locus-tag	class	description
HW532_00010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW532_00035	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HW532_00050	COG3246	L-lysine catabolic process to acetate
HW532_00100	COG2239	Acts as a magnesium transporter
HW532_00110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW532_00115	COG0302	gtp cyclohydrolase
HW532_00135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW532_00155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW532_00160	COG1335	isochorismatase
HW532_00175	COG0745	RESPONSE REGULATOR receiver
HW532_00185	COG0288	reversible hydration of carbon dioxide
HW532_00190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW532_00195	COG1324	tolerance protein
HW532_00210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW532_00250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HW532_00255	COG1840	ABC-type Fe3 transport system, periplasmic component
HW532_00270	COG2308	Evidence 4 Homologs of previously reported genes of
HW532_00305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW532_00315	COG1802	Transcriptional regulator
HW532_00320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW532_00350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW532_00365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW532_00375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW532_00380	COG0250	Participates in transcription elongation, termination and antitermination
HW532_00385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW532_00390	COG0081	regulation of translation
HW532_00395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW532_00400	COG0222	ribosome binding
HW532_00405	COG0085	RNA polymerase activity
HW532_00410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW532_00415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW532_00425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW532_00430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW532_00435	COG0051	transcription antitermination factor activity, RNA binding
HW532_00440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW532_00445	COG0088	Forms part of the polypeptide exit tunnel
HW532_00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW532_00460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW532_00465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW532_00470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW532_00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW532_00480	COG0255	Belongs to the universal ribosomal protein uL29 family
HW532_00485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW532_00490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW532_00495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW532_00500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW532_00505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW532_00510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW532_00525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW532_00530	COG1841	ribosomal large subunit assembly
HW532_00535	COG0200	Binds to the 23S rRNA
HW532_00540	COG0201	protein transport
HW532_00545	COG0563	adenylate kinase activity
HW532_00550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW532_00555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW532_00560	COG0202	RNA polymerase activity
HW532_00565	COG0203	ribosomal protein L17
HW532_00580	COG1522	sequence-specific DNA binding
HW532_00595	COG0564	pseudouridine synthase activity
HW532_00600	COG0546	phosphoglycolate phosphatase activity
HW532_00610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW532_00620	COG3174	membrane
HW532_00635	COG4770	biotin carboxylase activity
HW532_00640	COG1254	Belongs to the acylphosphatase family
HW532_00650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HW532_00655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW532_00660	COG0459	protein refolding
HW532_00665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW532_00670	COG0505	Belongs to the CarA family
HW532_00675	COG1610	YqeY-like protein
HW532_00680	COG0358	DNA primase activity
HW532_00685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW532_00700	COG2968	Membrane
HW532_00710	COG3468	outer membrane autotransporter barrel domain protein
HW532_00720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW532_00725	COG2186	Transcriptional regulator
HW532_00735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW532_00740	COG1012	belongs to the aldehyde dehydrogenase family
HW532_00755	COG0798	PFAM Bile acid sodium symporter
HW532_00760	COG0488	(ABC) transporter
HW532_00775	COG2226	methyltransferase
HW532_00800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW532_00805	COG4166	transmembrane transport
HW532_00815	COG2301	Belongs to the HpcH HpaI aldolase family
HW532_00820	COG0679	Auxin Efflux Carrier
HW532_00825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW532_00830	COG3622	Belongs to the hyi family
HW532_00835	COG0235	Class ii aldolase
HW532_00840	COG3395	kinase activity
HW532_00845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW532_00860	COG3733	amine oxidase
HW532_00865	COG0450	alkyl hydroperoxide reductase
HW532_00870	COG1652	LysM domain
HW532_00920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW532_00980	COG1960	acyl-CoA dehydrogenase activity
HW532_01000	COG0683	leucine binding
HW532_01025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_01045	COG0436	Aminotransferase
HW532_01055	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_01055	COG1902	pentaerythritol trinitrate reductase activity
HW532_01065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW532_01080	COG1024	Enoyl-CoA hydratase
HW532_01080	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_01090	COG1960	acyl-CoA dehydrogenase activity
HW532_01095	COG3791	Glutathione-dependent formaldehyde-activating
HW532_01140	COG3608	succinylglutamate desuccinylase aspartoacylase
HW532_01140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW532_01145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW532_01150	COG2003	Belongs to the UPF0758 family
HW532_01155	COG0024	Methionine aminopeptidase
HW532_01160	COG1489	DNA binding
HW532_01170	COG0442	prolyl-tRNA aminoacylation
HW532_01200	COG0052	Belongs to the universal ribosomal protein uS2 family
HW532_01205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW532_01210	COG0528	UMP kinase activity
HW532_01215	COG0233	cytoplasmic translational termination
HW532_01220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW532_01230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW532_01245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HW532_01260	COG0372	Belongs to the citrate synthase family
HW532_01275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW532_01280	COG0303	'Molybdopterin
HW532_01290	COG0134	indole-3-glycerol-phosphate synthase activity
HW532_01295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW532_01305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW532_01335	COG3264	Mechanosensitive ion channel
HW532_01335	COG1196	nuclear chromosome segregation
HW532_01350	COG3047	cAMP biosynthetic process
HW532_01355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW532_01360	COG0148	phosphopyruvate hydratase activity
HW532_01365	COG0438	transferase activity, transferring glycosyl groups
HW532_01375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HW532_01405	COG1363	Peptidase, m42
HW532_01410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW532_01410	COG0189	ligase activity
HW532_01415	COG0367	asparagine synthase
HW532_01425	COG1846	Transcriptional regulator
HW532_01435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_01450	COG2226	methyltransferase
HW532_01495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HW532_01500	COG1088	dTDP-glucose 4,6-dehydratase activity
HW532_01515	COG0028	Belongs to the TPP enzyme family
HW532_01540	COG1414	Transcriptional regulator
HW532_01560	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW532_01565	COG0583	DNA-binding transcription factor activity
HW532_01600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_01625	COG0601	transmembrane transport
HW532_01630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_01640	COG1522	sequence-specific DNA binding
HW532_01650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_01655	COG0583	DNA-binding transcription factor activity
HW532_01680	COG1012	belongs to the aldehyde dehydrogenase family
HW532_01685	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_01685	COG1902	pentaerythritol trinitrate reductase activity
HW532_01700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW532_01710	COG0583	DNA-binding transcription factor activity
HW532_01715	COG2814	Major facilitator Superfamily
HW532_01720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HW532_01725	COG2814	Major facilitator Superfamily
HW532_01730	COG1733	regulation of RNA biosynthetic process
HW532_01760	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_01770	COG2079	MmgE PrpD family protein
HW532_01780	COG1686	Belongs to the peptidase S11 family
HW532_01785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW532_01795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW532_01800	COG0084	hydrolase, TatD family'
HW532_01805	COG0321	lipoyl(octanoyl) transferase activity
HW532_01805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW532_01815	COG3956	TIGRFAM MazG family protein
HW532_01820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW532_01825	COG1923	regulation of RNA biosynthetic process
HW532_01830	COG0569	domain protein
HW532_01835	COG2204	response regulator
HW532_01840	COG5000	phosphorelay sensor kinase activity
HW532_01845	COG2204	response regulator
HW532_01850	COG3852	Histidine kinase
HW532_01865	COG1058	Belongs to the CinA family
HW532_01865	COG1546	Belongs to the CinA family
HW532_01875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW532_01880	COG2261	transglycosylase associated protein
HW532_01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW532_01890	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW532_01895	COG0022	dehydrogenase e1 component
HW532_01895	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW532_01900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW532_01910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW532_01915	COG0247	lactate metabolic process
HW532_01925	COG0277	FAD linked oxidase domain protein
HW532_01930	COG0277	FAD linked oxidase domain protein
HW532_01940	COG0247	lactate metabolic process
HW532_01945	COG1139	Iron-sulfur cluster binding protein
HW532_01965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW532_01980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW532_01990	COG0513	Belongs to the DEAD box helicase family
HW532_02000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW532_02010	COG1960	acyl-CoA dehydrogenase activity
HW532_02015	COG0540	Belongs to the ATCase OTCase family
HW532_02020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW532_02025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW532_02030	COG0758	DNA mediated transformation
HW532_02040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW532_02045	COG0557	exoribonuclease II activity
HW532_02060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW532_02065	COG1012	belongs to the aldehyde dehydrogenase family
HW532_02075	COG0784	Response regulator, receiver
HW532_02090	COG1940	carbohydrate kinase activity
HW532_02095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW532_02105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW532_02110	COG0697	spore germination
HW532_02150	COG0537	adenosine 5'-monophosphoramidase activity
HW532_02170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HW532_02180	COG1686	Belongs to the peptidase S11 family
HW532_02185	COG0484	heat shock protein binding
HW532_02215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW532_02220	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HW532_02230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW532_02235	COG2226	methyltransferase
HW532_02250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_02260	COG0343	queuine tRNA-ribosyltransferase activity
HW532_02275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW532_02280	COG1126	abc transporter atp-binding protein
HW532_02285	COG0765	amino acid transport
HW532_02290	COG0765	amino acid transport
HW532_02295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW532_02300	COG1522	sequence-specific DNA binding
HW532_02305	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HW532_02310	COG1971	Probably functions as a manganese efflux pump
HW532_02320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW532_02345	COG0629	single-stranded DNA binding
HW532_02350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW532_02355	COG3264	Mechanosensitive ion channel
HW532_02355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HW532_02360	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW532_02385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW532_02390	COG1862	Preprotein translocase
HW532_02400	COG0625	glutathione transferase activity
