locus-tag	class	description
KWG61_00020	COG3250	beta-galactosidase activity
KWG61_00080	COG3250	beta-galactosidase activity
KWG61_00125	COG0203	ribosomal protein L17
KWG61_00130	COG0202	RNA polymerase activity
KWG61_00140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KWG61_00145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KWG61_00190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KWG61_00245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KWG61_00255	COG0089	rRNA binding
KWG61_00260	COG0088	Forms part of the polypeptide exit tunnel
KWG61_00270	COG0051	transcription antitermination factor activity, RNA binding
KWG61_00290	COG0531	amino acid
KWG61_00295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWG61_00300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG61_00310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KWG61_00315	COG3842	ATPase activity
KWG61_00340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KWG61_00370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG61_00415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWG61_00430	COG0765	amino acid transport
KWG61_00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KWG61_00445	COG3830	Belongs to the UPF0237 family
KWG61_00455	COG0280	phosphate acetyltransferase
KWG61_00475	COG0285	dihydrofolate synthase activity
KWG61_00490	COG3409	Peptidoglycan-binding domain 1 protein
KWG61_00490	COG0793	Belongs to the peptidase S41A family
KWG61_00495	COG0598	Magnesium transport protein CorA
KWG61_00540	COG2801	Transposase and inactivated derivatives
KWG61_00560	COG0419	ATPase involved in DNA repair
KWG61_00575	COG1592	Rubrerythrin
KWG61_00665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KWG61_00680	COG0433	COG0433 Predicted ATPase
KWG61_00690	COG0433	COG0433 Predicted ATPase
KWG61_00700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KWG61_00715	COG2226	methyltransferase
KWG61_00725	COG0799	negative regulation of ribosome biogenesis
KWG61_00730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KWG61_00740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KWG61_00760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KWG61_00765	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KWG61_00770	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KWG61_00795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KWG61_00805	COG0537	adenosine 5'-monophosphoramidase activity
KWG61_00810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KWG61_00855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG61_00865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG61_00875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KWG61_00885	COG2188	Transcriptional regulator
KWG61_00890	COG1131	(ABC) transporter
KWG61_00900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KWG61_00900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KWG61_00905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KWG61_00945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG61_00980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KWG61_01010	COG2738	Putative neutral zinc metallopeptidase
KWG61_01020	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KWG61_01030	COG0352	thiamine-phosphate diphosphorylase activity
KWG61_01080	COG3591	Belongs to the peptidase S1B family
KWG61_01115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG61_01145	COG0534	Mate efflux family protein
KWG61_01150	COG0436	Aminotransferase
KWG61_01165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KWG61_01170	COG4166	transmembrane transport
KWG61_01175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWG61_01180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWG61_01185	COG0110	maltose O-acetyltransferase activity
KWG61_01190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KWG61_01220	COG0802	atpase or kinase
KWG61_01270	COG0747	negative chemotaxis
KWG61_01290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KWG61_01295	COG0477	Major facilitator Superfamily
KWG61_01330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG61_01330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWG61_01330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG61_01370	COG0167	dihydroorotate dehydrogenase activity
KWG61_01375	COG0543	2 iron, 2 sulfur cluster binding
KWG61_01385	COG0505	Belongs to the CarA family
KWG61_01410	COG4535	Mg2 and Co2 transporter CorC
KWG61_01415	COG0534	Mate efflux family protein
KWG61_01450	COG0617	tRNA 3'-terminal CCA addition
KWG61_01465	COG0312	modulator of DNA gyrase
