locus-tag	class	description
IPN28_00015	COG0560	Phosphoserine phosphatase
IPN28_00055	COG0534	Mate efflux family protein
IPN28_00075	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPN28_00130	COG1475	DNA binding
IPN28_00235	COG0438	transferase activity, transferring glycosyl groups
IPN28_00245	COG0640	Transcriptional regulator
IPN28_00250	COG1028	Short-chain dehydrogenase reductase Sdr
IPN28_00255	COG0194	GDP metabolic process
IPN28_00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPN28_00270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPN28_00300	COG0606	chelatase, subunit chli
IPN28_00340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IPN28_00350	COG1686	Belongs to the peptidase S11 family
IPN28_00355	COG3118	belongs to the thioredoxin family
IPN28_00360	COG1074	ATP-dependent DNA helicase activity
IPN28_00375	COG0802	atpase or kinase
IPN28_00385	COG2205	protein histidine kinase activity
IPN28_00390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPN28_00405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPN28_00405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPN28_00405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPN28_00410	COG1660	Displays ATPase and GTPase activities
IPN28_00415	COG2205	protein histidine kinase activity
IPN28_00420	COG0745	RESPONSE REGULATOR receiver
IPN28_00425	COG0285	dihydrofolate synthase activity
IPN28_00430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPN28_00435	COG0159	tryptophan synthase activity
IPN28_00445	COG0133	tryptophan synthase activity
IPN28_00455	COG0284	orotidine-5'-phosphate decarboxylase activity
IPN28_00465	COG0776	regulation of translation
IPN28_00470	COG0539	negative regulation of cytoplasmic translation
IPN28_00475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPN28_00500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPN28_00505	COG0302	gtp cyclohydrolase
IPN28_00510	COG0215	cysteine-tRNA ligase activity
IPN28_00520	COG0071	Belongs to the small heat shock protein (HSP20) family
IPN28_00535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPN28_00540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IPN28_00550	COG1137	ATPase activity
IPN28_00555	COG1280	lysine exporter protein (LysE YggA)
IPN28_00570	COG0517	IMP dehydrogenase activity
IPN28_00570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPN28_00615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPN28_00635	COG1674	ftsk spoiiie
IPN28_00650	COG0077	Prephenate dehydratase
IPN28_00650	COG1605	Chorismate mutase
IPN28_00665	COG1509	lysine 2,3-aminomutase activity
IPN28_00670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPN28_00685	COG2853	Lipoprotein
IPN28_00710	COG0488	(ABC) transporter
IPN28_00725	COG2818	Glycosylase
IPN28_00740	COG0438	transferase activity, transferring glycosyl groups
IPN28_00750	COG0436	Aminotransferase
IPN28_00755	COG1253	flavin adenine dinucleotide binding
IPN28_00760	COG1530	ribonuclease E activity
IPN28_00765	COG0739	heme binding
IPN28_00790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IPN28_00830	COG4221	oxidoreductase activity
IPN28_00835	COG0109	protoheme IX farnesyltransferase activity
IPN28_00845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPN28_00850	COG1565	acr, cog1565
IPN28_00850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPN28_00855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IPN28_00860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPN28_00865	COG2902	Dehydrogenase
IPN28_00885	COG3209	COG3209 Rhs family protein
IPN28_00905	COG1794	racemase activity, acting on amino acids and derivatives
IPN28_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPN28_00925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPN28_00935	COG2205	protein histidine kinase activity
IPN28_00950	COG3038	cytochrome b561
IPN28_00955	COG2353	YceI-like domain
IPN28_00965	COG0742	ribosomal rna small subunit methyltransferase
IPN28_00970	COG1187	pseudouridine synthase activity
IPN28_00975	COG0590	tRNA wobble adenosine to inosine editing
IPN28_00985	COG0151	Belongs to the GarS family
IPN28_00995	COG1570	exodeoxyribonuclease VII activity
IPN28_01010	COG2310	stress, protein
IPN28_01015	COG0530	calcium, potassium:sodium antiporter activity
IPN28_01025	COG0366	Alpha amylase catalytic
IPN28_01055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPN28_01080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPN28_01090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IPN28_01095	COG0156	8-amino-7-oxononanoate synthase activity
IPN28_01110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPN28_01120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPN28_01125	COG0268	Binds directly to 16S ribosomal RNA
IPN28_01135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPN28_01170	COG0459	protein refolding
IPN28_01175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPN28_01180	COG5425	PFAM Usg family protein
IPN28_01195	COG1612	heme a metabolic process
IPN28_01235	COG0318	PFAM AMP-dependent synthetase and ligase
IPN28_01235	COG0204	Acyl-transferase
IPN28_01240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPN28_01245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPN28_01250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPN28_01270	COG0367	asparagine synthase
IPN28_01280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPN28_01310	COG4633	Protein conserved in bacteria
IPN28_01350	COG0071	Belongs to the small heat shock protein (HSP20) family
IPN28_01390	COG3047	cAMP biosynthetic process
IPN28_01415	COG2010	Cytochrome c
IPN28_01485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPN28_01490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPN28_01510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPN28_01560	COG2197	response regulator
IPN28_01615	COG0745	RESPONSE REGULATOR receiver
IPN28_01640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IPN28_01645	COG0861	Integral membrane protein TerC family
IPN28_01650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPN28_01655	COG0131	Imidazoleglycerol-phosphate dehydratase
IPN28_01665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPN28_01670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPN28_01680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPN28_01690	COG0140	phosphoribosyl-ATP diphosphatase activity
IPN28_01715	COG0357	Ribosomal RNA small subunit methyltransferase G
IPN28_01725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPN28_01765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IPN28_01770	COG1981	membrane
IPN28_01810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IPN28_01815	COG0505	Belongs to the CarA family
IPN28_01820	COG0237	dephospho-CoA kinase activity
IPN28_01830	COG0424	maF-like protein
