locus-tag	class	description
Atep_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Atep_00020	COG0592	DNA-directed DNA polymerase activity
Atep_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Atep_00060	COG1136	(ABC) transporter
Atep_00210	COG3706	GGDEF domain
Atep_00220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Atep_00240	COG3956	TIGRFAM MazG family protein
Atep_00260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Atep_00320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Atep_00330	COG0436	Aminotransferase
Atep_00340	COG2171	N-acyltransferase activity
Atep_00350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Atep_00360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Atep_00370	COG2894	cell division
Atep_00380	COG0850	regulation of cytokinetic process
Atep_00390	COG0537	adenosine 5'-monophosphoramidase activity
Atep_00400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Atep_00410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Atep_00420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Atep_00430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Atep_00440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Atep_00510	COG0372	Belongs to the citrate synthase family
Atep_00520	COG0281	malic enzyme
Atep_00530	COG0254	rRNA binding
Atep_00540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Atep_00550	COG0539	negative regulation of cytoplasmic translation
Atep_00570	COG0210	DNA helicase
Atep_00580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Atep_00590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Atep_00590	COG3153	acetyltransferase
Atep_00620	COG0037	tRNA processing
Atep_00640	COG2205	protein histidine kinase activity
Atep_00640	COG2202	Pas domain
Atep_00670	COG0714	Associated with various cellular activities
Atep_00680	COG0445	tRNA wobble uridine modification
Atep_00700	COG0840	transmembrane signaling receptor activity
Atep_00700	COG0840	transmembrane signaling receptor activity
Atep_00720	COG0737	Belongs to the 5'-nucleotidase family
Atep_00740	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Atep_00750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Atep_00760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Atep_00770	COG2363	Small membrane protein
Atep_00780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Atep_00790	COG0784	Response regulator, receiver
Atep_00790	COG0643	Histidine kinase
Atep_00790	COG2198	Histidine kinase
Atep_00800	COG0840	transmembrane signaling receptor activity
Atep_00850	COG0189	ligase activity
Atep_00870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Atep_00880	COG1678	Uncharacterized ACR, COG1678
Atep_00890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Atep_00910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Atep_00920	COG0540	Belongs to the ATCase OTCase family
Atep_00950	COG1151	hydroxylamine reductase activity
Atep_00970	COG0003	Pfam Anion-transporting ATPase
Atep_00990	COG0724	RNA recognition motif
Atep_01000	COG0513	Belongs to the DEAD box helicase family
Atep_01020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Atep_01030	COG2084	Dehydrogenase
Atep_01050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Atep_01060	COG1074	ATP-dependent DNA helicase activity
Atep_01130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atep_01180	COG0018	arginyl-trna synthetase
Atep_01190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Atep_01210	COG3001	Fructosamine kinase
Atep_01270	COG0675	Transposase, IS605 OrfB family
Atep_01280	COG4969	Belongs to the N-Me-Phe pilin family
Atep_01320	COG1216	Glycosyl transferase, family 2
Atep_01340	COG4591	ABC-type transport system involved in lipoprotein release permease component
Atep_01370	COG2333	competence protein COMEC
Atep_01370	COG0658	competence protein
Atep_01400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Atep_01420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Atep_01430	COG4206	TonB-dependent receptor
Atep_01460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Atep_01470	COG3028	Belongs to the UPF0307 family
Atep_01540	COG1959	2 iron, 2 sulfur cluster binding
Atep_01550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Atep_01570	COG1560	Kdo2-lipid A biosynthetic process
Atep_01580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Atep_01630	COG0513	Belongs to the DEAD box helicase family
Atep_01650	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Atep_01650	COG2755	lipolytic protein G-D-S-L family
Atep_01680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Atep_01700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Atep_01730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Atep_01740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Atep_01750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Atep_01760	COG1054	Belongs to the UPF0176 family
Atep_01780	COG4942	peptidase
Atep_01790	COG0793	Belongs to the peptidase S41A family
Atep_01830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atep_01840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Atep_01850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Atep_01900	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Atep_01920	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Atep_01960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Atep_01960	COG0574	Belongs to the PEP-utilizing enzyme family
Atep_02000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_02000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_02150	COG0702	epimerase
Atep_02170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Atep_02240	COG3706	GGDEF domain
Atep_02260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Atep_02300	COG1490	D-aminoacyl-tRNA deacylase activity
Atep_02310	COG0596	Alpha beta hydrolase
Atep_02320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Atep_02350	COG3243	poly(R)-hydroxyalkanoic acid synthase
Atep_02370	COG0183	Belongs to the thiolase family
Atep_02380	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Atep_02410	COG1028	Short-chain dehydrogenase reductase Sdr
Atep_02430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Atep_02440	COG0723	plastoquinol--plastocyanin reductase activity
Atep_02450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Atep_02460	COG2857	Cytochrome c1
Atep_02470	COG0625	glutathione transferase activity
Atep_02480	COG2969	positive regulation of protein catabolic process
Atep_02570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Atep_02720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Atep_02730	COG0352	thiamine-phosphate diphosphorylase activity
Atep_02750	COG0351	phosphomethylpyrimidine kinase
Atep_02760	COG1773	rubredoxin
Atep_02790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Atep_02800	COG0316	Belongs to the HesB IscA family
Atep_02820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Atep_02880	COG0494	nUDIX hydrolase
Atep_02890	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Atep_02900	COG0277	FAD linked oxidase domain protein
Atep_02910	COG2823	Periplasmic or secreted lipoprotein
Atep_02920	COG0792	nuclease activity
Atep_02930	COG3107	peptidoglycan biosynthetic process
Atep_02940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Atep_02950	COG2001	Belongs to the MraZ family
Atep_02960	COG0275	rRNA processing
Atep_02970	COG3116	cell division
Atep_02990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Atep_03000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Atep_03010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Atep_03020	COG0772	Belongs to the SEDS family
Atep_03030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Atep_03040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Atep_03050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Atep_03060	COG1181	Belongs to the D-alanine--D-alanine ligase family
Atep_03070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Atep_03100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Atep_03120	COG4942	peptidase
Atep_03130	COG0653	protein targeting
Atep_03140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Atep_03150	COG0494	nUDIX hydrolase
Atep_03200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Atep_03210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Atep_03230	COG0217	transcriptional regulatory protein
Atep_03240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Atep_03250	COG0632	four-way junction helicase activity
Atep_03280	COG0277	FAD linked oxidase domain protein
Atep_03290	COG0247	lactate metabolic process
Atep_03310	COG0237	dephospho-CoA kinase activity
Atep_03340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atep_03360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Atep_03420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Atep_03430	COG0134	indole-3-glycerol-phosphate synthase activity
Atep_03440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Atep_03450	COG1765	OsmC-like protein
Atep_03460	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Atep_03470	COG0247	lactate metabolic process
Atep_03490	COG1459	type II secretion system
Atep_03510	COG4970	Tfp pilus assembly protein FimT
Atep_03520	COG2165	general secretion pathway protein
Atep_03540	COG3156	type II secretion system protein K
Atep_03550	COG1716	ATPase activity
Atep_03550	COG1131	(ABC) transporter
Atep_03550	COG0842	Transport permease protein
Atep_03600	COG1450	Type ii and iii secretion system protein
Atep_03620	COG0070	glutamate synthase
Atep_03620	COG0069	glutamate synthase activity
Atep_03620	COG0067	glutamate synthase
Atep_03680	COG5001	Diguanylate cyclase
Atep_03680	COG3300	MHYT domain
Atep_03690	COG1301	dicarboxylic acid transport
Atep_03700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Atep_03740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atep_03750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Atep_03760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Atep_03770	COG0215	cysteine-tRNA ligase activity
