_05670	COG1716	ATPase activity
KWG62_05675	COG1716	ATPase activity
KWG62_05740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KWG62_05745	COG1420	regulation of RNA biosynthetic process
KWG62_05750	COG1496	oxidoreductase activity
KWG62_05775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KWG62_05795	COG1640	4-alpha-glucanotransferase
KWG62_05810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KWG62_05820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWG62_05835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG62_05880	COG3711	transcriptional antiterminator
KWG62_05885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_05885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_05890	COG1105	Belongs to the carbohydrate kinase PfkB family
KWG62_05895	COG1063	alcohol dehydrogenase
KWG62_05965	COG0492	ferredoxin-NADP+ reductase activity
KWG62_05965	COG3118	belongs to the thioredoxin family
KWG62_05975	COG1012	belongs to the aldehyde dehydrogenase family
KWG62_05980	COG3118	belongs to the thioredoxin family
KWG62_05985	COG0628	permease
KWG62_05995	COG0741	lytic transglycosylase activity
KWG62_05995	COG0791	NLP P60 protein
KWG62_06005	COG1316	TRANSCRIPTIONal
KWG62_06015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KWG62_06060	COG1733	regulation of RNA biosynthetic process
KWG62_06080	COG0110	maltose O-acetyltransferase activity
KWG62_06095	COG0151	Belongs to the GarS family
KWG62_06100	COG0726	polysaccharide deacetylase
KWG62_06115	COG0492	ferredoxin-NADP+ reductase activity
KWG62_06125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KWG62_06135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KWG62_06140	COG1774	PSP1 C-terminal conserved region
KWG62_06150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KWG62_06165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KWG62_06180	COG1253	flavin adenine dinucleotide binding
KWG62_06185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KWG62_06190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KWG62_06195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWG62_06200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWG62_06205	COG0772	Belongs to the SEDS family
KWG62_06230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KWG62_06235	COG0590	tRNA wobble adenosine to inosine editing
KWG62_06250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KWG62_06260	COG1595	DNA-templated transcription, initiation
KWG62_06280	COG2501	S4 domain
KWG62_06290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KWG62_06295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KWG62_06305	COG0706	membrane insertase activity
KWG62_06310	COG1847	R3H domain protein
KWG62_06315	COG0193	aminoacyl-tRNA hydrolase activity
KWG62_06320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KWG62_06325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KWG62_06330	COG1078	dGTPase activity
KWG62_06340	COG0018	arginyl-trna synthetase
KWG62_06345	COG3343	RNA polymerase activity
KWG62_06365	COG0357	Ribosomal RNA small subunit methyltransferase G
KWG62_06370	COG1192	Involved in chromosome partitioning
KWG62_06375	COG1475	DNA binding
KWG62_06390	COG0562	UDP-galactopyranose mutase
KWG62_06400	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KWG62_06415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KWG62_06425	COG0084	hydrolase, TatD family'
KWG62_06435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KWG62_06440	COG2890	protein-(glutamine-N5) methyltransferase activity
KWG62_06445	COG0024	Methionine aminopeptidase
KWG62_06505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KWG62_06515	COG0463	Glycosyl transferase, family 2
KWG62_06520	COG1215	transferase activity, transferring glycosyl groups
KWG62_06565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KWG62_06585	COG0561	phosphatase activity
KWG62_06615	COG2813	Specifically methylates the guanine in position
KWG62_06625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWG62_06635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG62_06640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KWG62_06660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KWG62_06670	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KWG62_06675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_06685	COG1074	ATP-dependent DNA helicase activity
KWG62_06690	COG2252	PERMEase
KWG62_06705	COG1696	Membrane protein involved in D-alanine export
KWG62_06765	COG3842	ATPase activity
KWG62_06770	COG1176	ABC-type spermidine putrescine transport system, permease component I
KWG62_06775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KWG62_06810	COG0602	queuosine metabolic process
KWG62_06825	COG3250	beta-galactosidase activity
KWG62_06840	COG1979	alcohol dehydrogenase
KWG62_06865	COG2244	polysaccharide biosynthetic process
KWG62_06900	COG0438	transferase activity, transferring glycosyl groups
KWG62_06910	COG0438	transferase activity, transferring glycosyl groups
