locus-tag	class	description
SD28_00005	COG0339	signal peptide processing
SD28_00010	COG0792	nuclease activity
SD28_00035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SD28_00045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SD28_00050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SD28_00080	COG0586	Pfam SNARE associated Golgi protein
SD28_00125	COG0501	Belongs to the peptidase M48B family
SD28_00160	COG0730	response to heat
SD28_00175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD28_00215	COG1183	phosphatidylcholine synthase activity
SD28_00220	COG4401	Chorismate mutase type I
SD28_00250	COG0758	DNA mediated transformation
SD28_00295	COG2890	protein-(glutamine-N5) methyltransferase activity
SD28_00315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD28_00320	COG2814	Major facilitator Superfamily
SD28_00345	COG0552	protein localization to endoplasmic reticulum
SD28_00365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SD28_00370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SD28_00375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SD28_00385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SD28_00385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SD28_00430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SD28_00435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD28_00480	COG0642	Histidine kinase
SD28_00485	COG1090	epimerase
SD28_00490	COG1271	oxidase subunit
SD28_00495	COG1294	oxidase, subunit
SD28_00520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SD28_00525	COG2252	PERMEase
SD28_00535	COG1051	belongs to the nudix hydrolase family
SD28_00560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SD28_00570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD28_00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SD28_00580	COG0850	regulation of cytokinetic process
SD28_00590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SD28_00595	COG1127	ABC transporter
SD28_00600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD28_00605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD28_00620	COG2066	Belongs to the glutaminase family
SD28_00630	COG3040	lipid binding
SD28_00635	COG0814	amino acid
SD28_00695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SD28_00735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SD28_00735	COG0564	pseudouridine synthase activity
SD28_00740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SD28_00765	COG0195	Participates in both transcription termination and antitermination
SD28_00765	COG2251	uridine kinase activity
SD28_00785	COG0606	chelatase, subunit chli
SD28_00805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SD28_00815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD28_00830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SD28_00860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SD28_00865	COG1053	succinate dehydrogenase
SD28_00870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SD28_00875	COG2009	succinate dehydrogenase
SD28_00885	COG2223	nitrite transmembrane transporter activity
SD28_00890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SD28_00895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SD28_00905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD28_00945	COG1984	allophanate hydrolase subunit 2
SD28_00950	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SD28_00965	COG0589	response to stress
SD28_00970	COG0481	GTPase activity
SD28_00975	COG0482	sulfurtransferase activity
SD28_00985	COG0242	peptide deformylase activity
SD28_01000	COG0307	riboflavin synthase, alpha
SD28_01005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD28_01005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD28_01015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD28_01020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SD28_01025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SD28_01045	COG0857	belongs to the CobB CobQ family
SD28_01045	COG0280	phosphate acetyltransferase
SD28_01055	COG0629	single-stranded DNA binding
SD28_01060	COG2137	regulation of response to DNA damage stimulus
SD28_01075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SD28_01085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SD28_01085	COG0616	signal peptide processing
SD28_01135	COG0135	phosphoribosylanthranilate isomerase activity
SD28_01135	COG0134	indole-3-glycerol-phosphate synthase activity
SD28_01140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD28_01145	COG0531	amino acid
SD28_01155	COG0167	dihydroorotate dehydrogenase activity
SD28_01235	COG1605	Chorismate mutase
SD28_01235	COG0287	Prephenate dehydrogenase
SD28_01240	COG1490	D-aminoacyl-tRNA deacylase activity
SD28_01255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SD28_01290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SD28_01295	COG0488	(ABC) transporter
SD28_01310	COG0512	Glutamine amidotransferase of anthranilate synthase
SD28_01315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD28_01330	COG1530	ribonuclease E activity
SD28_01340	COG0592	DNA-directed DNA polymerase activity
SD28_01355	COG0540	Belongs to the ATCase OTCase family
SD28_01360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD28_01365	COG0505	Belongs to the CarA family
SD28_01380	COG0557	exoribonuclease II activity
SD28_01410	COG1116	anion transmembrane transporter activity