Atep_03880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atep_03890	COG2815	serine threonine protein kinase
Atep_03890	COG0515	serine threonine protein kinase
Atep_03950	COG4771	TonB-dependent receptor
Atep_03970	COG2146	nitrite reductase [NAD(P)H] activity
Atep_03980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Atep_04010	COG0825	malonyl-CoA metabolic process
Atep_04020	COG0037	tRNA processing
Atep_04030	COG5002	protein histidine kinase activity
Atep_04030	COG2205	protein histidine kinase activity
Atep_04030	COG0784	Response regulator, receiver
Atep_04040	COG0357	Ribosomal RNA small subunit methyltransferase G
Atep_04050	COG1192	Involved in chromosome partitioning
Atep_04060	COG1475	DNA binding
Atep_04080	COG0356	it plays a direct role in the translocation of protons across the membrane
Atep_04100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Atep_04110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Atep_04120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Atep_04140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Atep_04150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Atep_04160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Atep_04250	COG3118	belongs to the thioredoxin family
Atep_04260	COG3118	belongs to the thioredoxin family
Atep_04270	COG0505	Belongs to the CarA family
Atep_04280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Atep_04290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Atep_04330	COG0300	oxidoreductase activity
Atep_04380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Atep_04390	COG0494	nUDIX hydrolase
Atep_04400	COG1132	(ABC) transporter
Atep_04420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Atep_04430	COG1530	ribonuclease E activity
Atep_04450	COG0546	phosphoglycolate phosphatase activity
Atep_04460	COG0616	signal peptide processing
Atep_04490	COG0745	RESPONSE REGULATOR receiver
Atep_04500	COG5002	protein histidine kinase activity
Atep_04540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Atep_04550	COG4106	trans-aconitate 2-methyltransferase activity
Atep_04560	COG0500	methyltransferase
Atep_04590	COG0719	Fe-S assembly protein
Atep_04600	COG0396	ATPase activity
Atep_04610	COG0719	Fe-S assembly protein
Atep_04620	COG2151	metal-sulfur cluster biosynthetic enzyme
Atep_04680	COG3885	ferrous iron binding
Atep_04680	COG2078	PFAM AMMECR1 domain protein
Atep_04690	COG1355	regulation of microtubule-based process
Atep_04710	COG0741	lytic transglycosylase activity
Atep_04730	COG0730	response to heat
Atep_04760	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Atep_04790	COG0596	Alpha beta hydrolase
Atep_04800	COG1469	GTP cyclohydrolase I activity
Atep_04810	COG0142	geranyltranstransferase activity
Atep_04820	COG1722	exodeoxyribonuclease VII activity
Atep_04830	COG0187	DNA topoisomerase II activity
Atep_04850	COG0268	Binds directly to 16S ribosomal RNA
Atep_04860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Atep_04890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Atep_04900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Atep_04920	COG3278	Belongs to the heme-copper respiratory oxidase family
Atep_04960	COG0348	domain, Protein
Atep_04980	COG2217	Heavy metal translocating P-type atpase
Atep_05030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_05040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atep_05070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Atep_05070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Atep_05100	COG0564	pseudouridine synthase activity
Atep_05120	COG3830	Belongs to the UPF0237 family
Atep_05130	COG0242	peptide deformylase activity
Atep_05150	COG2918	glutathione biosynthetic process
Atep_05160	COG0248	Ppx GppA phosphatase
Atep_05180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Atep_05190	COG0508	dehydrogenase complex catalyzes the overall conversion of
Atep_05220	COG0343	queuine tRNA-ribosyltransferase activity
Atep_05230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Atep_05240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atep_05250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Atep_05260	COG3178	'Phosphotransferase
Atep_05310	COG0151	Belongs to the GarS family
Atep_05320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atep_05330	COG0138	bifunctional purine biosynthesis protein purh
Atep_05350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Atep_05410	COG2264	protein methyltransferase activity
Atep_05500	COG2154	pterin-4-alpha-carbinolamine dehydratase
Atep_05540	COG0438	transferase activity, transferring glycosyl groups
Atep_05580	COG0297	glycogen (starch) synthase activity
Atep_05600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Atep_05630	COG0758	DNA mediated transformation
Atep_05700	COG0644	oxidoreductase
Atep_05710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Atep_05740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Atep_05750	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Atep_05760	COG1429	ligase activity, forming nitrogen-metal bonds
Atep_05770	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Atep_05830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Atep_05910	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Atep_05930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Atep_05970	COG0840	transmembrane signaling receptor activity
Atep_05980	COG2201	protein-glutamate methylesterase activity
Atep_06020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Atep_06030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Atep_06040	COG0408	coproporphyrinogen oxidase activity
Atep_06050	COG0438	transferase activity, transferring glycosyl groups
Atep_06080	COG0312	modulator of DNA gyrase
Atep_06090	COG3830	Belongs to the UPF0237 family
Atep_06090	COG0560	Phosphoserine phosphatase
Atep_06140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atep_06150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Atep_06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atep_06190	COG2201	protein-glutamate methylesterase activity
Atep_06200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Atep_06230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Atep_06240	COG0741	lytic transglycosylase activity
Atep_06260	COG3047	cAMP biosynthetic process
Atep_06260	COG2885	chlorophyll binding
Atep_06280	COG1294	oxidase, subunit
Atep_06290	COG1271	oxidase subunit
Atep_06330	COG0488	(ABC) transporter
Atep_06350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Atep_06370	COG0243	molybdopterin cofactor binding
Atep_06380	COG0437	4 iron, 4 sulfur cluster binding
Atep_06390	COG3302	dmso reductase anchor subunit
Atep_06420	COG0750	zinc metalloprotease
Atep_06450	COG0826	peptidase U32
Atep_06460	COG2983	Belongs to the UPF0260 family
Atep_06470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Atep_06480	COG4974	Belongs to the 'phage' integrase family
Atep_06490	COG1666	GTP binding
Atep_06500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Atep_06510	COG0631	protein serine/threonine phosphatase activity
Atep_06520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Atep_06610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Atep_06630	COG0438	transferase activity, transferring glycosyl groups
Atep_06660	COG0573	inorganic phosphate transmembrane transporter activity
Atep_06680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Atep_06690	COG0704	Plays a role in the regulation of phosphate uptake
Atep_06710	COG1388	LysM domain
Atep_06710	COG0741	lytic transglycosylase activity
Atep_06730	COG0328	RNA-DNA hybrid ribonuclease activity
Atep_06750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Atep_06760	COG0504	CTP synthase activity
Atep_06770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Atep_06780	COG3093	addiction module antidote protein HigA
Atep_06790	COG0148	phosphopyruvate hydratase activity
Atep_06800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Atep_06810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Atep_06820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Atep_06830	COG0585	pseudouridine synthase activity
Atep_06840	COG0745	RESPONSE REGULATOR receiver
Atep_06900	COG0724	RNA recognition motif
Atep_06910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Atep_06920	COG0339	signal peptide processing
Atep_06960	COG4566	intracellular signal transduction
Atep_06970	COG3706	GGDEF domain
Atep_06980	COG0191	fructose-bisphosphate aldolase activity
Atep_06990	COG0469	pyruvate kinase activity
Atep_07000	COG0126	phosphoglycerate kinase activity
Atep_07010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Atep_07020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Atep_07040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Atep_07100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Atep_07110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Atep_07120	COG2211	Major facilitator Superfamily
Atep_07150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Atep_07160	COG1477	protein flavinylation
Atep_07170	COG4658	electron transport chain
Atep_07180	COG4657	Part of a membrane complex involved in electron transport
Atep_07190	COG0142	geranyltranstransferase activity
Atep_07200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Atep_07220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Atep_07270	COG0419	ATPase involved in DNA repair
Atep_07320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Atep_07400	COG1160	GTP binding
Atep_07410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atep_07420	COG2976	Protein conserved in bacteria
Atep_07430	COG0124	histidyl-tRNA synthetase
Atep_07460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Atep_07470	COG0105	UTP biosynthetic process
Atep_07500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Atep_07520	COG0557	exoribonuclease II activity
Atep_07530	COG3108	Peptidase M15
Atep_07560	COG0243	molybdopterin cofactor binding
