locus-tag	class	description
GIY23_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GIY23_00010	COG0592	DNA-directed DNA polymerase activity
GIY23_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GIY23_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GIY23_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GIY23_00030	COG0187	DNA topoisomerase II activity
GIY23_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GIY23_00035	COG1372	Participates in initiation and elongation during chromosome replication
GIY23_00065	COG2124	cytochrome p450
GIY23_00080	COG2814	Major facilitator Superfamily
GIY23_00090	COG2814	Major facilitator Superfamily
GIY23_00110	COG0705	Rhomboid family
GIY23_00110	COG0457	Tetratricopeptide repeat
GIY23_00130	COG0515	serine threonine protein kinase
GIY23_00130	COG2815	serine threonine protein kinase
GIY23_00135	COG0515	serine threonine protein kinase
GIY23_00140	COG0768	penicillin binding
GIY23_00155	COG1716	ATPase activity
GIY23_00160	COG1716	ATPase activity
GIY23_00170	COG0640	Transcriptional regulator
GIY23_00175	COG0346	lactoylglutathione lyase activity
GIY23_00180	COG1819	glycosyl
GIY23_00200	COG0702	epimerase
GIY23_00215	COG1414	Transcriptional regulator
GIY23_00240	COG1309	transcriptional regulator
GIY23_00290	COG1174	glycine betaine transport
GIY23_00300	COG1174	glycine betaine transport
GIY23_00310	COG0405	Gamma-glutamyltransferase
GIY23_00315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GIY23_00320	COG0667	Aldo Keto reductase
GIY23_00340	COG1929	Belongs to the glycerate kinase type-1 family
GIY23_00365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIY23_00405	COG1473	amidohydrolase
GIY23_00410	COG0477	Major facilitator Superfamily
GIY23_00415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GIY23_00445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GIY23_00450	COG3275	phosphorelay sensor kinase activity
GIY23_00470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIY23_00480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIY23_00505	COG2124	cytochrome p450
GIY23_00510	COG0653	protein targeting
GIY23_00515	COG1191	sigma factor activity
GIY23_00520	COG1528	Iron-storage protein
GIY23_00535	COG2235	arginine
GIY23_00580	COG1271	oxidase subunit
GIY23_00585	COG1294	oxidase, subunit
GIY23_00590	COG4988	ABC transporter
GIY23_00610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GIY23_00640	COG0754	glutathionylspermidine amidase activity
GIY23_00645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GIY23_00660	COG0561	phosphatase activity
GIY23_00680	COG1216	Glycosyl transferase, family 2
GIY23_00685	COG0671	phosphoesterase, PA-phosphatase related
GIY23_00690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GIY23_00695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GIY23_00710	COG2337	Toxic component of a toxin-antitoxin (TA) module
GIY23_00725	COG2161	toxin-antitoxin pair type II binding
GIY23_00730	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_00735	COG0277	FAD linked oxidase domain protein
GIY23_00745	COG2246	polysaccharide biosynthetic process
GIY23_00770	COG1216	Glycosyl transferase, family 2
GIY23_00795	COG1063	alcohol dehydrogenase
GIY23_00800	COG2234	aminopeptidase activity
GIY23_00825	COG1131	(ABC) transporter
GIY23_00870	COG0640	Transcriptional regulator
GIY23_00875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIY23_00880	COG2814	Major facilitator Superfamily
GIY23_00895	COG1414	Transcriptional regulator
GIY23_00925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GIY23_00935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIY23_00965	COG0697	spore germination
GIY23_00980	COG1620	l-lactate permease
GIY23_00985	COG2186	Transcriptional regulator
GIY23_01010	COG0287	Prephenate dehydrogenase
GIY23_01020	COG0590	tRNA wobble adenosine to inosine editing
GIY23_01045	COG2890	protein-(glutamine-N5) methyltransferase activity
GIY23_01090	COG1505	serine-type exopeptidase activity
GIY23_01095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GIY23_01100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GIY23_01110	COG0747	negative chemotaxis
GIY23_01115	COG0601	transmembrane transport
GIY23_01120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIY23_01125	COG0444	Belongs to the ABC transporter superfamily
GIY23_01130	COG4608	Belongs to the ABC transporter superfamily
GIY23_01140	COG0583	DNA-binding transcription factor activity
GIY23_01155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIY23_01170	COG3844	kynureninase activity
GIY23_01175	COG0778	Nitroreductase
GIY23_01175	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GIY23_01220	COG1070	Carbohydrate kinase
GIY23_01260	COG0657	acetylesterase activity
GIY23_01270	COG0783	Belongs to the Dps family
GIY23_01275	COG1902	pentaerythritol trinitrate reductase activity
GIY23_01310	COG1408	metallophosphoesterase
GIY23_01325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIY23_01335	COG2894	cell division
GIY23_01370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIY23_01400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIY23_01405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GIY23_01420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_01425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIY23_01440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GIY23_01445	COG1737	Transcriptional regulator
GIY23_01450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GIY23_01455	COG3876	Protein conserved in bacteria
GIY23_01460	COG1472	Belongs to the glycosyl hydrolase 3 family
GIY23_01510	COG1205	dead DEAH box helicase
GIY23_01510	COG1111	helicase
GIY23_01515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GIY23_01520	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GIY23_01535	COG1754	DNA topoisomerase type I activity
GIY23_01535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GIY23_01545	COG0470	DNA polymerase III
GIY23_01575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GIY23_01580	COG2027	D-alanyl-D-alanine carboxypeptidase
GIY23_01590	COG0037	tRNA processing
GIY23_01600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIY23_01610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GIY23_01615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GIY23_01650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GIY23_01655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GIY23_01660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GIY23_01665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GIY23_01690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GIY23_01705	COG1194	a g-specific adenine glycosylase
GIY23_01710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GIY23_01725	COG1329	Transcriptional regulator
GIY23_01730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GIY23_01735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GIY23_01770	COG0215	cysteine-tRNA ligase activity
GIY23_01775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIY23_01790	COG0733	neurotransmitter:sodium symporter activity
GIY23_01825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GIY23_01830	COG3842	ATPase activity
GIY23_01840	COG1609	Transcriptional regulator
GIY23_01845	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GIY23_01850	COG3766	membrane
GIY23_01875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GIY23_01890	COG0582	viral genome integration into host DNA
GIY23_01915	COG1674	ftsk spoiiie
GIY23_01950	COG1132	(ABC) transporter
GIY23_02010	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_02010	COG3347	Dehydrogenase
GIY23_02020	COG4585	Histidine kinase
GIY23_02025	COG2197	response regulator
GIY23_02040	COG0456	acetyltransferase
GIY23_02045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GIY23_02050	COG1917	Cupin 2, conserved barrel domain protein
GIY23_02055	COG5285	phytanoyl-CoA dioxygenase
GIY23_02110	COG2971	BadF BadG BcrA BcrD
GIY23_02115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GIY23_02120	COG2188	Transcriptional regulator
GIY23_02135	COG0352	thiamine-phosphate diphosphorylase activity
GIY23_02150	COG2022	thiamine diphosphate biosynthetic process
GIY23_02165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GIY23_02205	COG0688	phosphatidylethanolamine metabolic process
GIY23_02225	COG1278	Cold shock
GIY23_02235	COG0459	protein refolding
GIY23_02240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GIY23_02240	COG3291	Pkd domain containing protein
GIY23_02310	COG4948	Mandelate Racemase Muconate Lactonizing
GIY23_02345	COG1116	anion transmembrane transporter activity
GIY23_02350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GIY23_02360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GIY23_02415	COG1652	LysM domain
GIY23_02425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GIY23_02460	COG3304	Inner membrane component domain
GIY23_02465	COG0384	phenazine biosynthesis protein PhzF
GIY23_02470	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_02475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIY23_02510	COG2814	Major facilitator Superfamily
GIY23_02555	COG2252	PERMEase
GIY23_02565	COG2814	Major facilitator Superfamily
GIY23_02580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIY23_02585	COG1120	ATPase activity
GIY23_02595	COG2814	Major facilitator Superfamily
GIY23_02600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIY23_02625	COG0259	pyridoxamine-phosphate oxidase activity
GIY23_02635	COG0531	amino acid
GIY23_02655	COG2017	converts alpha-aldose to the beta-anomer
GIY23_02660	COG1960	acyl-CoA dehydrogenase activity
GIY23_02680	COG0415	Belongs to the DNA photolyase family
GIY23_02690	COG2130	NADP-dependent
GIY23_02705	COG1674	ftsk spoiiie
GIY23_02735	COG2267	carboxylic ester hydrolase activity
GIY23_02745	COG5632	N-Acetylmuramoyl-L-alanine amidase
GIY23_02745	COG3409	Peptidoglycan-binding domain 1 protein
GIY23_02750	COG1276	copper resistance
GIY23_02760	COG0438	transferase activity, transferring glycosyl groups
GIY23_02765	COG2267	carboxylic ester hydrolase activity
GIY23_02785	COG0667	Aldo Keto reductase
GIY23_02790	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_02795	COG5001	Diguanylate cyclase
GIY23_02835	COG0569	domain protein
GIY23_02840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIY23_02860	COG2267	carboxylic ester hydrolase activity
GIY23_02875	COG1764	response to oxidative stress
GIY23_02880	COG0667	Aldo Keto reductase
GIY23_02885	COG1063	alcohol dehydrogenase
GIY23_02890	COG1846	Transcriptional regulator
GIY23_02895	COG2860	membrane
GIY23_02910	COG0778	Nitroreductase
GIY23_02915	COG0254	rRNA binding
GIY23_02925	COG2205	protein histidine kinase activity
GIY23_02930	COG1349	DNA-binding transcription factor activity
GIY23_02940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIY23_02945	COG0521	Mo-molybdopterin cofactor biosynthetic process
GIY23_02945	COG0315	cyclic pyranopterin monophosphate synthase activity
GIY23_02975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GIY23_02980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GIY23_02990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIY23_03040	COG1309	transcriptional regulator
