locus-tag	class	description
H6850_00015	COG1923	regulation of RNA biosynthetic process
H6850_00025	COG1678	Uncharacterized ACR, COG1678
H6850_00030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H6850_00035	COG0617	tRNA 3'-terminal CCA addition
H6850_00050	COG0706	membrane insertase activity
H6850_00060	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H6850_00065	COG3842	ATPase activity
H6850_00070	COG0488	(ABC) transporter
H6850_00080	COG0202	RNA polymerase activity
H6850_00085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H6850_00090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H6850_00095	COG0563	adenylate kinase activity
H6850_00100	COG0201	protein transport
H6850_00105	COG0200	Binds to the 23S rRNA
H6850_00115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H6850_00120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H6850_00125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H6850_00130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H6850_00135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H6850_00140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H6850_00145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H6850_00150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H6850_00155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H6850_00165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H6850_00170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H6850_00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H6850_00180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H6850_00190	COG0089	rRNA binding
H6850_00195	COG0088	Forms part of the polypeptide exit tunnel
H6850_00200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H6850_00205	COG0051	transcription antitermination factor activity, RNA binding
H6850_00225	COG0590	tRNA wobble adenosine to inosine editing
H6850_00230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H6850_00250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H6850_00255	COG4122	O-methyltransferase activity
H6850_00265	COG0658	competence protein
H6850_00265	COG2333	competence protein COMEC
H6850_00300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H6850_00310	COG0012	GTP binding
H6850_00315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H6850_00325	COG1183	phosphatidylcholine synthase activity
H6850_00335	COG2884	Cell division ATP-binding protein ftsE
H6850_00340	COG0539	negative regulation of cytoplasmic translation
H6850_00345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H6850_00355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H6850_00365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H6850_00395	COG0504	CTP synthase activity
H6850_00410	COG0592	DNA-directed DNA polymerase activity
H6850_00430	COG4172	Belongs to the ABC transporter superfamily
H6850_00445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H6850_00455	COG0443	Heat shock 70 kDa protein
H6850_00465	COG0442	prolyl-tRNA aminoacylation
H6850_00470	COG3750	Belongs to the UPF0335 family
H6850_00490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H6850_00500	COG1496	oxidoreductase activity
H6850_00520	COG1570	exodeoxyribonuclease VII activity
H6850_00555	COG1722	exodeoxyribonuclease VII activity
H6850_00590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H6850_00595	COG0228	four-way junction DNA binding
H6850_00615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H6850_00620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6850_00640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6850_00660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H6850_00670	COG2814	Major facilitator Superfamily
H6850_00675	COG1217	gtp-binding protein TYPA
H6850_00695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H6850_00705	COG0406	alpha-ribazole phosphatase activity
H6850_00715	COG0456	acetyltransferase
H6850_00715	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H6850_00730	COG3475	LICD family
H6850_00735	COG1213	nucleotidyl transferase
H6850_00740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H6850_00745	COG0594	ribonuclease P activity
H6850_00760	COG0659	secondary active sulfate transmembrane transporter activity
H6850_00770	COG0802	atpase or kinase
H6850_00775	COG0705	Rhomboid family
H6850_00775	COG0457	Tetratricopeptide repeat
H6850_00790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H6850_00795	COG0194	GDP metabolic process
H6850_00805	COG0698	ribose 5-phosphate isomerase
H6850_00810	COG0586	Pfam SNARE associated Golgi protein
H6850_00815	COG4589	Belongs to the CDS family
H6850_00820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H6850_00825	COG1114	Component of the transport system for branched-chain amino acids
H6850_00845	COG0765	amino acid transport
H6850_00850	COG1126	abc transporter atp-binding protein
H6850_00870	COG4120	Belongs to the binding-protein-dependent transport system permease family
H6850_00875	COG2984	ABC transporter substrate binding protein
H6850_00880	COG0193	aminoacyl-tRNA hydrolase activity
H6850_00885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H6850_00915	COG0814	amino acid
H6850_00920	COG0126	phosphoglycerate kinase activity
H6850_00925	COG0606	chelatase, subunit chli
H6850_00940	COG0758	DNA mediated transformation
H6850_00985	COG0527	aspartate kinase activity
H6850_00995	COG3655	Transcriptional regulator
H6850_01005	COG0752	glycyl-tRNA synthetase alpha subunit
H6850_01015	COG0471	metal ion transport
H6850_01060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H6850_01085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6850_01130	COG1121	(ABC) transporter
H6850_01150	COG0415	Belongs to the DNA photolyase family
H6850_01195	COG0037	tRNA processing
H6850_01205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H6850_01225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H6850_01230	COG1160	GTP binding
H6850_01245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H6850_01255	COG0268	Binds directly to 16S ribosomal RNA
H6850_01260	COG0492	ferredoxin-NADP+ reductase activity
H6850_01270	COG0124	histidyl-tRNA synthetase
H6850_01295	COG0316	Belongs to the HesB IscA family
H6850_01300	COG0515	serine threonine protein kinase
H6850_01300	COG1357	PFAM Pentapeptide repeats (8 copies)
H6850_01330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H6850_01335	COG0724	RNA recognition motif
H6850_01340	COG0544	peptidyl-prolyl cis-trans isomerase activity
H6850_01365	COG0305	Participates in initiation and elongation during chromosome replication
H6850_01370	COG1686	Belongs to the peptidase S11 family
H6850_01375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H6850_01385	COG1253	flavin adenine dinucleotide binding