Atep_07660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Atep_07680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atep_07710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Atep_07730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Atep_07820	COG0784	Response regulator, receiver
Atep_07820	COG2205	protein histidine kinase activity
Atep_07820	COG5002	protein histidine kinase activity
Atep_07860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Atep_07920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Atep_07970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Atep_07970	COG1328	CTP reductase activity
Atep_08010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Atep_08020	COG0284	orotidine-5'-phosphate decarboxylase activity
Atep_08090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atep_08100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Atep_08110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Atep_08130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Atep_08140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Atep_08210	COG1136	(ABC) transporter
Atep_08210	COG0577	efflux transmembrane transporter activity
Atep_08260	COG2205	protein histidine kinase activity
Atep_08260	COG2198	Histidine kinase
Atep_08260	COG0784	Response regulator, receiver
Atep_08270	COG4585	Histidine kinase
Atep_08280	COG2197	response regulator
Atep_08300	COG0826	peptidase U32
Atep_08310	COG0826	peptidase U32
Atep_08320	COG1242	4 iron, 4 sulfur cluster binding
Atep_08330	COG0840	transmembrane signaling receptor activity
Atep_08420	COG3550	peptidyl-serine autophosphorylation
Atep_08450	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Atep_08470	COG0542	response to heat
Atep_08480	COG3409	Peptidoglycan-binding domain 1 protein
Atep_08480	COG3267	Type II secretory pathway component ExeA
Atep_08500	COG2239	Acts as a magnesium transporter
Atep_08510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Atep_08590	COG2205	protein histidine kinase activity
Atep_08640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Atep_08670	COG0497	DNA recombination
Atep_08680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Atep_08690	COG1420	regulation of RNA biosynthetic process
Atep_08700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Atep_08710	COG0443	Heat shock 70 kDa protein
Atep_08720	COG0484	heat shock protein binding
Atep_08750	COG2354	Protein conserved in bacteria
Atep_08760	COG3154	lipid carrier protein
Atep_08800	COG3706	GGDEF domain
Atep_08800	COG5001	Diguanylate cyclase
Atep_08800	COG2203	Gaf domain
Atep_08800	COG4251	negative regulation of phosphorylation
Atep_08830	COG0443	Heat shock 70 kDa protein
Atep_08850	COG3123	guanosine phosphorylase activity
Atep_08860	COG2255	four-way junction helicase activity
Atep_08910	COG0277	FAD linked oxidase domain protein
Atep_08970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Atep_08980	COG0303	'Molybdopterin
Atep_08990	COG0521	Mo-molybdopterin cofactor biosynthetic process
Atep_09000	COG0129	dihydroxy-acid dehydratase activity
Atep_09010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Atep_09040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Atep_09080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Atep_09100	COG0418	dihydroorotase activity
Atep_09160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Atep_09180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Atep_09230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Atep_09240	COG0149	triose-phosphate isomerase activity
Atep_09260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_09270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_09280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_09290	COG0649	NAD binding
Atep_09300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Atep_09320	COG1034	ATP synthesis coupled electron transport
Atep_09330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Atep_09340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_09360	COG0713	ATP synthesis coupled electron transport
Atep_09390	COG1007	ATP synthesis coupled electron transport
Atep_09400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Atep_09410	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Atep_09420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Atep_09430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Atep_09440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Atep_09460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Atep_09470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Atep_09480	COG1472	Belongs to the glycosyl hydrolase 3 family
Atep_09490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Atep_09500	COG5007	Belongs to the BolA IbaG family
Atep_09510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Atep_09520	COG0165	Argininosuccinate lyase
Atep_09540	COG4953	penicillin-binding protein 1C
Atep_09560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Atep_09590	COG1011	Hydrolase
Atep_09620	COG0857	belongs to the CobB CobQ family
Atep_09620	COG0280	phosphate acetyltransferase
Atep_09630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Atep_09650	COG1881	PFAM PEBP family protein
Atep_09670	COG3088	subunit of a heme lyase
Atep_09670	COG4235	cytochrome complex assembly
Atep_09680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Atep_09700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Atep_09720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Atep_09730	COG0827	DNA restriction-modification system
Atep_09740	COG0827	DNA restriction-modification system
Atep_09760	COG4133	protoheme IX ABC transporter activity
Atep_09770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Atep_09770	COG0116	Belongs to the methyltransferase superfamily
Atep_09800	COG3437	response regulator, receiver
Atep_09800	COG3850	Histidine kinase
Atep_09800	COG4999	Histidine kinase
Atep_09800	COG2205	protein histidine kinase activity
Atep_09820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Atep_09830	COG3162	membrane
Atep_09910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Atep_09910	COG2205	protein histidine kinase activity
Atep_09920	COG0505	Belongs to the CarA family
Atep_09940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Atep_09950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Atep_09970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Atep_10050	COG0577	efflux transmembrane transporter activity
Atep_10050	COG1136	(ABC) transporter
Atep_10070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Atep_10070	COG0515	serine threonine protein kinase
Atep_10090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Atep_10140	COG2304	oxidoreductase activity
Atep_10210	COG0567	Dehydrogenase, E1 component
Atep_10300	COG0840	transmembrane signaling receptor activity
Atep_10410	COG0628	permease
Atep_10420	COG0501	Belongs to the peptidase M48B family
Atep_10430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Atep_10440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Atep_10450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Atep_10460	COG0509	glycine decarboxylation via glycine cleavage system
Atep_10470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Atep_10490	COG0495	leucyl-tRNA aminoacylation
Atep_10500	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Atep_10530	COG0012	GTP binding
Atep_10540	COG0516	GMP reductase activity
Atep_10540	COG0517	IMP dehydrogenase activity
Atep_10560	COG3328	transposase activity
Atep_10620	COG0071	Belongs to the small heat shock protein (HSP20) family
Atep_10650	COG0501	Belongs to the peptidase M48B family
Atep_10660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Atep_10750	COG0789	Transcriptional regulator
Atep_10800	COG0798	PFAM Bile acid sodium symporter
Atep_10820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Atep_10830	COG0640	Transcriptional regulator
Atep_10850	COG4232	protein-disulfide reductase activity
Atep_10930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Atep_10950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Atep_10970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Atep_10980	COG1013	pyruvate-flavodoxin oxidoreductase activity
Atep_10980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Atep_10980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Atep_10980	COG0674	pyruvate-flavodoxin oxidoreductase activity
Atep_10990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Atep_11040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Atep_11090	COG2005	Transcriptional regulator
Atep_11090	COG3585	molybdate ion transport
Atep_11140	COG0730	response to heat
Atep_11180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Atep_11190	COG0840	transmembrane signaling receptor activity
Atep_11220	COG0243	molybdopterin cofactor binding
Atep_11250	COG1803	Methylglyoxal synthase
Atep_11280	COG0489	protein tyrosine kinase activity
Atep_11330	COG4191	Histidine kinase
Atep_11340	COG2204	response regulator
Atep_11350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Atep_11470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atep_11530	COG0363	glucosamine-6-phosphate deaminase activity
Atep_11550	COG4067	protein conserved in archaea
Atep_11550	COG0189	ligase activity
Atep_11570	COG1295	ribonuclease BN
Atep_11640	COG1690	Belongs to the RtcB family
Atep_11680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atep_11690	COG2379	hydroxypyruvate reductase
Atep_11710	COG1214	PFAM Peptidase M22, glycoprotease
Atep_11730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Atep_11750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Atep_11760	COG4988	ABC transporter
Atep_11770	COG0228	four-way junction DNA binding
Atep_11780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Atep_11790	COG0336	Belongs to the RNA methyltransferase TrmD family
Atep_11800	COG0335	large ribosomal subunit rRNA binding
Atep_11810	COG2925	Exonuclease