KWG61_01540	COG3250	beta-galactosidase activity
KWG61_01545	COG3250	beta-galactosidase activity
KWG61_01630	COG3481	metal-dependent phosphohydrolase, HD sub domain
KWG61_01645	COG0438	transferase activity, transferring glycosyl groups
KWG61_01770	COG2608	mercury ion transmembrane transporter activity
KWG61_01775	COG2217	Heavy metal translocating P-type atpase
KWG61_01800	COG1176	ABC-type spermidine putrescine transport system, permease component I
KWG61_01835	COG2367	Beta-lactamase
KWG61_01885	COG2252	PERMEase
KWG61_01890	COG1074	ATP-dependent DNA helicase activity
KWG61_01895	COG1074	ATP-dependent DNA helicase activity
KWG61_01925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG61_01935	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KWG61_01945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KWG61_01960	COG0037	tRNA processing
KWG61_01995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWG61_02010	COG5002	protein histidine kinase activity
KWG61_02045	COG1696	Membrane protein involved in D-alanine export
KWG61_02080	COG4821	SIS domain
KWG61_02085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KWG61_02090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KWG61_02125	COG0024	Methionine aminopeptidase
KWG61_02145	COG0084	hydrolase, TatD family'
KWG61_02190	COG0562	UDP-galactopyranose mutase
KWG61_02210	COG1192	Involved in chromosome partitioning
KWG61_02225	COG3343	RNA polymerase activity
KWG61_02245	COG1078	dGTPase activity
KWG61_02250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KWG61_02285	COG0594	ribonuclease P activity
KWG61_02290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KWG61_02305	COG2501	S4 domain
KWG61_02310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KWG61_02400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWG61_02405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWG61_02415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KWG61_02450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KWG61_02510	COG0726	polysaccharide deacetylase
KWG61_02520	COG0151	Belongs to the GarS family
KWG61_02550	COG0534	Mate efflux family protein
KWG61_02575	COG1396	sequence-specific DNA binding
KWG61_02580	COG1116	anion transmembrane transporter activity
KWG61_02585	COG3842	ATPase activity
KWG61_02625	COG0493	'glutamate synthase
KWG61_02640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KWG61_02685	COG1307	EDD domain protein, DegV family
KWG61_02720	COG3118	belongs to the thioredoxin family
KWG61_02725	COG0791	NLP P60 protein
KWG61_02725	COG0741	lytic transglycosylase activity
KWG61_02750	COG3118	belongs to the thioredoxin family
KWG61_02755	COG1012	belongs to the aldehyde dehydrogenase family
KWG61_02785	COG1555	photosystem II stabilization
KWG61_02830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG61_02860	COG2176	DNA-directed DNA polymerase activity
KWG61_02885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWG61_02905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWG61_02910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWG61_02915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWG61_02925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KWG61_02960	COG1640	4-alpha-glucanotransferase
KWG61_02970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KWG61_02975	COG1733	regulation of RNA biosynthetic process
KWG61_03040	COG1496	oxidoreductase activity
KWG61_03070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KWG61_03095	COG1732	Glycine betaine
KWG61_03115	COG1609	Transcriptional regulator
KWG61_03170	COG3842	ATPase activity
KWG61_03205	COG0463	Glycosyl transferase, family 2
KWG61_03210	COG0463	Glycosyl transferase, family 2
KWG61_03215	COG1442	glycosyl transferase family 8
KWG61_03215	COG1216	Glycosyl transferase, family 2
KWG61_03230	COG1215	transferase activity, transferring glycosyl groups
KWG61_03275	COG1114	Component of the transport system for branched-chain amino acids
KWG61_03285	COG1114	Component of the transport system for branched-chain amino acids
KWG61_03300	COG1473	amidohydrolase
KWG61_03305	COG0019	diaminopimelate decarboxylase activity
KWG61_03310	COG0019	diaminopimelate decarboxylase activity
KWG61_03315	COG0019	diaminopimelate decarboxylase activity
KWG61_03320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KWG61_03325	COG0454	-acetyltransferase
KWG61_03385	COG1609	Transcriptional regulator
KWG61_03425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWG61_03445	COG1396	sequence-specific DNA binding
KWG61_03485	COG4608	Belongs to the ABC transporter superfamily
