locus-tag	class	description
Alvin_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Alvin_0002	COG0592	DNA-directed DNA polymerase activity
Alvin_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Alvin_0008	COG1136	(ABC) transporter
Alvin_0009	COG0071	Belongs to the small heat shock protein (HSP20) family
Alvin_0011	COG0745	RESPONSE REGULATOR receiver
Alvin_0012	COG2205	protein histidine kinase activity
Alvin_0025	COG0745	RESPONSE REGULATOR receiver
Alvin_0027	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Alvin_0031	COG0187	DNA topoisomerase II activity
Alvin_0033	COG0069	glutamate synthase activity
Alvin_0033	COG0067	glutamate synthase
Alvin_0033	COG0070	glutamate synthase
Alvin_0036	COG0357	Ribosomal RNA small subunit methyltransferase G
Alvin_0037	COG1192	Involved in chromosome partitioning
Alvin_0038	COG1475	DNA binding
Alvin_0039	COG3312	ion transport
Alvin_0040	COG0356	it plays a direct role in the translocation of protons across the membrane
Alvin_0042	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Alvin_0043	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Alvin_0044	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Alvin_0046	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Alvin_0047	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Alvin_0048	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Alvin_0049	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Alvin_0056	COG1490	D-aminoacyl-tRNA deacylase activity
Alvin_0057	COG0596	Alpha beta hydrolase
Alvin_0058	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Alvin_0061	COG3243	poly(R)-hydroxyalkanoic acid synthase
Alvin_0063	COG0183	Belongs to the thiolase family
Alvin_0064	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Alvin_0066	COG1028	Short-chain dehydrogenase reductase Sdr
Alvin_0067	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Alvin_0068	COG0723	plastoquinol--plastocyanin reductase activity
Alvin_0069	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Alvin_0070	COG2857	Cytochrome c1
Alvin_0071	COG0625	glutathione transferase activity
Alvin_0072	COG2969	positive regulation of protein catabolic process
Alvin_0081	COG1238	metal cluster binding
Alvin_0082	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Alvin_0085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Alvin_0087	COG3012	SEC-C Motif Domain Protein
Alvin_0091	COG3258	Cytochrome c
Alvin_0098	COG2186	Transcriptional regulator
Alvin_0103	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Alvin_0104	COG0352	thiamine-phosphate diphosphorylase activity
Alvin_0105	COG0351	phosphomethylpyrimidine kinase
Alvin_0106	COG1773	rubredoxin
Alvin_0109	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Alvin_0110	COG0316	Belongs to the HesB IscA family
Alvin_0112	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Alvin_0118	COG0494	nUDIX hydrolase
Alvin_0119	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Alvin_0120	COG0277	FAD linked oxidase domain protein
Alvin_0121	COG2823	Periplasmic or secreted lipoprotein
Alvin_0122	COG0792	nuclease activity
Alvin_0124	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Alvin_0125	COG2001	Belongs to the MraZ family
Alvin_0126	COG0275	rRNA processing
Alvin_0127	COG3116	cell division
Alvin_0129	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Alvin_0130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Alvin_0131	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Alvin_0132	COG0772	Belongs to the SEDS family
Alvin_0133	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Alvin_0135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Alvin_0136	COG1181	Belongs to the D-alanine--D-alanine ligase family
Alvin_0137	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Alvin_0140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Alvin_0142	COG4942	peptidase
Alvin_0143	COG0653	protein targeting
Alvin_0144	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Alvin_0145	COG0494	nUDIX hydrolase
Alvin_0150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Alvin_0151	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Alvin_0153	COG0217	transcriptional regulatory protein
Alvin_0154	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Alvin_0155	COG0632	four-way junction helicase activity
Alvin_0156	COG3706	GGDEF domain
Alvin_0157	COG0277	FAD linked oxidase domain protein
Alvin_0158	COG0247	lactate metabolic process
Alvin_0160	COG0237	dephospho-CoA kinase activity
Alvin_0163	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Alvin_0165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Alvin_0169	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Alvin_0170	COG0134	indole-3-glycerol-phosphate synthase activity
Alvin_0171	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Alvin_0172	COG1765	OsmC-like protein
Alvin_0173	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Alvin_0176	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Alvin_0177	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Alvin_0178	COG1002	Type II restriction enzyme, methylase subunits
Alvin_0179	COG1061	Type III restriction enzyme res subunit
Alvin_0180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Alvin_0183	COG0840	transmembrane signaling receptor activity
Alvin_0183	COG0840	transmembrane signaling receptor activity
Alvin_0184	COG0737	Belongs to the 5'-nucleotidase family
Alvin_0185	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Alvin_0186	COG0511	ligase activity, forming carbon-carbon bonds
Alvin_0186	COG5016	pyruvate
Alvin_0188	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Alvin_0189	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Alvin_0190	COG2363	Small membrane protein
Alvin_0191	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Alvin_0193	COG0840	transmembrane signaling receptor activity
Alvin_0197	COG0189	ligase activity
Alvin_0199	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Alvin_0200	COG1678	Uncharacterized ACR, COG1678
Alvin_0201	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Alvin_0203	COG0540	Belongs to the ATCase OTCase family
Alvin_0213	COG1216	Glycosyl transferase, family 2
Alvin_0213	COG0438	transferase activity, transferring glycosyl groups
Alvin_0214	COG1216	Glycosyl transferase, family 2
Alvin_0224	COG0438	transferase activity, transferring glycosyl groups
Alvin_0228	COG3293	Transposase
Alvin_0234	COG0745	RESPONSE REGULATOR receiver
Alvin_0235	COG5002	protein histidine kinase activity
Alvin_0237	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_0239	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Alvin_0241	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Alvin_0244	COG1301	dicarboxylic acid transport
Alvin_0247	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Alvin_0249	COG2336	PFAM SpoVT AbrB
Alvin_0250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Alvin_0250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Alvin_0251	COG3100	YcgL domain-containing protein
Alvin_0251	COG0561	phosphatase activity
Alvin_0252	COG0438	transferase activity, transferring glycosyl groups
Alvin_0254	COG1546	Belongs to the CinA family
Alvin_0254	COG1058	Belongs to the CinA family
Alvin_0259	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Alvin_0262	COG1793	dna ligase
Alvin_0263	COG0167	dihydroorotate dehydrogenase activity
Alvin_0264	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Alvin_0264	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Alvin_0264	COG0674	pyruvate-flavodoxin oxidoreductase activity
Alvin_0264	COG1013	pyruvate-flavodoxin oxidoreductase activity
Alvin_0265	COG0456	acetyltransferase
Alvin_0270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Alvin_0271	COG0546	phosphoglycolate phosphatase activity
Alvin_0273	COG0667	Aldo Keto reductase
Alvin_0277	COG0745	RESPONSE REGULATOR receiver
Alvin_0278	COG2205	protein histidine kinase activity
Alvin_0279	COG1752	Esterase of the alpha-beta hydrolase superfamily
Alvin_0280	COG3876	Protein conserved in bacteria
Alvin_0281	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Alvin_0283	COG0724	RNA recognition motif
Alvin_0285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Alvin_0285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Alvin_0286	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Alvin_0287	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Alvin_0287	COG0515	serine threonine protein kinase
Alvin_0292	COG0508	dehydrogenase complex catalyzes the overall conversion of
Alvin_0293	COG0567	Dehydrogenase, E1 component
Alvin_0299	COG0633	Ferredoxin
Alvin_0303	COG0724	RNA recognition motif
Alvin_0304	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Alvin_0305	COG0339	signal peptide processing
Alvin_0308	COG3706	GGDEF domain
Alvin_0311	COG4251	negative regulation of phosphorylation
Alvin_0312	COG0191	fructose-bisphosphate aldolase activity
Alvin_0313	COG0469	pyruvate kinase activity
Alvin_0314	COG0126	phosphoglycerate kinase activity
Alvin_0315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Alvin_0316	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Alvin_0318	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Alvin_0319	COG2226	methyltransferase
Alvin_0320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Alvin_0321	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Alvin_0325	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Alvin_0327	COG1477	protein flavinylation
Alvin_0330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_0331	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_0335	COG4115	mRNA cleavage
Alvin_0336	COG2161	toxin-antitoxin pair type II binding
Alvin_0337	COG0650	Formate hydrogenlyase subunit 4
Alvin_0340	COG2226	methyltransferase
Alvin_0340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Alvin_0340	COG0596	Alpha beta hydrolase
Alvin_0341	COG2995	paraquat-inducible protein a
Alvin_0342	COG3008	intermembrane lipid transfer
Alvin_0344	COG0004	ammonium transporteR
Alvin_0352	COG0840	transmembrane signaling receptor activity
Alvin_0356	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Alvin_0357	COG1573	uracil-dna glycosylase
Alvin_0360	COG0556	nucleotide-excision repair
Alvin_0362	COG0840	transmembrane signaling receptor activity
Alvin_0365	COG2983	Belongs to the UPF0260 family
Alvin_0367	COG4974	Belongs to the 'phage' integrase family
Alvin_0368	COG1666	GTP binding
Alvin_0369	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Alvin_0370	COG0631	protein serine/threonine phosphatase activity
Alvin_0371	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Alvin_0376	COG0438	transferase activity, transferring glycosyl groups
Alvin_0379	COG0573	inorganic phosphate transmembrane transporter activity
Alvin_0381	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Alvin_0382	COG0704	Plays a role in the regulation of phosphate uptake