H6850_01400	COG0149	triose-phosphate isomerase activity
H6850_01425	COG2255	four-way junction helicase activity
H6850_01430	COG0772	Belongs to the SEDS family
H6850_01460	COG1846	Transcriptional regulator
H6850_01520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H6850_01550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H6850_01565	COG0210	DNA helicase
H6850_01570	COG0254	rRNA binding
H6850_01585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H6850_01625	COG0515	serine threonine protein kinase
H6850_01625	COG2815	serine threonine protein kinase
H6850_01630	COG1253	flavin adenine dinucleotide binding
H6850_01635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H6850_01675	COG4695	Portal protein
H6850_01705	COG2827	Endonuclease containing a URI domain
H6850_01710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H6850_01735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H6850_01860	COG2096	Adenosyltransferase
H6850_01865	COG2801	Transposase and inactivated derivatives
H6850_01865	COG3415	Transposase
H6850_01870	COG1132	(ABC) transporter
H6850_01895	COG0670	Belongs to the BI1 family
H6850_01910	COG0477	Major facilitator Superfamily
H6850_01935	COG1758	RNA polymerase activity
H6850_01945	COG0024	Methionine aminopeptidase
H6850_01955	COG1459	type II secretion system
H6850_01975	COG1104	cysteine desulfurase activity
H6850_01980	COG0811	peptide transport
H6850_02010	COG4974	Belongs to the 'phage' integrase family
H6850_02015	COG0281	malic enzyme
H6850_02055	COG0343	queuine tRNA-ribosyltransferase activity
H6850_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H6850_02095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H6850_02100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H6850_02125	COG0481	GTPase activity
H6850_02135	COG1322	Protein conserved in bacteria
H6850_02140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H6850_02150	COG1194	a g-specific adenine glycosylase
H6850_02175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H6850_02180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H6850_02185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H6850_02190	COG1192	Involved in chromosome partitioning
H6850_02210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H6850_02230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H6850_02255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H6850_02275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H6850_02295	COG0629	single-stranded DNA binding
H6850_02300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H6850_02315	COG1054	Belongs to the UPF0176 family
H6850_02335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H6850_02345	COG2771	luxR family
H6850_02350	COG0358	DNA primase activity
H6850_02380	COG0632	four-way junction helicase activity
H6850_02400	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H6850_02405	COG0742	ribosomal rna small subunit methyltransferase
H6850_02425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H6850_02435	COG2771	luxR family
H6850_02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H6850_02445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H6850_02450	COG0105	UTP biosynthetic process
H6850_02460	COG0248	Ppx GppA phosphatase
H6850_02460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H6850_02485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H6850_02505	COG2271	Major facilitator Superfamily
H6850_02520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H6850_02555	COG0756	dUTP diphosphatase activity
H6850_02565	COG1104	cysteine desulfurase activity
H6850_02585	COG0450	alkyl hydroperoxide reductase
H6850_02590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H6850_02635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H6850_02645	COG1136	(ABC) transporter
H6850_02665	COG3118	belongs to the thioredoxin family
H6850_02685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H6850_02710	COG0477	Major facilitator Superfamily
H6850_02725	COG0697	spore germination
H6850_02735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H6850_02740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H6850_02745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H6850_02780	COG0525	valine-tRNA ligase activity
H6850_02815	COG1475	DNA binding
H6850_02850	COG0242	peptide deformylase activity
H6850_02855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H6850_02870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H6850_02890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6850_02900	COG0556	nucleotide-excision repair
H6850_02920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H6850_02925	COG0779	Required for maturation of 30S ribosomal subunits
H6850_02930	COG0195	Participates in both transcription termination and antitermination
H6850_02930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H6850_02935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H6850_02940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H6850_02965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H6850_02970	COG1040	competence protein
H6850_02975	COG1177	transmembrane transport
H6850_02980	COG1176	ABC-type spermidine putrescine transport system, permease component I
H6850_03025	COG4957	zinc ion binding
H6850_03030	COG3128	pkhd-type hydroxylase
H6850_03035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H6850_03045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H6850_03050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H6850_03075	COG0488	(ABC) transporter
H6850_03085	COG1132	(ABC) transporter
H6850_03090	COG1132	(ABC) transporter
H6850_03115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H6850_03120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H6850_03125	COG3202	ADP transmembrane transporter activity
H6850_03135	COG0354	folic acid binding
H6850_03150	COG0728	peptidoglycan biosynthetic process
H6850_03155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H6850_03200	COG4174	ABC transporter (Permease)
H6850_03210	COG0792	nuclease activity
H6850_03215	COG0275	rRNA processing
H6850_03225	COG0768	penicillin binding
H6850_03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H6850_03260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H6850_03265	COG0081	regulation of translation
H6850_03270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H6850_03275	COG0222	ribosome binding
H6850_03280	COG0085	RNA polymerase activity
H6850_03285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H6850_03290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H6850_03300	COG0789	Transcriptional regulator