Atep_11840	COG3443	Belongs to the bacterial solute-binding protein 9 family
Atep_11840	COG0803	Belongs to the bacterial solute-binding protein 9 family
Atep_11880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Atep_11890	COG0583	DNA-binding transcription factor activity
Atep_11930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atep_11940	COG0735	belongs to the Fur family
Atep_11970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Atep_11980	COG0745	RESPONSE REGULATOR receiver
Atep_11990	COG0643	Histidine kinase
Atep_11990	COG2198	Histidine kinase
Atep_12020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Atep_12090	COG0084	hydrolase, TatD family'
Atep_12110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Atep_12130	COG1492	cobalamin metabolic process
Atep_12140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Atep_12150	COG1605	Chorismate mutase
Atep_12150	COG0077	Prephenate dehydratase
Atep_12160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Atep_12170	COG0287	Prephenate dehydrogenase
Atep_12180	COG1763	Mo-molybdopterin cofactor biosynthetic process
Atep_12190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Atep_12200	COG0569	domain protein
Atep_12210	COG2204	response regulator
Atep_12220	COG5000	phosphorelay sensor kinase activity
Atep_12240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Atep_12240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Atep_12250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Atep_12260	COG0242	peptide deformylase activity
Atep_12270	COG1652	LysM domain
Atep_12280	COG0758	DNA mediated transformation
Atep_12300	COG2922	Belongs to the Smg family
Atep_12370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Atep_12400	COG5002	protein histidine kinase activity
Atep_12400	COG0784	Response regulator, receiver
Atep_12400	COG2205	protein histidine kinase activity
Atep_12420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Atep_12430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Atep_12480	COG0415	Belongs to the DNA photolyase family
Atep_12490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Atep_12500	COG0386	Belongs to the glutathione peroxidase family
Atep_12520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Atep_12530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Atep_12580	COG0195	Participates in both transcription termination and antitermination
Atep_12590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Atep_12600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Atep_12610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Atep_12620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Atep_12630	COG1185	polyribonucleotide nucleotidyltransferase activity
Atep_12640	COG2308	Evidence 4 Homologs of previously reported genes of
Atep_12660	COG0864	Transcriptional regulator
Atep_12760	COG0310	cobalt ion transport
Atep_12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atep_12810	COG2027	D-alanyl-D-alanine carboxypeptidase
Atep_12820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Atep_12830	COG2226	methyltransferase
Atep_12850	COG0156	8-amino-7-oxononanoate synthase activity
Atep_12860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Atep_12870	COG1040	competence protein
Atep_12900	COG0714	Associated with various cellular activities
Atep_12910	COG1217	gtp-binding protein TYPA
Atep_12940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Atep_12970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Atep_12980	COG0081	regulation of translation
Atep_12990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Atep_13000	COG0222	ribosome binding
Atep_13010	COG0085	RNA polymerase activity
Atep_13020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Atep_13030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Atep_13050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Atep_13060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Atep_13070	COG0051	transcription antitermination factor activity, RNA binding
Atep_13080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Atep_13090	COG0088	Forms part of the polypeptide exit tunnel
Atep_13100	COG0089	rRNA binding
Atep_13110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Atep_13120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Atep_13130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Atep_13140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Atep_13150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Atep_13160	COG0255	Belongs to the universal ribosomal protein uL29 family
Atep_13170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Atep_13180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Atep_13190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Atep_13200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Atep_13210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Atep_13230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Atep_13240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Atep_13250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Atep_13260	COG1841	ribosomal large subunit assembly
Atep_13270	COG0200	Binds to the 23S rRNA
Atep_13280	COG0201	protein transport
Atep_13290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Atep_13300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Atep_13310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Atep_13320	COG0202	RNA polymerase activity
Atep_13330	COG0203	ribosomal protein L17
Atep_13350	COG0513	Belongs to the DEAD box helicase family
Atep_13400	COG2133	pyrroloquinoline quinone binding
Atep_13430	COG0137	argininosuccinate synthase activity
Atep_13470	COG0004	ammonium transporteR
Atep_13500	COG2960	long-chain fatty acid transporting porin activity
Atep_13570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Atep_13580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Atep_13590	COG0492	ferredoxin-NADP+ reductase activity
Atep_13600	COG0791	NLP P60 protein
Atep_13630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Atep_13650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Atep_13660	COG2867	negative regulation of translational initiation
Atep_13680	COG3706	GGDEF domain
Atep_13690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Atep_13690	COG1776	CheC inhibitor of MCP methylation
Atep_13700	COG2201	protein-glutamate methylesterase activity
Atep_13710	COG1720	tRNA m6t6A37 methyltransferase activity
Atep_13720	COG0517	IMP dehydrogenase activity
Atep_13720	COG0617	tRNA 3'-terminal CCA addition
Atep_13720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Atep_13730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Atep_13730	COG3620	sequence-specific DNA binding
Atep_13730	COG0617	tRNA 3'-terminal CCA addition
Atep_13790	COG1177	transmembrane transport
Atep_13800	COG1176	ABC-type spermidine putrescine transport system, permease component I
Atep_13810	COG3842	ATPase activity
Atep_13820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Atep_13850	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Atep_13850	COG2878	Part of a membrane complex involved in electron transport
Atep_13860	COG0674	pyruvate-flavodoxin oxidoreductase activity
Atep_13860	COG1013	pyruvate-flavodoxin oxidoreductase activity
Atep_13860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Atep_13860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Atep_13870	COG4656	Part of a membrane complex involved in electron transport
Atep_13880	COG4658	electron transport chain
Atep_13900	COG4660	Part of a membrane complex involved in electron transport
Atep_13910	COG4657	Part of a membrane complex involved in electron transport
Atep_13930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Atep_13940	COG0196	riboflavin kinase activity
Atep_13950	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Atep_14000	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Atep_14030	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Atep_14060	COG0590	tRNA wobble adenosine to inosine editing
Atep_14120	COG0443	Heat shock 70 kDa protein
Atep_14130	COG0297	glycogen (starch) synthase activity
Atep_14140	COG0366	Alpha amylase catalytic
Atep_14180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Atep_14190	COG2716	regulation of RNA biosynthetic process
Atep_14230	COG0360	Binds together with S18 to 16S ribosomal RNA
Atep_14260	COG0359	binds to the 23S rRNA
Atep_14280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Atep_14290	COG3273	potassium ion transport
Atep_14290	COG0471	metal ion transport
Atep_14320	COG0189	ligase activity
Atep_14330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Atep_14440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Atep_14450	COG3437	response regulator, receiver
Atep_14460	COG2226	methyltransferase
Atep_14490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Atep_14500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Atep_14530	COG1216	Glycosyl transferase, family 2
Atep_14540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atep_14590	COG1053	succinate dehydrogenase
Atep_14630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Atep_14640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Atep_14700	COG2221	Nitrite and sulphite reductase 4Fe-4S
Atep_14710	COG2221	Nitrite and sulphite reductase 4Fe-4S
Atep_14720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Atep_14730	COG2923	Belongs to the DsrF TusC family
Atep_14750	COG2920	part of a sulfur-relay system
Atep_14820	COG1797	cobyrinic acid a,c-diamide synthase activity
Atep_14870	COG0424	maF-like protein
Atep_14880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Atep_14900	COG3844	kynureninase activity
Atep_14920	COG1410	methionine synthase
Atep_14920	COG0646	methionine synthase
Atep_14950	COG0367	asparagine synthase
Atep_14990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atep_15000	COG0746	molybdenum cofactor guanylyltransferase activity
Atep_15010	COG1331	Highly conserved protein containing a thioredoxin domain