KWG62_06915	COG3481	metal-dependent phosphohydrolase, HD sub domain
KWG62_06920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_06950	COG3769	mannosylglycerate metabolic process
KWG62_06965	COG0583	DNA-binding transcription factor activity
KWG62_07040	COG1476	TRANSCRIPTIONal
KWG62_07050	COG0312	modulator of DNA gyrase
KWG62_07110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KWG62_07115	COG0505	Belongs to the CarA family
KWG62_07120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KWG62_07125	COG0543	2 iron, 2 sulfur cluster binding
KWG62_07130	COG0167	dihydroorotate dehydrogenase activity
KWG62_07165	COG3250	beta-galactosidase activity
KWG62_07205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KWG62_07215	COG0747	negative chemotaxis
KWG62_07225	COG0601	transmembrane transport
KWG62_07235	COG0444	Belongs to the ABC transporter superfamily
KWG62_07240	COG4608	Belongs to the ABC transporter superfamily
KWG62_07255	COG0456	acetyltransferase
KWG62_07295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KWG62_07300	COG0802	atpase or kinase
KWG62_07305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KWG62_07310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KWG62_07310	COG0456	acetyltransferase
KWG62_07320	COG0519	Catalyzes the synthesis of GMP from XMP
KWG62_07320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KWG62_07325	COG3250	beta-galactosidase activity
KWG62_07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_07345	COG1120	ATPase activity
KWG62_07360	COG1136	(ABC) transporter
KWG62_07365	COG2205	protein histidine kinase activity
KWG62_07380	COG1472	Belongs to the glycosyl hydrolase 3 family
KWG62_07385	COG0436	Aminotransferase
KWG62_07445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG62_07500	COG2738	Putative neutral zinc metallopeptidase
KWG62_07520	COG1328	CTP reductase activity
KWG62_07525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KWG62_07530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KWG62_07545	COG2233	PERMEase
KWG62_07560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG62_07570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KWG62_07575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG62_07580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG62_07595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KWG62_07600	COG0537	adenosine 5'-monophosphoramidase activity
KWG62_07605	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWG62_07610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KWG62_07620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KWG62_07630	COG1160	GTP binding
KWG62_07640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KWG62_07645	COG0799	negative regulation of ribosome biogenesis
KWG62_07650	COG2226	methyltransferase
KWG62_07655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KWG62_07675	COG0433	COG0433 Predicted ATPase
KWG62_07690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KWG62_07710	COG3764	Sortase (surface protein transpeptidase)
KWG62_07735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KWG62_07740	COG1929	Belongs to the glycerate kinase type-1 family
KWG62_07755	COG1592	Rubrerythrin
KWG62_07770	COG0420	3'-5' exonuclease activity
KWG62_07775	COG0419	ATPase involved in DNA repair
KWG62_07810	COG3328	transposase activity
KWG62_07820	COG0598	Magnesium transport protein CorA
KWG62_07825	COG0793	Belongs to the peptidase S41A family
KWG62_07825	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_07835	COG0285	dihydrofolate synthase activity
KWG62_07840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KWG62_07845	COG0556	nucleotide-excision repair
KWG62_07850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KWG62_07870	COG0280	phosphate acetyltransferase
KWG62_07885	COG3830	Belongs to the UPF0237 family
KWG62_07890	COG2848	UPF0210 protein
KWG62_07900	COG0765	amino acid transport
KWG62_07905	COG1126	abc transporter atp-binding protein
KWG62_07940	COG1857	crispr-associated protein
KWG62_07955	COG1518	maintenance of DNA repeat elements
KWG62_07960	COG2176	DNA-directed DNA polymerase activity
KWG62_07990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KWG62_07995	COG0081	regulation of translation
KWG62_08000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KWG62_08030	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KWG62_08035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KWG62_08045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG62_08050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWG62_08055	COG0531	amino acid
KWG62_08060	COG1362	aminopeptidase activity
KWG62_08075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KWG62_08085	COG0089	rRNA binding
KWG62_08090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KWG62_08105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KWG62_08115	COG0255	Belongs to the universal ribosomal protein uL29 family