KWG61_03500	COG0601	transmembrane transport
KWG61_03505	COG4166	transmembrane transport
KWG61_03570	COG1263	PTS System
KWG61_03570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG61_03580	COG1621	beta-fructofuranosidase activity
KWG61_03585	COG1621	beta-fructofuranosidase activity
KWG61_03595	COG1609	Transcriptional regulator
KWG61_03770	COG2205	protein histidine kinase activity
KWG61_03785	COG0742	ribosomal rna small subunit methyltransferase
KWG61_03800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KWG61_03805	COG0768	penicillin binding
KWG61_03815	COG2001	Belongs to the MraZ family
KWG61_03830	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
KWG61_03845	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
KWG61_03855	COG1518	maintenance of DNA repeat elements
KWG61_03860	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KWG61_03925	COG1739	Uncharacterized protein family UPF0029
KWG61_03935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG61_03980	COG2357	RelA SpoT domain protein
KWG61_04000	COG0561	phosphatase activity
KWG61_04020	COG1194	a g-specific adenine glycosylase
KWG61_04025	COG0561	phosphatase activity
KWG61_04190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KWG61_04205	COG0577	efflux transmembrane transporter activity
KWG61_04215	COG0698	ribose 5-phosphate isomerase
KWG61_04230	COG1979	alcohol dehydrogenase
KWG61_04250	COG1979	alcohol dehydrogenase
KWG61_04400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KWG61_04415	COG0514	ATP-dependent DNA helicase (RecQ)
KWG61_04440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KWG61_04515	COG1879	ABC-type sugar transport system periplasmic component
KWG61_04525	COG4211	Belongs to the binding-protein-dependent transport system permease family
KWG61_04570	COG1051	belongs to the nudix hydrolase family
KWG61_04575	COG1321	iron dependent repressor
KWG61_04580	COG0826	peptidase U32
KWG61_04595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG61_04600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KWG61_04615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KWG61_04685	COG2003	Belongs to the UPF0758 family
KWG61_04710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KWG61_04715	COG0237	dephospho-CoA kinase activity
KWG61_04795	COG2801	Transposase and inactivated derivatives
KWG61_04805	COG0581	inorganic phosphate transmembrane transporter activity
KWG61_04815	COG0573	inorganic phosphate transmembrane transporter activity
KWG61_04910	COG1506	peptidase
KWG61_04910	COG4946	Tricorn protease homolog
KWG61_04910	COG0823	Involved in the tonB-independent uptake of proteins
KWG61_04955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KWG61_04960	COG0561	phosphatase activity
KWG61_05010	COG2843	Capsule synthesis protein
KWG61_05025	COG1335	isochorismatase
KWG61_05070	COG3250	beta-galactosidase activity
KWG61_05095	COG0640	Transcriptional regulator
KWG61_05105	COG2217	Heavy metal translocating P-type atpase
KWG61_05125	COG2183	response to ionizing radiation
KWG61_05135	COG2183	response to ionizing radiation
KWG61_05145	COG2183	response to ionizing radiation
KWG61_05150	COG2183	response to ionizing radiation
KWG61_05155	COG2183	response to ionizing radiation
KWG61_05195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KWG61_05275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG61_05390	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KWG61_05490	COG3250	beta-galactosidase activity
KWG61_05495	COG3250	beta-galactosidase activity
KWG61_05545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KWG61_05550	COG2011	ABC-type metal ion transport system permease component
KWG61_05595	COG1876	peptidase activity
KWG61_05625	COG4821	SIS domain
KWG61_05630	COG0210	DNA helicase
KWG61_05700	COG3250	beta-galactosidase activity
KWG61_05790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWG61_05850	COG0668	transmembrane transport
KWG61_05970	COG0656	L-ascorbic acid biosynthetic process
KWG61_05980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KWG61_05990	COG3583	domain protein
KWG61_05990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG61_05990	COG3064	Membrane
KWG61_05995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG61_06055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KWG61_06075	COG0335	large ribosomal subunit rRNA binding
KWG61_06080	COG1234	tRNA 3'-trailer cleavage
KWG61_06085	COG0681	Belongs to the peptidase S26 family
KWG61_06110	COG4974	Belongs to the 'phage' integrase family
KWG61_06125	COG2246	polysaccharide biosynthetic process
KWG61_06130	COG4821	SIS domain
KWG61_06160	COG0561	phosphatase activity
KWG61_06180	COG0789	Transcriptional regulator
KWG61_06230	COG4555	ABC transporter
KWG61_06240	COG0233	cytoplasmic translational termination
KWG61_06250	COG0575	Belongs to the CDS family
KWG61_06275	COG1196	nuclear chromosome segregation
KWG61_06280	COG1196	nuclear chromosome segregation
KWG61_06285	COG1196	nuclear chromosome segregation
KWG61_06320	COG0587	DNA-directed DNA polymerase activity
KWG61_06325	COG0587	DNA-directed DNA polymerase activity
KWG61_06340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KWG61_06345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KWG61_06355	COG5434	Belongs to the glycosyl hydrolase 28 family
KWG61_06365	COG4886	Leucine-rich repeat (LRR) protein
KWG61_06395	COG0632	four-way junction helicase activity
KWG61_06400	COG2255	four-way junction helicase activity
KWG61_06410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KWG61_06410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KWG61_06460	COG3561	AntA/AntB antirepressor
KWG61_06690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG61_06690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG61_06780	COG1472	Belongs to the glycosyl hydrolase 3 family
KWG61_06810	COG1323	Belongs to the UPF0348 family
KWG61_06815	COG1323	Belongs to the UPF0348 family
KWG61_06820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWG61_06825	COG1399	metal-binding, possibly nucleic acid-binding protein
KWG61_06830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KWG61_06900	COG3763	UPF0154 protein
KWG61_07000	COG1484	DNA-dependent DNA replication
KWG61_07005	COG3328	transposase activity
KWG61_07010	COG3328	transposase activity
KWG61_07040	COG4499	WXG100 protein secretion system (Wss), protein YukC
KWG61_07040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWG61_07050	COG2326	polyphosphate kinase activity
KWG61_07090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KWG61_07095	COG0564	pseudouridine synthase activity
KWG61_07115	COG1193	negative regulation of DNA recombination
KWG61_07125	COG1876	peptidase activity
KWG61_07155	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG61_07190	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWG61_07230	COG1063	alcohol dehydrogenase
KWG61_07235	COG1105	Belongs to the carbohydrate kinase PfkB family
KWG61_07240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG61_07245	COG3711	transcriptional antiterminator
KWG61_07245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG61_07290	COG1215	transferase activity, transferring glycosyl groups
KWG61_07300	COG0438	transferase activity, transferring glycosyl groups
KWG61_07300	COG1216	Glycosyl transferase, family 2
KWG61_07345	COG2264	protein methyltransferase activity
KWG61_07425	COG2033	superoxide reductase activity
KWG61_07455	COG4120	Belongs to the binding-protein-dependent transport system permease family
KWG61_07470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KWG61_07475	COG0297	glycogen (starch) synthase activity
KWG61_07490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG61_07555	COG0443	Heat shock 70 kDa protein
KWG61_07570	COG3655	Transcriptional regulator
KWG61_07720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWG61_07745	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KWG61_07750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWG61_07770	COG0250	Participates in transcription elongation, termination and antitermination
KWG61_07780	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KWG61_07785	COG0647	UMP catabolic process
KWG61_07800	COG3591	Belongs to the peptidase S1B family
KWG61_07820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWG61_07910	COG3842	ATPase activity
KWG61_07975	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KWG61_08005	COG2801	Transposase and inactivated derivatives
KWG61_08040	COG3250	beta-galactosidase activity
KWG61_08050	COG2017	converts alpha-aldose to the beta-anomer
KWG61_08140	COG0534	Mate efflux family protein
KWG61_08155	COG1696	Membrane protein involved in D-alanine export
KWG61_08445	COG5632	N-Acetylmuramoyl-L-alanine amidase
KWG61_08445	COG3409	Peptidoglycan-binding domain 1 protein
KWG61_08465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG61_08475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWG61_08480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWG61_08490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWG61_08505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWG61_08605	COG4279	zinc finger