Atep_15030	COG4181	ATPase activity
Atep_15070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Atep_15080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Atep_15090	COG1862	Preprotein translocase
Atep_15120	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Atep_15130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Atep_15160	COG1643	Atp-dependent helicase
Atep_15170	COG3338	carbonate dehydratase activity
Atep_15220	COG1408	metallophosphoesterase
Atep_15240	COG3842	ATPase activity
Atep_15280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Atep_15320	COG1131	(ABC) transporter
Atep_15330	COG0842	Transport permease protein
Atep_15340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Atep_15360	COG2046	Belongs to the sulfate adenylyltransferase family
Atep_15410	COG1047	Peptidyl-prolyl cis-trans
Atep_15420	COG0009	L-threonylcarbamoyladenylate synthase
Atep_15430	COG0583	DNA-binding transcription factor activity
Atep_15500	COG0529	Catalyzes the synthesis of activated sulfate
Atep_15510	COG1199	ATP-dependent helicase activity
Atep_15560	COG1121	(ABC) transporter
Atep_15570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Atep_15600	COG0514	ATP-dependent DNA helicase (RecQ)
Atep_15610	COG3954	Phosphoribulokinase
Atep_15630	COG4660	Part of a membrane complex involved in electron transport
Atep_15640	COG4659	FMN binding
Atep_15650	COG4658	electron transport chain
Atep_15660	COG0259	pyridoxamine-phosphate oxidase activity
Atep_15680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Atep_15680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Atep_15700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Atep_15710	COG5265	(ABC) transporter
Atep_15730	COG1286	toxin biosynthetic process
Atep_15760	COG3260	NADH ubiquinone oxidoreductase 20
Atep_15770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Atep_15780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Atep_15810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Atep_15820	COG0717	Belongs to the dCTP deaminase family
Atep_15820	COG0717	Belongs to the dCTP deaminase family
Atep_15840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Atep_15850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Atep_15870	COG0776	regulation of translation
Atep_15880	COG5002	protein histidine kinase activity
Atep_15940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Atep_15950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Atep_15960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Atep_15990	COG1254	Belongs to the acylphosphatase family
Atep_16000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Atep_16020	COG1028	Short-chain dehydrogenase reductase Sdr
Atep_16040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Atep_16050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Atep_16060	COG0308	aminopeptidase N
Atep_16140	COG2204	response regulator
Atep_16160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Atep_16200	COG0824	Thioesterase
Atep_16220	COG2373	Large extracellular alpha-helical protein
Atep_16240	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Atep_16260	COG0542	response to heat
Atep_16270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Atep_16280	COG1278	Cold shock
Atep_16300	COG2211	Major facilitator Superfamily
Atep_16310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Atep_16320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Atep_16330	COG3437	response regulator, receiver
Atep_16340	COG0280	phosphate acetyltransferase
Atep_16340	COG0281	malic enzyme
Atep_16350	COG4536	flavin adenine dinucleotide binding
Atep_16360	COG2974	May be involved in recombination
Atep_16380	COG2878	Part of a membrane complex involved in electron transport
Atep_16390	COG4657	Part of a membrane complex involved in electron transport
Atep_16410	COG0651	ATP synthesis coupled electron transport
Atep_16420	COG0651	ATP synthesis coupled electron transport
Atep_16530	COG0640	Transcriptional regulator
Atep_16590	COG0463	Glycosyl transferase, family 2
Atep_16610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Atep_16650	COG0123	including yeast histone deacetylase and acetoin utilization protein
Atep_16660	COG0045	succinate-CoA ligase (ADP-forming) activity
Atep_16660	COG1042	CoA-binding domain protein
Atep_16660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Atep_16700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Atep_16710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atep_16730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Atep_16750	COG0840	transmembrane signaling receptor activity
Atep_16750	COG3290	protein histidine kinase activity
Atep_16780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Atep_16800	COG2201	protein-glutamate methylesterase activity
Atep_16810	COG0840	transmembrane signaling receptor activity
Atep_16820	COG0183	Belongs to the thiolase family
Atep_16930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Atep_16940	COG0735	belongs to the Fur family
Atep_17090	COG0729	surface antigen
Atep_17110	COG1560	Kdo2-lipid A biosynthetic process
Atep_17140	COG1196	nuclear chromosome segregation
Atep_17150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Atep_17160	COG0318	PFAM AMP-dependent synthetase and ligase
Atep_17180	COG0058	SHG alpha-glucan phosphorylase activity
Atep_17190	COG0045	succinate-CoA ligase (ADP-forming) activity
Atep_17200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Atep_17210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Atep_17220	COG2920	part of a sulfur-relay system
Atep_17280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Atep_17290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Atep_17310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Atep_17400	COG4636	protein conserved in cyanobacteria
Atep_17410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Atep_17420	COG3263	regulation of cellular component size
Atep_17430	COG1028	Short-chain dehydrogenase reductase Sdr
Atep_17450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Atep_17470	COG2199	diguanylate cyclase activity
Atep_17470	COG2200	EAL domain
Atep_17470	COG2203	Gaf domain
Atep_17480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Atep_17490	COG0446	pyridine nucleotide-disulphide oxidoreductase
Atep_17510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Atep_17540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Atep_17550	COG2967	ApaG domain
Atep_17570	COG0673	inositol 2-dehydrogenase activity
Atep_17610	COG2208	phosphoserine phosphatase activity
Atep_17610	COG2770	Histidine kinase
Atep_17630	COG1301	dicarboxylic acid transport
Atep_17650	COG1366	Belongs to the anti-sigma-factor antagonist family
Atep_17670	COG1538	Outer membrane efflux protein
Atep_17680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Atep_17690	COG2814	Major facilitator Superfamily
Atep_17730	COG0297	glycogen (starch) synthase activity
Atep_17750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Atep_17770	COG0436	Aminotransferase
Atep_17790	COG1968	undecaprenyl-diphosphatase activity
Atep_17830	COG2183	response to ionizing radiation
Atep_17870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Atep_17890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Atep_17900	COG2137	regulation of response to DNA damage stimulus
Atep_17910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Atep_17910	COG1372	Participates in initiation and elongation during chromosome replication
Atep_17920	COG1546	Belongs to the CinA family
Atep_17960	COG0511	ligase activity, forming carbon-carbon bonds
Atep_17960	COG5016	pyruvate
Atep_17970	COG0439	Biotin carboxylase
Atep_17990	COG0322	excinuclease ABC activity
Atep_18020	COG1283	sodium-dependent phosphate transmembrane transporter activity
Atep_18050	COG2954	triphosphatase activity
Atep_18060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Atep_18070	COG0670	Belongs to the BI1 family
Atep_18130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Atep_18140	COG1160	GTP binding
Atep_18160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Atep_18170	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Atep_18190	COG0330	HflC and HflK could
Atep_18200	COG0330	HflC and HflK could
Atep_18210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Atep_18220	COG1923	regulation of RNA biosynthetic process
Atep_18230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Atep_18240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Atep_18250	COG0860	N-Acetylmuramoyl-L-alanine amidase
Atep_18260	COG0802	atpase or kinase
Atep_18270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Atep_18270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Atep_18290	COG0442	prolyl-tRNA aminoacylation
Atep_18300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Atep_18320	COG3437	response regulator, receiver
Atep_18340	COG0617	tRNA 3'-terminal CCA addition
Atep_18420	COG1528	Iron-storage protein
Atep_18450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Atep_18450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Atep_18530	COG4467	Involved in initiation control of chromosome replication
Atep_18540	COG0436	Aminotransferase
Atep_18550	COG0556	nucleotide-excision repair
Atep_18580	COG1573	uracil-dna glycosylase
Atep_18590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Atep_18600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Atep_18640	COG0517	IMP dehydrogenase activity
Atep_18730	COG2226	methyltransferase
Atep_18730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Atep_18730	COG0596	Alpha beta hydrolase
Atep_18750	COG2111	Na H antiporter
Atep_18750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atep_18760	COG0650	Formate hydrogenlyase subunit 4
Atep_18790	COG3328	transposase activity
Atep_18800	COG3328	transposase activity
Atep_18810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_18820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_18850	COG0704	Plays a role in the regulation of phosphate uptake