KWG62_08120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KWG62_08125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KWG62_08135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KWG62_08140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KWG62_08145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KWG62_08150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KWG62_08155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KWG62_08160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KWG62_08165	COG0200	Binds to the 23S rRNA
KWG62_08175	COG0563	adenylate kinase activity
KWG62_08180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KWG62_08185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KWG62_08190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KWG62_08195	COG0202	RNA polymerase activity
KWG62_08200	COG0203	ribosomal protein L17
KWG62_08205	COG4122	O-methyltransferase activity
KWG62_08280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KWG62_08285	COG0101	tRNA pseudouridine synthase activity
KWG62_08290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KWG62_08295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KWG62_08300	COG3842	ATPase activity
KWG62_08305	COG1175	transmembrane transport
KWG62_08335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KWG62_08345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KWG62_08350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG62_08375	COG0561	phosphatase activity
KWG62_08380	COG0778	Nitroreductase
KWG62_08385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWG62_08390	COG3331	DNA recombination
KWG62_08395	COG3599	regulation of cell shape
KWG62_08430	COG0772	Belongs to the SEDS family
KWG62_08440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWG62_08445	COG0571	ribonuclease III activity
KWG62_08450	COG2176	DNA-directed DNA polymerase activity
KWG62_08460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KWG62_08465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KWG62_08485	COG0126	phosphoglycerate kinase activity
KWG62_08520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KWG62_08530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KWG62_08535	COG4481	Protein conserved in bacteria
KWG62_08540	COG0012	GTP binding
KWG62_08545	COG1994	Peptidase M50
KWG62_08575	COG0559	Belongs to the binding-protein-dependent transport system permease family
KWG62_08585	COG0411	ABC transporter
KWG62_08595	COG0517	IMP dehydrogenase activity
KWG62_08595	COG1125	glycine betaine transport
KWG62_08630	COG0569	domain protein
KWG62_08640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG62_08645	COG0085	RNA polymerase activity
KWG62_08650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KWG62_08690	COG2502	aspartate--ammonia ligase
KWG62_08695	COG0534	Mate efflux family protein
KWG62_08720	COG0028	Belongs to the TPP enzyme family
KWG62_08725	COG0440	acetolactate synthase activity
KWG62_08735	COG0129	dihydroxy-acid dehydratase activity
KWG62_08745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KWG62_08750	COG0251	oxidation-reduction process
KWG62_08795	COG0745	RESPONSE REGULATOR receiver
KWG62_08890	COG1132	(ABC) transporter
KWG62_08895	COG4988	ABC transporter
KWG62_08900	COG0488	(ABC) transporter
KWG62_08915	COG1725	Transcriptional regulator
KWG62_08920	COG1131	(ABC) transporter
KWG62_08935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KWG62_08955	COG1393	Belongs to the ArsC family
KWG62_08965	COG3177	Filamentation induced by cAMP protein fic
KWG62_08970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KWG62_09045	COG0733	neurotransmitter:sodium symporter activity
KWG62_09070	COG1307	EDD domain protein, DegV family
KWG62_09075	COG0360	Binds together with S18 to 16S ribosomal RNA
KWG62_09080	COG0629	single-stranded DNA binding
KWG62_09085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KWG62_09105	COG0464	growth
KWG62_09130	COG3853	Toxic anion resistance protein (TelA)
KWG62_09145	COG2310	stress, protein
KWG62_09150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG62_09165	COG0359	binds to the 23S rRNA
KWG62_09170	COG0305	Participates in initiation and elongation during chromosome replication
KWG62_09195	COG0356	it plays a direct role in the translocation of protons across the membrane
KWG62_09205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KWG62_09210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KWG62_09215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KWG62_09225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KWG62_09235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG62_09260	COG2348	transferase activity, transferring amino-acyl groups
KWG62_09315	COG2003	Belongs to the UPF0758 family
KWG62_09320	COG1792	Involved in formation and maintenance of cell shape
KWG62_09330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_09330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_09335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KWG62_09340	COG0237	dephospho-CoA kinase activity