Alvin_0384	COG0741	lytic transglycosylase activity
Alvin_0384	COG1388	LysM domain
Alvin_0386	COG0328	RNA-DNA hybrid ribonuclease activity
Alvin_0387	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Alvin_0388	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Alvin_0389	COG0504	CTP synthase activity
Alvin_0390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Alvin_0391	COG0148	phosphopyruvate hydratase activity
Alvin_0392	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Alvin_0393	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Alvin_0394	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Alvin_0395	COG0585	pseudouridine synthase activity
Alvin_0405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Alvin_0409	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Alvin_0410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Alvin_0411	COG2171	N-acyltransferase activity
Alvin_0412	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Alvin_0413	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Alvin_0414	COG2894	cell division
Alvin_0415	COG0850	regulation of cytokinetic process
Alvin_0416	COG0537	adenosine 5'-monophosphoramidase activity
Alvin_0417	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Alvin_0418	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Alvin_0419	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Alvin_0424	COG0784	Response regulator, receiver
Alvin_0424	COG5002	protein histidine kinase activity
Alvin_0424	COG2205	protein histidine kinase activity
Alvin_0425	COG3300	MHYT domain
Alvin_0425	COG5001	Diguanylate cyclase
Alvin_0426	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Alvin_0427	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Alvin_0430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Alvin_0433	COG3550	peptidyl-serine autophosphorylation
Alvin_0435	COG4251	negative regulation of phosphorylation
Alvin_0436	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Alvin_0437	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Alvin_0438	COG0215	cysteine-tRNA ligase activity
Alvin_0444	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Alvin_0445	COG4636	protein conserved in cyanobacteria
Alvin_0457	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Alvin_0460	COG0363	glucosamine-6-phosphate deaminase activity
Alvin_0462	COG4067	protein conserved in archaea
Alvin_0462	COG0189	ligase activity
Alvin_0463	COG2308	Evidence 4 Homologs of previously reported genes of
Alvin_0466	COG1295	ribonuclease BN
Alvin_0474	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Alvin_0475	COG2379	hydroxypyruvate reductase
Alvin_0477	COG1214	PFAM Peptidase M22, glycoprotease
Alvin_0479	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Alvin_0481	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Alvin_0482	COG4988	ABC transporter
Alvin_0483	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Alvin_0486	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Alvin_0488	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Alvin_0490	COG1472	Belongs to the glycosyl hydrolase 3 family
Alvin_0491	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Alvin_0493	COG5007	Belongs to the BolA IbaG family
Alvin_0494	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Alvin_0495	COG0165	Argininosuccinate lyase
Alvin_0496	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Alvin_0501	COG0195	Participates in both transcription termination and antitermination
Alvin_0502	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Alvin_0503	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Alvin_0504	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Alvin_0505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Alvin_0506	COG1185	polyribonucleotide nucleotidyltransferase activity
Alvin_0507	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Alvin_0508	COG2308	Evidence 4 Homologs of previously reported genes of
Alvin_0510	COG0864	Transcriptional regulator
Alvin_0516	COG0310	cobalt ion transport
Alvin_0520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Alvin_0521	COG2027	D-alanyl-D-alanine carboxypeptidase
Alvin_0523	COG2226	methyltransferase
Alvin_0525	COG0156	8-amino-7-oxononanoate synthase activity
Alvin_0526	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Alvin_0527	COG1040	competence protein
Alvin_0538	COG3293	Transposase
Alvin_0544	COG2308	Evidence 4 Homologs of previously reported genes of
Alvin_0544	COG2307	Protein conserved in bacteria
Alvin_0546	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Alvin_0548	COG0688	phosphatidylethanolamine metabolic process
Alvin_0550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Alvin_0552	COG1121	(ABC) transporter
Alvin_0553	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Alvin_0561	COG0514	ATP-dependent DNA helicase (RecQ)
Alvin_0562	COG3954	Phosphoribulokinase
Alvin_0564	COG4660	Part of a membrane complex involved in electron transport
Alvin_0565	COG4659	FMN binding
Alvin_0567	COG0659	secondary active sulfate transmembrane transporter activity
Alvin_0569	COG2878	Part of a membrane complex involved in electron transport
Alvin_0570	COG4657	Part of a membrane complex involved in electron transport
Alvin_0572	COG0798	PFAM Bile acid sodium symporter
Alvin_0574	COG0659	secondary active sulfate transmembrane transporter activity
Alvin_0576	COG3263	regulation of cellular component size
Alvin_0577	COG1028	Short-chain dehydrogenase reductase Sdr
Alvin_0579	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Alvin_0583	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Alvin_0584	COG2026	Addiction module toxin, RelE StbE family
Alvin_0585	COG2161	toxin-antitoxin pair type II binding
Alvin_0587	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_0590	COG3706	GGDEF domain
Alvin_0591	COG0745	RESPONSE REGULATOR receiver
Alvin_0593	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Alvin_0595	COG0840	transmembrane signaling receptor activity
Alvin_0599	COG2373	Large extracellular alpha-helical protein
Alvin_0600	COG4953	penicillin-binding protein 1C
Alvin_0601	COG4771	TonB-dependent receptor
Alvin_0603	COG3706	GGDEF domain
Alvin_0604	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Alvin_0607	COG1011	Hydrolase
Alvin_0609	COG0857	belongs to the CobB CobQ family
Alvin_0609	COG0280	phosphate acetyltransferase
Alvin_0610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Alvin_0612	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Alvin_0615	COG2723	6-phospho-beta-galactosidase activity
Alvin_0616	COG4178	(ABC) transporter
Alvin_0618	COG3459	Glycosyltransferase 36 associated
Alvin_0621	COG0768	penicillin binding
Alvin_0623	COG1575	Belongs to the MenA family. Type 1 subfamily
Alvin_0625	COG4456	Virulence-associated protein
Alvin_0626	COG1487	ribonuclease activity
Alvin_0627	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Alvin_0628	COG1169	isochorismate synthase
Alvin_0629	COG0596	Alpha beta hydrolase
Alvin_0629	COG0508	dehydrogenase complex catalyzes the overall conversion of
Alvin_0632	COG0488	(ABC) transporter
Alvin_0635	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Alvin_0636	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Alvin_0637	COG0795	lipopolysaccharide-transporting ATPase activity
Alvin_0639	COG4191	Histidine kinase
Alvin_0640	COG4566	intracellular signal transduction
Alvin_0646	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Alvin_0647	COG1518	maintenance of DNA repeat elements
Alvin_0651	COG1857	crispr-associated protein
Alvin_0656	COG1203	CRISPR-associated helicase, Cas3
Alvin_0663	COG0835	chemotaxis
Alvin_0663	COG0784	Response regulator, receiver
Alvin_0664	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Alvin_0665	COG1815	bacterial-type flagellum-dependent cell motility
Alvin_0666	COG1558	bacterial-type flagellum-dependent cell motility
Alvin_0667	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Alvin_0668	COG1749	Flagellar hook protein flgE
Alvin_0670	COG4786	Flagellar basal body rod
Alvin_0672	COG1706	bacterial-type flagellum-dependent cell motility
Alvin_0673	COG1705	Flagellar rod assembly protein muramidase FlgJ
Alvin_0673	COG3951	Flagellar rod assembly protein muramidase FlgJ
Alvin_0674	COG1256	bacterial-type flagellum assembly
Alvin_0675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Alvin_0677	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Alvin_0687	COG4771	TonB-dependent receptor
Alvin_0689	COG2146	nitrite reductase [NAD(P)H] activity
Alvin_0690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Alvin_0693	COG0825	malonyl-CoA metabolic process
Alvin_0694	COG0037	tRNA processing
Alvin_0696	COG3118	belongs to the thioredoxin family
Alvin_0697	COG3118	belongs to the thioredoxin family
Alvin_0698	COG4566	intracellular signal transduction
Alvin_0699	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Alvin_0699	COG2205	protein histidine kinase activity
Alvin_0700	COG4251	negative regulation of phosphorylation
Alvin_0701	COG4251	negative regulation of phosphorylation
Alvin_0702	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Alvin_0711	COG0505	Belongs to the CarA family
Alvin_0712	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Alvin_0713	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Alvin_0714	COG0455	bacterial-type flagellum organization
Alvin_0716	COG1192	Involved in chromosome partitioning
Alvin_0717	COG0300	oxidoreductase activity
Alvin_0720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Alvin_0721	COG0494	nUDIX hydrolase
Alvin_0722	COG1132	(ABC) transporter
Alvin_0725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Alvin_0726	COG1530	ribonuclease E activity
Alvin_0728	COG0546	phosphoglycolate phosphatase activity
Alvin_0729	COG0616	signal peptide processing
Alvin_0734	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Alvin_0735	COG4106	trans-aconitate 2-methyltransferase activity
Alvin_0736	COG0500	methyltransferase
Alvin_0739	COG0719	Fe-S assembly protein
Alvin_0740	COG0396	ATPase activity
Alvin_0741	COG0719	Fe-S assembly protein
Alvin_0742	COG2151	metal-sulfur cluster biosynthetic enzyme
Alvin_0750	COG4566	intracellular signal transduction
Alvin_0756	COG3885	ferrous iron binding
Alvin_0756	COG2078	PFAM AMMECR1 domain protein
Alvin_0757	COG1355	regulation of microtubule-based process
Alvin_0759	COG0741	lytic transglycosylase activity
Alvin_0759	COG0739	heme binding
Alvin_0759	COG1196	nuclear chromosome segregation
Alvin_0761	COG0730	response to heat
Alvin_0763	COG2226	methyltransferase
Alvin_0764	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Alvin_0765	COG0596	Alpha beta hydrolase
Alvin_0766	COG1469	GTP cyclohydrolase I activity
Alvin_0767	COG0142	geranyltranstransferase activity
Alvin_0768	COG1722	exodeoxyribonuclease VII activity