GIY23_03050	COG2353	YceI-like domain
GIY23_03095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIY23_03100	COG0084	hydrolase, TatD family'
GIY23_03105	COG1652	LysM domain
GIY23_03110	COG3583	domain protein
GIY23_03115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GIY23_03120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GIY23_03125	COG2011	ABC-type metal ion transport system permease component
GIY23_03130	COG1464	Belongs to the NlpA lipoprotein family
GIY23_03135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GIY23_03140	COG0488	(ABC) transporter
GIY23_03145	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_03150	COG0193	aminoacyl-tRNA hydrolase activity
GIY23_03170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GIY23_03190	COG1309	transcriptional regulator
GIY23_03205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GIY23_03225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GIY23_03235	COG4644	lycopene metabolic process
GIY23_03285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIY23_03290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIY23_03300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIY23_03310	COG1937	Protein conserved in bacteria
GIY23_03425	COG1278	Cold shock
GIY23_03435	COG1278	Cold shock
GIY23_03500	COG2133	pyrroloquinoline quinone binding
GIY23_03510	COG1316	TRANSCRIPTIONal
GIY23_03555	COG0148	phosphopyruvate hydratase activity
GIY23_03580	COG4166	transmembrane transport
GIY23_03585	COG0601	transmembrane transport
GIY23_03590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIY23_03600	COG4608	Belongs to the ABC transporter superfamily
GIY23_03655	COG3654	unkown
GIY23_03660	COG0640	Transcriptional regulator
GIY23_03695	COG0667	Aldo Keto reductase
GIY23_03720	COG1802	Transcriptional regulator
GIY23_03735	COG1953	Uracil, thiamine, allantoin
GIY23_03780	COG0183	Belongs to the thiolase family
GIY23_03785	COG2755	lipolytic protein G-D-S-L family
GIY23_03795	COG1714	RDD family
GIY23_03810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GIY23_03815	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GIY23_03820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIY23_03830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GIY23_03840	COG1331	Highly conserved protein containing a thioredoxin domain
GIY23_03870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIY23_03875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GIY23_03890	COG1793	dna ligase
GIY23_03895	COG0114	fumarate hydratase activity
GIY23_03905	COG0492	ferredoxin-NADP+ reductase activity
GIY23_03920	COG1722	exodeoxyribonuclease VII activity
GIY23_03930	COG1570	exodeoxyribonuclease VII activity
GIY23_03950	COG1129	ABC transporter
GIY23_03955	COG1172	Belongs to the binding-protein-dependent transport system permease family
GIY23_03960	COG1879	ABC-type sugar transport system periplasmic component
GIY23_03975	COG1609	Transcriptional regulator
GIY23_03985	COG1070	Carbohydrate kinase
GIY23_04010	COG0420	3'-5' exonuclease activity
GIY23_04015	COG0419	ATPase involved in DNA repair
GIY23_04020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GIY23_04020	COG2169	Transcriptional regulator
GIY23_04035	COG0012	GTP binding
GIY23_04075	COG2353	YceI-like domain
GIY23_04125	COG0277	FAD linked oxidase domain protein
GIY23_04135	COG0156	8-amino-7-oxononanoate synthase activity
GIY23_04140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GIY23_04145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GIY23_04155	COG1357	PFAM Pentapeptide repeats (8 copies)
GIY23_04160	COG2154	pterin-4-alpha-carbinolamine dehydratase
GIY23_04175	COG3842	ATPase activity
GIY23_04185	COG1131	(ABC) transporter
GIY23_04195	COG0745	RESPONSE REGULATOR receiver
GIY23_04200	COG2205	protein histidine kinase activity
GIY23_04205	COG0494	nUDIX hydrolase
GIY23_04215	COG0488	(ABC) transporter
GIY23_04220	COG0180	Tryptophanyl-tRNA synthetase
GIY23_04235	COG1217	gtp-binding protein TYPA
GIY23_04240	COG0747	negative chemotaxis
GIY23_04250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GIY23_04275	COG2171	N-acyltransferase activity
GIY23_04280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIY23_04285	COG0330	HflC and HflK could
GIY23_04290	COG1611	Belongs to the LOG family
GIY23_04295	COG1611	Belongs to the LOG family
GIY23_04300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GIY23_04325	COG0519	Catalyzes the synthesis of GMP from XMP
GIY23_04330	COG1024	Enoyl-CoA hydratase
GIY23_04345	COG0583	DNA-binding transcription factor activity
GIY23_04350	COG2814	Major facilitator Superfamily
GIY23_04355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIY23_04360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIY23_04365	COG5662	AntiSigma factor
GIY23_04385	COG2239	Acts as a magnesium transporter
GIY23_04390	COG2301	Belongs to the HpcH HpaI aldolase family
GIY23_04395	COG1752	Esterase of the alpha-beta hydrolase superfamily
GIY23_04400	COG3384	dioxygenase
GIY23_04435	COG0598	Magnesium transport protein CorA
GIY23_04440	COG0406	alpha-ribazole phosphatase activity
GIY23_04440	COG0494	nUDIX hydrolase
GIY23_04450	COG0613	PHP domain protein
GIY23_04470	COG0513	Belongs to the DEAD box helicase family
GIY23_04505	COG4981	capsule polysaccharide biosynthetic process
GIY23_04530	COG0297	glycogen (starch) synthase activity
GIY23_04580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GIY23_04590	COG2267	carboxylic ester hydrolase activity
GIY23_04620	COG0210	DNA helicase
GIY23_04645	COG0210	DNA helicase
GIY23_04655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GIY23_04670	COG1715	Restriction endonuclease
GIY23_04680	COG2815	serine threonine protein kinase
GIY23_04680	COG0515	serine threonine protein kinase
GIY23_04725	COG0612	Peptidase, M16
GIY23_04735	COG1396	sequence-specific DNA binding
GIY23_04765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIY23_04770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GIY23_04795	COG1615	UPF0182 protein
GIY23_04815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GIY23_04820	COG2884	Cell division ATP-binding protein ftsE
GIY23_04825	COG2177	Part of the ABC transporter FtsEX involved in
GIY23_04830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GIY23_04870	COG0438	transferase activity, transferring glycosyl groups
GIY23_04885	COG0564	pseudouridine synthase activity
GIY23_04905	COG2814	Major facilitator Superfamily
GIY23_04920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GIY23_04955	COG1674	ftsk spoiiie
GIY23_05055	COG3012	SEC-C Motif Domain Protein
GIY23_05070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GIY23_05080	COG0346	lactoylglutathione lyase activity
GIY23_05095	COG0515	serine threonine protein kinase
GIY23_05095	COG2815	serine threonine protein kinase
GIY23_05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GIY23_05110	COG1960	acyl-CoA dehydrogenase activity
GIY23_05115	COG1960	acyl-CoA dehydrogenase activity
GIY23_05125	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_05135	COG0477	Major facilitator Superfamily
GIY23_05145	COG1309	transcriptional regulator
GIY23_05165	COG2188	Transcriptional regulator
GIY23_05225	COG1053	succinate dehydrogenase
GIY23_05270	COG0667	Aldo Keto reductase
GIY23_05275	COG0702	epimerase
GIY23_05285	COG1122	ATPase activity
GIY23_05300	COG1268	BioY protein
GIY23_05310	COG1335	isochorismatase
GIY23_05315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GIY23_05330	COG3191	aminopeptidase activity
GIY23_05360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GIY23_05375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GIY23_05380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GIY23_05395	COG0028	Belongs to the TPP enzyme family
GIY23_05455	COG1733	regulation of RNA biosynthetic process
GIY23_05515	COG0590	tRNA wobble adenosine to inosine editing
GIY23_05520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIY23_05535	COG0019	diaminopimelate decarboxylase activity
GIY23_05540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GIY23_05610	COG0129	dihydroxy-acid dehydratase activity
GIY23_05620	COG1595	DNA-templated transcription, initiation
GIY23_05625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GIY23_05645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GIY23_05655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIY23_05660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GIY23_05660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIY23_05665	COG1473	amidohydrolase
GIY23_05670	COG0488	(ABC) transporter
GIY23_05685	COG2080	2 iron, 2 sulfur cluster binding
GIY23_05705	COG2311	Membrane
GIY23_05740	COG1376	ErfK ybiS ycfS ynhG family protein
GIY23_05755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GIY23_05760	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_05785	COG0352	thiamine-phosphate diphosphorylase activity
GIY23_05795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GIY23_05820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_05830	COG0109	protoheme IX farnesyltransferase activity
GIY23_05850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GIY23_05875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GIY23_05895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GIY23_05910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIY23_05910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_05915	COG0009	L-threonylcarbamoyladenylate synthase
GIY23_05930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GIY23_05945	COG1063	alcohol dehydrogenase
GIY23_05960	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_05970	COG2226	methyltransferase
GIY23_06005	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_06110	COG2902	Dehydrogenase
GIY23_06115	COG0824	Thioesterase
GIY23_06130	COG0366	Alpha amylase catalytic
GIY23_06140	COG0668	transmembrane transport
GIY23_06145	COG1505	serine-type exopeptidase activity
GIY23_06165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GIY23_06175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GIY23_06190	COG0698	ribose 5-phosphate isomerase
GIY23_06215	COG2814	Major facilitator Superfamily
GIY23_06225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIY23_06235	COG0477	Major facilitator Superfamily
GIY23_06275	COG0544	peptidyl-prolyl cis-trans isomerase activity
GIY23_06280	COG0740	serine-type endopeptidase activity
GIY23_06285	COG0740	serine-type endopeptidase activity
GIY23_06290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GIY23_06305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GIY23_06350	COG0525	valine-tRNA ligase activity
GIY23_06355	COG0285	dihydrofolate synthase activity
GIY23_06385	COG0105	UTP biosynthetic process
GIY23_06405	COG1530	ribonuclease E activity
GIY23_06410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GIY23_06415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GIY23_06420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GIY23_06430	COG0477	Major facilitator Superfamily
GIY23_06435	COG0514	ATP-dependent DNA helicase (RecQ)