HW532_02420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HW532_02425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HW532_02430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HW532_02435	COG0805	protein transport
HW532_02440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW532_02445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW532_02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW532_02475	COG0018	arginyl-trna synthetase
HW532_02480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HW532_02485	COG0316	Belongs to the HesB IscA family
HW532_02490	COG0583	DNA-binding transcription factor activity
HW532_02495	COG2814	Major facilitator Superfamily
HW532_02500	COG0667	Aldo Keto reductase
HW532_02515	COG0129	dihydroxy-acid dehydratase activity
HW532_02535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HW532_02550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW532_02555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW532_02555	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW532_02560	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW532_02615	COG1846	Transcriptional regulator
HW532_02645	COG0028	Belongs to the TPP enzyme family
HW532_02675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW532_02680	COG3791	Glutathione-dependent formaldehyde-activating
HW532_02685	COG2897	thiosulfate sulfurtransferase activity
HW532_02710	COG1126	abc transporter atp-binding protein
HW532_02715	COG0765	amino acid transport
HW532_02720	COG4597	amino acid ABC transporter
HW532_02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_02730	COG0626	cystathionine gamma-synthase activity
HW532_02735	COG3045	CreA protein
HW532_02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_02790	COG0444	Belongs to the ABC transporter superfamily
HW532_02795	COG4608	Belongs to the ABC transporter superfamily
HW532_02810	COG0477	Major facilitator Superfamily
HW532_02825	COG0667	Aldo Keto reductase
HW532_02830	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_02845	COG1741	Belongs to the pirin family
HW532_02850	COG0583	DNA-binding transcription factor activity
HW532_02855	COG1335	isochorismatase
HW532_02870	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_02870	COG1388	LysM domain
HW532_02910	COG1396	sequence-specific DNA binding
HW532_02925	COG0625	glutathione transferase activity
HW532_02945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW532_02950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_02955	COG4521	taurine ABC transporter
HW532_02960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW532_02965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW532_02975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_02990	COG4336	lyase activity
HW532_02995	COG0583	DNA-binding transcription factor activity
HW532_03005	COG1278	Cold shock
HW532_03010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW532_03015	COG0346	lactoylglutathione lyase activity
HW532_03020	COG2067	long-chain fatty acid transport protein
HW532_03055	COG1494	fructose-1,6-bisphosphatase
HW532_03065	COG0436	Aminotransferase
HW532_03075	COG0346	lactoylglutathione lyase activity
HW532_03080	COG1381	Involved in DNA repair and RecF pathway recombination
HW532_03085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW532_03090	COG0571	ribonuclease III activity
HW532_03100	COG0736	holo-[acyl-carrier-protein] synthase activity
HW532_03115	COG1758	RNA polymerase activity
HW532_03120	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_03120	COG1388	LysM domain
HW532_03135	COG1573	uracil-dna glycosylase
HW532_03140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW532_03145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW532_03155	COG0741	lytic transglycosylase activity
HW532_03160	COG0596	Alpha beta hydrolase
HW532_03160	COG2945	thiolester hydrolase activity
HW532_03190	COG0457	Tetratricopeptide repeat
HW532_03225	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_03225	COG1902	pentaerythritol trinitrate reductase activity
HW532_03230	COG0598	Magnesium transport protein CorA
HW532_03250	COG0492	ferredoxin-NADP+ reductase activity
HW532_03255	COG0633	Ferredoxin
HW532_03275	COG4948	Mandelate Racemase Muconate Lactonizing
HW532_03290	COG2814	Major facilitator Superfamily
HW532_03320	COG2326	polyphosphate kinase activity
HW532_03355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW532_03360	COG2329	Antibiotic biosynthesis monooxygenase
HW532_03380	COG0811	peptide transport
HW532_03400	COG4558	Periplasmic binding protein
HW532_03405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW532_03410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HW532_03415	COG1959	2 iron, 2 sulfur cluster binding
HW532_03545	COG0114	fumarate hydratase activity
HW532_03560	COG0277	FAD linked oxidase domain protein
HW532_03570	COG0038	chloride channel
HW532_03575	COG0210	DNA helicase
HW532_03590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_03595	COG0765	amino acid transport
HW532_03600	COG0028	Belongs to the TPP enzyme family
HW532_03615	COG2264	protein methyltransferase activity
HW532_03630	COG0006	proline dipeptidase activity
HW532_03650	COG0625	glutathione transferase activity
HW532_03675	COG0601	transmembrane transport
HW532_03680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_03690	COG2423	ornithine cyclodeaminase activity
HW532_03700	COG1177	transmembrane transport
HW532_03705	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_03715	COG3842	ATPase activity
HW532_03775	COG1280	lysine exporter protein (LysE YggA)
HW532_03780	COG0489	protein tyrosine kinase activity
HW532_03785	COG1414	Transcriptional regulator
HW532_03795	COG0154	amidase activity
HW532_03810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_03820	COG1573	uracil-dna glycosylase
HW532_03835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HW532_03840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HW532_03855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW532_03860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW532_03880	COG0372	Belongs to the citrate synthase family
HW532_03885	COG0596	Alpha beta hydrolase
HW532_03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_03905	COG0765	amino acid transport
HW532_03910	COG0765	amino acid transport
HW532_03915	COG1126	abc transporter atp-binding protein
HW532_03925	COG0517	IMP dehydrogenase activity
HW532_03940	COG1136	(ABC) transporter
HW532_03940	COG0577	efflux transmembrane transporter activity
HW532_03945	COG1136	(ABC) transporter
HW532_03945	COG0577	efflux transmembrane transporter activity
HW532_03950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_03955	COG0668	transmembrane transport
HW532_03970	COG3409	Peptidoglycan-binding domain 1 protein
HW532_03970	COG3773	Cell wall hydrolase
HW532_03985	COG3842	ATPase activity
HW532_03990	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_03995	COG1177	transmembrane transport
HW532_04020	COG0659	secondary active sulfate transmembrane transporter activity
HW532_04025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HW532_04035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW532_04040	COG0330	HflC and HflK could
HW532_04050	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_04060	COG3284	Transcriptional regulator
HW532_04070	COG0022	dehydrogenase e1 component
HW532_04075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW532_04080	COG0473	3-isopropylmalate dehydrogenase activity
HW532_04085	COG0308	aminopeptidase N
HW532_04095	COG2202	Pas domain
HW532_04095	COG2205	protein histidine kinase activity
HW532_04100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HW532_04105	COG2205	protein histidine kinase activity
HW532_04125	COG3088	subunit of a heme lyase
HW532_04130	COG1138	Cytochrome C-type biogenesis protein
HW532_04135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HW532_04140	COG4235	cytochrome complex assembly
HW532_04145	COG4235	cytochrome complex assembly
HW532_04150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_04160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW532_04160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_04170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW532_04285	COG4695	Portal protein
HW532_04300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HW532_04330	COG2166	iron-sulfur cluster assembly
HW532_04360	COG4957	zinc ion binding
HW532_04365	COG1320	monovalent cation:proton antiporter activity
HW532_04370	COG2212	antiporter activity
HW532_04375	COG1863	multisubunit Na H antiporter MnhE subunit
HW532_04380	COG0651	ATP synthesis coupled electron transport
HW532_04385	COG1006	Multisubunit Na H antiporter MnhC subunit
HW532_04390	COG2111	Na H antiporter
HW532_04395	COG2111	Na H antiporter
HW532_04395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW532_04405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW532_04420	COG1960	acyl-CoA dehydrogenase activity
HW532_04425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW532_04430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW532_04430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW532_04440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW532_04440	COG2010	Cytochrome c
HW532_04445	COG2358	TRAP transporter, solute receptor (TAXI family
HW532_04460	COG0433	COG0433 Predicted ATPase
HW532_04490	COG1703	isobutyryl-CoA mutase activity
HW532_04515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW532_04565	COG0640	Transcriptional regulator
HW532_04570	COG0477	Major facilitator Superfamily
HW532_04575	COG1115	amino acid carrier protein
HW532_04585	COG2885	chlorophyll binding
HW532_04635	COG0384	phenazine biosynthesis protein PhzF
HW532_04660	COG0028	Belongs to the TPP enzyme family
HW532_04680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW532_04685	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_04695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_04705	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_04710	COG0259	pyridoxamine-phosphate oxidase activity
HW532_04720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HW532_04725	COG0406	alpha-ribazole phosphatase activity
HW532_04730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW532_04735	COG2226	methyltransferase
HW532_04740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW532_04755	COG1960	acyl-CoA dehydrogenase activity
HW532_04760	COG0009	L-threonylcarbamoyladenylate synthase
HW532_04765	COG0277	FAD linked oxidase domain protein
HW532_04775	COG2135	peptidase activity
HW532_04795	COG0604	alcohol dehydrogenase
HW532_04810	COG0583	DNA-binding transcription factor activity
HW532_04815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW532_04825	COG0519	Catalyzes the synthesis of GMP from XMP
HW532_04830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HW532_04840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW532_04850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW532_04850	COG0574	Belongs to the PEP-utilizing enzyme family
HW532_04855	COG0751	glycine-tRNA ligase activity
HW532_04860	COG0752	glycyl-tRNA synthetase alpha subunit
HW532_04875	COG2890	protein-(glutamine-N5) methyltransferase activity
HW532_04885	COG0142	geranyltranstransferase activity
HW532_04895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HW532_04910	COG1573	uracil-dna glycosylase
HW532_04925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW532_04930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW532_04945	COG0628	permease
HW532_04955	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW532_04975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW532_04980	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HW532_04995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW532_05000	COG1196	nuclear chromosome segregation
HW532_05010	COG0356	it plays a direct role in the translocation of protons across the membrane
HW532_05015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW532_05020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW532_05030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW532_05035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW532_05040	COG0509	glycine decarboxylation via glycine cleavage system
HW532_05045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW532_05050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW532_05055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW532_05060	COG0328	RNA-DNA hybrid ribonuclease activity
HW532_05065	COG0678	peroxiredoxin activity
HW532_05075	COG1678	Uncharacterized ACR, COG1678
HW532_05085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW532_05090	COG0612	Peptidase, M16
HW532_05120	COG0109	protoheme IX farnesyltransferase activity
HW532_05125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW532_05130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW532_05140	COG0312	modulator of DNA gyrase
HW532_05155	COG0583	DNA-binding transcription factor activity
HW532_05170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HW532_05175	COG0312	modulator of DNA gyrase
HW532_05180	COG0483	inositol monophosphate 1-phosphatase activity
HW532_05190	COG0196	riboflavin kinase activity
