locus-tag	class	description
HME7025_00003	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HME7025_00004	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HME7025_00005	ENOG4107YH7	Beta-lactamase (EC 3.5.2.6)
HME7025_00019	ENOG4105KVH	Transcriptional regulator
HME7025_00029	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HME7025_00030	ENOG4108IQE	Amp-dependent synthetase and ligase
HME7025_00034	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HME7025_00035	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HME7025_00036	ENOG4105VFF	UPF0102 protein
HME7025_00037	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HME7025_00041	ENOG4107R4J	Chloride channel
HME7025_00042	ENOG4105C1J	atp-dependent rna helicase
HME7025_00045	ENOG4108Z0R	Transferase
HME7025_00046	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HME7025_00049	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
HME7025_00052	ENOG4105D52	delta-aminolevulinic acid dehydratase
HME7025_00053	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HME7025_00054	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HME7025_00055	ENOG4105K46	50S ribosomal protein l27
HME7025_00058	ENOG4105CP7	Triose-phosphate isomerase
HME7025_00059	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HME7025_00061	ENOG4108URH	decarboxylase
HME7025_00062	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HME7025_00065	ENOG4107S1E	Beta-lactamase
HME7025_00066	ENOG41067QW	Transcriptional regulator
HME7025_00110	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
HME7025_00111	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HME7025_00118	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HME7025_00119	ENOG4107QM2	Aldo Keto reductase
HME7025_00120	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HME7025_00122	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HME7025_00123	ENOG4108N5B	2-phosphosulfolactate phosphatase
HME7025_00128	ENOG4105CKK	Glycosyl transferase, family 2
HME7025_00129	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HME7025_00139	ENOG4107ZXU	DSBA oxidoreductase
HME7025_00140	ENOG4105D4P	Coproporphyrinogen iii oxidase
HME7025_00158	ENOG4107RJ1	sodium solute
HME7025_00159	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HME7025_00162	ENOG4108ZX5	transcriptional regulator
HME7025_00163	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00177	ENOG410901P	UPF0249 protein
HME7025_00179	ENOG4105CPC	Aldo Keto reductase
HME7025_00180	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HME7025_00181	ENOG4105EV8	ectoine hydroxylase
HME7025_00182	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_00183	ENOG4108RVA	ribokinase
HME7025_00189	ENOG4105CBG	Sulfatase
HME7025_00190	ENOG4105CBG	Sulfatase
HME7025_00194	ENOG4108JYZ	YitT family
HME7025_00203	ENOG4105ETE	Transcriptional regulator (LacI family
HME7025_00204	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00209	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HME7025_00211	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HME7025_00214	ENOG4105DXN	mazG family
HME7025_00215	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HME7025_00216	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HME7025_00217	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_00223	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HME7025_00224	ENOG4105CE4	GlcNAc 6-P deacetylase
HME7025_00225	ENOG4105CHM	Aminotransferase
HME7025_00229	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HME7025_00230	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HME7025_00231	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HME7025_00234	ENOG4105C1J	atp-dependent rna helicase
HME7025_00235	ENOG4105EPC	oxidoreductase
HME7025_00238	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HME7025_00241	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HME7025_00243	ENOG4105CPC	Aldo Keto reductase
HME7025_00252	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HME7025_00254	ENOG4105CJ3	phosphate transporter
HME7025_00256	ENOG4105C03	ribonuclease
HME7025_00258	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HME7025_00260	ENOG4108UUM	single-stranded DNA-binding protein
HME7025_00261	ENOG4108JU5	Magnesium and cobalt efflux protein
HME7025_00270	ENOG4108KPZ	tonB-dependent Receptor
HME7025_00274	ENOG4105G6Z	alkaline phosphatase
HME7025_00275	ENOG41080HI	glycine oxidase
HME7025_00277	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00282	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HME7025_00283	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HME7025_00284	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HME7025_00285	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HME7025_00287	ENOG4105DPW	Major facilitator superfamily MFS_1
HME7025_00288	ENOG4105CWC	Acetylornithine deacetylase
HME7025_00290	ENOG4105D2H	Uronic isomerase
HME7025_00291	ENOG4107QZW	Altronate oxidoreductase
HME7025_00297	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HME7025_00298	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HME7025_00300	ENOG4105C26	Dehydrogenase
HME7025_00310	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HME7025_00312	ENOG4105II7	pyrroline-5-carboxylate reductase
HME7025_00314	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HME7025_00315	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HME7025_00316	ENOG4107VNI	ribosomal protein l10
HME7025_00317	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HME7025_00318	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HME7025_00331	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HME7025_00333	ENOG4108SJC	Membrane
HME7025_00336	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HME7025_00337	ENOG4105CCU	oxidase (Subunit III)
HME7025_00338	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HME7025_00340	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HME7025_00346	ENOG4107SFQ	iron-sulfur binding
HME7025_00349	ENOG4107XAV	metallophosphoesterase
HME7025_00350	ENOG4108535	NAD dependent epimerase/dehydratase family
HME7025_00355	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HME7025_00356	ENOG4105BZU	Histidine kinase
HME7025_00357	ENOG4107QTF	adenylosuccinate lyase
HME7025_00358	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HME7025_00359	ENOG4105CRQ	synthase (Component I)
HME7025_00360	ENOG4105DDQ	anthranilate synthase
HME7025_00361	ENOG4107RI6	Anthranilate phosphoribosyltransferase
HME7025_00362	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HME7025_00363	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HME7025_00364	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HME7025_00365	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HME7025_00366	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HME7025_00368	ENOG4105C19	ABC transporter
HME7025_00369	ENOG4105EXC	Acyl-transferase
HME7025_00371	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HME7025_00372	ENOG4105MJ2	Competence protein
HME7025_00373	ENOG4105E6M	Sulphatase-modifying factor protein
HME7025_00374	ENOG4108JA2	transcriptioN-repair coupling factor
HME7025_00377	ENOG4105DU1	integral membrane protein, terc
HME7025_00384	ENOG4107G87	m6 family metalloprotease domain protein
HME7025_00385	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HME7025_00386	ENOG4105C5H	ABC transporter
HME7025_00387	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HME7025_00388	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HME7025_00389	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HME7025_00393	ENOG4105CV8	reductase
HME7025_00395	ENOG4105F32	YngK protein
HME7025_00396	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HME7025_00397	ENOG4105C02	permease
HME7025_00398	ENOG4108NEV	two component transcriptional regulator, LytTR family
HME7025_00399	ENOG4108HRK	Histidine kinase
HME7025_00400	ENOG4105CVJ	phosphoglycerate mutase
HME7025_00401	ENOG4105KA0	thioesterase Superfamily protein
HME7025_00404	ENOG4105DEN	Luciferase family
HME7025_00405	ENOG4108YYH	Nadph-dependent fmn reductase
HME7025_00407	ENOG4105C37	(CBS) domain