KWG62_09420	COG0823	Involved in the tonB-independent uptake of proteins
KWG62_09420	COG1506	peptidase
KWG62_09420	COG4946	Tricorn protease homolog
KWG62_09470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWG62_09475	COG0745	RESPONSE REGULATOR receiver
KWG62_09480	COG2205	protein histidine kinase activity
KWG62_09480	COG2770	Histidine kinase
KWG62_09485	COG0673	inositol 2-dehydrogenase activity
KWG62_09490	COG1363	Peptidase, m42
KWG62_09510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KWG62_09515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_09520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG62_09525	COG1120	ATPase activity
KWG62_09555	COG3328	transposase activity
KWG62_09565	COG3328	transposase activity
KWG62_09605	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_09625	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_09650	COG1737	Transcriptional regulator
KWG62_09655	COG0366	Alpha amylase catalytic
KWG62_09660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_09665	COG3716	PTS system mannose fructose sorbose family IID component
KWG62_09675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_09675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_09725	COG1472	Belongs to the glycosyl hydrolase 3 family
KWG62_09755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_09755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_09810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KWG62_09825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KWG62_09845	COG1846	Transcriptional regulator
KWG62_09850	COG0534	Mate efflux family protein
KWG62_09855	COG0110	maltose O-acetyltransferase activity
KWG62_09905	COG0640	Transcriptional regulator
KWG62_09920	COG2217	Heavy metal translocating P-type atpase
KWG62_09940	COG2183	response to ionizing radiation
KWG62_09955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KWG62_09970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KWG62_09985	COG0612	Peptidase, M16
KWG62_10000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KWG62_10005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KWG62_10010	COG1104	cysteine desulfurase activity
KWG62_10015	COG0301	tRNA thio-modification
KWG62_10020	COG2226	methyltransferase
KWG62_10050	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KWG62_10055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KWG62_10095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KWG62_10100	COG1058	Belongs to the CinA family
KWG62_10100	COG1546	Belongs to the CinA family
KWG62_10115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KWG62_10135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KWG62_10140	COG2011	ABC-type metal ion transport system permease component
KWG62_10145	COG1464	Belongs to the NlpA lipoprotein family
KWG62_10150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWG62_10150	COG0116	Belongs to the methyltransferase superfamily
KWG62_10160	COG4821	SIS domain
KWG62_10165	COG0210	DNA helicase
KWG62_10170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KWG62_10180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KWG62_10185	COG0154	amidase activity
KWG62_10190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KWG62_10215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG62_10225	COG1132	(ABC) transporter
KWG62_10230	COG1132	(ABC) transporter
KWG62_10245	COG0668	transmembrane transport
KWG62_10285	COG0436	Aminotransferase
KWG62_10295	COG1595	DNA-templated transcription, initiation
KWG62_10315	COG0534	Mate efflux family protein
KWG62_10325	COG0656	L-ascorbic acid biosynthetic process
KWG62_10330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KWG62_10335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG62_10345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWG62_10345	COG0072	phenylalanine-tRNA ligase activity
KWG62_10370	COG1216	Glycosyl transferase, family 2
KWG62_10375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KWG62_10385	COG0534	Mate efflux family protein
KWG62_10395	COG0228	four-way junction DNA binding
KWG62_10405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KWG62_10420	COG0335	large ribosomal subunit rRNA binding
KWG62_10425	COG0681	Belongs to the peptidase S26 family
KWG62_10435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KWG62_10440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KWG62_10445	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KWG62_10455	COG0052	Belongs to the universal ribosomal protein uS2 family
KWG62_10460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KWG62_10475	COG1151	hydroxylamine reductase activity
KWG62_10490	COG2246	polysaccharide biosynthetic process
KWG62_10505	COG1131	(ABC) transporter
KWG62_10510	COG2188	Transcriptional regulator
KWG62_10565	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KWG62_10565	COG3408	Glycogen debranching enzyme
KWG62_10675	COG0233	cytoplasmic translational termination
KWG62_10680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KWG62_10685	COG0575	Belongs to the CDS family