SD28_01425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SD28_01450	COG0762	integral membrane protein
SD28_01455	COG1872	DUF167
SD28_01465	COG0189	ligase activity
SD28_01470	COG0658	competence protein
SD28_01470	COG2333	competence protein COMEC
SD28_01535	COG0814	amino acid
SD28_01545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SD28_01550	COG0531	amino acid
SD28_01555	COG4178	(ABC) transporter
SD28_01560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SD28_01575	COG0574	Belongs to the PEP-utilizing enzyme family
SD28_01575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SD28_01580	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SD28_01600	COG1560	Kdo2-lipid A biosynthetic process
SD28_01605	COG1560	Kdo2-lipid A biosynthetic process
SD28_01610	COG0706	membrane insertase activity
SD28_01615	COG0594	ribonuclease P activity
SD28_01620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SD28_01625	COG0814	amino acid
SD28_01630	COG0357	Ribosomal RNA small subunit methyltransferase G
SD28_01635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SD28_01645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SD28_01675	COG0542	response to heat
SD28_01705	COG0204	Acyl-transferase
SD28_01715	COG0009	L-threonylcarbamoyladenylate synthase
SD28_01725	COG0590	tRNA wobble adenosine to inosine editing
SD28_01755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SD28_01770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SD28_01775	COG2814	Major facilitator Superfamily
SD28_01795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SD28_01800	COG1538	Outer membrane efflux protein
SD28_01810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SD28_01815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SD28_01815	COG0047	phosphoribosylformylglycinamidine synthase activity
SD28_01820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD28_01835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SD28_01855	COG2814	Major facilitator Superfamily
SD28_01880	COG0076	glutamate decarboxylase activity
SD28_01890	COG0527	aspartate kinase activity
SD28_01940	COG4115	mRNA cleavage
SD28_01945	COG2161	toxin-antitoxin pair type II binding
SD28_01965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD28_01970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD28_01985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SD28_01995	COG1034	ATP synthesis coupled electron transport
SD28_02005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD28_02010	COG0839	Belongs to the complex I subunit 6 family
SD28_02015	COG0713	ATP synthesis coupled electron transport
SD28_02055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SD28_02065	COG0714	Associated with various cellular activities
SD28_02080	COG2304	oxidoreductase activity
SD28_02085	COG2304	oxidoreductase activity
SD28_02115	COG0525	valine-tRNA ligase activity
SD28_02130	COG0138	bifunctional purine biosynthesis protein purh
SD28_02140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SD28_02155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD28_02160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD28_02165	COG3842	ATPase activity
SD28_02175	COG2814	Major facilitator Superfamily
SD28_02190	COG1295	ribonuclease BN
SD28_02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SD28_02225	COG1294	oxidase, subunit
SD28_02230	COG1271	oxidase subunit
SD28_02235	COG2814	Major facilitator Superfamily
SD28_02240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SD28_02250	COG0052	Belongs to the universal ribosomal protein uS2 family
SD28_02270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SD28_02275	COG4589	Belongs to the CDS family
SD28_02280	COG0756	dUTP diphosphatase activity
SD28_02285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SD28_02295	COG0049	tRNA binding
SD28_02325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SD28_02330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SD28_02335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SD28_02345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SD28_02365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SD28_02375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SD28_02380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SD28_02410	COG0201	protein transport
SD28_02420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SD28_02460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SD28_02465	COG0285	dihydrofolate synthase activity
SD28_02470	COG0802	atpase or kinase
SD28_02480	COG0728	peptidoglycan biosynthetic process
SD28_02485	COG2918	glutathione biosynthetic process
SD28_02495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SD28_02515	COG0210	DNA helicase
SD28_02535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SD28_02565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SD28_02575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SD28_02585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SD28_02590	COG0081	regulation of translation
SD28_02595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SD28_02620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SD28_02630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SD28_02655	COG4974	Belongs to the 'phage' integrase family
SD28_02690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD28_02720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SD28_02740	COG1674	ftsk spoiiie