IPN28_01840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IPN28_01845	COG3030	protein affecting phage T7 exclusion by the F plasmid
IPN28_01855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IPN28_01885	COG0667	Aldo Keto reductase
IPN28_02010	COG1704	LemA family
IPN28_02020	COG2226	methyltransferase
IPN28_02025	COG0670	Belongs to the BI1 family
IPN28_02030	COG1970	mechanosensitive ion channel activity
IPN28_02040	COG0582	viral genome integration into host DNA
IPN28_02060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPN28_02120	COG1002	Type II restriction enzyme, methylase subunits
IPN28_02130	COG1061	Type III restriction enzyme res subunit
IPN28_02135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPN28_02175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPN28_02210	COG2814	Major facilitator Superfamily
IPN28_02225	COG5507	3-demethylubiquinone-9 3-methyltransferase
IPN28_02235	COG0640	Transcriptional regulator
IPN28_02240	COG1678	Uncharacterized ACR, COG1678
IPN28_02245	COG0612	Peptidase, M16
IPN28_02270	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPN28_02295	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPN28_02325	COG3541	Predicted nucleotidyltransferase
IPN28_02345	COG0519	Catalyzes the synthesis of GMP from XMP
IPN28_02360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IPN28_02370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IPN28_02425	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IPN28_02450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IPN28_02455	COG0511	ligase activity, forming carbon-carbon bonds
IPN28_02460	COG0439	Biotin carboxylase
IPN28_02465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPN28_02520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPN28_02530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPN28_02540	COG0438	transferase activity, transferring glycosyl groups
IPN28_02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPN28_02600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPN28_02605	COG0594	ribonuclease P activity
IPN28_02610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPN28_02615	COG0706	membrane insertase activity
IPN28_02620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPN28_02625	COG1322	Protein conserved in bacteria
IPN28_02630	COG0242	peptide deformylase activity
IPN28_02655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPN28_02665	COG2171	N-acyltransferase activity
IPN28_02680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPN28_02720	COG2264	protein methyltransferase activity
IPN28_02730	COG0183	Belongs to the thiolase family
IPN28_02750	COG1024	Enoyl-CoA hydratase
IPN28_02750	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPN28_02785	COG1960	acyl-CoA dehydrogenase activity
IPN28_02820	COG1999	signal sequence binding
IPN28_02825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IPN28_02830	COG2824	Alkylphosphonate utilization operon protein PhnA
IPN28_02880	COG0678	peroxiredoxin activity
IPN28_02925	COG1702	phosphate starvation-inducible protein PhoH
IPN28_02935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPN28_02945	COG0004	ammonium transporteR
IPN28_02965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPN28_02975	COG0469	pyruvate kinase activity
IPN28_02995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPN28_03005	COG0322	excinuclease ABC activity
IPN28_03020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPN28_03030	COG0360	Binds together with S18 to 16S ribosomal RNA
IPN28_03035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPN28_03040	COG0359	binds to the 23S rRNA
IPN28_03050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPN28_03065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPN28_03070	COG1127	ABC transporter
IPN28_03075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPN28_03095	COG3264	Mechanosensitive ion channel
IPN28_03095	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IPN28_03115	COG0386	Belongs to the glutathione peroxidase family
IPN28_03155	COG1518	maintenance of DNA repeat elements
IPN28_03160	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IPN28_03185	COG0582	viral genome integration into host DNA
IPN28_03215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPN28_03220	COG3118	belongs to the thioredoxin family
IPN28_03225	COG2835	tetraacyldisaccharide 4'-kinase activity
IPN28_03245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPN28_03295	COG1573	uracil-dna glycosylase
IPN28_03305	COG1758	RNA polymerase activity
IPN28_03310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPN28_03315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPN28_03320	COG0736	holo-[acyl-carrier-protein] synthase activity
IPN28_03330	COG0571	ribonuclease III activity
IPN28_03335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPN28_03360	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPN28_03365	COG1278	Cold shock
IPN28_03370	COG0318	PFAM AMP-dependent synthetase and ligase
IPN28_03400	COG1214	PFAM Peptidase M22, glycoprotease
IPN28_03400	COG0456	acetyltransferase
IPN28_03405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPN28_03430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPN28_03435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPN28_03445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPN28_03445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPN28_03450	COG2081	HI0933 family
IPN28_03455	COG1187	pseudouridine synthase activity
IPN28_03465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPN28_03500	COG3550	peptidyl-serine autophosphorylation
IPN28_03505	COG2217	Heavy metal translocating P-type atpase
IPN28_03555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPN28_03565	COG1064	alcohol dehydrogenase
IPN28_03580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IPN28_03590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPN28_03590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPN28_03615	COG1686	Belongs to the peptidase S11 family
IPN28_03630	COG0235	Class ii aldolase
IPN28_03635	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IPN28_03640	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IPN28_03645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPN28_03695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IPN28_03715	COG0746	molybdenum cofactor guanylyltransferase activity
IPN28_03720	COG0314	molybdopterin synthase activity
IPN28_03730	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPN28_03730	COG0315	cyclic pyranopterin monophosphate synthase activity
IPN28_03735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPN28_03760	COG2181	nitrate reductase activity
IPN28_03765	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IPN28_03775	COG1140	nitrate reductase beta subunit
IPN28_03780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPN28_03785	COG2223	nitrite transmembrane transporter activity
IPN28_03795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPN28_03810	COG0826	peptidase U32
IPN28_03840	COG0602	queuosine metabolic process
IPN28_03855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPN28_03890	COG2274	protein secretion by the type I secretion system
IPN28_03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPN28_03900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPN28_03905	COG0509	glycine decarboxylation via glycine cleavage system
IPN28_03910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPN28_03925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPN28_03960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPN28_03965	COG0081	regulation of translation
IPN28_03975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPN28_03980	COG0222	ribosome binding
IPN28_03985	COG0085	RNA polymerase activity
IPN28_03995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPN28_04010	COG0049	tRNA binding
IPN28_04015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPN28_04020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPN28_04025	COG0051	transcription antitermination factor activity, RNA binding
IPN28_04040	COG0088	Forms part of the polypeptide exit tunnel
IPN28_04045	COG0089	rRNA binding
IPN28_04050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPN28_04055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPN28_04060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPN28_04070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPN28_04075	COG0255	Belongs to the universal ribosomal protein uL29 family
IPN28_04080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPN28_04085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPN28_04095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPN28_04105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPN28_04115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPN28_04120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPN28_04125	COG1841	ribosomal large subunit assembly
IPN28_04130	COG0200	Binds to the 23S rRNA
IPN28_04155	COG1446	asparaginase
IPN28_04160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPN28_04165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPN28_04175	COG0203	ribosomal protein L17
IPN28_04180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPN28_04190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPN28_04205	COG0423	glycine-tRNA ligase activity
IPN28_04230	COG1960	acyl-CoA dehydrogenase activity
IPN28_04250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPN28_04255	COG0175	sulfate reduction
IPN28_04265	COG1218	3'(2'),5'-bisphosphate nucleotidase
IPN28_04290	COG1595	DNA-templated transcription, initiation
IPN28_04295	COG2304	oxidoreductase activity
IPN28_04315	COG0488	(ABC) transporter
IPN28_04325	COG5383	Protein conserved in bacteria
IPN28_04330	COG1012	belongs to the aldehyde dehydrogenase family
IPN28_04345	COG1748	Saccharopine dehydrogenase
IPN28_04360	COG0300	oxidoreductase activity
IPN28_04375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPN28_04380	COG0659	secondary active sulfate transmembrane transporter activity
IPN28_04400	COG0175	sulfate reduction
IPN28_04405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPN28_04405	COG1648	precorrin-2 dehydrogenase activity
IPN28_04430	COG2957	Belongs to the agmatine deiminase family
IPN28_04500	COG1696	Membrane protein involved in D-alanine export
IPN28_04545	COG2133	pyrroloquinoline quinone binding
IPN28_04550	COG2373	Large extracellular alpha-helical protein
IPN28_04565	COG1509	lysine 2,3-aminomutase activity
IPN28_04570	COG1295	ribonuclease BN
IPN28_04585	COG0538	isocitrate dehydrogenase activity
IPN28_04590	COG0643	Histidine kinase
IPN28_04590	COG2198	Histidine kinase
IPN28_04615	COG0745	RESPONSE REGULATOR receiver
IPN28_04635	COG2204	response regulator
IPN28_04645	COG0745	RESPONSE REGULATOR receiver
IPN28_04655	COG0438	transferase activity, transferring glycosyl groups
IPN28_04665	COG1216	Glycosyl transferase, family 2
IPN28_04680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPN28_04710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IPN28_04715	COG0720	synthase
IPN28_04720	COG0602	queuosine metabolic process
IPN28_04725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IPN28_04735	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IPN28_04750	COG0714	Associated with various cellular activities
IPN28_04770	COG2304	oxidoreductase activity
IPN28_04800	COG1136	(ABC) transporter
IPN28_04810	COG1309	transcriptional regulator
IPN28_04820	COG0840	transmembrane signaling receptor activity
IPN28_04830	COG1741	Belongs to the pirin family
IPN28_04835	COG1217	gtp-binding protein TYPA
IPN28_04845	COG2985	domain, Protein
IPN28_04845	COG3273	potassium ion transport
IPN28_04850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPN28_04860	COG4953	penicillin-binding protein 1C
IPN28_04875	COG0306	phosphate transporter
IPN28_04880	COG1392	Phosphate transport regulator
IPN28_04885	COG1028	Short-chain dehydrogenase reductase Sdr
IPN28_04890	COG1505	serine-type exopeptidase activity
IPN28_04925	COG1881	PFAM PEBP family protein
IPN28_04930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPN28_04940	COG3246	L-lysine catabolic process to acetate
IPN28_04955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPN28_04975	COG2304	oxidoreductase activity
IPN28_04990	COG1132	(ABC) transporter
IPN28_05000	COG1902	pentaerythritol trinitrate reductase activity
IPN28_05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPN28_05035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPN28_05050	COG1671	Belongs to the UPF0178 family
IPN28_05070	COG0488	(ABC) transporter
IPN28_05100	COG1573	uracil-dna glycosylase
IPN28_05125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPN28_05155	COG0105	UTP biosynthetic process
IPN28_05170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPN28_05175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPN28_05185	COG0628	permease
IPN28_05200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPN28_05210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPN28_05240	COG3447	MASE1 domain protein
IPN28_05240	COG5001	Diguanylate cyclase
IPN28_05240	COG5002	protein histidine kinase activity
IPN28_05250	COG0784	Response regulator, receiver
IPN28_05265	COG0557	exoribonuclease II activity
IPN28_05270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPN28_05275	COG0758	DNA mediated transformation
IPN28_05295	COG0540	Belongs to the ATCase OTCase family
IPN28_05310	COG0784	Response regulator, receiver
