locus-tag	class	description
D5400_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5400_00010	COG0592	DNA-directed DNA polymerase activity
D5400_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5400_00030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5400_00035	COG0756	dUTP diphosphatase activity
D5400_00060	COG2171	N-acyltransferase activity
D5400_00070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_00080	COG0431	NADPH-dependent FMN reductase
D5400_00115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5400_00125	COG0180	Tryptophanyl-tRNA synthetase
D5400_00140	COG1957	nucleoside hydrolase
D5400_00145	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_00155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5400_00160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5400_00170	COG1137	ATPase activity
D5400_00175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D5400_00185	COG0616	signal peptide processing
D5400_00190	COG0776	regulation of translation
D5400_00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_00220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_00225	COG0604	alcohol dehydrogenase
D5400_00250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5400_00255	COG1702	phosphate starvation-inducible protein PhoH
D5400_00260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5400_00265	COG4535	Mg2 and Co2 transporter CorC
D5400_00270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5400_00275	COG1396	sequence-specific DNA binding
D5400_00280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5400_00285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5400_00290	COG0837	glucose binding
D5400_00295	COG1803	Methylglyoxal synthase
D5400_00300	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D5400_00335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5400_00340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5400_00345	COG0280	phosphate acetyltransferase
D5400_00345	COG0281	malic enzyme
D5400_00350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5400_00355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5400_00365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_00370	COG0101	tRNA pseudouridine synthase activity
D5400_00375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5400_00380	COG0242	peptide deformylase activity
D5400_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_00395	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5400_00405	COG1420	regulation of RNA biosynthetic process
D5400_00410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5400_00420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5400_00425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5400_00430	COG3265	gluconokinase activity
D5400_00435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D5400_00440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5400_00475	COG4964	Belongs to the GSP D family
D5400_00510	COG2942	2-epimerase
D5400_00515	COG4702	Belongs to the UPF0303 family
D5400_00520	COG1940	carbohydrate kinase activity
D5400_00525	COG3842	ATPase activity
D5400_00530	COG0395	ABC-type sugar transport system, permease component
D5400_00540	COG1653	transport
D5400_00545	COG1609	Transcriptional regulator
D5400_00555	COG0729	surface antigen
D5400_00580	COG0187	DNA topoisomerase II activity
D5400_00595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5400_00605	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_00615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D5400_00625	COG1643	Atp-dependent helicase
D5400_00630	COG4136	ATPase activity
D5400_00635	COG4135	transport system, permease component
D5400_00640	COG4134	Bacterial extracellular solute-binding protein
D5400_00645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5400_00650	COG0706	membrane insertase activity
D5400_00655	COG0594	ribonuclease P activity
D5400_00660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5400_00675	COG4191	Histidine kinase
D5400_00745	COG0629	single-stranded DNA binding
D5400_00835	COG4959	Type IV secretory pathway protease TraF
D5400_00845	COG1196	nuclear chromosome segregation
D5400_00845	COG0739	heme binding
D5400_00845	COG0741	lytic transglycosylase activity
D5400_00865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_00875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5400_00880	COG0785	Cytochrome C biogenesis protein
D5400_00890	COG1914	H( )-stimulated, divalent metal cation uptake system
D5400_00900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5400_00905	COG2072	flavoprotein involved in K transport
D5400_00910	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_00915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_00925	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_00925	COG1388	LysM domain
D5400_00935	COG3034	peptidoglycan biosynthetic process
D5400_00970	COG2217	Heavy metal translocating P-type atpase
D5400_00980	COG1999	signal sequence binding
D5400_00995	COG1230	cation diffusion facilitator family transporter
D5400_01010	COG0745	RESPONSE REGULATOR receiver
D5400_01020	COG0789	Transcriptional regulator
D5400_01030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_01040	COG0741	lytic transglycosylase activity
D5400_01040	COG0739	heme binding
D5400_01040	COG1196	nuclear chromosome segregation
D5400_01055	COG1138	Cytochrome C-type biogenesis protein
D5400_01060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_01070	COG0583	DNA-binding transcription factor activity
D5400_01075	COG4962	Type ii secretion system protein e
D5400_01090	COG3451	type IV secretory pathway VirB4
D5400_01105	COG3846	protein secretion by the type IV secretion system
D5400_01120	COG2948	multi-organism process
D5400_01140	COG0464	growth
D5400_01180	COG2855	membrane
D5400_01185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_01200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5400_01220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_01230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5400_01235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_01255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_01260	COG0443	Heat shock 70 kDa protein
D5400_01265	COG0484	heat shock protein binding
D5400_01270	COG3963	phosphatidate phosphatase activity
D5400_01280	COG0284	orotidine-5'-phosphate decarboxylase activity
D5400_01295	COG1968	undecaprenyl-diphosphatase activity
D5400_01305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5400_01315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5400_01320	COG0840	transmembrane signaling receptor activity
D5400_01330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_01340	COG0747	negative chemotaxis
D5400_01345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_01360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5400_01365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5400_01385	COG2816	NAD+ diphosphatase activity
D5400_01395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5400_01400	COG3474	cytochrome
D5400_01405	COG4166	transmembrane transport
D5400_01415	COG4174	ABC transporter (Permease)
D5400_01420	COG4239	(ABC) transporter, permease
D5400_01435	COG4172	Belongs to the ABC transporter superfamily
D5400_01440	COG1051	belongs to the nudix hydrolase family
D5400_01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_01465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5400_01475	COG0481	GTPase activity
D5400_01485	COG3239	Fatty acid desaturase
D5400_01500	COG0765	amino acid transport
D5400_01505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_01510	COG1802	Transcriptional regulator
D5400_01515	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_01540	COG0697	spore germination
D5400_01550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_01550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_01565	COG1115	amino acid carrier protein
D5400_01600	COG1185	polyribonucleotide nucleotidyltransferase activity
D5400_01605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5400_01610	COG3920	Histidine kinase
D5400_01615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5400_01620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5400_01625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5400_01640	COG0779	Required for maturation of 30S ribosomal subunits
D5400_01645	COG1132	(ABC) transporter
D5400_01650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5400_01655	COG2900	Belongs to the SlyX family
D5400_01690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5400_01695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5400_01705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5400_01715	COG1012	belongs to the aldehyde dehydrogenase family
D5400_01720	COG0174	glutamine synthetase
D5400_01750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5400_01755	COG0792	nuclease activity
D5400_01760	COG0189	ligase activity
D5400_01765	COG0606	chelatase, subunit chli
D5400_01775	COG3186	Phenylalanine-4-hydroxylase
D5400_01780	COG1522	sequence-specific DNA binding
D5400_01785	COG1294	oxidase, subunit
D5400_01790	COG1271	oxidase subunit
D5400_01830	COG1902	pentaerythritol trinitrate reductase activity
D5400_01840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5400_01850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5400_01870	COG0072	phenylalanine-tRNA ligase activity
D5400_01870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_01885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_01905	COG0405	Gamma-glutamyltransferase
D5400_01915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5400_01930	COG0601	transmembrane transport
D5400_01935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_01940	COG0444	Belongs to the ABC transporter superfamily
D5400_01950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5400_01960	COG2197	response regulator
D5400_01965	COG3916	Acyl-homoserine-lactone synthase
D5400_01980	COG1272	protein, Hemolysin III
D5400_01985	COG2186	Transcriptional regulator
D5400_01995	COG0473	3-isopropylmalate dehydrogenase activity
D5400_02005	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_02040	COG0596	Alpha beta hydrolase
D5400_02045	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_02070	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_02075	COG3180	Ammonia monooxygenase
D5400_02080	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_02105	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D5400_02115	COG1960	acyl-CoA dehydrogenase activity
D5400_02120	COG2079	MmgE PrpD family protein
D5400_02130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5400_02140	COG0539	negative regulation of cytoplasmic translation
D5400_02145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5400_02150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5400_02170	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_02175	COG2186	Transcriptional regulator
D5400_02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_02190	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D5400_02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_02205	COG0730	response to heat
D5400_02210	COG0671	phosphoesterase, PA-phosphatase related
D5400_02215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5400_02225	COG0251	oxidation-reduction process
D5400_02250	COG1904	glucuronate isomerase
D5400_02255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_02260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D5400_02265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_02270	COG2942	2-epimerase
D5400_02275	COG1802	Transcriptional regulator
D5400_02280	COG1312	Catalyzes the dehydration of D-mannonate
D5400_02285	COG0246	Mannitol dehydrogenase
D5400_02290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_02295	COG0583	DNA-binding transcription factor activity
D5400_02300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5400_02305	COG2388	GCN5-related N-acetyl-transferase
D5400_02310	COG1741	Belongs to the pirin family
D5400_02335	COG3842	ATPase activity
D5400_02340	COG0395	ABC-type sugar transport system, permease component
D5400_02345	COG1175	transmembrane transport
D5400_02360	COG1177	transmembrane transport
D5400_02365	COG3842	ATPase activity
D5400_02370	COG0583	DNA-binding transcription factor activity
D5400_02375	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_02410	COG0133	tryptophan synthase activity
D5400_02415	COG0159	tryptophan synthase activity
D5400_02420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5400_02425	COG0285	dihydrofolate synthase activity
D5400_02435	COG1074	ATP-dependent DNA helicase activity
D5400_02440	COG2887	Belongs to the helicase family. UvrD subfamily
D5400_02445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5400_02450	COG3178	'Phosphotransferase
D5400_02455	COG2205	protein histidine kinase activity
D5400_02460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D5400_02470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5400_02470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5400_02480	COG2205	protein histidine kinase activity
D5400_02485	COG0745	RESPONSE REGULATOR receiver
D5400_02490	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5400_02500	COG3145	DNA-N1-methyladenine dioxygenase activity
D5400_02510	COG1072	(Pantothenic acid kinase))
D5400_02515	COG0140	phosphoribosyl-ATP diphosphatase activity
D5400_02520	COG0107	imidazoleglycerol-phosphate synthase activity
D5400_02525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5400_02530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5400_02540	COG0131	Imidazoleglycerol-phosphate dehydratase
D5400_02545	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D5400_02550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5400_02580	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5400_02585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5400_02590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5400_02595	COG0237	dephospho-CoA kinase activity
D5400_02600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5400_02605	COG0424	maF-like protein
D5400_02610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5400_02615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5400_02625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5400_02630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5400_02635	COG0445	tRNA wobble uridine modification
D5400_02640	COG0357	Ribosomal RNA small subunit methyltransferase G
D5400_02645	COG1192	Involved in chromosome partitioning
D5400_02650	COG1475	DNA binding
D5400_02665	COG0495	leucyl-tRNA aminoacylation
D5400_02670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5400_02690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5400_02690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5400_02695	COG0501	Belongs to the peptidase M48B family
D5400_02715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_02735	COG2902	Dehydrogenase
D5400_02755	COG0288	reversible hydration of carbon dioxide
D5400_02765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5400_02770	COG3214	Protein conserved in bacteria
D5400_02775	COG0473	3-isopropylmalate dehydrogenase activity
D5400_02780	COG0004	ammonium transporteR
D5400_02785	COG0347	Belongs to the P(II) protein family
D5400_02790	COG1946	Acyl-CoA thioesterase
D5400_02795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_02800	COG2835	tetraacyldisaccharide 4'-kinase activity
D5400_02805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_02825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5400_02825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5400_02830	COG0509	glycine decarboxylation via glycine cleavage system
D5400_02835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5400_02840	COG0840	transmembrane signaling receptor activity
D5400_02875	COG0066	3-isopropylmalate dehydratase activity
D5400_02885	COG1674	ftsk spoiiie
D5400_02890	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5400_02900	COG3932	Exopolysaccharide synthesis, ExoD
D5400_02915	COG0745	RESPONSE REGULATOR receiver
D5400_02925	COG2264	protein methyltransferase activity
D5400_02940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5400_02945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5400_02950	COG0181	hydroxymethylbilane synthase activity
D5400_02975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5400_02985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5400_02990	COG1247	-acetyltransferase
D5400_03000	COG0339	signal peptide processing
D5400_03010	COG2814	Major facilitator Superfamily
D5400_03015	COG0137	argininosuccinate synthase activity
D5400_03030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5400_03040	COG1595	DNA-templated transcription, initiation
D5400_03050	COG2154	pterin-4-alpha-carbinolamine dehydratase
D5400_03055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5400_03065	COG4181	ATPase activity
D5400_03070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5400_03075	COG0670	Belongs to the BI1 family
D5400_03095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5400_03100	COG4133	protoheme IX ABC transporter activity
D5400_03105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5400_03110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5400_03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_03130	COG3609	addiction module antidote protein, CC2985 family
D5400_03135	COG2917	probably involved in intracellular septation
D5400_03140	COG0552	protein localization to endoplasmic reticulum
D5400_03145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5400_03150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5400_03165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5400_03170	COG0287	Prephenate dehydrogenase
D5400_03170	COG1605	Chorismate mutase
D5400_03175	COG0228	four-way junction DNA binding
D5400_03180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5400_03185	COG0336	Belongs to the RNA methyltransferase TrmD family
D5400_03190	COG0335	large ribosomal subunit rRNA binding
D5400_03200	COG0765	amino acid transport
D5400_03205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5400_03210	COG3706	GGDEF domain
D5400_03255	COG1764	response to oxidative stress
D5400_03260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_03265	COG2845	Protein of unknown function (DUF459)
D5400_03270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D5400_03275	COG0039	L-malate dehydrogenase activity
D5400_03280	COG0045	succinate-CoA ligase (ADP-forming) activity
D5400_03290	COG0567	Dehydrogenase, E1 component
D5400_03295	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_03300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5400_03320	COG4974	Belongs to the 'phage' integrase family
D5400_03335	COG0642	Histidine kinase
D5400_03380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5400_03395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5400_03400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5400_03405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5400_03410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5400_03415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5400_03430	COG0793	Belongs to the peptidase S41A family
D5400_03445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5400_03450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5400_03455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5400_03460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5400_03465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5400_03470	COG0799	negative regulation of ribosome biogenesis
D5400_03485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5400_03490	COG3743	rRNA binding
D5400_03490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5400_03530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_03540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_03555	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_03575	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_03585	COG0835	chemotaxis
D5400_03590	COG0840	transmembrane signaling receptor activity
D5400_03600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_03605	COG4608	Belongs to the ABC transporter superfamily
D5400_03610	COG0444	Belongs to the ABC transporter superfamily
D5400_03615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_03620	COG0601	transmembrane transport
D5400_03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5400_03660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_03705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_03715	COG0235	Class ii aldolase
D5400_03720	COG0583	DNA-binding transcription factor activity
D5400_03725	COG0028	Belongs to the TPP enzyme family
D5400_03760	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_03770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_03775	COG0022	dehydrogenase e1 component
D5400_03775	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_03780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_03785	COG0022	dehydrogenase e1 component
D5400_03795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_03855	COG0438	transferase activity, transferring glycosyl groups
D5400_03865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5400_03880	COG0596	Alpha beta hydrolase
D5400_03895	COG0346	lactoylglutathione lyase activity
D5400_03905	COG1295	ribonuclease BN
D5400_03910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_03910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5400_03915	COG3842	ATPase activity
D5400_03980	COG0411	ABC transporter
D5400_04015	COG0535	radical SAM domain protein
D5400_04020	COG0535	radical SAM domain protein
D5400_04025	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D5400_04030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5400_04075	COG1131	(ABC) transporter
D5400_04085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D5400_04090	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5400_04125	COG2205	protein histidine kinase activity
D5400_04125	COG2202	Pas domain
D5400_04135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5400_04140	COG0583	DNA-binding transcription factor activity
D5400_04160	COG4993	Dehydrogenase
D5400_04175	COG0024	Methionine aminopeptidase
D5400_04180	COG0583	DNA-binding transcription factor activity
D5400_04200	COG0473	3-isopropylmalate dehydrogenase activity
D5400_04205	COG1053	succinate dehydrogenase
D5400_04240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D5400_04245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_04250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5400_04270	COG2081	HI0933 family
D5400_04275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5400_04280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_04325	COG2390	Transcriptional regulator
D5400_04335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5400_04340	COG3639	organic phosphonate transmembrane transporter activity
D5400_04380	COG1063	alcohol dehydrogenase
D5400_04390	COG3284	Transcriptional regulator
D5400_04400	COG1960	acyl-CoA dehydrogenase activity
D5400_04405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5400_04415	COG2217	Heavy metal translocating P-type atpase
D5400_04425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_04440	COG0726	polysaccharide deacetylase
D5400_04470	COG2094	Belongs to the DNA glycosylase MPG family
D5400_04530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_04535	COG0402	S-adenosylhomocysteine deaminase activity
D5400_04545	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5400_04575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D5400_04590	COG1329	Transcriptional regulator
D5400_04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5400_04630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5400_04635	COG2205	protein histidine kinase activity
D5400_04635	COG0784	Response regulator, receiver
D5400_04635	COG5002	protein histidine kinase activity
D5400_04640	COG0142	geranyltranstransferase activity
D5400_04645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5400_04650	COG0625	glutathione transferase activity
D5400_04655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5400_04705	COG2223	nitrite transmembrane transporter activity
D5400_04710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5400_04720	COG0693	protein deglycase activity
D5400_04760	COG0438	transferase activity, transferring glycosyl groups
D5400_04780	COG3459	Glycosyltransferase 36 associated
D5400_04820	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_04825	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_04830	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D5400_04840	COG0500	methyltransferase
D5400_04845	COG0142	geranyltranstransferase activity
D5400_04865	COG1562	ergosterol biosynthetic process
D5400_04870	COG1233	COG1233 Phytoene dehydrogenase and related
D5400_04880	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D5400_04890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5400_04915	COG1686	Belongs to the peptidase S11 family
D5400_04920	COG0523	cobalamin synthesis protein
D5400_04930	COG3034	peptidoglycan biosynthetic process
D5400_04935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5400_04940	COG0156	8-amino-7-oxononanoate synthase activity
D5400_04965	COG5002	protein histidine kinase activity
D5400_04965	COG0784	Response regulator, receiver
D5400_04975	COG1132	(ABC) transporter
D5400_04985	COG0156	8-amino-7-oxononanoate synthase activity
D5400_04995	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D5400_05030	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D5400_05035	COG1429	ligase activity, forming nitrogen-metal bonds
D5400_05040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_05045	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D5400_05065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5400_05070	COG2211	Major facilitator Superfamily
D5400_05075	COG0644	oxidoreductase
D5400_05085	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D5400_05100	COG0456	acetyltransferase
D5400_05105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5400_05110	COG1917	Cupin 2, conserved barrel domain protein
D5400_05115	COG0527	aspartate kinase activity
D5400_05120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5400_05145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5400_05150	COG2423	ornithine cyclodeaminase activity
D5400_05155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5400_05160	COG0006	proline dipeptidase activity
D5400_05180	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_05185	COG0418	dihydroorotase activity
D5400_05190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D5400_05210	COG0166	Belongs to the GPI family
D5400_05225	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_05235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5400_05240	COG0587	DNA-directed DNA polymerase activity
D5400_05280	COG2326	polyphosphate kinase activity
D5400_05285	COG5002	protein histidine kinase activity
D5400_05295	COG0573	inorganic phosphate transmembrane transporter activity
D5400_05305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5400_05310	COG0704	Plays a role in the regulation of phosphate uptake
D5400_05315	COG0745	RESPONSE REGULATOR receiver
D5400_05325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5400_05330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5400_05335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D5400_05345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_05350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_05355	COG2967	ApaG domain
D5400_05370	COG0717	Belongs to the dCTP deaminase family
D5400_05405	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D5400_05430	COG1024	Enoyl-CoA hydratase
D5400_05430	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_05435	COG0183	Belongs to the thiolase family
D5400_05440	COG1960	acyl-CoA dehydrogenase activity
D5400_05445	COG1960	acyl-CoA dehydrogenase activity
D5400_05460	COG0730	response to heat
D5400_05475	COG1201	RNA secondary structure unwinding
D5400_05480	COG2226	methyltransferase
D5400_05495	COG1793	dna ligase
D5400_05515	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5400_05520	COG0534	Mate efflux family protein
D5400_05525	COG0167	dihydroorotate dehydrogenase activity
D5400_05555	COG2198	Histidine kinase
D5400_05555	COG2205	protein histidine kinase activity
D5400_05555	COG0784	Response regulator, receiver
D5400_05560	COG1970	mechanosensitive ion channel activity
D5400_05580	COG2897	thiosulfate sulfurtransferase activity
D5400_05585	COG2391	methyltransferase activity
D5400_05600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_05620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5400_05635	COG5328	Belongs to the UPF0262 family
D5400_05645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5400_05650	COG0424	maF-like protein
D5400_05655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5400_05685	COG0840	transmembrane signaling receptor activity
D5400_05700	COG2198	Histidine kinase
D5400_05700	COG0643	Histidine kinase
D5400_05705	COG0835	chemotaxis
D5400_05710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5400_05715	COG2201	protein-glutamate methylesterase activity
D5400_05720	COG0745	RESPONSE REGULATOR receiver
D5400_05725	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5400_05735	COG1766	The M ring may be actively involved in energy transduction
D5400_05760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5400_05765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_05770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_05775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5400_05780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5400_05790	COG4786	Flagellar basal body rod
D5400_05795	COG1157	protein secretion by the type III secretion system
D5400_05805	COG1815	bacterial-type flagellum-dependent cell motility
D5400_05810	COG1558	bacterial-type flagellum-dependent cell motility
D5400_05815	COG1677	Flagellar hook-basal body complex protein FliE
D5400_05820	COG4786	Flagellar basal body rod
D5400_05825	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D5400_05830	COG1706	bacterial-type flagellum-dependent cell motility
D5400_05840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D5400_05850	COG1338	Plays a role in the flagellum-specific transport system
D5400_05855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_05860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5400_05870	COG2089	acid synthase
D5400_05885	COG1083	cytidylyl-transferase
D5400_05890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5400_05895	COG1086	Polysaccharide biosynthesis protein
D5400_05930	COG1749	Flagellar hook protein flgE
D5400_05950	COG5443	negative regulation of bacterial-type flagellum assembly
D5400_05955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5400_05960	COG4794	Type iii secretion
D5400_05965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5400_05995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5400_06000	COG1609	Transcriptional regulator
D5400_06010	COG1653	transport
D5400_06015	COG1175	transmembrane transport
D5400_06020	COG0395	ABC-type sugar transport system, permease component
D5400_06025	COG0366	Alpha amylase catalytic
D5400_06030	COG3842	ATPase activity
D5400_06035	COG0129	dihydroxy-acid dehydratase activity
D5400_06040	COG0363	glucosamine-6-phosphate deaminase activity
D5400_06045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5400_06050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_06055	COG0174	glutamine synthetase
D5400_06070	COG0840	transmembrane signaling receptor activity
D5400_06075	COG0671	phosphoesterase, PA-phosphatase related
D5400_06095	COG2224	Isocitrate lyase
D5400_06100	COG3800	Transcriptional regulator
D5400_06100	COG1396	sequence-specific DNA binding
D5400_06110	COG3842	ATPase activity
D5400_06115	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_06120	COG1177	transmembrane transport
D5400_06130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_06135	COG2205	protein histidine kinase activity
D5400_06165	COG0483	inositol monophosphate 1-phosphatase activity
D5400_06170	COG2089	acid synthase
D5400_06235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_06250	COG2111	Na H antiporter
D5400_06250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5400_06280	COG1320	monovalent cation:proton antiporter activity
D5400_06285	COG4191	Histidine kinase
D5400_06290	COG2204	response regulator
D5400_06295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5400_06305	COG4172	Belongs to the ABC transporter superfamily
D5400_06310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_06315	COG0601	transmembrane transport
D5400_06320	COG4166	transmembrane transport
D5400_06330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5400_06345	COG0475	glutathione-regulated potassium exporter activity
D5400_06345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5400_06350	COG2084	Dehydrogenase
D5400_06360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5400_06360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D5400_06365	COG3769	mannosylglycerate metabolic process
D5400_06370	COG1215	transferase activity, transferring glycosyl groups
D5400_06375	COG0366	Alpha amylase catalytic
D5400_06405	COG0640	Transcriptional regulator
D5400_06410	COG3453	Protein conserved in bacteria
D5400_06410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_06435	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_06445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_06485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5400_06490	COG1024	Enoyl-CoA hydratase
D5400_06495	COG1024	Enoyl-CoA hydratase
D5400_06495	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_06510	COG0625	glutathione transferase activity
D5400_06540	COG3416	Protein conserved in bacteria
D5400_06555	COG3909	cytochrome
D5400_06560	COG2197	response regulator
D5400_06565	COG4585	Histidine kinase
D5400_06575	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
D5400_06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5400_06645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5400_06650	COG1450	Type ii and iii secretion system protein
D5400_06660	COG4585	Histidine kinase
D5400_06665	COG2197	response regulator
D5400_06675	COG0420	3'-5' exonuclease activity
D5400_06680	COG4717	serine-type aminopeptidase activity
D5400_06685	COG3920	Histidine kinase
D5400_06690	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_06705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5400_06705	COG1017	nitric oxide dioxygenase activity
D5400_06715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5400_06740	COG0753	catalase activity
D5400_06745	COG1309	transcriptional regulator
D5400_06750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5400_06760	COG0783	Belongs to the Dps family
D5400_06765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_06775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_06785	COG1802	Transcriptional regulator
D5400_06795	COG0583	DNA-binding transcription factor activity
D5400_06805	COG1522	sequence-specific DNA binding
D5400_06815	COG1396	sequence-specific DNA binding
D5400_06815	COG3800	Transcriptional regulator
D5400_06820	COG0156	8-amino-7-oxononanoate synthase activity
D5400_06825	COG1063	alcohol dehydrogenase
D5400_06830	COG2072	flavoprotein involved in K transport
D5400_06850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5400_06855	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_06860	COG1177	transmembrane transport
D5400_06865	COG3842	ATPase activity
D5400_06875	COG2391	methyltransferase activity
D5400_06895	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5400_06915	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_06920	COG1177	transmembrane transport
D5400_06925	COG3842	ATPase activity
D5400_06955	COG3443	Belongs to the bacterial solute-binding protein 9 family
D5400_06965	COG0252	asparaginase activity
D5400_06970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_07000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5400_07005	COG1802	Transcriptional regulator
D5400_07010	COG1802	Transcriptional regulator
D5400_07015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_07025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_07030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5400_07050	COG4214	carbohydrate transport
D5400_07060	COG4213	ABC transporter substrate-binding protein
D5400_07065	COG3386	PFAM SMP-30 Gluconolaconase
D5400_07070	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_07075	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_07080	COG1129	ABC transporter
D5400_07085	COG1879	ABC-type sugar transport system periplasmic component
D5400_07110	COG2188	Transcriptional regulator
D5400_07115	COG3624	Phosphonate C-P lyase system protein PhnG
D5400_07120	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D5400_07125	COG3626	phosphonate metabolism
D5400_07130	COG3627	carbon phosphorus lyase activity
D5400_07135	COG4107	phosphonate C-P lyase system protein PhnK
D5400_07140	COG4778	phosphonate C-P lyase system protein PhnL
D5400_07150	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D5400_07155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5400_07160	COG3639	organic phosphonate transmembrane transporter activity
D5400_07165	COG3639	organic phosphonate transmembrane transporter activity
D5400_07175	COG3698	Phosphodiester glycosidase
D5400_07190	COG1162	GTPase activity
D5400_07195	COG3706	GGDEF domain
D5400_07205	COG0488	(ABC) transporter
D5400_07225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5400_07260	COG3300	MHYT domain
D5400_07260	COG5001	Diguanylate cyclase
D5400_07270	COG0402	S-adenosylhomocysteine deaminase activity
D5400_07285	COG1116	anion transmembrane transporter activity
D5400_07300	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D5400_07305	COG1309	transcriptional regulator
D5400_07310	COG0667	Aldo Keto reductase
D5400_07325	COG0673	inositol 2-dehydrogenase activity
D5400_07360	COG3842	ATPase activity
D5400_07365	COG1175	transmembrane transport
D5400_07370	COG0395	ABC-type sugar transport system, permease component
D5400_07385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5400_07395	COG3300	MHYT domain
D5400_07395	COG5001	Diguanylate cyclase
D5400_07405	COG0033	Phosphoglucomutase
D5400_07410	COG1959	2 iron, 2 sulfur cluster binding
D5400_07425	COG1435	thymidine kinase activity
D5400_07450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D5400_07465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5400_07465	COG0512	Glutamine amidotransferase of anthranilate synthase
D5400_07470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5400_07475	COG1960	acyl-CoA dehydrogenase activity
D5400_07480	COG1733	regulation of RNA biosynthetic process
D5400_07490	COG4721	ABC-type cobalt transport system, permease component
D5400_07495	COG1122	ATPase activity
D5400_07535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_07540	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_07540	COG0596	Alpha beta hydrolase
D5400_07560	COG0435	Glutathione S-transferase
D5400_07585	COG0714	Associated with various cellular activities
D5400_07600	COG0617	tRNA 3'-terminal CCA addition
D5400_07610	COG0408	coproporphyrinogen oxidase activity
D5400_07620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5400_07625	COG1132	(ABC) transporter
D5400_07630	COG1132	(ABC) transporter
D5400_07645	COG2857	Cytochrome c1
D5400_07645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5400_07650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5400_07665	COG0012	GTP binding
D5400_07670	COG0193	aminoacyl-tRNA hydrolase activity
D5400_07675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5400_07685	COG0129	dihydroxy-acid dehydratase activity
D5400_07690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5400_07715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5400_07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_07740	COG3706	GGDEF domain
D5400_07745	COG2205	protein histidine kinase activity
D5400_07750	COG0745	RESPONSE REGULATOR receiver
D5400_07755	COG1846	Transcriptional regulator
D5400_07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_07770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_07800	COG2200	EAL domain
D5400_07810	COG0583	DNA-binding transcription factor activity
D5400_07815	COG0492	ferredoxin-NADP+ reductase activity
D5400_07820	COG1522	sequence-specific DNA binding
D5400_07825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5400_07830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5400_07840	COG2321	neutral zinc metallopeptidase
D5400_07850	COG0505	Belongs to the CarA family
D5400_07870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5400_07875	COG1309	transcriptional regulator
D5400_07885	COG3706	GGDEF domain
D5400_07890	COG0432	Pfam Uncharacterised protein family UPF0047
D5400_07925	COG2207	Transcriptional regulator
D5400_07930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_07965	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5400_07970	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_07985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D5400_07990	COG4638	Rieske (2fe-2S)
D5400_08025	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_08055	COG2080	2 iron, 2 sulfur cluster binding
D5400_08060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D5400_08065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D5400_08085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_08100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5400_08110	COG1732	Glycine betaine
D5400_08115	COG1174	glycine betaine transport
D5400_08120	COG1125	glycine betaine transport
D5400_08125	COG1174	glycine betaine transport
D5400_08130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5400_08135	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D5400_08140	COG3454	Phosphonate metabolism
D5400_08150	COG3448	diguanylate cyclase activity
D5400_08150	COG4175	Glycine betaine
D5400_08165	COG1309	transcriptional regulator
D5400_08170	COG3119	arylsulfatase activity
D5400_08175	COG1012	belongs to the aldehyde dehydrogenase family
D5400_08180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D5400_08185	COG4154	Belongs to the RbsD FucU family
D5400_08195	COG0028	Belongs to the TPP enzyme family
D5400_08200	COG2267	carboxylic ester hydrolase activity
D5400_08235	COG0019	diaminopimelate decarboxylase activity
D5400_08255	COG2264	protein methyltransferase activity
D5400_08265	COG5001	Diguanylate cyclase
D5400_08285	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5400_08300	COG2001	Belongs to the MraZ family
D5400_08305	COG0275	rRNA processing
D5400_08320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5400_08330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5400_08335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5400_08345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5400_08350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5400_08355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5400_08360	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5400_08365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5400_08370	COG0849	cell division
D5400_08375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5400_08385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5400_08395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5400_08410	COG0006	proline dipeptidase activity
D5400_08415	COG2264	protein methyltransferase activity
D5400_08420	COG1999	signal sequence binding
D5400_08430	COG1012	belongs to the aldehyde dehydrogenase family
D5400_08450	COG4957	zinc ion binding
D5400_08460	COG0210	DNA helicase
D5400_08475	COG1404	Belongs to the peptidase S8 family
D5400_08480	COG0412	Dienelactone hydrolase
D5400_08490	COG1285	pathogenesis
D5400_08500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D5400_08530	COG0277	FAD linked oxidase domain protein
D5400_08570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5400_08580	COG0330	HflC and HflK could
D5400_08585	COG0330	HflC and HflK could
D5400_08600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5400_08605	COG3830	Belongs to the UPF0237 family
D5400_08605	COG0560	Phosphoserine phosphatase
D5400_08610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5400_08615	COG0745	RESPONSE REGULATOR receiver
D5400_08615	COG3706	GGDEF domain
D5400_08625	COG0028	Belongs to the TPP enzyme family
D5400_08630	COG0440	acetolactate synthase activity
D5400_08640	COG4423	Transcription factor
D5400_08645	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
D5400_08650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5400_08655	COG3239	Fatty acid desaturase
D5400_08660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D5400_08665	COG0859	PFAM glycosyl transferase family 9
D5400_08670	COG0859	PFAM glycosyl transferase family 9
D5400_08675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5400_08675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5400_08685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5400_08690	COG1846	Transcriptional regulator
D5400_08695	COG1764	response to oxidative stress
D5400_08700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_08705	COG0471	metal ion transport
D5400_08735	COG0384	phenazine biosynthesis protein PhzF
D5400_08775	COG0589	response to stress
D5400_08800	COG2323	membrane
D5400_08805	COG4325	translation initiation factor activity
D5400_08810	COG0659	secondary active sulfate transmembrane transporter activity
D5400_08815	COG1819	glycosyl
D5400_08840	COG1462	curli production assembly transport component CsgG
D5400_08880	COG1960	acyl-CoA dehydrogenase activity
D5400_08885	COG0583	DNA-binding transcription factor activity
D5400_08905	COG0438	transferase activity, transferring glycosyl groups
D5400_08910	COG0438	transferase activity, transferring glycosyl groups
D5400_08920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5400_08925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5400_08935	COG0667	Aldo Keto reductase
D5400_08965	COG1960	acyl-CoA dehydrogenase activity
D5400_08980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5400_09030	COG0583	DNA-binding transcription factor activity
D5400_09035	COG2871	sodium ion transport
D5400_09045	COG1410	methionine synthase
D5400_09045	COG0646	methionine synthase
D5400_09050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5400_09070	COG5012	cobalamin binding
D5400_09075	COG5598	trimethylamine methyltransferase
D5400_09080	COG0646	methionine synthase
D5400_09080	COG1410	methionine synthase
D5400_09100	COG3383	formate dehydrogenase (NAD+) activity
D5400_09105	COG1492	cobalamin metabolic process
D5400_09140	COG2133	pyrroloquinoline quinone binding
D5400_09225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5400_09235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_09245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5400_09250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D5400_09265	COG1598	PFAM Uncharacterised protein family UPF0150
D5400_09285	COG1309	transcriptional regulator
D5400_09315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_09320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_09340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_09360	COG0784	Response regulator, receiver
D5400_09365	COG3237	CsbD-like
D5400_09405	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_09425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5400_09435	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5400_09440	COG1686	Belongs to the peptidase S11 family
D5400_09460	COG3706	GGDEF domain
D5400_09465	COG3706	GGDEF domain
D5400_09465	COG5001	Diguanylate cyclase
D5400_09465	COG2203	Gaf domain
D5400_09465	COG4251	negative regulation of phosphorylation
D5400_09475	COG2948	multi-organism process
D5400_09490	COG3846	protein secretion by the type IV secretion system
D5400_09505	COG3451	type IV secretory pathway VirB4
D5400_09520	COG4962	Type ii secretion system protein e
D5400_09530	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_09540	COG2801	Transposase and inactivated derivatives
D5400_09580	COG0671	phosphoesterase, PA-phosphatase related
D5400_09655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_09740	COG2132	Multicopper oxidase
D5400_09745	COG1321	iron dependent repressor
D5400_09750	COG0789	Transcriptional regulator
D5400_09760	COG1999	signal sequence binding
D5400_09785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5400_09790	COG3034	peptidoglycan biosynthetic process
D5400_09800	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_09820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_09840	COG1230	cation diffusion facilitator family transporter
D5400_09850	COG2217	Heavy metal translocating P-type atpase
D5400_09865	COG2814	Major facilitator Superfamily
D5400_09905	COG2132	Multicopper oxidase
D5400_09930	COG0556	nucleotide-excision repair
D5400_09950	COG0133	tryptophan synthase activity
D5400_09985	COG4227	nucleotidyltransferase activity
D5400_10000	COG4974	Belongs to the 'phage' integrase family
D5400_10010	COG3622	Belongs to the hyi family
D5400_10015	COG0235	Class ii aldolase
D5400_10020	COG3395	kinase activity
D5400_10025	COG2084	Dehydrogenase
D5400_10030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5400_10050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_10055	COG2186	Transcriptional regulator
D5400_10060	COG1012	belongs to the aldehyde dehydrogenase family
D5400_10065	COG2186	Transcriptional regulator
D5400_10070	COG0287	Prephenate dehydrogenase
D5400_10075	COG1850	ribulose-bisphosphate carboxylase activity
D5400_10090	COG2111	Na H antiporter
D5400_10090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5400_10095	COG1006	Multisubunit Na H antiporter MnhC subunit
D5400_10100	COG0651	ATP synthesis coupled electron transport
D5400_10105	COG1863	multisubunit Na H antiporter MnhE subunit
D5400_10110	COG2212	antiporter activity
D5400_10115	COG1320	monovalent cation:proton antiporter activity
D5400_10135	COG0346	lactoylglutathione lyase activity
D5400_10145	COG1971	Probably functions as a manganese efflux pump
D5400_10165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_10195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_10200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5400_10205	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_10250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_10255	COG0459	protein refolding
D5400_10260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5400_10265	COG5425	PFAM Usg family protein
D5400_10270	COG1253	flavin adenine dinucleotide binding
D5400_10275	COG0534	Mate efflux family protein
D5400_10280	COG0829	nickel cation binding
D5400_10285	COG0831	urea catabolic process
D5400_10290	COG0832	Belongs to the urease beta subunit family
D5400_10300	COG0804	urea catabolic process
D5400_10315	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5400_10325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5400_10345	COG2308	Evidence 4 Homologs of previously reported genes of
D5400_10355	COG0513	Belongs to the DEAD box helicase family
D5400_10360	COG0683	leucine binding
D5400_10375	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_10390	COG2113	Glycine betaine
D5400_10395	COG4176	ABC-type proline glycine betaine transport system permease component
D5400_10405	COG3437	response regulator, receiver
D5400_10405	COG3850	Histidine kinase
D5400_10405	COG4999	Histidine kinase
D5400_10405	COG2205	protein histidine kinase activity
D5400_10410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_10410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D5400_10415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_10430	COG4266	Belongs to the allantoicase family
D5400_10435	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D5400_10440	COG2351	hydroxyisourate hydrolase activity
D5400_10445	COG0402	S-adenosylhomocysteine deaminase activity
D5400_10455	COG0583	DNA-binding transcription factor activity
D5400_10470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D5400_10485	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_10495	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_10505	COG0411	ABC transporter
D5400_10515	COG2032	superoxide dismutase activity
D5400_10530	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D5400_10560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_10570	COG0667	Aldo Keto reductase
D5400_10580	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D5400_10585	COG1121	(ABC) transporter
D5400_10590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_10595	COG0735	belongs to the Fur family
D5400_10600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5400_10605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5400_10615	COG1278	Cold shock
D5400_10630	COG2202	Pas domain
D5400_10630	COG2205	protein histidine kinase activity
D5400_10635	COG0625	glutathione transferase activity
D5400_10640	COG1573	uracil-dna glycosylase
D5400_10645	COG1522	sequence-specific DNA binding
D5400_10655	COG2084	Dehydrogenase
D5400_10665	COG0784	Response regulator, receiver
D5400_10665	COG4191	Histidine kinase
D5400_10670	COG0784	Response regulator, receiver
D5400_10675	COG3920	Histidine kinase
D5400_10690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_10695	COG0303	'Molybdopterin
D5400_10705	COG0746	molybdenum cofactor guanylyltransferase activity
D5400_10710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5400_10715	COG2814	Major facilitator Superfamily
D5400_10750	COG0556	nucleotide-excision repair
D5400_10770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D5400_10780	COG1607	acyl-coa hydrolase
D5400_10790	COG2203	Gaf domain
D5400_10790	COG4251	negative regulation of phosphorylation
D5400_10790	COG3706	GGDEF domain
D5400_10790	COG5001	Diguanylate cyclase
D5400_10805	COG0659	secondary active sulfate transmembrane transporter activity
D5400_10825	COG5507	3-demethylubiquinone-9 3-methyltransferase
D5400_10835	COG1278	Cold shock
D5400_10845	COG4941	Belongs to the sigma-70 factor family
D5400_10850	COG3795	YCII-related domain
D5400_10860	COG5285	phytanoyl-CoA dioxygenase
D5400_10865	COG0730	response to heat
D5400_10880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D5400_10885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D5400_10895	COG3384	dioxygenase
D5400_10900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5400_10920	COG0842	Transport permease protein
D5400_10925	COG1131	(ABC) transporter
D5400_10930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5400_10945	COG0280	phosphate acetyltransferase
D5400_10945	COG0281	malic enzyme
D5400_10950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_10960	COG2814	Major facilitator Superfamily
D5400_10965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5400_10970	COG1127	ABC transporter
D5400_10980	COG3218	ABC-type transport auxiliary lipoprotein component
D5400_10980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5400_10995	COG0633	Ferredoxin
D5400_11000	COG0492	ferredoxin-NADP+ reductase activity
D5400_11010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5400_11020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5400_11030	COG3768	UPF0283 membrane protein
D5400_11035	COG3106	COG3106 Predicted ATPase
D5400_11045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5400_11070	COG2885	chlorophyll binding
D5400_11080	COG2313	pseudouridylate synthase activity
D5400_11090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5400_11095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5400_11105	COG2066	Belongs to the glutaminase family
D5400_11120	COG0538	isocitrate dehydrogenase activity
D5400_11130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5400_11140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5400_11150	COG0037	tRNA processing
D5400_11155	COG2814	Major facilitator Superfamily
D5400_11160	COG2814	Major facilitator Superfamily
D5400_11175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5400_11200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5400_11205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5400_11230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5400_11240	COG3191	aminopeptidase activity
D5400_11250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5400_11255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_11270	COG3608	succinylglutamate desuccinylase aspartoacylase
D5400_11270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D5400_11290	COG0587	DNA-directed DNA polymerase activity
D5400_11300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5400_11305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5400_11320	COG4251	negative regulation of phosphorylation
D5400_11325	COG0784	Response regulator, receiver
D5400_11330	COG3920	Histidine kinase
D5400_11330	COG2202	Pas domain
D5400_11340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5400_11355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5400_11380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D5400_11385	COG1671	Belongs to the UPF0178 family
D5400_11390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5400_11415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D5400_11450	COG0679	Auxin Efflux Carrier
D5400_11455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5400_11460	COG1183	phosphatidylcholine synthase activity
D5400_11490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5400_11505	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5400_11510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5400_11515	COG0302	gtp cyclohydrolase
D5400_11525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5400_11530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5400_11545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5400_11550	COG2301	Belongs to the HpcH HpaI aldolase family
D5400_11565	COG0187	DNA topoisomerase II activity
D5400_11665	COG3750	Belongs to the UPF0335 family
D5400_11805	COG2076	Multidrug Resistance protein
D5400_11810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5400_11815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5400_11825	COG2945	thiolester hydrolase activity
D5400_11835	COG0719	Fe-S assembly protein
D5400_11840	COG0396	ATPase activity
D5400_11845	COG0719	Fe-S assembly protein
D5400_11850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5400_11855	COG2151	metal-sulfur cluster biosynthetic enzyme
D5400_11870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_11890	COG0513	Belongs to the DEAD box helicase family
D5400_11895	COG0739	heme binding
D5400_11900	COG2833	Protein of unknown function (DUF455)
D5400_11905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5400_11915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_11945	COG1136	(ABC) transporter
D5400_11960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5400_11980	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_12020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_12030	COG2188	Transcriptional regulator
D5400_12060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5400_12065	COG0066	3-isopropylmalate dehydratase activity
D5400_12085	COG1335	isochorismatase
D5400_12090	COG1053	succinate dehydrogenase
D5400_12100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5400_12120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5400_12125	COG0081	regulation of translation
D5400_12130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5400_12135	COG0222	ribosome binding
D5400_12140	COG0085	RNA polymerase activity
D5400_12145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5400_12155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5400_12160	COG0049	tRNA binding
D5400_12165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5400_12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5400_12180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5400_12185	COG0088	Forms part of the polypeptide exit tunnel
D5400_12190	COG0089	rRNA binding
D5400_12195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5400_12200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5400_12205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5400_12210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5400_12215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5400_12220	COG0255	Belongs to the universal ribosomal protein uL29 family
D5400_12225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5400_12230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5400_12235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5400_12240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5400_12245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5400_12250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5400_12255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5400_12260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5400_12265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5400_12270	COG1841	ribosomal large subunit assembly
D5400_12275	COG0200	Binds to the 23S rRNA
D5400_12285	COG0563	adenylate kinase activity
D5400_12290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5400_12295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5400_12300	COG0202	RNA polymerase activity
D5400_12305	COG0203	ribosomal protein L17
D5400_12325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5400_12335	COG0306	phosphate transporter
D5400_12345	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_12350	COG2207	Transcriptional regulator
D5400_12355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D5400_12360	COG1058	Belongs to the CinA family
D5400_12360	COG1546	Belongs to the CinA family
D5400_12390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5400_12400	COG3706	GGDEF domain
D5400_12405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5400_12405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5400_12410	COG2989	Protein conserved in bacteria
D5400_12415	COG0546	phosphoglycolate phosphatase activity
D5400_12420	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5400_12435	COG0439	Biotin carboxylase
D5400_12440	COG0321	lipoyl(octanoyl) transferase activity
D5400_12535	COG3750	Belongs to the UPF0335 family
D5400_12590	COG0616	signal peptide processing
D5400_12735	COG2239	Acts as a magnesium transporter
D5400_12750	COG0656	L-ascorbic acid biosynthetic process
D5400_12760	COG1760	l-serine dehydratase
D5400_12790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5400_12810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D5400_12810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5400_12820	COG3852	Histidine kinase
D5400_12825	COG2204	response regulator
D5400_12830	COG5000	phosphorelay sensor kinase activity
D5400_12835	COG2204	response regulator
D5400_12865	COG3842	ATPase activity
D5400_12870	COG0010	Belongs to the arginase family
D5400_12885	COG3795	YCII-related domain
D5400_12910	COG1686	Belongs to the peptidase S11 family
D5400_12915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5400_12925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5400_12930	COG0084	hydrolase, TatD family'
D5400_12935	COG0321	lipoyl(octanoyl) transferase activity
D5400_12935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5400_12945	COG3956	TIGRFAM MazG family protein
D5400_12950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5400_12955	COG1923	regulation of RNA biosynthetic process
D5400_12960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_12965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_12970	COG0569	domain protein
D5400_12985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5400_12990	COG0629	single-stranded DNA binding
D5400_12995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5400_13000	COG0625	glutathione transferase activity
D5400_13010	COG0347	Belongs to the P(II) protein family
D5400_13015	COG0174	glutamine synthetase
D5400_13025	COG0514	ATP-dependent DNA helicase (RecQ)
D5400_13035	COG1704	LemA family
D5400_13045	COG0668	transmembrane transport
D5400_13075	COG1960	acyl-CoA dehydrogenase activity
D5400_13090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5400_13100	COG1648	precorrin-2 dehydrogenase activity
D5400_13100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5400_13110	COG0343	queuine tRNA-ribosyltransferase activity
D5400_13115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5400_13125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5400_13130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5400_13135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5400_13140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5400_13145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_13150	COG3494	Protein of unknown function (DUF1009)
D5400_13155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_13160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5400_13165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5400_13170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5400_13175	COG0750	zinc metalloprotease
D5400_13185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5400_13190	COG0233	cytoplasmic translational termination
D5400_13195	COG0528	UMP kinase activity
D5400_13200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5400_13205	COG0052	Belongs to the universal ribosomal protein uS2 family
D5400_13210	COG2198	Histidine kinase
D5400_13210	COG5002	protein histidine kinase activity
D5400_13210	COG0784	Response regulator, receiver
D5400_13215	COG0784	Response regulator, receiver
D5400_13220	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D5400_13230	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D5400_13235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5400_13265	COG0537	adenosine 5'-monophosphoramidase activity
D5400_13270	COG2867	negative regulation of translational initiation
D5400_13275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5400_13285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5400_13295	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_13300	COG0022	dehydrogenase e1 component
D5400_13300	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5400_13305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5400_13340	COG0745	RESPONSE REGULATOR receiver
D5400_13350	COG0516	GMP reductase activity
D5400_13350	COG0517	IMP dehydrogenase activity
D5400_13385	COG1045	serine acetyltransferase
D5400_13410	COG1126	abc transporter atp-binding protein
D5400_13415	COG0765	amino acid transport
D5400_13420	COG4597	amino acid ABC transporter
D5400_13425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_13430	COG0626	cystathionine gamma-synthase activity
D5400_13445	COG0148	phosphopyruvate hydratase activity
D5400_13455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5400_13465	COG0504	CTP synthase activity
D5400_13475	COG0149	triose-phosphate isomerase activity
D5400_13480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_13485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5400_13490	COG0134	indole-3-glycerol-phosphate synthase activity
D5400_13500	COG0303	'Molybdopterin
D5400_13505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5400_13525	COG2095	MarC family integral membrane protein
D5400_13545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_13550	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5400_13555	COG1530	ribonuclease E activity
D5400_13555	COG1530	ribonuclease E activity
D5400_13560	COG0436	Aminotransferase
D5400_13575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5400_13580	COG0511	ligase activity, forming carbon-carbon bonds
D5400_13590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5400_13615	COG3243	poly(R)-hydroxyalkanoic acid synthase
D5400_13620	COG1489	DNA binding
D5400_13625	COG0024	Methionine aminopeptidase
D5400_13630	COG2003	Belongs to the UPF0758 family
D5400_13635	COG3046	protein related to deoxyribodipyrimidine photolyase
D5400_13640	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5400_13665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D5400_13715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5400_13720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5400_13725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5400_13730	COG0805	protein transport
D5400_13735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5400_13740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5400_13745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5400_13750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5400_13755	COG1472	Belongs to the glycosyl hydrolase 3 family
D5400_13765	COG0018	arginyl-trna synthetase
D5400_13770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D5400_13785	COG0708	Exodeoxyribonuclease III
D5400_13795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D5400_13800	COG0129	dihydroxy-acid dehydratase activity
D5400_13810	COG0525	valine-tRNA ligase activity
D5400_13825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5400_13835	COG0850	regulation of cytokinetic process
D5400_13845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5400_13865	COG0415	Belongs to the DNA photolyase family
D5400_13880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5400_13885	COG2211	Major facilitator Superfamily
D5400_13890	COG4221	oxidoreductase activity
D5400_13895	COG3806	Anti-sigma factor
D5400_13900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5400_13910	COG2897	thiosulfate sulfurtransferase activity
D5400_13920	COG0686	Belongs to the AlaDH PNT family
D5400_13925	COG1522	sequence-specific DNA binding
D5400_13930	COG2814	Major facilitator Superfamily
D5400_13940	COG0737	Belongs to the 5'-nucleotidase family
D5400_13945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5400_13950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D5400_13955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5400_13965	COG0785	Cytochrome C biogenesis protein
D5400_14185	COG3750	Belongs to the UPF0335 family
D5400_14300	COG2199	diguanylate cyclase activity
D5400_14300	COG2200	EAL domain
D5400_14300	COG2203	Gaf domain
D5400_14310	COG1278	Cold shock
D5400_14315	COG0346	lactoylglutathione lyase activity
D5400_14330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5400_14340	COG0436	Aminotransferase
D5400_14350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5400_14360	COG0154	amidase activity
D5400_14370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5400_14375	COG5001	Diguanylate cyclase
D5400_14375	COG3300	MHYT domain
D5400_14380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5400_14385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5400_14405	COG1960	acyl-CoA dehydrogenase activity
D5400_14410	COG0540	Belongs to the ATCase OTCase family
D5400_14425	COG0758	DNA mediated transformation
D5400_14435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5400_14440	COG0557	exoribonuclease II activity
D5400_14465	COG3706	GGDEF domain
D5400_14465	COG0745	RESPONSE REGULATOR receiver
D5400_14470	COG0784	Response regulator, receiver
D5400_14485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5400_14500	COG1136	(ABC) transporter
D5400_14510	COG0442	prolyl-tRNA aminoacylation
D5400_14535	COG1007	ATP synthesis coupled electron transport
D5400_14550	COG0713	ATP synthesis coupled electron transport
D5400_14560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_14565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5400_14580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5400_14585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D5400_14595	COG0649	NAD binding
D5400_14600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_14605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_14610	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5400_14635	COG0247	lactate metabolic process
D5400_14645	COG0277	FAD linked oxidase domain protein
D5400_14650	COG0277	FAD linked oxidase domain protein
D5400_14655	COG0583	DNA-binding transcription factor activity
D5400_14665	COG2186	Transcriptional regulator
D5400_14670	COG0247	lactate metabolic process
D5400_14675	COG1139	Iron-sulfur cluster binding protein
D5400_14680	COG1556	Lactate utilization protein
D5400_14715	COG0583	DNA-binding transcription factor activity
D5400_14720	COG1570	exodeoxyribonuclease VII activity
D5400_14725	COG2354	Protein conserved in bacteria
D5400_14735	COG4948	Mandelate Racemase Muconate Lactonizing
D5400_14740	COG0747	negative chemotaxis
D5400_14745	COG0601	transmembrane transport
D5400_14750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5400_14755	COG0444	Belongs to the ABC transporter superfamily
D5400_14760	COG4608	Belongs to the ABC transporter superfamily
D5400_14765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D5400_14770	COG4187	Peptidase family M20/M25/M40
D5400_14775	COG0776	regulation of translation
D5400_14780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5400_14785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5400_14790	COG0740	serine-type endopeptidase activity
D5400_14800	COG2124	cytochrome p450
D5400_14815	COG1832	CoA-binding protein
D5400_14825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_14830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_14830	COG1116	anion transmembrane transporter activity
D5400_14835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_14845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5400_14850	COG1024	Enoyl-CoA hydratase
D5400_14860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5400_14865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5400_14875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5400_14880	COG1612	heme a metabolic process
D5400_14925	COG0667	Aldo Keto reductase
D5400_14945	COG0776	regulation of translation
D5400_14950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5400_14955	COG0416	fatty acid biosynthetic process
D5400_14975	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5400_14980	COG2814	Major facilitator Superfamily
D5400_14985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5400_14990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5400_15000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5400_15000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5400_15005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5400_15010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5400_15015	COG2207	Transcriptional regulator
D5400_15030	COG2989	Protein conserved in bacteria
D5400_15045	COG0113	porphobilinogen synthase activity
D5400_15055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D5400_15065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5400_15075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5400_15080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5400_15085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D5400_15100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D5400_15110	COG0628	permease
D5400_15115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5400_15120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5400_15125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5400_15130	COG0243	molybdopterin cofactor binding
D5400_15135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D5400_15150	COG0625	glutathione transferase activity
D5400_15165	COG0322	excinuclease ABC activity
D5400_15175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5400_15185	COG0314	molybdopterin synthase activity
D5400_15190	COG0175	sulfate reduction
D5400_15195	COG0105	UTP biosynthetic process
D5400_15225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5400_15240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5400_15250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5400_15255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5400_15260	COG0194	GDP metabolic process
D5400_15265	COG1561	YicC-like family, N-terminal region
D5400_15270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5400_15275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5400_15280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5400_15290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5400_15300	COG0360	Binds together with S18 to 16S ribosomal RNA
D5400_15315	COG0359	binds to the 23S rRNA
D5400_15320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5400_15330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5400_15345	COG3609	addiction module antidote protein, CC2985 family
D5400_15370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5400_15375	COG4221	oxidoreductase activity
D5400_15380	COG1183	phosphatidylcholine synthase activity
D5400_15385	COG0688	phosphatidylethanolamine metabolic process
D5400_15390	COG5265	(ABC) transporter
D5400_15410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5400_15410	COG3153	acetyltransferase
D5400_15425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_15445	COG0215	cysteine-tRNA ligase activity
D5400_15470	COG0494	nUDIX hydrolase
D5400_15490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5400_15510	COG1595	DNA-templated transcription, initiation
D5400_15525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5400_15530	COG1388	LysM domain
D5400_15530	COG3409	Peptidoglycan-binding domain 1 protein
D5400_15530	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5400_15535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5400_15555	COG1381	Involved in DNA repair and RecF pathway recombination
D5400_15560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5400_15565	COG0571	ribonuclease III activity
D5400_15570	COG0681	Belongs to the peptidase S26 family
D5400_15575	COG0736	holo-[acyl-carrier-protein] synthase activity
D5400_15590	COG1758	RNA polymerase activity
D5400_15600	COG1573	uracil-dna glycosylase
D5400_15615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5400_15620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5400_15625	COG0741	lytic transglycosylase activity
D5400_15640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5400_15645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5400_15670	COG0811	peptide transport
D5400_15690	COG1132	(ABC) transporter
D5400_15725	COG0156	8-amino-7-oxononanoate synthase activity
D5400_15750	COG1091	dTDP-4-dehydrorhamnose reductase activity
D5400_15790	COG0438	transferase activity, transferring glycosyl groups
D5400_15790	COG1216	Glycosyl transferase, family 2
D5400_15800	COG4221	oxidoreductase activity
D5400_15890	COG1061	Type III restriction enzyme res subunit
D5400_15925	COG1475	DNA binding
D5400_16075	COG3453	Protein conserved in bacteria
D5400_16075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_16080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_16080	COG3453	Protein conserved in bacteria
D5400_16095	COG0745	RESPONSE REGULATOR receiver
D5400_16100	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_16105	COG4232	protein-disulfide reductase activity
D5400_16110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_16140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_16145	COG1116	anion transmembrane transporter activity
D5400_16150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_16155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5400_16160	COG2011	ABC-type metal ion transport system permease component
D5400_16170	COG0431	NADPH-dependent FMN reductase
D5400_16190	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D5400_16195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_16205	COG1959	2 iron, 2 sulfur cluster binding
D5400_16215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5400_16225	COG3206	protein involved in exopolysaccharide biosynthesis
D5400_16225	COG0489	protein tyrosine kinase activity
D5400_16230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5400_16235	COG1215	transferase activity, transferring glycosyl groups
D5400_16240	COG1215	transferase activity, transferring glycosyl groups
D5400_16245	COG1215	transferase activity, transferring glycosyl groups
D5400_16250	COG0438	transferase activity, transferring glycosyl groups
D5400_16255	COG2273	Hydrolase Family 16
D5400_16260	COG2244	polysaccharide biosynthetic process
D5400_16265	COG0463	Glycosyl transferase, family 2
D5400_16270	COG2327	Polysaccharide pyruvyl transferase
D5400_16275	COG1215	transferase activity, transferring glycosyl groups
D5400_16290	COG1596	polysaccharide export
D5400_16295	COG3307	-O-antigen
D5400_16330	COG0583	DNA-binding transcription factor activity
D5400_16340	COG1215	transferase activity, transferring glycosyl groups
D5400_16365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_16380	COG3706	GGDEF domain
D5400_16395	COG1120	ATPase activity
D5400_16400	COG4774	siderophore transport
D5400_16405	COG0679	Auxin Efflux Carrier
D5400_16410	COG1238	metal cluster binding
D5400_16415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5400_16435	COG0625	glutathione transferase activity
D5400_16440	COG0628	permease
D5400_16445	COG0840	transmembrane signaling receptor activity
D5400_16450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5400_16475	COG1573	uracil-dna glycosylase
D5400_16485	COG3920	Histidine kinase
D5400_16505	COG0308	aminopeptidase N
D5400_16510	COG2202	Pas domain
D5400_16510	COG2205	protein histidine kinase activity
D5400_16520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5400_16525	COG2205	protein histidine kinase activity
D5400_16535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5400_16540	COG3088	subunit of a heme lyase
D5400_16545	COG1138	Cytochrome C-type biogenesis protein
D5400_16550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5400_16555	COG4235	cytochrome complex assembly
D5400_16565	COG0642	Histidine kinase
D5400_16570	COG0745	RESPONSE REGULATOR receiver
D5400_16610	COG2983	Belongs to the UPF0260 family
D5400_16615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5400_16645	COG2205	protein histidine kinase activity
D5400_16655	COG2166	iron-sulfur cluster assembly
D5400_16670	COG4957	zinc ion binding
D5400_16675	COG1320	monovalent cation:proton antiporter activity
D5400_16680	COG2212	antiporter activity
D5400_16695	COG1006	Multisubunit Na H antiporter MnhC subunit
D5400_16710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5400_16725	COG2010	Cytochrome c
D5400_16735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5400_16740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5400_16750	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_16755	COG0433	COG0433 Predicted ATPase
D5400_16785	COG3685	Protein conserved in bacteria
D5400_16810	COG0489	protein tyrosine kinase activity
D5400_16820	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5400_16825	COG3842	ATPase activity
D5400_16830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5400_16835	COG4191	Histidine kinase
D5400_16835	COG0784	Response regulator, receiver
D5400_17010	COG4695	Portal protein
D5400_17070	COG3750	Belongs to the UPF0335 family
D5400_17145	COG2030	dehydratase
D5400_17155	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_17170	COG1268	BioY protein
D5400_17200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5400_17200	COG0574	Belongs to the PEP-utilizing enzyme family
D5400_17210	COG1196	nuclear chromosome segregation
D5400_17225	COG1194	a g-specific adenine glycosylase
D5400_17235	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D5400_17240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5400_17255	COG0612	Peptidase, M16
D5400_17265	COG3300	MHYT domain
D5400_17265	COG5001	Diguanylate cyclase
D5400_17270	COG1678	Uncharacterized ACR, COG1678
D5400_17280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5400_17280	COG0678	peroxiredoxin activity
D5400_17285	COG0328	RNA-DNA hybrid ribonuclease activity
D5400_17290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5400_17295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5400_17300	COG3346	SURF1 family
D5400_17315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D5400_17320	COG0109	protoheme IX farnesyltransferase activity
D5400_17325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5400_17330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5400_17340	COG0312	modulator of DNA gyrase
D5400_17345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_17355	COG0259	pyridoxamine-phosphate oxidase activity
D5400_17365	COG0484	heat shock protein binding
D5400_17370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5400_17375	COG0406	alpha-ribazole phosphatase activity
D5400_17380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5400_17390	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5400_17395	COG1722	exodeoxyribonuclease VII activity
D5400_17400	COG3300	MHYT domain
D5400_17400	COG5001	Diguanylate cyclase
D5400_17405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5400_17420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5400_17425	COG1024	Enoyl-CoA hydratase
D5400_17430	COG1960	acyl-CoA dehydrogenase activity
D5400_17435	COG0009	L-threonylcarbamoyladenylate synthase
D5400_17455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5400_17460	COG0151	Belongs to the GarS family
D5400_17475	COG0751	glycine-tRNA ligase activity
D5400_17480	COG0752	glycyl-tRNA synthetase alpha subunit
D5400_17505	COG0142	geranyltranstransferase activity
D5400_17515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5400_17520	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5400_17535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5400_17540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5400_17545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5400_17550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5400_17555	COG0356	it plays a direct role in the translocation of protons across the membrane
D5400_17570	COG1160	GTP binding
D5400_17585	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D5400_17590	COG0477	Major facilitator Superfamily
D5400_17610	COG0861	Integral membrane protein TerC family
D5400_17615	COG2217	Heavy metal translocating P-type atpase
D5400_17635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5400_17645	COG4566	intracellular signal transduction
D5400_17650	COG4191	Histidine kinase
D5400_17655	COG0519	Catalyzes the synthesis of GMP from XMP
D5400_17655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5400_17695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5400_17700	COG0248	Ppx GppA phosphatase
D5400_17720	COG0210	DNA helicase
D5400_17730	COG3706	GGDEF domain
D5400_17740	COG0784	Response regulator, receiver
D5400_17740	COG4191	Histidine kinase
D5400_17780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_17800	COG0702	epimerase
D5400_17805	COG3631	Ketosteroid isomerase-related protein
D5400_17810	COG1309	transcriptional regulator
D5400_17820	COG0300	oxidoreductase activity
D5400_17835	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5400_17850	COG4221	oxidoreductase activity
D5400_17860	COG1309	transcriptional regulator
D5400_17865	COG1505	serine-type exopeptidase activity
D5400_17870	COG0745	RESPONSE REGULATOR receiver
D5400_17875	COG0642	Histidine kinase
D5400_17885	COG1073	alpha beta
D5400_17890	COG2186	Transcriptional regulator
D5400_17895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_17905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_17915	COG1850	ribulose-bisphosphate carboxylase activity
D5400_17935	COG0300	oxidoreductase activity
D5400_17995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D5400_18000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D5400_18005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D5400_18010	COG2205	protein histidine kinase activity
D5400_18015	COG0745	RESPONSE REGULATOR receiver
D5400_18020	COG2423	ornithine cyclodeaminase activity
D5400_18030	COG1522	sequence-specific DNA binding
D5400_18055	COG4608	Belongs to the ABC transporter superfamily
D5400_18060	COG0444	Belongs to the ABC transporter superfamily
D5400_18095	COG1819	glycosyl
D5400_18105	COG3604	Transcriptional regulator
D5400_18110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5400_18110	COG1116	anion transmembrane transporter activity
D5400_18115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5400_18120	COG1116	anion transmembrane transporter activity
D5400_18125	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D5400_18145	COG1024	Enoyl-CoA hydratase
D5400_18175	COG1609	Transcriptional regulator
D5400_18185	COG1879	ABC-type sugar transport system periplasmic component
D5400_18190	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_18195	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_18200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5400_18210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5400_18215	COG2072	flavoprotein involved in K transport
D5400_18225	COG2144	transferase activity, transferring acyl groups
D5400_18235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5400_18250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5400_18275	COG2207	Transcriptional regulator
D5400_18280	COG3034	peptidoglycan biosynthetic process
D5400_18295	COG1126	abc transporter atp-binding protein
D5400_18315	COG0708	Exodeoxyribonuclease III
D5400_18330	COG2197	response regulator
D5400_18345	COG0667	Aldo Keto reductase
D5400_18355	COG2376	Dihydroxyacetone kinase
D5400_18360	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_18365	COG1129	ABC transporter
D5400_18370	COG1879	ABC-type sugar transport system periplasmic component
D5400_18375	COG1070	Carbohydrate kinase
D5400_18380	COG1363	Peptidase, m42
D5400_18385	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_18390	COG0434	BtpA family
D5400_18395	COG1349	DNA-binding transcription factor activity
D5400_18400	COG2186	Transcriptional regulator
D5400_18405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5400_18420	COG0698	ribose 5-phosphate isomerase
D5400_18475	COG1278	Cold shock
D5400_18485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5400_18490	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D5400_18500	COG0410	ABC transporter
D5400_18540	COG1012	belongs to the aldehyde dehydrogenase family
D5400_18550	COG3485	protocatechuate 3,4-dioxygenase
D5400_18575	COG1137	ATPase activity
D5400_18585	COG1454	alcohol dehydrogenase
D5400_18605	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
D5400_18610	COG0183	Belongs to the thiolase family
D5400_18625	COG0154	amidase activity
D5400_18640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_18650	COG2864	formate dehydrogenase
D5400_18655	COG0437	4 iron, 4 sulfur cluster binding
D5400_18660	COG3383	formate dehydrogenase (NAD+) activity
D5400_18660	COG0243	molybdopterin cofactor binding
D5400_18710	COG2197	response regulator
D5400_18715	COG4585	Histidine kinase
D5400_18740	COG4181	ATPase activity
D5400_18755	COG0798	PFAM Bile acid sodium symporter
D5400_18760	COG1404	Belongs to the peptidase S8 family
D5400_18775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5400_18800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5400_18805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5400_18810	COG3485	protocatechuate 3,4-dioxygenase
D5400_18815	COG3485	protocatechuate 3,4-dioxygenase
D5400_18820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5400_18825	COG2267	carboxylic ester hydrolase activity
D5400_18830	COG0583	DNA-binding transcription factor activity
D5400_18835	COG2197	response regulator
D5400_18840	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_18850	COG3300	MHYT domain
D5400_18850	COG5001	Diguanylate cyclase
D5400_18860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_18865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5400_18865	COG1321	iron dependent repressor
D5400_18870	COG1121	(ABC) transporter
D5400_18875	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5400_18880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5400_18890	COG1663	tetraacyldisaccharide 4'-kinase activity
D5400_18895	COG1519	Transferase
D5400_18910	COG0483	inositol monophosphate 1-phosphatase activity
D5400_18915	COG0312	modulator of DNA gyrase
D5400_18930	COG0742	ribosomal rna small subunit methyltransferase
D5400_18935	COG1187	pseudouridine synthase activity
D5400_18940	COG0590	tRNA wobble adenosine to inosine editing
D5400_18950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5400_18955	COG0196	riboflavin kinase activity
D5400_18965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5400_18970	COG0459	protein refolding
D5400_18975	COG1733	regulation of RNA biosynthetic process
D5400_18990	COG3706	GGDEF domain
D5400_18995	COG0625	glutathione transferase activity
D5400_19000	COG0730	response to heat
D5400_19005	COG0114	fumarate hydratase activity
D5400_19015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5400_19020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5400_19025	COG0124	histidyl-tRNA synthetase
D5400_19045	COG2818	Glycosylase
D5400_19050	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_19055	COG1388	LysM domain
D5400_19055	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_19060	COG0482	sulfurtransferase activity
D5400_19105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5400_19115	COG0564	pseudouridine synthase activity
D5400_19120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5400_19130	COG3038	cytochrome b561
D5400_19145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5400_19160	COG0840	transmembrane signaling receptor activity
D5400_19170	COG1047	Peptidyl-prolyl cis-trans
D5400_19175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5400_19220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5400_19225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5400_19230	COG0037	tRNA processing
D5400_19240	COG2885	chlorophyll binding
D5400_19255	COG0848	biopolymer transport protein
D5400_19265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5400_19270	COG0824	Thioesterase
D5400_19295	COG2255	four-way junction helicase activity
D5400_19300	COG0632	four-way junction helicase activity
D5400_19305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D5400_19310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5400_19320	COG0217	transcriptional regulatory protein
D5400_19340	COG1253	flavin adenine dinucleotide binding
D5400_19345	COG1692	metallophosphoesterase
D5400_19385	COG3263	regulation of cellular component size
D5400_19390	COG0126	phosphoglycerate kinase activity
D5400_19395	COG3588	fructose-bisphosphate aldolase
D5400_19410	COG0457	Tetratricopeptide repeat
D5400_19415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5400_19420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5400_19440	COG0640	Transcriptional regulator
D5400_19445	COG0318	PFAM AMP-dependent synthetase and ligase
D5400_19470	COG0483	inositol monophosphate 1-phosphatase activity
D5400_19485	COG1132	(ABC) transporter
D5400_19490	COG0254	rRNA binding
D5400_19515	COG0469	pyruvate kinase activity
D5400_19530	COG3750	Belongs to the UPF0335 family
D5400_19535	COG2862	Uncharacterized protein family, UPF0114
D5400_19545	COG2204	response regulator
D5400_19560	COG3668	Plasmid stabilization system
D5400_19570	COG5310	Homospermidine synthase
D5400_19580	COG0737	Belongs to the 5'-nucleotidase family
D5400_19585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5400_19600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5400_19605	COG2951	lytic endotransglycosylase activity
D5400_19620	COG0070	glutamate synthase
D5400_19620	COG0069	glutamate synthase activity
D5400_19620	COG0067	glutamate synthase
D5400_19635	COG0071	Belongs to the small heat shock protein (HSP20) family
D5400_19640	COG2267	carboxylic ester hydrolase activity
D5400_19685	COG4214	carbohydrate transport
D5400_19690	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5400_19725	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5400_19725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5400_19735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5400_19740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5400_19750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D5400_19755	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D5400_19760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D5400_19775	COG5001	Diguanylate cyclase
D5400_19775	COG3300	MHYT domain
D5400_19785	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_19790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_19795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D5400_19800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5400_19805	COG1609	Transcriptional regulator
D5400_19825	COG0523	cobalamin synthesis protein
D5400_19855	COG0583	DNA-binding transcription factor activity
D5400_19885	COG3273	potassium ion transport
D5400_19885	COG0471	metal ion transport
D5400_19910	COG0800	Aldolase
D5400_19930	COG1879	ABC-type sugar transport system periplasmic component
D5400_19935	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5400_19940	COG1129	ABC transporter
D5400_19945	COG0673	inositol 2-dehydrogenase activity
D5400_19955	COG1609	Transcriptional regulator
D5400_19960	COG2115	Belongs to the xylose isomerase family
D5400_19965	COG1070	Carbohydrate kinase
D5400_19970	COG1609	Transcriptional regulator
D5400_19980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5400_19985	COG0765	amino acid transport
D5400_19990	COG0765	amino acid transport
D5400_19995	COG1126	abc transporter atp-binding protein
D5400_20000	COG1846	Transcriptional regulator
D5400_20015	COG4206	TonB-dependent receptor
D5400_20025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5400_20030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D5400_20075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D5400_20085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5400_20115	COG1959	2 iron, 2 sulfur cluster binding
D5400_20120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5400_20130	COG4208	sulfate ABC transporter
D5400_20135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D5400_20145	COG0471	metal ion transport
D5400_20145	COG3273	potassium ion transport
D5400_20155	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
D5400_20160	COG4423	Transcription factor
D5400_20195	COG1122	ATPase activity
D5400_20200	COG1268	BioY protein
D5400_20215	COG0028	Belongs to the TPP enzyme family
D5400_20220	COG0235	Class ii aldolase
D5400_20230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_20275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_20295	COG2963	transposase activity
D5400_20305	COG1414	Transcriptional regulator
D5400_20310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D5400_20320	COG0439	Biotin carboxylase
D5400_20330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5400_20340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_20345	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_20350	COG1335	isochorismatase
D5400_20355	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_20365	COG2267	carboxylic ester hydrolase activity
D5400_20370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5400_20375	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D5400_20395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5400_20405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5400_20420	COG4638	Rieske (2fe-2S)
D5400_20435	COG1414	Transcriptional regulator
D5400_20450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5400_20465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_20490	COG4227	nucleotidyltransferase activity
D5400_20515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5400_20555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5400_20560	COG0459	protein refolding
D5400_20610	COG0659	secondary active sulfate transmembrane transporter activity
D5400_20615	COG0589	response to stress
D5400_20625	COG2755	lipolytic protein G-D-S-L family
D5400_20625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5400_20655	COG1910	domain protein
D5400_20705	COG0739	heme binding
D5400_20710	COG1376	ErfK ybiS ycfS ynhG family protein
D5400_20715	COG0542	response to heat
D5400_20725	COG2890	protein-(glutamine-N5) methyltransferase activity
D5400_20730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5400_20735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5400_20740	COG0527	aspartate kinase activity
D5400_20745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5400_20755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5400_20765	COG1040	competence protein
D5400_20785	COG0494	nUDIX hydrolase
D5400_20795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5400_20800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5400_20805	COG0653	protein targeting
D5400_20820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5400_20840	COG2176	DNA-directed DNA polymerase activity
D5400_20855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5400_20865	COG1295	ribonuclease BN
D5400_20870	COG0300	oxidoreductase activity
D5400_20890	COG2086	electron transfer activity
D5400_20900	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_20905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5400_20910	COG0165	Argininosuccinate lyase
D5400_20920	COG0019	diaminopimelate decarboxylase activity
D5400_20925	COG3706	GGDEF domain
D5400_20940	COG4191	Histidine kinase
D5400_20940	COG0784	Response regulator, receiver
D5400_20955	COG2884	Cell division ATP-binding protein ftsE
D5400_20985	COG0287	Prephenate dehydrogenase
D5400_20990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5400_20995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5400_21000	COG2813	Specifically methylates the guanine in position
D5400_21000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5400_21015	COG2226	methyltransferase
D5400_21025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5400_21045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5400_21050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D5400_21080	COG4536	flavin adenine dinucleotide binding
D5400_21085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5400_21090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5400_21100	COG4974	Belongs to the 'phage' integrase family
D5400_21105	COG0825	malonyl-CoA metabolic process
D5400_21125	COG1024	Enoyl-CoA hydratase
D5400_21125	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5400_21135	COG1028	Short-chain dehydrogenase reductase Sdr
D5400_21140	COG1902	pentaerythritol trinitrate reductase activity
D5400_21145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5400_21155	COG0450	alkyl hydroperoxide reductase
D5400_21165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5400_21175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5400_21180	COG2226	methyltransferase
D5400_21185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5400_21190	COG1024	Enoyl-CoA hydratase
D5400_21195	COG0268	Binds directly to 16S ribosomal RNA