Atep_18870	COG0651	ATP synthesis coupled electron transport
Atep_18880	COG0650	Formate hydrogenlyase subunit 4
Atep_18900	COG0651	ATP synthesis coupled electron transport
Atep_18910	COG0649	NAD binding
Atep_18910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atep_18920	COG4535	Mg2 and Co2 transporter CorC
Atep_18930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Atep_18940	COG1702	phosphate starvation-inducible protein PhoH
Atep_18950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atep_18960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Atep_19000	COG0402	S-adenosylhomocysteine deaminase activity
Atep_19010	COG0688	phosphatidylethanolamine metabolic process
Atep_19030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Atep_19070	COG3045	CreA protein
Atep_19080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Atep_19100	COG2719	SpoVR family
Atep_19110	COG2718	Belongs to the UPF0229 family
Atep_19120	COG2766	serine protein kinase
Atep_19130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Atep_19140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Atep_19170	COG1519	Transferase
Atep_19180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Atep_19190	COG1381	Involved in DNA repair and RecF pathway recombination
Atep_19210	COG0571	ribonuclease III activity
Atep_19230	COG0681	Belongs to the peptidase S26 family
Atep_19240	COG0481	GTPase activity
Atep_19250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atep_19330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Atep_19340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_19360	COG1022	Amp-dependent synthetase and ligase
Atep_19370	COG1194	a g-specific adenine glycosylase
Atep_19380	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Atep_19400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Atep_19410	COG0557	exoribonuclease II activity
Atep_19430	COG1366	Belongs to the anti-sigma-factor antagonist family
Atep_19470	COG0285	dihydrofolate synthase activity
Atep_19570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Atep_19580	COG0159	tryptophan synthase activity
Atep_19590	COG0133	tryptophan synthase activity
Atep_19600	COG0135	phosphoribosylanthranilate isomerase activity
Atep_19610	COG0101	tRNA pseudouridine synthase activity
Atep_19640	COG0473	3-isopropylmalate dehydrogenase activity
Atep_19670	COG0066	3-isopropylmalate dehydratase activity
Atep_19680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Atep_19730	COG0275	rRNA processing
Atep_19740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atep_19870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Atep_19900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Atep_19910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Atep_19910	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Atep_19920	COG0726	polysaccharide deacetylase
Atep_19930	COG0482	sulfurtransferase activity
Atep_19940	COG2915	High frequency lysogenization protein hflD homolog
Atep_19970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Atep_20000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Atep_20020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Atep_20060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Atep_20060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Atep_20070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Atep_20080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Atep_20100	COG2267	carboxylic ester hydrolase activity
Atep_20120	COG1663	tetraacyldisaccharide 4'-kinase activity
Atep_20130	COG1132	(ABC) transporter
Atep_20150	COG0811	peptide transport
Atep_20190	COG1643	Atp-dependent helicase
Atep_20240	COG0019	diaminopimelate decarboxylase activity
Atep_20260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Atep_20280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Atep_20450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Atep_20470	COG1598	PFAM Uncharacterised protein family UPF0150
Atep_20490	COG0574	Belongs to the PEP-utilizing enzyme family
Atep_20490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Atep_20500	COG0525	valine-tRNA ligase activity
Atep_20530	COG3864	Putative metallopeptidase domain
Atep_20540	COG4783	chaperone-mediated protein folding
Atep_20570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Atep_20580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Atep_20590	COG1162	GTPase activity
Atep_20630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Atep_20690	COG1053	succinate dehydrogenase
Atep_20790	COG5001	Diguanylate cyclase
Atep_20800	COG2217	Heavy metal translocating P-type atpase
Atep_20810	COG1797	cobyrinic acid a,c-diamide synthase activity
Atep_20820	COG0616	signal peptide processing
Atep_20830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Atep_20840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Atep_20850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Atep_20850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Atep_20860	COG1511	domain protein
Atep_20860	COG3264	Mechanosensitive ion channel
Atep_20890	COG0084	hydrolase, TatD family'
Atep_20900	COG3122	Protein conserved in bacteria
Atep_20930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Atep_20950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Atep_20980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Atep_21010	COG1183	phosphatidylcholine synthase activity
Atep_21020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Atep_21040	COG3383	formate dehydrogenase (NAD+) activity
Atep_21050	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Atep_21060	COG3259	Nickel-dependent hydrogenase
Atep_21140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Atep_21160	COG0675	Transposase, IS605 OrfB family
Atep_21190	COG0675	Transposase, IS605 OrfB family
Atep_21240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Atep_21280	COG0463	Glycosyl transferase, family 2
Atep_21290	COG0446	pyridine nucleotide-disulphide oxidoreductase
Atep_21300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Atep_21310	COG1674	ftsk spoiiie
Atep_21340	COG0783	Belongs to the Dps family
Atep_21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Atep_21380	COG0601	transmembrane transport
Atep_21410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atep_21430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Atep_21440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Atep_21450	COG0740	serine-type endopeptidase activity
Atep_21460	COG0544	peptidyl-prolyl cis-trans isomerase activity
Atep_21490	COG1959	2 iron, 2 sulfur cluster binding
Atep_21510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Atep_21520	COG0563	adenylate kinase activity
Atep_21530	COG0326	Molecular chaperone. Has ATPase activity
Atep_21540	COG0033	Phosphoglucomutase
Atep_21550	COG0071	Belongs to the small heat shock protein (HSP20) family
Atep_21560	COG0019	diaminopimelate decarboxylase activity
Atep_21590	COG0708	Exodeoxyribonuclease III
Atep_21630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Atep_21640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Atep_21650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Atep_21660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Atep_21690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Atep_21700	COG0416	fatty acid biosynthetic process
Atep_21710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Atep_21730	COG4566	intracellular signal transduction
Atep_21840	COG0714	Associated with various cellular activities
Atep_21920	COG3030	protein affecting phage T7 exclusion by the F plasmid
Atep_21930	COG1324	tolerance protein
Atep_21940	COG4232	protein-disulfide reductase activity
Atep_21950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Atep_21960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Atep_21970	COG0511	ligase activity, forming carbon-carbon bonds
Atep_21980	COG0439	Biotin carboxylase
Atep_22000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Atep_22010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Atep_22120	COG1269	ATP hydrolysis coupled proton transport
Atep_22150	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Atep_22160	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Atep_22200	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Atep_22220	COG1394	ATPase activity, coupled to movement of substances
Atep_22230	COG4251	negative regulation of phosphorylation
Atep_22260	COG5001	Diguanylate cyclase
Atep_22260	COG5002	protein histidine kinase activity
Atep_22280	COG1115	amino acid carrier protein
Atep_22290	COG2917	probably involved in intracellular septation
Atep_22300	COG2350	Protein conserved in bacteria
Atep_22310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atep_22330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Atep_22390	COG2835	tetraacyldisaccharide 4'-kinase activity
Atep_22400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Atep_22440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Atep_22470	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Atep_22520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Atep_22540	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Atep_22550	COG0024	Methionine aminopeptidase
Atep_22560	COG0052	Belongs to the universal ribosomal protein uS2 family
Atep_22570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Atep_22580	COG0528	UMP kinase activity
Atep_22590	COG0233	cytoplasmic translational termination
Atep_22600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Atep_22640	COG4691	Plasmid stability protein
Atep_22670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atep_22690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atep_22700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Atep_22710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atep_22740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Atep_22760	COG0671	phosphoesterase, PA-phosphatase related
