locus-tag	class	description
WYH_00003	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WYH_00004	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WYH_00005	COG0271	Belongs to the BolA IbaG family
WYH_00007	COG0066	3-isopropylmalate dehydratase activity
WYH_00010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WYH_00013	COG2166	iron-sulfur cluster assembly
WYH_00022	COG1842	Phage shock protein A
WYH_00024	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WYH_00025	COG0779	Required for maturation of 30S ribosomal subunits
WYH_00027	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WYH_00028	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WYH_00030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WYH_00031	COG1435	thymidine kinase activity
WYH_00033	COG1994	Peptidase M50
WYH_00034	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WYH_00035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WYH_00036	COG1185	polyribonucleotide nucleotidyltransferase activity
WYH_00039	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_00041	COG2814	Major facilitator Superfamily
WYH_00042	COG0798	PFAM Bile acid sodium symporter
WYH_00045	COG2885	chlorophyll binding
WYH_00047	COG0842	Transport permease protein
WYH_00051	COG2936	dipeptidyl-peptidase activity
WYH_00053	COG4638	Rieske (2fe-2S)
WYH_00055	COG3384	dioxygenase
WYH_00058	COG2175	clavaminate synthase activity
WYH_00063	COG1335	isochorismatase
WYH_00064	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WYH_00066	COG0300	oxidoreductase activity
WYH_00067	COG1335	isochorismatase
WYH_00071	COG0583	DNA-binding transcription factor activity
WYH_00074	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WYH_00075	COG0049	tRNA binding
WYH_00076	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WYH_00077	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WYH_00078	COG0051	transcription antitermination factor activity, RNA binding
WYH_00079	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WYH_00080	COG0088	Forms part of the polypeptide exit tunnel
WYH_00081	COG0089	rRNA binding
WYH_00082	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WYH_00083	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WYH_00084	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WYH_00085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WYH_00086	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WYH_00087	COG0255	Belongs to the universal ribosomal protein uL29 family
WYH_00088	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WYH_00089	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WYH_00090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WYH_00091	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WYH_00092	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WYH_00093	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WYH_00094	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WYH_00095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WYH_00096	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WYH_00097	COG1841	ribosomal large subunit assembly
WYH_00098	COG0200	Binds to the 23S rRNA
WYH_00099	COG0201	protein transport
WYH_00100	COG0563	adenylate kinase activity
WYH_00102	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WYH_00103	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WYH_00104	COG0202	RNA polymerase activity
WYH_00105	COG0203	ribosomal protein L17
WYH_00106	COG1505	serine-type exopeptidase activity
WYH_00109	COG2860	membrane
WYH_00112	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_00113	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_00114	COG0567	Dehydrogenase, E1 component
WYH_00115	COG2827	Endonuclease containing a URI domain
WYH_00116	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WYH_00117	COG0039	L-malate dehydrogenase activity
WYH_00118	COG5001	Diguanylate cyclase
WYH_00122	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WYH_00123	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WYH_00130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WYH_00131	COG0137	argininosuccinate synthase activity
WYH_00132	COG0534	Mate efflux family protein
WYH_00133	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_00134	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_00135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WYH_00136	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
WYH_00142	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WYH_00143	COG1733	regulation of RNA biosynthetic process
WYH_00144	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WYH_00148	COG2268	Band 7 protein
WYH_00152	COG0741	lytic transglycosylase activity
WYH_00153	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WYH_00154	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WYH_00159	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WYH_00160	COG4106	trans-aconitate 2-methyltransferase activity
WYH_00161	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WYH_00164	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WYH_00165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WYH_00165	COG3153	acetyltransferase
WYH_00166	COG0538	isocitrate dehydrogenase activity
WYH_00169	COG4771	TonB-dependent receptor
WYH_00171	COG2244	polysaccharide biosynthetic process
WYH_00172	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WYH_00184	COG0742	ribosomal rna small subunit methyltransferase
WYH_00185	COG1187	pseudouridine synthase activity
WYH_00187	COG0285	dihydrofolate synthase activity
WYH_00188	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WYH_00189	COG0159	tryptophan synthase activity
WYH_00190	COG0133	tryptophan synthase activity
WYH_00191	COG0135	phosphoribosylanthranilate isomerase activity
WYH_00192	COG0284	orotidine-5'-phosphate decarboxylase activity
WYH_00194	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WYH_00198	COG2003	Belongs to the UPF0758 family
WYH_00203	COG0356	it plays a direct role in the translocation of protons across the membrane
WYH_00204	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WYH_00205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WYH_00206	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WYH_00207	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_00209	COG0539	negative regulation of cytoplasmic translation
WYH_00210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WYH_00212	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WYH_00215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WYH_00216	COG0228	four-way junction DNA binding
WYH_00217	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WYH_00222	COG0336	Belongs to the RNA methyltransferase TrmD family
WYH_00223	COG0335	large ribosomal subunit rRNA binding
WYH_00226	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WYH_00230	COG0189	ligase activity
WYH_00230	COG4067	protein conserved in archaea
WYH_00231	COG0189	ligase activity
WYH_00232	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WYH_00233	COG0359	binds to the 23S rRNA
WYH_00234	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WYH_00235	COG0360	Binds together with S18 to 16S ribosomal RNA
WYH_00236	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WYH_00240	COG0592	DNA-directed DNA polymerase activity
WYH_00241	COG0493	'glutamate synthase
WYH_00242	COG5001	Diguanylate cyclase
WYH_00242	COG3300	MHYT domain
WYH_00243	COG5001	Diguanylate cyclase
WYH_00243	COG3300	MHYT domain
WYH_00244	COG0481	GTPase activity
WYH_00251	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WYH_00255	COG0497	DNA recombination
WYH_00258	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WYH_00261	COG2264	protein methyltransferase activity
WYH_00263	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_00265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WYH_00267	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WYH_00268	COG1959	2 iron, 2 sulfur cluster binding
WYH_00275	COG2321	neutral zinc metallopeptidase
WYH_00276	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_00279	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WYH_00281	COG1051	belongs to the nudix hydrolase family
WYH_00282	COG0674	pyruvate-flavodoxin oxidoreductase activity
WYH_00282	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WYH_00283	COG1013	pyruvate-flavodoxin oxidoreductase activity
WYH_00285	COG0415	Belongs to the DNA photolyase family
WYH_00286	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_00288	COG4221	oxidoreductase activity
WYH_00289	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WYH_00292	COG1596	polysaccharide export
WYH_00296	COG2801	Transposase and inactivated derivatives
WYH_00302	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WYH_00310	COG2801	Transposase and inactivated derivatives
WYH_00310	COG3415	Transposase
WYH_00316	COG0346	lactoylglutathione lyase activity
WYH_00317	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_00318	COG4771	TonB-dependent receptor
WYH_00323	COG2814	Major facilitator Superfamily
WYH_00328	COG2814	Major facilitator Superfamily
WYH_00330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WYH_00333	COG4771	TonB-dependent receptor
WYH_00340	COG1609	Transcriptional regulator
WYH_00346	COG1940	carbohydrate kinase activity
WYH_00353	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WYH_00357	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WYH_00359	COG0126	phosphoglycerate kinase activity
WYH_00360	COG3588	fructose-bisphosphate aldolase