HW532_05195	COG2030	dehydratase
HW532_05210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_05230	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_05245	COG3706	GGDEF domain
HW532_05255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW532_05260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW532_05265	COG0668	transmembrane transport
HW532_05305	COG2204	response regulator
HW532_05315	COG3108	Peptidase M15
HW532_05325	COG3750	Belongs to the UPF0335 family
HW532_05345	COG0469	pyruvate kinase activity
HW532_05350	COG0457	Tetratricopeptide repeat
HW532_05355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW532_05365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW532_05395	COG4264	IucA IucC family
HW532_05445	COG0071	Belongs to the small heat shock protein (HSP20) family
HW532_05465	COG0069	glutamate synthase activity
HW532_05465	COG0067	glutamate synthase
HW532_05465	COG0070	glutamate synthase
HW532_05485	COG2951	lytic endotransglycosylase activity
HW532_05500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW532_05515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW532_05535	COG1051	belongs to the nudix hydrolase family
HW532_05560	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_05585	COG1280	lysine exporter protein (LysE YggA)
HW532_05590	COG1522	sequence-specific DNA binding
HW532_05620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_05625	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW532_05630	COG0785	Cytochrome C biogenesis protein
HW532_05670	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HW532_05680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HW532_05685	COG1280	lysine exporter protein (LysE YggA)
HW532_05690	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_05700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HW532_05705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW532_05710	COG0181	hydroxymethylbilane synthase activity
HW532_05750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW532_05755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HW532_05765	COG3263	regulation of cellular component size
HW532_05770	COG2010	Cytochrome c
HW532_05785	COG4221	oxidoreductase activity
HW532_05810	COG1309	transcriptional regulator
HW532_05830	COG1872	DUF167
HW532_05835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HW532_05845	COG0069	glutamate synthase activity
HW532_05850	COG4175	Glycine betaine
HW532_05885	COG0137	argininosuccinate synthase activity
HW532_05895	COG1217	gtp-binding protein TYPA
HW532_05900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW532_05920	COG3339	Conserved Protein
HW532_05935	COG0405	Gamma-glutamyltransferase
HW532_05940	COG5001	Diguanylate cyclase
HW532_05940	COG1716	ATPase activity
HW532_05995	COG3214	Protein conserved in bacteria
HW532_06005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_06005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_06015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_06040	COG2884	Cell division ATP-binding protein ftsE
HW532_06065	COG0670	Belongs to the BI1 family
HW532_06075	COG4181	ATPase activity
HW532_06085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW532_06090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW532_06095	COG2154	pterin-4-alpha-carbinolamine dehydratase
HW532_06100	COG0596	Alpha beta hydrolase
HW532_06115	COG2086	electron transfer activity
HW532_06125	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_06135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW532_06140	COG0165	Argininosuccinate lyase
HW532_06150	COG0019	diaminopimelate decarboxylase activity
HW532_06165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW532_06180	COG4133	protoheme IX ABC transporter activity
HW532_06185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW532_06195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW532_06205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW532_06220	COG0552	protein localization to endoplasmic reticulum
HW532_06225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW532_06230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW532_06240	COG3706	GGDEF domain
HW532_06245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW532_06250	COG0228	four-way junction DNA binding
HW532_06255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW532_06260	COG0336	Belongs to the RNA methyltransferase TrmD family
HW532_06265	COG0335	large ribosomal subunit rRNA binding
HW532_06270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW532_06290	COG0066	3-isopropylmalate dehydratase activity
HW532_06295	COG0473	3-isopropylmalate dehydrogenase activity
HW532_06310	COG2814	Major facilitator Superfamily
HW532_06315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW532_06320	COG0589	response to stress
HW532_06325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_06330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_06335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_06350	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_06380	COG0729	surface antigen
HW532_06425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HW532_06430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW532_06435	COG4948	Mandelate Racemase Muconate Lactonizing
HW532_06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW532_06480	COG0174	glutamine synthetase
HW532_06515	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_06520	COG0183	Belongs to the thiolase family
HW532_06525	COG0697	spore germination
HW532_06545	COG0028	Belongs to the TPP enzyme family
HW532_06560	COG2204	response regulator
HW532_06575	COG0444	Belongs to the ABC transporter superfamily
HW532_06580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_06585	COG0601	transmembrane transport
HW532_06590	COG0747	negative chemotaxis
HW532_06615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_06625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HW532_06640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW532_06650	COG0129	dihydroxy-acid dehydratase activity
HW532_06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW532_06670	COG4143	(ABC) transporter
HW532_06680	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HW532_06700	COG0601	transmembrane transport
HW532_06710	COG0444	Belongs to the ABC transporter superfamily
HW532_06715	COG4608	Belongs to the ABC transporter superfamily
HW532_06720	COG0825	malonyl-CoA metabolic process
HW532_06725	COG4974	Belongs to the 'phage' integrase family
HW532_06730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW532_06735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW532_06740	COG4536	flavin adenine dinucleotide binding
HW532_06745	COG2814	Major facilitator Superfamily
HW532_06755	COG0271	Belongs to the BolA IbaG family
HW532_06795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW532_06805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW532_06830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_06835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_06840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_06845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_06860	COG1309	transcriptional regulator
HW532_06865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW532_06870	COG0569	domain protein
HW532_06875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_06880	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HW532_06895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW532_06895	COG1796	DNA polymerase
HW532_06905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW532_06910	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW532_06950	COG2186	Transcriptional regulator
HW532_06975	COG0683	leucine binding
HW532_06980	COG0410	ABC transporter
HW532_06985	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_06995	COG1335	isochorismatase
HW532_07005	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HW532_07005	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW532_07025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW532_07030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW532_07050	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_07055	COG0640	Transcriptional regulator
HW532_07065	COG1136	(ABC) transporter
HW532_07085	COG0531	amino acid
HW532_07090	COG5001	Diguanylate cyclase
HW532_07095	COG1024	Enoyl-CoA hydratase
HW532_07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_07110	COG1335	isochorismatase
HW532_07130	COG0395	ABC-type sugar transport system, permease component
HW532_07135	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_07145	COG1454	alcohol dehydrogenase
HW532_07145	COG1012	belongs to the aldehyde dehydrogenase family
HW532_07150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HW532_07160	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HW532_07170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HW532_07180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW532_07185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HW532_07190	COG3959	Transketolase, thiamine diphosphate binding domain
HW532_07205	COG4166	transmembrane transport
HW532_07210	COG0601	transmembrane transport
HW532_07215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_07225	COG4608	Belongs to the ABC transporter superfamily
HW532_07235	COG0583	DNA-binding transcription factor activity
HW532_07245	COG0596	Alpha beta hydrolase
HW532_07275	COG0583	DNA-binding transcription factor activity
HW532_07290	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_07295	COG0583	DNA-binding transcription factor activity
HW532_07305	COG3842	ATPase activity
HW532_07310	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_07315	COG4208	sulfate ABC transporter
HW532_07320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_07340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HW532_07345	COG0424	maF-like protein
HW532_07350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW532_07355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW532_07360	COG5328	Belongs to the UPF0262 family
HW532_07365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW532_07375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW532_07380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_07385	COG0174	glutamine synthetase
HW532_07390	COG0174	glutamine synthetase
HW532_07400	COG0405	Gamma-glutamyltransferase
HW532_07405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HW532_07410	COG0748	coenzyme F420 binding
HW532_07415	COG0745	RESPONSE REGULATOR receiver
HW532_07420	COG2205	protein histidine kinase activity
HW532_07430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW532_07430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW532_07435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW532_07455	COG2205	protein histidine kinase activity
HW532_07460	COG3178	'Phosphotransferase
HW532_07465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HW532_07475	COG1074	ATP-dependent DNA helicase activity
HW532_07500	COG0285	dihydrofolate synthase activity
HW532_07505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW532_07510	COG0159	tryptophan synthase activity
HW532_07515	COG0133	tryptophan synthase activity
HW532_07520	COG0135	phosphoribosylanthranilate isomerase activity
HW532_07525	COG0284	orotidine-5'-phosphate decarboxylase activity
HW532_07530	COG2423	ornithine cyclodeaminase activity
HW532_07540	COG0776	regulation of translation
HW532_07545	COG0616	signal peptide processing
HW532_07550	COG0539	negative regulation of cytoplasmic translation
HW532_07555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW532_07560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW532_07575	COG0488	(ABC) transporter
HW532_07590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW532_07595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW532_07600	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW532_07605	COG1137	ATPase activity
HW532_07635	COG1968	undecaprenyl-diphosphatase activity
HW532_07665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW532_07670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW532_07675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW532_07680	COG0072	phenylalanine-tRNA ligase activity
HW532_07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW532_07690	COG0730	response to heat
HW532_07695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW532_07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW532_07715	COG0045	succinate-CoA ligase (ADP-forming) activity
HW532_07720	COG0039	L-malate dehydrogenase activity
HW532_07725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW532_07750	COG1067	ATP-dependent peptidase activity
HW532_07770	COG2943	transferase activity, transferring hexosyl groups
HW532_07775	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HW532_07800	COG2022	thiamine diphosphate biosynthetic process
HW532_07815	COG2375	cellular response to nickel ion
HW532_07820	COG3246	L-lysine catabolic process to acetate
HW532_07830	COG1129	ABC transporter
HW532_07845	COG1802	Transcriptional regulator
HW532_07855	COG2169	Transcriptional regulator
HW532_07855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW532_07865	COG4206	TonB-dependent receptor