IPN28_05310	COG2205	protein histidine kinase activity
IPN28_05310	COG5002	protein histidine kinase activity
IPN28_05315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IPN28_05345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IPN28_05370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPN28_05375	COG1872	DUF167
IPN28_05385	COG3550	peptidyl-serine autophosphorylation
IPN28_05400	COG0583	DNA-binding transcription factor activity
IPN28_05405	COG0384	phenazine biosynthesis protein PhzF
IPN28_05420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPN28_05435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPN28_05440	COG0564	pseudouridine synthase activity
IPN28_05480	COG0612	Peptidase, M16
IPN28_05485	COG0612	Peptidase, M16
IPN28_05495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPN28_05510	COG3220	belongs to the UPF0276 family
IPN28_05520	COG0196	riboflavin kinase activity
IPN28_05535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPN28_05545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPN28_05550	COG3023	N-Acetylmuramoyl-L-alanine amidase
IPN28_05560	COG2001	Belongs to the MraZ family
IPN28_05565	COG0275	rRNA processing
IPN28_05580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPN28_05590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPN28_05595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPN28_05605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPN28_05610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPN28_05620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPN28_05635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPN28_05640	COG2267	carboxylic ester hydrolase activity
IPN28_05645	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPN28_05650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPN28_05655	COG0849	cell division
IPN28_05665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPN28_05675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPN28_05680	COG0497	DNA recombination
IPN28_05695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPN28_05750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPN28_05765	COG5001	Diguanylate cyclase
IPN28_05765	COG4251	negative regulation of phosphorylation
IPN28_05765	COG3706	GGDEF domain
IPN28_05765	COG2203	Gaf domain
IPN28_05770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPN28_05790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPN28_05795	COG0772	Belongs to the SEDS family
IPN28_05830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPN28_05855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPN28_06075	COG0473	3-isopropylmalate dehydrogenase activity
IPN28_06085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPN28_06100	COG0626	cystathionine gamma-synthase activity
IPN28_06110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPN28_06175	COG2890	protein-(glutamine-N5) methyltransferase activity
IPN28_06190	COG0481	GTPase activity
IPN28_06230	COG0138	bifunctional purine biosynthesis protein purh
IPN28_06235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IPN28_06240	COG2201	protein-glutamate methylesterase activity
IPN28_06245	COG0745	RESPONSE REGULATOR receiver
IPN28_06255	COG0784	Response regulator, receiver
IPN28_06255	COG2198	Histidine kinase
IPN28_06255	COG0643	Histidine kinase
IPN28_06285	COG0006	proline dipeptidase activity
IPN28_06295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPN28_06305	COG4172	Belongs to the ABC transporter superfamily
IPN28_06325	COG0165	Argininosuccinate lyase
IPN28_06340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPN28_06365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPN28_06380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPN28_06385	COG1690	Belongs to the RtcB family
IPN28_06390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IPN28_06400	COG1473	amidohydrolase
IPN28_06405	COG4239	(ABC) transporter, permease
IPN28_06415	COG4174	ABC transporter (Permease)
IPN28_06425	COG0588	phosphoglycerate mutase activity
IPN28_06430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPN28_06435	COG4166	transmembrane transport
IPN28_06445	COG0167	dihydroorotate dehydrogenase activity
IPN28_06450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPN28_06475	COG0745	RESPONSE REGULATOR receiver
IPN28_06515	COG1419	protein localization to endoplasmic reticulum
IPN28_06515	COG1419	protein localization to endoplasmic reticulum
IPN28_06525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IPN28_06535	COG2204	response regulator
IPN28_06545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IPN28_06550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IPN28_06560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IPN28_06585	COG5443	negative regulation of bacterial-type flagellum assembly
IPN28_06595	COG2226	methyltransferase
IPN28_06615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IPN28_06640	COG1706	bacterial-type flagellum-dependent cell motility
IPN28_06655	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IPN28_06665	COG4786	Flagellar basal body rod
IPN28_06670	COG4786	Flagellar basal body rod
IPN28_06695	COG0745	RESPONSE REGULATOR receiver
IPN28_06710	COG1360	Flagellar Motor Protein
IPN28_06720	COG1338	Plays a role in the flagellum-specific transport system
IPN28_06740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IPN28_06745	COG1815	bacterial-type flagellum-dependent cell motility
IPN28_06750	COG1558	bacterial-type flagellum-dependent cell motility
IPN28_06755	COG1677	Flagellar hook-basal body complex protein FliE
IPN28_06770	COG1987	bacterial-type flagellum assembly
IPN28_06775	COG1684	flagellar biosynthetic protein fliR
IPN28_06780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IPN28_06790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPN28_06800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPN28_06805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPN28_06810	COG0741	lytic transglycosylase activity
IPN28_06850	COG0714	Associated with various cellular activities
IPN28_06860	COG0617	tRNA 3'-terminal CCA addition
IPN28_06870	COG0408	coproporphyrinogen oxidase activity
IPN28_06875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IPN28_06890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPN28_06890	COG2857	Cytochrome c1
IPN28_06915	COG0516	GMP reductase activity
IPN28_06925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPN28_06930	COG2226	methyltransferase
IPN28_06940	COG1040	competence protein
IPN28_06945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPN28_06950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IPN28_06955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPN28_06960	COG0626	cystathionine gamma-synthase activity
IPN28_06965	COG0433	COG0433 Predicted ATPase