H6850_03305	COG0784	Response regulator, receiver
H6850_03345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H6850_03370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H6850_03375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H6850_03380	COG0822	iron-sulfur transferase activity
H6850_03385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H6850_03395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H6850_03400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H6850_03430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H6850_03435	COG0154	amidase activity
H6850_03440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H6850_03470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6850_03480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H6850_03500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H6850_03505	COG0009	L-threonylcarbamoyladenylate synthase
H6850_03510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H6850_03550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H6850_03555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H6850_03575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H6850_03600	COG0488	(ABC) transporter
H6850_03605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H6850_03625	COG2890	protein-(glutamine-N5) methyltransferase activity
H6850_03660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H6850_03680	COG0330	HflC and HflK could
H6850_03690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H6850_03695	COG4251	negative regulation of phosphorylation
H6850_03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6850_03705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H6850_03755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H6850_03760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H6850_03765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H6850_03780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H6850_03785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H6850_03790	COG0612	Peptidase, M16
H6850_03795	COG0612	Peptidase, M16
H6850_03805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6850_03810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H6850_03815	COG1187	pseudouridine synthase activity
H6850_03830	COG0360	Binds together with S18 to 16S ribosomal RNA
H6850_03835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H6850_03840	COG0322	excinuclease ABC activity
H6850_03845	COG0552	protein localization to endoplasmic reticulum
H6850_03850	COG0792	nuclease activity
H6850_03855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H6850_03860	COG0494	nUDIX hydrolase
H6850_03875	COG0531	amino acid
H6850_03880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H6850_03900	COG1968	undecaprenyl-diphosphatase activity
H6850_03920	COG0166	Belongs to the GPI family
H6850_03955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H6850_03965	COG0215	cysteine-tRNA ligase activity
H6850_03970	COG2945	thiolester hydrolase activity
H6850_03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H6850_04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H6850_04035	COG0482	sulfurtransferase activity
H6850_04050	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H6850_04055	COG0483	inositol monophosphate 1-phosphatase activity
H6850_04060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H6850_04070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H6850_04080	COG0768	penicillin binding
H6850_04100	COG4120	Belongs to the binding-protein-dependent transport system permease family
H6850_04105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H6850_04110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H6850_04175	COG0233	cytoplasmic translational termination
H6850_04180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H6850_04185	COG0052	Belongs to the universal ribosomal protein uS2 family
H6850_04195	COG0717	Belongs to the dCTP deaminase family
H6850_04210	COG0793	Belongs to the peptidase S41A family
H6850_04220	COG0492	ferredoxin-NADP+ reductase activity
H6850_04225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H6850_04230	COG1181	Belongs to the D-alanine--D-alanine ligase family
H6850_04240	COG0328	RNA-DNA hybrid ribonuclease activity
H6850_04250	COG1573	uracil-dna glycosylase
H6850_04255	COG0084	hydrolase, TatD family'
H6850_04260	COG0316	Belongs to the HesB IscA family
H6850_04265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H6850_04275	COG1674	ftsk spoiiie
H6850_04285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H6850_04295	COG0217	transcriptional regulatory protein
H6850_04325	COG0477	Major facilitator Superfamily
H6850_04330	COG1132	(ABC) transporter
H6850_04365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H6850_04375	COG1131	(ABC) transporter
H6850_04390	COG0101	tRNA pseudouridine synthase activity
H6850_04430	COG0459	protein refolding
H6850_04435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H6850_04450	COG0471	metal ion transport
H6850_04465	COG0205	6-phosphofructokinase activity
H6850_04485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H6850_04495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H6850_04505	COG0616	signal peptide processing
H6850_04510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H6850_04515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H6850_04520	COG0717	Belongs to the dCTP deaminase family
H6850_04525	COG0359	binds to the 23S rRNA
H6850_04545	COG0443	Heat shock 70 kDa protein
H6850_04555	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H6850_04560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H6850_04565	COG0740	serine-type endopeptidase activity
H6850_04570	COG0336	Belongs to the RNA methyltransferase TrmD family
H6850_04575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6850_04575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H6850_04585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H6850_04590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H6850_04605	COG1530	ribonuclease E activity
H6850_04615	COG0049	tRNA binding
H6850_04620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H6850_04640	COG0571	ribonuclease III activity
H6850_04645	COG0681	Belongs to the peptidase S26 family
H6850_04650	COG4974	Belongs to the 'phage' integrase family
H6850_04655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H6850_04675	COG0803	Belongs to the bacterial solute-binding protein 9 family
H6850_04695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H6850_04700	COG0823	Involved in the tonB-independent uptake of proteins
H6850_04715	COG1862	Preprotein translocase
H6850_04740	COG1420	regulation of RNA biosynthetic process