HW532_07880	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_07895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_07910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW532_07915	COG0129	dihydroxy-acid dehydratase activity
HW532_07920	COG3833	ABC-type maltose transport systems, permease component
HW532_07935	COG3842	ATPase activity
HW532_07945	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_07950	COG0045	succinate-CoA ligase (ADP-forming) activity
HW532_07950	COG1042	CoA-binding domain protein
HW532_07950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW532_07965	COG0583	DNA-binding transcription factor activity
HW532_07995	COG2010	Cytochrome c
HW532_08015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW532_08025	COG0071	Belongs to the small heat shock protein (HSP20) family
HW532_08030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW532_08035	COG0745	RESPONSE REGULATOR receiver
HW532_08040	COG4566	intracellular signal transduction
HW532_08045	COG4191	Histidine kinase
HW532_08050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_08055	COG4160	amino acid transport
HW532_08065	COG0765	amino acid transport
HW532_08075	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_08085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_08095	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_08105	COG0183	Belongs to the thiolase family
HW532_08110	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_08120	COG0431	NADPH-dependent FMN reductase
HW532_08125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW532_08130	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_08140	COG3842	ATPase activity
HW532_08145	COG1177	transmembrane transport
HW532_08150	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_08155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW532_08165	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_08205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW532_08220	COG0069	glutamate synthase activity
HW532_08245	COG0583	DNA-binding transcription factor activity
HW532_08260	COG0657	acetylesterase activity
HW532_08295	COG0583	DNA-binding transcription factor activity
HW532_08300	COG1024	Enoyl-CoA hydratase
HW532_08310	COG1802	Transcriptional regulator
HW532_08315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HW532_08320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_08330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_08330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_08340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_08345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_08355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_08365	COG2084	Dehydrogenase
HW532_08380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW532_08385	COG0747	negative chemotaxis
HW532_08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_08400	COG0444	Belongs to the ABC transporter superfamily
HW532_08405	COG4608	Belongs to the ABC transporter superfamily
HW532_08420	COG3711	transcriptional antiterminator
HW532_08420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW532_08435	COG4974	Belongs to the 'phage' integrase family
HW532_08465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HW532_08505	COG0667	Aldo Keto reductase
HW532_08545	COG5489	Protein of unknown function (DUF736)
HW532_08615	COG4962	Type ii secretion system protein e
HW532_08630	COG3451	type IV secretory pathway VirB4
HW532_08645	COG3846	protein secretion by the type IV secretion system
HW532_08650	COG3701	Conjugal transfer protein
HW532_08660	COG2948	multi-organism process
HW532_08670	COG0583	DNA-binding transcription factor activity
HW532_08685	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_08690	COG0583	DNA-binding transcription factor activity
HW532_08710	COG0492	ferredoxin-NADP+ reductase activity
HW532_08720	COG1280	lysine exporter protein (LysE YggA)
HW532_08740	COG0604	alcohol dehydrogenase
HW532_08740	COG3321	synthase
HW532_08745	COG0583	DNA-binding transcription factor activity
HW532_08755	COG1024	Enoyl-CoA hydratase
HW532_08775	COG4106	trans-aconitate 2-methyltransferase activity
HW532_08785	COG0583	DNA-binding transcription factor activity
HW532_08790	COG3321	synthase
HW532_08790	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_08790	COG0604	alcohol dehydrogenase
HW532_08795	COG0583	DNA-binding transcription factor activity
HW532_08810	COG0583	DNA-binding transcription factor activity
HW532_08840	COG0395	ABC-type sugar transport system, permease component
HW532_08845	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_08850	COG3842	ATPase activity
HW532_08860	COG0583	DNA-binding transcription factor activity
HW532_08885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW532_08890	COG1177	transmembrane transport
HW532_08900	COG3842	ATPase activity
HW532_08940	COG3842	ATPase activity
HW532_08945	COG1177	transmembrane transport
HW532_08960	COG1609	Transcriptional regulator
HW532_08970	COG0287	Prephenate dehydrogenase
HW532_08980	COG1850	ribulose-bisphosphate carboxylase activity
HW532_08990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_08995	COG0583	DNA-binding transcription factor activity
HW532_09010	COG0456	acetyltransferase
HW532_09015	COG0789	Transcriptional regulator
HW532_09025	COG2217	Heavy metal translocating P-type atpase
HW532_09045	COG2832	Protein of unknown function (DUF454)
HW532_09055	COG1764	response to oxidative stress
HW532_09065	COG1177	transmembrane transport
HW532_09080	COG3842	ATPase activity
HW532_09090	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_09105	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_09140	COG0668	transmembrane transport
HW532_09145	COG0583	DNA-binding transcription factor activity
HW532_09165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HW532_09170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_09195	COG1335	isochorismatase
HW532_09200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW532_09205	COG1116	anion transmembrane transporter activity
HW532_09210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW532_09220	COG1802	Transcriptional regulator
HW532_09225	COG3246	L-lysine catabolic process to acetate
HW532_09245	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_09255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW532_09275	COG0789	Transcriptional regulator
HW532_09280	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_09300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW532_09305	COG2207	Transcriptional regulator
HW532_09330	COG1132	(ABC) transporter
HW532_09340	COG1138	Cytochrome C-type biogenesis protein
HW532_09355	COG4172	Belongs to the ABC transporter superfamily
HW532_09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_09370	COG0747	negative chemotaxis
HW532_09375	COG1024	Enoyl-CoA hydratase
HW532_09385	COG1960	acyl-CoA dehydrogenase activity
HW532_09390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_09395	COG3246	L-lysine catabolic process to acetate
HW532_09410	COG0010	Belongs to the arginase family
HW532_09430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_09435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_09440	COG0601	transmembrane transport
HW532_09455	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_09475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_09480	COG4597	amino acid ABC transporter
HW532_09485	COG0765	amino acid transport
HW532_09490	COG1126	abc transporter atp-binding protein
HW532_09495	COG4221	oxidoreductase activity
HW532_09515	COG0251	oxidation-reduction process
HW532_09525	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_09535	COG0022	dehydrogenase e1 component
HW532_09540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW532_09565	COG3842	ATPase activity
HW532_09570	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_09575	COG1177	transmembrane transport
HW532_09580	COG0154	amidase activity
HW532_09610	COG1053	succinate dehydrogenase
HW532_09620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HW532_09645	COG0583	DNA-binding transcription factor activity
HW532_09650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_09655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_09660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_09665	COG0473	3-isopropylmalate dehydrogenase activity
HW532_09665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HW532_09675	COG0277	FAD linked oxidase domain protein
HW532_09680	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_09690	COG5002	protein histidine kinase activity
HW532_09710	COG0745	RESPONSE REGULATOR receiver
HW532_09715	COG1704	LemA family
HW532_09730	COG0420	3'-5' exonuclease activity
HW532_09735	COG4717	serine-type aminopeptidase activity
HW532_09750	COG0154	amidase activity
HW532_09760	COG4177	L-phenylalanine transmembrane transporter activity
HW532_09770	COG0410	ABC transporter
HW532_09780	COG4792	protein secretion
HW532_09795	COG4964	Belongs to the GSP D family
HW532_09800	COG4789	Type iii secretion
HW532_09855	COG1157	protein secretion by the type III secretion system
HW532_09865	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW532_09870	COG4790	Type iii secretion
HW532_09880	COG4791	protein targeting
HW532_09895	COG1802	Transcriptional regulator
HW532_09900	COG0028	Belongs to the TPP enzyme family
HW532_09925	COG0604	alcohol dehydrogenase
HW532_09930	COG1309	transcriptional regulator
HW532_09950	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_09960	COG0747	negative chemotaxis
HW532_09965	COG0601	transmembrane transport
HW532_09970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_09980	COG4608	Belongs to the ABC transporter superfamily
HW532_09985	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_10005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW532_10010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_10045	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HW532_10070	COG1414	Transcriptional regulator
HW532_10085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_10125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HW532_10130	COG0720	synthase
HW532_10135	COG0602	queuosine metabolic process
HW532_10155	COG0737	Belongs to the 5'-nucleotidase family
HW532_10165	COG1309	transcriptional regulator
HW532_10170	COG2080	2 iron, 2 sulfur cluster binding
HW532_10175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW532_10180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW532_10215	COG0444	Belongs to the ABC transporter superfamily
HW532_10220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_10225	COG0601	transmembrane transport
HW532_10230	COG2267	carboxylic ester hydrolase activity
HW532_10235	COG2197	response regulator
HW532_10240	COG2267	carboxylic ester hydrolase activity
HW532_10245	COG2226	methyltransferase
HW532_10285	COG0739	heme binding
HW532_10290	COG0542	response to heat
HW532_10305	COG2890	protein-(glutamine-N5) methyltransferase activity
HW532_10310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW532_10315	COG1426	Protein conserved in bacteria
HW532_10325	COG0527	aspartate kinase activity
HW532_10330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW532_10355	COG2226	methyltransferase
HW532_10360	COG0583	DNA-binding transcription factor activity
HW532_10370	COG0494	nUDIX hydrolase
HW532_10375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HW532_10380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW532_10385	COG0653	protein targeting
HW532_10390	COG3273	potassium ion transport
HW532_10390	COG0471	metal ion transport
HW532_10395	COG2132	Multicopper oxidase
HW532_10405	COG3034	peptidoglycan biosynthetic process
HW532_10410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW532_10430	COG2176	DNA-directed DNA polymerase activity
HW532_10440	COG4176	ABC-type proline glycine betaine transport system permease component
HW532_10445	COG0517	IMP dehydrogenase activity
HW532_10445	COG4175	Glycine betaine
HW532_10455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_10470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW532_10475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HW532_10490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW532_10490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW532_10505	COG0583	DNA-binding transcription factor activity
HW532_10525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW532_10535	COG0861	Integral membrane protein TerC family
HW532_10540	COG2235	arginine
HW532_10560	COG1024	Enoyl-CoA hydratase
HW532_10575	COG1280	lysine exporter protein (LysE YggA)
HW532_10585	COG2267	carboxylic ester hydrolase activity
HW532_10590	COG0183	Belongs to the thiolase family
HW532_10610	COG1960	acyl-CoA dehydrogenase activity
HW532_10615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW532_10640	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HW532_10655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW532_10675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW532_10695	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_10710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW532_10750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW532_10780	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW532_10785	COG1088	dTDP-glucose 4,6-dehydratase activity