KWG61_08610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KWG61_08615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KWG61_08640	COG0039	L-malate dehydrogenase activity
KWG61_08650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KWG61_08720	COG1242	4 iron, 4 sulfur cluster binding
KWG61_08725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KWG61_08745	COG1799	cell septum assembly
KWG61_08775	COG1773	rubredoxin
KWG61_08785	COG1477	protein flavinylation
KWG61_08815	COG4660	Part of a membrane complex involved in electron transport
KWG61_08875	COG0436	Aminotransferase
KWG61_08880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG61_08900	COG0358	DNA primase activity
KWG61_08930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KWG61_08955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KWG61_08985	COG0628	permease
KWG61_09015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG61_09020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG61_09025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWG61_09030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG61_09030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG61_09035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG61_09035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG61_09075	COG1609	Transcriptional regulator
KWG61_09085	COG0662	Cupin 2, conserved barrel domain protein
KWG61_09095	COG0515	serine threonine protein kinase
KWG61_09095	COG2815	serine threonine protein kinase
KWG61_09105	COG1162	GTPase activity
KWG61_09115	COG1564	THIamine pyrophosphokinase
KWG61_09135	COG1028	Short-chain dehydrogenase reductase Sdr
KWG61_09275	COG0494	nUDIX hydrolase
KWG61_09340	COG1595	DNA-templated transcription, initiation
KWG61_09345	COG0493	'glutamate synthase
KWG61_09365	COG2190	(PTS) system
KWG61_09365	COG1263	PTS System
KWG61_09365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG61_09370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG61_09370	COG1263	PTS System
KWG61_09375	COG2190	(PTS) system
KWG61_09375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG61_09375	COG1263	PTS System
KWG61_09405	COG0174	glutamine synthetase
KWG61_09415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWG61_09465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KWG61_09465	COG0493	'glutamate synthase
KWG61_09475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWG61_09510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KWG61_09520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KWG61_09530	COG0765	amino acid transport
KWG61_09620	COG3250	beta-galactosidase activity
KWG61_09625	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KWG61_09665	COG1373	ATPase (AAA superfamily
KWG61_09670	COG2801	Transposase and inactivated derivatives
KWG61_09690	COG3436	PFAM IS66 Orf2 family protein
KWG61_09760	COG1748	Saccharopine dehydrogenase
KWG61_09770	COG0561	phosphatase activity
KWG61_09840	COG0668	transmembrane transport
KWG61_09885	COG1447	Phosphotransferase system cellobiose-specific component IIA
KWG61_09895	COG2188	Transcriptional regulator
KWG61_09940	COG4974	Belongs to the 'phage' integrase family
KWG61_09960	COG0497	DNA recombination
KWG61_10005	COG1570	exodeoxyribonuclease VII activity
KWG61_10010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWG61_10020	COG0196	riboflavin kinase activity
KWG61_10030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KWG61_10035	COG0037	tRNA processing
KWG61_10055	COG3885	ferrous iron binding
KWG61_10055	COG2078	PFAM AMMECR1 domain protein
KWG61_10070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KWG61_10080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWG61_10100	COG1187	pseudouridine synthase activity
KWG61_10110	COG0860	N-Acetylmuramoyl-L-alanine amidase
KWG61_10115	COG0494	nUDIX hydrolase
KWG61_10120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KWG61_10130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KWG61_10175	COG1024	Enoyl-CoA hydratase
KWG61_10190	COG2086	electron transfer activity
KWG61_10200	COG0183	Belongs to the thiolase family
KWG61_10285	COG0195	Participates in both transcription termination and antitermination
KWG61_10290	COG0195	Participates in both transcription termination and antitermination
KWG61_10295	COG0779	Required for maturation of 30S ribosomal subunits
KWG61_10300	COG0194	GDP metabolic process
KWG61_10325	COG3385	transposase activity
KWG61_10350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KWG61_10355	COG1609	Transcriptional regulator