GIY23_06440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GIY23_06455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GIY23_06490	COG0110	maltose O-acetyltransferase activity
GIY23_06500	COG0799	negative regulation of ribosome biogenesis
GIY23_06505	COG0406	alpha-ribazole phosphatase activity
GIY23_06510	COG1307	EDD domain protein, DegV family
GIY23_06520	COG1555	photosystem II stabilization
GIY23_06525	COG0658	competence protein
GIY23_06525	COG2333	competence protein COMEC
GIY23_06540	COG0268	Binds directly to 16S ribosomal RNA
GIY23_06565	COG0481	GTPase activity
GIY23_06605	COG4638	Rieske (2fe-2S)
GIY23_06610	COG0583	DNA-binding transcription factor activity
GIY23_06620	COG3485	protocatechuate 3,4-dioxygenase
GIY23_06625	COG4829	muconolactone delta-isomerase
GIY23_06635	COG0183	Belongs to the thiolase family
GIY23_06645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GIY23_06650	COG0492	ferredoxin-NADP+ reductase activity
GIY23_06655	COG2070	2-Nitropropane dioxygenase
GIY23_06670	COG1960	acyl-CoA dehydrogenase activity
GIY23_06695	COG2732	(Barnase) inhibitor
GIY23_06700	COG1024	Enoyl-CoA hydratase
GIY23_06755	COG1420	regulation of RNA biosynthetic process
GIY23_06760	COG0484	heat shock protein binding
GIY23_06770	COG0537	adenosine 5'-monophosphoramidase activity
GIY23_06780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GIY23_06795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GIY23_06825	COG1381	Involved in DNA repair and RecF pathway recombination
GIY23_06835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GIY23_06845	COG0701	Predicted permease
GIY23_06870	COG0423	glycine-tRNA ligase activity
GIY23_06900	COG1595	DNA-templated transcription, initiation
GIY23_06915	COG4106	trans-aconitate 2-methyltransferase activity
GIY23_06965	COG2826	transposase and inactivated derivatives, IS30 family
GIY23_07010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GIY23_07015	COG0477	Major facilitator Superfamily
GIY23_07080	COG1966	Carbon starvation protein
GIY23_07130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GIY23_07135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GIY23_07165	COG3201	nicotinamide mononucleotide transporter
GIY23_07170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GIY23_07230	COG3226	Transcriptional regulator
GIY23_07245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIY23_07260	COG2119	membrane
GIY23_07290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GIY23_07315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GIY23_07360	COG0791	NLP P60 protein
GIY23_07360	COG3883	PFAM NLP P60 protein
GIY23_07375	COG0557	exoribonuclease II activity
GIY23_07390	COG0435	Glutathione S-transferase
GIY23_07395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GIY23_07405	COG0174	glutamine synthetase
GIY23_07440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GIY23_07450	COG2746	aminoglycoside 3-N-acetyltransferase activity
GIY23_07455	COG0174	glutamine synthetase
GIY23_07470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GIY23_07480	COG0321	lipoyl(octanoyl) transferase activity
GIY23_07490	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_07495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIY23_07510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GIY23_07530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GIY23_07550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GIY23_07560	COG0667	Aldo Keto reductase
GIY23_07595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GIY23_07620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GIY23_07635	COG1845	cytochrome c oxidase, subunit III
GIY23_07710	COG0003	Pfam Anion-transporting ATPase
GIY23_07720	COG1940	carbohydrate kinase activity
GIY23_07750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GIY23_07765	COG2815	serine threonine protein kinase
GIY23_07765	COG0515	serine threonine protein kinase
GIY23_07790	COG0142	geranyltranstransferase activity
GIY23_07820	COG1201	RNA secondary structure unwinding
GIY23_07835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GIY23_07840	COG2137	regulation of response to DNA damage stimulus
GIY23_07850	COG0800	Aldolase
GIY23_07860	COG0765	amino acid transport
GIY23_07865	COG0765	amino acid transport
GIY23_07870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIY23_07875	COG1126	abc transporter atp-binding protein
GIY23_07880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIY23_07890	COG1196	nuclear chromosome segregation
GIY23_07900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GIY23_07910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GIY23_07930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GIY23_07935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIY23_07945	COG2936	dipeptidyl-peptidase activity
GIY23_07950	COG0739	heme binding
GIY23_07965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GIY23_07980	COG0123	including yeast histone deacetylase and acetoin utilization protein
GIY23_08000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GIY23_08000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GIY23_08015	COG1490	D-aminoacyl-tRNA deacylase activity
GIY23_08035	COG2032	superoxide dismutase activity
GIY23_08080	COG0483	inositol monophosphate 1-phosphatase activity
GIY23_08100	COG0756	dUTP diphosphatase activity
GIY23_08125	COG0569	domain protein
GIY23_08130	COG0531	amino acid
GIY23_08135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIY23_08160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GIY23_08165	COG0745	RESPONSE REGULATOR receiver
GIY23_08170	COG2205	protein histidine kinase activity
GIY23_08180	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIY23_08180	COG1024	Enoyl-CoA hydratase
GIY23_08185	COG0183	Belongs to the thiolase family
GIY23_08190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GIY23_08195	COG2197	response regulator
GIY23_08210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GIY23_08220	COG3253	May function as heme-dependent peroxidase
GIY23_08235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GIY23_08280	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_08290	COG1793	dna ligase
GIY23_08350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GIY23_08355	COG2706	6-phosphogluconolactonase activity
GIY23_08390	COG1129	ABC transporter
GIY23_08395	COG1172	Belongs to the binding-protein-dependent transport system permease family
GIY23_08415	COG0693	protein deglycase activity
GIY23_08440	COG1802	Transcriptional regulator
GIY23_08445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GIY23_08450	COG1960	acyl-CoA dehydrogenase activity
GIY23_08455	COG0154	amidase activity
GIY23_08470	COG3851	Histidine kinase
GIY23_08475	COG2197	response regulator
GIY23_08480	COG0673	inositol 2-dehydrogenase activity
GIY23_08485	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GIY23_08495	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_08520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIY23_08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_08535	COG0667	Aldo Keto reductase
GIY23_08540	COG1950	PFAM Membrane protein of
GIY23_08550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GIY23_08560	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GIY23_08565	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIY23_08675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_08675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIY23_08715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GIY23_08720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GIY23_08740	COG2409	Drug exporters of the RND superfamily
GIY23_08790	COG3268	Saccharopine dehydrogenase
GIY23_08810	COG0583	DNA-binding transcription factor activity
GIY23_08830	COG0656	L-ascorbic acid biosynthetic process
GIY23_08840	COG0506	proline dehydrogenase activity
GIY23_08865	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GIY23_08870	COG0277	FAD linked oxidase domain protein
GIY23_08875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GIY23_08895	COG3300	MHYT domain
GIY23_08895	COG5001	Diguanylate cyclase
GIY23_08900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GIY23_08915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GIY23_08925	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GIY23_08935	COG1396	sequence-specific DNA binding
GIY23_08950	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GIY23_08955	COG0217	transcriptional regulatory protein
GIY23_08965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GIY23_08970	COG0632	four-way junction helicase activity
GIY23_08975	COG2255	four-way junction helicase activity
GIY23_08990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIY23_08995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GIY23_09005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GIY23_09010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GIY23_09020	COG0124	histidyl-tRNA synthetase
GIY23_09030	COG1309	transcriptional regulator
GIY23_09070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GIY23_09085	COG0288	reversible hydration of carbon dioxide
GIY23_09115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GIY23_09120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GIY23_09130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GIY23_09135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIY23_09140	COG1263	PTS System
GIY23_09145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIY23_09160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GIY23_09165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GIY23_09170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GIY23_09175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GIY23_09180	COG0006	proline dipeptidase activity
GIY23_09185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GIY23_09190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIY23_09205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GIY23_09210	COG0540	Belongs to the ATCase OTCase family
GIY23_09225	COG0505	Belongs to the CarA family
GIY23_09235	COG0284	orotidine-5'-phosphate decarboxylase activity
GIY23_09290	COG0194	GDP metabolic process
GIY23_09295	COG1758	RNA polymerase activity
GIY23_09305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GIY23_09310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GIY23_09320	COG0405	Gamma-glutamyltransferase
GIY23_09325	COG0242	peptide deformylase activity
GIY23_09330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GIY23_09340	COG0037	tRNA processing
GIY23_09340	COG0590	tRNA wobble adenosine to inosine editing
GIY23_09350	COG1113	amino acid transport
GIY23_09370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIY23_09370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIY23_09375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GIY23_09385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GIY23_09385	COG1796	DNA polymerase
GIY23_09390	COG0167	dihydroorotate dehydrogenase activity
GIY23_09430	COG0322	excinuclease ABC activity
GIY23_09435	COG1660	Displays ATPase and GTPase activities
GIY23_09445	COG1481	regulation of sporulation
GIY23_09450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GIY23_09455	COG0126	phosphoglycerate kinase activity
GIY23_09460	COG0149	triose-phosphate isomerase activity
GIY23_09475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIY23_09485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIY23_09495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GIY23_09520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GIY23_09525	COG0298	carbon dioxide binding
GIY23_09530	COG0409	Hydrogenase expression formation protein
GIY23_09540	COG0375	protein maturation
GIY23_09550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GIY23_09555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GIY23_09560	COG0363	glucosamine-6-phosphate deaminase activity
GIY23_09575	COG0166	Belongs to the GPI family
GIY23_09580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GIY23_09600	COG1510	regulation of RNA biosynthetic process
GIY23_09640	COG0719	Fe-S assembly protein
GIY23_09645	COG0396	ATPase activity
GIY23_09660	COG2151	metal-sulfur cluster biosynthetic enzyme
GIY23_09670	COG2199	diguanylate cyclase activity
GIY23_09670	COG2200	EAL domain
GIY23_09670	COG2203	Gaf domain
GIY23_09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIY23_09685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIY23_09690	COG0488	(ABC) transporter
GIY23_09700	COG1024	Enoyl-CoA hydratase
GIY23_09715	COG2362	D-Aminopeptidase
GIY23_09725	COG0601	transmembrane transport
GIY23_09730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIY23_09745	COG1619	proteins homologs of microcin C7 resistance protein MccF
GIY23_09785	COG0215	cysteine-tRNA ligase activity
GIY23_09795	COG2205	protein histidine kinase activity
GIY23_09800	COG2018	Roadblock/LC7 domain
GIY23_09835	COG0140	phosphoribosyl-ATP diphosphatase activity
GIY23_09840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GIY23_09850	COG2318	DinB family
GIY23_09865	COG0517	IMP dehydrogenase activity
GIY23_09865	COG1994	Peptidase M50
GIY23_09890	COG1222	aaa ATPase
GIY23_09915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GIY23_09920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GIY23_09930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GIY23_09960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIY23_09980	COG4552	Acetyltransferase involved in intracellular survival and related
GIY23_10005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIY23_10020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIY23_10020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIY23_10020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIY23_10025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIY23_10025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIY23_10030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIY23_10035	COG1621	beta-fructofuranosidase activity
GIY23_10055	COG3030	protein affecting phage T7 exclusion by the F plasmid
GIY23_10070	COG0463	Glycosyl transferase, family 2
GIY23_10080	COG2270	Major facilitator Superfamily
GIY23_10115	COG0596	Alpha beta hydrolase
GIY23_10120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIY23_10130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GIY23_10135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIY23_10140	COG0646	methionine synthase
GIY23_10140	COG1410	methionine synthase
GIY23_10145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GIY23_10175	COG0277	FAD linked oxidase domain protein
GIY23_10185	COG0022	dehydrogenase e1 component
GIY23_10195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GIY23_10225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GIY23_10235	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GIY23_10265	COG1716	ATPase activity
GIY23_10280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIY23_10280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIY23_10310	COG3104	oligopeptide transport
GIY23_10325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GIY23_10330	COG0121	glutamine amidotransferase
GIY23_10335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GIY23_10355	COG0693	protein deglycase activity
GIY23_10375	COG2146	nitrite reductase [NAD(P)H] activity
GIY23_10375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIY23_10380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIY23_10385	COG0243	molybdopterin cofactor binding
GIY23_10390	COG2223	nitrite transmembrane transporter activity
GIY23_10405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GIY23_10410	COG5006	permease, DMT superfamily
GIY23_10425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GIY23_10430	COG0791	NLP P60 protein
GIY23_10430	COG3883	PFAM NLP P60 protein
GIY23_10435	COG0746	molybdenum cofactor guanylyltransferase activity
GIY23_10455	COG0714	Associated with various cellular activities
GIY23_10465	COG2304	oxidoreductase activity
GIY23_10475	COG0247	lactate metabolic process
GIY23_10475	COG0277	FAD linked oxidase domain protein
GIY23_10480	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_10485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GIY23_10490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GIY23_10530	COG4691	Plasmid stability protein
GIY23_10540	COG4221	oxidoreductase activity
GIY23_10555	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_10560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GIY23_10595	COG2186	Transcriptional regulator
GIY23_10610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GIY23_10615	COG1316	TRANSCRIPTIONal
GIY23_10645	COG0542	response to heat
GIY23_10665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GIY23_10710	COG1914	H( )-stimulated, divalent metal cation uptake system
GIY23_10720	COG2814	Major facilitator Superfamily
GIY23_10725	COG1063	alcohol dehydrogenase
GIY23_10740	COG2890	protein-(glutamine-N5) methyltransferase activity
GIY23_10750	COG4122	O-methyltransferase activity
GIY23_10765	COG0702	epimerase
GIY23_10775	COG2264	protein methyltransferase activity
GIY23_10780	COG2197	response regulator
GIY23_10785	COG3851	Histidine kinase
GIY23_10795	COG0577	efflux transmembrane transporter activity
GIY23_10795	COG1136	(ABC) transporter
GIY23_10800	COG0488	(ABC) transporter
GIY23_10815	COG0039	L-malate dehydrogenase activity
GIY23_10820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GIY23_10840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GIY23_10865	COG0789	Transcriptional regulator
GIY23_10870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GIY23_10875	COG0798	PFAM Bile acid sodium symporter
GIY23_10880	COG0640	Transcriptional regulator
GIY23_10885	COG2226	methyltransferase
GIY23_10895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIY23_10910	COG2132	Multicopper oxidase
GIY23_10970	COG1278	Cold shock
GIY23_10990	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_10995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIY23_11020	COG1819	glycosyl
GIY23_11030	COG1309	transcriptional regulator
GIY23_11065	COG3314	Sporulation integral membrane protein YlbJ
GIY23_11070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GIY23_11105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIY23_11130	COG0483	inositol monophosphate 1-phosphatase activity
GIY23_11135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GIY23_11160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GIY23_11165	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_11170	COG0561	phosphatase activity
GIY23_11185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIY23_11240	COG1968	undecaprenyl-diphosphatase activity
GIY23_11255	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GIY23_11275	COG0740	serine-type endopeptidase activity
GIY23_11345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GIY23_11355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIY23_11355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIY23_11360	COG0431	NADPH-dependent FMN reductase
GIY23_11370	COG0730	response to heat
GIY23_11395	COG0237	dephospho-CoA kinase activity
GIY23_11420	COG0640	Transcriptional regulator
GIY23_11430	COG2318	DinB family
GIY23_11445	COG1492	cobalamin metabolic process
GIY23_11450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GIY23_11470	COG2235	arginine
GIY23_11475	COG3842	ATPase activity
GIY23_11480	COG0366	Alpha amylase catalytic
GIY23_11500	COG1609	Transcriptional regulator
GIY23_11505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GIY23_11510	COG3285	dna ligase
GIY23_11510	COG1793	dna ligase
GIY23_11515	COG0542	response to heat
GIY23_11530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIY23_11535	COG2151	metal-sulfur cluster biosynthetic enzyme
GIY23_11540	COG3396	Phenylacetate-CoA oxygenase
GIY23_11545	COG3460	Phenylacetate-CoA oxygenase
GIY23_11550	COG3396	Phenylacetate-CoA oxygenase
GIY23_11555	COG2030	dehydratase
GIY23_11555	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_11605	COG1404	Belongs to the peptidase S8 family
GIY23_11640	COG1024	Enoyl-CoA hydratase
GIY23_11655	COG1218	3'(2'),5'-bisphosphate nucleotidase
GIY23_11660	COG0529	Catalyzes the synthesis of activated sulfate
GIY23_11680	COG0174	glutamine synthetase
GIY23_11690	COG1132	(ABC) transporter
GIY23_11700	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_11715	COG1522	sequence-specific DNA binding
GIY23_11805	COG3973	AAA domain
GIY23_11835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GIY23_11840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIY23_11845	COG2508	Transcriptional regulator
GIY23_11845	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GIY23_11865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIY23_11870	COG0590	tRNA wobble adenosine to inosine editing
GIY23_11875	COG2252	PERMEase
GIY23_11890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GIY23_11895	COG1929	Belongs to the glycerate kinase type-1 family
GIY23_11900	COG3960	tartronate-semialdehyde synthase activity
GIY23_11905	COG2084	Dehydrogenase
GIY23_11910	COG3622	Belongs to the hyi family
GIY23_11930	COG2351	hydroxyisourate hydrolase activity
GIY23_11940	COG2233	PERMEase
GIY23_11945	COG3257	ureidoglycine aminohydrolase activity
GIY23_11975	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_11990	COG1846	Transcriptional regulator
GIY23_11990	COG1940	carbohydrate kinase activity
GIY23_12070	COG1966	Carbon starvation protein
GIY23_12090	COG0673	inositol 2-dehydrogenase activity
GIY23_12105	COG2271	Major facilitator Superfamily
GIY23_12170	COG0667	Aldo Keto reductase
GIY23_12195	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
GIY23_12215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GIY23_12240	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_12245	COG0583	DNA-binding transcription factor activity
GIY23_12280	COG0477	Major facilitator Superfamily
GIY23_12285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIY23_12320	COG0640	Transcriptional regulator
GIY23_12325	COG0798	PFAM Bile acid sodium symporter
GIY23_12330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GIY23_12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIY23_12345	COG2814	Major facilitator Superfamily
GIY23_12360	COG2072	flavoprotein involved in K transport
GIY23_12370	COG1007	ATP synthesis coupled electron transport
GIY23_12375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIY23_12395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GIY23_12410	COG1937	Protein conserved in bacteria
GIY23_12445	COG2814	Major facilitator Superfamily
GIY23_12450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIY23_12475	COG2132	Multicopper oxidase
GIY23_12510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIY23_12550	COG2132	Multicopper oxidase
GIY23_12565	COG0501	Belongs to the peptidase M48B family
GIY23_12575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIY23_12585	COG3088	subunit of a heme lyase
GIY23_12590	COG1138	Cytochrome C-type biogenesis protein
GIY23_12595	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GIY23_12600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIY23_12615	COG0785	Cytochrome C biogenesis protein
GIY23_12645	COG3328	transposase activity
GIY23_12660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_12660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIY23_12685	COG0640	Transcriptional regulator
GIY23_12720	COG2217	Heavy metal translocating P-type atpase
GIY23_12735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GIY23_12750	COG4106	trans-aconitate 2-methyltransferase activity
GIY23_12775	COG3328	transposase activity
GIY23_12780	COG3328	transposase activity
GIY23_12805	COG0494	nUDIX hydrolase
GIY23_12955	COG0739	heme binding
GIY23_12955	COG0741	lytic transglycosylase activity
GIY23_12955	COG1196	nuclear chromosome segregation
GIY23_13045	COG4974	Belongs to the 'phage' integrase family
GIY23_13060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIY23_13075	COG0300	oxidoreductase activity
GIY23_13100	COG1013	pyruvate-flavodoxin oxidoreductase activity
GIY23_13105	COG0674	pyruvate-flavodoxin oxidoreductase activity
GIY23_13105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GIY23_13110	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_13120	COG1024	Enoyl-CoA hydratase
GIY23_13140	COG1309	transcriptional regulator
GIY23_13150	COG1960	acyl-CoA dehydrogenase activity
GIY23_13155	COG1024	Enoyl-CoA hydratase
GIY23_13160	COG1960	acyl-CoA dehydrogenase activity
GIY23_13165	COG1960	acyl-CoA dehydrogenase activity
GIY23_13165	COG1960	acyl-CoA dehydrogenase activity
GIY23_13170	COG1960	acyl-CoA dehydrogenase activity
GIY23_13210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GIY23_13225	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_13230	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_13245	COG1960	acyl-CoA dehydrogenase activity
GIY23_13250	COG1960	acyl-CoA dehydrogenase activity
GIY23_13255	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_13260	COG2070	2-Nitropropane dioxygenase
GIY23_13270	COG1024	Enoyl-CoA hydratase
GIY23_13310	COG2124	cytochrome p450
GIY23_13315	COG0183	Belongs to the thiolase family
GIY23_13320	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_13325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GIY23_13330	COG0346	lactoylglutathione lyase activity
GIY23_13335	COG2267	carboxylic ester hydrolase activity
GIY23_13340	COG1960	acyl-CoA dehydrogenase activity
GIY23_13345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIY23_13350	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GIY23_13365	COG1053	succinate dehydrogenase
GIY23_13385	COG2030	dehydratase
GIY23_13405	COG1960	acyl-CoA dehydrogenase activity
GIY23_13410	COG1960	acyl-CoA dehydrogenase activity
GIY23_13415	COG1960	acyl-CoA dehydrogenase activity
GIY23_13430	COG2226	methyltransferase
GIY23_13435	COG0438	transferase activity, transferring glycosyl groups
GIY23_13440	COG1309	transcriptional regulator
GIY23_13445	COG0183	Belongs to the thiolase family
GIY23_13450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GIY23_13465	COG2030	dehydratase
GIY23_13470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GIY23_13475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GIY23_13480	COG2233	PERMEase
GIY23_13490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_13495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GIY23_13500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GIY23_13520	COG4946	Tricorn protease homolog
GIY23_13520	COG1506	peptidase
GIY23_13520	COG0823	Involved in the tonB-independent uptake of proteins
GIY23_13530	COG1132	(ABC) transporter
GIY23_13535	COG1132	(ABC) transporter
GIY23_13570	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIY23_13575	COG3246	L-lysine catabolic process to acetate
GIY23_13580	COG1309	transcriptional regulator
GIY23_13585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GIY23_13600	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GIY23_13600	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GIY23_13610	COG1473	amidohydrolase
GIY23_13615	COG1476	TRANSCRIPTIONal
GIY23_13625	COG2226	methyltransferase
GIY23_13650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GIY23_13655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GIY23_13670	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GIY23_13690	COG1024	Enoyl-CoA hydratase
GIY23_13695	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_13700	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_13705	COG1960	acyl-CoA dehydrogenase activity
GIY23_13710	COG0604	alcohol dehydrogenase
GIY23_13710	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_13710	COG3321	synthase
GIY23_13715	COG2188	Transcriptional regulator
GIY23_13720	COG1960	acyl-CoA dehydrogenase activity
GIY23_13725	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GIY23_13730	COG2301	Belongs to the HpcH HpaI aldolase family
GIY23_13745	COG0542	response to heat
GIY23_13750	COG0667	Aldo Keto reductase
GIY23_13755	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_13775	COG0142	geranyltranstransferase activity
GIY23_13785	COG0702	epimerase
GIY23_13795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GIY23_13800	COG1253	flavin adenine dinucleotide binding
GIY23_13810	COG0762	integral membrane protein
GIY23_13815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_13830	COG4106	trans-aconitate 2-methyltransferase activity
GIY23_13840	COG4948	Mandelate Racemase Muconate Lactonizing
GIY23_13850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIY23_13855	COG0583	DNA-binding transcription factor activity
GIY23_13865	COG3250	beta-galactosidase activity
GIY23_13870	COG1609	Transcriptional regulator
GIY23_13875	COG1904	glucuronate isomerase
GIY23_13880	COG0246	Mannitol dehydrogenase
GIY23_13900	COG0437	4 iron, 4 sulfur cluster binding
GIY23_13925	COG0709	Synthesizes selenophosphate from selenide and ATP
GIY23_13945	COG2146	nitrite reductase [NAD(P)H] activity
GIY23_13965	COG4638	Rieske (2fe-2S)
GIY23_13975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GIY23_14000	COG1760	l-serine dehydratase
GIY23_14020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIY23_14085	COG1024	Enoyl-CoA hydratase
GIY23_14100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GIY23_14105	COG1960	acyl-CoA dehydrogenase activity
GIY23_14125	COG0668	transmembrane transport
GIY23_14150	COG5522	Integral membrane protein (intg_mem_TP0381)
GIY23_14165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIY23_14170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GIY23_14175	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_14185	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIY23_14185	COG1902	pentaerythritol trinitrate reductase activity
GIY23_14205	COG1174	glycine betaine transport
GIY23_14220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GIY23_14220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GIY23_14230	COG0247	lactate metabolic process
GIY23_14230	COG0277	FAD linked oxidase domain protein
GIY23_14250	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_14285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIY23_14290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIY23_14295	COG2080	2 iron, 2 sulfur cluster binding
GIY23_14315	COG0738	Major facilitator superfamily
GIY23_14335	COG3599	regulation of cell shape
GIY23_14355	COG1120	ATPase activity
GIY23_14360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIY23_14370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIY23_14375	COG1802	Transcriptional regulator
GIY23_14380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GIY23_14390	COG4145	pantothenate transmembrane transporter activity
GIY23_14400	COG1937	Protein conserved in bacteria
GIY23_14420	COG2261	transglycosylase associated protein
GIY23_14435	COG0400	carboxylic ester hydrolase activity
GIY23_14440	COG0346	lactoylglutathione lyase activity
GIY23_14445	COG0655	NAD(P)H dehydrogenase (quinone) activity
GIY23_14450	COG1846	Transcriptional regulator
GIY23_14465	COG0531	amino acid
GIY23_14475	COG2755	lipolytic protein G-D-S-L family
GIY23_14480	COG2234	aminopeptidase activity
GIY23_14480	COG4935	Belongs to the peptidase S8 family
GIY23_14485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIY23_14505	COG1160	GTP binding
GIY23_14525	COG0475	glutathione-regulated potassium exporter activity
GIY23_14560	COG0494	nUDIX hydrolase
GIY23_14565	COG0504	CTP synthase activity
GIY23_14590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GIY23_14605	COG0647	UMP catabolic process
GIY23_14635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GIY23_14640	COG2094	Belongs to the DNA glycosylase MPG family
GIY23_14645	COG0165	Argininosuccinate lyase
GIY23_14650	COG0137	argininosuccinate synthase activity
GIY23_14660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GIY23_14665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GIY23_14670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GIY23_14675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GIY23_14680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GIY23_14690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIY23_14695	COG2508	Transcriptional regulator
GIY23_14695	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GIY23_14700	COG0072	phenylalanine-tRNA ligase activity
GIY23_14700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIY23_14705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GIY23_14710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIY23_14715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GIY23_14720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GIY23_14740	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GIY23_14750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIY23_14770	COG0477	Major facilitator Superfamily
GIY23_14775	COG2356	endonuclease I
GIY23_14790	COG0708	Exodeoxyribonuclease III
GIY23_14815	COG2183	response to ionizing radiation
GIY23_14825	COG1960	acyl-CoA dehydrogenase activity
GIY23_14830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GIY23_14845	COG1024	Enoyl-CoA hydratase
GIY23_14850	COG1335	isochorismatase
GIY23_14870	COG3290	protein histidine kinase activity
GIY23_14875	COG4565	transcriptional regulatory protein
GIY23_14895	COG3226	Transcriptional regulator
GIY23_14900	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_14935	COG1011	Hydrolase
GIY23_14945	COG1960	acyl-CoA dehydrogenase activity
GIY23_14975	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_14995	COG1131	(ABC) transporter
GIY23_15035	COG0539	negative regulation of cytoplasmic translation
GIY23_15040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIY23_15100	COG0477	Major facilitator Superfamily
GIY23_15105	COG2313	pseudouridylate synthase activity
GIY23_15130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GIY23_15130	COG0825	malonyl-CoA metabolic process
GIY23_15135	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_15145	COG2186	Transcriptional regulator
GIY23_15150	COG2226	methyltransferase
GIY23_15155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIY23_15165	COG1063	alcohol dehydrogenase
GIY23_15175	COG1414	Transcriptional regulator
GIY23_15210	COG2226	methyltransferase
GIY23_15215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIY23_15215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIY23_15230	COG1597	lipid kinase activity
GIY23_15245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_15260	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_15295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIY23_15300	COG1793	dna ligase
GIY23_15320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIY23_15355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIY23_15365	COG1929	Belongs to the glycerate kinase type-1 family
GIY23_15370	COG0471	metal ion transport
GIY23_15375	COG0583	DNA-binding transcription factor activity
GIY23_15385	COG0596	Alpha beta hydrolase
GIY23_15400	COG0583	DNA-binding transcription factor activity
GIY23_15430	COG2826	transposase and inactivated derivatives, IS30 family
GIY23_15470	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_15480	COG0477	Major facilitator Superfamily
GIY23_15520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIY23_15525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GIY23_15535	COG0667	Aldo Keto reductase
GIY23_15540	COG5001	Diguanylate cyclase
GIY23_15590	COG0589	response to stress
GIY23_15605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GIY23_15615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GIY23_15640	COG1309	transcriptional regulator
GIY23_15645	COG1960	acyl-CoA dehydrogenase activity
GIY23_15660	COG1902	pentaerythritol trinitrate reductase activity
GIY23_15665	COG4221	oxidoreductase activity
GIY23_15670	COG0385	Bile acid
GIY23_15675	COG0514	ATP-dependent DNA helicase (RecQ)
GIY23_15690	COG0395	ABC-type sugar transport system, permease component
GIY23_15695	COG1063	alcohol dehydrogenase
GIY23_15700	COG1349	DNA-binding transcription factor activity
GIY23_15705	COG1063	alcohol dehydrogenase
GIY23_15710	COG1070	Carbohydrate kinase
GIY23_15715	COG3842	ATPase activity
GIY23_15725	COG2814	Major facilitator Superfamily
GIY23_15765	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_15770	COG0022	dehydrogenase e1 component
GIY23_15775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GIY23_15780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIY23_15800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_15800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIY23_15825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIY23_15835	COG0730	response to heat
GIY23_15840	COG2801	Transposase and inactivated derivatives
GIY23_15850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIY23_15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GIY23_15875	COG5564	TIM-barrel signal transduction protein
GIY23_15880	COG5441	Belongs to the UPF0261 family
GIY23_15910	COG1960	acyl-CoA dehydrogenase activity
GIY23_15920	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_15930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GIY23_15935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GIY23_15940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GIY23_15945	COG0586	Pfam SNARE associated Golgi protein
GIY23_15950	COG2027	D-alanyl-D-alanine carboxypeptidase
GIY23_15955	COG1280	lysine exporter protein (LysE YggA)
GIY23_15960	COG1522	sequence-specific DNA binding
GIY23_15965	COG1946	Acyl-CoA thioesterase
GIY23_16005	COG3973	AAA domain
GIY23_16020	COG0070	glutamate synthase
GIY23_16020	COG0067	glutamate synthase
GIY23_16020	COG0069	glutamate synthase activity
GIY23_16025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GIY23_16030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIY23_16035	COG1120	ATPase activity
GIY23_16040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GIY23_16055	COG0159	tryptophan synthase activity
GIY23_16060	COG0133	tryptophan synthase activity
GIY23_16065	COG0134	indole-3-glycerol-phosphate synthase activity
GIY23_16075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GIY23_16085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GIY23_16090	COG0107	imidazoleglycerol-phosphate synthase activity
GIY23_16100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GIY23_16110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GIY23_16120	COG3958	Transketolase
GIY23_16125	COG3959	Transketolase, thiamine diphosphate binding domain
GIY23_16135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIY23_16140	COG4565	transcriptional regulatory protein
GIY23_16145	COG3290	protein histidine kinase activity
GIY23_16150	COG1301	dicarboxylic acid transport
GIY23_16170	COG0131	Imidazoleglycerol-phosphate dehydratase
GIY23_16175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GIY23_16180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GIY23_16225	COG0444	Belongs to the ABC transporter superfamily
GIY23_16245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIY23_16265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GIY23_16295	COG2124	cytochrome p450
GIY23_16300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GIY23_16305	COG0587	DNA-directed DNA polymerase activity
GIY23_16335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GIY23_16345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GIY23_16355	COG3599	regulation of cell shape
GIY23_16365	COG1799	cell septum assembly
GIY23_16370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GIY23_16385	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_16395	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GIY23_16405	COG3469	chitinase activity
GIY23_16465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GIY23_16470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GIY23_16475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GIY23_16485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GIY23_16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GIY23_16500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GIY23_16505	COG0768	penicillin binding
GIY23_16515	COG0275	rRNA processing
GIY23_16520	COG2001	Belongs to the MraZ family
GIY23_16525	COG0714	Associated with various cellular activities
GIY23_16535	COG1305	Transglutaminase-like
GIY23_16550	COG1192	Involved in chromosome partitioning
GIY23_16555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GIY23_16560	COG2233	PERMEase
GIY23_16570	COG1842	Phage shock protein A
GIY23_16575	COG1396	sequence-specific DNA binding
GIY23_16580	COG1058	Belongs to the CinA family
GIY23_16580	COG1546	Belongs to the CinA family
GIY23_16590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIY23_16595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GIY23_16625	COG0596	Alpha beta hydrolase
GIY23_16635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GIY23_16640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIY23_16650	COG2815	serine threonine protein kinase
GIY23_16650	COG0515	serine threonine protein kinase
GIY23_16655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GIY23_16680	COG3214	Protein conserved in bacteria
GIY23_16705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GIY23_16710	COG0612	Peptidase, M16
GIY23_16715	COG1185	polyribonucleotide nucleotidyltransferase activity
GIY23_16720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GIY23_16750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GIY23_16765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GIY23_16770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GIY23_16780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GIY23_16795	COG0779	Required for maturation of 30S ribosomal subunits
GIY23_16820	COG0432	Pfam Uncharacterised protein family UPF0047
GIY23_16830	COG0442	prolyl-tRNA aminoacylation
GIY23_16840	COG3022	response to hydroperoxide
GIY23_16850	COG0513	Belongs to the DEAD box helicase family
GIY23_16885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIY23_16895	COG2367	Beta-lactamase
GIY23_16900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIY23_16900	COG1648	precorrin-2 dehydrogenase activity
GIY23_16945	COG1280	lysine exporter protein (LysE YggA)
GIY23_16955	COG1881	PFAM PEBP family protein
GIY23_16970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GIY23_16975	COG2807	transmembrane transport
GIY23_16990	COG1492	cobalamin metabolic process
GIY23_17010	COG1414	Transcriptional regulator
GIY23_17015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GIY23_17025	COG3485	protocatechuate 3,4-dioxygenase
GIY23_17045	COG0477	Major facilitator Superfamily
GIY23_17055	COG1960	acyl-CoA dehydrogenase activity
GIY23_17075	COG0183	Belongs to the thiolase family
GIY23_17080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GIY23_17090	COG0768	penicillin binding
GIY23_17105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GIY23_17110	COG0750	zinc metalloprotease
GIY23_17115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GIY23_17150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GIY23_17160	COG1121	(ABC) transporter
GIY23_17165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GIY23_17190	COG0233	cytoplasmic translational termination
GIY23_17195	COG0528	UMP kinase activity
GIY23_17200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GIY23_17205	COG0052	Belongs to the universal ribosomal protein uS2 family
GIY23_17215	COG1191	sigma factor activity
GIY23_17235	COG0792	nuclease activity
GIY23_17245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GIY23_17250	COG0681	Belongs to the peptidase S26 family
GIY23_17255	COG0335	large ribosomal subunit rRNA binding
GIY23_17260	COG0336	Belongs to the RNA methyltransferase TrmD family
GIY23_17265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GIY23_17275	COG0228	four-way junction DNA binding
GIY23_17315	COG2807	transmembrane transport
GIY23_17340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GIY23_17345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIY23_17360	COG4106	trans-aconitate 2-methyltransferase activity
GIY23_17365	COG2318	DinB family
GIY23_17375	COG1254	Belongs to the acylphosphatase family
GIY23_17390	COG1072	(Pantothenic acid kinase))
GIY23_17410	COG1072	(Pantothenic acid kinase))
GIY23_17415	COG2814	Major facilitator Superfamily
GIY23_17425	COG0367	asparagine synthase
GIY23_17430	COG0477	Major facilitator Superfamily
GIY23_17435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GIY23_17440	COG0571	ribonuclease III activity
GIY23_17445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GIY23_17465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GIY23_17470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GIY23_17475	COG0742	ribosomal rna small subunit methyltransferase
GIY23_17485	COG4585	Histidine kinase
GIY23_17500	COG1461	Dihydroxyacetone kinase
GIY23_17505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GIY23_17510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GIY23_17515	COG0477	Major facilitator Superfamily
GIY23_17540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIY23_17555	COG0626	cystathionine gamma-synthase activity
GIY23_17560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GIY23_17570	COG1920	GTP binding
GIY23_17580	COG0406	alpha-ribazole phosphatase activity
GIY23_17580	COG0494	nUDIX hydrolase
GIY23_17585	COG0776	regulation of translation
GIY23_17590	COG0066	3-isopropylmalate dehydratase activity
GIY23_17595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GIY23_17620	COG1011	Hydrolase
GIY23_17625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIY23_17635	COG0179	Fumarylacetoacetate (FAA) hydrolase
GIY23_17640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIY23_17645	COG0473	3-isopropylmalate dehydrogenase activity
GIY23_17650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIY23_17660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GIY23_17665	COG0440	acetolactate synthase activity
GIY23_17680	COG0129	dihydroxy-acid dehydratase activity
GIY23_17720	COG0154	amidase activity
GIY23_17725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GIY23_17750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GIY23_17770	COG0596	Alpha beta hydrolase
GIY23_17775	COG0482	sulfurtransferase activity
GIY23_17785	COG2814	Major facilitator Superfamily
GIY23_17790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GIY23_17805	COG0328	RNA-DNA hybrid ribonuclease activity
GIY23_17810	COG2072	flavoprotein involved in K transport
GIY23_17815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GIY23_17825	COG1307	EDD domain protein, DegV family
GIY23_17830	COG1643	Atp-dependent helicase
GIY23_17850	COG1119	ATPase activity
GIY23_17875	COG0058	SHG alpha-glucan phosphorylase activity
GIY23_17900	COG1846	Transcriptional regulator
GIY23_17935	COG0183	Belongs to the thiolase family
GIY23_17945	COG0346	lactoylglutathione lyase activity
GIY23_17965	COG0596	Alpha beta hydrolase
GIY23_17995	COG2376	Dihydroxyacetone kinase
GIY23_18020	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GIY23_18030	COG0494	nUDIX hydrolase
GIY23_18035	COG1280	lysine exporter protein (LysE YggA)
GIY23_18045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIY23_18045	COG0723	plastoquinol--plastocyanin reductase activity
GIY23_18070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GIY23_18075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GIY23_18080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GIY23_18085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GIY23_18090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GIY23_18095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GIY23_18100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GIY23_18105	COG0356	it plays a direct role in the translocation of protons across the membrane
GIY23_18115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GIY23_18125	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_18125	COG0596	Alpha beta hydrolase
GIY23_18135	COG2890	protein-(glutamine-N5) methyltransferase activity
GIY23_18140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GIY23_18145	COG0254	rRNA binding
GIY23_18155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GIY23_18160	COG0083	homoserine kinase activity
GIY23_18165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GIY23_18170	COG0460	homoserine dehydrogenase
GIY23_18175	COG0019	diaminopimelate decarboxylase activity
GIY23_18180	COG0018	arginyl-trna synthetase
GIY23_18195	COG0471	metal ion transport
GIY23_18220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIY23_18280	COG0582	viral genome integration into host DNA
GIY23_18300	COG2018	Roadblock/LC7 domain
GIY23_18325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIY23_18330	COG1566	PFAM secretion protein HlyD family protein
GIY23_18345	COG1309	transcriptional regulator
GIY23_18365	COG0183	Belongs to the thiolase family
GIY23_18370	COG0247	lactate metabolic process
GIY23_18375	COG0277	FAD linked oxidase domain protein
GIY23_18380	COG0277	FAD linked oxidase domain protein
GIY23_18395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GIY23_18420	COG0366	Alpha amylase catalytic
GIY23_18425	COG1760	l-serine dehydratase
GIY23_18430	COG0509	glycine decarboxylation via glycine cleavage system
GIY23_18435	COG0686	Belongs to the AlaDH PNT family
GIY23_18460	COG1132	(ABC) transporter
GIY23_18465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_18465	COG0567	Dehydrogenase, E1 component
GIY23_18475	COG1063	alcohol dehydrogenase
GIY23_18490	COG1228	amidohydrolase
GIY23_18495	COG0402	S-adenosylhomocysteine deaminase activity
GIY23_18505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GIY23_18510	COG2986	histidine ammonia-lyase
GIY23_18525	COG1174	glycine betaine transport
GIY23_18530	COG1174	glycine betaine transport
GIY23_18550	COG5001	Diguanylate cyclase
GIY23_18580	COG0406	alpha-ribazole phosphatase activity
GIY23_18600	COG1597	lipid kinase activity
GIY23_18615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GIY23_18630	COG1595	DNA-templated transcription, initiation
GIY23_18635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GIY23_18650	COG2135	peptidase activity
GIY23_18655	COG2135	peptidase activity
GIY23_18660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GIY23_18665	COG1162	GTPase activity
GIY23_18685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIY23_18705	COG1011	Hydrolase
GIY23_18715	COG0653	protein targeting
GIY23_18720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GIY23_18730	COG5401	PFAM Sporulation and spore germination
GIY23_18735	COG5002	protein histidine kinase activity
GIY23_18740	COG0745	RESPONSE REGULATOR receiver
GIY23_18755	COG0531	amino acid
GIY23_18760	COG1482	cell wall glycoprotein biosynthetic process
GIY23_18800	COG1994	Peptidase M50
GIY23_18810	COG0778	Nitroreductase
GIY23_18810	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GIY23_18835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GIY23_18850	COG0438	transferase activity, transferring glycosyl groups
GIY23_18855	COG0438	transferase activity, transferring glycosyl groups
GIY23_18890	COG0297	glycogen (starch) synthase activity
GIY23_18895	COG1091	dTDP-4-dehydrorhamnose reductase activity
GIY23_18905	COG1316	TRANSCRIPTIONal
GIY23_18910	COG1316	TRANSCRIPTIONal
GIY23_18955	COG2205	protein histidine kinase activity
GIY23_18965	COG0483	inositol monophosphate 1-phosphatase activity
GIY23_19055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GIY23_19065	COG0424	maF-like protein
GIY23_19070	COG1301	dicarboxylic acid transport
GIY23_19075	COG4770	biotin carboxylase activity
GIY23_19115	COG0277	FAD linked oxidase domain protein
GIY23_19135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GIY23_19140	COG1349	DNA-binding transcription factor activity
GIY23_19145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GIY23_19150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GIY23_19190	COG1473	amidohydrolase
GIY23_19190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GIY23_19205	COG1320	monovalent cation:proton antiporter activity
GIY23_19220	COG0651	ATP synthesis coupled electron transport
GIY23_19225	COG1006	Multisubunit Na H antiporter MnhC subunit
GIY23_19230	COG2111	Na H antiporter
GIY23_19235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GIY23_19235	COG2111	Na H antiporter
GIY23_19250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GIY23_19290	COG3844	kynureninase activity
GIY23_19300	COG3483	tryptophan 2,3-dioxygenase activity
GIY23_19305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GIY23_19310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GIY23_19315	COG1012	belongs to the aldehyde dehydrogenase family
GIY23_19335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIY23_19355	COG1079	Belongs to the binding-protein-dependent transport system permease family
GIY23_19365	COG3845	ABC transporter
GIY23_19370	COG1744	ABC transporter substrate-binding protein PnrA-like
GIY23_19380	COG2009	succinate dehydrogenase
GIY23_19405	COG1686	Belongs to the peptidase S11 family
GIY23_19410	COG1295	ribonuclease BN
GIY23_19415	COG0180	Tryptophanyl-tRNA synthetase
GIY23_19430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GIY23_19435	COG1404	Belongs to the peptidase S8 family
GIY23_19465	COG2826	transposase and inactivated derivatives, IS30 family
GIY23_19470	COG0708	Exodeoxyribonuclease III
GIY23_19475	COG2339	peptidase activity
GIY23_19480	COG1414	Transcriptional regulator
GIY23_19485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GIY23_19490	COG3485	protocatechuate 3,4-dioxygenase
GIY23_19495	COG3485	protocatechuate 3,4-dioxygenase
GIY23_19505	COG2084	Dehydrogenase
GIY23_19540	COG0471	metal ion transport
GIY23_19560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIY23_19575	COG2814	Major facilitator Superfamily
GIY23_19615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GIY23_19635	COG1357	PFAM Pentapeptide repeats (8 copies)
GIY23_19645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIY23_19660	COG0587	DNA-directed DNA polymerase activity
GIY23_19700	COG0045	succinate-CoA ligase (ADP-forming) activity
GIY23_19710	COG0739	heme binding
GIY23_19725	COG0586	Pfam SNARE associated Golgi protein
GIY23_19740	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_19775	COG0583	DNA-binding transcription factor activity
GIY23_19790	COG1324	tolerance protein
GIY23_19815	COG0519	Catalyzes the synthesis of GMP from XMP
GIY23_19815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GIY23_19825	COG0516	GMP reductase activity
GIY23_19865	COG0459	protein refolding
GIY23_19870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GIY23_19875	COG3540	Alkaline phosphatase
GIY23_19880	COG3540	Alkaline phosphatase
GIY23_19895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GIY23_19900	COG0456	acetyltransferase
GIY23_19910	COG1929	Belongs to the glycerate kinase type-1 family
GIY23_19915	COG0579	oxidoreductase
GIY23_19940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GIY23_19945	COG1414	Transcriptional regulator
GIY23_19950	COG0802	atpase or kinase
GIY23_19995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GIY23_20000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GIY23_20005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GIY23_20020	COG0443	Heat shock 70 kDa protein
GIY23_20025	COG1674	ftsk spoiiie
GIY23_20035	COG1404	Belongs to the peptidase S8 family
GIY23_20065	COG0101	tRNA pseudouridine synthase activity
GIY23_20070	COG0203	ribosomal protein L17
GIY23_20075	COG0202	RNA polymerase activity
GIY23_20080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GIY23_20085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GIY23_20090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GIY23_20095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GIY23_20100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GIY23_20105	COG3963	phosphatidate phosphatase activity
GIY23_20115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GIY23_20125	COG0563	adenylate kinase activity
GIY23_20135	COG0200	Binds to the 23S rRNA
GIY23_20140	COG1841	ribosomal large subunit assembly
GIY23_20145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GIY23_20150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GIY23_20155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GIY23_20160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GIY23_20165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GIY23_20170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GIY23_20175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GIY23_20180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GIY23_20185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GIY23_20190	COG0255	Belongs to the universal ribosomal protein uL29 family
GIY23_20195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GIY23_20200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GIY23_20205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GIY23_20210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GIY23_20215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GIY23_20220	COG0089	rRNA binding
GIY23_20225	COG0088	Forms part of the polypeptide exit tunnel
GIY23_20230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GIY23_20235	COG0051	transcription antitermination factor activity, RNA binding
GIY23_20240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GIY23_20245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GIY23_20250	COG0049	tRNA binding
GIY23_20255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GIY23_20290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GIY23_20295	COG0085	RNA polymerase activity
GIY23_20320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GIY23_20345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GIY23_20355	COG1127	ABC transporter
GIY23_20360	COG0222	ribosome binding
GIY23_20365	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GIY23_20375	COG0081	regulation of translation
GIY23_20380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GIY23_20400	COG0436	Aminotransferase
GIY23_20410	COG2030	dehydratase
GIY23_20415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GIY23_20450	COG2018	Roadblock/LC7 domain
GIY23_20465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIY23_20495	COG1366	Belongs to the anti-sigma-factor antagonist family
GIY23_20510	COG2080	2 iron, 2 sulfur cluster binding
GIY23_20515	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIY23_20520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIY23_20530	COG1620	l-lactate permease
GIY23_20540	COG0067	glutamate synthase
GIY23_20540	COG0070	glutamate synthase
GIY23_20540	COG0069	glutamate synthase activity
GIY23_20595	COG1401	restriction endodeoxyribonuclease activity
GIY23_20600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GIY23_20605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIY23_20610	COG1111	helicase
GIY23_20610	COG1205	dead DEAH box helicase
GIY23_20650	COG1674	ftsk spoiiie
GIY23_20700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GIY23_20710	COG1834	amidinotransferase
GIY23_20715	COG1522	sequence-specific DNA binding
GIY23_20725	COG0142	geranyltranstransferase activity
GIY23_20730	COG1007	ATP synthesis coupled electron transport
GIY23_20745	COG0713	ATP synthesis coupled electron transport
GIY23_20750	COG0839	Belongs to the complex I subunit 6 family
GIY23_20755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIY23_20760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GIY23_20765	COG1034	ATP synthesis coupled electron transport
GIY23_20780	COG0649	NAD binding
GIY23_20785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIY23_20790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIY23_20805	COG2226	methyltransferase
GIY23_20835	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GIY23_20840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GIY23_20860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIY23_20885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIY23_20895	COG0785	Cytochrome C biogenesis protein
GIY23_20905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIY23_20910	COG0406	alpha-ribazole phosphatase activity
GIY23_20915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GIY23_20960	COG0181	hydroxymethylbilane synthase activity
GIY23_20965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GIY23_20970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GIY23_20980	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_21015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GIY23_21020	COG0318	PFAM AMP-dependent synthetase and ligase
GIY23_21030	COG1082	Xylose isomerase domain protein TIM barrel
GIY23_21050	COG5002	protein histidine kinase activity
GIY23_21065	COG0438	transferase activity, transferring glycosyl groups
GIY23_21080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GIY23_21155	COG2733	membrane
GIY23_21195	COG2364	Membrane
GIY23_21200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GIY23_21205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIY23_21215	COG2826	transposase and inactivated derivatives, IS30 family
GIY23_21265	COG1960	acyl-CoA dehydrogenase activity
GIY23_21275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GIY23_21295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GIY23_21305	COG2814	Major facilitator Superfamily
GIY23_21310	COG0656	L-ascorbic acid biosynthetic process
GIY23_21345	COG0656	L-ascorbic acid biosynthetic process
GIY23_21350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIY23_21360	COG1739	Uncharacterized protein family UPF0029
GIY23_21375	COG1309	transcriptional regulator
GIY23_21425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GIY23_21430	COG2188	Transcriptional regulator
GIY23_21480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GIY23_21500	COG0456	acetyltransferase
GIY23_21505	COG0745	RESPONSE REGULATOR receiver
GIY23_21540	COG4044	May play a role in the intracellular transport of hydrophobic ligands
GIY23_21555	COG0354	folic acid binding
GIY23_21585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GIY23_21620	COG3387	PFAM Glycoside hydrolase 15-related
GIY23_21625	COG1063	alcohol dehydrogenase
GIY23_21650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GIY23_21655	COG0047	phosphoribosylformylglycinamidine synthase activity
GIY23_21660	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GIY23_21670	COG1234	tRNA 3'-trailer cleavage
GIY23_21675	COG2337	Toxic component of a toxin-antitoxin (TA) module
GIY23_21690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GIY23_21700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GIY23_21705	COG1132	(ABC) transporter
GIY23_21710	COG1132	(ABC) transporter
GIY23_21725	COG1595	DNA-templated transcription, initiation
GIY23_21735	COG0436	Aminotransferase
GIY23_21740	COG3953	SLT domain
GIY23_21740	COG5280	Phage tail tape measure protein TP901
GIY23_21755	COG0584	glycerophosphoryl diester phosphodiesterase
GIY23_21760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GIY23_21785	COG4129	membrane
GIY23_21805	COG1595	DNA-templated transcription, initiation
GIY23_21810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GIY23_21820	COG0586	Pfam SNARE associated Golgi protein
GIY23_21825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIY23_21835	COG0300	oxidoreductase activity
GIY23_21845	COG2814	Major facilitator Superfamily
GIY23_21850	COG0542	response to heat
GIY23_21855	COG1115	amino acid carrier protein
GIY23_21860	COG2814	Major facilitator Superfamily
GIY23_21890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GIY23_21895	COG0789	Transcriptional regulator
GIY23_21900	COG0484	heat shock protein binding
GIY23_21905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GIY23_21910	COG0443	Heat shock 70 kDa protein
GIY23_21940	COG2181	nitrate reductase activity
GIY23_21940	COG0247	lactate metabolic process
GIY23_21950	COG0477	Major facilitator Superfamily
GIY23_21955	COG0717	Belongs to the dCTP deaminase family
GIY23_22000	COG5416	Lipopolysaccharide assembly protein A domain
GIY23_22005	COG1742	UPF0060 membrane protein
GIY23_22015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIY23_22040	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_22045	COG0402	S-adenosylhomocysteine deaminase activity
GIY23_22050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GIY23_22060	COG0589	response to stress
GIY23_22075	COG0560	Phosphoserine phosphatase
GIY23_22075	COG3830	Belongs to the UPF0237 family
GIY23_22085	COG2197	response regulator
GIY23_22090	COG4585	Histidine kinase
GIY23_22105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GIY23_22120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GIY23_22145	COG0765	amino acid transport
GIY23_22155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIY23_22165	COG0022	dehydrogenase e1 component
GIY23_22170	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIY23_22185	COG1309	transcriptional regulator
GIY23_22195	COG1028	Short-chain dehydrogenase reductase Sdr
GIY23_22200	COG0183	Belongs to the thiolase family
GIY23_22235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GIY23_22250	COG1960	acyl-CoA dehydrogenase activity
GIY23_22270	COG0305	Participates in initiation and elongation during chromosome replication
GIY23_22275	COG0359	binds to the 23S rRNA
GIY23_22280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GIY23_22290	COG0360	Binds together with S18 to 16S ribosomal RNA
GIY23_22315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIY23_22325	COG1695	Transcriptional regulator
GIY23_22365	COG2205	protein histidine kinase activity
GIY23_22370	COG2197	response regulator
GIY23_22375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIY23_22410	COG0495	leucyl-tRNA aminoacylation
GIY23_22435	COG1678	Uncharacterized ACR, COG1678
GIY23_22440	COG0617	tRNA 3'-terminal CCA addition
GIY23_22465	COG1595	DNA-templated transcription, initiation
GIY23_22480	COG3118	belongs to the thioredoxin family
GIY23_22480	COG0492	ferredoxin-NADP+ reductase activity
GIY23_22485	COG0860	N-Acetylmuramoyl-L-alanine amidase
GIY23_22485	COG3409	Peptidoglycan-binding domain 1 protein
GIY23_22500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIY23_22505	COG1181	Belongs to the D-alanine--D-alanine ligase family
GIY23_22515	COG1192	Involved in chromosome partitioning
GIY23_22520	COG0357	Ribosomal RNA small subunit methyltransferase G
GIY23_22535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GIY23_22540	COG0594	ribonuclease P activity
GIY23_22545	COG0230	Belongs to the bacterial ribosomal protein bL34 family