HW532_10795	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HW532_10830	COG2010	Cytochrome c
HW532_10835	COG0251	oxidation-reduction process
HW532_10850	COG0640	Transcriptional regulator
HW532_10855	COG0142	geranyltranstransferase activity
HW532_10860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW532_10865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW532_10870	COG2095	MarC family integral membrane protein
HW532_10890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_10895	COG1012	belongs to the aldehyde dehydrogenase family
HW532_10900	COG1522	sequence-specific DNA binding
HW532_10905	COG2188	Transcriptional regulator
HW532_10910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW532_10915	COG2423	ornithine cyclodeaminase activity
HW532_10920	COG0006	proline dipeptidase activity
HW532_10925	COG3608	succinylglutamate desuccinylase aspartoacylase
HW532_10940	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_10950	COG1137	ATPase activity
HW532_10970	COG1121	(ABC) transporter
HW532_10975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW532_10980	COG1464	Belongs to the NlpA lipoprotein family
HW532_10985	COG2011	ABC-type metal ion transport system permease component
HW532_10990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW532_11005	COG1595	DNA-templated transcription, initiation
HW532_11030	COG2207	Transcriptional regulator
HW532_11035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW532_11065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HW532_11075	COG1228	amidohydrolase
HW532_11080	COG0402	S-adenosylhomocysteine deaminase activity
HW532_11085	COG2986	histidine ammonia-lyase
HW532_11090	COG0251	oxidation-reduction process
HW532_11100	COG1024	Enoyl-CoA hydratase
HW532_11105	COG1846	Transcriptional regulator
HW532_11110	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_11125	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_11165	COG4311	Sarcosine oxidase, delta subunit
HW532_11170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_11185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HW532_11190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW532_11205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW532_11210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW532_11220	COG1522	sequence-specific DNA binding
HW532_11225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW532_11235	COG3383	formate dehydrogenase (NAD+) activity
HW532_11240	COG2827	Endonuclease containing a URI domain
HW532_11265	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HW532_11270	COG0583	DNA-binding transcription factor activity
HW532_11290	COG3842	ATPase activity
HW532_11295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_11300	COG3246	L-lysine catabolic process to acetate
HW532_11310	COG1686	Belongs to the peptidase S11 family
HW532_11320	COG0523	cobalamin synthesis protein
HW532_11335	COG2264	protein methyltransferase activity
HW532_11340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW532_11345	COG1388	LysM domain
HW532_11345	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_11365	COG0746	molybdenum cofactor guanylyltransferase activity
HW532_11370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW532_11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_11385	COG2030	dehydratase
HW532_11405	COG0583	DNA-binding transcription factor activity
HW532_11425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_11435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_11435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_11440	COG4608	Belongs to the ABC transporter superfamily
HW532_11445	COG0444	Belongs to the ABC transporter superfamily
HW532_11455	COG0747	negative chemotaxis
HW532_11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_11465	COG0601	transmembrane transport
HW532_11475	COG0235	Class ii aldolase
HW532_11490	COG0303	'Molybdopterin
HW532_11495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW532_11500	COG2181	nitrate reductase activity
HW532_11505	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW532_11510	COG1140	nitrate reductase beta subunit
HW532_11515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW532_11520	COG2223	nitrite transmembrane transporter activity
HW532_11535	COG1522	sequence-specific DNA binding
HW532_11595	COG1024	Enoyl-CoA hydratase
HW532_11600	COG0514	ATP-dependent DNA helicase (RecQ)
HW532_11605	COG0598	Magnesium transport protein CorA
HW532_11615	COG2902	Dehydrogenase
HW532_11620	COG0138	bifunctional purine biosynthesis protein purh
HW532_11630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW532_11635	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW532_11640	COG4149	molybdate abc transporter
HW532_11660	COG0501	Belongs to the peptidase M48B family
HW532_11695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW532_11710	COG2855	membrane
HW532_11715	COG0583	DNA-binding transcription factor activity
HW532_11730	COG0300	oxidoreductase activity
HW532_11740	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_11745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HW532_11765	COG0747	negative chemotaxis
HW532_11770	COG0601	transmembrane transport
HW532_11775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_11780	COG0444	Belongs to the ABC transporter superfamily
HW532_11785	COG4608	Belongs to the ABC transporter superfamily
HW532_11795	COG0523	cobalamin synthesis protein
HW532_11805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW532_11805	COG3453	Protein conserved in bacteria
HW532_11840	COG4988	ABC transporter
HW532_11845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW532_11855	COG1294	oxidase, subunit
HW532_11875	COG0745	RESPONSE REGULATOR receiver
HW532_11900	COG2835	tetraacyldisaccharide 4'-kinase activity
HW532_11910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW532_11915	COG1946	Acyl-CoA thioesterase
HW532_11920	COG0347	Belongs to the P(II) protein family
HW532_11925	COG0004	ammonium transporteR
HW532_11935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HW532_11950	COG0495	leucyl-tRNA aminoacylation
HW532_11955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW532_11965	COG0745	RESPONSE REGULATOR receiver
HW532_11990	COG0357	Ribosomal RNA small subunit methyltransferase G
HW532_11995	COG0445	tRNA wobble uridine modification
HW532_12000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW532_12005	COG1331	Highly conserved protein containing a thioredoxin domain
HW532_12010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW532_12015	COG1981	membrane
HW532_12020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW532_12025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW532_12030	COG0424	maF-like protein
HW532_12035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW532_12040	COG0237	dephospho-CoA kinase activity
HW532_12045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW532_12050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HW532_12055	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW532_12075	COG1396	sequence-specific DNA binding
HW532_12080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HW532_12085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HW532_12090	COG0131	Imidazoleglycerol-phosphate dehydratase
HW532_12100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW532_12105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW532_12110	COG0107	imidazoleglycerol-phosphate synthase activity
HW532_12115	COG0140	phosphoribosyl-ATP diphosphatase activity
HW532_12120	COG1072	(Pantothenic acid kinase))
HW532_12130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW532_12135	COG2818	Glycosylase
HW532_12155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW532_12160	COG0756	dUTP diphosphatase activity
HW532_12165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW532_12175	COG2226	methyltransferase
HW532_12180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW532_12185	COG1024	Enoyl-CoA hydratase
HW532_12190	COG0268	Binds directly to 16S ribosomal RNA
HW532_12205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW532_12215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HW532_12220	COG2814	Major facilitator Superfamily
HW532_12235	COG1999	signal sequence binding
HW532_12265	COG1192	Involved in chromosome partitioning
HW532_12275	COG0484	heat shock protein binding
HW532_12280	COG0443	Heat shock 70 kDa protein
HW532_12310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW532_12320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW532_12325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW532_12335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW532_12340	COG0792	nuclease activity
HW532_12345	COG0189	ligase activity
HW532_12350	COG0606	chelatase, subunit chli
HW532_12365	COG0280	phosphate acetyltransferase
HW532_12365	COG0281	malic enzyme
HW532_12370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW532_12375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HW532_12380	COG0728	peptidoglycan biosynthetic process
HW532_12385	COG0180	Tryptophanyl-tRNA synthetase
HW532_12390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HW532_12395	COG0778	Nitroreductase
HW532_12400	COG1214	PFAM Peptidase M22, glycoprotease
HW532_12420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW532_12425	COG1702	phosphate starvation-inducible protein PhoH
HW532_12435	COG1253	flavin adenine dinucleotide binding
HW532_12440	COG1253	flavin adenine dinucleotide binding
HW532_12445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HW532_12450	COG1396	sequence-specific DNA binding
HW532_12455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW532_12460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW532_12465	COG0779	Required for maturation of 30S ribosomal subunits
HW532_12470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW532_12470	COG0195	Participates in both transcription termination and antitermination
HW532_12480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW532_12480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW532_12485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW532_12490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW532_12495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW532_12500	COG1185	polyribonucleotide nucleotidyltransferase activity
HW532_12505	COG0583	DNA-binding transcription factor activity
HW532_12515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HW532_12525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HW532_12565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HW532_12570	COG1845	cytochrome c oxidase, subunit III
HW532_12575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW532_12580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW532_12585	COG0531	amino acid
HW532_12590	COG1982	Orn Lys Arg decarboxylase major
HW532_12595	COG2235	arginine
HW532_12600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW532_12605	COG3755	Protein conserved in bacteria
HW532_12625	COG2135	peptidase activity
HW532_12665	COG1061	Type III restriction enzyme res subunit
HW532_12890	COG3191	aminopeptidase activity
HW532_12900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW532_12915	COG0481	GTPase activity
HW532_12920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_12930	COG0436	Aminotransferase
HW532_12935	COG2202	Pas domain
HW532_12935	COG2205	protein histidine kinase activity
HW532_12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_12955	COG1757	Na H antiporter
HW532_12960	COG1522	sequence-specific DNA binding
HW532_12970	COG1199	ATP-dependent helicase activity
HW532_12970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW532_12995	COG0534	Mate efflux family protein
HW532_13000	COG0534	Mate efflux family protein
HW532_13005	COG1201	RNA secondary structure unwinding
HW532_13030	COG1960	acyl-CoA dehydrogenase activity
HW532_13045	COG0432	Pfam Uncharacterised protein family UPF0047
HW532_13060	COG2204	response regulator
HW532_13065	COG0145	ligase activity
HW532_13070	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HW532_13075	COG4647	ligase activity
HW532_13105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW532_13120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW532_13135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW532_13140	COG0588	phosphoglycerate mutase activity
HW532_13150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW532_13160	COG4172	Belongs to the ABC transporter superfamily
HW532_13170	COG0747	negative chemotaxis
HW532_13180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_13200	COG1793	dna ligase
HW532_13200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW532_13205	COG1595	DNA-templated transcription, initiation
HW532_13215	COG5002	protein histidine kinase activity
HW532_13225	COG0573	inorganic phosphate transmembrane transporter activity
HW532_13235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW532_13245	COG0745	RESPONSE REGULATOR receiver
HW532_13255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW532_13260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW532_13275	COG2967	ApaG domain
HW532_13280	COG0717	Belongs to the dCTP deaminase family
HW532_13285	COG0662	Cupin 2, conserved barrel domain protein
HW532_13305	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_13315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW532_13325	COG0765	amino acid transport
HW532_13330	COG0765	amino acid transport
HW532_13345	COG3852	Histidine kinase
HW532_13355	COG0398	Pfam SNARE associated Golgi protein
HW532_13360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HW532_13365	COG0594	ribonuclease P activity
HW532_13370	COG0706	membrane insertase activity
HW532_13375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HW532_13390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW532_13415	COG0789	Transcriptional regulator
HW532_13420	COG0387	Pfam Sodium calcium exchanger
HW532_13430	COG0438	transferase activity, transferring glycosyl groups
HW532_13435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW532_13455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW532_13460	COG0697	spore germination
HW532_13465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_13470	COG0601	transmembrane transport
HW532_13475	COG4166	transmembrane transport
HW532_13505	COG0297	glycogen (starch) synthase activity
HW532_13525	COG1132	(ABC) transporter
HW532_13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW532_13530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW532_13540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_13555	COG1024	Enoyl-CoA hydratase
HW532_13560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_13560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_13570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_13575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW532_13580	COG0247	lactate metabolic process
HW532_13580	COG0277	FAD linked oxidase domain protein
HW532_13585	COG1802	Transcriptional regulator
HW532_13595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_13605	COG5598	trimethylamine methyltransferase
HW532_13615	COG4974	Belongs to the 'phage' integrase family
HW532_13620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW532_13635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW532_13645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW532_13650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW532_13655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW532_13670	COG0494	nUDIX hydrolase
HW532_13675	COG0793	Belongs to the peptidase S41A family
HW532_13685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HW532_13690	COG0799	negative regulation of ribosome biogenesis
HW532_13695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW532_13700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW532_13705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW532_13710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW532_13715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW532_13720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW532_13725	COG3743	rRNA binding
HW532_13725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW532_13745	COG0500	methyltransferase
HW532_13750	COG1802	Transcriptional regulator
HW532_13755	COG0444	Belongs to the ABC transporter superfamily
HW532_13760	COG4608	Belongs to the ABC transporter superfamily
HW532_13765	COG4166	transmembrane transport
HW532_13775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_13785	COG5002	protein histidine kinase activity
HW532_13815	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW532_13820	COG1129	ABC transporter
HW532_13835	COG0110	maltose O-acetyltransferase activity
HW532_13840	COG0438	transferase activity, transferring glycosyl groups
HW532_13845	COG2226	methyltransferase
HW532_13850	COG0438	transferase activity, transferring glycosyl groups
HW532_13880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW532_13895	COG0662	Cupin 2, conserved barrel domain protein
HW532_13895	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HW532_13900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW532_13935	COG1596	polysaccharide export
HW532_13940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW532_13945	COG0250	Participates in transcription elongation, termination and antitermination
HW532_13955	COG1063	alcohol dehydrogenase
HW532_13960	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_13965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW532_13970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_13970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_13990	COG1609	Transcriptional regulator
HW532_14020	COG1473	amidohydrolase
HW532_14025	COG0747	negative chemotaxis
HW532_14035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_14045	COG0531	amino acid
HW532_14050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW532_14060	COG1960	acyl-CoA dehydrogenase activity
HW532_14090	COG0640	Transcriptional regulator
HW532_14095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW532_14100	COG0436	Aminotransferase
HW532_14105	COG1910	domain protein
HW532_14135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW532_14140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW532_14145	COG0583	DNA-binding transcription factor activity
HW532_14150	COG0492	ferredoxin-NADP+ reductase activity
HW532_14155	COG1522	sequence-specific DNA binding
HW532_14170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW532_14180	COG3338	carbonate dehydratase activity
HW532_14185	COG0842	Transport permease protein
HW532_14190	COG1131	(ABC) transporter
HW532_14205	COG0583	DNA-binding transcription factor activity
HW532_14210	COG1741	Belongs to the pirin family
HW532_14230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW532_14250	COG3616	Alanine racemase, N-terminal domain
HW532_14275	COG0733	neurotransmitter:sodium symporter activity
HW532_14305	COG3795	YCII-related domain
HW532_14345	COG2860	membrane
HW532_14355	COG1960	acyl-CoA dehydrogenase activity
HW532_14360	COG0006	proline dipeptidase activity
HW532_14365	COG1473	amidohydrolase
HW532_14380	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_14385	COG3842	ATPase activity
HW532_14390	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HW532_14420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_14425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW532_14435	COG1522	sequence-specific DNA binding
HW532_14470	COG1473	amidohydrolase
HW532_14475	COG4166	transmembrane transport
HW532_14480	COG0601	transmembrane transport
HW532_14485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_14490	COG4172	Belongs to the ABC transporter superfamily
HW532_14495	COG4122	O-methyltransferase activity
HW532_14505	COG0741	lytic transglycosylase activity
HW532_14525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW532_14555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW532_14565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW532_14565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW532_14570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW532_14595	COG0747	negative chemotaxis
HW532_14600	COG0601	transmembrane transport
HW532_14605	COG0444	Belongs to the ABC transporter superfamily
HW532_14610	COG4608	Belongs to the ABC transporter superfamily
HW532_14615	COG1802	Transcriptional regulator
HW532_14630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HW532_14635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW532_14640	COG3639	organic phosphonate transmembrane transporter activity
HW532_14645	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HW532_14650	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HW532_14650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW532_14660	COG3454	Phosphonate metabolism
HW532_14665	COG4778	phosphonate C-P lyase system protein PhnL
HW532_14670	COG4107	phosphonate C-P lyase system protein PhnK
HW532_14675	COG3627	carbon phosphorus lyase activity
HW532_14680	COG3626	phosphonate metabolism
HW532_14685	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HW532_14690	COG3624	Phosphonate C-P lyase system protein PhnG
HW532_14700	COG2186	Transcriptional regulator
HW532_14710	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_14715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW532_14720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW532_14730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW532_14755	COG2171	N-acyltransferase activity
HW532_14765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW532_14775	COG0101	tRNA pseudouridine synthase activity
HW532_14780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW532_14785	COG0242	peptide deformylase activity
HW532_14800	COG2223	nitrite transmembrane transporter activity
HW532_14805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW532_14815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW532_14825	COG2816	NAD+ diphosphatase activity
HW532_14830	COG0077	Prephenate dehydratase
HW532_14830	COG1605	Chorismate mutase
HW532_14840	COG3474	cytochrome
HW532_14845	COG4166	transmembrane transport
HW532_14850	COG4166	transmembrane transport
HW532_14855	COG4174	ABC transporter (Permease)
HW532_14860	COG4239	(ABC) transporter, permease
HW532_14865	COG4172	Belongs to the ABC transporter superfamily
HW532_14870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW532_14890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW532_14935	COG1802	Transcriptional regulator
HW532_14940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_14965	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_14970	COG2890	protein-(glutamine-N5) methyltransferase activity
HW532_15060	COG1012	belongs to the aldehyde dehydrogenase family
HW532_15065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW532_15070	COG0626	cystathionine gamma-synthase activity
HW532_15075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_15080	COG4597	amino acid ABC transporter
HW532_15085	COG0765	amino acid transport
HW532_15090	COG1126	abc transporter atp-binding protein
HW532_15115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW532_15155	COG1215	transferase activity, transferring glycosyl groups
HW532_15165	COG2358	TRAP transporter, solute receptor (TAXI family
HW532_15175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_15185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW532_15200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW532_15205	COG0287	Prephenate dehydrogenase
HW532_15215	COG0604	alcohol dehydrogenase
HW532_15230	COG0254	rRNA binding
HW532_15235	COG1132	(ABC) transporter
HW532_15250	COG0483	inositol monophosphate 1-phosphatase activity
HW532_15255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW532_15265	COG0352	thiamine-phosphate diphosphorylase activity
HW532_15270	COG3588	fructose-bisphosphate aldolase
HW532_15275	COG0126	phosphoglycerate kinase activity
HW532_15305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW532_15310	COG1692	metallophosphoesterase
HW532_15315	COG0217	transcriptional regulatory protein
HW532_15335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HW532_15340	COG0632	four-way junction helicase activity
HW532_15345	COG2255	four-way junction helicase activity
HW532_15350	COG0824	Thioesterase
HW532_15370	COG0823	Involved in the tonB-independent uptake of proteins
HW532_15375	COG2885	chlorophyll binding
HW532_15385	COG0037	tRNA processing
HW532_15390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW532_15400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW532_15420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW532_15425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW532_15430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW532_15435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW532_15440	COG0583	DNA-binding transcription factor activity
HW532_15445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HW532_15485	COG0583	DNA-binding transcription factor activity
HW532_15490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW532_15495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW532_15500	COG0564	pseudouridine synthase activity
HW532_15525	COG1218	3'(2'),5'-bisphosphate nucleotidase
HW532_15550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW532_15560	COG0457	Tetratricopeptide repeat
HW532_15710	COG3941	tape measure
HW532_15725	COG4384	Bacteriophage Mu Gp45 protein
HW532_15730	COG4381	Mu-like prophage protein gp46
HW532_15735	COG3299	homolog of phage Mu protein gp47
HW532_15740	COG3778	Protein conserved in bacteria
HW532_15910	COG0482	sulfurtransferase activity
HW532_15930	COG0583	DNA-binding transcription factor activity
HW532_15945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW532_15950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_15955	COG0765	amino acid transport
HW532_15960	COG0765	amino acid transport
HW532_15965	COG0165	Argininosuccinate lyase
HW532_15970	COG1126	abc transporter atp-binding protein
HW532_15975	COG2207	Transcriptional regulator
HW532_15980	COG2223	nitrite transmembrane transporter activity
HW532_15990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW532_16000	COG0740	serine-type endopeptidase activity
HW532_16010	COG0640	Transcriptional regulator
HW532_16040	COG3842	ATPase activity
HW532_16045	COG1175	transmembrane transport
HW532_16050	COG0395	ABC-type sugar transport system, permease component
HW532_16060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HW532_16080	COG0450	alkyl hydroperoxide reductase
HW532_16090	COG1984	allophanate hydrolase subunit 2
HW532_16095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW532_16100	COG3665	Urea carboxylase-associated protein
HW532_16110	COG0765	amino acid transport
HW532_16120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW532_16130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW532_16150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW532_16155	COG4638	Rieske (2fe-2S)
HW532_16170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW532_16190	COG0583	DNA-binding transcription factor activity
HW532_16195	COG4608	Belongs to the ABC transporter superfamily
HW532_16200	COG0444	Belongs to the ABC transporter superfamily
HW532_16205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_16210	COG0601	transmembrane transport
HW532_16215	COG0747	negative chemotaxis
HW532_16225	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HW532_16240	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_16250	COG1335	isochorismatase
HW532_16265	COG4149	molybdate abc transporter
HW532_16315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW532_16325	COG4106	trans-aconitate 2-methyltransferase activity
HW532_16330	COG1999	signal sequence binding
HW532_16355	COG1120	ATPase activity
HW532_16365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW532_16380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HW532_16395	COG0277	FAD linked oxidase domain protein
HW532_16400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW532_16405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_16415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_16420	COG2186	Transcriptional regulator
HW532_16425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HW532_16430	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW532_16430	COG1902	pentaerythritol trinitrate reductase activity
HW532_16435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW532_16440	COG4533	DNA binding
HW532_16445	COG0601	transmembrane transport
HW532_16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_16455	COG0444	Belongs to the ABC transporter superfamily
HW532_16505	COG1215	transferase activity, transferring glycosyl groups
HW532_16505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HW532_16530	COG0747	negative chemotaxis
HW532_16535	COG0601	transmembrane transport
HW532_16540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_16620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_16625	COG0601	transmembrane transport
HW532_16630	COG0747	negative chemotaxis
HW532_16635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW532_16640	COG2188	Transcriptional regulator
HW532_16645	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_16665	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW532_16680	COG0625	glutathione transferase activity
HW532_16685	COG3327	negative regulation of DNA-templated transcription, initiation
HW532_16690	COG3396	Phenylacetate-CoA oxygenase
HW532_16695	COG3460	Phenylacetate-CoA oxygenase
HW532_16700	COG3396	Phenylacetate-CoA oxygenase
HW532_16705	COG2151	metal-sulfur cluster biosynthetic enzyme
HW532_16710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW532_16730	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_16735	COG0683	leucine binding
HW532_16740	COG1012	belongs to the aldehyde dehydrogenase family
HW532_16745	COG1024	Enoyl-CoA hydratase
HW532_16750	COG2050	protein possibly involved in aromatic compounds catabolism
HW532_16775	COG2951	lytic endotransglycosylase activity
HW532_16780	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_16785	COG0579	oxidoreductase
HW532_16790	COG1024	Enoyl-CoA hydratase
HW532_16795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW532_16800	COG1802	Transcriptional regulator
HW532_16825	COG2186	Transcriptional regulator
HW532_16840	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_16860	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_16880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW532_16885	COG0450	alkyl hydroperoxide reductase
HW532_16895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW532_16905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW532_16920	COG1597	lipid kinase activity
HW532_16945	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_16955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW532_16960	COG0156	8-amino-7-oxononanoate synthase activity
HW532_17005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW532_17005	COG1213	nucleotidyl transferase
HW532_17015	COG0456	acetyltransferase
HW532_17020	COG1132	(ABC) transporter
HW532_17030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW532_17040	COG0435	Glutathione S-transferase
HW532_17065	COG0714	Associated with various cellular activities
HW532_17090	COG0679	Auxin Efflux Carrier
HW532_17110	COG0530	calcium, potassium:sodium antiporter activity
HW532_17130	COG0745	RESPONSE REGULATOR receiver
HW532_17135	COG1846	Transcriptional regulator
HW532_17145	COG2989	Protein conserved in bacteria
HW532_17150	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_17170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW532_17175	COG0322	excinuclease ABC activity
HW532_17180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW532_17235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW532_17240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW532_17245	COG0193	aminoacyl-tRNA hydrolase activity
HW532_17250	COG0012	GTP binding
HW532_17270	COG0235	Class ii aldolase
HW532_17275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW532_17280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW532_17295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HW532_17300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW532_17300	COG2857	Cytochrome c1
HW532_17305	COG2857	Cytochrome c1
HW532_17305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW532_17310	COG0723	plastoquinol--plastocyanin reductase activity
HW532_17315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW532_17325	COG0408	coproporphyrinogen oxidase activity
HW532_17335	COG1132	(ABC) transporter
HW532_17350	COG2046	Belongs to the sulfate adenylyltransferase family
HW532_17350	COG0529	Catalyzes the synthesis of activated sulfate
HW532_17360	COG2130	NADP-dependent
HW532_17365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW532_17365	COG0519	Catalyzes the synthesis of GMP from XMP
HW532_17405	COG4669	(LipO)protein
HW532_17435	COG4790	Type iii secretion
HW532_17450	COG4792	protein secretion
HW532_17480	COG4789	Type iii secretion
HW532_17510	COG0583	DNA-binding transcription factor activity
HW532_17535	COG1278	Cold shock
HW532_17540	COG1278	Cold shock
HW532_17545	COG0556	nucleotide-excision repair
HW532_17565	COG0583	DNA-binding transcription factor activity
HW532_17575	COG2514	catechol 2,3-dioxygenase activity
HW532_17615	COG1175	transmembrane transport
HW532_17620	COG3833	ABC-type maltose transport systems, permease component
HW532_17635	COG0028	Belongs to the TPP enzyme family
HW532_17640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HW532_17665	COG4608	Belongs to the ABC transporter superfamily
HW532_17675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW532_17695	COG0697	spore germination
HW532_17705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HW532_17720	COG1797	cobyrinic acid a,c-diamide synthase activity
HW532_17815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW532_17820	COG0583	DNA-binding transcription factor activity
HW532_17835	COG1012	belongs to the aldehyde dehydrogenase family
HW532_17845	COG2207	Transcriptional regulator
HW532_17855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HW532_17860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW532_17865	COG0215	cysteine-tRNA ligase activity
HW532_17870	COG2852	Protein conserved in bacteria
HW532_17875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW532_17880	COG2962	Rard protein
HW532_17895	COG5265	(ABC) transporter
HW532_17900	COG0688	phosphatidylethanolamine metabolic process
HW532_17935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW532_17945	COG1657	PFAM Prenyltransferase squalene oxidase
HW532_17950	COG1233	COG1233 Phytoene dehydrogenase and related
HW532_17965	COG1562	ergosterol biosynthetic process
HW532_17970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HW532_17980	COG1562	ergosterol biosynthetic process
HW532_18005	COG1177	transmembrane transport
HW532_18010	COG3842	ATPase activity
HW532_18015	COG0010	Belongs to the arginase family
HW532_18035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW532_18040	COG0686	Belongs to the AlaDH PNT family
HW532_18045	COG0646	methionine synthase
HW532_18045	COG1410	methionine synthase
HW532_18050	COG5012	cobalamin binding
HW532_18070	COG5598	trimethylamine methyltransferase
HW532_18080	COG0646	methionine synthase
HW532_18080	COG1410	methionine synthase
HW532_18090	COG5598	trimethylamine methyltransferase
HW532_18105	COG3238	Protein conserved in bacteria
HW532_18115	COG1131	(ABC) transporter
HW532_18130	COG2373	Large extracellular alpha-helical protein
HW532_18165	COG0390	transport system, permease component
HW532_18170	COG1132	(ABC) transporter
HW532_18180	COG0625	glutathione transferase activity
HW532_18195	COG1012	belongs to the aldehyde dehydrogenase family
HW532_18215	COG3842	ATPase activity
HW532_18220	COG1177	transmembrane transport
HW532_18230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW532_18250	COG0174	glutamine synthetase
HW532_18255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_18295	COG0248	Ppx GppA phosphatase
HW532_18305	COG0477	Major facilitator Superfamily
HW532_18310	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW532_18315	COG1131	(ABC) transporter
HW532_18320	COG0842	Transport permease protein
HW532_18360	COG1475	DNA binding
HW532_18370	COG2801	Transposase and inactivated derivatives
HW532_18375	COG2842	Transposition protein
HW532_18385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW532_18470	COG4373	Mu-like prophage FluMu protein gp28
HW532_18475	COG4383	Mu-like prophage protein gp29
HW532_18480	COG2369	cell adhesion
HW532_18510	COG4397	Mu-like prophage major head subunit gpT
HW532_18570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_18615	COG3750	Belongs to the UPF0335 family
HW532_18645	COG0154	amidase activity
HW532_18650	COG2032	superoxide dismutase activity
HW532_18670	COG0519	Catalyzes the synthesis of GMP from XMP
HW532_18675	COG0583	DNA-binding transcription factor activity
HW532_18690	COG2070	2-Nitropropane dioxygenase
HW532_18695	COG1309	transcriptional regulator
HW532_18705	COG1393	Belongs to the ArsC family
HW532_18710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW532_18725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW532_18730	COG1802	Transcriptional regulator
HW532_18735	COG0683	leucine binding
HW532_18745	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW532_18780	COG1024	Enoyl-CoA hydratase
HW532_18790	COG3842	ATPase activity
HW532_18795	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW532_18850	COG1024	Enoyl-CoA hydratase
HW532_18860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW532_18865	COG0505	Belongs to the CarA family
HW532_18885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW532_18890	COG1802	Transcriptional regulator
HW532_18895	COG3842	ATPase activity
HW532_18910	COG0395	ABC-type sugar transport system, permease component
HW532_18915	COG1177	transmembrane transport
HW532_18920	COG1473	amidohydrolase
HW532_18930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW532_18935	COG0842	Transport permease protein
HW532_18935	COG1129	ABC transporter
HW532_18940	COG0842	Transport permease protein
HW532_18945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_18945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_18975	COG1475	DNA binding
HW532_18985	COG2801	Transposase and inactivated derivatives
HW532_18990	COG2842	Transposition protein
HW532_18995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW532_19065	COG4373	Mu-like prophage FluMu protein gp28
HW532_19070	COG4383	Mu-like prophage protein gp29
HW532_19110	COG4397	Mu-like prophage major head subunit gpT
HW532_19245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_19255	COG2186	Transcriptional regulator
HW532_19260	COG0277	FAD linked oxidase domain protein
HW532_19275	COG5507	3-demethylubiquinone-9 3-methyltransferase
HW532_19280	COG2010	Cytochrome c
HW532_19280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW532_19295	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW532_19300	COG1121	(ABC) transporter
HW532_19305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW532_19310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW532_19330	COG0405	Gamma-glutamyltransferase
HW532_19355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HW532_19365	COG1595	DNA-templated transcription, initiation