HME7025_00409	ENOG4105DA4	cytochrome c-type biogenesis protein
HME7025_00414	ENOG4105CE1	Ferrous iron transport protein b
HME7025_00415	ENOG4105CE1	Ferrous iron transport protein b
HME7025_00418	ENOG41061P3	phosphosulfolactate synthase
HME7025_00419	ENOG4105DQR	SNARE associated Golgi
HME7025_00420	ENOG4105E2X	shikimate dehydrogenase
HME7025_00421	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HME7025_00423	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HME7025_00428	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HME7025_00429	ENOG4108Z6B	deaminase
HME7025_00430	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HME7025_00436	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HME7025_00437	ENOG4107ENK	receptor
HME7025_00438	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HME7025_00443	ENOG4105DF6	Fe-S oxidoreductase
HME7025_00445	ENOG4108ZGC	gaf domain protein
HME7025_00447	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HME7025_00452	ENOG4108ZAF	Molybdopterin
HME7025_00453	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HME7025_00454	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HME7025_00460	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HME7025_00461	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HME7025_00462	ENOG4105CPK	Glycosyl transferase (Group 1
HME7025_00464	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HME7025_00465	ENOG4108UJU	UPF0301 protein
HME7025_00468	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_00469	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HME7025_00473	ENOG4105BZ1	(ABC) transporter
HME7025_00475	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HME7025_00477	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HME7025_00478	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HME7025_00480	ENOG4105CJN	penicillin-binding protein
HME7025_00481	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HME7025_00482	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HME7025_00484	ENOG4105CI2	imidazolone-5-propionate hydrolase
HME7025_00486	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HME7025_00487	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HME7025_00490	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HME7025_00491	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HME7025_00493	ENOG4105DFA	alanine racemase domain protein
HME7025_00495	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
HME7025_00496	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HME7025_00497	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HME7025_00499	ENOG4105CIY	formyltetrahydrofolate deformylase
HME7025_00503	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HME7025_00504	ENOG4107YDW	inorganic pyrophosphatase EC 3.6.1.1
HME7025_00506	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HME7025_00509	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HME7025_00513	ENOG4108NEV	two component transcriptional regulator, LytTR family
HME7025_00518	ENOG4105CPP	Dehydrogenase, E1 component
HME7025_00520	ENOG4105DF2	NADH dehydrogenase subunit j
HME7025_00521	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_00522	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HME7025_00527	ENOG4108JQC	penicillin-binding protein 1A
HME7025_00530	ENOG4105CJN	penicillin-binding protein
HME7025_00531	ENOG4105CNI	cell division protein FtsW
HME7025_00532	ENOG4105CSH	Transporter
HME7025_00535	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HME7025_00536	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HME7025_00537	ENOG4105VHG	atp synthase
HME7025_00538	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HME7025_00540	ENOG4105DWV	Homoserine O-trans-acetylase
HME7025_00541	ENOG4107JEE	Short-chain dehydrogenase reductase Sdr
HME7025_00542	ENOG4105EAA	nucleoside
HME7025_00546	ENOG4105FQP	Beta-lactamase
HME7025_00547	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HME7025_00548	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00555	ENOG4105CSU	acyl-Coa dehydrogenase
HME7025_00560	ENOG410902V	Modulates RecA activity (By similarity)
HME7025_00561	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HME7025_00562	ENOG4105CHR	reductase
HME7025_00563	ENOG4105DNZ	Alpha Beta Hydrolase
HME7025_00564	ENOG4108JQ1	Dehydrogenase
HME7025_00565	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HME7025_00566	ENOG4105EE0	oxidoreductase
HME7025_00570	ENOG4105CDY	transcriptional regulatory protein
HME7025_00573	ENOG4108MGY	Histidine kinase
HME7025_00575	ENOG4107VXZ	Hydrolase
HME7025_00576	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00579	ENOG4108IDZ	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HME7025_00581	ENOG4105EGD	dinuclear metal center protein, YbgI family
HME7025_00582	ENOG4105E09	nadh pyrophosphatase
HME7025_00585	ENOG4105E2R	ROK family
HME7025_00589	ENOG4105KDC	50s ribosomal protein l28
HME7025_00591	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HME7025_00601	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HME7025_00605	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HME7025_00606	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HME7025_00608	ENOG4105DFU	Cell wall formation (By similarity)
HME7025_00609	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HME7025_00611	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HME7025_00612	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HME7025_00613	ENOG4105CE9	30S ribosomal protein S2
HME7025_00614	ENOG4108UJD	30S ribosomal protein S9
HME7025_00615	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HME7025_00616	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HME7025_00618	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HME7025_00619	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HME7025_00620	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HME7025_00621	ENOG4105WXV	50S ribosomal protein L32
HME7025_00624	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HME7025_00625	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HME7025_00626	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HME7025_00627	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HME7025_00630	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HME7025_00632	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HME7025_00633	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HME7025_00634	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HME7025_00637	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HME7025_00638	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HME7025_00639	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HME7025_00642	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_00643	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HME7025_00644	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_00646	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_00651	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HME7025_00652	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_00657	ENOG4105DY9	regulatoR
HME7025_00661	ENOG4105CPK	Glycosyl transferase (Group 1
HME7025_00662	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HME7025_00665	ENOG4107T8Q	Glycosyl transferase (Group 1
HME7025_00666	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HME7025_00669	ENOG4105C1V	Peptidase, M16
HME7025_00670	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HME7025_00671	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HME7025_00672	ENOG41090R7	Ferric uptake
HME7025_00673	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HME7025_00675	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HME7025_00681	ENOG4108IYU	L-aspartate oxidase
HME7025_00682	ENOG4105DBI	uridine monophosphokinase
HME7025_00685	ENOG4108Z0R	Transferase
HME7025_00692	ENOG41083MR	nifu domain-containing protein
HME7025_00697	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HME7025_00698	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HME7025_00700	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HME7025_00701	ENOG4105CUB	amino acid