Alvin_0769	COG0187	DNA topoisomerase II activity
Alvin_0773	COG0268	Binds directly to 16S ribosomal RNA
Alvin_0774	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Alvin_0777	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Alvin_0778	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Alvin_0779	COG1388	LysM domain
Alvin_0779	COG4942	peptidase
Alvin_0781	COG3278	Belongs to the heme-copper respiratory oxidase family
Alvin_0785	COG0348	domain, Protein
Alvin_0787	COG2217	Heavy metal translocating P-type atpase
Alvin_0789	COG0840	transmembrane signaling receptor activity
Alvin_0792	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Alvin_0792	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Alvin_0797	COG3830	Belongs to the UPF0237 family
Alvin_0798	COG0242	peptide deformylase activity
Alvin_0799	COG0793	Belongs to the peptidase S41A family
Alvin_0800	COG2918	glutathione biosynthetic process
Alvin_0801	COG0248	Ppx GppA phosphatase
Alvin_0803	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Alvin_0804	COG0508	dehydrogenase complex catalyzes the overall conversion of
Alvin_0811	COG0343	queuine tRNA-ribosyltransferase activity
Alvin_0812	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Alvin_0813	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Alvin_0814	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Alvin_0815	COG3178	'Phosphotransferase
Alvin_0820	COG0151	Belongs to the GarS family
Alvin_0821	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Alvin_0822	COG0138	bifunctional purine biosynthesis protein purh
Alvin_0823	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Alvin_0824	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Alvin_0830	COG3344	reverse transcriptase
Alvin_0833	COG2264	protein methyltransferase activity
Alvin_0834	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Alvin_0835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Alvin_0836	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Alvin_0838	COG0628	permease
Alvin_0843	COG0668	transmembrane transport
Alvin_0845	COG4591	ABC-type transport system involved in lipoprotein release permease component
Alvin_0848	COG0658	competence protein
Alvin_0848	COG2333	competence protein COMEC
Alvin_0849	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Alvin_0850	COG0406	alpha-ribazole phosphatase activity
Alvin_0851	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Alvin_0852	COG4206	TonB-dependent receptor
Alvin_0854	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Alvin_0856	COG3028	Belongs to the UPF0307 family
Alvin_0858	COG2304	oxidoreductase activity
Alvin_0860	COG1902	pentaerythritol trinitrate reductase activity
Alvin_0864	COG1959	2 iron, 2 sulfur cluster binding
Alvin_0865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Alvin_0867	COG1560	Kdo2-lipid A biosynthetic process
Alvin_0872	COG4149	molybdate abc transporter
Alvin_0874	COG4774	siderophore transport
Alvin_0877	COG0848	biopolymer transport protein
Alvin_0878	COG0811	peptide transport
Alvin_0880	COG4772	TonB-dependent receptor
Alvin_0883	COG2199	diguanylate cyclase activity
Alvin_0883	COG2200	EAL domain
Alvin_0883	COG3287	FIST C domain
Alvin_0889	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Alvin_0890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Alvin_0891	COG0582	viral genome integration into host DNA
Alvin_0895	COG4983	Phage plasmid primase, P4 family domain protein
Alvin_0908	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Alvin_0909	COG0501	Belongs to the peptidase M48B family
Alvin_0910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Alvin_0911	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Alvin_0912	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Alvin_0913	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Alvin_0914	COG0509	glycine decarboxylation via glycine cleavage system
Alvin_0915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Alvin_0917	COG0495	leucyl-tRNA aminoacylation
Alvin_0918	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Alvin_0919	COG0483	inositol monophosphate 1-phosphatase activity
Alvin_0921	COG0012	GTP binding
Alvin_0924	COG0668	transmembrane transport
Alvin_0927	COG4109	DRTGG domain
Alvin_0934	COG2201	protein-glutamate methylesterase activity
Alvin_0940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Alvin_0944	COG0745	RESPONSE REGULATOR receiver
Alvin_0945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_0946	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Alvin_0948	COG0028	Belongs to the TPP enzyme family
Alvin_0949	COG0440	acetolactate synthase activity
Alvin_0950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Alvin_0951	COG0824	Thioesterase
Alvin_0955	COG0823	Involved in the tonB-independent uptake of proteins
Alvin_0960	COG0271	Belongs to the BolA IbaG family
Alvin_0963	COG1414	Transcriptional regulator
Alvin_0966	COG1131	(ABC) transporter
Alvin_0969	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Alvin_0971	COG3706	GGDEF domain
Alvin_0972	COG0840	transmembrane signaling receptor activity
Alvin_0973	COG2205	protein histidine kinase activity
Alvin_0973	COG0784	Response regulator, receiver
Alvin_0973	COG5002	protein histidine kinase activity
Alvin_0976	COG4555	ABC transporter
Alvin_0978	COG0604	alcohol dehydrogenase
Alvin_0980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Alvin_0982	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Alvin_0984	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Alvin_0986	COG0776	regulation of translation
Alvin_0988	COG0429	hydrolase of the alpha beta-hydrolase fold
Alvin_0990	COG4682	membrane
Alvin_0992	COG1397	ADP-ribosylglycohydrolase
Alvin_0999	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Alvin_1006	COG0450	alkyl hydroperoxide reductase
Alvin_1012	COG2824	Alkylphosphonate utilization operon protein PhnA
Alvin_1015	COG0811	peptide transport
Alvin_1016	COG0848	biopolymer transport protein
Alvin_1017	COG1132	(ABC) transporter
Alvin_1018	COG1663	tetraacyldisaccharide 4'-kinase activity
Alvin_1021	COG1028	Short-chain dehydrogenase reductase Sdr
Alvin_1022	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Alvin_1023	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Alvin_1024	COG0308	aminopeptidase N
Alvin_1034	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Alvin_1037	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Alvin_1040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Alvin_1042	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Alvin_1050	COG1136	(ABC) transporter
Alvin_1056	COG2205	protein histidine kinase activity
Alvin_1056	COG0784	Response regulator, receiver
Alvin_1056	COG2198	Histidine kinase
Alvin_1057	COG4585	Histidine kinase
Alvin_1058	COG2197	response regulator
Alvin_1061	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Alvin_1062	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Alvin_1063	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Alvin_1064	COG1242	4 iron, 4 sulfur cluster binding
Alvin_1069	COG0840	transmembrane signaling receptor activity
Alvin_1075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Alvin_1079	COG3038	cytochrome b561
Alvin_1082	COG1053	succinate dehydrogenase
Alvin_1088	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Alvin_1089	COG0163	prenyltransferase activity
Alvin_1090	COG1444	tRNA N-acetyltransferase activity
Alvin_1092	COG0446	pyridine nucleotide-disulphide oxidoreductase
Alvin_1093	COG2863	cytochrome
Alvin_1094	COG0666	response to abiotic stimulus
Alvin_1095	COG3005	denitrification pathway
Alvin_1096	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Alvin_1099	COG2137	regulation of response to DNA damage stimulus
Alvin_1100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Alvin_1102	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Alvin_1103	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Alvin_1107	COG0730	response to heat
Alvin_1108	COG1131	(ABC) transporter
Alvin_1109	COG0842	Transport permease protein
Alvin_1110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Alvin_1115	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Alvin_1118	COG2046	Belongs to the sulfate adenylyltransferase family
Alvin_1123	COG1047	Peptidyl-prolyl cis-trans
Alvin_1127	COG0529	Catalyzes the synthesis of activated sulfate
Alvin_1128	COG1199	ATP-dependent helicase activity
Alvin_1132	COG0418	dihydroorotase activity
Alvin_1133	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Alvin_1134	COG1177	transmembrane transport
Alvin_1135	COG1176	ABC-type spermidine putrescine transport system, permease component I
Alvin_1136	COG3842	ATPase activity
Alvin_1137	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Alvin_1138	COG0107	imidazoleglycerol-phosphate synthase activity
Alvin_1140	COG0675	Transposase, IS605 OrfB family
Alvin_1141	COG1272	protein, Hemolysin III
Alvin_1147	COG5001	Diguanylate cyclase
Alvin_1155	COG3459	Glycosyltransferase 36 associated
Alvin_1158	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Alvin_1160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Alvin_1161	COG2205	protein histidine kinase activity
Alvin_1162	COG0745	RESPONSE REGULATOR receiver
Alvin_1166	COG4325	translation initiation factor activity
Alvin_1170	COG5001	Diguanylate cyclase
Alvin_1171	COG2878	Part of a membrane complex involved in electron transport
Alvin_1171	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Alvin_1172	COG0674	pyruvate-flavodoxin oxidoreductase activity
Alvin_1172	COG1013	pyruvate-flavodoxin oxidoreductase activity
Alvin_1172	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Alvin_1172	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Alvin_1173	COG4656	Part of a membrane complex involved in electron transport
Alvin_1174	COG4658	electron transport chain
Alvin_1175	COG4659	FMN binding
Alvin_1176	COG4660	Part of a membrane complex involved in electron transport
Alvin_1177	COG4657	Part of a membrane complex involved in electron transport
Alvin_1179	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Alvin_1180	COG0196	riboflavin kinase activity
Alvin_1181	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Alvin_1183	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Alvin_1192	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Alvin_1193	COG4181	ATPase activity
Alvin_1198	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Alvin_1199	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Alvin_1200	COG1862	Preprotein translocase
Alvin_1201	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Alvin_1201	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Alvin_1204	COG1528	Iron-storage protein
Alvin_1208	COG3706	GGDEF domain
Alvin_1212	COG0617	tRNA 3'-terminal CCA addition
Alvin_1214	COG3437	response regulator, receiver