IPN28_06970	COG3620	sequence-specific DNA binding
IPN28_06980	COG0400	carboxylic ester hydrolase activity
IPN28_06995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IPN28_07025	COG0471	metal ion transport
IPN28_07025	COG3273	potassium ion transport
IPN28_07030	COG1959	2 iron, 2 sulfur cluster binding
IPN28_07060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPN28_07095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IPN28_07110	COG1663	tetraacyldisaccharide 4'-kinase activity
IPN28_07115	COG1519	Transferase
IPN28_07150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPN28_07200	COG0629	single-stranded DNA binding
IPN28_07210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPN28_07220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPN28_07270	COG2963	transposase activity
IPN28_07280	COG1045	serine acetyltransferase
IPN28_07290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPN28_07310	COG0513	Belongs to the DEAD box helicase family
IPN28_07315	COG1278	Cold shock
IPN28_07335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IPN28_07350	COG0436	Aminotransferase
IPN28_07365	COG0492	ferredoxin-NADP+ reductase activity
IPN28_07370	COG1522	sequence-specific DNA binding
IPN28_07380	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IPN28_07390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPN28_07405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPN28_07410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPN28_07420	COG0492	ferredoxin-NADP+ reductase activity
IPN28_07425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPN28_07435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPN28_07445	COG2226	methyltransferase
IPN28_07455	COG0180	Tryptophanyl-tRNA synthetase
IPN28_07465	COG0730	response to heat
IPN28_07480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IPN28_07485	COG1214	PFAM Peptidase M22, glycoprotease
IPN28_07490	COG4957	zinc ion binding
IPN28_07525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPN28_07530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPN28_07535	COG0193	aminoacyl-tRNA hydrolase activity
IPN28_07540	COG0012	GTP binding
IPN28_07560	COG0745	RESPONSE REGULATOR receiver
IPN28_07565	COG2205	protein histidine kinase activity
IPN28_07570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPN28_07585	COG2137	regulation of response to DNA damage stimulus
IPN28_07620	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IPN28_07665	COG0114	fumarate hydratase activity
IPN28_07670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPN28_07685	COG0205	6-phosphofructokinase activity
IPN28_07700	COG0129	dihydroxy-acid dehydratase activity
IPN28_07705	COG2989	Protein conserved in bacteria
IPN28_07710	COG3108	Peptidase M15
IPN28_07715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPN28_07720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPN28_07730	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IPN28_07735	COG1381	Involved in DNA repair and RecF pathway recombination
IPN28_07740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPN28_07755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IPN28_07760	COG0113	porphobilinogen synthase activity
IPN28_07775	COG0698	ribose 5-phosphate isomerase
IPN28_07790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPN28_07795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPN28_07795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPN28_07805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPN28_07805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPN28_07810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPN28_07815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPN28_07840	COG2855	membrane
IPN28_07850	COG0416	fatty acid biosynthetic process
IPN28_07860	COG0776	regulation of translation
IPN28_07875	COG3739	integral membrane protein
IPN28_07895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPN28_07900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPN28_07915	COG3243	poly(R)-hydroxyalkanoic acid synthase
IPN28_07930	COG1494	fructose-1,6-bisphosphatase
IPN28_07935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPN28_07950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPN28_07960	COG0189	ligase activity
IPN28_07965	COG0513	Belongs to the DEAD box helicase family
IPN28_07985	COG0187	DNA topoisomerase II activity
IPN28_08005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPN28_08005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPN28_08015	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPN28_08030	COG0776	regulation of translation
IPN28_08065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPN28_08070	COG0686	Belongs to the AlaDH PNT family
IPN28_08090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPN28_08095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPN28_08100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPN28_08105	COG0649	NAD binding
IPN28_08115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IPN28_08145	COG0047	phosphoribosylformylglycinamidine synthase activity
IPN28_08150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPN28_08160	COG1034	ATP synthesis coupled electron transport
IPN28_08180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPN28_08185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPN28_08195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IPN28_08205	COG0713	ATP synthesis coupled electron transport
IPN28_08220	COG1007	ATP synthesis coupled electron transport
IPN28_08225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IPN28_08225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IPN28_08250	COG0442	prolyl-tRNA aminoacylation
IPN28_08260	COG1136	(ABC) transporter
IPN28_08265	COG2267	carboxylic ester hydrolase activity
IPN28_08275	COG0052	Belongs to the universal ribosomal protein uS2 family
IPN28_08280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPN28_08285	COG0528	UMP kinase activity
IPN28_08290	COG0233	cytoplasmic translational termination
IPN28_08295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPN28_08300	COG0575	Belongs to the CDS family
IPN28_08310	COG0750	zinc metalloprotease
IPN28_08315	COG0750	zinc metalloprotease
IPN28_08320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPN28_08330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPN28_08335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPN28_08345	COG3494	Protein of unknown function (DUF1009)
IPN28_08350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPN28_08360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPN28_08375	COG0134	indole-3-glycerol-phosphate synthase activity
IPN28_08390	COG2861	carbohydrate metabolic process