HME7025_00702	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HME7025_00705	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HME7025_00716	ENOG4107RAQ	aminopeptidase
HME7025_00723	ENOG4107S1E	Beta-lactamase
HME7025_00728	ENOG4107QM2	Aldo Keto reductase
HME7025_00730	ENOG4107VIJ	nudix hydrolase
HME7025_00731	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HME7025_00734	ENOG4105C09	Bile acid
HME7025_00737	ENOG4107TRE	AP endonuclease, family 2
HME7025_00744	ENOG4105C09	Bile acid
HME7025_00745	ENOG4105E2D	ec 3.2.1.52
HME7025_00746	ENOG41061MV	Arylsulfatase
HME7025_00752	ENOG4105E6M	Sulphatase-modifying factor protein
HME7025_00755	ENOG4105D8V	Glucose sorbosone dehydrogenase
HME7025_00760	ENOG4105C3J	Cysteine desulfurase
HME7025_00765	ENOG4105ERG	peptidase m48, ste24p
HME7025_00773	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00781	ENOG4105CBX	hi0933 family
HME7025_00786	ENOG4105CPC	Aldo Keto reductase
HME7025_00787	ENOG4105CPQ	Dehydrogenase
HME7025_00788	ENOG4107S8A	protein TIM barrel
HME7025_00789	ENOG4105QJH	Domain of unknown function (DUF718)
HME7025_00792	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HME7025_00793	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HME7025_00794	ENOG4105EXW	epimerase dehydratase
HME7025_00797	ENOG4107SET	aldo keto reductase
HME7025_00802	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HME7025_00803	ENOG4107QZF	nitrite reductase NADPH large subunit
HME7025_00806	ENOG4107RNU	major facilitator superfamily MFS_1
HME7025_00807	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HME7025_00809	ENOG4105VCQ	rubredoxin
HME7025_00810	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HME7025_00816	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HME7025_00821	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HME7025_00822	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HME7025_00826	ENOG4105EE5	Membrane protein terC
HME7025_00828	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HME7025_00830	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HME7025_00831	ENOG4105C8Y	Acetylornithine aminotransferase
HME7025_00832	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HME7025_00833	ENOG4105CDH	Citrulline--aspartate ligase
HME7025_00835	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HME7025_00837	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HME7025_00844	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HME7025_00850	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HME7025_00851	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HME7025_00854	ENOG4105C1J	atp-dependent rna helicase
HME7025_00855	ENOG4108RMU	ferritin dps family protein
HME7025_00857	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HME7025_00859	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HME7025_00862	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HME7025_00864	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HME7025_00865	ENOG4105D49	3-dehydroquinate synthase
HME7025_00867	ENOG4105CPP	Dehydrogenase, E1 component
HME7025_00868	ENOG4105C0H	protease
HME7025_00869	ENOG4105CRK	lysyL-tRNA synthetase
HME7025_00870	ENOG4105VEQ	Cold shock protein
HME7025_00873	ENOG4105CUB	amino acid
HME7025_00875	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HME7025_00877	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HME7025_00879	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HME7025_00881	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HME7025_00885	ENOG4105DHJ	ABC, transporter
HME7025_00886	ENOG4107R0I	Cell wall formation (By similarity)
HME7025_00890	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HME7025_00892	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HME7025_00893	ENOG4105DKQ	ROK family
HME7025_00895	ENOG4107T8J	thymidine kinase
HME7025_00902	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HME7025_00906	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_00908	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HME7025_00916	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HME7025_00917	ENOG4105KVH	Transcriptional regulator
HME7025_00918	ENOG4107QKV	phosphomannomutase
HME7025_00919	ENOG4107QI6	Cysteine desulfurase
HME7025_00920	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HME7025_00923	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HME7025_00926	ENOG4105EEI	dihydropteroate synthase
HME7025_00927	ENOG4105F0I	Aminotransferase
HME7025_00928	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HME7025_00929	ENOG4105CUZ	uba thif-type nad fad binding protein
HME7025_00931	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HME7025_00932	ENOG4108B1Q	Ribonuclease
HME7025_00933	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HME7025_00934	ENOG4105C5R	Aminotransferase
HME7025_00935	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HME7025_00936	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HME7025_00939	ENOG4105K8N	protein family UPF0079, ATPase
HME7025_00945	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HME7025_00946	ENOG4105CNU	cell division protein FtsK
HME7025_00948	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HME7025_00951	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HME7025_00954	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HME7025_00956	ENOG410635A	Membrane
HME7025_00957	ENOG4105C8T	Leucyl-tRNA synthetase
HME7025_00958	ENOG41061MV	Arylsulfatase
HME7025_00961	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HME7025_00966	ENOG4105D49	3-dehydroquinate synthase
HME7025_00971	ENOG4105CCT	upf0313 protein
HME7025_00972	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HME7025_00977	ENOG4105CGY	Dna recombination protein
HME7025_00983	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HME7025_00984	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HME7025_00986	ENOG4108WBT	adenosyltransferase
HME7025_00987	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HME7025_00990	ENOG4108IQE	Amp-dependent synthetase and ligase
HME7025_00991	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HME7025_00992	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HME7025_00993	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HME7025_00994	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HME7025_00995	ENOG4108HKT	sucrose-6-phosphate hydrolase
HME7025_00999	ENOG4108IUX	(ABC) transporter
HME7025_01000	ENOG4105RHA	ABC transporter, permease
HME7025_01002	ENOG4105EN6	Membrane
HME7025_01004	ENOG4105KUZ	arsenate reductase
HME7025_01005	ENOG4105C9Q	fumarate hydratase class II
HME7025_01007	ENOG41082BM	Transcriptional regulator, arsr family
HME7025_01008	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HME7025_01009	ENOG4105BZA	Phosphoglycerate kinase
HME7025_01012	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HME7025_01014	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HME7025_01018	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HME7025_01019	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HME7025_01026	ENOG4105BZM	domain protein
HME7025_01028	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HME7025_01029	ENOG4105C0B	DNA polymerase III (alpha subunit)
HME7025_01034	ENOG4108RAV	Conserved protein
HME7025_01037	ENOG4105E0X	reductase
HME7025_01038	ENOG4105C3M	thioredoxin reductase
HME7025_01039	ENOG4105K63	Thioredoxin
HME7025_01041	ENOG4105FQ6	thiopurine methyltransferase
HME7025_01044	ENOG4105NQN	cytochrome C
HME7025_01052	ENOG4105C72	UPF0176 protein
HME7025_01053	ENOG4107TPS	domain protein
HME7025_01054	ENOG4108VCT	Sulfite exporter TauE/SafE
HME7025_01057	ENOG4105D9R	oxidoreductase
HME7025_01059	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HME7025_01064	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HME7025_01065	ENOG4105DKW	ABC transporter
HME7025_01066	ENOG4105DC7	peptidase M24
HME7025_01067	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_01068	ENOG4105TT1	Ragb susd domain-containing protein
HME7025_01076	ENOG4105C2J	ABC transporter
HME7025_01077	ENOG4105CNN	ABC, transporter
HME7025_01078	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HME7025_01082	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HME7025_01088	ENOG4107QJZ	Glycosyl transferase, family 2
HME7025_01090	ENOG4105BZU	Histidine kinase
HME7025_01091	ENOG4105BZU	Histidine kinase
HME7025_01097	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HME7025_01098	ENOG4105XA0	heptosyltransferase ii
HME7025_01101	ENOG4105C2M	dna polymerase I
HME7025_01102	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HME7025_01106	ENOG4105DR5	peptidase
HME7025_01107	ENOG4105C3M	thioredoxin reductase
HME7025_01108	ENOG4107QJT	sodium dicarboxylate symporter
HME7025_01109	ENOG4105C6K	Malic enzyme
HME7025_01112	ENOG4105EHZ	conserved protein UCP016719
HME7025_01113	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HME7025_01114	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HME7025_01116	ENOG4105K6T	rare lipoprotein A
HME7025_01117	ENOG4105UYK	outer membrane protein a
HME7025_01118	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HME7025_01121	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HME7025_01124	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HME7025_01125	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HME7025_01126	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HME7025_01127	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HME7025_01130	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HME7025_01133	ENOG4105X54	addiction module antidote protein
HME7025_01137	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HME7025_01138	ENOG4105DCG	PHP domain protein
HME7025_01139	ENOG4108URH	decarboxylase
HME7025_01140	ENOG4108YZG	isomerase
HME7025_01142	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HME7025_01143	ENOG4105D60	lipoprotein releasing system transmembrane protein
HME7025_01151	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HME7025_01152	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HME7025_01153	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HME7025_01154	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HME7025_01156	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HME7025_01158	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HME7025_01159	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HME7025_01160	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HME7025_01167	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HME7025_01169	ENOG4108JQC	penicillin-binding protein 1A
HME7025_01170	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HME7025_01173	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HME7025_01175	ENOG41090HT	Inherit from COG: transposase
HME7025_01178	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HME7025_01180	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HME7025_01196	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HME7025_01200	ENOG4108YZA	Nitrogen regulatory protein pii
HME7025_01202	ENOG4105E2D	ec 3.2.1.52
HME7025_01205	ENOG4105F5H	Glycosyl Hydrolase Family 88
HME7025_01206	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HME7025_01208	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HME7025_01213	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
HME7025_01223	ENOG4105EW9	transcriptional regulator AsnC family
HME7025_01225	ENOG4105DCF	alanine dehydrogenase
HME7025_01227	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HME7025_01228	ENOG4105CW7	secretion protein, HlyD family
HME7025_01233	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HME7025_01235	ENOG4105C79	DNA protecting protein DprA
HME7025_01236	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HME7025_01238	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HME7025_01240	ENOG4105C5H	ABC transporter
HME7025_01241	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_01242	ENOG4105C26	Dehydrogenase
HME7025_01246	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HME7025_01247	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HME7025_01248	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HME7025_01250	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HME7025_01251	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HME7025_01256	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HME7025_01257	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HME7025_01259	ENOG4105DUX	Transporter
HME7025_01260	ENOG4107QJE	Chromosome Partitioning Protein
HME7025_01261	ENOG4105FA0	parb-like partition protein
HME7025_01263	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HME7025_01265	ENOG4105C3F	Signal peptidase i
HME7025_01266	ENOG4105DR4	Methyltransferase
HME7025_01268	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
HME7025_01269	ENOG4105W5Q	DNA repair protein (RadC
HME7025_01271	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HME7025_01273	ENOG4105C1J	atp-dependent rna helicase
HME7025_01276	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HME7025_01278	ENOG4105CQB	FAD linked oxidase domain protein
HME7025_01279	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HME7025_01280	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HME7025_01283	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HME7025_01285	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HME7025_01288	ENOG4105CD3	dihydroorotase
HME7025_01292	ENOG4105CZV	ABC transporter
HME7025_01293	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HME7025_01294	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HME7025_01295	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HME7025_01296	ENOG4105DCI	Phosphohydrolase
HME7025_01300	ENOG4105QE3	oxidoreductase
HME7025_01301	ENOG4105DZG	Dehydrogenase
HME7025_01302	ENOG4107YRA	Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity)
HME7025_01304	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HME7025_01305	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HME7025_01306	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HME7025_01307	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HME7025_01309	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HME7025_01310	ENOG4105CN9	Peptidase m42 family protein
HME7025_01311	ENOG4105CTQ	phosphohexokinase
HME7025_01312	ENOG41080C8	DUF218 domain
HME7025_01317	ENOG4105C3G	gtp-binding protein
HME7025_01319	ENOG4105C5H	ABC transporter
HME7025_01320	ENOG4105CBC	glutamate synthase
HME7025_01321	ENOG4105DG4	malate L-lactate dehydrogenase
HME7025_01322	ENOG4105HHA	aminodeoxychorismate lyase
HME7025_01325	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HME7025_01329	ENOG4105CHR	reductase
HME7025_01332	ENOG4105K5M	30s ribosomal protein S16
HME7025_01333	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HME7025_01334	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HME7025_01335	ENOG4107RT3	EamA-like transporter family
HME7025_01337	ENOG4107R7I	amino acid
HME7025_01339	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_01342	ENOG4105CY0	Metallo-Beta-Lactamase
HME7025_01343	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HME7025_01344	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
HME7025_01345	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HME7025_01346	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HME7025_01348	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HME7025_01349	ENOG4107XZA	Glycosyl transferase family 2
HME7025_01350	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HME7025_01351	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HME7025_01352	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HME7025_01359	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HME7025_01360	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HME7025_01361	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HME7025_01363	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HME7025_01364	ENOG4107RAQ	aminopeptidase
HME7025_01365	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HME7025_01368	ENOG4105CUT	histidyl-tRNA synthetase
HME7025_01369	ENOG4107QP8	phosphohexose isomerase