Alvin_1216	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Alvin_1217	COG0442	prolyl-tRNA aminoacylation
Alvin_1219	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Alvin_1219	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Alvin_1220	COG0802	atpase or kinase
Alvin_1221	COG0860	N-Acetylmuramoyl-L-alanine amidase
Alvin_1222	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Alvin_1223	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Alvin_1224	COG1923	regulation of RNA biosynthetic process
Alvin_1225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Alvin_1226	COG0330	HflC and HflK could
Alvin_1227	COG0330	HflC and HflK could
Alvin_1229	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Alvin_1230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Alvin_1233	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Alvin_1233	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Alvin_1236	COG2076	Multidrug Resistance protein
Alvin_1239	COG0670	Belongs to the BI1 family
Alvin_1240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Alvin_1243	COG1283	sodium-dependent phosphate transmembrane transporter activity
Alvin_1246	COG0306	phosphate transporter
Alvin_1247	COG1392	Phosphate transport regulator
Alvin_1251	COG2221	Nitrite and sulphite reductase 4Fe-4S
Alvin_1252	COG2221	Nitrite and sulphite reductase 4Fe-4S
Alvin_1253	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Alvin_1254	COG2923	Belongs to the DsrF TusC family
Alvin_1256	COG2920	part of a sulfur-relay system
Alvin_1263	COG1797	cobyrinic acid a,c-diamide synthase activity
Alvin_1266	COG2255	four-way junction helicase activity
Alvin_1273	COG1160	GTP binding
Alvin_1276	COG0124	histidyl-tRNA synthetase
Alvin_1278	COG3063	Type IV pilus biogenesis stability protein PilW
Alvin_1279	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Alvin_1280	COG0105	UTP biosynthetic process
Alvin_1283	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Alvin_1285	COG0557	exoribonuclease II activity
Alvin_1286	COG3108	Peptidase M15
Alvin_1296	COG0628	permease
Alvin_1311	COG1902	pentaerythritol trinitrate reductase activity
Alvin_1314	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Alvin_1317	COG0243	molybdopterin cofactor binding
Alvin_1327	COG0729	surface antigen
Alvin_1328	COG2911	Protein conserved in bacteria
Alvin_1329	COG1560	Kdo2-lipid A biosynthetic process
Alvin_1332	COG1196	nuclear chromosome segregation
Alvin_1333	COG3115	cell septum assembly
Alvin_1334	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Alvin_1336	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Alvin_1337	COG2350	Protein conserved in bacteria
Alvin_1338	COG2917	probably involved in intracellular septation
Alvin_1339	COG1115	amino acid carrier protein
Alvin_1341	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Alvin_1343	COG4251	negative regulation of phosphorylation
Alvin_1344	COG1394	ATPase activity, coupled to movement of substances
Alvin_1346	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Alvin_1350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Alvin_1351	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Alvin_1352	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Alvin_1355	COG1269	ATP hydrolysis coupled proton transport
Alvin_1359	COG0542	response to heat
Alvin_1360	COG3267	Type II secretory pathway component ExeA
Alvin_1360	COG3409	Peptidoglycan-binding domain 1 protein
Alvin_1362	COG2239	Acts as a magnesium transporter
Alvin_1373	COG2205	protein histidine kinase activity
Alvin_1373	COG5002	protein histidine kinase activity
Alvin_1373	COG0784	Response regulator, receiver
Alvin_1379	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Alvin_1382	COG0497	DNA recombination
Alvin_1383	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Alvin_1384	COG1420	regulation of RNA biosynthetic process
Alvin_1385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Alvin_1386	COG0443	Heat shock 70 kDa protein
Alvin_1387	COG0484	heat shock protein binding
Alvin_1389	COG0709	Synthesizes selenophosphate from selenide and ATP
Alvin_1390	COG3276	selenocysteine insertion sequence binding
Alvin_1392	COG2354	Protein conserved in bacteria
Alvin_1396	COG2862	Uncharacterized protein family, UPF0114
Alvin_1397	COG5001	Diguanylate cyclase
Alvin_1397	COG4251	negative regulation of phosphorylation
Alvin_1397	COG3706	GGDEF domain
Alvin_1397	COG2203	Gaf domain
Alvin_1399	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Alvin_1403	COG3123	guanosine phosphorylase activity
Alvin_1404	COG0651	ATP synthesis coupled electron transport
Alvin_1405	COG0651	ATP synthesis coupled electron transport
Alvin_1406	COG1007	ATP synthesis coupled electron transport
Alvin_1407	COG0651	ATP synthesis coupled electron transport
Alvin_1409	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Alvin_1409	COG2111	Na H antiporter
Alvin_1414	COG0318	PFAM AMP-dependent synthetase and ligase
Alvin_1415	COG0033	Phosphoglucomutase
Alvin_1416	COG0326	Molecular chaperone. Has ATPase activity
Alvin_1417	COG0563	adenylate kinase activity
Alvin_1418	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Alvin_1420	COG1959	2 iron, 2 sulfur cluster binding
Alvin_1424	COG0740	serine-type endopeptidase activity
Alvin_1425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Alvin_1426	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Alvin_1427	COG0776	regulation of translation
Alvin_1428	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Alvin_1431	COG0601	transmembrane transport
Alvin_1432	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Alvin_1435	COG0783	Belongs to the Dps family
Alvin_1436	COG1278	Cold shock
Alvin_1437	COG1674	ftsk spoiiie
Alvin_1438	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Alvin_1439	COG0446	pyridine nucleotide-disulphide oxidoreductase
Alvin_1440	COG0463	Glycosyl transferase, family 2
Alvin_1446	COG3093	addiction module antidote protein HigA
Alvin_1450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Alvin_1451	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Alvin_1457	COG1131	(ABC) transporter
Alvin_1458	COG0842	Transport permease protein
Alvin_1467	COG1064	alcohol dehydrogenase
Alvin_1469	COG0590	tRNA wobble adenosine to inosine editing
Alvin_1475	COG0443	Heat shock 70 kDa protein
Alvin_1476	COG0297	glycogen (starch) synthase activity
Alvin_1477	COG0366	Alpha amylase catalytic
Alvin_1479	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Alvin_1482	COG3122	Protein conserved in bacteria
Alvin_1483	COG0084	hydrolase, TatD family'
Alvin_1489	COG3850	Histidine kinase
Alvin_1489	COG3437	response regulator, receiver
Alvin_1489	COG2205	protein histidine kinase activity
Alvin_1489	COG4999	Histidine kinase
Alvin_1490	COG2205	protein histidine kinase activity
Alvin_1490	COG5002	protein histidine kinase activity
Alvin_1490	COG0784	Response regulator, receiver
Alvin_1491	COG5002	protein histidine kinase activity
Alvin_1491	COG0784	Response regulator, receiver
Alvin_1491	COG2205	protein histidine kinase activity
Alvin_1493	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Alvin_1494	COG2835	tetraacyldisaccharide 4'-kinase activity
Alvin_1501	COG0318	PFAM AMP-dependent synthetase and ligase
Alvin_1503	COG0058	SHG alpha-glucan phosphorylase activity
Alvin_1505	COG0045	succinate-CoA ligase (ADP-forming) activity
Alvin_1506	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Alvin_1507	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Alvin_1508	COG2920	part of a sulfur-relay system
Alvin_1509	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Alvin_1510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Alvin_1511	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Alvin_1513	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Alvin_1514	COG2915	High frequency lysogenization protein hflD homolog
Alvin_1515	COG0482	sulfurtransferase activity
Alvin_1517	COG0726	polysaccharide deacetylase
Alvin_1518	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Alvin_1518	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Alvin_1519	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Alvin_1520	COG2119	membrane
Alvin_1521	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_1522	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_1523	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Alvin_1525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Alvin_1526	COG1918	ferrous iron import across plasma membrane
Alvin_1530	COG0640	Transcriptional regulator
Alvin_1531	COG0701	Predicted permease
Alvin_1537	COG0463	Glycosyl transferase, family 2
Alvin_1546	COG0322	excinuclease ABC activity
Alvin_1547	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Alvin_1548	COG0500	methyltransferase
Alvin_1550	COG0616	signal peptide processing
Alvin_1551	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Alvin_1552	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Alvin_1553	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Alvin_1553	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Alvin_1554	COG3264	Mechanosensitive ion channel
Alvin_1554	COG1511	domain protein
Alvin_1555	COG0589	response to stress
Alvin_1559	COG1028	Short-chain dehydrogenase reductase Sdr
Alvin_1562	COG0735	belongs to the Fur family
Alvin_1563	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Alvin_1574	COG2201	protein-glutamate methylesterase activity
Alvin_1575	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Alvin_1576	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Alvin_1577	COG0835	chemotaxis
Alvin_1578	COG0840	transmembrane signaling receptor activity
Alvin_1579	COG0643	Histidine kinase
Alvin_1579	COG2198	Histidine kinase
Alvin_1582	COG0745	RESPONSE REGULATOR receiver
Alvin_1587	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Alvin_1588	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Alvin_1593	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Alvin_1594	COG0557	exoribonuclease II activity
Alvin_1598	COG0285	dihydrofolate synthase activity
Alvin_1599	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Alvin_1600	COG0159	tryptophan synthase activity
Alvin_1601	COG0133	tryptophan synthase activity
Alvin_1602	COG0135	phosphoribosylanthranilate isomerase activity
Alvin_1603	COG0101	tRNA pseudouridine synthase activity
Alvin_1606	COG0473	3-isopropylmalate dehydrogenase activity
Alvin_1607	COG0066	3-isopropylmalate dehydratase activity
Alvin_1608	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Alvin_1616	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Alvin_1618	COG1363	Peptidase, m42
Alvin_1620	COG0367	asparagine synthase
Alvin_1624	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Alvin_1628	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Alvin_1629	COG0424	maF-like protein
Alvin_1632	COG1254	Belongs to the acylphosphatase family
Alvin_1635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Alvin_1636	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Alvin_1637	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Alvin_1642	COG0745	RESPONSE REGULATOR receiver
Alvin_1643	COG5002	protein histidine kinase activity
Alvin_1644	COG0776	regulation of translation
Alvin_1646	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Alvin_1647	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Alvin_1649	COG0717	Belongs to the dCTP deaminase family
Alvin_1650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Alvin_1652	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Alvin_1653	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Alvin_1658	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Alvin_1662	COG1286	toxin biosynthetic process
Alvin_1664	COG1546	Belongs to the CinA family
Alvin_1668	COG0511	ligase activity, forming carbon-carbon bonds
Alvin_1668	COG5016	pyruvate
Alvin_1669	COG0439	Biotin carboxylase
Alvin_1671	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Alvin_1674	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Alvin_1675	COG1120	ATPase activity
Alvin_1683	COG3721	Heme iron utilization protein
Alvin_1690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Alvin_1691	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Alvin_1694	COG4654	Cytochrome c, class I
Alvin_1695	COG0582	viral genome integration into host DNA
Alvin_1702	COG4983	Phage plasmid primase, P4 family domain protein
Alvin_1714	COG1519	Transferase
Alvin_1715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Alvin_1716	COG1381	Involved in DNA repair and RecF pathway recombination
Alvin_1718	COG0571	ribonuclease III activity
Alvin_1720	COG0681	Belongs to the peptidase S26 family
Alvin_1721	COG0481	GTPase activity
Alvin_1722	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Alvin_1728	COG1042	CoA-binding domain protein
Alvin_1728	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Alvin_1728	COG0045	succinate-CoA ligase (ADP-forming) activity
Alvin_1729	COG0123	including yeast histone deacetylase and acetoin utilization protein
Alvin_1730	COG2826	transposase and inactivated derivatives, IS30 family
Alvin_1735	COG2154	pterin-4-alpha-carbinolamine dehydratase
Alvin_1742	COG1342	Belongs to the UPF0251 family
Alvin_1744	COG1160	GTP binding
Alvin_1745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Alvin_1749	COG0704	Plays a role in the regulation of phosphate uptake
Alvin_1750	COG5002	protein histidine kinase activity
Alvin_1752	COG0671	phosphoesterase, PA-phosphatase related
Alvin_1754	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Alvin_1755	COG1509	lysine 2,3-aminomutase activity
Alvin_1757	COG0741	lytic transglycosylase activity
Alvin_1758	COG3267	Type II secretory pathway component ExeA
Alvin_1758	COG3409	Peptidoglycan-binding domain 1 protein
Alvin_1760	COG0489	protein tyrosine kinase activity
Alvin_1765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Alvin_1767	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Alvin_1768	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Alvin_1772	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Alvin_1772	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Alvin_1773	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Alvin_1774	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Alvin_1776	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Alvin_1777	COG0583	DNA-binding transcription factor activity
Alvin_1778	COG0367	asparagine synthase
Alvin_1779	COG0438	transferase activity, transferring glycosyl groups
Alvin_1785	COG0489	protein tyrosine kinase activity
Alvin_1788	COG2204	response regulator
Alvin_1789	COG0784	Response regulator, receiver
Alvin_1789	COG2205	protein histidine kinase activity
Alvin_1793	COG2226	methyltransferase
Alvin_1795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Alvin_1796	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Alvin_1799	COG0463	Glycosyl transferase, family 2
Alvin_1801	COG2244	polysaccharide biosynthetic process
Alvin_1812	COG0367	asparagine synthase
Alvin_1816	COG2217	Heavy metal translocating P-type atpase
Alvin_1817	COG1797	cobyrinic acid a,c-diamide synthase activity
Alvin_1819	COG1253	flavin adenine dinucleotide binding
Alvin_1825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Alvin_1826	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Alvin_1834	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Alvin_1839	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Alvin_1840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Alvin_1843	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Alvin_1844	COG5265	(ABC) transporter
Alvin_1845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Alvin_1846	COG2010	Cytochrome c
Alvin_1847	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Alvin_1847	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Alvin_1848	COG2224	Isocitrate lyase
Alvin_1849	COG0259	pyridoxamine-phosphate oxidase activity
Alvin_1851	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Alvin_1852	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Alvin_1854	COG1022	Amp-dependent synthetase and ligase
Alvin_1855	COG1194	a g-specific adenine glycosylase
Alvin_1856	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Alvin_1857	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Alvin_1859	COG5001	Diguanylate cyclase
Alvin_1859	COG4251	negative regulation of phosphorylation
Alvin_1859	COG2203	Gaf domain
Alvin_1859	COG3706	GGDEF domain
Alvin_1863	COG1183	phosphatidylcholine synthase activity
Alvin_1864	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Alvin_1866	COG3383	formate dehydrogenase (NAD+) activity
Alvin_1867	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Alvin_1868	COG3259	Nickel-dependent hydrogenase
Alvin_1872	COG0840	transmembrane signaling receptor activity
Alvin_1881	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Alvin_1886	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Alvin_1887	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Alvin_1888	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Alvin_1889	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Alvin_1890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Alvin_1893	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Alvin_1894	COG0416	fatty acid biosynthetic process
Alvin_1895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Alvin_1897	COG4566	intracellular signal transduction
Alvin_1901	COG2304	oxidoreductase activity
Alvin_1904	COG0714	Associated with various cellular activities
Alvin_1906	COG0439	Biotin carboxylase
Alvin_1907	COG0511	ligase activity, forming carbon-carbon bonds
Alvin_1908	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Alvin_1909	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Alvin_1910	COG4232	protein-disulfide reductase activity
Alvin_1911	COG1324	tolerance protein
Alvin_1912	COG3030	protein affecting phage T7 exclusion by the F plasmid
Alvin_1917	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Alvin_1919	COG0367	asparagine synthase
Alvin_1920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Alvin_1921	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Alvin_1925	COG0129	dihydroxy-acid dehydratase activity
Alvin_1926	COG0521	Mo-molybdopterin cofactor biosynthetic process
Alvin_1927	COG0303	'Molybdopterin
Alvin_1928	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Alvin_1931	COG0277	FAD linked oxidase domain protein
Alvin_1933	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Alvin_1938	COG0535	radical SAM domain protein
Alvin_1942	COG1028	Short-chain dehydrogenase reductase Sdr
Alvin_1943	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Alvin_1944	COG0275	rRNA processing
Alvin_1956	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Alvin_1957	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Alvin_1961	COG1053	succinate dehydrogenase
Alvin_1963	COG2009	succinate dehydrogenase
Alvin_1966	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Alvin_1967	COG1216	Glycosyl transferase, family 2
Alvin_1971	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Alvin_1972	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Alvin_1973	COG0697	spore germination
Alvin_1976	COG3437	response regulator, receiver
Alvin_1977	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Alvin_1978	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Alvin_1979	COG0189	ligase activity
Alvin_1981	COG0471	metal ion transport
Alvin_1981	COG3273	potassium ion transport
Alvin_1982	COG1643	Atp-dependent helicase
Alvin_1983	COG3706	GGDEF domain
Alvin_1983	COG0745	RESPONSE REGULATOR receiver
Alvin_1986	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Alvin_1988	COG3300	MHYT domain
Alvin_1988	COG5001	Diguanylate cyclase
Alvin_1990	COG0402	S-adenosylhomocysteine deaminase activity
Alvin_1994	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Alvin_1997	COG0359	binds to the 23S rRNA
Alvin_2000	COG0360	Binds together with S18 to 16S ribosomal RNA
Alvin_2004	COG2716	regulation of RNA biosynthetic process
Alvin_2005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Alvin_2007	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Alvin_2013	COG0489	protein tyrosine kinase activity
Alvin_2014	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Alvin_2015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Alvin_2018	COG1643	Atp-dependent helicase
Alvin_2019	COG3338	carbonate dehydratase activity
Alvin_2024	COG1408	metallophosphoesterase
Alvin_2029	COG4245	von Willebrand factor, type A
Alvin_2030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Alvin_2032	COG0386	Belongs to the glutathione peroxidase family
Alvin_2033	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Alvin_2036	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Alvin_2042	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Alvin_2043	COG0024	Methionine aminopeptidase
Alvin_2044	COG0052	Belongs to the universal ribosomal protein uS2 family
Alvin_2045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Alvin_2046	COG0528	UMP kinase activity
Alvin_2047	COG0233	cytoplasmic translational termination
Alvin_2048	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Alvin_2052	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Alvin_2054	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Alvin_2055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Alvin_2056	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Alvin_2058	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Alvin_2059	COG0019	diaminopimelate decarboxylase activity
Alvin_2061	COG1982	Orn Lys Arg decarboxylase major
Alvin_2062	COG0708	Exodeoxyribonuclease III
Alvin_2064	COG1331	Highly conserved protein containing a thioredoxin domain
Alvin_2067	COG0009	L-threonylcarbamoyladenylate synthase
Alvin_2070	COG2922	Belongs to the Smg family
Alvin_2071	COG0758	DNA mediated transformation
Alvin_2073	COG0242	peptide deformylase activity
Alvin_2074	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Alvin_2078	COG2204	response regulator
Alvin_2079	COG0569	domain protein
Alvin_2080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Alvin_2081	COG1763	Mo-molybdopterin cofactor biosynthetic process
Alvin_2082	COG0287	Prephenate dehydrogenase
Alvin_2083	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Alvin_2084	COG0077	Prephenate dehydratase
Alvin_2084	COG1605	Chorismate mutase
Alvin_2085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Alvin_2089	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Alvin_2091	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Alvin_2094	COG2770	Histidine kinase
Alvin_2094	COG2208	phosphoserine phosphatase activity
Alvin_2097	COG1366	Belongs to the anti-sigma-factor antagonist family
Alvin_2098	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Alvin_2103	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Alvin_2104	COG0676	glucose-6-phosphate 1-epimerase activity
Alvin_2105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Alvin_2105	COG0574	Belongs to the PEP-utilizing enzyme family
Alvin_2106	COG0525	valine-tRNA ligase activity
Alvin_2110	COG4783	chaperone-mediated protein folding
Alvin_2113	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Alvin_2114	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Alvin_2115	COG1162	GTPase activity
Alvin_2118	COG1278	Cold shock
Alvin_2119	COG2183	response to ionizing radiation
Alvin_2122	COG1968	undecaprenyl-diphosphatase activity
Alvin_2124	COG0436	Aminotransferase
Alvin_2126	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Alvin_2128	COG0297	glycogen (starch) synthase activity
Alvin_2132	COG2814	Major facilitator Superfamily
Alvin_2133	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Alvin_2134	COG1538	Outer membrane efflux protein
Alvin_2140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Alvin_2142	COG0438	transferase activity, transferring glycosyl groups
Alvin_2144	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Alvin_2145	COG0446	pyridine nucleotide-disulphide oxidoreductase
Alvin_2147	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Alvin_2150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Alvin_2151	COG2967	ApaG domain
Alvin_2154	COG0429	hydrolase of the alpha beta-hydrolase fold
Alvin_2156	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Alvin_2158	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Alvin_2159	COG0142	geranyltranstransferase activity
Alvin_2163	COG3162	membrane
Alvin_2164	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Alvin_2165	COG2203	Gaf domain
Alvin_2165	COG5001	Diguanylate cyclase
Alvin_2165	COG4251	negative regulation of phosphorylation
Alvin_2165	COG3706	GGDEF domain
Alvin_2166	COG2205	protein histidine kinase activity
Alvin_2166	COG0784	Response regulator, receiver
Alvin_2166	COG5002	protein histidine kinase activity
Alvin_2167	COG0737	Belongs to the 5'-nucleotidase family
Alvin_2172	COG1403	HNH endonuclease
Alvin_2173	COG0116	Belongs to the methyltransferase superfamily
Alvin_2173	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Alvin_2174	COG4133	protoheme IX ABC transporter activity
Alvin_2176	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Alvin_2178	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Alvin_2180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Alvin_2181	COG3088	subunit of a heme lyase
Alvin_2181	COG4235	cytochrome complex assembly
Alvin_2183	COG1881	PFAM PEBP family protein
Alvin_2184	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Alvin_2186	COG3409	Peptidoglycan-binding domain 1 protein
Alvin_2186	COG3773	Cell wall hydrolase
Alvin_2187	COG0586	Pfam SNARE associated Golgi protein
Alvin_2188	COG0733	neurotransmitter:sodium symporter activity
Alvin_2189	COG1686	Belongs to the peptidase S11 family
Alvin_2190	COG1187	pseudouridine synthase activity
Alvin_2191	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Alvin_2193	COG0180	Tryptophanyl-tRNA synthetase
Alvin_2194	COG1994	Peptidase M50
Alvin_2195	COG0009	L-threonylcarbamoyladenylate synthase
Alvin_2196	COG0613	PHP domain protein
Alvin_2204	COG3045	CreA protein
Alvin_2208	COG2718	Belongs to the UPF0229 family
Alvin_2209	COG2766	serine protein kinase
Alvin_2211	COG0840	transmembrane signaling receptor activity
Alvin_2212	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Alvin_2213	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Alvin_2215	COG2974	May be involved in recombination
Alvin_2216	COG4536	flavin adenine dinucleotide binding
Alvin_2217	COG2211	Major facilitator Superfamily
Alvin_2219	COG1278	Cold shock
Alvin_2220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Alvin_2221	COG0542	response to heat
Alvin_2222	COG0840	transmembrane signaling receptor activity
Alvin_2223	COG1492	cobalamin metabolic process
Alvin_2225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Alvin_2227	COG0084	hydrolase, TatD family'
Alvin_2230	COG0840	transmembrane signaling receptor activity
Alvin_2233	COG2201	protein-glutamate methylesterase activity
Alvin_2235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Alvin_2237	COG0835	chemotaxis
Alvin_2238	COG0643	Histidine kinase
Alvin_2238	COG2198	Histidine kinase
Alvin_2239	COG0745	RESPONSE REGULATOR receiver
Alvin_2240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Alvin_2243	COG0735	belongs to the Fur family
Alvin_2248	COG4771	TonB-dependent receptor
Alvin_2249	COG0811	peptide transport
Alvin_2250	COG0848	biopolymer transport protein
Alvin_2255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Alvin_2255	COG1918	ferrous iron import across plasma membrane
Alvin_2256	COG1918	ferrous iron import across plasma membrane
Alvin_2256	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Alvin_2258	COG3706	GGDEF domain
Alvin_2261	COG0583	DNA-binding transcription factor activity
Alvin_2262	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Alvin_2263	COG0735	belongs to the Fur family
Alvin_2266	COG0577	efflux transmembrane transporter activity
Alvin_2266	COG1136	(ABC) transporter
Alvin_2267	COG0803	Belongs to the bacterial solute-binding protein 9 family
Alvin_2267	COG3443	Belongs to the bacterial solute-binding protein 9 family
Alvin_2269	COG2867	negative regulation of translational initiation
Alvin_2270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Alvin_2271	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Alvin_2272	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Alvin_2275	COG0791	NLP P60 protein
Alvin_2276	COG0492	ferredoxin-NADP+ reductase activity
Alvin_2277	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Alvin_2278	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Alvin_2280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Alvin_2281	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Alvin_2283	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Alvin_2284	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Alvin_2285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Alvin_2286	COG0745	RESPONSE REGULATOR receiver
Alvin_2286	COG3706	GGDEF domain
Alvin_2289	COG0284	orotidine-5'-phosphate decarboxylase activity
Alvin_2290	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Alvin_2294	COG1328	CTP reductase activity
Alvin_2294	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Alvin_2309	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Alvin_2311	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Alvin_2315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Alvin_2316	COG0784	Response regulator, receiver
Alvin_2316	COG2205	protein histidine kinase activity
Alvin_2316	COG5002	protein histidine kinase activity
Alvin_2319	COG0784	Response regulator, receiver
Alvin_2319	COG2205	protein histidine kinase activity
Alvin_2319	COG5002	protein histidine kinase activity
Alvin_2325	COG2960	long-chain fatty acid transporting porin activity
Alvin_2328	COG0004	ammonium transporteR
Alvin_2332	COG0137	argininosuccinate synthase activity
Alvin_2335	COG0513	Belongs to the DEAD box helicase family
Alvin_2337	COG0203	ribosomal protein L17
Alvin_2338	COG0202	RNA polymerase activity
Alvin_2339	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Alvin_2340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Alvin_2341	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Alvin_2342	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Alvin_2343	COG0201	protein transport
Alvin_2344	COG0200	Binds to the 23S rRNA
Alvin_2345	COG1841	ribosomal large subunit assembly
Alvin_2346	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Alvin_2347	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Alvin_2348	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Alvin_2349	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Alvin_2350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Alvin_2351	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Alvin_2352	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Alvin_2353	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Alvin_2354	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Alvin_2355	COG0255	Belongs to the universal ribosomal protein uL29 family
Alvin_2356	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Alvin_2357	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Alvin_2358	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Alvin_2359	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Alvin_2360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Alvin_2361	COG0089	rRNA binding
Alvin_2362	COG0088	Forms part of the polypeptide exit tunnel
Alvin_2363	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Alvin_2364	COG0051	transcription antitermination factor activity, RNA binding
Alvin_2365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Alvin_2366	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Alvin_2367	COG0049	tRNA binding
Alvin_2368	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Alvin_2369	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Alvin_2370	COG0085	RNA polymerase activity
Alvin_2371	COG0222	ribosome binding
Alvin_2372	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Alvin_2373	COG0081	regulation of translation
Alvin_2374	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Alvin_2376	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Alvin_2377	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Alvin_2380	COG0193	aminoacyl-tRNA hydrolase activity
Alvin_2381	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Alvin_2382	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Alvin_2383	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Alvin_2385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Alvin_2386	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Alvin_2392	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Alvin_2394	COG3706	GGDEF domain
Alvin_2394	COG0745	RESPONSE REGULATOR receiver
Alvin_2395	COG5002	protein histidine kinase activity
Alvin_2395	COG0784	Response regulator, receiver
Alvin_2395	COG2205	protein histidine kinase activity
Alvin_2396	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Alvin_2397	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Alvin_2398	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Alvin_2408	COG0582	viral genome integration into host DNA
Alvin_2410	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Alvin_2411	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Alvin_2412	COG1007	ATP synthesis coupled electron transport
Alvin_2420	COG0713	ATP synthesis coupled electron transport
Alvin_2422	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_2423	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Alvin_2426	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Alvin_2427	COG0649	NAD binding
Alvin_2428	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_2429	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_2430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Alvin_2432	COG0149	triose-phosphate isomerase activity
Alvin_2433	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Alvin_2438	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Alvin_2439	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Alvin_2440	COG0583	DNA-binding transcription factor activity
Alvin_2441	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Alvin_2442	COG4208	sulfate ABC transporter
Alvin_2443	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Alvin_2444	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Alvin_2445	COG0583	DNA-binding transcription factor activity
Alvin_2446	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Alvin_2447	COG0175	sulfate reduction
Alvin_2449	COG2895	sulfate adenylyltransferase (ATP) activity
Alvin_2450	COG0709	Synthesizes selenophosphate from selenide and ATP
Alvin_2451	COG3383	formate dehydrogenase (NAD+) activity
Alvin_2451	COG0243	molybdopterin cofactor binding
Alvin_2452	COG3383	formate dehydrogenase (NAD+) activity
Alvin_2452	COG0243	molybdopterin cofactor binding
Alvin_2453	COG0437	4 iron, 4 sulfur cluster binding
Alvin_2454	COG2864	formate dehydrogenase
Alvin_2460	COG1720	tRNA m6t6A37 methyltransferase activity
Alvin_2461	COG2201	protein-glutamate methylesterase activity
Alvin_2462	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Alvin_2462	COG1776	CheC inhibitor of MCP methylation
Alvin_2463	COG2203	Gaf domain
Alvin_2463	COG4251	negative regulation of phosphorylation
Alvin_2463	COG3706	GGDEF domain
Alvin_2463	COG5001	Diguanylate cyclase
Alvin_2464	COG0840	transmembrane signaling receptor activity
Alvin_2466	COG2201	protein-glutamate methylesterase activity
Alvin_2468	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Alvin_2470	COG0643	Histidine kinase
Alvin_2470	COG2198	Histidine kinase
Alvin_2472	COG0745	RESPONSE REGULATOR receiver
Alvin_2473	COG0840	transmembrane signaling receptor activity
Alvin_2474	COG1366	Belongs to the anti-sigma-factor antagonist family
Alvin_2475	COG1366	Belongs to the anti-sigma-factor antagonist family
Alvin_2476	COG2172	sigma factor antagonist activity
Alvin_2477	COG2172	sigma factor antagonist activity
Alvin_2480	COG0745	RESPONSE REGULATOR receiver
Alvin_2481	COG2925	Exonuclease
Alvin_2482	COG0335	large ribosomal subunit rRNA binding
Alvin_2483	COG0336	Belongs to the RNA methyltransferase TrmD family
Alvin_2484	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Alvin_2485	COG0228	four-way junction DNA binding
Alvin_2486	COG0750	zinc metalloprotease
Alvin_2489	COG3302	dmso reductase anchor subunit
Alvin_2490	COG0437	4 iron, 4 sulfur cluster binding
Alvin_2491	COG0243	molybdopterin cofactor binding
Alvin_2493	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Alvin_2499	COG1271	oxidase subunit
Alvin_2500	COG1294	oxidase, subunit
Alvin_2502	COG2885	chlorophyll binding
Alvin_2502	COG3047	cAMP biosynthetic process
Alvin_2505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Alvin_2508	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Alvin_2513	COG0784	Response regulator, receiver
Alvin_2513	COG5002	protein histidine kinase activity
Alvin_2513	COG2205	protein histidine kinase activity
Alvin_2514	COG2201	protein-glutamate methylesterase activity
Alvin_2516	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Alvin_2517	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Alvin_2518	COG3830	Belongs to the UPF0237 family
Alvin_2518	COG0560	Phosphoserine phosphatase
Alvin_2519	COG0312	modulator of DNA gyrase
Alvin_2520	COG0312	modulator of DNA gyrase
Alvin_2521	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Alvin_2523	COG1530	ribonuclease E activity
Alvin_2524	COG0424	maF-like protein
Alvin_2525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Alvin_2526	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Alvin_2534	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Alvin_2535	COG4636	protein conserved in cyanobacteria
Alvin_2536	COG2951	lytic endotransglycosylase activity
Alvin_2538	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Alvin_2540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Alvin_2543	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Alvin_2544	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Alvin_2545	COG1850	ribulose-bisphosphate carboxylase activity
Alvin_2546	COG0432	Pfam Uncharacterised protein family UPF0047
Alvin_2556	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Alvin_2561	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Alvin_2562	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Alvin_2564	COG0500	methyltransferase
Alvin_2565	COG0142	geranyltranstransferase activity
Alvin_2569	COG1562	ergosterol biosynthetic process
Alvin_2570	COG1233	COG1233 Phytoene dehydrogenase and related
Alvin_2573	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Alvin_2574	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Alvin_2581	COG2205	protein histidine kinase activity
Alvin_2582	COG0745	RESPONSE REGULATOR receiver
Alvin_2584	COG1358	cellular component organization or biogenesis
Alvin_2591	COG2310	stress, protein
Alvin_2596	COG1943	Transposase
Alvin_2597	COG0675	Transposase, IS605 OrfB family
Alvin_2598	COG1648	precorrin-2 dehydrogenase activity
Alvin_2598	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Alvin_2599	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Alvin_2600	COG0425	Belongs to the sulfur carrier protein TusA family
Alvin_2601	COG2210	Belongs to the sulfur carrier protein TusA family
Alvin_2602	COG0028	Belongs to the TPP enzyme family
Alvin_2603	COG4251	negative regulation of phosphorylation
Alvin_2604	COG0784	Response regulator, receiver
Alvin_2606	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Alvin_2609	COG0438	transferase activity, transferring glycosyl groups
Alvin_2610	COG0438	transferase activity, transferring glycosyl groups
Alvin_2611	COG0408	coproporphyrinogen oxidase activity
Alvin_2613	COG0745	RESPONSE REGULATOR receiver
Alvin_2614	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Alvin_2615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Alvin_2619	COG0745	RESPONSE REGULATOR receiver
Alvin_2625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Alvin_2627	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Alvin_2633	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Alvin_2639	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Alvin_2640	COG1429	ligase activity, forming nitrogen-metal bonds
Alvin_2641	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Alvin_2642	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Alvin_2645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Alvin_2646	COG0644	oxidoreductase
Alvin_2649	COG1136	(ABC) transporter
Alvin_2649	COG0577	efflux transmembrane transporter activity
Alvin_2654	COG0793	Belongs to the peptidase S41A family
Alvin_2658	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Alvin_2660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Alvin_2661	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Alvin_2665	COG0505	Belongs to the CarA family
Alvin_2666	COG2205	protein histidine kinase activity
Alvin_2666	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Alvin_2668	COG2166	iron-sulfur cluster assembly
Alvin_2673	COG4657	Part of a membrane complex involved in electron transport
Alvin_2676	COG4658	electron transport chain
Alvin_2679	COG2914	Belongs to the UPF0125 (RnfH) family
Alvin_2680	COG0704	Plays a role in the regulation of phosphate uptake
Alvin_2682	COG4535	Mg2 and Co2 transporter CorC
Alvin_2683	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Alvin_2684	COG1702	phosphate starvation-inducible protein PhoH
Alvin_2685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Alvin_2687	COG1584	GPR1 FUN34 yaaH family protein
Alvin_2689	COG0714	Associated with various cellular activities
Alvin_2701	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Alvin_2705	COG2703	oxygen carrier activity
Alvin_2706	COG0590	tRNA wobble adenosine to inosine editing
Alvin_2707	COG0519	Catalyzes the synthesis of GMP from XMP
Alvin_2707	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Alvin_2708	COG0517	IMP dehydrogenase activity
Alvin_2708	COG0516	GMP reductase activity
Alvin_2709	COG1570	exodeoxyribonuclease VII activity
Alvin_2711	COG0488	(ABC) transporter
Alvin_2714	COG0058	SHG alpha-glucan phosphorylase activity
Alvin_2715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Alvin_2716	COG0318	PFAM AMP-dependent synthetase and ligase
Alvin_2716	COG0204	Acyl-transferase
Alvin_2721	COG0693	protein deglycase activity
Alvin_2722	COG0167	dihydroorotate dehydrogenase activity
Alvin_2725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Alvin_2726	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Alvin_2728	COG2022	thiamine diphosphate biosynthetic process
Alvin_2729	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Alvin_2730	COG1122	ATPase activity
Alvin_2731	COG0390	transport system, permease component
Alvin_2732	COG0579	oxidoreductase
Alvin_2733	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Alvin_2739	COG0166	Belongs to the GPI family
Alvin_2740	COG0583	DNA-binding transcription factor activity
Alvin_2749	COG4451	ribulose bisphosphate carboxylase, small
Alvin_2750	COG1850	ribulose-bisphosphate carboxylase activity
Alvin_2752	COG0659	secondary active sulfate transmembrane transporter activity
Alvin_2753	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Alvin_2754	COG0297	glycogen (starch) synthase activity
Alvin_2755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Alvin_2756	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Alvin_2757	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Alvin_2758	COG0617	tRNA 3'-terminal CCA addition
Alvin_2761	COG0602	queuosine metabolic process
Alvin_2762	COG0720	synthase
Alvin_2763	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Alvin_2765	COG3909	cytochrome
Alvin_2767	COG0513	Belongs to the DEAD box helicase family
Alvin_2768	COG0724	RNA recognition motif
Alvin_2769	COG1151	hydroxylamine reductase activity
Alvin_2771	COG3956	TIGRFAM MazG family protein
Alvin_2774	COG0714	Associated with various cellular activities
Alvin_2775	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Alvin_2776	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Alvin_2780	COG2814	Major facilitator Superfamily
Alvin_2785	COG0464	growth
Alvin_2786	COG1404	Belongs to the peptidase S8 family
Alvin_2789	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Alvin_2790	COG0131	Imidazoleglycerol-phosphate dehydratase
Alvin_2791	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Alvin_2792	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Alvin_2793	COG0140	phosphoribosyl-ATP diphosphatase activity
Alvin_2795	COG0583	DNA-binding transcription factor activity
Alvin_2799	COG0298	carbon dioxide binding
Alvin_2800	COG2813	Specifically methylates the guanine in position
Alvin_2801	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Alvin_2805	COG0840	transmembrane signaling receptor activity
Alvin_2805	COG3290	protein histidine kinase activity
Alvin_2817	COG1752	Esterase of the alpha-beta hydrolase superfamily
Alvin_2819	COG0189	ligase activity
Alvin_2820	COG1032	radical SAM domain protein
Alvin_2821	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Alvin_2824	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Alvin_2830	COG0569	domain protein
Alvin_2830	COG0189	ligase activity
Alvin_2833	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Alvin_2835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Alvin_2836	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Alvin_2839	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Alvin_2840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Alvin_2841	COG1127	ABC transporter
Alvin_2843	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Alvin_2846	COG1137	ATPase activity
Alvin_2851	COG1660	Displays ATPase and GTPase activities
Alvin_2853	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Alvin_2854	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Alvin_2855	COG2239	Acts as a magnesium transporter
Alvin_2856	COG0154	amidase activity
Alvin_2857	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Alvin_2858	COG1077	Cell shape determining protein MreB Mrl
Alvin_2859	COG1792	Involved in formation and maintenance of cell shape
Alvin_2860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Alvin_2861	COG0768	penicillin binding
Alvin_2862	COG0772	Belongs to the SEDS family
Alvin_2863	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Alvin_2864	COG1686	Belongs to the peptidase S11 family
Alvin_2865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Alvin_2867	COG0321	lipoyl(octanoyl) transferase activity
Alvin_2873	COG4636	protein conserved in cyanobacteria
Alvin_2877	COG1999	signal sequence binding
Alvin_2878	COG2847	Copper chaperone PCu(A)C
Alvin_2883	COG1215	transferase activity, transferring glycosyl groups
Alvin_2884	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Alvin_2885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Alvin_2886	COG0742	ribosomal rna small subunit methyltransferase
Alvin_2887	COG0612	Peptidase, M16
Alvin_2888	COG0612	Peptidase, M16
Alvin_2889	COG0552	protein localization to endoplasmic reticulum
Alvin_2890	COG2884	Cell division ATP-binding protein ftsE
Alvin_2891	COG2177	Part of the ABC transporter FtsEX involved in
Alvin_2893	COG1872	DUF167
Alvin_2897	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Alvin_2898	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Alvin_2900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Alvin_2901	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Alvin_2905	COG0006	proline dipeptidase activity
Alvin_2906	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Alvin_2907	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Alvin_2908	COG0205	6-phosphofructokinase activity
Alvin_2909	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Alvin_2910	COG0315	cyclic pyranopterin monophosphate synthase activity
Alvin_2911	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Alvin_2912	COG0784	Response regulator, receiver
Alvin_2912	COG2205	protein histidine kinase activity
Alvin_2912	COG5002	protein histidine kinase activity
Alvin_2915	COG0835	chemotaxis
Alvin_2916	COG1360	Flagellar Motor Protein
Alvin_2917	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Alvin_2918	COG2201	protein-glutamate methylesterase activity
Alvin_2919	COG0643	Histidine kinase
Alvin_2919	COG2198	Histidine kinase
Alvin_2920	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Alvin_2923	COG0455	bacterial-type flagellum organization
Alvin_2926	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Alvin_2928	COG1987	bacterial-type flagellum assembly
Alvin_2943	COG1677	Flagellar hook-basal body complex protein FliE
Alvin_2944	COG2204	response regulator
Alvin_2958	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Alvin_2958	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Alvin_2959	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Alvin_2962	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Alvin_2966	COG3706	GGDEF domain
Alvin_2967	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Alvin_2968	COG1376	ErfK ybiS ycfS ynhG family protein
Alvin_2973	COG0517	IMP dehydrogenase activity
Alvin_2973	COG0516	GMP reductase activity
Alvin_2974	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Alvin_2976	COG2226	methyltransferase
Alvin_2978	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Alvin_2979	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Alvin_2981	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Alvin_2982	COG1758	RNA polymerase activity
Alvin_2983	COG0194	GDP metabolic process
Alvin_2984	COG1561	YicC-like family, N-terminal region
Alvin_2985	COG0515	serine threonine protein kinase
Alvin_2985	COG3266	domain, Protein
Alvin_2986	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Alvin_2988	COG0583	DNA-binding transcription factor activity
Alvin_2989	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Alvin_2991	COG2003	Belongs to the UPF0758 family
Alvin_2992	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Alvin_2993	COG0756	dUTP diphosphatase activity
Alvin_2994	COG0840	transmembrane signaling receptor activity
Alvin_2995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Alvin_2997	COG2204	response regulator
Alvin_2998	COG3852	Histidine kinase
Alvin_3000	COG0174	glutamine synthetase
Alvin_3001	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Alvin_3002	COG0752	glycyl-tRNA synthetase alpha subunit
Alvin_3003	COG0751	glycine-tRNA ligase activity
Alvin_3006	COG1450	Type ii and iii secretion system protein
Alvin_3010	COG3156	type II secretion system protein K
Alvin_3012	COG2165	general secretion pathway protein
Alvin_3015	COG1459	type II secretion system
Alvin_3022	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Alvin_3023	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Alvin_3025	COG0793	Belongs to the peptidase S41A family
Alvin_3026	COG4942	peptidase
Alvin_3027	COG0640	Transcriptional regulator
Alvin_3029	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Alvin_3030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Alvin_3031	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Alvin_3036	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Alvin_3046	COG0513	Belongs to the DEAD box helicase family
Alvin_3047	COG0210	DNA helicase
Alvin_3048	COG0539	negative regulation of cytoplasmic translation
Alvin_3049	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Alvin_3050	COG0254	rRNA binding
Alvin_3051	COG0281	malic enzyme
Alvin_3052	COG0372	Belongs to the citrate synthase family
Alvin_3059	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Alvin_3060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Alvin_3064	COG2084	Dehydrogenase
Alvin_3065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Alvin_3071	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Alvin_3075	COG0445	tRNA wobble uridine modification
Alvin_3076	COG0714	Associated with various cellular activities
Alvin_3077	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Alvin_3084	COG2205	protein histidine kinase activity
Alvin_3085	COG0037	tRNA processing
Alvin_3088	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Alvin_3089	COG3038	cytochrome b561
Alvin_3090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Alvin_3098	COG1074	ATP-dependent DNA helicase activity
Alvin_3099	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Alvin_3101	COG2111	Na H antiporter
Alvin_3101	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Alvin_3102	COG1006	Multisubunit Na H antiporter MnhC subunit
Alvin_3103	COG0651	ATP synthesis coupled electron transport
Alvin_3104	COG1863	multisubunit Na H antiporter MnhE subunit
Alvin_3105	COG2212	antiporter activity
Alvin_3106	COG1320	monovalent cation:proton antiporter activity
Alvin_3108	COG0004	ammonium transporteR
Alvin_3113	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Alvin_3114	COG0018	arginyl-trna synthetase
Alvin_3116	COG0531	amino acid
Alvin_3122	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Alvin_3123	COG0706	membrane insertase activity
Alvin_3125	COG0594	ribonuclease P activity
Alvin_3126	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Alvin_3135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Alvin_3145	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Alvin_3146	COG1518	maintenance of DNA repeat elements
Alvin_3147	COG2916	Histone family protein nucleoid-structuring protein H-NS
Alvin_3164	COG1690	Belongs to the RtcB family
Alvin_3175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Alvin_3179	COG0514	ATP-dependent DNA helicase (RecQ)
Alvin_3186	COG4974	Belongs to the 'phage' integrase family
Alvin_3188	COG0489	protein tyrosine kinase activity
Alvin_3234	COG3012	SEC-C Motif Domain Protein
Alvin_3238	COG0598	Magnesium transport protein CorA
Alvin_3240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Alvin_3246	COG0758	DNA mediated transformation
Alvin_3259	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Alvin_3267	COG0776	regulation of translation
Alvin_3276	COG5377	YqaJ viral recombinase family
Alvin_3277	COG0714	Associated with various cellular activities