IPN28_08395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPN28_08405	COG0149	triose-phosphate isomerase activity
IPN28_08415	COG0504	CTP synthase activity
IPN28_08420	COG2226	methyltransferase
IPN28_08435	COG0148	phosphopyruvate hydratase activity
IPN28_08440	COG1678	Uncharacterized ACR, COG1678
IPN28_08450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPN28_08465	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPN28_08465	COG0022	dehydrogenase e1 component
IPN28_08475	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPN28_08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPN28_08500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPN28_08505	COG2867	negative regulation of translational initiation
IPN28_08510	COG1058	Belongs to the CinA family
IPN28_08510	COG1546	Belongs to the CinA family
IPN28_08515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IPN28_08520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPN28_08520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPN28_08530	COG2204	response regulator
IPN28_08535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPN28_08545	COG1923	regulation of RNA biosynthetic process
IPN28_08550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPN28_08565	COG3956	TIGRFAM MazG family protein
IPN28_08580	COG2201	protein-glutamate methylesterase activity
IPN28_08585	COG2201	protein-glutamate methylesterase activity
IPN28_08600	COG0735	belongs to the Fur family
IPN28_08635	COG0084	hydrolase, TatD family'
IPN28_08640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPN28_08650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPN28_08655	COG1686	Belongs to the peptidase S11 family
IPN28_08660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPN28_08665	COG2951	lytic endotransglycosylase activity
IPN28_08675	COG0586	Pfam SNARE associated Golgi protein
IPN28_08855	COG0436	Aminotransferase
IPN28_08875	COG1321	iron dependent repressor
IPN28_08880	COG1914	H( )-stimulated, divalent metal cation uptake system
IPN28_08885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPN28_08890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPN28_08895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPN28_08900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPN28_08905	COG0308	aminopeptidase N
IPN28_08930	COG1194	a g-specific adenine glycosylase
IPN28_08940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPN28_08945	COG0483	inositol monophosphate 1-phosphatase activity
IPN28_08960	COG1196	nuclear chromosome segregation
IPN28_08970	COG0356	it plays a direct role in the translocation of protons across the membrane
IPN28_08980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPN28_08985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPN28_08995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPN28_09000	COG0799	negative regulation of ribosome biogenesis
IPN28_09005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPN28_09015	COG0793	Belongs to the peptidase S41A family
IPN28_09025	COG1051	belongs to the nudix hydrolase family
IPN28_09040	COG0848	biopolymer transport protein
IPN28_09045	COG0811	peptide transport
IPN28_09050	COG0824	Thioesterase
IPN28_09065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPN28_09070	COG0217	transcriptional regulatory protein
IPN28_09085	COG1692	metallophosphoesterase
IPN28_09090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IPN28_09125	COG1830	Aldolase
IPN28_09140	COG0254	rRNA binding
IPN28_09150	COG0525	valine-tRNA ligase activity
IPN28_09160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPN28_09195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPN28_09200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPN28_09230	COG2897	thiosulfate sulfurtransferase activity
IPN28_09245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPN28_09315	COG3209	COG3209 Rhs family protein
IPN28_09345	COG1475	DNA binding
IPN28_09360	COG1196	nuclear chromosome segregation
IPN28_09385	COG1396	sequence-specific DNA binding
IPN28_09435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPN28_09435	COG0617	tRNA 3'-terminal CCA addition
IPN28_09435	COG0517	IMP dehydrogenase activity
IPN28_09450	COG1132	(ABC) transporter
IPN28_09455	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPN28_09470	COG1115	amino acid carrier protein
IPN28_09480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPN28_09485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPN28_09495	COG1702	phosphate starvation-inducible protein PhoH
IPN28_09500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPN28_09510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPN28_09515	COG1396	sequence-specific DNA binding
IPN28_09520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPN28_09525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPN28_09530	COG0779	Required for maturation of 30S ribosomal subunits
IPN28_09540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPN28_09545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPN28_09550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPN28_09555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPN28_09570	COG0588	phosphoglycerate mutase activity
IPN28_09575	COG1185	polyribonucleotide nucleotidyltransferase activity
IPN28_09605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPN28_09620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPN28_09630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPN28_09645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IPN28_09655	COG0316	Belongs to the HesB IscA family
IPN28_09660	COG2151	metal-sulfur cluster biosynthetic enzyme
IPN28_09670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPN28_09675	COG2852	Protein conserved in bacteria
IPN28_09690	COG0719	Fe-S assembly protein
IPN28_09700	COG0396	ATPase activity
IPN28_09730	COG0719	Fe-S assembly protein
IPN28_09735	COG1959	2 iron, 2 sulfur cluster binding
IPN28_09745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IPN28_09770	COG2205	protein histidine kinase activity
IPN28_09780	COG0343	queuine tRNA-ribosyltransferase activity
IPN28_09785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPN28_09790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IPN28_09805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPN28_09810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPN28_09820	COG0154	amidase activity
IPN28_09830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPN28_09870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IPN28_09880	COG1278	Cold shock
IPN28_09905	COG1333	cytochrome c biogenesis protein
IPN28_09905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPN28_09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPN28_09915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPN28_09920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPN28_09930	COG0542	response to heat
IPN28_09940	COG2890	protein-(glutamine-N5) methyltransferase activity
IPN28_09945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPN28_09955	COG0527	aspartate kinase activity
IPN28_09960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPN28_09975	COG2086	electron transfer activity
IPN28_09990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPN28_10000	COG0019	diaminopimelate decarboxylase activity
IPN28_10020	COG2884	Cell division ATP-binding protein ftsE
IPN28_10040	COG0287	Prephenate dehydrogenase
IPN28_10050	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IPN28_10065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPN28_10080	COG0656	L-ascorbic acid biosynthetic process
IPN28_10085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPN28_10090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPN28_10105	COG4974	Belongs to the 'phage' integrase family
IPN28_10110	COG0825	malonyl-CoA metabolic process
IPN28_10160	COG0124	histidyl-tRNA synthetase
IPN28_10175	COG2166	iron-sulfur cluster assembly
IPN28_10180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPN28_10205	COG0463	Glycosyl transferase, family 2
IPN28_10220	COG0415	Belongs to the DNA photolyase family
IPN28_10225	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPN28_10240	COG4783	chaperone-mediated protein folding
IPN28_10255	COG0126	phosphoglycerate kinase activity
IPN28_10270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IPN28_10275	COG0552	protein localization to endoplasmic reticulum
IPN28_10280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPN28_10290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPN28_10295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPN28_10300	COG0228	four-way junction DNA binding
IPN28_10305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPN28_10310	COG0336	Belongs to the RNA methyltransferase TrmD family
IPN28_10315	COG0335	large ribosomal subunit rRNA binding
IPN28_10345	COG0066	3-isopropylmalate dehydratase activity
IPN28_10350	COG0473	3-isopropylmalate dehydrogenase activity
IPN28_10360	COG0330	HflC and HflK could
IPN28_10370	COG1917	Cupin 2, conserved barrel domain protein
IPN28_10370	COG2169	Transcriptional regulator
IPN28_10385	COG1450	Type ii and iii secretion system protein
IPN28_10400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPN28_10410	COG1131	(ABC) transporter
IPN28_10430	COG1459	type II secretion system
IPN28_10435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPN28_10490	COG1196	nuclear chromosome segregation
IPN28_10495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPN28_10500	COG0358	DNA primase activity
IPN28_10505	COG1610	YqeY-like protein
IPN28_10510	COG0505	Belongs to the CarA family
IPN28_10530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPN28_10545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IPN28_10560	COG3737	Protein of unknown function (DUF498/DUF598)
IPN28_10570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPN28_10575	COG1862	Preprotein translocase
IPN28_10595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPN28_10605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPN28_10635	COG2239	Acts as a magnesium transporter
IPN28_10640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPN28_10645	COG0328	RNA-DNA hybrid ribonuclease activity
IPN28_10650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IPN28_10655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPN28_10670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IPN28_10675	COG1722	exodeoxyribonuclease VII activity
IPN28_10680	COG0142	geranyltranstransferase activity
IPN28_10695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPN28_10705	COG0616	signal peptide processing
IPN28_10710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IPN28_10715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPN28_10730	COG2050	protein possibly involved in aromatic compounds catabolism
IPN28_10740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPN28_10750	COG4520	surface antigen
IPN28_10785	COG0156	8-amino-7-oxononanoate synthase activity
IPN28_10805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPN28_10815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IPN28_10820	COG4166	transmembrane transport
IPN28_10845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPN28_10845	COG0574	Belongs to the PEP-utilizing enzyme family
IPN28_10860	COG0142	geranyltranstransferase activity
IPN28_10885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPN28_10895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPN28_10900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPN28_10915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPN28_10930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPN28_10940	COG0745	RESPONSE REGULATOR receiver
IPN28_10940	COG2205	protein histidine kinase activity
IPN28_10940	COG3292	Two component regulator propeller
IPN28_10945	COG0745	RESPONSE REGULATOR receiver
IPN28_10950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPN28_10950	COG2169	Transcriptional regulator
IPN28_10955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPN28_11050	COG0438	transferase activity, transferring glycosyl groups
IPN28_11060	COG2327	Polysaccharide pyruvyl transferase
IPN28_11070	COG1215	transferase activity, transferring glycosyl groups
IPN28_11075	COG3239	Fatty acid desaturase
IPN28_11080	COG1546	Belongs to the CinA family
IPN28_11080	COG1058	Belongs to the CinA family
IPN28_11085	COG0024	Methionine aminopeptidase
IPN28_11095	COG2003	Belongs to the UPF0758 family
IPN28_11100	COG3034	peptidoglycan biosynthetic process
IPN28_11105	COG3738	Protein conserved in bacteria
IPN28_11110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPN28_11210	COG0556	nucleotide-excision repair
IPN28_11250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IPN28_11250	COG1199	ATP-dependent helicase activity
IPN28_11260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPN28_11265	COG0512	Glutamine amidotransferase of anthranilate synthase
IPN28_11280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPN28_11300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPN28_11310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPN28_11360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPN28_11380	COG4974	Belongs to the 'phage' integrase family
IPN28_11425	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPN28_11440	COG0352	thiamine-phosphate diphosphorylase activity
IPN28_11440	COG0351	phosphomethylpyrimidine kinase
IPN28_11445	COG0352	thiamine-phosphate diphosphorylase activity
IPN28_11495	COG0045	succinate-CoA ligase (ADP-forming) activity