HME7025_01371	ENOG4105D3R	alkyl hydroperoxide reductase
HME7025_01375	ENOG4105C34	Pseudouridine synthase
HME7025_01376	ENOG4105KY5	gCN5-related N-acetyltransferase
HME7025_01379	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
HME7025_01380	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HME7025_01381	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HME7025_01385	ENOG4107WT5	transcriptional regulator (NifA
HME7025_01386	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HME7025_01387	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HME7025_01388	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HME7025_01389	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HME7025_01390	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HME7025_01391	ENOG4108HHA	Transketolase
HME7025_01392	ENOG4108IUS	Transketolase
HME7025_01394	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HME7025_01396	ENOG4105CHM	Aminotransferase
HME7025_01399	ENOG4107QWK	SAICAR synthetase
HME7025_01407	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HME7025_01408	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HME7025_01410	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
HME7025_01411	ENOG4105ESV	Glycosyl transferase, family 4
HME7025_01412	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HME7025_01413	ENOG4105CQC	Prephenate dehydratase
HME7025_01414	ENOG4105DTN	riboflavin biosynthesis protein ribF
HME7025_01415	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HME7025_01416	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HME7025_01418	ENOG4107RJ9	Cell division protein FtsX
HME7025_01420	ENOG4105C10	Electron transfer flavoprotein
HME7025_01421	ENOG4105BZJ	Electron transfer flavoprotein
HME7025_01423	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HME7025_01427	ENOG4105EY8	ABC transporter
HME7025_01431	ENOG4107RBB	ABC transporter, permease
HME7025_01433	ENOG4105CMG	Carbohydrate kinase
HME7025_01435	ENOG4105F8V	Hydrolase, tatD family
HME7025_01436	ENOG4108ZJ4	polysaccharide deacetylase
HME7025_01437	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HME7025_01438	ENOG4105C7Z	Conserved Protein
HME7025_01439	ENOG4105DZ0	fad dependent oxidoreductase
HME7025_01441	ENOG4105DF5	DNA topoisomerase IV, subunit A
HME7025_01443	ENOG4105C5Q	Transcriptional regulator
HME7025_01445	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HME7025_01447	ENOG4105CKK	Glycosyl transferase, family 2
HME7025_01448	ENOG4105EXC	Acyl-transferase
HME7025_01449	ENOG4105UYK	outer membrane protein a
HME7025_01450	ENOG4105DJV	ribulose-phosphate 3-epimerase
HME7025_01451	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HME7025_01452	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HME7025_01457	ENOG4105EDR	glucose galactose transporter
HME7025_01459	ENOG4105CTX	dehydratase
HME7025_01460	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HME7025_01464	ENOG4105CHR	reductase
HME7025_01467	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HME7025_01468	ENOG4105C01	Dihydroxy-acid dehydratase
HME7025_01470	ENOG4105C87	Aminotransferase class I and II
HME7025_01473	ENOG4107URF	beta-phospho-glucomutase
HME7025_01476	ENOG4105CFG	Acts as a chaperone (By similarity)
HME7025_01477	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
HME7025_01479	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HME7025_01480	ENOG4105VJV	50s ribosomal protein L35
HME7025_01481	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HME7025_01482	ENOG4105C22	threonyL-tRNA synthetase
HME7025_01489	ENOG4108IPT	Naphthoate synthase
HME7025_01492	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HME7025_01493	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HME7025_01496	ENOG4108I0Z	Aconitate hydratase
HME7025_01497	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HME7025_01498	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HME7025_01499	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HME7025_01501	ENOG4105C8Y	Acetylornithine aminotransferase
HME7025_01502	ENOG4105K63	Thioredoxin
HME7025_01503	ENOG4105C0B	DNA polymerase III (alpha subunit)
HME7025_01505	ENOG4105C31	Tryptophanyl-tRNA synthetase
HME7025_01508	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HME7025_01510	ENOG4105BZU	Histidine kinase
HME7025_01511	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HME7025_01512	ENOG4107R5B	glutamine synthetase
HME7025_01515	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HME7025_01518	ENOG4105C7S	Dehydrogenase
HME7025_01519	ENOG4105CEV	competence damage-inducible protein
HME7025_01522	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HME7025_01524	ENOG4105EPC	oxidoreductase
HME7025_01525	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HME7025_01526	ENOG4105EUJ	GTP cyclohydrolase i
HME7025_01527	ENOG4105CHR	reductase
HME7025_01529	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HME7025_01530	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HME7025_01534	ENOG4105ED2	Beta-lactamase
HME7025_01535	ENOG4105C72	UPF0176 protein
HME7025_01538	ENOG4105EUB	pirin domain protein
HME7025_01539	ENOG41082BV	acetyltransferase
HME7025_01540	ENOG4105C9A	Phoh family
HME7025_01541	ENOG4105CDU	Replicative dna helicase
HME7025_01541	ENOG4105CDU	Replicative dna helicase
HME7025_01542	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HME7025_01547	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HME7025_01549	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HME7025_01553	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HME7025_01555	ENOG4105BZU	Histidine kinase
HME7025_01559	ENOG4105CHH	sulfate transporter
HME7025_01560	ENOG4105EVH	UPF0753 protein
HME7025_01561	ENOG4105D65	subunit l
HME7025_01563	ENOG4105CK5	oxidoreductase
HME7025_01566	ENOG4107SQI	penicillin amidase
HME7025_01567	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HME7025_01570	ENOG4105CHR	reductase
HME7025_01571	ENOG4105CPQ	Dehydrogenase
HME7025_01574	ENOG4105E0M	Sulfatase
HME7025_01580	ENOG4105D2S	major facilitator superfamily
HME7025_01581	ENOG4105CPQ	Dehydrogenase
HME7025_01583	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HME7025_01588	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HME7025_01592	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HME7025_01593	ENOG4107YWA	deoxycytidylate deaminase
HME7025_01598	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HME7025_01599	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HME7025_01600	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HME7025_01601	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HME7025_01603	ENOG4108ZCU	PPIases accelerate the folding of proteins
HME7025_01610	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HME7025_01611	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HME7025_01612	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HME7025_01613	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HME7025_01614	ENOG4105QNR	S1 RNA binding domain protein
HME7025_01618	ENOG4105GR3	Histidine kinase
HME7025_01624	ENOG4105ETE	Transcriptional regulator (LacI family
HME7025_01625	ENOG4105KRF	dihydroneopterin aldolase
HME7025_01629	ENOG41063JG	Transcriptional regulator
HME7025_01630	ENOG4105CMR	udp-glucose 4-epimerase
HME7025_01631	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HME7025_01635	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HME7025_01636	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HME7025_01638	ENOG4107RJ1	sodium solute
HME7025_01639	ENOG4108YYC	ycei family
HME7025_01651	ENOG4105KWG	Pfam:DUF1696
HME7025_01655	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HME7025_01657	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HME7025_01658	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HME7025_01659	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HME7025_01660	ENOG4105CXT	aspartate transcarbamylase
HME7025_01662	ENOG4105C1V	Peptidase, M16
HME7025_01663	ENOG4105CSA	Coproporphyrinogen iii oxidase