KWG62_10690	COG0750	zinc metalloprotease
KWG62_10700	COG1272	protein, Hemolysin III
KWG62_10710	COG0552	protein localization to endoplasmic reticulum
KWG62_10720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KWG62_10730	COG0587	DNA-directed DNA polymerase activity
KWG62_10735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KWG62_10740	COG2868	ribosomal protein
KWG62_10745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KWG62_10750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KWG62_10755	COG0463	Glycosyl transferase, family 2
KWG62_10760	COG0708	Exodeoxyribonuclease III
KWG62_10770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KWG62_10780	COG0632	four-way junction helicase activity
KWG62_10785	COG2255	four-way junction helicase activity
KWG62_10790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KWG62_10790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KWG62_10795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KWG62_10800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWG62_10830	COG1323	Belongs to the UPF0348 family
KWG62_10835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG62_10845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KWG62_10850	COG1418	mRNA catabolic process
KWG62_10855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG62_10865	COG1674	ftsk spoiiie
KWG62_10885	COG0187	DNA topoisomerase II activity
KWG62_10890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KWG62_10895	COG3763	UPF0154 protein
KWG62_10910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KWG62_10920	COG2326	polyphosphate kinase activity
KWG62_10955	COG0564	pseudouridine synthase activity
KWG62_10970	COG1193	negative regulation of DNA recombination
KWG62_11030	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG62_11040	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG62_11055	COG2348	transferase activity, transferring amino-acyl groups
KWG62_11060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KWG62_11060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWG62_11065	COG1215	transferase activity, transferring glycosyl groups
KWG62_11075	COG0438	transferase activity, transferring glycosyl groups
KWG62_11075	COG1216	Glycosyl transferase, family 2
KWG62_11090	COG0564	pseudouridine synthase activity
KWG62_11110	COG0564	pseudouridine synthase activity
KWG62_11115	COG2033	superoxide reductase activity
KWG62_11240	COG2984	ABC transporter substrate binding protein
KWG62_11245	COG4120	Belongs to the binding-protein-dependent transport system permease family
KWG62_11250	COG1122	ATPase activity
KWG62_11255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KWG62_11260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KWG62_11265	COG0297	glycogen (starch) synthase activity
KWG62_11275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG62_11285	COG0583	DNA-binding transcription factor activity
KWG62_11295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWG62_11345	COG3250	beta-galactosidase activity
KWG62_11365	COG2197	response regulator
KWG62_11400	COG2207	Transcriptional regulator
KWG62_11400	COG3708	Transcriptional regulator
KWG62_11405	COG1653	transport
KWG62_11420	COG1175	transmembrane transport
KWG62_11425	COG0395	ABC-type sugar transport system, permease component
KWG62_11430	COG3842	ATPase activity
KWG62_11440	COG0205	6-phosphofructokinase activity
KWG62_11505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG62_11555	COG0215	cysteine-tRNA ligase activity
KWG62_11560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KWG62_11565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG62_11575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWG62_11585	COG0250	Participates in transcription elongation, termination and antitermination
KWG62_11590	COG1609	Transcriptional regulator
KWG62_11595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KWG62_11600	COG0647	UMP catabolic process
KWG62_11605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KWG62_11610	COG0557	exoribonuclease II activity
KWG62_11620	COG3591	Belongs to the peptidase S1B family
KWG62_11640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG62_11645	COG1132	(ABC) transporter
KWG62_11660	COG0662	Cupin 2, conserved barrel domain protein
KWG62_11695	COG4120	Belongs to the binding-protein-dependent transport system permease family
KWG62_11700	COG3842	ATPase activity
KWG62_11715	COG1217	gtp-binding protein TYPA
KWG62_11730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KWG62_11735	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KWG62_11745	COG0674	pyruvate-flavodoxin oxidoreductase activity
KWG62_11745	COG1013	pyruvate-flavodoxin oxidoreductase activity
KWG62_11745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KWG62_11745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KWG62_11760	COG3250	beta-galactosidase activity
KWG62_11775	COG0826	peptidase U32
KWG62_11780	COG0442	prolyl-tRNA aminoacylation