KWG61_10390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWG61_10435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KWG61_10440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KWG61_10450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWG61_10455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWG61_10485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KWG61_10490	COG3906	Belongs to the UPF0473 family
KWG61_10510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWG61_10515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWG61_10520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWG61_10550	COG1648	precorrin-2 dehydrogenase activity
KWG61_10550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG61_10555	COG1648	precorrin-2 dehydrogenase activity
KWG61_10555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWG61_10565	COG1120	ATPase activity
KWG61_10570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_10575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_10675	COG1523	belongs to the glycosyl hydrolase 13 family
KWG61_10685	COG0114	fumarate hydratase activity
KWG61_10705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWG61_10710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KWG61_10720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KWG61_10745	COG0655	NAD(P)H dehydrogenase (quinone) activity
KWG61_10995	COG0582	viral genome integration into host DNA
KWG61_11060	COG2205	protein histidine kinase activity
KWG61_11070	COG2211	Major facilitator Superfamily
KWG61_11085	COG3250	beta-galactosidase activity
KWG61_11125	COG5002	protein histidine kinase activity
KWG61_11140	COG0745	RESPONSE REGULATOR receiver
KWG61_11145	COG0745	RESPONSE REGULATOR receiver
KWG61_11150	COG1283	sodium-dependent phosphate transmembrane transporter activity
KWG61_11160	COG0800	Aldolase
KWG61_11165	COG1904	glucuronate isomerase
KWG61_11170	COG0789	Transcriptional regulator
KWG61_11220	COG0561	phosphatase activity
KWG61_11240	COG2239	Acts as a magnesium transporter
KWG61_11265	COG3328	transposase activity
KWG61_11270	COG3328	transposase activity
KWG61_11285	COG1247	-acetyltransferase
KWG61_11315	COG0124	histidyl-tRNA synthetase
KWG61_11470	COG2801	Transposase and inactivated derivatives
KWG61_11555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KWG61_11565	COG0138	bifunctional purine biosynthesis protein purh
KWG61_11570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KWG61_11585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KWG61_11605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KWG61_11620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KWG61_11705	COG0588	phosphoglycerate mutase activity
KWG61_11735	COG0778	Nitroreductase
KWG61_11755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KWG61_11760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_11765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_11775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_11780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KWG61_11785	COG1120	ATPase activity
KWG61_11790	COG1120	ATPase activity
KWG61_11905	COG2205	protein histidine kinase activity
KWG61_11940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KWG61_11945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KWG61_11960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWG61_11975	COG0124	histidyl-tRNA synthetase
KWG61_11980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWG61_12030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWG61_12080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG61_12085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG61_12115	COG0363	glucosamine-6-phosphate deaminase activity
KWG61_12150	COG3715	PTS system
KWG61_12155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KWG61_12195	COG2222	sugar isomerase
KWG61_12205	COG0560	Phosphoserine phosphatase
KWG61_12265	COG0424	maF-like protein
KWG61_12315	COG0083	homoserine kinase activity
KWG61_12320	COG0083	homoserine kinase activity
KWG61_12330	COG0460	homoserine dehydrogenase
KWG61_12335	COG0460	homoserine dehydrogenase
KWG61_12340	COG0527	aspartate kinase activity
KWG61_12345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KWG61_12395	COG1410	methionine synthase
KWG61_12395	COG0646	methionine synthase
KWG61_12445	COG1278	Cold shock
KWG61_12465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KWG61_12485	COG0719	Fe-S assembly protein
KWG61_12495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWG61_12650	COG0483	inositol monophosphate 1-phosphatase activity