SD28_02750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SD28_02760	COG0833	amino acid
SD28_02765	COG2945	thiolester hydrolase activity
SD28_02770	COG1494	fructose-1,6-bisphosphatase
SD28_02775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD28_02815	COG2890	protein-(glutamine-N5) methyltransferase activity
SD28_02860	COG0084	hydrolase, TatD family'
SD28_02880	COG0730	response to heat
SD28_02885	COG1131	(ABC) transporter
SD28_02890	COG0842	Transport permease protein
SD28_02895	COG0463	Glycosyl transferase, family 2
SD28_02905	COG2996	Protein conserved in bacteria
SD28_02910	COG1280	lysine exporter protein (LysE YggA)
SD28_02915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SD28_02940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SD28_02955	COG2983	Belongs to the UPF0260 family
SD28_02970	COG0436	Aminotransferase
SD28_03005	COG2166	iron-sulfur cluster assembly
SD28_03115	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SD28_03135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SD28_03140	COG0814	amino acid
SD28_03210	COG0237	dephospho-CoA kinase activity
SD28_03220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD28_03230	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD28_03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD28_03285	COG2814	Major facilitator Superfamily
SD28_03320	COG2814	Major facilitator Superfamily
SD28_03360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD28_03380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SD28_03400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SD28_03415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SD28_03425	COG0187	DNA topoisomerase II activity
SD28_03430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD28_03435	COG0204	Acyl-transferase
SD28_03435	COG0318	PFAM AMP-dependent synthetase and ligase
SD28_03440	COG0275	rRNA processing
SD28_03445	COG3116	cell division
SD28_03455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SD28_03475	COG0572	uridine kinase
SD28_03515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SD28_03520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD28_03525	COG0814	amino acid
SD28_03535	COG0156	8-amino-7-oxononanoate synthase activity
SD28_03580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SD28_03580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SD28_03585	COG0483	inositol monophosphate 1-phosphatase activity
SD28_03590	COG2855	membrane
SD28_03615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SD28_03625	COG1058	Belongs to the CinA family
SD28_03625	COG1546	Belongs to the CinA family
SD28_03655	COG1464	Belongs to the NlpA lipoprotein family
SD28_03705	COG1862	Preprotein translocase
SD28_03710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD28_03715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD28_03725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SD28_03745	COG0252	asparaginase activity
SD28_03750	COG0288	reversible hydration of carbon dioxide
SD28_03765	COG0740	serine-type endopeptidase activity
SD28_03770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SD28_03775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SD28_03790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SD28_03810	COG1923	regulation of RNA biosynthetic process
SD28_03815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SD28_03820	COG0330	HflC and HflK could
SD28_03825	COG0330	HflC and HflK could
SD28_03830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD28_03840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SD28_03845	COG0346	lactoylglutathione lyase activity
SD28_03860	COG1611	Belongs to the LOG family
SD28_03870	COG0517	IMP dehydrogenase activity
SD28_03870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SD28_03875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SD28_03890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD28_03900	COG1446	asparaginase
SD28_03940	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SD28_03965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SD28_03995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SD28_04000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SD28_04005	COG0562	UDP-galactopyranose mutase
SD28_04010	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SD28_04015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SD28_04020	COG0443	Heat shock 70 kDa protein
SD28_04035	COG0156	8-amino-7-oxononanoate synthase activity
SD28_04045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SD28_04060	COG1566	PFAM secretion protein HlyD family protein
SD28_04065	COG2814	Major facilitator Superfamily
SD28_04070	COG0318	PFAM AMP-dependent synthetase and ligase
SD28_04080	COG3104	oligopeptide transport
SD28_04085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SD28_04105	COG1127	ABC transporter
SD28_04110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD28_04115	COG2992	FlgJ-related protein
SD28_04120	COG0564	pseudouridine synthase activity
SD28_04125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD28_04150	COG0560	Phosphoserine phosphatase
SD28_04175	COG0531	amino acid
SD28_04180	COG0077	Prephenate dehydratase
SD28_04180	COG1605	Chorismate mutase
SD28_04190	COG1760	l-serine dehydratase
SD28_04195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SD28_04200	COG0316	Belongs to the HesB IscA family
SD28_04205	COG2151	metal-sulfur cluster biosynthetic enzyme
SD28_04210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SD28_04215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SD28_04235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SD28_04240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SD28_04250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SD28_04265	COG0445	tRNA wobble uridine modification
SD28_04305	COG0556	nucleotide-excision repair
SD28_04310	COG2925	Exonuclease
SD28_04335	COG1137	ATPase activity
SD28_04340	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD28_04345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SD28_04360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SD28_04370	COG0095	Lipoate-protein ligase
SD28_04375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SD28_04400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD28_04405	COG0189	ligase activity
SD28_04410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD28_04420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD28_04420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SD28_04430	COG0318	PFAM AMP-dependent synthetase and ligase
SD28_04435	COG0512	Glutamine amidotransferase of anthranilate synthase
SD28_04435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD28_04440	COG0512	Glutamine amidotransferase of anthranilate synthase
SD28_04440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SD28_04450	COG0667	Aldo Keto reductase
SD28_04455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SD28_04490	COG1610	YqeY-like protein
SD28_04495	COG0358	DNA primase activity
SD28_04510	COG3028	Belongs to the UPF0307 family
SD28_04515	COG0142	geranyltranstransferase activity
SD28_04545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SD28_04550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SD28_04555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD28_04560	COG0697	spore germination
SD28_04565	COG0482	sulfurtransferase activity
SD28_04570	COG0425	Belongs to the sulfur carrier protein TusA family
SD28_04575	COG2835	tetraacyldisaccharide 4'-kinase activity
SD28_04590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SD28_04595	COG0513	Belongs to the DEAD box helicase family
SD28_04615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD28_04615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD28_04635	COG2814	Major facilitator Superfamily
SD28_04660	COG0156	8-amino-7-oxononanoate synthase activity
SD28_04665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SD28_04670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD28_04680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD28_04685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SD28_04690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SD28_04695	COG1530	ribonuclease E activity
SD28_04715	COG0586	Pfam SNARE associated Golgi protein
SD28_04720	COG0586	Pfam SNARE associated Golgi protein
SD28_04730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SD28_04740	COG0084	hydrolase, TatD family'
SD28_04745	COG0751	glycine-tRNA ligase activity
SD28_04750	COG2814	Major facilitator Superfamily
SD28_04755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SD28_04765	COG1322	Protein conserved in bacteria
SD28_04775	COG1335	isochorismatase
SD28_04785	COG0697	spore germination
SD28_04790	COG0354	folic acid binding
SD28_04795	COG0210	DNA helicase
SD28_04800	COG2814	Major facilitator Superfamily
SD28_04820	COG0659	secondary active sulfate transmembrane transporter activity
SD28_04840	COG2921	Belongs to the UPF0250 family
SD28_04845	COG1686	Belongs to the peptidase S11 family
SD28_04850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SD28_04880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SD28_04885	COG2867	negative regulation of translational initiation
SD28_04895	COG1943	Transposase
SD28_04915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SD28_04920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SD28_04930	COG0730	response to heat
SD28_04955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD28_04965	COG0517	IMP dehydrogenase activity
SD28_04965	COG0516	GMP reductase activity
SD28_04990	COG0259	pyridoxamine-phosphate oxidase activity
SD28_05005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD28_05010	COG2814	Major facilitator Superfamily
SD28_05045	COG0799	negative regulation of ribosome biogenesis
SD28_05055	COG0210	DNA helicase
SD28_05065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SD28_05065	COG0678	peroxiredoxin activity
SD28_05070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SD28_05090	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SD28_05095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SD28_05100	COG0450	alkyl hydroperoxide reductase
SD28_05110	COG2824	Alkylphosphonate utilization operon protein PhnA
SD28_05115	COG0302	gtp cyclohydrolase
SD28_05120	COG0513	Belongs to the DEAD box helicase family
SD28_05135	COG0823	Involved in the tonB-independent uptake of proteins
SD28_05140	COG1472	Belongs to the glycosyl hydrolase 3 family
SD28_05145	COG1028	Short-chain dehydrogenase reductase Sdr
SD28_05150	COG4689	acetoacetate decarboxylase
SD28_05160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD28_05175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SD28_05185	COG2255	four-way junction helicase activity
SD28_05205	COG2814	Major facilitator Superfamily
SD28_05210	COG1904	glucuronate isomerase
SD28_05230	COG0246	Mannitol dehydrogenase
SD28_05245	COG3104	oligopeptide transport
SD28_05250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD28_05255	COG0708	Exodeoxyribonuclease III
SD28_05285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD28_05285	COG0072	phenylalanine-tRNA ligase activity
SD28_05295	COG0489	protein tyrosine kinase activity
SD28_05305	COG0668	transmembrane transport
SD28_05320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SD28_05325	COG1678	Uncharacterized ACR, COG1678
SD28_05355	COG0719	Fe-S assembly protein
SD28_05360	COG0396	ATPase activity
SD28_05365	COG0719	Fe-S assembly protein
SD28_05370	COG1959	2 iron, 2 sulfur cluster binding
SD28_05375	COG0569	domain protein
SD28_05380	COG0531	amino acid
SD28_05390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SD28_05425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SD28_05425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SD28_05430	COG0386	Belongs to the glutathione peroxidase family
SD28_05435	COG0077	Prephenate dehydratase
SD28_05435	COG1605	Chorismate mutase
SD28_05445	COG2264	protein methyltransferase activity
SD28_05460	COG0415	Belongs to the DNA photolyase family
SD28_05465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SD28_05470	COG2814	Major facilitator Superfamily
SD28_05475	COG0531	amino acid
SD28_05485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SD28_05500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD28_05530	COG0563	adenylate kinase activity
SD28_05535	COG0277	FAD linked oxidase domain protein
SD28_05550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SD28_05560	COG1214	PFAM Peptidase M22, glycoprotease
SD28_05570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SD28_05600	COG1702	phosphate starvation-inducible protein PhoH
SD28_05615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SD28_05630	COG0561	phosphatase activity
SD28_05645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD28_05650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD28_05655	COG3079	Belongs to the UPF0149 family
SD28_05710	COG2814	Major facilitator Superfamily
SD28_05715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD28_05730	COG4536	flavin adenine dinucleotide binding
SD28_05740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SD28_05760	COG1187	pseudouridine synthase activity
SD28_05780	COG0359	binds to the 23S rRNA
SD28_05785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD28_05790	COG0360	Binds together with S18 to 16S ribosomal RNA
SD28_05795	COG0408	coproporphyrinogen oxidase activity
SD28_05810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SD28_05845	COG0037	tRNA processing
SD28_05885	COG4988	ABC transporter
SD28_05890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SD28_05895	COG1301	dicarboxylic acid transport
SD28_05900	COG0251	oxidation-reduction process
SD28_05905	COG2271	Major facilitator Superfamily
SD28_05915	COG4572	Cation transport regulator
SD28_05920	COG1028	Short-chain dehydrogenase reductase Sdr
SD28_05930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SD28_05955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SD28_05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD28_05985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SD28_06005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SD28_06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SD28_06020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SD28_06025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD28_06030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD28_06035	COG1028	Short-chain dehydrogenase reductase Sdr
SD28_06040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SD28_06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SD28_06075	COG0126	phosphoglycerate kinase activity
SD28_06080	COG0469	pyruvate kinase activity
SD28_06085	COG0191	fructose-bisphosphate aldolase activity
SD28_06105	COG3842	ATPase activity
SD28_06110	COG1176	ABC-type spermidine putrescine transport system, permease component I
SD28_06115	COG1177	transmembrane transport
SD28_06135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SD28_06165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD28_06190	COG0517	IMP dehydrogenase activity
SD28_06190	COG0516	GMP reductase activity
SD28_06195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD28_06200	COG0795	lipopolysaccharide-transporting ATPase activity
SD28_06205	COG0795	lipopolysaccharide-transporting ATPase activity
SD28_06210	COG0612	Peptidase, M16
SD28_06220	COG0742	ribosomal rna small subunit methyltransferase
SD28_06225	COG2860	membrane
SD28_06235	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SD28_06240	COG0295	cytidine deaminase activity
SD28_06245	COG1278	Cold shock
SD28_06255	COG0277	FAD linked oxidase domain protein
SD28_06255	COG0247	lactate metabolic process
SD28_06260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SD28_06265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SD28_06270	COG0497	DNA recombination
SD28_06280	COG0436	Aminotransferase
SD28_06285	COG1940	carbohydrate kinase activity
SD28_06305	COG1773	rubredoxin
SD28_06310	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SD28_06325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SD28_06345	COG0012	GTP binding
SD28_06360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD28_06370	COG0509	glycine decarboxylation via glycine cleavage system
SD28_06375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SD28_06380	COG1982	Orn Lys Arg decarboxylase major
SD28_06420	COG0587	DNA-directed DNA polymerase activity
SD28_06430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SD28_06440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD28_06445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD28_06455	COG0024	Methionine aminopeptidase
SD28_06465	COG0509	glycine decarboxylation via glycine cleavage system
SD28_06480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SD28_06490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SD28_06515	COG1509	lysine 2,3-aminomutase activity
SD28_06545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SD28_06550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD28_06590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SD28_06595	COG2878	Part of a membrane complex involved in electron transport
SD28_06600	COG2999	glutathione oxidoreductase activity
SD28_06640	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SD28_06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SD28_06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD28_06730	COG2089	acid synthase
SD28_06740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD28_06750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SD28_06760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD28_06765	COG1086	Polysaccharide biosynthesis protein
SD28_06785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SD28_06795	COG1086	Polysaccharide biosynthesis protein
SD28_06800	COG1643	Atp-dependent helicase
SD28_06815	COG1393	Belongs to the ArsC family
SD28_06820	COG0318	PFAM AMP-dependent synthetase and ligase
SD28_06825	COG1960	acyl-CoA dehydrogenase activity
SD28_06830	COG1024	Enoyl-CoA hydratase
SD28_06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD28_06835	COG0183	Belongs to the thiolase family
SD28_06850	COG0010	Belongs to the arginase family
SD28_06865	COG0745	RESPONSE REGULATOR receiver
SD28_06870	COG5002	protein histidine kinase activity
SD28_06885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD28_06905	COG0557	exoribonuclease II activity
SD28_06915	COG0571	ribonuclease III activity
SD28_06920	COG0681	Belongs to the peptidase S26 family
SD28_06925	COG0745	RESPONSE REGULATOR receiver
SD28_06930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD28_06935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SD28_06940	COG1519	Transferase
SD28_06945	COG0142	geranyltranstransferase activity
SD28_06950	COG1183	phosphatidylcholine synthase activity
SD28_06990	COG0492	ferredoxin-NADP+ reductase activity
SD28_07000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SD28_07025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SD28_07035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SD28_07040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD28_07045	COG0511	ligase activity, forming carbon-carbon bonds
SD28_07050	COG0439	Biotin carboxylase
SD28_07075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SD28_07095	COG2852	Protein conserved in bacteria
SD28_07130	COG0531	amino acid
SD28_07135	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SD28_07150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SD28_07155	COG0113	porphobilinogen synthase activity
SD28_07165	COG0470	DNA polymerase III
SD28_07170	COG0616	signal peptide processing
SD28_07175	COG0625	glutathione transferase activity
SD28_07180	COG2920	part of a sulfur-relay system
SD28_07185	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SD28_07190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD28_07205	COG0772	Belongs to the SEDS family
SD28_07225	COG1278	Cold shock
SD28_07300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD28_07310	COG1056	cytidyltransferase-related domain
SD28_07310	COG1051	belongs to the nudix hydrolase family
SD28_07320	COG0688	phosphatidylethanolamine metabolic process
SD28_07340	COG1994	Peptidase M50
SD28_07360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SD28_07370	COG0814	amino acid
SD28_07400	COG0531	amino acid
SD28_07405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SD28_07410	COG2081	HI0933 family
SD28_07420	COG0300	oxidoreductase activity
SD28_07425	COG1252	NADH dehydrogenase
SD28_07435	COG0459	protein refolding
SD28_07440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SD28_07465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SD28_07470	COG0248	Ppx GppA phosphatase
SD28_07550	COG0009	L-threonylcarbamoyladenylate synthase
SD28_07570	COG2226	methyltransferase
SD28_07580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SD28_07585	COG0537	adenosine 5'-monophosphoramidase activity
SD28_07590	COG1040	competence protein
SD28_07595	COG2226	methyltransferase
SD28_07605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SD28_07610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SD28_07640	COG0281	malic enzyme
SD28_07645	COG0196	riboflavin kinase activity
SD28_07650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SD28_07665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SD28_07675	COG0519	Catalyzes the synthesis of GMP from XMP
SD28_07675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SD28_07680	COG1475	DNA binding
SD28_07685	COG1192	Involved in chromosome partitioning