HME7025_01664	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HME7025_01665	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HME7025_01667	ENOG4107X35	defense response to bacterium
HME7025_01669	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HME7025_01673	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HME7025_01674	ENOG4105EMU	Dehydrogenase
HME7025_01675	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HME7025_01677	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HME7025_01678	ENOG41083X6	30S ribosomal protein S21
HME7025_01679	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HME7025_01680	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HME7025_01681	ENOG4105CFH	Aspartokinase
HME7025_01682	ENOG4105H67	Protein of unknown function (DUF421)
HME7025_01683	ENOG4109015	Biopolymer transport protein exbD tolR
HME7025_01685	ENOG4105D49	3-dehydroquinate synthase
HME7025_01687	ENOG4105C1V	Peptidase, M16
HME7025_01688	ENOG4108Y6J	UPF0403 protein
HME7025_01689	ENOG4105VG1	fes assembly suf system protein
HME7025_01690	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HME7025_01691	ENOG4105C9B	Cysteine desulfurase
HME7025_01692	ENOG4105JRK	feS assembly protein SufD
HME7025_01693	ENOG4105C3K	feS assembly ATPase SufC
HME7025_01694	ENOG4108Z4V	iron-sulfur cluster assembly
HME7025_01697	ENOG4108YYC	ycei family
HME7025_01698	ENOG4108RCM	Nitroreductase
HME7025_01699	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HME7025_01700	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HME7025_01701	ENOG4105C75	arginyL-tRNA synthetase
HME7025_01702	ENOG4108V06	Glutathione peroxidase
HME7025_01703	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HME7025_01708	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HME7025_01709	ENOG4105CMR	udp-glucose 4-epimerase
HME7025_01710	ENOG4108KPZ	tonB-dependent Receptor
HME7025_01711	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HME7025_01712	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HME7025_01714	ENOG4105C5X	domain protein
HME7025_01715	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HME7025_01719	ENOG4105SYT	Methylenetetrahydrofolate reductase
HME7025_01720	ENOG4105C3R	Methionine synthase
HME7025_01721	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HME7025_01727	ENOG4107R33	ppx gppa phosphatase
HME7025_01729	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HME7025_01730	ENOG4105CAK	Cell division ATP-binding protein ftsE
HME7025_01731	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HME7025_01739	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HME7025_01740	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HME7025_01741	ENOG4108JQ1	Dehydrogenase
HME7025_01743	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HME7025_01745	ENOG4105DSJ	YicC domain protein
HME7025_01748	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HME7025_01751	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HME7025_01752	ENOG4105C28	cystathionine
HME7025_01756	ENOG41082J7	Rhodanese domain protein
HME7025_01766	ENOG4106A4F	Removes the N-terminal methionine from nascent proteins (By similarity)
HME7025_01769	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HME7025_01772	ENOG4105F23	Fibronectin-binding protein
HME7025_01773	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HME7025_01774	ENOG4105ERH	Fumarylacetoacetate hydrolase
HME7025_01776	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HME7025_01778	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HME7025_01779	ENOG4105BZU	Histidine kinase
HME7025_01780	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HME7025_01781	ENOG4105CJW	magnesium transporter
HME7025_01782	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HME7025_01783	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
HME7025_01784	ENOG4105C5I	Dehydrogenase
HME7025_01786	ENOG4105C6Z	Gluconate
HME7025_01796	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HME7025_01797	ENOG4105CE4	GlcNAc 6-P deacetylase
HME7025_01801	ENOG4107ZSV	Receptor
HME7025_01803	ENOG4105D05	Receptor
HME7025_01816	ENOG4105BZU	Histidine kinase
HME7025_01821	ENOG4105BZU	Histidine kinase
HME7025_01823	ENOG4108UKI	Enoyl-CoA hydratase
HME7025_01825	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HME7025_01826	ENOG4105C5S	asparaginyl-tRNA synthetase
HME7025_01827	ENOG4107YR5	Diacylglycerol kinase
HME7025_01829	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HME7025_01830	ENOG4107QI1	Mate efflux family protein
HME7025_01833	ENOG4107QN2	dihydrolipoyl dehydrogenase
HME7025_01834	ENOG4105C7S	Dehydrogenase
HME7025_01835	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HME7025_01838	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HME7025_01841	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HME7025_01842	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
HME7025_01847	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HME7025_01848	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HME7025_01852	ENOG4105BZ1	(ABC) transporter
HME7025_01855	ENOG4105CN1	protease
HME7025_01857	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HME7025_01858	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HME7025_01860	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HME7025_01863	ENOG4105C59	p-type ATPase
HME7025_01871	ENOG4107QP7	CoA-transferase subunit A
HME7025_01872	ENOG4107R55	ethanolamine transporter
HME7025_01874	ENOG4105C0A	alcohol dehydrogenase
HME7025_01876	ENOG4105C26	Dehydrogenase
HME7025_01878	ENOG4105DQ4	alcohol dehydrogenase
HME7025_01881	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HME7025_01882	ENOG4105MEV	Acyl-transferase
HME7025_01883	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HME7025_01886	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_01887	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HME7025_01888	ENOG4107QR9	Iron-sulfur cluster binding protein
HME7025_01889	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HME7025_01891	ENOG4105C9F	isomerase
HME7025_01893	ENOG4105CH2	amidohydrolase
HME7025_01895	ENOG4105D1H	recombination factor protein RarA
HME7025_01897	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HME7025_01899	ENOG4105DTQ	mandelate racemase muconate lactonizing
HME7025_01901	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HME7025_01909	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HME7025_01910	ENOG41082BM	Transcriptional regulator, arsr family
HME7025_01914	ENOG4105QVC	MOSC domain-containing protein
HME7025_01916	ENOG4105BZ1	(ABC) transporter
HME7025_01917	ENOG4107R6T	Involved in the transcription termination process (By similarity)
HME7025_01920	ENOG4105VIE	preprotein translocase, subunit YajC
HME7025_01922	ENOG4105C6E	dna polymerase iii
HME7025_01928	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HME7025_01931	ENOG4105CAT	Cytidine monophosphate kinase
HME7025_01932	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HME7025_01934	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HME7025_01936	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HME7025_01939	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HME7025_01941	ENOG4107R5Z	Oxidoreductase domain protein
HME7025_01942	ENOG4105CIB	oxidoreductase Domain protein
HME7025_01944	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HME7025_01945	ENOG4105D9N	nucleoside
HME7025_01946	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HME7025_01948	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HME7025_01949	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HME7025_01950	ENOG4105EP8	Glycosyl Hydrolase Family 88
HME7025_01951	ENOG4105CHR	reductase
HME7025_01954	ENOG4108MCI	Transcriptional regulator, ARAC family
HME7025_01964	ENOG4107GJV	short-chain dehydrogenase reductase
HME7025_01965	ENOG4105CT4	transporter
HME7025_01967	ENOG4107QW3	Sucrose phosphorylase
HME7025_01970	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HME7025_01971	ENOG4105C9K	Endothelin-converting enzyme 1
HME7025_01973	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_01975	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_01976	ENOG4105C6Z	Gluconate