KWG61_12945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KWG61_12960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KWG61_12960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWG61_12965	COG0739	heme binding
KWG61_13025	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KWG61_13045	COG1028	Short-chain dehydrogenase reductase Sdr
KWG61_13135	COG3436	PFAM IS66 Orf2 family protein
KWG61_13195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KWG61_13210	COG0569	domain protein
KWG61_13215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG61_13220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG61_13225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG61_13290	COG1725	Transcriptional regulator
KWG61_13310	COG1126	abc transporter atp-binding protein
KWG61_13315	COG0765	amino acid transport
KWG61_13415	COG0210	DNA helicase
KWG61_13435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWG61_13490	COG1316	TRANSCRIPTIONal
KWG61_13530	COG0446	pyridine nucleotide-disulphide oxidoreductase
KWG61_13545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KWG61_13575	COG1773	rubredoxin
KWG61_13575	COG0426	domain, Protein
KWG61_13715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KWG61_13720	COG0009	L-threonylcarbamoyladenylate synthase
KWG61_13725	COG0009	L-threonylcarbamoyladenylate synthase
KWG61_13785	COG1131	(ABC) transporter
KWG61_13790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWG61_13805	COG0740	serine-type endopeptidase activity
KWG61_13845	COG0457	Tetratricopeptide repeat
KWG61_13845	COG0515	serine threonine protein kinase
KWG61_13905	COG3716	PTS system mannose fructose sorbose family IID component
KWG61_13910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWG61_13920	COG1737	Transcriptional regulator
KWG61_13940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KWG61_14025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG61_14030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWG61_14045	COG1484	DNA-dependent DNA replication
KWG61_14115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG61_14115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWG61_14230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KWG61_14265	COG0356	it plays a direct role in the translocation of protons across the membrane
KWG61_14285	COG1234	tRNA 3'-trailer cleavage
KWG61_14300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KWG61_14375	COG1307	EDD domain protein, DegV family
KWG61_14395	COG0577	efflux transmembrane transporter activity
KWG61_14450	COG0469	pyruvate kinase activity
KWG61_14460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KWG61_14465	COG3177	Filamentation induced by cAMP protein fic
KWG61_14470	COG1393	Belongs to the ArsC family
KWG61_14480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KWG61_14535	COG0488	(ABC) transporter
KWG61_14540	COG4988	ABC transporter
KWG61_14545	COG4988	ABC transporter
KWG61_14550	COG1132	(ABC) transporter
KWG61_14555	COG1132	(ABC) transporter
KWG61_14560	COG1132	(ABC) transporter
KWG61_14565	COG1132	(ABC) transporter
KWG61_14575	COG0202	RNA polymerase activity
KWG61_14585	COG1077	Cell shape determining protein MreB Mrl
KWG61_14630	COG0745	RESPONSE REGULATOR receiver
KWG61_14635	COG0745	RESPONSE REGULATOR receiver
KWG61_14685	COG1368	sulfuric ester hydrolase activity
KWG61_14690	COG0251	oxidation-reduction process
KWG61_14805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG61_14815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KWG61_14820	COG0569	domain protein
KWG61_14850	COG0366	Alpha amylase catalytic
KWG61_14865	COG0411	ABC transporter
KWG61_14925	COG0012	GTP binding
KWG61_14930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KWG61_14950	COG0778	Nitroreductase
KWG61_15025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWG61_15030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWG61_15045	COG0772	Belongs to the SEDS family
KWG61_15080	COG1696	Membrane protein involved in D-alanine export
KWG61_15100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KWG61_15105	COG2720	vancomycin resistance protein
KWG61_15135	COG3599	regulation of cell shape
KWG61_15145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWG61_15145	COG4499	WXG100 protein secretion system (Wss), protein YukC
KWG61_15195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KWG61_15215	COG1484	DNA-dependent DNA replication
KWG61_15235	COG0745	RESPONSE REGULATOR receiver
KWG61_15255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KWG61_15290	COG3250	beta-galactosidase activity