HW532_19370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW532_19380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW532_19385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HW532_19405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW532_19410	COG1160	GTP binding
HW532_19415	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_19420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW532_19440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW532_19445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW532_19450	COG0305	Participates in initiation and elongation during chromosome replication
HW532_19455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW532_19460	COG0359	binds to the 23S rRNA
HW532_19470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW532_19475	COG0360	Binds together with S18 to 16S ribosomal RNA
HW532_19485	COG2814	Major facilitator Superfamily
HW532_19490	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_19495	COG1309	transcriptional regulator
HW532_19500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW532_19510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW532_19515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW532_19520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW532_19525	COG1561	YicC-like family, N-terminal region
HW532_19530	COG0194	GDP metabolic process
HW532_19535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW532_19540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HW532_19555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HW532_19560	COG1473	amidohydrolase
HW532_19570	COG3842	ATPase activity
HW532_19585	COG1177	transmembrane transport
HW532_19605	COG1122	ATPase activity
HW532_19610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW532_19615	COG1268	BioY protein
HW532_19620	COG0318	PFAM AMP-dependent synthetase and ligase
HW532_19630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW532_19640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW532_19665	COG0488	(ABC) transporter
HW532_19670	COG0105	UTP biosynthetic process
HW532_19680	COG0243	molybdopterin cofactor binding
HW532_19685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HW532_19695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HW532_19705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW532_19715	COG0280	phosphate acetyltransferase
HW532_19715	COG0281	malic enzyme
HW532_19720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW532_19725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW532_19730	COG1376	ErfK ybiS ycfS ynhG family protein
HW532_19745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW532_19755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW532_19760	COG2226	methyltransferase
HW532_19770	COG0187	DNA topoisomerase II activity
HW532_19775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HW532_19785	COG0511	ligase activity, forming carbon-carbon bonds
HW532_19790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HW532_19805	COG0436	Aminotransferase
HW532_19810	COG1530	ribonuclease E activity
HW532_19815	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW532_19820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HW532_19840	COG0739	heme binding
HW532_19845	COG2833	Protein of unknown function (DUF455)
HW532_19850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW532_19860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW532_19865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HW532_19870	COG2945	thiolester hydrolase activity
HW532_19875	COG1959	2 iron, 2 sulfur cluster binding
HW532_19880	COG1104	cysteine desulfurase activity
HW532_19885	COG0719	Fe-S assembly protein
HW532_19890	COG0396	ATPase activity
HW532_19895	COG0719	Fe-S assembly protein
HW532_19900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW532_19905	COG2151	metal-sulfur cluster biosynthetic enzyme
HW532_19910	COG0316	Belongs to the HesB IscA family
HW532_19915	COG0513	Belongs to the DEAD box helicase family
HW532_19920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW532_19950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW532_19965	COG3383	formate dehydrogenase (NAD+) activity
HW532_19965	COG0243	molybdopterin cofactor binding
HW532_19970	COG0437	4 iron, 4 sulfur cluster binding
HW532_20035	COG0174	glutamine synthetase
HW532_20040	COG0347	Belongs to the P(II) protein family
HW532_20060	COG1247	-acetyltransferase
HW532_20075	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW532_20080	COG0740	serine-type endopeptidase activity
HW532_20085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW532_20090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW532_20095	COG0776	regulation of translation
HW532_20120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW532_20125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW532_20135	COG0649	NAD binding
HW532_20140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HW532_20145	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HW532_20155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW532_20165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW532_20175	COG0713	ATP synthesis coupled electron transport
HW532_20190	COG1007	ATP synthesis coupled electron transport
HW532_20205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW532_20215	COG3443	Belongs to the bacterial solute-binding protein 9 family
HW532_20220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW532_20230	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HW532_20235	COG0471	metal ion transport
HW532_20235	COG3273	potassium ion transport
HW532_20240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW532_20245	COG2084	Dehydrogenase
HW532_20250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW532_20270	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW532_20275	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW532_20280	COG2267	carboxylic ester hydrolase activity
HW532_20295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW532_20300	COG0626	cystathionine gamma-synthase activity
HW532_20305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HW532_20310	COG0330	HflC and HflK could
HW532_20315	COG0330	HflC and HflK could
HW532_20330	COG0625	glutathione transferase activity
HW532_20345	COG0546	phosphoglycolate phosphatase activity
HW532_20350	COG1012	belongs to the aldehyde dehydrogenase family
HW532_20355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HW532_20370	COG0166	Belongs to the GPI family
HW532_20375	COG0612	Peptidase, M16
HW532_20380	COG0612	Peptidase, M16
HW532_20390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW532_20395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW532_20400	COG0742	ribosomal rna small subunit methyltransferase
HW532_20410	COG0590	tRNA wobble adenosine to inosine editing
HW532_20425	COG0596	Alpha beta hydrolase
HW532_20435	COG1570	exodeoxyribonuclease VII activity
HW532_20440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW532_20445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW532_20455	COG5425	PFAM Usg family protein
HW532_20470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW532_20480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW532_20495	COG0583	DNA-binding transcription factor activity
HW532_20505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HW532_20510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW532_20515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HW532_20520	COG0625	glutathione transferase activity
HW532_20535	COG0667	Aldo Keto reductase
HW532_20540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HW532_20550	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW532_20555	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_20565	COG0275	rRNA processing
HW532_20580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW532_20585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW532_20590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW532_20595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW532_20610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW532_20615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW532_20620	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW532_20625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW532_20630	COG0849	cell division
HW532_20640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW532_20660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW532_20670	COG0113	porphobilinogen synthase activity
HW532_20680	COG1960	acyl-CoA dehydrogenase activity
HW532_20685	COG1024	Enoyl-CoA hydratase
HW532_20690	COG1993	acr, cog1993
HW532_20695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW532_20700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW532_20720	COG2989	Protein conserved in bacteria
HW532_20725	COG0156	8-amino-7-oxononanoate synthase activity
HW532_20730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HW532_20735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW532_20740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW532_20740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW532_20750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW532_20755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW532_20760	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW532_20765	COG2814	Major facilitator Superfamily
HW532_20770	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HW532_21005	COG0416	fatty acid biosynthetic process
HW532_21010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW532_21025	COG2721	sulfolactate sulfo-lyase activity
HW532_21030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW532_21035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW532_21040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW532_21045	COG1802	Transcriptional regulator
HW532_21050	COG1203	CRISPR-associated helicase, Cas3
HW532_21080	COG1518	maintenance of DNA repeat elements
HW532_21100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW532_21105	COG0297	glycogen (starch) synthase activity
HW532_21110	COG1596	polysaccharide export
HW532_21115	COG3206	protein involved in exopolysaccharide biosynthesis
HW532_21115	COG0489	protein tyrosine kinase activity
HW532_21140	COG1612	heme a metabolic process
HW532_21150	COG1024	Enoyl-CoA hydratase
HW532_21165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW532_21170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW532_21175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW532_21195	COG2801	Transposase and inactivated derivatives
HW532_21210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HW532_21215	COG0659	secondary active sulfate transmembrane transporter activity
HW532_21220	COG0589	response to stress
HW532_21255	COG2239	Acts as a magnesium transporter
HW532_21280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW532_21310	COG0175	sulfate reduction
HW532_21320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW532_21330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW532_21330	COG1648	precorrin-2 dehydrogenase activity
HW532_21335	COG1648	precorrin-2 dehydrogenase activity
HW532_21335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW532_21340	COG0633	Ferredoxin
HW532_21345	COG1396	sequence-specific DNA binding
HW532_21350	COG0625	glutathione transferase activity
HW532_21360	COG2202	Pas domain
HW532_21360	COG3920	Histidine kinase
HW532_21395	COG0783	Belongs to the Dps family
HW532_21410	COG0697	spore germination
HW532_21420	COG2264	protein methyltransferase activity
HW532_21425	COG0625	glutathione transferase activity
HW532_21435	COG0668	transmembrane transport
HW532_21455	COG3727	T/G mismatch-specific endonuclease activity
HW532_21470	COG3750	Belongs to the UPF0335 family
HW532_21590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_21600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_21605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW532_21615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HW532_21630	COG1278	Cold shock
HW532_21635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW532_21680	COG1271	oxidase subunit
HW532_21685	COG1028	Short-chain dehydrogenase reductase Sdr
HW532_21730	COG0501	Belongs to the peptidase M48B family
HW532_21735	COG3768	UPF0283 membrane protein
HW532_21740	COG3106	COG3106 Predicted ATPase
HW532_21750	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HW532_21760	COG0500	methyltransferase
HW532_21765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW532_21775	COG1230	cation diffusion facilitator family transporter
HW532_21800	COG4589	Belongs to the CDS family
HW532_21810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW532_21820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW532_21830	COG0538	isocitrate dehydrogenase activity
HW532_21835	COG0584	glycerophosphoryl diester phosphodiesterase
HW532_21850	COG0047	phosphoribosylformylglycinamidine synthase activity
HW532_21855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW532_21860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW532_21880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW532_21885	COG1414	Transcriptional regulator