KWG62_11850	COG1696	Membrane protein involved in D-alanine export
KWG62_11870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG62_11875	COG0768	penicillin binding
KWG62_11880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWG62_11885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWG62_11890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWG62_11950	COG1131	(ABC) transporter
KWG62_12020	COG1403	HNH endonuclease
KWG62_12075	COG4626	Terminase
KWG62_12075	COG1802	Transcriptional regulator
KWG62_12080	COG3409	Peptidoglycan-binding domain 1 protein
KWG62_12105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KWG62_12105	COG0616	signal peptide processing
KWG62_12220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_12220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_12240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KWG62_12265	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KWG62_12270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KWG62_12275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWG62_12280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KWG62_12310	COG3328	transposase activity
KWG62_12335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_12335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG62_12385	COG0561	phosphatase activity
KWG62_12415	COG3328	transposase activity
KWG62_12430	COG1760	l-serine dehydratase
KWG62_12435	COG0657	acetylesterase activity
KWG62_12440	COG2270	Major facilitator Superfamily
KWG62_12445	COG0495	leucyl-tRNA aminoacylation
KWG62_12495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KWG62_12500	COG0039	L-malate dehydrogenase activity
KWG62_12505	COG3328	transposase activity
KWG62_12515	COG3328	transposase activity
KWG62_12525	COG3328	transposase activity
KWG62_12535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KWG62_12540	COG0352	thiamine-phosphate diphosphorylase activity
KWG62_12545	COG0351	phosphomethylpyrimidine kinase
KWG62_12545	COG0352	thiamine-phosphate diphosphorylase activity
KWG62_12555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KWG62_12620	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KWG62_12630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KWG62_12645	COG0583	DNA-binding transcription factor activity
KWG62_12655	COG4555	ABC transporter
KWG62_12660	COG2814	Major facilitator Superfamily
KWG62_12680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KWG62_12680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KWG62_12685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KWG62_12690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KWG62_12695	COG2843	Capsule synthesis protein
KWG62_12700	COG1242	4 iron, 4 sulfur cluster binding
KWG62_12705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KWG62_12715	COG1799	cell septum assembly
KWG62_12725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KWG62_12730	COG0561	phosphatase activity
KWG62_12765	COG3655	Transcriptional regulator
KWG62_12770	COG4656	Part of a membrane complex involved in electron transport
KWG62_12775	COG4658	electron transport chain
KWG62_12785	COG4660	Part of a membrane complex involved in electron transport
KWG62_12790	COG4657	Part of a membrane complex involved in electron transport
KWG62_12810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG62_12815	COG0423	glycine-tRNA ligase activity
KWG62_12820	COG0358	DNA primase activity
KWG62_12825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWG62_12840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KWG62_12845	COG0513	Belongs to the DEAD box helicase family
KWG62_12850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KWG62_12865	COG0628	permease
KWG62_12880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG62_12885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG62_12885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG62_12890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KWG62_12900	COG0515	serine threonine protein kinase
KWG62_12900	COG2815	serine threonine protein kinase
KWG62_12905	COG1162	GTPase activity
KWG62_12925	COG1028	Short-chain dehydrogenase reductase Sdr
KWG62_12930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KWG62_12940	COG2207	Transcriptional regulator
KWG62_12940	COG1917	Cupin 2, conserved barrel domain protein
KWG62_12945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWG62_12960	COG0180	Tryptophanyl-tRNA synthetase
KWG62_12965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWG62_12965	COG0574	Belongs to the PEP-utilizing enzyme family
KWG62_12970	COG1960	acyl-CoA dehydrogenase activity
KWG62_12985	COG1045	serine acetyltransferase
KWG62_12995	COG1263	PTS System
KWG62_12995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG62_12995	COG2190	(PTS) system
KWG62_13000	COG1609	Transcriptional regulator
KWG62_13010	COG0189	ligase activity
KWG62_13010	COG2918	glutathione biosynthetic process
KWG62_13020	COG0546	phosphoglycolate phosphatase activity
KWG62_13030	COG1691	(AIR) carboxylase