Atep_22770	COG0745	RESPONSE REGULATOR receiver
Atep_22780	COG0704	Plays a role in the regulation of phosphate uptake
Atep_22820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Atep_22830	COG1160	GTP binding
Atep_22840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Atep_22900	COG0489	protein tyrosine kinase activity
Atep_22910	COG0675	Transposase, IS605 OrfB family
Atep_22990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Atep_23000	COG3005	denitrification pathway
Atep_23020	COG2863	cytochrome
Atep_23030	COG0446	pyridine nucleotide-disulphide oxidoreductase
Atep_23040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Atep_23050	COG1444	tRNA N-acetyltransferase activity
Atep_23090	COG0193	aminoacyl-tRNA hydrolase activity
Atep_23100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Atep_23110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Atep_23120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Atep_23140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Atep_23150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Atep_23200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Atep_23220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Atep_23240	COG1705	Flagellar rod assembly protein muramidase FlgJ
Atep_23240	COG3951	Flagellar rod assembly protein muramidase FlgJ
Atep_23250	COG1706	bacterial-type flagellum-dependent cell motility
Atep_23260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Atep_23270	COG4786	Flagellar basal body rod
Atep_23300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Atep_23310	COG1558	bacterial-type flagellum-dependent cell motility
Atep_23320	COG1815	bacterial-type flagellum-dependent cell motility
Atep_23330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Atep_23340	COG0835	chemotaxis
Atep_23340	COG0784	Response regulator, receiver
Atep_23440	COG1857	crispr-associated protein
Atep_23480	COG1518	maintenance of DNA repeat elements
Atep_23490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Atep_23510	COG4566	intracellular signal transduction
Atep_23520	COG4191	Histidine kinase
Atep_23540	COG0795	lipopolysaccharide-transporting ATPase activity
Atep_23550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Atep_23560	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Atep_23590	COG0488	(ABC) transporter
Atep_23620	COG0508	dehydrogenase complex catalyzes the overall conversion of
Atep_23620	COG0596	Alpha beta hydrolase
Atep_23630	COG1169	isochorismate synthase
Atep_23640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Atep_23670	COG1487	ribonuclease activity
Atep_23680	COG4456	Virulence-associated protein
Atep_23700	COG1575	Belongs to the MenA family. Type 1 subfamily
Atep_23710	COG4948	Mandelate Racemase Muconate Lactonizing
Atep_23730	COG3459	Glycosyltransferase 36 associated
Atep_23750	COG4178	(ABC) transporter
Atep_23760	COG2723	6-phospho-beta-galactosidase activity
Atep_23790	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Atep_23820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Atep_23930	COG0586	Pfam SNARE associated Golgi protein
Atep_23940	COG0733	neurotransmitter:sodium symporter activity
Atep_23950	COG1686	Belongs to the peptidase S11 family
Atep_23960	COG1187	pseudouridine synthase activity
Atep_23970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Atep_23990	COG0180	Tryptophanyl-tRNA synthetase
Atep_24000	COG1994	Peptidase M50
Atep_24010	COG0009	L-threonylcarbamoyladenylate synthase
Atep_24020	COG0613	PHP domain protein
Atep_24060	COG0588	phosphoglycerate mutase activity
Atep_24090	COG2703	oxygen carrier activity
Atep_24110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Atep_24110	COG0519	Catalyzes the synthesis of GMP from XMP
Atep_24120	COG0516	GMP reductase activity
Atep_24120	COG0517	IMP dehydrogenase activity
Atep_24130	COG1570	exodeoxyribonuclease VII activity
Atep_24140	COG0488	(ABC) transporter
Atep_24170	COG0058	SHG alpha-glucan phosphorylase activity
Atep_24180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Atep_24210	COG0204	Acyl-transferase
Atep_24210	COG0318	PFAM AMP-dependent synthetase and ligase
Atep_24250	COG1216	Glycosyl transferase, family 2
Atep_24270	COG0438	transferase activity, transferring glycosyl groups
Atep_24300	COG0438	transferase activity, transferring glycosyl groups
Atep_24400	COG0693	protein deglycase activity
Atep_24410	COG0167	dihydroorotate dehydrogenase activity
Atep_24440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Atep_24450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Atep_24470	COG2022	thiamine diphosphate biosynthetic process
Atep_24480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Atep_24490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Atep_24500	COG0390	transport system, permease component
Atep_24510	COG0579	oxidoreductase
Atep_24520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Atep_24550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Atep_24580	COG0840	transmembrane signaling receptor activity
Atep_24620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Atep_24630	COG2813	Specifically methylates the guanine in position
Atep_24640	COG0298	carbon dioxide binding
Atep_24680	COG0583	DNA-binding transcription factor activity
Atep_24700	COG0140	phosphoribosyl-ATP diphosphatase activity
Atep_24710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Atep_24720	COG0131	Imidazoleglycerol-phosphate dehydratase
Atep_24740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Atep_24750	COG0312	modulator of DNA gyrase
Atep_24760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Atep_24770	COG3164	Protein of unknown function
Atep_24790	COG0424	maF-like protein
Atep_24800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Atep_24810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Atep_24840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_24850	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Atep_24850	COG0392	lysyltransferase activity
Atep_24890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Atep_24900	COG2951	lytic endotransglycosylase activity
Atep_24920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Atep_24940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Atep_24960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Atep_24970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Atep_24980	COG1850	ribulose-bisphosphate carboxylase activity
Atep_24990	COG0432	Pfam Uncharacterised protein family UPF0047
Atep_25090	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Atep_25140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Atep_25150	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Atep_25160	COG1063	alcohol dehydrogenase
Atep_25170	COG0500	methyltransferase
Atep_25180	COG0142	geranyltranstransferase activity
Atep_25220	COG1562	ergosterol biosynthetic process
Atep_25230	COG1233	COG1233 Phytoene dehydrogenase and related
Atep_25260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Atep_25380	COG0745	RESPONSE REGULATOR receiver
Atep_25400	COG1358	cellular component organization or biogenesis
Atep_25500	COG2310	stress, protein
Atep_25550	COG4636	protein conserved in cyanobacteria
Atep_25560	COG1648	precorrin-2 dehydrogenase activity
Atep_25560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Atep_25570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atep_25580	COG0425	Belongs to the sulfur carrier protein TusA family
Atep_25590	COG2210	Belongs to the sulfur carrier protein TusA family
Atep_25600	COG0028	Belongs to the TPP enzyme family
Atep_25610	COG4251	negative regulation of phosphorylation
Atep_25620	COG0784	Response regulator, receiver
Atep_25630	COG0784	Response regulator, receiver
Atep_25630	COG5002	protein histidine kinase activity
Atep_25640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Atep_25670	COG0297	glycogen (starch) synthase activity
Atep_25710	COG1752	Esterase of the alpha-beta hydrolase superfamily
Atep_25720	COG2814	Major facilitator Superfamily
Atep_25740	COG1032	radical SAM domain protein
Atep_25750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Atep_25780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atep_25840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Atep_25840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Atep_25870	COG0569	domain protein
Atep_25870	COG0189	ligase activity
Atep_25900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Atep_25920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Atep_25930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Atep_25960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Atep_25970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Atep_25980	COG1127	ABC transporter
Atep_26000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Atep_26030	COG1137	ATPase activity
Atep_26080	COG1660	Displays ATPase and GTPase activities
Atep_26100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Atep_26110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Atep_26120	COG0154	amidase activity
Atep_26130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Atep_26150	COG1077	Cell shape determining protein MreB Mrl
Atep_26160	COG1792	Involved in formation and maintenance of cell shape
Atep_26170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Atep_26180	COG0768	penicillin binding
Atep_26190	COG0772	Belongs to the SEDS family
Atep_26200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Atep_26210	COG1686	Belongs to the peptidase S11 family
Atep_26220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Atep_26240	COG0321	lipoyl(octanoyl) transferase activity
Atep_26280	COG2205	protein histidine kinase activity
Atep_26300	COG5001	Diguanylate cyclase
Atep_26300	COG4251	negative regulation of phosphorylation
Atep_26300	COG3706	GGDEF domain
Atep_26300	COG2203	Gaf domain
Atep_26310	COG1999	signal sequence binding
Atep_26320	COG2847	Copper chaperone PCu(A)C