IPN28_11505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IPN28_11515	COG0039	L-malate dehydrogenase activity
IPN28_11555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IPN28_11560	COG0805	protein transport
IPN28_11565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPN28_11575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPN28_11580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPN28_11585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPN28_11590	COG1472	Belongs to the glycosyl hydrolase 3 family
IPN28_11600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IPN28_11615	COG0316	Belongs to the HesB IscA family
IPN28_11670	COG1794	racemase activity, acting on amino acids and derivatives
IPN28_11720	COG0745	RESPONSE REGULATOR receiver
IPN28_11730	COG0717	Belongs to the dCTP deaminase family
IPN28_11735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPN28_11745	COG3034	peptidoglycan biosynthetic process
IPN28_11755	COG3034	peptidoglycan biosynthetic process
IPN28_11780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPN28_11785	COG5328	Belongs to the UPF0262 family
IPN28_11790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPN28_11795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPN28_11795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPN28_11830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPN28_11865	COG0564	pseudouridine synthase activity
IPN28_11875	COG0438	transferase activity, transferring glycosyl groups
IPN28_12000	COG3209	COG3209 Rhs family protein
IPN28_12055	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IPN28_12065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPN28_12080	COG0640	Transcriptional regulator
IPN28_12090	COG4589	Belongs to the CDS family
IPN28_12115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPN28_12120	COG0640	Transcriptional regulator
IPN28_12125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPN28_12165	COG4964	Belongs to the GSP D family
IPN28_12210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPN28_12215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IPN28_12225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPN28_12245	COG0037	tRNA processing
IPN28_12255	COG2885	chlorophyll binding
IPN28_12270	COG0792	nuclease activity
IPN28_12275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPN28_12280	COG3107	peptidoglycan biosynthetic process
IPN28_12290	COG1309	transcriptional regulator
IPN28_12305	COG1054	Belongs to the UPF0176 family
IPN28_12310	COG1254	Belongs to the acylphosphatase family
IPN28_12325	COG1595	DNA-templated transcription, initiation
IPN28_12345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPN28_12360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IPN28_12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPN28_12365	COG0339	signal peptide processing
IPN28_12385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IPN28_12405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IPN28_12405	COG0662	Cupin 2, conserved barrel domain protein
IPN28_12410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPN28_12415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IPN28_12455	COG0009	L-threonylcarbamoyladenylate synthase
IPN28_12460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPN28_12465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IPN28_12495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPN28_12500	COG2945	thiolester hydrolase activity
IPN28_12505	COG1104	cysteine desulfurase activity
IPN28_12510	COG0633	Ferredoxin
IPN28_12530	COG0482	sulfurtransferase activity
IPN28_12575	COG1597	lipid kinase activity
IPN28_12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPN28_12655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPN28_12665	COG1960	acyl-CoA dehydrogenase activity
IPN28_12680	COG1696	Membrane protein involved in D-alanine export
IPN28_12690	COG0676	glucose-6-phosphate 1-epimerase activity
IPN28_12745	COG3420	alginic acid biosynthetic process
IPN28_12760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPN28_12795	COG0778	Nitroreductase
IPN28_12815	COG2354	Protein conserved in bacteria
IPN28_12820	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IPN28_12820	COG3266	domain, Protein
IPN28_12820	COG4932	domain protein
IPN28_12840	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IPN28_12840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPN28_12845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPN28_12920	COG3878	Protein conserved in bacteria
IPN28_12930	COG0326	Molecular chaperone. Has ATPase activity
IPN28_12975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPN28_12995	COG2022	thiamine diphosphate biosynthetic process
IPN28_13000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPN28_13010	COG1278	Cold shock
IPN28_13090	COG1283	sodium-dependent phosphate transmembrane transporter activity
IPN28_13100	COG1216	Glycosyl transferase, family 2
IPN28_13125	COG0730	response to heat
IPN28_13155	COG1733	regulation of RNA biosynthetic process
IPN28_13180	COG0181	hydroxymethylbilane synthase activity
IPN28_13185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPN28_13190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPN28_13200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPN28_13225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPN28_13265	COG1131	(ABC) transporter
IPN28_13305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPN28_13315	COG0489	protein tyrosine kinase activity
IPN28_13320	COG0330	HflC and HflK could
IPN28_13325	COG0330	HflC and HflK could
IPN28_13330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPN28_13365	COG0028	Belongs to the TPP enzyme family
IPN28_13385	COG3158	transport of potassium into the cell
IPN28_13390	COG0440	acetolactate synthase activity
IPN28_13400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPN28_13445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPN28_13445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPN28_13450	COG0784	Response regulator, receiver
IPN28_13455	COG4251	negative regulation of phosphorylation
IPN28_13460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPN28_13465	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPN28_13475	COG1376	ErfK ybiS ycfS ynhG family protein
IPN28_13495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPN28_13500	COG1160	GTP binding
IPN28_13510	COG0668	transmembrane transport
IPN28_13520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPN28_13530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPN28_13535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPN28_13560	COG0745	RESPONSE REGULATOR receiver
IPN28_13570	COG0745	RESPONSE REGULATOR receiver
IPN28_13580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase