locus-tag	class	description
H6845_00015	COG0629	single-stranded DNA binding
H6845_00030	COG0772	Belongs to the SEDS family
H6845_00040	COG1187	pseudouridine synthase activity
H6845_00050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H6845_00060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H6845_00075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6845_00080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H6845_00110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H6845_00125	COG0154	amidase activity
H6845_00130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H6845_00145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6845_00150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H6845_00155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H6845_00170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H6845_00190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H6845_00195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H6845_00200	COG0492	ferredoxin-NADP+ reductase activity
H6845_00210	COG0360	Binds together with S18 to 16S ribosomal RNA
H6845_00220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6845_00220	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H6845_00225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H6845_00230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6845_00265	COG0124	histidyl-tRNA synthetase
H6845_00270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H6845_00280	COG0215	cysteine-tRNA ligase activity
H6845_00285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H6845_00290	COG4591	ABC-type transport system involved in lipoprotein release permease component
H6845_00295	COG1136	(ABC) transporter
H6845_00330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H6845_00345	COG2003	Belongs to the UPF0758 family
H6845_00350	COG0024	Methionine aminopeptidase
H6845_00365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H6845_00370	COG0717	Belongs to the dCTP deaminase family
H6845_00390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H6845_00405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6845_00455	COG0101	tRNA pseudouridine synthase activity
H6845_00470	COG0564	pseudouridine synthase activity
H6845_00500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H6845_00505	COG0222	ribosome binding
H6845_00510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H6845_00515	COG0081	regulation of translation
H6845_00520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H6845_00525	COG0250	Participates in transcription elongation, termination and antitermination
H6845_00560	COG1122	ATPase activity
H6845_00565	COG0477	Major facilitator Superfamily
H6845_00570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6845_00630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H6845_00640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H6845_00645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6845_00650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H6845_00655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H6845_00670	COG0194	GDP metabolic process
H6845_00675	COG0193	aminoacyl-tRNA hydrolase activity
H6845_00680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H6845_00690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H6845_00695	COG0653	protein targeting
H6845_00720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6845_00745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H6845_00750	COG2894	cell division
H6845_00755	COG3202	ADP transmembrane transporter activity
H6845_00760	COG0606	chelatase, subunit chli
H6845_00770	COG3202	ADP transmembrane transporter activity
H6845_00790	COG0822	iron-sulfur transferase activity
H6845_00795	COG1104	cysteine desulfurase activity
H6845_00800	COG2945	thiolester hydrolase activity
H6845_00805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6845_00810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H6845_00825	COG0330	HflC and HflK could
H6845_00830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H6845_00835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H6845_00865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H6845_00885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H6845_00895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H6845_00900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H6845_00910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H6845_00920	COG0525	valine-tRNA ligase activity
H6845_00930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H6845_00945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6845_00960	COG1160	GTP binding
H6845_00985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H6845_01005	COG0571	ribonuclease III activity
H6845_01010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H6845_01015	COG0009	L-threonylcarbamoyladenylate synthase
H6845_01020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H6845_01025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6845_01030	COG0084	hydrolase, TatD family'
H6845_01035	COG0617	tRNA 3'-terminal CCA addition
H6845_01040	COG0504	CTP synthase activity
H6845_01055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H6845_01070	COG0750	zinc metalloprotease
H6845_01075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6845_01095	COG0328	RNA-DNA hybrid ribonuclease activity
H6845_01100	COG0792	nuclease activity
H6845_01105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H6845_01120	COG0633	Ferredoxin
H6845_01125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H6845_01135	COG0356	it plays a direct role in the translocation of protons across the membrane
H6845_01170	COG2239	Acts as a magnesium transporter
H6845_01175	COG0280	phosphate acetyltransferase
H6845_01175	COG0281	malic enzyme
H6845_01180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6845_01190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H6845_01195	COG0228	four-way junction DNA binding
H6845_01200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6845_01210	COG0670	Belongs to the BI1 family
H6845_01220	COG0336	Belongs to the RNA methyltransferase TrmD family
H6845_01225	COG0335	large ribosomal subunit rRNA binding
H6845_01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H6845_01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6845_01250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H6845_01255	COG0088	Forms part of the polypeptide exit tunnel
H6845_01265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H6845_01270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H6845_01280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H6845_01285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H6845_01305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H6845_01310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H6845_01315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H6845_01325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H6845_01330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H6845_01335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H6845_01340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H6845_01345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H6845_01365	COG0201	protein transport
H6845_01370	COG0563	adenylate kinase activity
H6845_01375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H6845_01380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H6845_01385	COG0202	RNA polymerase activity
H6845_01410	COG3852	Histidine kinase
H6845_01425	COG0492	ferredoxin-NADP+ reductase activity
H6845_01440	COG0495	leucyl-tRNA aminoacylation
H6845_01455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H6845_01460	COG0217	transcriptional regulatory protein
H6845_01465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H6845_01470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H6845_01475	COG0359	binds to the 23S rRNA
H6845_01480	COG0305	Participates in initiation and elongation during chromosome replication
H6845_01490	COG4957	zinc ion binding
H6845_01500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H6845_01505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6845_01525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H6845_01535	COG2890	protein-(glutamine-N5) methyltransferase activity
H6845_01540	COG0531	amino acid
H6845_01545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H6845_01550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H6845_01555	COG1185	polyribonucleotide nucleotidyltransferase activity
H6845_01580	COG1674	ftsk spoiiie
H6845_01610	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6845_01625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6845_01640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H6845_01645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H6845_01650	COG2171	N-acyltransferase activity
H6845_01660	COG0616	signal peptide processing
H6845_01665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6845_01670	COG0450	alkyl hydroperoxide reductase
H6845_01675	COG0728	peptidoglycan biosynthetic process
H6845_01680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H6845_01695	COG0594	ribonuclease P activity
H6845_01710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H6845_01755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6845_01760	COG0052	Belongs to the universal ribosomal protein uS2 family
H6845_01765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H6845_01770	COG0528	UMP kinase activity
H6845_01775	COG1040	competence protein
H6845_01780	COG0149	triose-phosphate isomerase activity
H6845_01785	COG0233	cytoplasmic translational termination
H6845_01790	COG0739	heme binding
H6845_01795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H6845_01800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H6845_01805	COG0443	Heat shock 70 kDa protein
H6845_01815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H6845_01820	COG0358	DNA primase activity
H6845_01830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H6845_01840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H6845_01855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H6845_01860	COG0537	adenosine 5'-monophosphoramidase activity
H6845_01865	COG0658	competence protein
H6845_01865	COG2333	competence protein COMEC
H6845_01875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H6845_01885	COG0501	Belongs to the peptidase M48B family
H6845_01890	COG0802	atpase or kinase
H6845_01905	COG0768	penicillin binding
H6845_01915	COG0275	rRNA processing
H6845_01920	COG2001	Belongs to the MraZ family
H6845_01925	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H6845_01935	COG0210	DNA helicase
H6845_01940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H6845_01945	COG0531	amino acid
H6845_01955	COG0736	holo-[acyl-carrier-protein] synthase activity
H6845_01960	COG0482	sulfurtransferase activity
H6845_01995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H6845_02000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H6845_02040	COG0195	Participates in both transcription termination and antitermination
H6845_02040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H6845_02065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H6845_02130	COG0590	tRNA wobble adenosine to inosine editing
H6845_02145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H6845_02165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H6845_02170	COG1028	Short-chain dehydrogenase reductase Sdr
H6845_02195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H6845_02200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H6845_02205	COG0459	protein refolding
H6845_02210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6845_02215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6845_02220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6845_02220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6845_02225	COG0751	glycine-tRNA ligase activity
H6845_02230	COG0752	glycyl-tRNA synthetase alpha subunit
H6845_02245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6845_02250	COG0758	DNA mediated transformation
H6845_02255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H6845_02265	COG0442	prolyl-tRNA aminoacylation
H6845_02270	COG0415	Belongs to the DNA photolyase family
H6845_02285	COG0698	ribose 5-phosphate isomerase
H6845_02290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H6845_02295	COG4974	Belongs to the 'phage' integrase family
H6845_02300	COG0825	malonyl-CoA metabolic process
H6845_02340	COG3202	ADP transmembrane transporter activity
H6845_02355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H6845_02360	COG0481	GTPase activity
H6845_02365	COG0072	phenylalanine-tRNA ligase activity
H6845_02365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6845_02370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H6845_02375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H6845_02385	COG3118	belongs to the thioredoxin family
H6845_02390	COG0012	GTP binding
H6845_02410	COG0688	phosphatidylethanolamine metabolic process
H6845_02415	COG0688	phosphatidylethanolamine metabolic process
H6845_02420	COG1722	exodeoxyribonuclease VII activity
H6845_02440	COG4695	Portal protein
H6845_02490	COG0527	aspartate kinase activity
H6845_02495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6845_02510	COG1475	DNA binding
H6845_02520	COG0357	Ribosomal RNA small subunit methyltransferase G
H6845_02530	COG1570	exodeoxyribonuclease VII activity
H6845_02535	COG1530	ribonuclease E activity
H6845_02560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H6845_02570	COG0519	Catalyzes the synthesis of GMP from XMP
H6845_02595	COG0740	serine-type endopeptidase activity
H6845_02600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6845_02605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H6845_02610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H6845_02620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6845_02630	COG0793	Belongs to the peptidase S41A family
H6845_02630	COG4946	Tricorn protease homolog
H6845_02640	COG0439	Biotin carboxylase
H6845_02655	COG0592	DNA-directed DNA polymerase activity
H6845_02665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H6845_02690	COG1132	(ABC) transporter
H6845_02695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H6845_02705	COG0483	inositol monophosphate 1-phosphatase activity
H6845_02710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6845_02720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6845_02735	COG4974	Belongs to the 'phage' integrase family
H6845_02740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6845_02750	COG3963	phosphatidate phosphatase activity
H6845_02770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine