locus-tag class description A6F68_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A6F68_00003 ENOG4105D06 uba thif-type nad fad binding protein A6F68_00004 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A6F68_00006 ENOG4105EYW Ion transport protein A6F68_00007 ENOG4105CSM endonuclease III A6F68_00009 ENOG4107QJT sodium dicarboxylate symporter A6F68_00010 ENOG4105CK2 sodium dicarboxylate symporter A6F68_00011 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A6F68_00013 ENOG4108TGY Glutathione S-transferase A6F68_00015 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A6F68_00017 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A6F68_00018 ENOG4105VG0 50S ribosomal protein l34 A6F68_00020 ENOG4105C0P Mg chelatase subunit ChlI A6F68_00027 ENOG4105YK5 50S ribosomal protein L36 A6F68_00033 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A6F68_00034 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) A6F68_00036 ENOG4108ZTZ UPF0262 protein A6F68_00037 ENOG4105CDU Replicative dna helicase A6F68_00038 ENOG4105DZQ phospholipase D Transphosphatidylase A6F68_00039 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) A6F68_00042 ENOG4107R37 Glutamate dehydrogenase A6F68_00043 ENOG4105F8J Adenylate Guanylate cyclase A6F68_00052 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) A6F68_00055 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) A6F68_00059 ENOG4105BZU Histidine kinase A6F68_00060 ENOG4105DG6 mannose-6-phosphate isomerase A6F68_00061 ENOG4105CJT Mannose-1-phosphate guanylyltransferase A6F68_00065 ENOG4105D9N nucleoside A6F68_00067 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A6F68_00069 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A6F68_00070 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A6F68_00071 ENOG4108FN7 Aldo keto reductase A6F68_00072 ENOG4105ETE Transcriptional regulator (LacI family A6F68_00073 ENOG4105CJQ hydrolase, family 31 A6F68_00078 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_00080 ENOG4105CK2 sodium dicarboxylate symporter A6F68_00084 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A6F68_00085 ENOG4105CVM Molybdenum cofactor synthesis domain protein A6F68_00086 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A6F68_00093 ENOG4108ESX Receptor A6F68_00094 ENOG4105CBG Sulfatase A6F68_00095 ENOG4107QK4 glycoside hydrolase, family 3 domain protein A6F68_00096 ENOG4107PP3 Acetylornithine deacetylase A6F68_00099 ENOG41061MV Arylsulfatase A6F68_00102 ENOG4105ETT transcriptional Regulator, LysR family A6F68_00103 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A6F68_00108 ENOG4105C01 Dihydroxy-acid dehydratase A6F68_00110 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F A6F68_00112 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A6F68_00113 ENOG4105F38 ABC transporter, permease A6F68_00114 ENOG4105C26 Dehydrogenase A6F68_00117 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme A6F68_00119 ENOG4105EF7 Transcriptional regulator A6F68_00120 ENOG4105E0K tonB-dependent siderophore receptor A6F68_00121 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein A6F68_00129 ENOG4105DFP Integrase A6F68_00144 ENOG4105C4K Nad synthetase A6F68_00147 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A6F68_00149 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A6F68_00155 ENOG4107RIZ hflk protein A6F68_00156 ENOG4105EPW hflc protein A6F68_00157 ENOG4105C0H protease A6F68_00160 ENOG4105BZ4 penicillin-binding protein A6F68_00161 ENOG4105E0X reductase A6F68_00167 ENOG4107QPD alcohol dehydrogenase A6F68_00170 ENOG4105CI2 imidazolone-5-propionate hydrolase A6F68_00171 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A6F68_00172 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A6F68_00175 ENOG4105VMP Transcriptional regulator A6F68_00177 ENOG4108VZM 50s ribosomal protein L10 A6F68_00178 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A6F68_00180 ENOG4105CKD glutathione-regulated potassium-efflux system protein A6F68_00181 ENOG4105XUA cytochrome c A6F68_00183 ENOG4107QI1 Mate efflux family protein A6F68_00184 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A6F68_00185 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A6F68_00189 ENOG4105C2M dna polymerase I A6F68_00190 ENOG410903D sensor protein A6F68_00199 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A6F68_00200 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) A6F68_00202 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A6F68_00203 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A6F68_00204 ENOG4105CUT histidyl-tRNA synthetase A6F68_00206 ENOG4105F0N pyrophosphate phospho-hydrolase A6F68_00207 ENOG4105D64 Mechanosensitive ion channel A6F68_00208 ENOG4105CMS peptidase U62, modulator of DNA gyrase A6F68_00210 ENOG4108IUZ ABC transporter A6F68_00211 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6F68_00212 ENOG4105EFQ Two component transcriptional regulator (Winged helix family A6F68_00213 ENOG410635A Membrane A6F68_00214 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A6F68_00219 ENOG4105C6K Malic enzyme A6F68_00220 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A6F68_00224 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A6F68_00225 ENOG4108WBT adenosyltransferase A6F68_00227 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) A6F68_00230 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) A6F68_00232 ENOG4105DEF Extracellular solute-binding protein, family 5 A6F68_00234 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters A6F68_00241 ENOG4108UXN response regulator A6F68_00244 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A6F68_00245 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A6F68_00252 ENOG4105EYW Ion transport protein A6F68_00254 ENOG41080HT Transcriptional regulator, arsr family A6F68_00255 ENOG4108V62 Rhodanese domain protein A6F68_00257 ENOG4108UM1 dedA family A6F68_00261 ENOG4105EFC phage portal protein HK97 family A6F68_00277 ENOG4105KCK Peptidoglycan-associated lipoprotein A6F68_00278 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A6F68_00280 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A6F68_00282 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A6F68_00283 ENOG4105DBV ornithine carbamoyltransferase A6F68_00284 ENOG4105C8Y Acetylornithine aminotransferase A6F68_00286 ENOG4105EE5 Membrane protein terC A6F68_00288 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B A6F68_00293 ENOG4105BZU Histidine kinase A6F68_00294 ENOG4108YZA Nitrogen regulatory protein pii A6F68_00297 ENOG4105D7A ATP-binding protein A6F68_00300 ENOG4108YZN class I peptide chain release factor A6F68_00301 ENOG4105W0E 50S ribosomal protein L33 A6F68_00304 ENOG4107QJN gtp cyclohydrolase ii A6F68_00305 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A6F68_00306 ENOG4105DJ4 phosphatidylserine decarboxylase A6F68_00310 ENOG4105F6J Alpha beta hydrolase fold A6F68_00314 ENOG4105DU1 integral membrane protein, terc A6F68_00316 ENOG4105C9U ATP-dependent DNA helicase RecQ A6F68_00320 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F A6F68_00321 ENOG4105CHU acetyl-coa acetyltransferase A6F68_00322 ENOG4105MIR Phenylalanine 4-monooxygenase A6F68_00325 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A6F68_00326 ENOG4105BZ1 (ABC) transporter A6F68_00329 ENOG4105CHU acetyl-coa acetyltransferase A6F68_00333 ENOG4105CPK Glycosyl transferase (Group 1 A6F68_00338 ENOG4105VJY transcriptional regulator A6F68_00339 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A6F68_00346 ENOG4105C8T Leucyl-tRNA synthetase A6F68_00347 ENOG4105TXM Domain of unknown function (DUF3576) A6F68_00349 ENOG4105CHR reductase A6F68_00350 ENOG4105UYK outer membrane protein a A6F68_00354 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A6F68_00356 ENOG4105D85 methylase A6F68_00358 ENOG4105DR5 peptidase A6F68_00359 ENOG4105ED9 Protein of unknown function (DUF455) A6F68_00360 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A6F68_00361 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) A6F68_00363 ENOG4105DWY Agmatine deiminase A6F68_00366 ENOG4105C22 threonyL-tRNA synthetase A6F68_00371 ENOG4105DEN Luciferase family A6F68_00372 ENOG4105C7I Dehydrogenase A6F68_00374 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A6F68_00375 ENOG4108IUX (ABC) transporter A6F68_00378 ENOG4105E0X reductase A6F68_00382 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A6F68_00385 ENOG4105JAB phenazine biosynthesis protein, phzf family A6F68_00386 ENOG41076HS cation diffusion facilitator family transporter A6F68_00387 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A6F68_00388 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A6F68_00389 ENOG4107U9T Pfam:Ribonuclease_BN A6F68_00390 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A6F68_00393 ENOG4105D3Q Sugar transferase A6F68_00399 ENOG4105C1B dTDP-glucose 4-6-dehydratase A6F68_00402 ENOG4105D75 Capsular exopolysaccharide family A6F68_00404 ENOG4105C5E polysaccharide biosynthesis protein A6F68_00405 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A6F68_00410 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A6F68_00414 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A6F68_00415 ENOG4106448 streptomycin biosynthesis protein strI A6F68_00416 ENOG4105D2T synthase A6F68_00418 ENOG4105F0R Cytidylyltransferase A6F68_00423 ENOG4105D7W serine acetyltransferase A6F68_00429 ENOG4105CN1 protease A6F68_00431 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A6F68_00433 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A6F68_00434 ENOG4105CPC Aldo Keto reductase A6F68_00435 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A6F68_00436 ENOG4105DR5 peptidase A6F68_00439 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_00446 ENOG4107T0X DNA ligase A6F68_00448 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) A6F68_00450 ENOG4108Z0R Transferase A6F68_00452 ENOG4108YYQ gCN5-related N-acetyltransferase A6F68_00453 ENOG4105D52 delta-aminolevulinic acid dehydratase A6F68_00454 ENOG4105DR5 peptidase A6F68_00457 ENOG4108Z4U Ferredoxin A6F68_00458 ENOG4108VJ1 Transcriptional regulator (CarD family A6F68_00461 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A6F68_00462 ENOG4105CSU acyl-Coa dehydrogenase A6F68_00471 ENOG4105FA0 parb-like partition protein A6F68_00472 ENOG4107QJE Chromosome Partitioning Protein A6F68_00473 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) A6F68_00474 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) A6F68_00475 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A6F68_00481 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A6F68_00483 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A6F68_00484 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) A6F68_00485 ENOG4108UHJ MAF-like protein A6F68_00486 ENOG4105E2X shikimate dehydrogenase A6F68_00487 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A6F68_00489 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea A6F68_00490 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN A6F68_00494 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A6F68_00501 ENOG4107GFK fumarate A6F68_00502 ENOG4108HRK Histidine kinase A6F68_00503 ENOG4108VAC response regulator A6F68_00508 ENOG4108UJD 30S ribosomal protein S9 A6F68_00509 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A6F68_00511 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) A6F68_00513 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) A6F68_00519 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A6F68_00520 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) A6F68_00529 ENOG4105JRK feS assembly protein SufD A6F68_00531 ENOG4105VG1 fes assembly suf system protein A6F68_00532 ENOG4108Z4V iron-sulfur cluster assembly A6F68_00538 ENOG4105C12 Phosphoribosylglycinamide synthetase A6F68_00539 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A6F68_00542 ENOG4105KDC 50s ribosomal protein l28 A6F68_00543 ENOG4108Z6B deaminase A6F68_00546 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A6F68_00547 ENOG4108NEV two component transcriptional regulator, LytTR family A6F68_00548 ENOG4108HRK Histidine kinase A6F68_00552 ENOG4105D0M Protease HtpX homolog A6F68_00561 ENOG4105NHS Transcriptional regulator, TraR DksA family A6F68_00569 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6F68_00570 ENOG4106F60 Histidine kinase A6F68_00571 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) A6F68_00572 ENOG4105EMU Dehydrogenase A6F68_00574 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A6F68_00575 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A6F68_00580 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A6F68_00581 ENOG41082BR 50S ribosomal protein L35 A6F68_00583 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A6F68_00590 ENOG4105CBT Fructose-1,6-bisphosphatase A6F68_00593 ENOG4105D6E homoserine dehydrogenase A6F68_00597 ENOG4105M8F Biopolymer transport protein exbD tolR A6F68_00601 ENOG4107QRT dEAD DEAH box helicase A6F68_00607 ENOG4107SKI cobyrinic Acid a,c-diamide synthase A6F68_00608 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) A6F68_00610 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A6F68_00611 ENOG4105EIX cytochrome c1 A6F68_00612 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A6F68_00613 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A6F68_00614 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A6F68_00615 ENOG4105CD8 aminopeptidase N A6F68_00624 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A6F68_00626 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A6F68_00628 ENOG4105DTN riboflavin biosynthesis protein ribF A6F68_00630 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A6F68_00634 ENOG4105ECY inositol monophosphatase A6F68_00635 ENOG4105CMV Succinyl-CoA synthetase subunit beta A6F68_00636 ENOG4105BZJ Electron transfer flavoprotein A6F68_00637 ENOG4105C10 Electron transfer flavoprotein A6F68_00640 ENOG4106BRA Membrane A6F68_00642 ENOG4105DJY efflux transporter, rnd family, mfp subunit A6F68_00645 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) A6F68_00649 ENOG4105FDP GntR family transcriptional regulator A6F68_00650 ENOG4105DUX Transporter A6F68_00651 ENOG4105CI2 imidazolone-5-propionate hydrolase A6F68_00653 ENOG4108V1T peptidylprolyl cis-trans isomerase A6F68_00654 ENOG410903C (LipO)protein A6F68_00656 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A6F68_00659 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A6F68_00663 ENOG4105DC1 bifunctional purine biosynthesis protein purh A6F68_00665 ENOG4105DJV ribulose-phosphate 3-epimerase A6F68_00669 ENOG4105CH2 amidohydrolase A6F68_00670 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_00671 ENOG4105C26 Dehydrogenase A6F68_00673 ENOG4108ESX Receptor A6F68_00674 ENOG4105DHP deoxycytidine triphosphate deaminase A6F68_00675 ENOG4105EG6 Saccharopine dehydrogenase A6F68_00679 ENOG4107QR8 Thioredoxin A6F68_00681 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein A6F68_00683 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A6F68_00685 ENOG4105CAS nag kinase A6F68_00692 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A6F68_00694 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A6F68_00697 ENOG4105DUX Transporter A6F68_00698 ENOG4108IYU L-aspartate oxidase A6F68_00701 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) A6F68_00702 ENOG4105DA5 (ABC) transporter A6F68_00704 ENOG4105D1U peptidase U62 modulator of DNA gyrase A6F68_00710 ENOG4105CSM endonuclease III A6F68_00712 ENOG4105DBI uridine monophosphokinase A6F68_00717 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_00718 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) A6F68_00720 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A6F68_00721 ENOG4107T31 5'-nucleotidase A6F68_00726 ENOG4107QX3 carboxylase A6F68_00728 ENOG4105C1G acyl-Coa dehydrogenase A6F68_00729 ENOG410903D sensor protein A6F68_00730 ENOG4108IJ8 ABC transporter A6F68_00731 ENOG4105E90 ABC transporter A6F68_00734 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A6F68_00735 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_00736 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) A6F68_00738 ENOG4105DFA alanine racemase domain protein A6F68_00739 ENOG4108UB3 Thiamine monophosphate A6F68_00743 ENOG4106MAR Phosphate-selective porin O and P A6F68_00744 ENOG4105DCF alanine dehydrogenase A6F68_00746 ENOG4105CAK Cell division ATP-binding protein ftsE A6F68_00751 ENOG4105CIH Imidazole acetol-phosphate transaminase A6F68_00753 ENOG4105DWV Homoserine O-trans-acetylase A6F68_00755 ENOG4107EJG GntR family transcriptional regulator A6F68_00756 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 A6F68_00757 ENOG4108RTU Aldolase A6F68_00760 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A6F68_00761 ENOG4105CA9 Pyruvate kinase A6F68_00763 ENOG4105Y2X UPF0335 protein A6F68_00765 ENOG4105CDY transcriptional regulatory protein A6F68_00767 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) A6F68_00769 ENOG4105KUZ arsenate reductase A6F68_00770 ENOG4106Z1T Nicotinamide Mononucleotide Transporter A6F68_00772 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase A6F68_00773 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A6F68_00774 ENOG4105CFH Aspartokinase A6F68_00775 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A6F68_00776 ENOG4105EA8 2-Nitropropane dioxygenase A6F68_00782 ENOG4105CPC Aldo Keto reductase A6F68_00784 ENOG4107QX8 SPFH domain, Band 7 family protein A6F68_00788 ENOG4105DFP Integrase A6F68_00789 ENOG4105G63 Type III effector Hrp-dependent A6F68_00790 ENOG4105FB2 class II Aldolase A6F68_00792 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A6F68_00794 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) A6F68_00795 ENOG41073TP transcriptional regulator A6F68_00796 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 A6F68_00807 ENOG4105CBG Sulfatase A6F68_00808 ENOG4105CBG Sulfatase A6F68_00809 ENOG4105DT9 hydrolase family 43 A6F68_00813 ENOG4105DT9 hydrolase family 43 A6F68_00814 ENOG4105CBG Sulfatase A6F68_00815 ENOG4105ENH Sulfatase A6F68_00821 ENOG4105CBG Sulfatase A6F68_00830 ENOG4107EJG GntR family transcriptional regulator A6F68_00831 ENOG4105C01 Dihydroxy-acid dehydratase A6F68_00835 ENOG4105C01 Dihydroxy-acid dehydratase A6F68_00836 ENOG4105FGE Short-chain dehydrogenase reductase Sdr A6F68_00837 ENOG4107EJG GntR family transcriptional regulator A6F68_00842 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap A6F68_00846 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) A6F68_00847 ENOG4105CBG Sulfatase A6F68_00850 ENOG4105C26 Dehydrogenase A6F68_00851 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A6F68_00853 ENOG4108M9J MaoC like domain protein A6F68_00859 ENOG4105DR5 peptidase A6F68_00864 ENOG4108ZF3 Phosphatase A6F68_00868 ENOG4105CS6 Rhs element vgr protein A6F68_00869 ENOG4105CDV Ompa motb domain protein A6F68_00875 ENOG4106PZD Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway A6F68_00878 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A6F68_00887 ENOG4105BZ1 (ABC) transporter A6F68_00889 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A6F68_00894 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) A6F68_00901 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A6F68_00909 ENOG4105CHU acetyl-coa acetyltransferase A6F68_00911 ENOG410846T CoA-transferase family III A6F68_00913 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) A6F68_00915 ENOG4105C1G acyl-Coa dehydrogenase A6F68_00917 ENOG4105KT7 mgtC SapB transporter A6F68_00923 ENOG4107RCI amp-dependent synthetase and ligase A6F68_00927 ENOG4106ECF Uncharacterized protein conserved in bacteria (DUF2155) A6F68_00928 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) A6F68_00931 ENOG4105PM1 preprotein translocase subunit SecE A6F68_00932 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A6F68_00934 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A6F68_00935 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) A6F68_00938 ENOG4107TH8 cina domain protein A6F68_00939 ENOG4105CT3 Monooxygenase A6F68_00943 ENOG4105BZU Histidine kinase A6F68_00944 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A6F68_00945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6F68_00947 ENOG4105CBS Chea signal transduction histidine kinase A6F68_00952 ENOG4105MP9 class II Aldolase A6F68_00953 ENOG4108XHQ (2Fe-2S)-binding domain protein A6F68_00954 ENOG4105E0K tonB-dependent siderophore receptor A6F68_00955 ENOG4105K89 arsenate reductase A6F68_00959 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A6F68_00961 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A6F68_00963 ENOG4105EXU Membrane A6F68_00964 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) A6F68_00967 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A6F68_00968 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A6F68_00975 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A6F68_00976 ENOG41069FZ L,D-transpeptidase catalytic domain A6F68_00979 ENOG4105CI0 Citrate lyase A6F68_00988 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6F68_00992 ENOG4105E4C Lytic transglycosylase catalytic A6F68_00995 ENOG4105EJX conjugal transfer ATPase A6F68_00999 ENOG4108EHY type IV secretion system A6F68_01011 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A6F68_01014 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A6F68_01015 ENOG4108TGP Thioesterase superfamily protein A6F68_01019 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) A6F68_01027 ENOG41087YS Phage shock protein A A6F68_01029 ENOG4105E51 psp operon transcriptional activator A6F68_01031 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A6F68_01036 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A6F68_01037 ENOG4105CFC Transporter A6F68_01038 ENOG4107104 thymidine kinase A6F68_01039 ENOG4108Z4T Peptidase M50 A6F68_01040 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A6F68_01041 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A6F68_01042 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A6F68_01043 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A6F68_01048 ENOG4105E3A (ABC) transporter A6F68_01058 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_01061 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_01070 ENOG4105D2S major facilitator superfamily A6F68_01071 ENOG4107XC4 flavin reductase domain protein, FMN-binding A6F68_01072 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) A6F68_01074 ENOG4107QP7 CoA-transferase subunit A A6F68_01076 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme A6F68_01077 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) A6F68_01081 ENOG4105KHM amidohydrolase 2 A6F68_01084 ENOG4105JSC dimethylmenaquinone methyltransferase A6F68_01086 ENOG4105GAK amidohydrolase 2 A6F68_01092 ENOG4107RRE RNA-directed DNA polymerase A6F68_01097 ENOG4105EYM Major Facilitator superfamily A6F68_01102 ENOG4105E3B Multicopper oxidase A6F68_01104 ENOG4108Z7R Chaperone CsaA A6F68_01105 ENOG4105D4P Coproporphyrinogen iii oxidase A6F68_01111 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) A6F68_01115 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A6F68_01117 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A6F68_01119 ENOG4105C1G acyl-Coa dehydrogenase A6F68_01122 ENOG4107RUZ Sss sodium solute transporter superfamily A6F68_01125 ENOG4108ZAF Molybdopterin A6F68_01138 ENOG4105CGF Aromatic amino acid aminotransferase A6F68_01143 ENOG4105C31 Tryptophanyl-tRNA synthetase A6F68_01144 ENOG4105CJR Integral membrane protein (MviN A6F68_01145 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) A6F68_01152 ENOG4105CH6 catalase A6F68_01153 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) A6F68_01155 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) A6F68_01157 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A6F68_01158 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A6F68_01160 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A6F68_01165 ENOG41082J7 Rhodanese domain protein A6F68_01166 ENOG4108I0Z Aconitate hydratase A6F68_01168 ENOG4105DIT ErfK YbiS YcfS YnhG family protein A6F68_01177 ENOG4105D44 asparaginase A6F68_01178 ENOG4108J4B Beta-lactamase A6F68_01179 ENOG4105I4A GCN5-related N-acetyltransferase A6F68_01185 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A6F68_01188 ENOG4105CQC Prephenate dehydratase A6F68_01189 ENOG4105XUA cytochrome c A6F68_01191 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) A6F68_01195 ENOG4105DWF phosphomethylpyrimidine kinase A6F68_01196 ENOG4105XDF Protein of unknown function (DUF1272) A6F68_01197 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A6F68_01203 ENOG410903D sensor protein A6F68_01204 ENOG41074H6 response regulator A6F68_01206 ENOG41074H6 response regulator A6F68_01213 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) A6F68_01215 ENOG4105VUH addiction module killer protein A6F68_01218 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class A6F68_01219 ENOG4105CHM Aminotransferase A6F68_01223 ENOG4105W5Q DNA repair protein (RadC A6F68_01224 ENOG4105D0A hydroxylase A6F68_01231 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A6F68_01236 ENOG4108ZXC Two component transcriptional regulator, luxr family A6F68_01238 ENOG4105CK7 Sodium proline symporter A6F68_01244 ENOG4105E18 UPF0276 protein A6F68_01246 ENOG4105CI3 gtp-binding protein typa A6F68_01247 ENOG4105D05 Receptor A6F68_01248 ENOG4105KAF membrAne A6F68_01251 ENOG4108I0Y (ABC) transporter A6F68_01252 ENOG4108UJV acyl-CoA thioesterase i A6F68_01253 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) A6F68_01254 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A6F68_01258 ENOG4105C28 cystathionine A6F68_01262 ENOG410903D sensor protein A6F68_01263 ENOG4105NWN ApaG protein A6F68_01273 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A6F68_01274 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A6F68_01275 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A6F68_01276 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A6F68_01277 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) A6F68_01278 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A6F68_01279 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A6F68_01280 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A6F68_01281 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A6F68_01282 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A6F68_01283 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A6F68_01284 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A6F68_01285 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A6F68_01286 ENOG41083MP 50s ribosomal protein l29 A6F68_01287 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A6F68_01288 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) A6F68_01289 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) A6F68_01290 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A6F68_01291 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A6F68_01292 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A6F68_01293 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A6F68_01294 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A6F68_01295 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A6F68_01296 ENOG41084HQ 50S ribosomal protein L30 A6F68_01297 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A6F68_01298 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A6F68_01299 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A6F68_01301 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A6F68_01302 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A6F68_01303 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A6F68_01304 ENOG4108ZT0 50S ribosomal protein l17 A6F68_01308 ENOG4105EN6 Membrane A6F68_01312 ENOG4107QN2 dihydrolipoyl dehydrogenase A6F68_01314 ENOG4105C7S Dehydrogenase A6F68_01315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A6F68_01317 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A6F68_01322 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_01324 ENOG4108IHU transport system permease protein A6F68_01325 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) A6F68_01326 ENOG41081HM 2'-5' rna ligase A6F68_01327 ENOG4105C9K Endothelin-converting enzyme 1 A6F68_01337 ENOG4105CDH Citrulline--aspartate ligase A6F68_01339 ENOG4108J2P Alpha beta hydrolase fold A6F68_01342 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A6F68_01343 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A6F68_01344 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) A6F68_01345 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) A6F68_01349 ENOG4105JAB phenazine biosynthesis protein, phzf family A6F68_01350 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A6F68_01355 ENOG4108RRZ Transcription elongation factor GreB A6F68_01356 ENOG4105E4C Lytic transglycosylase catalytic A6F68_01357 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A6F68_01359 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A6F68_01366 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A6F68_01371 ENOG4107G43 radical SAM domain protein A6F68_01372 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A6F68_01378 ENOG4105CQB FAD linked oxidase domain protein A6F68_01381 ENOG4105DQE DNA ligase A6F68_01382 ENOG4105FDF Could be involved in DNA repair (By similarity) A6F68_01383 ENOG4105C4R Atp-dependent dna helicase A6F68_01385 ENOG4106H78 methyltransferase A6F68_01386 ENOG4105FE9 pseudouridine synthase A6F68_01387 ENOG4105DVW rieske (2Fe-2S) A6F68_01388 ENOG4105EYM Major Facilitator superfamily A6F68_01389 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A6F68_01390 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) A6F68_01391 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) A6F68_01393 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A6F68_01394 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase A6F68_01395 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A6F68_01398 ENOG4105W5Q DNA repair protein (RadC A6F68_01409 ENOG4105DQ4 alcohol dehydrogenase A6F68_01410 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A6F68_01411 ENOG4105CY3 ABC transporter, permease A6F68_01412 ENOG4105DHJ ABC, transporter A6F68_01418 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A6F68_01420 ENOG4105EI2 Pseudouridine synthase A6F68_01421 ENOG41082CG Protein CrcB homolog A6F68_01422 ENOG4105K5G 30S ribosomal protein S21 A6F68_01423 ENOG4108V1T peptidylprolyl cis-trans isomerase A6F68_01424 ENOG4108MAJ Membrane A6F68_01425 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A6F68_01426 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A6F68_01428 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A6F68_01432 ENOG4105BZU Histidine kinase A6F68_01434 ENOG4105C29 acyl-CoA thioesterase A6F68_01437 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for A6F68_01438 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) A6F68_01439 ENOG4107XZX Involved in the transcription termination process (By similarity) A6F68_01441 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A6F68_01444 ENOG4105D74 hydrolase A6F68_01445 ENOG4108IXY short-chain dehydrogenase reductase A6F68_01446 ENOG4105EUB pirin domain protein A6F68_01454 ENOG4105KCV RNA signal recognition particle 4.5S RNA A6F68_01459 ENOG4108JQC penicillin-binding protein 1A A6F68_01464 ENOG4105C7B Threonine dehydratase A6F68_01465 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate A6F68_01466 ENOG4105CFU surface antigen A6F68_01472 ENOG4105VZ8 Transcriptional regulator A6F68_01474 ENOG4105C5F glutamine synthetase A6F68_01476 ENOG4107SQ0 N-acetyl-gamma-glutamyl-phosphate reductase A6F68_01480 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A6F68_01482 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A6F68_01484 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) A6F68_01485 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) A6F68_01486 ENOG4105KZX Pterin carbinolamine dehydratase A6F68_01487 ENOG4105CHR reductase A6F68_01491 ENOG4105C6T cysteine synthase A6F68_01494 ENOG4107YUR Cell division protein mraZ A6F68_01495 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A6F68_01500 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A6F68_01501 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A6F68_01503 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A6F68_01504 ENOG4105DFU Cell wall formation (By similarity) A6F68_01505 ENOG4105D4A Cell wall formation (By similarity) A6F68_01506 ENOG4105CPF Cell wall formation (By similarity) A6F68_01507 ENOG4108UFP Essential cell division protein (By similarity) A6F68_01508 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A6F68_01509 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A6F68_01512 ENOG4105II7 pyrroline-5-carboxylate reductase A6F68_01513 ENOG4105HFZ Membrane A6F68_01516 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A6F68_01517 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A6F68_01521 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) A6F68_01525 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A6F68_01526 ENOG4105D64 Mechanosensitive ion channel A6F68_01527 ENOG4105C28 cystathionine A6F68_01528 ENOG4105KHC sulfurtransferase A6F68_01530 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) A6F68_01533 ENOG4105C9Q fumarate hydratase class II A6F68_01536 ENOG4105D1H recombination factor protein RarA A6F68_01537 ENOG4105NTW Transcriptional regulator A6F68_01539 ENOG4105BZF Glycosyl transferase (Group 1 A6F68_01540 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A6F68_01542 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) A6F68_01547 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A6F68_01551 ENOG4108VYJ response regulator receiver protein A6F68_01553 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A6F68_01556 ENOG4105CH7 arginosuccinase A6F68_01557 ENOG4107ZT5 Thiol disulfide interchange protein A6F68_01560 ENOG4105HDK L-asparaginase A6F68_01562 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A6F68_01563 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A6F68_01564 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A6F68_01565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A6F68_01569 ENOG4108RWN rrna methyltransferase A6F68_01571 ENOG4108EQA pts system A6F68_01572 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A6F68_01573 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) A6F68_01574 ENOG4105EB3 Histidine kinase A6F68_01575 ENOG4105E3W Two component transcriptional regulator (Winged helix family A6F68_01576 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase A6F68_01582 ENOG4105DHZ alpha beta A6F68_01584 ENOG4105C3J Cysteine desulfurase A6F68_01588 ENOG4108Z0Z intracellular protease Pfpi family A6F68_01589 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A6F68_01591 ENOG4105DJ0 Poly(A) Polymerase A6F68_01592 ENOG4105P8F nudix hydrolase A6F68_01595 ENOG4105D8V Glucose sorbosone dehydrogenase A6F68_01596 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A6F68_01600 ENOG4105EEI dihydropteroate synthase A6F68_01602 ENOG4105CHR reductase A6F68_01603 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A6F68_01605 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A6F68_01606 ENOG4105W8H transhydrogenase (subunit alpha A6F68_01607 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A6F68_01609 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A6F68_01613 ENOG4108MUZ hydrolase A6F68_01615 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin A6F68_01618 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A6F68_01619 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A6F68_01622 ENOG4105C3F Signal peptidase i A6F68_01623 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) A6F68_01625 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A6F68_01627 ENOG4105BZ9 Cytochrome C oxidase, subunit I A6F68_01629 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A6F68_01631 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) A6F68_01632 ENOG4107QS1 Cytochrome C Oxidase, Subunit III A6F68_01635 ENOG4105D98 threonine synthase A6F68_01641 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A6F68_01642 ENOG4105K46 50S ribosomal protein l27 A6F68_01653 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A6F68_01657 ENOG4105C1G acyl-Coa dehydrogenase A6F68_01659 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A6F68_01660 ENOG4105X7H acyl-CoA dehydrogenase A6F68_01661 ENOG4105C1G acyl-Coa dehydrogenase A6F68_01662 ENOG4105CHR reductase A6F68_01668 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A6F68_01671 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A6F68_01673 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A6F68_01674 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A6F68_01676 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase A6F68_01677 ENOG4105K59 histidine triad (HIT) protein A6F68_01678 ENOG4107YD3 Thioesterase A6F68_01679 ENOG4105E02 MotA TolQ exbB proton channel A6F68_01680 ENOG4105SG9 biopolymer transport protein, ExbD A6F68_01682 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) A6F68_01683 ENOG4105KCK Peptidoglycan-associated lipoprotein A6F68_01685 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A6F68_01689 ENOG4105C8P )-transporter A6F68_01695 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) A6F68_01696 ENOG4106A3M Cytochrome p-450 A6F68_01698 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A6F68_01699 ENOG4105C4M (Ubiquinol oxidase) subunit I A6F68_01702 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A6F68_01709 ENOG4105ETE Transcriptional regulator (LacI family A6F68_01711 ENOG4105CHR reductase A6F68_01714 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A6F68_01716 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A6F68_01719 ENOG4107YCY Transcriptional regulator A6F68_01721 ENOG4105EY3 heparinase II III family protein A6F68_01722 ENOG4105DPW Major facilitator superfamily MFS_1 A6F68_01723 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A6F68_01724 ENOG4105CHU acetyl-coa acetyltransferase A6F68_01726 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_01729 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_01733 ENOG4105EA8 2-Nitropropane dioxygenase A6F68_01736 ENOG4105CYM Glutathione S-transferase A6F68_01738 ENOG4108DWA Nad synthetase A6F68_01742 ENOG4105CM2 brancheD-chain amino acid aminotransferase A6F68_01744 ENOG4105DX0 Hemolysin A A6F68_01745 ENOG4105KAV tspo and mbr like protein A6F68_01748 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A6F68_01756 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A6F68_01759 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) A6F68_01762 ENOG4107QP3 malate synthase g A6F68_01765 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A6F68_01766 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A6F68_01767 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) A6F68_01768 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) A6F68_01769 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A6F68_01771 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A6F68_01773 ENOG4108SVW integral membrane protein A6F68_01775 ENOG4108V3E phosphoribosylglycinamide formyltransferase A6F68_01776 ENOG4105CXB phosphoribosylaminoimidazole synthetase A6F68_01778 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) A6F68_01779 ENOG4105D7W serine acetyltransferase A6F68_01781 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr A6F68_01782 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A6F68_01783 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A6F68_01787 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A6F68_01788 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A6F68_01789 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A6F68_01790 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A6F68_01791 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A6F68_01794 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A6F68_01795 ENOG4105CR4 methylisocitrate lyase A6F68_01800 ENOG4105C25 Primosomal protein n' A6F68_01802 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A6F68_01805 ENOG4105C8N cysteinyl-tRNA synthetase A6F68_01806 ENOG4108JQ1 Dehydrogenase A6F68_01807 ENOG4105C7K acetolactate synthase A6F68_01813 ENOG4105C5X domain protein A6F68_01821 ENOG41082R8 50S ribosomal protein l32 A6F68_01822 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) A6F68_01823 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A6F68_01824 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A6F68_01825 ENOG4105WJX transcriptional regulator MERR family A6F68_01830 ENOG4105CEN a g-specific adenine glycosylase A6F68_01833 ENOG4105E09 nadh pyrophosphatase A6F68_01836 ENOG4105CJW magnesium transporter A6F68_01837 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A6F68_01838 ENOG4105EU9 A6F68_01840 ENOG4105C37 (CBS) domain A6F68_01841 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A6F68_01842 ENOG4105C9A Phoh family A6F68_01844 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A6F68_01846 ENOG41090R7 Ferric uptake A6F68_01847 ENOG4108YXV Transcriptional regulator A6F68_01848 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A6F68_01849 ENOG41072GX Peptidase M22 Glycoprotease A6F68_01850 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) A6F68_01851 ENOG41083MR nifu domain-containing protein A6F68_01853 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase A6F68_01854 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A6F68_01855 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process A6F68_01856 ENOG41067HS methyltransferase A6F68_01859 ENOG4105C3M thioredoxin reductase A6F68_01863 ENOG4105E3Q saccharopine dehydrogenase A6F68_01867 ENOG4105E2B Taurine dioxygenase A6F68_01869 ENOG4105BZU Histidine kinase A6F68_01870 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_01871 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A6F68_01872 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A6F68_01873 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A6F68_01874 ENOG4105C79 DNA protecting protein DprA A6F68_01877 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A6F68_01879 ENOG4105C3F Signal peptidase i A6F68_01880 ENOG4107QP8 phosphohexose isomerase A6F68_01882 ENOG4105C1J atp-dependent rna helicase A6F68_01885 ENOG4108VHC Short-chain dehydrogenase reductase Sdr A6F68_01886 ENOG4107QX3 carboxylase A6F68_01889 ENOG4108UKI Enoyl-CoA hydratase A6F68_01890 ENOG4108RXX maleylacetoacetate isomerase A6F68_01893 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A6F68_01897 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) A6F68_01898 ENOG4105D49 3-dehydroquinate synthase A6F68_01899 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A6F68_01902 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A6F68_01903 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) A6F68_01904 ENOG4105ERG peptidase m48, ste24p A6F68_01907 ENOG4105M6F mutator MutT protein A6F68_01910 ENOG4105EUJ GTP cyclohydrolase i A6F68_01912 ENOG4105EHV domain protein A6F68_01914 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) A6F68_01915 ENOG4105I8F Histidine kinase A6F68_01916 ENOG4105K8N protein family UPF0079, ATPase A6F68_01917 ENOG4105EHM Aminoglycoside phosphotransferase A6F68_01918 ENOG4108S0S Nucleotidyl transferase A6F68_01920 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A6F68_01926 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A6F68_01930 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A6F68_01935 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A6F68_01938 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A6F68_01940 ENOG4105CHR reductase A6F68_01941 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) A6F68_01943 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) A6F68_01949 ENOG4105DMF Dehydrogenase A6F68_01950 ENOG4105NA0 Transcriptional regulator A6F68_01953 ENOG4105CGZ zinc metallopeptidase A6F68_01957 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A6F68_01959 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A6F68_01961 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein A6F68_01962 ENOG4105DQU oxidoreductase, subunit beta A6F68_01965 ENOG4105CVP deoxyribo-dipyrimidine photolyase A6F68_01966 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A6F68_01968 ENOG4105EMU Dehydrogenase A6F68_01969 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase A6F68_01970 ENOG4105D60 lipoprotein releasing system transmembrane protein A6F68_01971 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A6F68_01974 ENOG4105C0B DNA polymerase III (alpha subunit) A6F68_01975 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_01981 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A6F68_01983 ENOG4105EHZ conserved protein UCP016719 A6F68_01984 ENOG4105F27 Major Facilitator A6F68_01987 ENOG4108N3W hemolysin secretion protein A6F68_01989 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A6F68_01990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A6F68_01992 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A6F68_01993 ENOG41082FP UPF0102 protein A6F68_01994 ENOG4105D7Z glutathione synthase A6F68_01995 ENOG4105ED2 Beta-lactamase A6F68_01996 ENOG4105K9Q Binds to the 23S rRNA (By similarity) A6F68_01997 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A6F68_01998 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A6F68_01999 ENOG4105CKW Inner membrane protein yedI A6F68_02000 ENOG4105DFU Cell wall formation (By similarity) A6F68_02002 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A6F68_02004 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A6F68_02006 ENOG4105EQH reductase A6F68_02009 ENOG4105BZU Histidine kinase A6F68_02010 ENOG4105BZU Histidine kinase A6F68_02011 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A6F68_02018 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A6F68_02020 ENOG4108M3R transcriptional activator CadC A6F68_02021 ENOG4105BZU Histidine kinase A6F68_02022 ENOG4108JA2 transcriptioN-repair coupling factor A6F68_02024 ENOG4105DY8 decarboxylase A6F68_02025 ENOG4105CB5 ATP-dependent DNA helicase recG A6F68_02029 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A6F68_02030 ENOG4107R0V Pyruvate dehydrogenase A6F68_02031 ENOG4105CPP Dehydrogenase, E1 component A6F68_02032 ENOG4107QSN dihydrolipoamide acetyltransferase A6F68_02036 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A6F68_02040 ENOG4105CV1 Transketolase (EC 2.2.1.1) A6F68_02044 ENOG4105WYW fructose-bisphosphate aldolase A6F68_02046 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A6F68_02047 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein A6F68_02048 ENOG4108K5P (LipO)protein A6F68_02050 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A6F68_02051 ENOG4105ECY inositol monophosphatase A6F68_02056 ENOG4107RET Isocitrate lyase A6F68_02061 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A6F68_02063 ENOG4105DHU Bile acid A6F68_02065 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) A6F68_02066 ENOG4105CUB amino acid A6F68_02069 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA A6F68_02074 ENOG4105C0B DNA polymerase III (alpha subunit) A6F68_02076 ENOG410829K Lysine exporter protein (Lyse ygga) A6F68_02079 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6F68_02081 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A6F68_02083 ENOG4105C8U phosphate abc transporter A6F68_02084 ENOG4105BZU Histidine kinase A6F68_02087 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A6F68_02093 ENOG4105D9U N-acetyltransferase A6F68_02094 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) A6F68_02096 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A6F68_02097 ENOG4108ZP8 Acetolactate synthase small subunit A6F68_02098 ENOG4105C7K acetolactate synthase A6F68_02099 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A6F68_02104 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii A6F68_02108 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A6F68_02109 ENOG4105CTB Polyprenyl synthetase A6F68_02110 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) A6F68_02111 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A6F68_02112 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A6F68_02113 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) A6F68_02115 ENOG4105DA5 (ABC) transporter A6F68_02116 ENOG4105E3A (ABC) transporter A6F68_02118 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A6F68_02121 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A6F68_02125 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) A6F68_02127 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A6F68_02128 ENOG4108YZG isomerase A6F68_02129 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6F68_02130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A6F68_02136 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A6F68_02142 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A6F68_02148 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A6F68_02150 ENOG4105CVE Lytic murein transglycosylase A6F68_02153 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A6F68_02154 ENOG4107QRG dna polymerase iii A6F68_02156 ENOG4105F8V Hydrolase, tatD family A6F68_02157 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A6F68_02159 ENOG4105DXN mazG family A6F68_02160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A6F68_02161 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A6F68_02162 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A6F68_02163 ENOG4105ES5 Histidine kinase A6F68_02165 ENOG4105CUX Signal transduction histidine kinase A6F68_02167 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A6F68_02169 ENOG4107TH8 cina domain protein A6F68_02170 ENOG4108Z1B Cyclase dehydrase A6F68_02171 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A6F68_02174 ENOG41077A9 carbonic anhydrase A6F68_02180 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) A6F68_02200 ENOG4105VW4 glutaredoxin 3 A6F68_02201 ENOG4108ZNX Heat shock protein A6F68_02202 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A6F68_02204 ENOG4105CP7 Triose-phosphate isomerase A6F68_02206 ENOG4105CRQ synthase (Component I) A6F68_02209 ENOG4105DDQ anthranilate synthase A6F68_02210 ENOG4108I0Q anthranilate phosphoribosyltransferase A6F68_02211 ENOG4105DK0 Indole-3-glycerol phosphate synthase A6F68_02212 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A6F68_02213 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 A6F68_02214 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A6F68_02215 ENOG4105BZN citrate synthase A6F68_02217 ENOG4105BZU Histidine kinase A6F68_02224 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) A6F68_02225 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A6F68_02226 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6F68_02227 ENOG4105C8S subunit m A6F68_02228 ENOG4105D65 subunit l A6F68_02229 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6F68_02230 ENOG4105DF2 NADH dehydrogenase subunit j A6F68_02231 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6F68_02232 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) A6F68_02233 ENOG4107R0R NADH dehydrogenase subunit g A6F68_02238 ENOG4107QIZ NADH dehydrogenase A6F68_02242 ENOG41082W1 Cupin 2, conserved barrel domain protein A6F68_02243 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6F68_02245 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A6F68_02246 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6F68_02247 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A6F68_02249 ENOG4107RGH Aldehyde dehydrogenase A6F68_02250 ENOG4105CHU acetyl-coa acetyltransferase A6F68_02258 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A6F68_02259 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A6F68_02260 ENOG4108JQC penicillin-binding protein 1A A6F68_02261 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A6F68_02263 ENOG4105C03 ribonuclease A6F68_02264 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A6F68_02266 ENOG4108S55 polysaccharide biosynthesis protein A6F68_02271 ENOG4105D6Z AFG1 family ATPase A6F68_02272 ENOG4105C2I pirin domain protein A6F68_02273 ENOG4105CAQ asparagine synthetase A6F68_02284 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_02286 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A6F68_02290 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A6F68_02292 ENOG4105C01 Dihydroxy-acid dehydratase A6F68_02294 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A6F68_02295 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase A6F68_02298 ENOG4108RIR Molybdenum cofactor biosynthesis protein A6F68_02304 ENOG4105CSU acyl-Coa dehydrogenase A6F68_02305 ENOG4108Z6Z Transcriptional regulator A6F68_02306 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A6F68_02309 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A6F68_02310 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A6F68_02311 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit A6F68_02313 ENOG4105VZ8 Transcriptional regulator A6F68_02317 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) A6F68_02318 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A6F68_02319 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A6F68_02322 ENOG4105CHR reductase A6F68_02323 ENOG4105CJW magnesium transporter A6F68_02324 ENOG4105C3G gtp-binding protein A6F68_02325 ENOG4108TM9 integral membrane protein A6F68_02326 ENOG4105DXM phenylacetic acid degradation protein A6F68_02328 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A6F68_02333 ENOG4105CNI cell division protein FtsW A6F68_02336 ENOG4105D2B acyl-CoA dehydrogenase A6F68_02337 ENOG4105E39 Enoyl-CoA hydratase A6F68_02338 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F A6F68_02347 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A6F68_02348 ENOG4105DGW oligopeptidase A A6F68_02349 ENOG4105IIU Aminopeptidase A6F68_02351 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) A6F68_02353 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A6F68_02354 ENOG4105CSH Transporter A6F68_02359 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A6F68_02360 ENOG4105KJF protein tyrosine phosphatase A6F68_02362 ENOG4105CFG Acts as a chaperone (By similarity) A6F68_02368 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) A6F68_02369 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A6F68_02370 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A6F68_02371 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A6F68_02372 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A6F68_02374 ENOG4105CSA Coproporphyrinogen iii oxidase A6F68_02375 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A6F68_02376 ENOG4107T5V SNARE associated Golgi A6F68_02377 ENOG4105FYV Amp nucleosidase A6F68_02385 ENOG4105J12 Multidrug resistance protein mdtN A6F68_02386 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6F68_02388 ENOG4108R96 Methyltransferase, YaeB family A6F68_02390 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A6F68_02391 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A6F68_02392 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A6F68_02393 ENOG4105C3M thioredoxin reductase A6F68_02394 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A6F68_02395 ENOG4105K5M 30s ribosomal protein S16 A6F68_02396 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY A6F68_02399 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A6F68_02401 ENOG4105CAT Cytidine monophosphate kinase A6F68_02402 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A6F68_02403 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A6F68_02405 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A6F68_02408 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A6F68_02409 ENOG4105VD1 ATP synthase subunit C A6F68_02410 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) A6F68_02412 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A6F68_02417 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A6F68_02418 ENOG4105C6Y Udp-glucose 6-dehydrogenase A6F68_02421 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase A6F68_02427 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase A6F68_02428 ENOG4105PGM cation diffusion facilitator family transporter A6F68_02430 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A6F68_02431 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A6F68_02432 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A6F68_02434 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A6F68_02439 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A6F68_02440 ENOG4108UQY Iron-storage protein A6F68_02442 ENOG4105DHF Membrane A6F68_02444 ENOG4107QJE Chromosome Partitioning Protein A6F68_02449 ENOG4105CD3 dihydroorotase A6F68_02450 ENOG4105CXT aspartate transcarbamylase A6F68_02451 ENOG4105D07 Signal peptide peptidase, SppA A6F68_02455 ENOG4107S1E Beta-lactamase A6F68_02456 ENOG4105RQF LysR family Transcriptional regulator A6F68_02458 ENOG4107S8C mandelate racemase muconate lactonizing A6F68_02466 ENOG4105C42 Type I secretion membrane fusion protein (HlyD A6F68_02468 ENOG4108JJA ABC, transporter A6F68_02469 ENOG4105DFG type I secretion outer membrane protein A6F68_02470 ENOG4105UYK outer membrane protein a A6F68_02474 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A6F68_02475 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) A6F68_02478 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) A6F68_02482 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A6F68_02483 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A6F68_02484 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A6F68_02486 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A6F68_02488 ENOG4105C1G acyl-Coa dehydrogenase A6F68_02489 ENOG4108RXX maleylacetoacetate isomerase A6F68_02491 ENOG4105CHR reductase A6F68_02492 ENOG4105CC9 acyl-Coa dehydrogenase A6F68_02494 ENOG4105CC9 acyl-Coa dehydrogenase A6F68_02495 ENOG4105C1G acyl-Coa dehydrogenase A6F68_02498 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) A6F68_02499 ENOG4105CEY Amp-dependent synthetase and ligase A6F68_02501 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A6F68_02503 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A6F68_02504 ENOG4105E5G Alpha beta hydrolase fold A6F68_02507 ENOG4105E6M Sulphatase-modifying factor protein A6F68_02508 ENOG4108ESZ Glycogen debranching enzyme A6F68_02509 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 A6F68_02510 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A6F68_02511 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A6F68_02512 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) A6F68_02513 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) A6F68_02514 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) A6F68_02515 ENOG4105C11 sulfate adenylyltransferase), subunit 2 A6F68_02517 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo A6F68_02524 ENOG4105EUZ Beta-lactamase domain protein A6F68_02525 ENOG4105HHA aminodeoxychorismate lyase A6F68_02526 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A6F68_02527 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A6F68_02530 ENOG4105C9M aspartyl-trna synthetase A6F68_02531 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) A6F68_02534 ENOG4105C5Q Transcriptional regulator A6F68_02540 ENOG4105BZU Histidine kinase A6F68_02541 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A6F68_02542 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A6F68_02543 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A6F68_02544 ENOG4107835 probably involved in intracellular septation (By similarity) A6F68_02547 ENOG4105DFH Transport of potassium into the cell (By similarity) A6F68_02549 ENOG4105KWW Biogenesis protein A6F68_02550 ENOG4107QX9 Thiol disulfide interChange protein A6F68_02551 ENOG4105DA4 cytochrome c-type biogenesis protein A6F68_02552 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) A6F68_02554 ENOG41060IM Heme exporter protein A6F68_02559 ENOG41082FS 50S ribosomal protein L31 A6F68_02560 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A6F68_02562 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A6F68_02563 ENOG4105DZP Membrane-associated zinc metalloprotease A6F68_02565 ENOG4105KNE Phosphatidate cytidylyltransferase A6F68_02566 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A6F68_02567 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A6F68_02568 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A6F68_02571 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A6F68_02572 ENOG4105CE9 30S ribosomal protein S2 A6F68_02575 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme A6F68_02580 ENOG4105QPS Monooxygenase A6F68_02582 ENOG4105C26 Dehydrogenase A6F68_02586 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein A6F68_02588 ENOG4105D05 Receptor A6F68_02589 ENOG4105DS1 cytochrome b561 A6F68_02595 ENOG4105E39 Enoyl-CoA hydratase A6F68_02597 ENOG41076PI Short-chain dehydrogenase reductase Sdr A6F68_02599 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A6F68_02602 ENOG4108X79 transcriptional regulator A6F68_02604 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F A6F68_02605 ENOG4105C1G acyl-Coa dehydrogenase A6F68_02609 ENOG4105D05 Receptor A6F68_02611 ENOG4108ESX Receptor A6F68_02621 ENOG4105C26 Dehydrogenase A6F68_02624 ENOG4108UAU isochorismatase A6F68_02627 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A6F68_02628 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A6F68_02629 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A6F68_02634 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) A6F68_02639 ENOG41088PD hydrolase A6F68_02643 ENOG4105CHR reductase A6F68_02646 ENOG4106CY5 excisionase A6F68_02650 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_02651 ENOG4105DHQ Histidine kinase A6F68_02657 ENOG4107RH8 nuclease SbcCD subunit D A6F68_02663 ENOG4105C2N RNA methyltransferase TrmH family group 3 A6F68_02666 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A6F68_02668 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A6F68_02669 ENOG4107QMP dna polymerase iii subunits gamma and tau A6F68_02671 ENOG4105CQ7 ATP-dependent helicase A6F68_02672 ENOG4105EAH synthase A6F68_02673 ENOG4105EHE chorismate mutase- prephenate dehydrogenase A6F68_02674 ENOG4105IFJ Histidine kinase A6F68_02675 ENOG4105XJC Two component transcriptional regulator (Winged helix family A6F68_02678 ENOG4105C5H ABC transporter A6F68_02683 ENOG4105JNK Glycosyl transferase (Group 1 A6F68_02684 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A6F68_02685 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A6F68_02690 ENOG4108XM1 transcriptional regulator AsnC family A6F68_02691 ENOG4105ETE Transcriptional regulator (LacI family A6F68_02695 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A6F68_02696 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein A6F68_02697 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A6F68_02698 ENOG4105CEU Arginine dihydrolase A6F68_02701 ENOG4105F7P transcriptional regulator AsnC family A6F68_02702 ENOG4105BZU Histidine kinase A6F68_02707 ENOG4108JJ6 Type I secretion system ATPase A6F68_02708 ENOG4107QZV Type I secretion membrane fusion protein A6F68_02709 ENOG4105C5H ABC transporter A6F68_02715 ENOG4105DDW LysR family Transcriptional regulator A6F68_02716 ENOG4108NNI Beta-lactamase domain-containing protein A6F68_02723 ENOG4107EFR Flavocytochrome c A6F68_02727 ENOG4105C5H ABC transporter A6F68_02730 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A6F68_02737 ENOG4105DK7 lysyl-tRNA synthetase A6F68_02739 ENOG4105DVT helicase A6F68_02740 ENOG4105M4E phosphohistidine phosphatase, SixA A6F68_02741 ENOG4108Z4X TRANSCRIPTIONal A6F68_02744 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) A6F68_02750 ENOG4105CG5 Glycosyl transferase (Group 1 A6F68_02751 ENOG4105CNG UPF0061 protein A6F68_02754 ENOG4105C26 Dehydrogenase A6F68_02757 ENOG4105FR1 rard protein A6F68_02758 ENOG4105EKE dihydroorotase A6F68_02759 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) A6F68_02767 ENOG4108UPT UPF0178 protein A6F68_02775 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) A6F68_02778 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) A6F68_02779 ENOG4107R5W Monooxygenase A6F68_02780 ENOG4108UXN response regulator A6F68_02781 ENOG4105BZU Histidine kinase A6F68_02786 ENOG4108URH decarboxylase A6F68_02789 ENOG4107QX3 carboxylase A6F68_02790 ENOG4105C2C drug resistance transporter, Bcr CflA A6F68_02793 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A6F68_02799 ENOG4105WH1 Two component transcriptional regulator luxr family A6F68_02807 ENOG4105CGU Enoyl-CoA hydratase A6F68_02808 ENOG4105E39 Enoyl-CoA hydratase A6F68_02811 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A6F68_02812 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) A6F68_02813 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A6F68_02814 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) A6F68_02815 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A6F68_02816 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) A6F68_02818 ENOG4105C75 arginyL-tRNA synthetase A6F68_02820 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A6F68_02821 ENOG4105CUV Homoserine Kinase A6F68_02822 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A6F68_02823 ENOG4106YAV Domain of unknown function (DUF1508) A6F68_02824 ENOG4105FC8 fad dependent oxidoreductase A6F68_02834 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) A6F68_02835 ENOG4105CGU Enoyl-CoA hydratase A6F68_02838 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_02840 ENOG4105QV4 Tryptophan halogenase A6F68_02841 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A6F68_02844 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A6F68_02846 ENOG4105C1V Peptidase, M16 A6F68_02850 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A6F68_02851 ENOG4105CBX hi0933 family A6F68_02853 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) A6F68_02856 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) A6F68_02857 ENOG4108Z03 MAF-like protein A6F68_02861 ENOG4105EEQ Na H antiporter A6F68_02862 ENOG4107QPR SAICAR synthetase A6F68_02864 ENOG4107RAN Peptidase, M16 A6F68_02866 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A6F68_02867 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I A6F68_02879 ENOG4105DJP Membrane A6F68_02882 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A6F68_02883 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A6F68_02884 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A6F68_02885 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A6F68_02887 ENOG4105C3R Methionine synthase A6F68_02888 ENOG4105C3R Methionine synthase A6F68_02889 ENOG4105SYT Methylenetetrahydrofolate reductase A6F68_02890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A6F68_02891 ENOG4105F8J Adenylate Guanylate cyclase A6F68_02892 ENOG4108JQ7 (ABC) transporter A6F68_02894 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A6F68_02895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A6F68_02896 ENOG4107QSI ABC, transporter A6F68_02899 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A6F68_02902 ENOG4105QV4 Tryptophan halogenase A6F68_02904 ENOG4105ETE Transcriptional regulator (LacI family A6F68_02908 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A6F68_02914 ENOG4105EZE Cupin 4 family protein A6F68_02915 ENOG4108R99 pseudouridine synthase A6F68_02917 ENOG4105C5H ABC transporter A6F68_02926 ENOG4108JJ7 ABC transporter A6F68_02931 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A6F68_02936 ENOG4108UUM single-stranded DNA-binding protein A6F68_02937 ENOG4105CE1 Ferrous iron transport protein b A6F68_02941 ENOG4108ZX6 Electron transport protein SCO1 SenC A6F68_02942 ENOG4108ZZ3 UPF0260 protein A6F68_02945 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A6F68_02947 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A6F68_02948 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A6F68_02950 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) A6F68_02952 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)