WYH_00362	COG0352	thiamine-phosphate diphosphorylase activity
WYH_00364	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WYH_00365	COG0483	inositol monophosphate 1-phosphatase activity
WYH_00367	COG3273	potassium ion transport
WYH_00367	COG0471	metal ion transport
WYH_00369	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WYH_00370	COG4191	Histidine kinase
WYH_00371	COG2204	response regulator
WYH_00374	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WYH_00375	COG0733	neurotransmitter:sodium symporter activity
WYH_00379	COG0745	RESPONSE REGULATOR receiver
WYH_00380	COG0704	Plays a role in the regulation of phosphate uptake
WYH_00381	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WYH_00383	COG0573	inorganic phosphate transmembrane transporter activity
WYH_00385	COG3746	phosphate-selective porin O and P
WYH_00386	COG5002	protein histidine kinase activity
WYH_00389	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WYH_00392	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WYH_00393	COG2353	YceI-like domain
WYH_00394	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WYH_00396	COG0028	Belongs to the TPP enzyme family
WYH_00397	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WYH_00398	COG3830	Belongs to the UPF0237 family
WYH_00398	COG0560	Phosphoserine phosphatase
WYH_00399	COG2311	Membrane
WYH_00400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WYH_00401	COG1722	exodeoxyribonuclease VII activity
WYH_00402	COG0142	geranyltranstransferase activity
WYH_00403	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WYH_00404	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WYH_00405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WYH_00406	COG0662	Cupin 2, conserved barrel domain protein
WYH_00407	COG1131	(ABC) transporter
WYH_00408	COG0842	Transport permease protein
WYH_00410	COG0343	queuine tRNA-ribosyltransferase activity
WYH_00411	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WYH_00414	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WYH_00415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WYH_00416	COG0698	ribose 5-phosphate isomerase
WYH_00419	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WYH_00421	COG1610	YqeY-like protein
WYH_00422	COG0505	Belongs to the CarA family
WYH_00425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WYH_00431	COG0148	phosphopyruvate hydratase activity
WYH_00432	COG0667	Aldo Keto reductase
WYH_00433	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WYH_00434	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WYH_00434	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WYH_00435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WYH_00438	COG1304	FMN binding
WYH_00442	COG4206	TonB-dependent receptor
WYH_00443	COG0477	Major facilitator Superfamily
WYH_00444	COG1802	Transcriptional regulator
WYH_00445	COG4206	TonB-dependent receptor
WYH_00445	COG4206	TonB-dependent receptor
WYH_00456	COG0028	Belongs to the TPP enzyme family
WYH_00465	COG4771	TonB-dependent receptor
WYH_00470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WYH_00471	COG0022	dehydrogenase e1 component
WYH_00471	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_00477	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
WYH_00479	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WYH_00482	COG0012	GTP binding
WYH_00484	COG0193	aminoacyl-tRNA hydrolase activity
WYH_00485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WYH_00488	COG0752	glycyl-tRNA synthetase alpha subunit
WYH_00489	COG0751	glycine-tRNA ligase activity
WYH_00490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_00490	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_00492	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WYH_00493	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WYH_00494	COG1960	acyl-CoA dehydrogenase activity
WYH_00500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WYH_00502	COG3876	Protein conserved in bacteria
WYH_00503	COG0006	proline dipeptidase activity
WYH_00507	COG0187	DNA topoisomerase II activity
WYH_00509	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WYH_00510	COG0792	nuclease activity
WYH_00511	COG0189	ligase activity
WYH_00512	COG0586	Pfam SNARE associated Golgi protein
WYH_00513	COG4974	Belongs to the 'phage' integrase family
WYH_00514	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WYH_00515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WYH_00516	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WYH_00517	COG1420	regulation of RNA biosynthetic process
WYH_00518	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WYH_00522	COG0443	Heat shock 70 kDa protein
WYH_00523	COG0484	heat shock protein binding
WYH_00528	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WYH_00530	COG0442	prolyl-tRNA aminoacylation
WYH_00531	COG0557	exoribonuclease II activity
WYH_00533	COG0508	dehydrogenase complex catalyzes the overall conversion of
WYH_00535	COG1607	acyl-coa hydrolase
WYH_00536	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_00538	COG0427	acetyl-CoA hydrolase
WYH_00541	COG2951	lytic endotransglycosylase activity
WYH_00543	COG1686	Belongs to the peptidase S11 family
WYH_00544	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WYH_00547	COG0084	hydrolase, TatD family'
WYH_00548	COG1234	tRNA 3'-trailer cleavage
WYH_00550	COG3956	TIGRFAM MazG family protein
WYH_00551	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WYH_00552	COG1923	regulation of RNA biosynthetic process
WYH_00553	COG2204	response regulator
WYH_00554	COG5000	phosphorelay sensor kinase activity
WYH_00555	COG2204	response regulator
WYH_00556	COG3852	Histidine kinase
WYH_00558	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WYH_00558	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WYH_00559	COG1546	Belongs to the CinA family
WYH_00560	COG2867	negative regulation of translational initiation
WYH_00561	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WYH_00562	COG0288	reversible hydration of carbon dioxide
WYH_00567	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WYH_00572	COG0772	Belongs to the SEDS family
WYH_00576	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WYH_00577	COG4637	Psort location Cytoplasmic, score
WYH_00586	COG0358	DNA primase activity
WYH_00588	COG4974	Belongs to the 'phage' integrase family
WYH_00592	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WYH_00593	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WYH_00594	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_00595	COG0504	CTP synthase activity
WYH_00597	COG0149	triose-phosphate isomerase activity
WYH_00599	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WYH_00601	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WYH_00602	COG0134	indole-3-glycerol-phosphate synthase activity
WYH_00604	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WYH_00605	COG0315	cyclic pyranopterin monophosphate synthase activity
WYH_00606	COG0303	'Molybdopterin
WYH_00607	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WYH_00608	COG2333	competence protein COMEC
WYH_00608	COG0658	competence protein
WYH_00609	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_00610	COG0372	Belongs to the citrate synthase family
WYH_00612	COG2205	protein histidine kinase activity
WYH_00619	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WYH_00620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WYH_00620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WYH_00621	COG1007	ATP synthesis coupled electron transport
WYH_00624	COG0713	ATP synthesis coupled electron transport
WYH_00626	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_00627	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WYH_00628	COG1034	ATP synthesis coupled electron transport
WYH_00630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WYH_00631	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WYH_00632	COG0649	NAD binding
WYH_00633	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_00634	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_00635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WYH_00636	COG0183	Belongs to the thiolase family
WYH_00640	COG2226	methyltransferase
WYH_00642	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WYH_00643	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WYH_00644	COG0860	N-Acetylmuramoyl-L-alanine amidase
WYH_00645	COG1530	ribonuclease E activity
WYH_00647	COG2226	methyltransferase
WYH_00649	COG1181	Belongs to the D-alanine--D-alanine ligase family
WYH_00652	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WYH_00658	COG3409	Peptidoglycan-binding domain 1 protein
WYH_00658	COG3267	Type II secretory pathway component ExeA
WYH_00669	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WYH_00670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WYH_00670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WYH_00672	COG0129	dihydroxy-acid dehydratase activity
WYH_00674	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WYH_00678	COG0521	Mo-molybdopterin cofactor biosynthetic process
WYH_00679	COG0521	Mo-molybdopterin cofactor biosynthetic process
WYH_00683	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WYH_00683	COG2885	chlorophyll binding
WYH_00684	COG0587	DNA-directed DNA polymerase activity
WYH_00687	COG1136	(ABC) transporter
WYH_00689	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WYH_00691	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WYH_00693	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WYH_00697	COG0477	Major facilitator Superfamily
WYH_00697	COG2814	Major facilitator Superfamily
WYH_00699	COG0653	protein targeting
WYH_00701	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WYH_00702	COG0483	inositol monophosphate 1-phosphatase activity
WYH_00704	COG1074	ATP-dependent DNA helicase activity
WYH_00706	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WYH_00707	COG3178	'Phosphotransferase
WYH_00708	COG0802	atpase or kinase
WYH_00709	COG2205	protein histidine kinase activity
WYH_00710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WYH_00711	COG0678	peroxiredoxin activity
WYH_00711	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WYH_00713	COG0302	gtp cyclohydrolase
WYH_00714	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_00717	COG0494	nUDIX hydrolase
WYH_00720	COG4783	chaperone-mediated protein folding
WYH_00721	COG0825	malonyl-CoA metabolic process
WYH_00722	COG4974	Belongs to the 'phage' integrase family
WYH_00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WYH_00726	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WYH_00730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WYH_00732	COG0513	Belongs to the DEAD box helicase family
WYH_00735	COG0166	Belongs to the GPI family
WYH_00736	COG0681	Belongs to the peptidase S26 family
WYH_00737	COG0571	ribonuclease III activity
WYH_00738	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WYH_00739	COG2814	Major facilitator Superfamily
WYH_00741	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WYH_00741	COG1754	DNA topoisomerase type I activity
WYH_00742	COG0758	DNA mediated transformation
WYH_00743	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WYH_00744	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WYH_00745	COG0156	8-amino-7-oxononanoate synthase activity
WYH_00754	COG1748	Saccharopine dehydrogenase
WYH_00756	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WYH_00757	COG3387	PFAM Glycoside hydrolase 15-related
WYH_00758	COG1877	trehalose-phosphatase activity
WYH_00762	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WYH_00771	COG0842	Transport permease protein
WYH_00772	COG1129	ABC transporter
WYH_00772	COG0842	Transport permease protein
WYH_00773	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_00777	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_00779	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WYH_00780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_00790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WYH_00796	COG0739	heme binding
WYH_00796	COG0741	lytic transglycosylase activity
WYH_00796	COG1196	nuclear chromosome segregation
WYH_00797	COG0582	viral genome integration into host DNA
WYH_00799	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WYH_00800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WYH_00801	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WYH_00802	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WYH_00803	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WYH_00804	COG0583	DNA-binding transcription factor activity
WYH_00805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WYH_00810	COG5001	Diguanylate cyclase
WYH_00810	COG3300	MHYT domain
WYH_00811	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WYH_00812	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_00813	COG0552	protein localization to endoplasmic reticulum
WYH_00814	COG2917	probably involved in intracellular septation
WYH_00816	COG3158	transport of potassium into the cell
WYH_00818	COG3088	subunit of a heme lyase
WYH_00819	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WYH_00820	COG1138	Cytochrome C-type biogenesis protein
WYH_00821	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WYH_00823	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WYH_00828	COG0254	rRNA binding
WYH_00829	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WYH_00832	COG0750	zinc metalloprotease
WYH_00833	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WYH_00835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WYH_00836	COG0233	cytoplasmic translational termination
WYH_00837	COG0528	UMP kinase activity
WYH_00838	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WYH_00839	COG0052	Belongs to the universal ribosomal protein uS2 family
WYH_00842	COG0688	phosphatidylethanolamine metabolic process
WYH_00846	COG0535	radical SAM domain protein
WYH_00853	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WYH_00856	COG0582	viral genome integration into host DNA
WYH_00858	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WYH_00863	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WYH_00866	COG1643	Atp-dependent helicase
WYH_00868	COG0142	geranyltranstransferase activity
WYH_00869	COG0287	Prephenate dehydrogenase
WYH_00869	COG1605	Chorismate mutase
WYH_00871	COG2205	protein histidine kinase activity
WYH_00872	COG0745	RESPONSE REGULATOR receiver
WYH_00877	COG0438	transferase activity, transferring glycosyl groups
WYH_00879	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WYH_00883	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WYH_00884	COG0511	ligase activity, forming carbon-carbon bonds
WYH_00885	COG0439	Biotin carboxylase
WYH_00887	COG1522	sequence-specific DNA binding
WYH_00888	COG2205	protein histidine kinase activity
WYH_00893	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WYH_00894	COG1301	dicarboxylic acid transport
WYH_00897	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WYH_00898	COG4948	Mandelate Racemase Muconate Lactonizing
WYH_00901	COG4771	TonB-dependent receptor
WYH_00903	COG1609	Transcriptional regulator
WYH_00909	COG2079	MmgE PrpD family protein
WYH_00917	COG1254	Belongs to the acylphosphatase family
WYH_00921	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WYH_00926	COG0402	S-adenosylhomocysteine deaminase activity
WYH_00928	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WYH_00928	COG1199	ATP-dependent helicase activity
WYH_00931	COG0776	regulation of translation
WYH_00932	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WYH_00933	COG0416	fatty acid biosynthetic process
WYH_00934	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_00938	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_00939	COG0215	cysteine-tRNA ligase activity
WYH_00941	COG1346	cytolysis
WYH_00944	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WYH_00950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WYH_00951	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WYH_00952	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WYH_00953	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WYH_00954	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WYH_00963	COG0357	Ribosomal RNA small subunit methyltransferase G
WYH_00965	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WYH_00968	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WYH_00969	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WYH_00970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WYH_00975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WYH_00977	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WYH_00978	COG2133	pyrroloquinoline quinone binding
WYH_00982	COG0617	tRNA 3'-terminal CCA addition
WYH_00984	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WYH_00985	COG0693	protein deglycase activity
WYH_00986	COG0633	Ferredoxin
WYH_00987	COG1104	cysteine desulfurase activity
WYH_00988	COG1104	cysteine desulfurase activity
WYH_00989	COG2945	thiolester hydrolase activity
WYH_00995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WYH_00996	COG0745	RESPONSE REGULATOR receiver
WYH_00997	COG0642	Histidine kinase
WYH_00999	COG1660	Displays ATPase and GTPase activities
WYH_01000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WYH_01000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WYH_01002	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WYH_01004	COG1322	Protein conserved in bacteria
WYH_01005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WYH_01006	COG1295	ribonuclease BN
WYH_01008	COG0242	peptide deformylase activity
WYH_01009	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WYH_01010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WYH_01012	COG0101	tRNA pseudouridine synthase activity
WYH_01013	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WYH_01015	COG1733	regulation of RNA biosynthetic process
WYH_01016	COG0625	glutathione transferase activity
WYH_01017	COG5507	3-demethylubiquinone-9 3-methyltransferase
WYH_01021	COG1741	Belongs to the pirin family
WYH_01024	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WYH_01025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WYH_01026	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WYH_01028	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WYH_01029	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WYH_01033	COG0322	excinuclease ABC activity
WYH_01034	COG2081	HI0933 family
WYH_01036	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WYH_01037	COG0424	maF-like protein
WYH_01041	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WYH_01043	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WYH_01047	COG2814	Major facilitator Superfamily
WYH_01049	COG1968	undecaprenyl-diphosphatase activity
WYH_01050	COG4771	TonB-dependent receptor
WYH_01052	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WYH_01053	COG0612	Peptidase, M16
WYH_01054	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WYH_01055	COG0047	phosphoribosylformylglycinamidine synthase activity
WYH_01056	COG5001	Diguanylate cyclase