Atep_26370	COG1215	transferase activity, transferring glycosyl groups
Atep_26380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Atep_26390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Atep_26400	COG0742	ribosomal rna small subunit methyltransferase
Atep_26420	COG0612	Peptidase, M16
Atep_26450	COG1690	Belongs to the RtcB family
Atep_26460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Atep_26470	COG0174	glutamine synthetase
Atep_26490	COG3852	Histidine kinase
Atep_26500	COG2204	response regulator
Atep_26540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Atep_26600	COG0500	methyltransferase
Atep_26710	COG0438	transferase activity, transferring glycosyl groups
Atep_26740	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Atep_26770	COG3551	Protein conserved in bacteria
Atep_26810	COG2340	Cysteine-rich secretory protein family
Atep_26820	COG1404	Belongs to the peptidase S8 family
Atep_26840	COG0438	transferase activity, transferring glycosyl groups
Atep_26840	COG1216	Glycosyl transferase, family 2
Atep_26870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atep_26950	COG0848	biopolymer transport protein
Atep_26960	COG0848	biopolymer transport protein
Atep_26970	COG0811	peptide transport
Atep_27000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Atep_27010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Atep_27040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Atep_27050	COG0166	Belongs to the GPI family
Atep_27060	COG0583	DNA-binding transcription factor activity
Atep_27100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Atep_27110	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Atep_27160	COG4451	ribulose bisphosphate carboxylase, small
Atep_27170	COG1850	ribulose-bisphosphate carboxylase activity
Atep_27190	COG0659	secondary active sulfate transmembrane transporter activity
Atep_27220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Atep_27230	COG0297	glycogen (starch) synthase activity
Atep_27240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Atep_27250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Atep_27260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Atep_27270	COG0617	tRNA 3'-terminal CCA addition
Atep_27310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Atep_27320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Atep_27340	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Atep_27350	COG2003	Belongs to the UPF0758 family
Atep_27360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Atep_27370	COG0756	dUTP diphosphatase activity
Atep_27390	COG0752	glycyl-tRNA synthetase alpha subunit
Atep_27400	COG0751	glycine-tRNA ligase activity
Atep_27440	COG0187	DNA topoisomerase II activity
Atep_27500	COG2814	Major facilitator Superfamily
Atep_27510	COG0629	single-stranded DNA binding
Atep_27530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Atep_27540	COG1376	ErfK ybiS ycfS ynhG family protein
Atep_27600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Atep_27620	COG2226	methyltransferase
Atep_27640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Atep_27650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Atep_27670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Atep_27680	COG1758	RNA polymerase activity
Atep_27690	COG0194	GDP metabolic process
Atep_27700	COG1561	YicC-like family, N-terminal region
Atep_27710	COG3266	domain, Protein
Atep_27710	COG0515	serine threonine protein kinase
Atep_27720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Atep_27800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Atep_27810	COG4467	Involved in initiation control of chromosome replication
Atep_27830	COG0420	3'-5' exonuclease activity
Atep_27840	COG3328	transposase activity
Atep_27850	COG3328	transposase activity
Atep_27880	COG2161	toxin-antitoxin pair type II binding
Atep_27890	COG4115	mRNA cleavage
Atep_27910	COG1546	Belongs to the CinA family
Atep_27910	COG1058	Belongs to the CinA family
Atep_27970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Atep_27980	COG4999	Histidine kinase
Atep_27980	COG2205	protein histidine kinase activity
Atep_27980	COG3437	response regulator, receiver
Atep_27980	COG3850	Histidine kinase
Atep_27990	COG0167	dihydroorotate dehydrogenase activity
Atep_28000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Atep_28000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Atep_28000	COG1013	pyruvate-flavodoxin oxidoreductase activity
Atep_28000	COG0674	pyruvate-flavodoxin oxidoreductase activity
Atep_28010	COG0456	acetyltransferase
Atep_28030	COG0546	phosphoglycolate phosphatase activity
Atep_28050	COG0667	Aldo Keto reductase
Atep_28110	COG0745	RESPONSE REGULATOR receiver
Atep_28120	COG2205	protein histidine kinase activity
Atep_28130	COG1752	Esterase of the alpha-beta hydrolase superfamily
Atep_28140	COG3876	Protein conserved in bacteria
Atep_28150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Atep_28170	COG0724	RNA recognition motif
Atep_28190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Atep_28190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Atep_28200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Atep_28230	COG1320	monovalent cation:proton antiporter activity
Atep_28240	COG2212	antiporter activity
Atep_28250	COG1863	multisubunit Na H antiporter MnhE subunit
Atep_28260	COG0651	ATP synthesis coupled electron transport
Atep_28270	COG1006	Multisubunit Na H antiporter MnhC subunit
Atep_28280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atep_28280	COG2111	Na H antiporter
Atep_28300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Atep_28310	COG1918	ferrous iron import across plasma membrane
Atep_28380	COG3118	belongs to the thioredoxin family
Atep_28390	COG0375	protein maturation
Atep_28400	COG3909	cytochrome
Atep_28420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Atep_28430	COG0720	synthase
Atep_28440	COG0602	queuosine metabolic process
Atep_28500	COG0457	Tetratricopeptide repeat
Atep_28510	COG0552	protein localization to endoplasmic reticulum
Atep_28520	COG2884	Cell division ATP-binding protein ftsE
Atep_28530	COG2177	Part of the ABC transporter FtsEX involved in
Atep_28550	COG1872	DUF167
Atep_28590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Atep_28600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Atep_28610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Atep_28620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Atep_28630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Atep_28670	COG0006	proline dipeptidase activity
Atep_28680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Atep_28690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Atep_28700	COG0205	6-phosphofructokinase activity
Atep_28710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Atep_28720	COG0315	cyclic pyranopterin monophosphate synthase activity
Atep_28730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Atep_28740	COG4191	Histidine kinase
Atep_28750	COG0297	glycogen (starch) synthase activity
Atep_28760	COG1216	Glycosyl transferase, family 2
Atep_28790	COG0835	chemotaxis
Atep_28800	COG1360	Flagellar Motor Protein
Atep_28810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Atep_28820	COG2201	protein-glutamate methylesterase activity
Atep_28830	COG2198	Histidine kinase
Atep_28830	COG0643	Histidine kinase
Atep_28830	COG0784	Response regulator, receiver
Atep_28840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Atep_29040	COG1677	Flagellar hook-basal body complex protein FliE
Atep_29110	COG0028	Belongs to the TPP enzyme family
Atep_29130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Atep_29160	COG0824	Thioesterase
Atep_29250	COG0271	Belongs to the BolA IbaG family
Atep_29280	COG1414	Transcriptional regulator
Atep_29310	COG1131	(ABC) transporter
Atep_29360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Atep_29430	COG4555	ABC transporter
Atep_29450	COG0604	alcohol dehydrogenase
Atep_29470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Atep_29480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Atep_29490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Atep_29510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Atep_29530	COG0776	regulation of translation
Atep_29590	COG1518	maintenance of DNA repeat elements
Atep_29740	COG1196	nuclear chromosome segregation
Atep_29770	COG4467	Involved in initiation control of chromosome replication
Atep_29780	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Atep_29860	COG4467	Involved in initiation control of chromosome replication
Atep_29890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Atep_29900	COG0706	membrane insertase activity
Atep_29920	COG0594	ribonuclease P activity
Atep_29930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Atep_30140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Atep_30200	COG0616	signal peptide processing
Atep_30200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Atep_30210	COG2916	Histone family protein nucleoid-structuring protein H-NS
Atep_30230	COG3550	peptidyl-serine autophosphorylation
Atep_30310	COG1397	ADP-ribosylglycohydrolase
Atep_30340	COG4467	Involved in initiation control of chromosome replication
Atep_30380	COG1192	Involved in chromosome partitioning
Atep_30440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Atep_30440	COG0758	DNA mediated transformation
Atep_30700	COG1518	maintenance of DNA repeat elements
Atep_30740	COG2304	oxidoreductase activity
Atep_30800	COG4467	Involved in initiation control of chromosome replication
Atep_30840	COG1475	DNA binding
Atep_31140	COG0681	Belongs to the peptidase S26 family
Atep_31340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atep_31370	COG0739	heme binding
Atep_31370	COG0741	lytic transglycosylase activity
Atep_31370	COG1196	nuclear chromosome segregation
Atep_31400	COG0210	DNA helicase
Atep_31420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Atep_31560	COG1203	CRISPR-associated helicase, Cas3