HME7025_01982	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HME7025_01985	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HME7025_01986	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HME7025_01989	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HME7025_01998	ENOG4105KNE	Phosphatidate cytidylyltransferase
HME7025_02001	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HME7025_02006	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HME7025_02007	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HME7025_02011	ENOG4105KNA	-acetyltransferase
HME7025_02012	ENOG4107REN	Carbamoyltransferase
HME7025_02013	ENOG4107T6X	nag kinase
HME7025_02014	ENOG4105CWC	Acetylornithine deacetylase
HME7025_02015	ENOG4105CH7	arginosuccinase
HME7025_02016	ENOG4108R6K	riboflavin synthase, subunit alpha
HME7025_02021	ENOG4105BZU	Histidine kinase
HME7025_02023	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HME7025_02028	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HME7025_02029	ENOG4105CQB	FAD linked oxidase domain protein
HME7025_02031	ENOG4105CKK	Glycosyl transferase, family 2
HME7025_02033	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HME7025_02034	ENOG4105NRA	50s ribosomal protein l31 type b
HME7025_02035	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HME7025_02036	ENOG4107QRG	dna polymerase iii
HME7025_02037	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HME7025_02038	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HME7025_02039	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HME7025_02040	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HME7025_02041	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_02043	ENOG4108MR6	WD40-like Beta Propeller Repeat
HME7025_02045	ENOG4105C25	Primosomal protein n'
HME7025_02053	ENOG4105E6M	Sulphatase-modifying factor protein
HME7025_02058	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HME7025_02060	ENOG4108KF3	Electron transport protein SCO1 SenC
HME7025_02064	ENOG4105D64	Mechanosensitive ion channel
HME7025_02065	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HME7025_02066	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HME7025_02068	ENOG4105C7K	acetolactate synthase
HME7025_02069	ENOG4105C01	Dihydroxy-acid dehydratase
HME7025_02070	ENOG4108JJ7	ABC transporter
HME7025_02071	ENOG4105D5U	fad dependent oxidoreductase
HME7025_02072	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HME7025_02073	ENOG4105EI2	Pseudouridine synthase
HME7025_02075	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HME7025_02085	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HME7025_02088	ENOG4105E3B	Multicopper oxidase
HME7025_02101	ENOG4105I82	acetyl xylan esterase
HME7025_02104	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HME7025_02106	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
HME7025_02117	ENOG4105D05	Receptor
HME7025_02121	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_02126	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HME7025_02128	ENOG4105CPQ	Dehydrogenase
HME7025_02129	ENOG4105CJ1	ABC, transporter
HME7025_02133	ENOG4105UNS	Pfam:DUF419
HME7025_02136	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HME7025_02137	ENOG4105HCZ	
HME7025_02139	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HME7025_02141	ENOG4105CHU	acetyl-coa acetyltransferase
HME7025_02142	ENOG4105C8Y	Acetylornithine aminotransferase
HME7025_02143	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HME7025_02144	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HME7025_02145	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HME7025_02146	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HME7025_02151	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HME7025_02154	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_02155	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HME7025_02160	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HME7025_02161	ENOG4105CHV	Transcription elongation factor NusA
HME7025_02162	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
HME7025_02163	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HME7025_02165	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HME7025_02166	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HME7025_02167	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HME7025_02169	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HME7025_02177	ENOG4105C93	Xylose Isomerase
HME7025_02181	ENOG4105EMN	RNA polymerase sigma factor
HME7025_02188	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HME7025_02189	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HME7025_02190	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HME7025_02192	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HME7025_02193	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HME7025_02195	ENOG4108AEY	RNA polymerase sigma factor
HME7025_02197	ENOG4105CSM	endonuclease III
HME7025_02198	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HME7025_02199	ENOG4105SCY	DNAK suppressor
HME7025_02202	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HME7025_02203	ENOG4107QN2	dihydrolipoyl dehydrogenase
HME7025_02210	ENOG4105EB3	Histidine kinase
HME7025_02214	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HME7025_02215	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HME7025_02216	ENOG4108176	endoribonuclease L-psp
HME7025_02217	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HME7025_02218	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HME7025_02220	ENOG4105D65	subunit l
HME7025_02225	ENOG4105CHR	reductase
HME7025_02229	ENOG41067XB	TonB family
HME7025_02237	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HME7025_02238	ENOG4105C0P	Mg chelatase subunit ChlI
HME7025_02241	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HME7025_02244	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HME7025_02246	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HME7025_02247	ENOG4105CFH	Aspartokinase
HME7025_02248	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HME7025_02252	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HME7025_02253	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HME7025_02254	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HME7025_02257	ENOG4105DFU	Cell wall formation (By similarity)
HME7025_02259	ENOG4105C5H	ABC transporter
HME7025_02261	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HME7025_02262	ENOG4107TDE	lipolytic protein G-D-S-L family
HME7025_02268	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HME7025_02270	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HME7025_02271	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
HME7025_02274	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HME7025_02275	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HME7025_02278	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HME7025_02280	ENOG4105BZ1	(ABC) transporter
HME7025_02291	ENOG4105DR9	pseudouridine synthase
HME7025_02293	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HME7025_02294	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HME7025_02295	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HME7025_02297	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HME7025_02298	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HME7025_02300	ENOG4105DZP	Membrane-associated zinc metalloprotease
HME7025_02301	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HME7025_02304	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_02305	ENOG41083ND	50S ribosomal protein L33
HME7025_02307	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HME7025_02311	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HME7025_02312	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HME7025_02315	ENOG4106VK6	Flagellar motor protein
HME7025_02316	ENOG4105C1G	acyl-Coa dehydrogenase
HME7025_02319	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HME7025_02320	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HME7025_02322	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HME7025_02324	ENOG4105VG0	50S ribosomal protein l34
HME7025_02325	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HME7025_02326	ENOG4105CN1	protease
HME7025_02327	ENOG41072GX	Peptidase M22 Glycoprotease
HME7025_02332	ENOG4107RAJ	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HME7025_02335	ENOG4105CGK	Exodeoxyribonuclease III
HME7025_02339	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HME7025_02340	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_02342	ENOG4105C8S	subunit m
HME7025_02343	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HME7025_02352	ENOG4105C8N	cysteinyl-tRNA synthetase
HME7025_02355	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HME7025_02356	ENOG4105CI3	gtp-binding protein typa
HME7025_02357	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HME7025_02358	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HME7025_02359	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HME7025_02361	ENOG4105EMN	RNA polymerase sigma factor
HME7025_02364	ENOG4105DFF	Rod shape-determining protein mreb
HME7025_02366	ENOG4105FE9	pseudouridine synthase
HME7025_02367	ENOG4105UYK	outer membrane protein a
HME7025_02368	ENOG4105CD3	dihydroorotase
HME7025_02370	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HME7025_02372	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HME7025_02374	ENOG4105C30	Nad-dependent epimerase dehydratase
HME7025_02377	ENOG4105CHH	sulfate transporter
HME7025_02378	ENOG41077A9	carbonic anhydrase
HME7025_02379	ENOG4105C9M	aspartyl-trna synthetase
HME7025_02382	ENOG4105C2X	Arabinose 5-phosphate isomerase
HME7025_02383	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HME7025_02384	ENOG4105C12	Phosphoribosylglycinamide synthetase
HME7025_02385	ENOG4105MA4	psp1 domain protein
HME7025_02387	ENOG4105EW9	transcriptional regulator AsnC family
HME7025_02388	ENOG4105Y49	secretion protein, HlyD family
HME7025_02390	ENOG4105BZS	acriflavin resistance protein
HME7025_02391	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HME7025_02395	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HME7025_02397	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HME7025_02403	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HME7025_02408	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HME7025_02409	ENOG4108ZT0	50S ribosomal protein l17
HME7025_02410	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HME7025_02411	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HME7025_02412	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HME7025_02413	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HME7025_02414	ENOG410864M	50S ribosomal protein L36
HME7025_02415	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HME7025_02416	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HME7025_02417	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HME7025_02418	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HME7025_02419	ENOG41084HK	50S ribosomal protein L30
HME7025_02420	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HME7025_02421	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HME7025_02422	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HME7025_02423	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HME7025_02424	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HME7025_02425	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HME7025_02426	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HME7025_02427	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HME7025_02428	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HME7025_02429	ENOG4108628	50s ribosomal protein l29
HME7025_02430	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HME7025_02431	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HME7025_02432	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HME7025_02433	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HME7025_02434	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HME7025_02435	ENOG41081DX	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HME7025_02436	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HME7025_02437	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HME7025_02438	ENOG4105D2N	Aldolase
HME7025_02440	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HME7025_02441	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HME7025_02442	ENOG4105KTH	gatB Yqey
HME7025_02444	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HME7025_02448	ENOG4107QVM	von Willebrand factor, type A
HME7025_02449	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HME7025_02453	ENOG4105DQR	SNARE associated Golgi
HME7025_02454	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HME7025_02456	ENOG41074B2	UPF0747 protein
HME7025_02457	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
HME7025_02458	ENOG4105D7W	serine acetyltransferase
HME7025_02459	ENOG4105C6T	cysteine synthase
HME7025_02462	ENOG4105CI2	imidazolone-5-propionate hydrolase
HME7025_02463	ENOG4105CI2	imidazolone-5-propionate hydrolase
HME7025_02468	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HME7025_02472	ENOG4108IUZ	ABC transporter
HME7025_02473	ENOG4105C28	cystathionine
HME7025_02476	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HME7025_02480	ENOG4105DMT	epimerase dehydratase
HME7025_02483	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HME7025_02484	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_02485	ENOG4105CAQ	asparagine synthetase
HME7025_02486	ENOG4107RA4	Glycosyl transferase (Group 1
HME7025_02487	ENOG4105CAQ	asparagine synthetase
HME7025_02489	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HME7025_02490	ENOG4105CG5	Glycosyl transferase (Group 1
HME7025_02493	ENOG4108UW5	maltose o-acetyltransferase
HME7025_02496	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HME7025_02497	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HME7025_02498	ENOG4105D2T	synthase
HME7025_02499	ENOG4105D2T	synthase
HME7025_02500	ENOG4108JU4	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HME7025_02502	ENOG4105I2C	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HME7025_02505	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HME7025_02506	ENOG4107TY6	Acylneuraminate cytidylyltransferase
HME7025_02509	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HME7025_02510	ENOG4105C5E	polysaccharide biosynthesis protein
HME7025_02512	ENOG4107QQG	Dehydrogenase
HME7025_02514	ENOG4105D3Q	Sugar transferase
HME7025_02515	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HME7025_02525	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_02530	ENOG4105C2I	pirin domain protein
HME7025_02531	ENOG4108YYC	ycei family
HME7025_02543	ENOG4105CBG	Sulfatase
HME7025_02545	ENOG4105CNT	hydrolase family 2
HME7025_02548	ENOG4106HBN	Galactosamine-6-phosphate isomerase
HME7025_02552	ENOG4105EUB	pirin domain protein
HME7025_02554	ENOG4105C27	TonB-dependent Receptor Plug
HME7025_02570	ENOG4105DPW	Major facilitator superfamily MFS_1
HME7025_02571	ENOG4105CHR	reductase
HME7025_02572	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HME7025_02573	ENOG4108M60	Transcriptional regulator
HME7025_02576	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HME7025_02579	ENOG4105D63	family UPF0324
HME7025_02590	ENOG4105DZG	Dehydrogenase
HME7025_02600	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HME7025_02602	ENOG41067XB	TonB family
HME7025_02604	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HME7025_02606	ENOG4108Z9K	Osmotically inducible protein
HME7025_02612	ENOG4105EBR	Carboxylesterase
HME7025_02613	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HME7025_02619	ENOG4105C2C	drug resistance transporter, Bcr CflA
HME7025_02621	ENOG4105BZ1	(ABC) transporter
HME7025_02624	ENOG4105VMP	Transcriptional regulator
HME7025_02641	ENOG4105DYC	esterase
HME7025_02655	ENOG4105KVH	Transcriptional regulator
HME7025_02662	ENOG4105CEY	Amp-dependent synthetase and ligase
HME7025_02666	ENOG4105DUM	transcriptional regulator, lysR family
HME7025_02668	ENOG4105EPC	oxidoreductase
HME7025_02669	ENOG4108MR6	WD40-like Beta Propeller Repeat