WYH_01058	COG2212	antiporter activity
WYH_01060	COG0651	ATP synthesis coupled electron transport
WYH_01061	COG1006	Multisubunit Na H antiporter MnhC subunit
WYH_01062	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WYH_01062	COG2111	Na H antiporter
WYH_01064	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WYH_01066	COG2989	Protein conserved in bacteria
WYH_01069	COG1136	(ABC) transporter
WYH_01070	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_01079	COG4771	TonB-dependent receptor
WYH_01080	COG5001	Diguanylate cyclase
WYH_01082	COG3836	Belongs to the HpcH HpaI aldolase family
WYH_01083	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WYH_01084	COG1454	alcohol dehydrogenase
WYH_01086	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_01089	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01090	COG3246	L-lysine catabolic process to acetate
WYH_01107	COG2132	Multicopper oxidase
WYH_01108	COG1937	Protein conserved in bacteria
WYH_01109	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WYH_01110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WYH_01111	COG0546	phosphoglycolate phosphatase activity
WYH_01113	COG1045	serine acetyltransferase
WYH_01114	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WYH_01116	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WYH_01117	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WYH_01119	COG0105	UTP biosynthetic process
WYH_01122	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WYH_01124	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WYH_01125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WYH_01126	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WYH_01128	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WYH_01131	COG3724	N-succinylarginine dihydrolase activity
WYH_01134	COG1970	mechanosensitive ion channel activity
WYH_01140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WYH_01143	COG0572	uridine kinase
WYH_01145	COG4993	Dehydrogenase
WYH_01147	COG2010	Cytochrome c
WYH_01151	COG4993	Dehydrogenase
WYH_01157	COG4993	Dehydrogenase
WYH_01160	COG2967	ApaG domain
WYH_01161	COG3920	Histidine kinase
WYH_01167	COG0473	3-isopropylmalate dehydrogenase activity
WYH_01168	COG1381	Involved in DNA repair and RecF pathway recombination
WYH_01172	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WYH_01174	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WYH_01180	COG0435	Glutathione S-transferase
WYH_01181	COG0625	glutathione transferase activity
WYH_01186	COG2801	Transposase and inactivated derivatives
WYH_01186	COG3415	Transposase
WYH_01192	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01196	COG2814	Major facilitator Superfamily
WYH_01200	COG1477	protein flavinylation
WYH_01201	COG3128	pkhd-type hydroxylase
WYH_01202	COG4774	siderophore transport
WYH_01207	COG3119	arylsulfatase activity
WYH_01208	COG4771	TonB-dependent receptor
WYH_01210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WYH_01211	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WYH_01212	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WYH_01213	COG0612	Peptidase, M16
WYH_01214	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WYH_01215	COG0778	Nitroreductase
WYH_01217	COG0456	acetyltransferase
WYH_01221	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_01223	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WYH_01225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WYH_01226	COG1253	flavin adenine dinucleotide binding
WYH_01228	COG0583	DNA-binding transcription factor activity
WYH_01230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WYH_01231	COG2239	Acts as a magnesium transporter
WYH_01236	COG2816	NAD+ diphosphatase activity
WYH_01239	COG1194	a g-specific adenine glycosylase
WYH_01243	COG1196	nuclear chromosome segregation
WYH_01244	COG0789	Transcriptional regulator
WYH_01249	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WYH_01255	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WYH_01256	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01260	COG0418	dihydroorotase activity
WYH_01262	COG0354	folic acid binding
WYH_01265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WYH_01266	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WYH_01268	COG0314	molybdopterin synthase activity
WYH_01270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WYH_01279	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WYH_01281	COG0109	protoheme IX farnesyltransferase activity
WYH_01282	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WYH_01284	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WYH_01285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WYH_01286	COG0736	holo-[acyl-carrier-protein] synthase activity
WYH_01287	COG0681	Belongs to the peptidase S26 family
WYH_01288	COG0628	permease
WYH_01290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WYH_01291	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WYH_01291	COG1648	precorrin-2 dehydrogenase activity
WYH_01292	COG0019	diaminopimelate decarboxylase activity
WYH_01294	COG0165	Argininosuccinate lyase
WYH_01295	COG3118	belongs to the thioredoxin family
WYH_01306	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WYH_01307	COG2755	lipolytic protein G-D-S-L family
WYH_01308	COG4181	ATPase activity
WYH_01310	COG4771	TonB-dependent receptor
WYH_01311	COG0297	glycogen (starch) synthase activity
WYH_01313	COG1695	Transcriptional regulator
WYH_01314	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WYH_01319	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WYH_01321	COG2897	thiosulfate sulfurtransferase activity
WYH_01322	COG0626	cystathionine gamma-synthase activity
WYH_01323	COG0668	transmembrane transport
WYH_01324	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WYH_01324	COG1648	precorrin-2 dehydrogenase activity
WYH_01326	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WYH_01328	COG0175	sulfate reduction
WYH_01330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WYH_01331	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WYH_01334	COG0670	Belongs to the BI1 family
WYH_01335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WYH_01338	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WYH_01339	COG0849	cell division
WYH_01340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WYH_01341	COG1181	Belongs to the D-alanine--D-alanine ligase family
WYH_01342	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WYH_01343	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WYH_01344	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WYH_01346	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WYH_01347	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WYH_01348	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WYH_01349	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WYH_01352	COG0275	rRNA processing
WYH_01353	COG2001	Belongs to the MraZ family
WYH_01356	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WYH_01360	COG2154	pterin-4-alpha-carbinolamine dehydratase
WYH_01361	COG4133	protoheme IX ABC transporter activity
WYH_01362	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WYH_01364	COG0457	Tetratricopeptide repeat
WYH_01367	COG0024	Methionine aminopeptidase
WYH_01369	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WYH_01371	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WYH_01373	COG0174	glutamine synthetase
WYH_01377	COG0729	surface antigen
WYH_01378	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WYH_01379	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WYH_01380	COG2084	Dehydrogenase
WYH_01381	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WYH_01383	COG0805	protein transport
WYH_01384	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WYH_01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WYH_01386	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WYH_01387	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WYH_01388	COG1472	Belongs to the glycosyl hydrolase 3 family
WYH_01391	COG0018	arginyl-trna synthetase
WYH_01393	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WYH_01394	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WYH_01395	COG0328	RNA-DNA hybrid ribonuclease activity
WYH_01396	COG0670	Belongs to the BI1 family
WYH_01397	COG0583	DNA-binding transcription factor activity
WYH_01401	COG3422	double-strand break repair
WYH_01406	COG4964	Belongs to the GSP D family
WYH_01412	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WYH_01415	COG0457	Tetratricopeptide repeat
WYH_01418	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WYH_01420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WYH_01422	COG0154	amidase activity
WYH_01423	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WYH_01426	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WYH_01427	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WYH_01429	COG0546	phosphoglycolate phosphatase activity
WYH_01435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WYH_01436	COG0525	valine-tRNA ligase activity
WYH_01438	COG0534	Mate efflux family protein
WYH_01439	COG0784	Response regulator, receiver
WYH_01442	COG0730	response to heat
WYH_01445	COG1215	transferase activity, transferring glycosyl groups
WYH_01449	COG0544	peptidyl-prolyl cis-trans isomerase activity
WYH_01451	COG0154	amidase activity
WYH_01452	COG2814	Major facilitator Superfamily
WYH_01454	COG4774	siderophore transport
WYH_01455	COG1309	transcriptional regulator
WYH_01456	COG1846	Transcriptional regulator
WYH_01458	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WYH_01459	COG1902	pentaerythritol trinitrate reductase activity
WYH_01460	COG0488	(ABC) transporter
WYH_01463	COG0740	serine-type endopeptidase activity
WYH_01464	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WYH_01466	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WYH_01468	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WYH_01469	COG0564	pseudouridine synthase activity
WYH_01472	COG3023	N-Acetylmuramoyl-L-alanine amidase
WYH_01477	COG1160	GTP binding
WYH_01481	COG2311	Membrane
WYH_01483	COG1192	Involved in chromosome partitioning
WYH_01486	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WYH_01487	COG0540	Belongs to the ATCase OTCase family
WYH_01488	COG0616	signal peptide processing
WYH_01494	COG1058	Belongs to the CinA family
WYH_01494	COG1546	Belongs to the CinA family
WYH_01495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WYH_01496	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WYH_01497	COG2080	2 iron, 2 sulfur cluster binding
WYH_01498	COG3665	Urea carboxylase-associated protein
WYH_01505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WYH_01506	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WYH_01510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WYH_01511	COG4771	TonB-dependent receptor
WYH_01514	COG0432	Pfam Uncharacterised protein family UPF0047
WYH_01516	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WYH_01517	COG0129	dihydroxy-acid dehydratase activity
WYH_01518	COG0837	glucose binding
WYH_01519	COG0800	Aldolase
WYH_01522	COG0037	tRNA processing
WYH_01532	COG4325	translation initiation factor activity
WYH_01536	COG0321	lipoyl(octanoyl) transferase activity
WYH_01540	COG2080	2 iron, 2 sulfur cluster binding
WYH_01541	COG0235	Class ii aldolase
WYH_01543	COG2271	Major facilitator Superfamily
WYH_01544	COG2207	Transcriptional regulator
WYH_01548	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_01550	COG1063	alcohol dehydrogenase
WYH_01552	COG0784	Response regulator, receiver
WYH_01558	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WYH_01560	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_01561	COG0436	Aminotransferase
WYH_01562	COG2271	Major facilitator Superfamily
WYH_01563	COG0129	dihydroxy-acid dehydratase activity
WYH_01568	COG0445	tRNA wobble uridine modification
WYH_01577	COG0577	efflux transmembrane transporter activity
WYH_01577	COG1136	(ABC) transporter
WYH_01578	COG0577	efflux transmembrane transporter activity
WYH_01578	COG1136	(ABC) transporter
WYH_01580	COG1136	(ABC) transporter
WYH_01580	COG0577	efflux transmembrane transporter activity
WYH_01580	COG1136	(ABC) transporter
WYH_01580	COG0577	efflux transmembrane transporter activity
WYH_01581	COG0577	efflux transmembrane transporter activity
WYH_01581	COG1136	(ABC) transporter
WYH_01585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WYH_01586	COG4149	molybdate abc transporter
WYH_01587	COG0725	ABC transporter, periplasmic molybdate-binding protein
WYH_01588	COG3920	Histidine kinase
WYH_01593	COG2175	clavaminate synthase activity
WYH_01594	COG0402	S-adenosylhomocysteine deaminase activity
WYH_01596	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WYH_01598	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WYH_01600	COG0351	phosphomethylpyrimidine kinase
WYH_01600	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WYH_01600	COG0352	thiamine-phosphate diphosphorylase activity
WYH_01604	COG0513	Belongs to the DEAD box helicase family
WYH_01607	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WYH_01609	COG0077	Prephenate dehydratase
WYH_01612	COG0714	Associated with various cellular activities
WYH_01616	COG0454	-acetyltransferase
WYH_01620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WYH_01624	COG2989	Protein conserved in bacteria
WYH_01627	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WYH_01629	COG2255	four-way junction helicase activity
WYH_01630	COG0632	four-way junction helicase activity
WYH_01631	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WYH_01632	COG0450	alkyl hydroperoxide reductase
WYH_01637	COG4395	Tim44
WYH_01638	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WYH_01639	COG0728	peptidoglycan biosynthetic process
WYH_01640	COG0180	Tryptophanyl-tRNA synthetase
WYH_01642	COG0756	dUTP diphosphatase activity
WYH_01643	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WYH_01645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WYH_01646	COG2226	methyltransferase
WYH_01648	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WYH_01649	COG0268	Binds directly to 16S ribosomal RNA
WYH_01650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WYH_01652	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WYH_01653	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WYH_01654	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WYH_01657	COG1301	dicarboxylic acid transport
WYH_01658	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WYH_01659	COG0625	glutathione transferase activity
WYH_01663	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WYH_01664	COG0706	membrane insertase activity
WYH_01665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WYH_01666	COG0594	ribonuclease P activity
WYH_01667	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WYH_01669	COG0606	chelatase, subunit chli
WYH_01670	COG4993	Dehydrogenase
WYH_01672	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WYH_01677	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WYH_01682	COG0753	catalase activity
WYH_01688	COG1764	response to oxidative stress
WYH_01689	COG1846	Transcriptional regulator
WYH_01695	COG2205	protein histidine kinase activity
WYH_01697	COG0668	transmembrane transport
WYH_01698	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_01703	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_01704	COG1252	NADH dehydrogenase
WYH_01710	COG0606	chelatase, subunit chli
WYH_01713	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WYH_01716	COG2866	Carboxypeptidase
WYH_01719	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WYH_01721	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WYH_01722	COG0295	cytidine deaminase activity
WYH_01724	COG5328	Belongs to the UPF0262 family
WYH_01725	COG0305	Participates in initiation and elongation during chromosome replication
WYH_01728	COG1758	RNA polymerase activity
WYH_01738	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WYH_01739	COG0730	response to heat
WYH_01741	COG1482	cell wall glycoprotein biosynthetic process
WYH_01750	COG1132	(ABC) transporter
WYH_01752	COG1596	polysaccharide export
WYH_01753	COG0463	Glycosyl transferase, family 2
WYH_01754	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WYH_01761	COG1215	transferase activity, transferring glycosyl groups
WYH_01762	COG0438	transferase activity, transferring glycosyl groups
WYH_01763	COG1215	transferase activity, transferring glycosyl groups
WYH_01775	COG2273	Hydrolase Family 16
WYH_01777	COG0730	response to heat
WYH_01778	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_01778	COG3453	Protein conserved in bacteria
WYH_01780	COG0450	alkyl hydroperoxide reductase
WYH_01781	COG0640	Transcriptional regulator
WYH_01782	COG3118	belongs to the thioredoxin family
WYH_01785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WYH_01786	COG0446	pyridine nucleotide-disulphide oxidoreductase
WYH_01789	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WYH_01790	COG4988	ABC transporter
WYH_01791	COG1271	oxidase subunit
WYH_01792	COG1294	oxidase, subunit
WYH_01794	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WYH_01795	COG4771	TonB-dependent receptor
WYH_01798	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WYH_01805	COG0438	transferase activity, transferring glycosyl groups
WYH_01806	COG0438	transferase activity, transferring glycosyl groups
WYH_01808	COG0489	protein tyrosine kinase activity
WYH_01809	COG2197	response regulator
WYH_01810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WYH_01811	COG0022	dehydrogenase e1 component
WYH_01818	COG1086	Polysaccharide biosynthesis protein
WYH_01819	COG0438	transferase activity, transferring glycosyl groups
WYH_01821	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WYH_01822	COG2197	response regulator
WYH_01823	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WYH_01829	COG1309	transcriptional regulator
WYH_01831	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_01832	COG1538	Outer membrane efflux protein
WYH_01833	COG4206	TonB-dependent receptor
WYH_01841	COG0745	RESPONSE REGULATOR receiver
WYH_01844	COG0300	oxidoreductase activity
WYH_01846	COG4771	TonB-dependent receptor
WYH_01848	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_01849	COG0179	Fumarylacetoacetate (FAA) hydrolase
WYH_01855	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01857	COG3971	2-oxopent-4-enoate hydratase activity
WYH_01861	COG0583	DNA-binding transcription factor activity
WYH_01865	COG4771	TonB-dependent receptor
WYH_01867	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_01869	COG4638	Rieske (2fe-2S)
WYH_01870	COG0583	DNA-binding transcription factor activity
WYH_01871	COG0412	Dienelactone hydrolase
WYH_01879	COG3485	protocatechuate 3,4-dioxygenase
WYH_01882	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WYH_01884	COG1414	Transcriptional regulator
WYH_01888	COG2197	response regulator
WYH_01894	COG2801	Transposase and inactivated derivatives
WYH_01894	COG3415	Transposase
WYH_01895	COG0582	viral genome integration into host DNA
WYH_01898	COG2133	pyrroloquinoline quinone binding
WYH_01902	COG3618	amidohydrolase
WYH_01904	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WYH_01906	COG2159	amidohydrolase
WYH_01915	COG0456	acetyltransferase
WYH_01920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WYH_01922	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01924	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_01927	COG2175	clavaminate synthase activity
WYH_01929	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_01932	COG2119	membrane
WYH_01934	COG1012	belongs to the aldehyde dehydrogenase family
WYH_01937	COG0527	aspartate kinase activity
WYH_01938	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WYH_01939	COG3781	membrane
WYH_01940	COG2375	cellular response to nickel ion
WYH_01941	COG1393	Belongs to the ArsC family
WYH_01943	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WYH_01944	COG0217	transcriptional regulatory protein
WYH_01946	COG0393	Putative heavy-metal-binding
WYH_01947	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_01948	COG3750	Belongs to the UPF0335 family
WYH_01950	COG0469	pyruvate kinase activity
WYH_01951	COG4974	Belongs to the 'phage' integrase family
WYH_01968	COG3451	type IV secretory pathway VirB4
WYH_01971	COG4962	Type ii secretion system protein e
WYH_01973	COG3668	Plasmid stabilization system
WYH_01989	COG0741	lytic transglycosylase activity
WYH_01992	COG0741	lytic transglycosylase activity
WYH_01995	COG0741	lytic transglycosylase activity
WYH_02006	COG5489	Protein of unknown function (DUF736)
WYH_02009	COG1742	UPF0060 membrane protein
WYH_02013	COG3118	belongs to the thioredoxin family
WYH_02015	COG2095	MarC family integral membrane protein
WYH_02019	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WYH_02020	COG2326	polyphosphate kinase activity
WYH_02025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WYH_02025	COG1372	Participates in initiation and elongation during chromosome replication
WYH_02030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WYH_02030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WYH_02034	COG1131	(ABC) transporter
WYH_02042	COG0583	DNA-binding transcription factor activity
WYH_02044	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WYH_02044	COG0519	Catalyzes the synthesis of GMP from XMP
WYH_02047	COG0187	DNA topoisomerase II activity
WYH_02050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WYH_02052	COG1960	acyl-CoA dehydrogenase activity
WYH_02054	COG1125	glycine betaine transport
WYH_02057	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WYH_02058	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WYH_02061	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WYH_02063	COG1674	ftsk spoiiie
WYH_02065	COG4771	TonB-dependent receptor
WYH_02068	COG0488	(ABC) transporter
WYH_02070	COG0686	Belongs to the AlaDH PNT family
WYH_02071	COG3706	GGDEF domain
WYH_02077	COG0745	RESPONSE REGULATOR receiver
WYH_02078	COG2205	protein histidine kinase activity
WYH_02080	COG0433	COG0433 Predicted ATPase
WYH_02081	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WYH_02081	COG0512	Glutamine amidotransferase of anthranilate synthase
WYH_02083	COG0564	pseudouridine synthase activity
WYH_02085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WYH_02093	COG0514	ATP-dependent DNA helicase (RecQ)
WYH_02096	COG3186	Phenylalanine-4-hydroxylase
WYH_02098	COG3590	peptidase
WYH_02099	COG1132	(ABC) transporter
WYH_02101	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WYH_02106	COG0069	glutamate synthase activity
WYH_02106	COG0070	glutamate synthase
WYH_02106	COG0067	glutamate synthase
WYH_02110	COG2175	clavaminate synthase activity
WYH_02111	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WYH_02115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WYH_02117	COG1012	belongs to the aldehyde dehydrogenase family
WYH_02118	COG2957	Belongs to the agmatine deiminase family
WYH_02120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WYH_02121	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WYH_02122	COG2833	Protein of unknown function (DUF455)
WYH_02123	COG0739	heme binding
WYH_02128	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_02131	COG0495	leucyl-tRNA aminoacylation
WYH_02136	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WYH_02137	COG2902	Dehydrogenase
WYH_02139	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WYH_02140	COG4152	abc transporter atp-binding protein
WYH_02145	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
WYH_02148	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_02150	COG2124	cytochrome p450
WYH_02155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WYH_02160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WYH_02161	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_02163	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WYH_02167	COG0776	regulation of translation
WYH_02168	COG2188	Transcriptional regulator
WYH_02169	COG3104	oligopeptide transport
WYH_02170	COG1228	amidohydrolase
WYH_02172	COG0545	Peptidyl-prolyl cis-trans isomerase
WYH_02173	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WYH_02175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_02179	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WYH_02183	COG1473	amidohydrolase
WYH_02185	COG3511	phospholipase C
WYH_02189	COG3507	Belongs to the glycosyl hydrolase 43 family
WYH_02194	COG2115	Belongs to the xylose isomerase family
WYH_02195	COG1070	Carbohydrate kinase
WYH_02199	COG2186	Transcriptional regulator
WYH_02204	COG2755	lipolytic protein G-D-S-L family
WYH_02204	COG0657	acetylesterase activity
WYH_02208	COG0477	Major facilitator Superfamily
WYH_02211	COG3661	Belongs to the glycosyl hydrolase 67 family
WYH_02217	COG3507	Belongs to the glycosyl hydrolase 43 family
WYH_02219	COG0129	dihydroxy-acid dehydratase activity
WYH_02221	COG4566	intracellular signal transduction
WYH_02224	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WYH_02235	COG0501	Belongs to the peptidase M48B family
WYH_02237	COG3275	phosphorelay sensor kinase activity
WYH_02238	COG3279	Response regulator of the LytR AlgR family
WYH_02242	COG0590	tRNA wobble adenosine to inosine editing
WYH_02243	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WYH_02247	COG1570	exodeoxyribonuclease VII activity
WYH_02248	COG0151	Belongs to the GarS family
WYH_02249	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WYH_02253	COG0316	Belongs to the HesB IscA family
WYH_02255	COG2151	metal-sulfur cluster biosynthetic enzyme
WYH_02256	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WYH_02257	COG0719	Fe-S assembly protein
WYH_02258	COG0396	ATPase activity
WYH_02261	COG0719	Fe-S assembly protein
WYH_02262	COG1959	2 iron, 2 sulfur cluster binding
WYH_02263	COG0167	dihydroorotate dehydrogenase activity
WYH_02267	COG2022	thiamine diphosphate biosynthetic process
WYH_02269	COG1612	heme a metabolic process
WYH_02271	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WYH_02272	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WYH_02280	COG3275	phosphorelay sensor kinase activity
WYH_02281	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WYH_02281	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WYH_02287	COG0517	IMP dehydrogenase activity
WYH_02288	COG0316	Belongs to the HesB IscA family
WYH_02294	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WYH_02295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WYH_02296	COG0237	dephospho-CoA kinase activity
WYH_02297	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WYH_02298	COG0424	maF-like protein
WYH_02299	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WYH_02300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WYH_02302	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WYH_02305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WYH_02306	COG0445	tRNA wobble uridine modification
WYH_02307	COG0357	Ribosomal RNA small subunit methyltransferase G
WYH_02308	COG1192	Involved in chromosome partitioning
WYH_02309	COG1475	DNA binding
WYH_02311	COG1956	GAF domain-containing protein
WYH_02314	COG0009	L-threonylcarbamoyladenylate synthase
WYH_02317	COG1329	Transcriptional regulator
WYH_02318	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WYH_02320	COG0739	heme binding
WYH_02321	COG0113	porphobilinogen synthase activity
WYH_02323	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WYH_02324	COG1872	DUF167
WYH_02325	COG0659	secondary active sulfate transmembrane transporter activity
WYH_02326	COG1793	dna ligase
WYH_02331	COG1064	alcohol dehydrogenase
WYH_02337	COG0739	heme binding
WYH_02338	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WYH_02339	COG0667	Aldo Keto reductase
WYH_02340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WYH_02341	COG0799	negative regulation of ribosome biogenesis
WYH_02342	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WYH_02344	COG0793	Belongs to the peptidase S41A family
WYH_02348	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WYH_02349	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WYH_02350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_02351	COG1295	ribonuclease BN
WYH_02352	COG0484	heat shock protein binding
WYH_02353	COG0259	pyridoxamine-phosphate oxidase activity
WYH_02358	COG0482	sulfurtransferase activity
WYH_02364	COG2733	membrane
WYH_02368	COG2086	electron transfer activity
WYH_02369	COG0045	succinate-CoA ligase (ADP-forming) activity
WYH_02370	COG1218	3'(2'),5'-bisphosphate nucleotidase
WYH_02371	COG2885	chlorophyll binding
WYH_02372	COG1253	flavin adenine dinucleotide binding
WYH_02374	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WYH_02375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WYH_02376	COG0196	riboflavin kinase activity
WYH_02378	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WYH_02379	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WYH_02380	COG0588	phosphoglycerate mutase activity
WYH_02389	COG0308	aminopeptidase N
WYH_02393	COG2857	Cytochrome c1
WYH_02393	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WYH_02394	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WYH_02396	COG2885	chlorophyll binding
WYH_02399	COG1858	cytochrome C peroxidase
WYH_02400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WYH_02401	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WYH_02403	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WYH_02405	COG1192	Involved in chromosome partitioning
WYH_02409	COG1201	RNA secondary structure unwinding
WYH_02416	COG1494	fructose-1,6-bisphosphatase
WYH_02421	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WYH_02422	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WYH_02424	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WYH_02425	COG0072	phenylalanine-tRNA ligase activity
WYH_02426	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WYH_02430	COG0004	ammonium transporteR
WYH_02431	COG0004	ammonium transporteR
WYH_02432	COG0347	Belongs to the P(II) protein family
WYH_02433	COG0004	ammonium transporteR
WYH_02434	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WYH_02434	COG2885	chlorophyll binding
WYH_02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_02435	COG3453	Protein conserved in bacteria
WYH_02436	COG1253	flavin adenine dinucleotide binding
WYH_02437	COG1278	Cold shock
WYH_02438	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WYH_02439	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WYH_02440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WYH_02442	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WYH_02443	COG2814	Major facilitator Superfamily
WYH_02456	COG0156	8-amino-7-oxononanoate synthase activity
WYH_02464	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WYH_02468	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WYH_02471	COG1250	3-hydroxyacyl-CoA dehydrogenase
WYH_02472	COG2096	Adenosyltransferase
WYH_02474	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_02476	COG0281	malic enzyme
WYH_02476	COG0280	phosphate acetyltransferase
WYH_02479	COG3550	peptidyl-serine autophosphorylation
WYH_02494	COG4227	nucleotidyltransferase activity
WYH_02497	COG1230	cation diffusion facilitator family transporter
WYH_02505	COG0028	Belongs to the TPP enzyme family
WYH_02506	COG1012	belongs to the aldehyde dehydrogenase family
WYH_02509	COG0672	)-iron permease
WYH_02511	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_02512	COG1131	(ABC) transporter
WYH_02513	COG0842	Transport permease protein
WYH_02514	COG0842	Transport permease protein
WYH_02518	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WYH_02519	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WYH_02520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WYH_02523	COG1960	acyl-CoA dehydrogenase activity
WYH_02524	COG1960	acyl-CoA dehydrogenase activity
WYH_02525	COG2217	Heavy metal translocating P-type atpase
WYH_02527	COG0596	Alpha beta hydrolase
WYH_02527	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_02527	COG2226	methyltransferase
WYH_02528	COG1620	l-lactate permease
WYH_02529	COG0475	glutathione-regulated potassium exporter activity
WYH_02530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_02530	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_02531	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_02536	COG3459	Glycosyltransferase 36 associated
WYH_02543	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WYH_02544	COG0670	Belongs to the BI1 family
WYH_02546	COG0033	Phosphoglucomutase
WYH_02547	COG0129	dihydroxy-acid dehydratase activity
WYH_02548	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WYH_02551	COG0126	phosphoglycerate kinase activity
WYH_02552	COG2801	Transposase and inactivated derivatives
WYH_02552	COG3415	Transposase
WYH_02559	COG3550	peptidyl-serine autophosphorylation
WYH_02569	COG2226	methyltransferase
WYH_02572	COG1937	Protein conserved in bacteria
WYH_02583	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WYH_02586	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_02587	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_02589	COG2132	Multicopper oxidase
WYH_02595	COG3415	Transposase
WYH_02595	COG2801	Transposase and inactivated derivatives
WYH_02597	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WYH_02599	COG0745	RESPONSE REGULATOR receiver
WYH_02600	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WYH_02601	COG1137	ATPase activity
WYH_02603	COG0668	transmembrane transport
WYH_02604	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WYH_02607	COG0124	histidyl-tRNA synthetase
WYH_02608	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WYH_02609	COG2890	protein-(glutamine-N5) methyltransferase activity
WYH_02611	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WYH_02612	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WYH_02613	COG2311	Membrane
WYH_02615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WYH_02618	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WYH_02620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WYH_02620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WYH_02625	COG0459	protein refolding
WYH_02626	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WYH_02627	COG0534	Mate efflux family protein
WYH_02629	COG0222	ribosome binding
WYH_02630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WYH_02631	COG3655	Transcriptional regulator
WYH_02634	COG0085	RNA polymerase activity
WYH_02635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WYH_02636	COG1902	pentaerythritol trinitrate reductase activity
WYH_02637	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WYH_02637	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WYH_02639	COG0717	Belongs to the dCTP deaminase family
WYH_02642	COG0028	Belongs to the TPP enzyme family
WYH_02643	COG2198	Histidine kinase
WYH_02643	COG0643	Histidine kinase
WYH_02645	COG0745	RESPONSE REGULATOR receiver
WYH_02646	COG2201	protein-glutamate methylesterase activity
WYH_02648	COG5001	Diguanylate cyclase
WYH_02651	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_02653	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_02654	COG1012	belongs to the aldehyde dehydrogenase family
WYH_02658	COG4191	Histidine kinase
WYH_02659	COG4566	intracellular signal transduction
WYH_02662	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_02664	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_02665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WYH_02671	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_02672	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_02676	COG0783	Belongs to the Dps family
WYH_02681	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_02682	COG0071	Belongs to the small heat shock protein (HSP20) family
WYH_02683	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WYH_02684	COG0655	NAD(P)H dehydrogenase (quinone) activity
WYH_02687	COG0475	glutathione-regulated potassium exporter activity
WYH_02687	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WYH_02689	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WYH_02693	COG0583	DNA-binding transcription factor activity
WYH_02695	COG2948	multi-organism process
WYH_02697	COG3701	Conjugal transfer protein
WYH_02701	COG3451	type IV secretory pathway VirB4
WYH_02704	COG4962	Type ii secretion system protein e
WYH_02716	COG0741	lytic transglycosylase activity
WYH_02724	COG5489	Protein of unknown function (DUF736)
WYH_02728	COG4227	nucleotidyltransferase activity
WYH_02730	COG5425	PFAM Usg family protein
WYH_02732	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WYH_02733	COG0459	protein refolding
WYH_02734	COG0438	transferase activity, transferring glycosyl groups
WYH_02739	COG0501	Belongs to the peptidase M48B family
WYH_02741	COG3243	poly(R)-hydroxyalkanoic acid synthase
WYH_02745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
WYH_02747	COG0668	transmembrane transport
WYH_02764	COG2884	Cell division ATP-binding protein ftsE
WYH_02766	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WYH_02768	COG0287	Prephenate dehydrogenase
WYH_02769	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WYH_02770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_02771	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_02771	COG2813	Specifically methylates the guanine in position
WYH_02772	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WYH_02774	COG3383	formate dehydrogenase (NAD+) activity
WYH_02778	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WYH_02781	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WYH_02788	COG2032	superoxide dismutase activity
WYH_02790	COG2814	Major facilitator Superfamily
WYH_02791	COG0702	epimerase
WYH_02798	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_02799	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WYH_02801	COG0330	HflC and HflK could
WYH_02802	COG0330	HflC and HflK could
WYH_02803	COG0489	protein tyrosine kinase activity
WYH_02804	COG2010	Cytochrome c
WYH_02804	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WYH_02805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WYH_02809	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WYH_02813	COG1959	2 iron, 2 sulfur cluster binding
WYH_02814	COG5583	Uncharacterized small protein (DUF2292)
WYH_02816	COG0730	response to heat
WYH_02817	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WYH_02820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WYH_02821	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WYH_02822	COG0509	glycine decarboxylation via glycine cleavage system
WYH_02823	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_02824	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WYH_02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_02834	COG4251	negative regulation of phosphorylation
WYH_02840	COG0318	PFAM AMP-dependent synthetase and ligase
WYH_02844	COG4765	Protein conserved in bacteria
WYH_02845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WYH_02848	COG1115	amino acid carrier protein
WYH_02856	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WYH_02857	COG0081	regulation of translation
WYH_02859	COG1546	Belongs to the CinA family
WYH_02859	COG1058	Belongs to the CinA family
WYH_02860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WYH_02862	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WYH_02864	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WYH_02869	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_02871	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_02878	COG1846	Transcriptional regulator
WYH_02897	COG1012	belongs to the aldehyde dehydrogenase family
WYH_02904	COG0248	Ppx GppA phosphatase
WYH_02905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WYH_02906	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WYH_02910	COG3451	type IV secretory pathway VirB4
WYH_02913	COG0739	heme binding
WYH_02913	COG1196	nuclear chromosome segregation
WYH_02913	COG0741	lytic transglycosylase activity
WYH_02921	COG4774	siderophore transport
WYH_02928	COG2271	Major facilitator Superfamily
WYH_02929	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_02930	COG3459	Glycosyltransferase 36 associated
WYH_02932	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WYH_02933	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_02933	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WYH_02938	COG1448	Aminotransferase
WYH_02942	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WYH_02942	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WYH_02945	COG2983	Belongs to the UPF0260 family
WYH_02946	COG1999	signal sequence binding
WYH_02951	COG0629	single-stranded DNA binding
WYH_02955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WYH_02956	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WYH_02959	COG0659	secondary active sulfate transmembrane transporter activity
WYH_02962	COG5265	(ABC) transporter
WYH_02965	COG0463	Glycosyl transferase, family 2
WYH_02973	COG0114	fumarate hydratase activity
WYH_02977	COG1285	pathogenesis
WYH_02980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WYH_02982	COG0730	response to heat
WYH_02983	COG1218	3'(2'),5'-bisphosphate nucleotidase
WYH_02985	COG0175	sulfate reduction
WYH_02986	COG1024	Enoyl-CoA hydratase
WYH_02987	COG1960	acyl-CoA dehydrogenase activity
WYH_02992	COG2030	dehydratase
WYH_02994	COG2376	Dihydroxyacetone kinase
WYH_02996	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WYH_02997	COG0191	fructose-bisphosphate aldolase activity
WYH_03000	COG0582	viral genome integration into host DNA
WYH_03002	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WYH_03003	COG1404	Belongs to the peptidase S8 family
WYH_03004	COG0464	growth
WYH_03011	COG0783	Belongs to the Dps family
WYH_03015	COG2814	Major facilitator Superfamily
WYH_03023	COG4946	Tricorn protease homolog
WYH_03023	COG1506	peptidase
WYH_03023	COG0823	Involved in the tonB-independent uptake of proteins
WYH_03029	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WYH_03032	COG1671	Belongs to the UPF0178 family
WYH_03033	COG2824	Alkylphosphonate utilization operon protein PhnA
WYH_03034	COG1278	Cold shock
WYH_03041	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
WYH_03042	COG1881	PFAM PEBP family protein
WYH_03044	COG3384	dioxygenase
WYH_03046	COG1476	TRANSCRIPTIONal
WYH_03055	COG2171	N-acyltransferase activity
WYH_03057	COG0194	GDP metabolic process
WYH_03060	COG0131	Imidazoleglycerol-phosphate dehydratase
WYH_03061	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WYH_03062	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WYH_03064	COG0107	imidazoleglycerol-phosphate synthase activity
WYH_03065	COG0140	phosphoribosyl-ATP diphosphatase activity
WYH_03067	COG0824	Thioesterase
WYH_03071	COG0823	Involved in the tonB-independent uptake of proteins
WYH_03072	COG2885	chlorophyll binding
WYH_03074	COG0484	heat shock protein binding
WYH_03076	COG0471	metal ion transport
WYH_03078	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WYH_03080	COG0408	coproporphyrinogen oxidase activity
WYH_03090	COG4771	TonB-dependent receptor
WYH_03096	COG1309	transcriptional regulator
WYH_03097	COG0252	asparaginase activity
WYH_03102	COG0745	RESPONSE REGULATOR receiver
WYH_03103	COG2205	protein histidine kinase activity
WYH_03120	COG1741	Belongs to the pirin family
WYH_03130	COG3706	GGDEF domain
WYH_03131	COG4566	intracellular signal transduction
WYH_03133	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WYH_03135	COG1684	flagellar biosynthetic protein fliR
WYH_03136	COG1987	bacterial-type flagellum assembly
WYH_03148	COG1677	Flagellar hook-basal body complex protein FliE
WYH_03149	COG2204	response regulator
WYH_03153	COG1360	Flagellar Motor Protein
WYH_03155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WYH_03156	COG1256	bacterial-type flagellum assembly
WYH_03156	COG4786	Flagellar basal body rod
WYH_03158	COG1706	bacterial-type flagellum-dependent cell motility
WYH_03159	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WYH_03160	COG4786	Flagellar basal body rod
WYH_03162	COG4786	Flagellar basal body rod
WYH_03163	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WYH_03166	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WYH_03173	COG1191	sigma factor activity
WYH_03175	COG0842	Transport permease protein
WYH_03176	COG0842	Transport permease protein
WYH_03177	COG1131	(ABC) transporter
WYH_03179	COG1309	transcriptional regulator
WYH_03180	COG0577	efflux transmembrane transporter activity
WYH_03180	COG1136	(ABC) transporter
WYH_03181	COG1136	(ABC) transporter
WYH_03181	COG0577	efflux transmembrane transporter activity
WYH_03182	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WYH_03188	COG1846	Transcriptional regulator
WYH_03197	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WYH_03201	COG2827	Endonuclease containing a URI domain
WYH_03205	COG0439	Biotin carboxylase
WYH_03206	COG0511	ligase activity, forming carbon-carbon bonds
WYH_03208	COG3848	Pyruvate phosphate dikinase
WYH_03208	COG0574	Belongs to the PEP-utilizing enzyme family
WYH_03209	COG2207	Transcriptional regulator
WYH_03212	COG0745	RESPONSE REGULATOR receiver
WYH_03218	COG0625	glutathione transferase activity
WYH_03219	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WYH_03220	COG1846	Transcriptional regulator
WYH_03221	COG1024	Enoyl-CoA hydratase
WYH_03222	COG0045	succinate-CoA ligase (ADP-forming) activity
WYH_03222	COG1042	CoA-binding domain protein
WYH_03222	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WYH_03225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WYH_03226	COG1960	acyl-CoA dehydrogenase activity
WYH_03228	COG0052	Belongs to the universal ribosomal protein uS2 family
WYH_03232	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WYH_03233	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WYH_03234	COG0181	hydroxymethylbilane synthase activity
WYH_03237	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WYH_03241	COG0556	nucleotide-excision repair
WYH_03244	COG0596	Alpha beta hydrolase
WYH_03244	COG2226	methyltransferase
WYH_03244	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WYH_03245	COG2308	Evidence 4 Homologs of previously reported genes of
WYH_03252	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WYH_03253	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WYH_03280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WYH_03284	COG1012	belongs to the aldehyde dehydrogenase family
WYH_03285	COG1012	belongs to the aldehyde dehydrogenase family
WYH_03286	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WYH_03287	COG1192	Involved in chromosome partitioning
WYH_03288	COG1475	DNA binding
WYH_03300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WYH_03301	COG0589	response to stress
WYH_03312	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WYH_03313	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WYH_03315	COG0671	phosphoesterase, PA-phosphatase related
WYH_03318	COG2244	polysaccharide biosynthetic process
WYH_03326	COG0583	DNA-binding transcription factor activity
WYH_03328	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WYH_03330	COG4771	TonB-dependent receptor
WYH_03333	COG2186	Transcriptional regulator
WYH_03334	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WYH_03335	COG0583	DNA-binding transcription factor activity
WYH_03336	COG1012	belongs to the aldehyde dehydrogenase family
WYH_03337	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WYH_03343	COG1028	Short-chain dehydrogenase reductase Sdr
WYH_03346	COG2086	electron transfer activity
WYH_03347	COG1960	acyl-CoA dehydrogenase activity