locus-tag	class	description
A6F68_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F68_00003	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F68_00004	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6F68_00005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F68_00006	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F68_00007	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F68_00009	COG1301	dicarboxylic acid transport
A6F68_00010	COG1301	dicarboxylic acid transport
A6F68_00011	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F68_00013	COG0625	glutathione transferase activity
A6F68_00015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6F68_00016	COG0706	membrane insertase activity
A6F68_00017	COG0594	ribonuclease P activity
A6F68_00018	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F68_00027	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6F68_00030	COG2866	Carboxypeptidase
A6F68_00033	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6F68_00034	COG0295	cytidine deaminase activity
A6F68_00036	COG5328	Belongs to the UPF0262 family
A6F68_00037	COG0305	Participates in initiation and elongation during chromosome replication
A6F68_00039	COG1758	RNA polymerase activity
A6F68_00042	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6F68_00052	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6F68_00055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6F68_00060	COG1482	cell wall glycoprotein biosynthetic process
A6F68_00065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F68_00070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F68_00071	COG0667	Aldo Keto reductase
A6F68_00073	COG1501	Belongs to the glycosyl hydrolase 31 family
A6F68_00074	COG4771	TonB-dependent receptor
A6F68_00077	COG2855	membrane
A6F68_00078	COG4206	TonB-dependent receptor
A6F68_00079	COG2755	lipolytic protein G-D-S-L family
A6F68_00079	COG0657	acetylesterase activity
A6F68_00080	COG1301	dicarboxylic acid transport
A6F68_00081	COG4191	Histidine kinase
A6F68_00082	COG2204	response regulator
A6F68_00084	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F68_00085	COG0303	'Molybdopterin
A6F68_00086	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F68_00093	COG4774	siderophore transport
A6F68_00094	COG3119	arylsulfatase activity
A6F68_00096	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F68_00097	COG2423	ornithine cyclodeaminase activity
A6F68_00099	COG3119	arylsulfatase activity
A6F68_00102	COG0583	DNA-binding transcription factor activity
A6F68_00103	COG3386	PFAM SMP-30 Gluconolaconase
A6F68_00108	COG0129	dihydroxy-acid dehydratase activity
A6F68_00110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_00111	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_00112	COG3842	ATPase activity
A6F68_00113	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6F68_00114	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_00117	COG3246	L-lysine catabolic process to acetate
A6F68_00119	COG0583	DNA-binding transcription factor activity
A6F68_00120	COG4774	siderophore transport
A6F68_00121	COG2130	NADP-dependent
A6F68_00129	COG0582	viral genome integration into host DNA
A6F68_00138	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6F68_00144	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F68_00144	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F68_00147	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F68_00152	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F68_00154	COG0489	protein tyrosine kinase activity
A6F68_00156	COG0330	HflC and HflK could
A6F68_00157	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6F68_00160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F68_00161	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F68_00170	COG1228	amidohydrolase
A6F68_00171	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F68_00172	COG0085	RNA polymerase activity
A6F68_00175	COG3655	Transcriptional regulator
A6F68_00177	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F68_00178	COG0222	ribosome binding
A6F68_00181	COG3474	cytochrome
A6F68_00183	COG0534	Mate efflux family protein
A6F68_00184	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6F68_00185	COG0459	protein refolding
A6F68_00189	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F68_00189	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F68_00190	COG3920	Histidine kinase
A6F68_00192	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F68_00197	COG2070	2-Nitropropane dioxygenase
A6F68_00199	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6F68_00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F68_00202	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F68_00203	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6F68_00204	COG0124	histidyl-tRNA synthetase
A6F68_00206	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F68_00208	COG0312	modulator of DNA gyrase
A6F68_00210	COG1137	ATPase activity
A6F68_00211	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F68_00212	COG0745	RESPONSE REGULATOR receiver
A6F68_00213	COG0730	response to heat
A6F68_00214	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F68_00219	COG0280	phosphate acetyltransferase
A6F68_00219	COG0281	malic enzyme
A6F68_00220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F68_00224	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F68_00225	COG2096	Adenosyltransferase
A6F68_00227	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F68_00230	COG3483	tryptophan 2,3-dioxygenase activity
A6F68_00232	COG0747	negative chemotaxis
A6F68_00234	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F68_00244	COG0156	8-amino-7-oxononanoate synthase activity
A6F68_00245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6F68_00252	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F68_00254	COG0640	Transcriptional regulator
A6F68_00255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F68_00257	COG1238	metal cluster binding
A6F68_00261	COG4695	Portal protein
A6F68_00277	COG2885	chlorophyll binding
A6F68_00278	COG2032	superoxide dismutase activity
A6F68_00280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6F68_00282	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F68_00283	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F68_00284	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F68_00285	COG1278	Cold shock
A6F68_00286	COG1253	flavin adenine dinucleotide binding
A6F68_00288	COG1473	amidohydrolase
A6F68_00293	COG0004	ammonium transporteR
A6F68_00294	COG0347	Belongs to the P(II) protein family
A6F68_00297	COG0433	COG0433 Predicted ATPase
A6F68_00299	COG0564	pseudouridine synthase activity
A6F68_00301	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6F68_00305	COG0456	acetyltransferase
A6F68_00306	COG0688	phosphatidylethanolamine metabolic process
A6F68_00310	COG1073	alpha beta
A6F68_00314	COG0861	Integral membrane protein TerC family
A6F68_00316	COG0514	ATP-dependent DNA helicase (RecQ)
A6F68_00320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_00321	COG0183	Belongs to the thiolase family
A6F68_00322	COG3186	Phenylalanine-4-hydroxylase
A6F68_00325	COG1968	undecaprenyl-diphosphatase activity
A6F68_00326	COG1132	(ABC) transporter
A6F68_00329	COG0183	Belongs to the thiolase family
A6F68_00333	COG0438	transferase activity, transferring glycosyl groups
A6F68_00335	COG0069	glutamate synthase activity
A6F68_00335	COG0067	glutamate synthase
A6F68_00335	COG0070	glutamate synthase
A6F68_00339	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6F68_00346	COG0495	leucyl-tRNA aminoacylation
A6F68_00349	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_00354	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F68_00355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6F68_00356	COG1002	Type II restriction enzyme, methylase subunits
A6F68_00358	COG0739	heme binding
A6F68_00359	COG2833	Protein of unknown function (DUF455)
A6F68_00360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F68_00361	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6F68_00363	COG2957	Belongs to the agmatine deiminase family
A6F68_00366	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6F68_00371	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6F68_00374	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F68_00375	COG4152	abc transporter atp-binding protein
A6F68_00378	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F68_00382	COG0482	sulfurtransferase activity
A6F68_00387	COG0259	pyridoxamine-phosphate oxidase activity
A6F68_00388	COG0484	heat shock protein binding
A6F68_00389	COG1295	ribonuclease BN
A6F68_00390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F68_00393	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F68_00397	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6F68_00398	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A6F68_00399	COG1088	dTDP-glucose 4,6-dehydratase activity
A6F68_00404	COG1086	Polysaccharide biosynthesis protein
A6F68_00405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F68_00410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F68_00414	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6F68_00416	COG2089	acid synthase
A6F68_00418	COG1083	cytidylyl-transferase
A6F68_00423	COG1045	serine acetyltransferase
A6F68_00424	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6F68_00425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F68_00429	COG0793	Belongs to the peptidase S41A family
A6F68_00431	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F68_00432	COG0799	negative regulation of ribosome biogenesis
A6F68_00433	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F68_00434	COG0667	Aldo Keto reductase
A6F68_00435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F68_00436	COG0739	heme binding
A6F68_00439	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_00446	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6F68_00446	COG1793	dna ligase
A6F68_00448	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6F68_00450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F68_00453	COG0113	porphobilinogen synthase activity
A6F68_00454	COG0739	heme binding
A6F68_00458	COG1329	Transcriptional regulator
A6F68_00461	COG0009	L-threonylcarbamoyladenylate synthase
A6F68_00462	COG1960	acyl-CoA dehydrogenase activity
A6F68_00465	COG1956	GAF domain-containing protein
A6F68_00471	COG1475	DNA binding
A6F68_00472	COG1192	Involved in chromosome partitioning
A6F68_00473	COG0357	Ribosomal RNA small subunit methyltransferase G
A6F68_00474	COG0445	tRNA wobble uridine modification
A6F68_00475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F68_00481	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F68_00483	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6F68_00484	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6F68_00485	COG0424	maF-like protein
A6F68_00486	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6F68_00487	COG0237	dephospho-CoA kinase activity
A6F68_00488	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F68_00489	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6F68_00490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F68_00494	COG0316	Belongs to the HesB IscA family
A6F68_00502	COG3275	phosphorelay sensor kinase activity
A6F68_00508	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F68_00509	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6F68_00511	COG1612	heme a metabolic process
A6F68_00513	COG2022	thiamine diphosphate biosynthetic process
A6F68_00519	COG0405	Gamma-glutamyltransferase
A6F68_00520	COG0167	dihydroorotate dehydrogenase activity
A6F68_00523	COG0719	Fe-S assembly protein
A6F68_00527	COG0396	ATPase activity
A6F68_00529	COG0719	Fe-S assembly protein
A6F68_00530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6F68_00531	COG2151	metal-sulfur cluster biosynthetic enzyme
A6F68_00532	COG0316	Belongs to the HesB IscA family
A6F68_00536	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F68_00538	COG0151	Belongs to the GarS family
A6F68_00539	COG1570	exodeoxyribonuclease VII activity
A6F68_00542	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6F68_00543	COG0590	tRNA wobble adenosine to inosine editing
A6F68_00547	COG3279	Response regulator of the LytR AlgR family
A6F68_00548	COG3275	phosphorelay sensor kinase activity
A6F68_00552	COG0501	Belongs to the peptidase M48B family
A6F68_00561	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F68_00569	COG0745	RESPONSE REGULATOR receiver
A6F68_00570	COG2205	protein histidine kinase activity
A6F68_00572	COG4221	oxidoreductase activity
A6F68_00574	COG0072	phenylalanine-tRNA ligase activity
A6F68_00575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6F68_00580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6F68_00581	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6F68_00590	COG1494	fructose-1,6-bisphosphatase
A6F68_00601	COG1201	RNA secondary structure unwinding
A6F68_00607	COG1192	Involved in chromosome partitioning
A6F68_00608	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6F68_00610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F68_00615	COG0308	aminopeptidase N
A6F68_00624	COG0588	phosphoglycerate mutase activity
A6F68_00626	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F68_00628	COG0196	riboflavin kinase activity
A6F68_00629	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F68_00630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6F68_00632	COG1253	flavin adenine dinucleotide binding
A6F68_00634	COG0483	inositol monophosphate 1-phosphatase activity
A6F68_00635	COG0045	succinate-CoA ligase (ADP-forming) activity
A6F68_00636	COG2086	electron transfer activity
A6F68_00640	COG2733	membrane
A6F68_00642	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F68_00645	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A6F68_00649	COG2188	Transcriptional regulator
A6F68_00650	COG3104	oligopeptide transport
A6F68_00651	COG1228	amidohydrolase
A6F68_00654	COG2853	Lipoprotein
A6F68_00656	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6F68_00659	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F68_00663	COG0138	bifunctional purine biosynthesis protein purh
A6F68_00670	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_00671	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F68_00671	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F68_00671	COG0506	proline dehydrogenase activity
A6F68_00672	COG1309	transcriptional regulator
A6F68_00673	COG4774	siderophore transport
A6F68_00674	COG0717	Belongs to the dCTP deaminase family
A6F68_00675	COG3268	Saccharopine dehydrogenase
A6F68_00679	COG3118	belongs to the thioredoxin family
A6F68_00681	COG2095	MarC family integral membrane protein
A6F68_00683	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F68_00685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F68_00692	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F68_00692	COG1372	Participates in initiation and elongation during chromosome replication
A6F68_00694	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F68_00694	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F68_00701	COG2226	methyltransferase
A6F68_00702	COG1131	(ABC) transporter
A6F68_00704	COG0312	modulator of DNA gyrase
A6F68_00710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F68_00712	COG0572	uridine kinase
A6F68_00714	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F68_00714	COG0519	Catalyzes the synthesis of GMP from XMP
A6F68_00717	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_00720	COG0187	DNA topoisomerase II activity
A6F68_00726	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F68_00728	COG1960	acyl-CoA dehydrogenase activity
A6F68_00729	COG3920	Histidine kinase
A6F68_00730	COG1125	glycine betaine transport
A6F68_00731	COG1174	glycine betaine transport
A6F68_00734	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F68_00735	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_00736	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6F68_00738	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F68_00739	COG0352	thiamine-phosphate diphosphorylase activity
A6F68_00743	COG3746	phosphate-selective porin O and P
A6F68_00744	COG0686	Belongs to the AlaDH PNT family
A6F68_00746	COG2884	Cell division ATP-binding protein ftsE
A6F68_00750	COG0287	Prephenate dehydrogenase
A6F68_00751	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F68_00752	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F68_00753	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F68_00753	COG2813	Specifically methylates the guanine in position
A6F68_00754	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F68_00754	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F68_00755	COG2186	Transcriptional regulator
A6F68_00756	COG3734	2-keto-3-deoxy-galactonokinase
A6F68_00757	COG0800	Aldolase
A6F68_00760	COG3386	PFAM SMP-30 Gluconolaconase
A6F68_00761	COG0469	pyruvate kinase activity
A6F68_00763	COG3750	Belongs to the UPF0335 family
A6F68_00765	COG0217	transcriptional regulatory protein
A6F68_00767	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6F68_00769	COG1393	Belongs to the ArsC family
A6F68_00770	COG3201	nicotinamide mononucleotide transporter
A6F68_00772	COG0584	glycerophosphoryl diester phosphodiesterase
A6F68_00773	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F68_00774	COG0527	aspartate kinase activity
A6F68_00775	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6F68_00776	COG2070	2-Nitropropane dioxygenase
A6F68_00782	COG0667	Aldo Keto reductase
A6F68_00784	COG0330	HflC and HflK could
A6F68_00788	COG0582	viral genome integration into host DNA
A6F68_00789	COG3395	kinase activity
A6F68_00790	COG0235	Class ii aldolase
A6F68_00792	COG0473	3-isopropylmalate dehydrogenase activity
A6F68_00795	COG2186	Transcriptional regulator
A6F68_00796	COG3734	2-keto-3-deoxy-galactonokinase
A6F68_00807	COG3119	arylsulfatase activity
A6F68_00808	COG3119	arylsulfatase activity
A6F68_00814	COG3119	arylsulfatase activity
A6F68_00815	COG3119	arylsulfatase activity
A6F68_00821	COG3119	arylsulfatase activity
A6F68_00830	COG2186	Transcriptional regulator
A6F68_00831	COG0129	dihydroxy-acid dehydratase activity
A6F68_00835	COG0129	dihydroxy-acid dehydratase activity
A6F68_00836	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_00837	COG2186	Transcriptional regulator
A6F68_00847	COG3119	arylsulfatase activity
A6F68_00851	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F68_00851	COG0519	Catalyzes the synthesis of GMP from XMP
A6F68_00853	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A6F68_00859	COG0739	heme binding
A6F68_00864	COG0631	protein serine/threonine phosphatase activity
A6F68_00868	COG3501	Rhs element vgr protein
A6F68_00887	COG1132	(ABC) transporter
A6F68_00889	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6F68_00894	COG4106	trans-aconitate 2-methyltransferase activity
A6F68_00901	COG0438	transferase activity, transferring glycosyl groups
A6F68_00909	COG0183	Belongs to the thiolase family
A6F68_00910	COG1024	Enoyl-CoA hydratase
A6F68_00911	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_00913	COG3263	regulation of cellular component size
A6F68_00915	COG1960	acyl-CoA dehydrogenase activity
A6F68_00916	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_00917	COG1285	pathogenesis
A6F68_00923	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_00927	COG4765	Protein conserved in bacteria
A6F68_00928	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6F68_00932	COG0250	Participates in transcription elongation, termination and antitermination
A6F68_00934	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F68_00935	COG0081	regulation of translation
A6F68_00938	COG1546	Belongs to the CinA family
A6F68_00938	COG1058	Belongs to the CinA family
A6F68_00939	COG2072	flavoprotein involved in K transport
A6F68_00942	COG5001	Diguanylate cyclase
A6F68_00943	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6F68_00944	COG2201	protein-glutamate methylesterase activity
A6F68_00945	COG0745	RESPONSE REGULATOR receiver
A6F68_00947	COG0643	Histidine kinase
A6F68_00947	COG2198	Histidine kinase
A6F68_00952	COG0235	Class ii aldolase
A6F68_00953	COG2080	2 iron, 2 sulfur cluster binding
A6F68_00954	COG4774	siderophore transport
A6F68_00955	COG1393	Belongs to the ArsC family
A6F68_00959	COG0321	lipoyl(octanoyl) transferase activity
A6F68_00961	COG1902	pentaerythritol trinitrate reductase activity
A6F68_00963	COG4325	translation initiation factor activity
A6F68_00964	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6F68_00967	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F68_00968	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6F68_00975	COG0037	tRNA processing
A6F68_00976	COG1376	ErfK ybiS ycfS ynhG family protein
A6F68_00979	COG2301	Belongs to the HpcH HpaI aldolase family
A6F68_00980	COG0432	Pfam Uncharacterised protein family UPF0047
A6F68_00981	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F68_00982	COG0129	dihydroxy-acid dehydratase activity
A6F68_00983	COG0837	glucose binding
A6F68_00984	COG0800	Aldolase
A6F68_00988	COG0745	RESPONSE REGULATOR receiver
A6F68_00992	COG1196	nuclear chromosome segregation
A6F68_00992	COG0741	lytic transglycosylase activity
A6F68_00992	COG0739	heme binding
A6F68_00995	COG3451	type IV secretory pathway VirB4
A6F68_00999	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A6F68_01003	COG0612	Peptidase, M16
A6F68_01006	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F68_01011	COG0066	3-isopropylmalate dehydratase activity
A6F68_01014	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F68_01015	COG0824	Thioesterase
A6F68_01019	COG2166	iron-sulfur cluster assembly
A6F68_01027	COG1842	Phage shock protein A
A6F68_01029	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F68_01031	COG0779	Required for maturation of 30S ribosomal subunits
A6F68_01034	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6F68_01036	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6F68_01037	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F68_01038	COG1435	thymidine kinase activity
A6F68_01039	COG1994	Peptidase M50
A6F68_01040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F68_01041	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6F68_01042	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F68_01043	COG0275	rRNA processing
A6F68_01048	COG0842	Transport permease protein
A6F68_01058	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_01069	COG2843	Capsule synthesis protein
A6F68_01071	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F68_01074	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6F68_01076	COG3246	L-lysine catabolic process to acetate
A6F68_01077	COG2267	carboxylic ester hydrolase activity
A6F68_01081	COG2159	amidohydrolase
A6F68_01084	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6F68_01086	COG3618	amidohydrolase
A6F68_01090	COG4957	zinc ion binding
A6F68_01097	COG2223	nitrite transmembrane transporter activity
A6F68_01100	COG2217	Heavy metal translocating P-type atpase
A6F68_01101	COG0789	Transcriptional regulator
A6F68_01102	COG2132	Multicopper oxidase
A6F68_01104	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F68_01105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F68_01111	COG2010	Cytochrome c
A6F68_01115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F68_01122	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F68_01125	COG0314	molybdopterin synthase activity
A6F68_01138	COG1448	Aminotransferase
A6F68_01143	COG0180	Tryptophanyl-tRNA synthetase
A6F68_01144	COG0728	peptidoglycan biosynthetic process
A6F68_01145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6F68_01146	COG4395	Tim44
A6F68_01153	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6F68_01155	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A6F68_01157	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6F68_01158	COG0632	four-way junction helicase activity
A6F68_01160	COG2255	four-way junction helicase activity
A6F68_01165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F68_01166	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6F68_01168	COG2989	Protein conserved in bacteria
A6F68_01172	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6F68_01178	COG2367	Beta-lactamase
A6F68_01179	COG0454	-acetyltransferase
A6F68_01185	COG0714	Associated with various cellular activities
A6F68_01188	COG0077	Prephenate dehydratase
A6F68_01189	COG3474	cytochrome
A6F68_01191	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F68_01195	COG0351	phosphomethylpyrimidine kinase
A6F68_01195	COG0352	thiamine-phosphate diphosphorylase activity
A6F68_01196	COG3813	Protein conserved in bacteria
A6F68_01197	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F68_01203	COG3920	Histidine kinase
A6F68_01204	COG0784	Response regulator, receiver
A6F68_01206	COG0784	Response regulator, receiver
A6F68_01207	COG0456	acetyltransferase
A6F68_01213	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6F68_01215	COG3657	addiction module killer protein
A6F68_01218	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6F68_01219	COG0436	Aminotransferase
A6F68_01223	COG2003	Belongs to the UPF0758 family
A6F68_01224	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F68_01229	COG0556	nucleotide-excision repair
A6F68_01231	COG2226	methyltransferase
A6F68_01231	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F68_01231	COG0596	Alpha beta hydrolase
A6F68_01232	COG2308	Evidence 4 Homologs of previously reported genes of
A6F68_01234	COG1305	Transglutaminase-like
A6F68_01236	COG4566	intracellular signal transduction
A6F68_01238	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F68_01244	COG3220	belongs to the UPF0276 family
A6F68_01247	COG4771	TonB-dependent receptor
A6F68_01248	COG3152	Membrane
A6F68_01251	COG4181	ATPase activity
A6F68_01253	COG1381	Involved in DNA repair and RecF pathway recombination
A6F68_01254	COG0473	3-isopropylmalate dehydrogenase activity
A6F68_01262	COG3920	Histidine kinase
A6F68_01263	COG2967	ApaG domain
A6F68_01273	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F68_01274	COG0049	tRNA binding
A6F68_01275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F68_01276	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6F68_01277	COG0051	transcription antitermination factor activity, RNA binding
A6F68_01278	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6F68_01279	COG0088	Forms part of the polypeptide exit tunnel
A6F68_01280	COG0089	rRNA binding
A6F68_01281	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6F68_01282	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F68_01283	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6F68_01284	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F68_01285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6F68_01286	COG0255	Belongs to the universal ribosomal protein uL29 family
A6F68_01287	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F68_01288	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6F68_01289	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6F68_01290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6F68_01291	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6F68_01292	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6F68_01293	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6F68_01294	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F68_01295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6F68_01296	COG1841	ribosomal large subunit assembly
A6F68_01297	COG0200	Binds to the 23S rRNA
A6F68_01298	COG0201	protein transport
A6F68_01299	COG0563	adenylate kinase activity
A6F68_01301	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6F68_01302	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6F68_01303	COG0202	RNA polymerase activity
A6F68_01304	COG0203	ribosomal protein L17
A6F68_01305	COG1505	serine-type exopeptidase activity
A6F68_01308	COG2860	membrane
A6F68_01312	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F68_01314	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F68_01315	COG0567	Dehydrogenase, E1 component
A6F68_01316	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6F68_01317	COG0039	L-malate dehydrogenase activity
A6F68_01319	COG5001	Diguanylate cyclase
A6F68_01322	COG4206	TonB-dependent receptor
A6F68_01324	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6F68_01325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F68_01326	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6F68_01327	COG3590	peptidase
A6F68_01331	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F68_01336	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F68_01337	COG0137	argininosuccinate synthase activity
A6F68_01339	COG0596	Alpha beta hydrolase
A6F68_01342	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F68_01343	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F68_01344	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F68_01345	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A6F68_01349	COG0384	phenazine biosynthesis protein PhzF
A6F68_01350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F68_01356	COG0741	lytic transglycosylase activity
A6F68_01357	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F68_01359	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6F68_01364	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F68_01366	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F68_01369	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F68_01371	COG1032	radical SAM domain protein
A6F68_01372	COG3153	acetyltransferase
A6F68_01372	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F68_01373	COG0538	isocitrate dehydrogenase activity
A6F68_01378	COG0277	FAD linked oxidase domain protein
A6F68_01382	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6F68_01383	COG0210	DNA helicase
A6F68_01385	COG0742	ribosomal rna small subunit methyltransferase
A6F68_01386	COG1187	pseudouridine synthase activity
A6F68_01388	COG2223	nitrite transmembrane transporter activity
A6F68_01389	COG0285	dihydrofolate synthase activity
A6F68_01390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6F68_01391	COG0159	tryptophan synthase activity
A6F68_01393	COG0133	tryptophan synthase activity
A6F68_01394	COG0135	phosphoribosylanthranilate isomerase activity
A6F68_01395	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F68_01397	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F68_01398	COG2003	Belongs to the UPF0758 family
A6F68_01404	COG0730	response to heat
A6F68_01409	COG1064	alcohol dehydrogenase
A6F68_01410	COG0525	valine-tRNA ligase activity
A6F68_01411	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F68_01412	COG1127	ABC transporter
A6F68_01418	COG0546	phosphoglycolate phosphatase activity
A6F68_01420	COG0564	pseudouridine synthase activity
A6F68_01421	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F68_01422	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6F68_01423	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F68_01424	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6F68_01425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F68_01426	COG0154	amidase activity
A6F68_01428	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F68_01432	COG3447	MASE1 domain protein
A6F68_01432	COG5001	Diguanylate cyclase
A6F68_01432	COG5002	protein histidine kinase activity
A6F68_01434	COG1946	Acyl-CoA thioesterase
A6F68_01437	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6F68_01438	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F68_01439	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F68_01440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F68_01441	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F68_01444	COG0596	Alpha beta hydrolase
A6F68_01445	COG0300	oxidoreductase activity
A6F68_01446	COG1741	Belongs to the pirin family
A6F68_01454	COG5507	3-demethylubiquinone-9 3-methyltransferase
A6F68_01455	COG1733	regulation of RNA biosynthetic process
A6F68_01459	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F68_01464	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6F68_01465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F68_01466	COG0729	surface antigen
A6F68_01472	COG1476	TRANSCRIPTIONal
A6F68_01474	COG0174	glutamine synthetase
A6F68_01475	COG0347	Belongs to the P(II) protein family
A6F68_01476	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6F68_01480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F68_01482	COG0024	Methionine aminopeptidase
A6F68_01484	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F68_01485	COG4133	protoheme IX ABC transporter activity
A6F68_01486	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6F68_01491	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6F68_01494	COG2001	Belongs to the MraZ family
A6F68_01495	COG0275	rRNA processing
A6F68_01498	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F68_01500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F68_01501	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F68_01503	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F68_01504	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F68_01505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F68_01506	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F68_01507	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F68_01508	COG0849	cell division
A6F68_01509	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6F68_01512	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F68_01513	COG0670	Belongs to the BI1 family
A6F68_01516	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6F68_01517	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F68_01521	COG0175	sulfate reduction
A6F68_01525	COG1648	precorrin-2 dehydrogenase activity
A6F68_01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F68_01526	COG0668	transmembrane transport
A6F68_01527	COG0626	cystathionine gamma-synthase activity
A6F68_01528	COG2897	thiosulfate sulfurtransferase activity
A6F68_01530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F68_01533	COG0114	fumarate hydratase activity
A6F68_01536	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F68_01537	COG1695	Transcriptional regulator
A6F68_01539	COG0438	transferase activity, transferring glycosyl groups
A6F68_01539	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F68_01540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6F68_01541	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F68_01542	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F68_01547	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6F68_01553	COG1648	precorrin-2 dehydrogenase activity
A6F68_01553	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F68_01554	COG0019	diaminopimelate decarboxylase activity
A6F68_01556	COG0165	Argininosuccinate lyase
A6F68_01557	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F68_01560	COG0252	asparaginase activity
A6F68_01562	COG0101	tRNA pseudouridine synthase activity
A6F68_01563	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6F68_01564	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F68_01565	COG0242	peptide deformylase activity
A6F68_01567	COG1322	Protein conserved in bacteria
A6F68_01569	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F68_01571	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F68_01571	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6F68_01572	COG1660	Displays ATPase and GTPase activities
A6F68_01573	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6F68_01574	COG0642	Histidine kinase
A6F68_01575	COG0745	RESPONSE REGULATOR receiver
A6F68_01576	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6F68_01582	COG2945	thiolester hydrolase activity
A6F68_01584	COG1104	cysteine desulfurase activity
A6F68_01588	COG0693	protein deglycase activity
A6F68_01589	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F68_01591	COG0617	tRNA 3'-terminal CCA addition
A6F68_01595	COG2133	pyrroloquinoline quinone binding
A6F68_01596	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6F68_01602	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01603	COG2204	response regulator
A6F68_01605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F68_01606	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F68_01607	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6F68_01609	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01613	COG2267	carboxylic ester hydrolase activity
A6F68_01615	COG1404	Belongs to the peptidase S8 family
A6F68_01616	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F68_01618	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6F68_01618	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6F68_01619	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F68_01622	COG0681	Belongs to the peptidase S26 family
A6F68_01623	COG0736	holo-[acyl-carrier-protein] synthase activity
A6F68_01624	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F68_01625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6F68_01627	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F68_01629	COG0109	protoheme IX farnesyltransferase activity
A6F68_01631	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F68_01641	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F68_01642	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6F68_01653	COG2171	N-acyltransferase activity
A6F68_01657	COG1960	acyl-CoA dehydrogenase activity
A6F68_01658	COG2211	Major facilitator Superfamily
A6F68_01659	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01660	COG1960	acyl-CoA dehydrogenase activity
A6F68_01661	COG1960	acyl-CoA dehydrogenase activity
A6F68_01662	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01663	COG2311	Membrane
A6F68_01665	COG1505	serine-type exopeptidase activity
A6F68_01668	COG0194	GDP metabolic process
A6F68_01671	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F68_01672	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F68_01673	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6F68_01674	COG0107	imidazoleglycerol-phosphate synthase activity
A6F68_01676	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F68_01678	COG0824	Thioesterase
A6F68_01682	COG0823	Involved in the tonB-independent uptake of proteins
A6F68_01683	COG2885	chlorophyll binding
A6F68_01685	COG0484	heat shock protein binding
A6F68_01689	COG0471	metal ion transport
A6F68_01691	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F68_01695	COG0408	coproporphyrinogen oxidase activity
A6F68_01696	COG2124	cytochrome p450
A6F68_01698	COG1294	oxidase, subunit
A6F68_01699	COG1271	oxidase subunit
A6F68_01702	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F68_01711	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01716	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6F68_01719	COG2186	Transcriptional regulator
A6F68_01722	COG2271	Major facilitator Superfamily
A6F68_01723	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01724	COG0183	Belongs to the thiolase family
A6F68_01725	COG0183	Belongs to the thiolase family
A6F68_01726	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_01731	COG1733	regulation of RNA biosynthetic process
A6F68_01736	COG0625	glutathione transferase activity
A6F68_01738	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F68_01738	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F68_01742	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F68_01744	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6F68_01745	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6F68_01748	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F68_01756	COG1970	mechanosensitive ion channel activity
A6F68_01759	COG3724	N-succinylarginine dihydrolase activity
A6F68_01762	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6F68_01765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F68_01766	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F68_01767	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F68_01768	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6F68_01769	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F68_01771	COG0105	UTP biosynthetic process
A6F68_01775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F68_01776	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6F68_01778	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F68_01779	COG1045	serine acetyltransferase
A6F68_01781	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01782	COG0546	phosphoglycolate phosphatase activity
A6F68_01783	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6F68_01787	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F68_01788	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6F68_01789	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6F68_01790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6F68_01791	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F68_01794	COG2169	Transcriptional regulator
A6F68_01794	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F68_01795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6F68_01802	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6F68_01805	COG0215	cysteine-tRNA ligase activity
A6F68_01806	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F68_01808	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_01813	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F68_01821	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6F68_01822	COG0416	fatty acid biosynthetic process
A6F68_01823	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F68_01824	COG0776	regulation of translation
A6F68_01830	COG1194	a g-specific adenine glycosylase
A6F68_01833	COG2816	NAD+ diphosphatase activity
A6F68_01836	COG2239	Acts as a magnesium transporter
A6F68_01837	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F68_01838	COG2217	Heavy metal translocating P-type atpase
A6F68_01839	COG0583	DNA-binding transcription factor activity
A6F68_01841	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6F68_01842	COG1702	phosphate starvation-inducible protein PhoH
A6F68_01844	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F68_01848	COG0454	-acetyltransferase
A6F68_01848	COG0456	acetyltransferase
A6F68_01849	COG1214	PFAM Peptidase M22, glycoprotease
A6F68_01850	COG0778	Nitroreductase
A6F68_01851	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6F68_01852	COG0612	Peptidase, M16
A6F68_01853	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F68_01855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F68_01856	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6F68_01859	COG0492	ferredoxin-NADP+ reductase activity
A6F68_01863	COG1748	Saccharopine dehydrogenase
A6F68_01867	COG2175	clavaminate synthase activity
A6F68_01869	COG5001	Diguanylate cyclase
A6F68_01869	COG3300	MHYT domain
A6F68_01870	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_01871	COG0156	8-amino-7-oxononanoate synthase activity
A6F68_01872	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6F68_01873	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F68_01874	COG0758	DNA mediated transformation
A6F68_01875	COG1754	DNA topoisomerase type I activity
A6F68_01875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F68_01877	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6F68_01878	COG0571	ribonuclease III activity
A6F68_01879	COG0681	Belongs to the peptidase S26 family
A6F68_01880	COG0166	Belongs to the GPI family
A6F68_01882	COG0513	Belongs to the DEAD box helicase family
A6F68_01885	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6F68_01886	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F68_01889	COG1024	Enoyl-CoA hydratase
A6F68_01893	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6F68_01897	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6F68_01898	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F68_01899	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6F68_01902	COG4974	Belongs to the 'phage' integrase family
A6F68_01903	COG0825	malonyl-CoA metabolic process
A6F68_01904	COG4783	chaperone-mediated protein folding
A6F68_01907	COG0494	nUDIX hydrolase
A6F68_01910	COG0302	gtp cyclohydrolase
A6F68_01912	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F68_01912	COG0678	peroxiredoxin activity
A6F68_01914	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F68_01915	COG2205	protein histidine kinase activity
A6F68_01916	COG0802	atpase or kinase
A6F68_01917	COG3178	'Phosphotransferase
A6F68_01918	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6F68_01920	COG1074	ATP-dependent DNA helicase activity
A6F68_01922	COG0483	inositol monophosphate 1-phosphatase activity
A6F68_01923	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6F68_01926	COG0653	protein targeting
A6F68_01930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F68_01935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F68_01938	COG2264	protein methyltransferase activity
A6F68_01940	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01942	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F68_01949	COG1304	FMN binding
A6F68_01953	COG2321	neutral zinc metallopeptidase
A6F68_01954	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_01957	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F68_01957	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F68_01959	COG1051	belongs to the nudix hydrolase family
A6F68_01961	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6F68_01961	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6F68_01962	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6F68_01965	COG0415	Belongs to the DNA photolyase family
A6F68_01966	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6F68_01968	COG4221	oxidoreductase activity
A6F68_01969	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F68_01970	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6F68_01971	COG1136	(ABC) transporter
A6F68_01973	COG0386	Belongs to the glutathione peroxidase family
A6F68_01974	COG0587	DNA-directed DNA polymerase activity
A6F68_01975	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_01981	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F68_01983	COG3876	Protein conserved in bacteria
A6F68_01984	COG2814	Major facilitator Superfamily
A6F68_01987	COG0840	transmembrane signaling receptor activity
A6F68_01989	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F68_01990	COG0187	DNA topoisomerase II activity
A6F68_01992	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F68_01993	COG0792	nuclease activity
A6F68_01994	COG0189	ligase activity
A6F68_01996	COG0359	binds to the 23S rRNA
A6F68_01997	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6F68_01998	COG0360	Binds together with S18 to 16S ribosomal RNA
A6F68_01999	COG2354	Protein conserved in bacteria
A6F68_02000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F68_02004	COG0592	DNA-directed DNA polymerase activity
A6F68_02006	COG0493	'glutamate synthase
A6F68_02009	COG3300	MHYT domain
A6F68_02009	COG5001	Diguanylate cyclase
A6F68_02010	COG3300	MHYT domain
A6F68_02010	COG5001	Diguanylate cyclase
A6F68_02011	COG0481	GTPase activity
A6F68_02018	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F68_02020	COG3710	Transcriptional regulator
A6F68_02022	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F68_02024	COG0076	glutamate decarboxylase activity
A6F68_02025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F68_02029	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F68_02036	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F68_02041	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6F68_02044	COG3588	fructose-bisphosphate aldolase
A6F68_02046	COG0352	thiamine-phosphate diphosphorylase activity
A6F68_02047	COG1376	ErfK ybiS ycfS ynhG family protein
A6F68_02048	COG4942	peptidase
A6F68_02050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F68_02051	COG0483	inositol monophosphate 1-phosphatase activity
A6F68_02053	COG0471	metal ion transport
A6F68_02053	COG3273	potassium ion transport
A6F68_02059	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F68_02061	COG2204	response regulator
A6F68_02063	COG0385	Bile acid
A6F68_02065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6F68_02066	COG0531	amino acid
A6F68_02069	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6F68_02071	COG2267	carboxylic ester hydrolase activity
A6F68_02074	COG0587	DNA-directed DNA polymerase activity
A6F68_02076	COG1280	lysine exporter protein (LysE YggA)
A6F68_02078	COG2119	membrane
A6F68_02079	COG0745	RESPONSE REGULATOR receiver
A6F68_02080	COG0704	Plays a role in the regulation of phosphate uptake
A6F68_02081	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F68_02083	COG0573	inorganic phosphate transmembrane transporter activity
A6F68_02084	COG5002	protein histidine kinase activity
A6F68_02087	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6F68_02092	COG3618	amidohydrolase
A6F68_02094	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F68_02096	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6F68_02098	COG0028	Belongs to the TPP enzyme family
A6F68_02099	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F68_02104	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F68_02108	COG1722	exodeoxyribonuclease VII activity
A6F68_02109	COG0142	geranyltranstransferase activity
A6F68_02110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6F68_02111	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F68_02112	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6F68_02113	COG1309	transcriptional regulator
A6F68_02114	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A6F68_02115	COG1131	(ABC) transporter
A6F68_02116	COG0842	Transport permease protein
A6F68_02118	COG0343	queuine tRNA-ribosyltransferase activity
A6F68_02121	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F68_02125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F68_02127	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F68_02128	COG0698	ribose 5-phosphate isomerase
A6F68_02129	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F68_02130	COG0358	DNA primase activity
A6F68_02133	COG0505	Belongs to the CarA family
A6F68_02136	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F68_02142	COG0148	phosphopyruvate hydratase activity
A6F68_02148	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F68_02150	COG2951	lytic endotransglycosylase activity
A6F68_02152	COG1686	Belongs to the peptidase S11 family
A6F68_02153	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6F68_02156	COG0084	hydrolase, TatD family'
A6F68_02157	COG0321	lipoyl(octanoyl) transferase activity
A6F68_02157	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6F68_02159	COG3956	TIGRFAM MazG family protein
A6F68_02160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F68_02162	COG2204	response regulator
A6F68_02163	COG5000	phosphorelay sensor kinase activity
A6F68_02165	COG3852	Histidine kinase
A6F68_02167	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6F68_02167	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6F68_02169	COG1546	Belongs to the CinA family
A6F68_02170	COG2867	negative regulation of translational initiation
A6F68_02171	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F68_02174	COG0288	reversible hydration of carbon dioxide
A6F68_02177	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F68_02180	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6F68_02189	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F68_02189	COG0022	dehydrogenase e1 component
A6F68_02190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F68_02199	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F68_02201	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F68_02202	COG0504	CTP synthase activity
A6F68_02203	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F68_02204	COG0149	triose-phosphate isomerase activity
A6F68_02206	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F68_02210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F68_02211	COG0134	indole-3-glycerol-phosphate synthase activity
A6F68_02212	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6F68_02213	COG0658	competence protein
A6F68_02213	COG2333	competence protein COMEC
A6F68_02214	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F68_02215	COG0372	Belongs to the citrate synthase family
A6F68_02217	COG2205	protein histidine kinase activity
A6F68_02224	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F68_02226	COG1007	ATP synthesis coupled electron transport
A6F68_02229	COG0713	ATP synthesis coupled electron transport
A6F68_02231	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F68_02232	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6F68_02238	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6F68_02241	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6F68_02242	COG0662	Cupin 2, conserved barrel domain protein
A6F68_02243	COG0649	NAD binding
A6F68_02245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F68_02246	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F68_02247	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F68_02249	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_02250	COG0183	Belongs to the thiolase family
A6F68_02259	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F68_02260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F68_02263	COG1530	ribonuclease E activity
A6F68_02264	COG2226	methyltransferase
A6F68_02266	COG2244	polysaccharide biosynthetic process
A6F68_02269	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6F68_02271	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F68_02273	COG0367	asparagine synthase
A6F68_02278	COG3409	Peptidoglycan-binding domain 1 protein
A6F68_02278	COG3267	Type II secretory pathway component ExeA
A6F68_02284	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_02286	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F68_02289	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F68_02290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6F68_02290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6F68_02292	COG0129	dihydroxy-acid dehydratase activity
A6F68_02294	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F68_02298	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F68_02304	COG1960	acyl-CoA dehydrogenase activity
A6F68_02305	COG0789	Transcriptional regulator
A6F68_02306	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F68_02309	COG0574	Belongs to the PEP-utilizing enzyme family
A6F68_02309	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F68_02310	COG0751	glycine-tRNA ligase activity
A6F68_02311	COG0752	glycyl-tRNA synthetase alpha subunit
A6F68_02313	COG1476	TRANSCRIPTIONal
A6F68_02317	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6F68_02318	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6F68_02319	COG0193	aminoacyl-tRNA hydrolase activity
A6F68_02322	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_02323	COG2239	Acts as a magnesium transporter
A6F68_02324	COG0012	GTP binding
A6F68_02326	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_02326	COG2030	dehydratase
A6F68_02328	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6F68_02333	COG0772	Belongs to the SEDS family
A6F68_02336	COG1960	acyl-CoA dehydrogenase activity
A6F68_02337	COG1024	Enoyl-CoA hydratase
A6F68_02338	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F68_02343	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F68_02347	COG0557	exoribonuclease II activity
A6F68_02348	COG0339	signal peptide processing
A6F68_02349	COG2234	aminopeptidase activity
A6F68_02351	COG0442	prolyl-tRNA aminoacylation
A6F68_02353	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6F68_02354	COG0477	Major facilitator Superfamily
A6F68_02358	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F68_02359	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F68_02360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F68_02361	COG0484	heat shock protein binding
A6F68_02362	COG0443	Heat shock 70 kDa protein
A6F68_02368	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6F68_02369	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F68_02370	COG1420	regulation of RNA biosynthetic process
A6F68_02371	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6F68_02372	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6F68_02374	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F68_02375	COG4974	Belongs to the 'phage' integrase family
A6F68_02376	COG0586	Pfam SNARE associated Golgi protein
A6F68_02377	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F68_02386	COG2814	Major facilitator Superfamily
A6F68_02390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6F68_02391	COG0335	large ribosomal subunit rRNA binding
A6F68_02392	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F68_02393	COG0492	ferredoxin-NADP+ reductase activity
A6F68_02394	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F68_02395	COG0228	four-way junction DNA binding
A6F68_02396	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F68_02399	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F68_02401	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F68_02402	COG0539	negative regulation of cytoplasmic translation
A6F68_02403	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F68_02408	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F68_02409	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F68_02410	COG0356	it plays a direct role in the translocation of protons across the membrane
A6F68_02412	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F68_02417	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F68_02418	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6F68_02421	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6F68_02424	COG0564	pseudouridine synthase activity
A6F68_02425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F68_02427	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F68_02430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F68_02431	COG0740	serine-type endopeptidase activity
A6F68_02432	COG0154	amidase activity
A6F68_02434	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F68_02439	COG1160	GTP binding
A6F68_02442	COG2311	Membrane
A6F68_02444	COG1192	Involved in chromosome partitioning
A6F68_02449	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6F68_02450	COG0540	Belongs to the ATCase OTCase family
A6F68_02451	COG0616	signal peptide processing
A6F68_02456	COG0583	DNA-binding transcription factor activity
A6F68_02458	COG4948	Mandelate Racemase Muconate Lactonizing
A6F68_02459	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6F68_02469	COG1538	Outer membrane efflux protein
A6F68_02470	COG2885	chlorophyll binding
A6F68_02470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F68_02474	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6F68_02475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F68_02478	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F68_02482	COG0181	hydroxymethylbilane synthase activity
A6F68_02483	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6F68_02484	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6F68_02486	COG3743	rRNA binding
A6F68_02486	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F68_02488	COG1960	acyl-CoA dehydrogenase activity
A6F68_02489	COG0625	glutathione transferase activity
A6F68_02491	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_02492	COG1960	acyl-CoA dehydrogenase activity
A6F68_02493	COG2211	Major facilitator Superfamily
A6F68_02494	COG1960	acyl-CoA dehydrogenase activity
A6F68_02498	COG1309	transcriptional regulator
A6F68_02499	COG0318	PFAM AMP-dependent synthetase and ligase
A6F68_02501	COG1024	Enoyl-CoA hydratase
A6F68_02501	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F68_02503	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F68_02504	COG2267	carboxylic ester hydrolase activity
A6F68_02506	COG0028	Belongs to the TPP enzyme family
A6F68_02507	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F68_02508	COG1523	belongs to the glycosyl hydrolase 13 family
A6F68_02509	COG0033	Phosphoglucomutase
A6F68_02510	COG0297	glycogen (starch) synthase activity
A6F68_02511	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6F68_02512	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6F68_02513	COG0058	SHG alpha-glucan phosphorylase activity
A6F68_02514	COG1640	4-alpha-glucanotransferase
A6F68_02515	COG0175	sulfate reduction
A6F68_02517	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6F68_02524	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A6F68_02525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F68_02526	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F68_02527	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F68_02530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F68_02531	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F68_02533	COG3668	Plasmid stabilization system
A6F68_02534	COG0583	DNA-binding transcription factor activity
A6F68_02537	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F68_02540	COG3300	MHYT domain
A6F68_02540	COG5001	Diguanylate cyclase
A6F68_02541	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F68_02542	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F68_02543	COG0552	protein localization to endoplasmic reticulum
A6F68_02544	COG2917	probably involved in intracellular septation
A6F68_02547	COG3158	transport of potassium into the cell
A6F68_02549	COG3088	subunit of a heme lyase
A6F68_02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F68_02551	COG1138	Cytochrome C-type biogenesis protein
A6F68_02552	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6F68_02554	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F68_02559	COG0254	rRNA binding
A6F68_02560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F68_02562	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F68_02563	COG0750	zinc metalloprotease
A6F68_02564	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F68_02565	COG0575	Belongs to the CDS family
A6F68_02566	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F68_02567	COG0233	cytoplasmic translational termination
A6F68_02568	COG0528	UMP kinase activity
A6F68_02571	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6F68_02572	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F68_02575	COG0688	phosphatidylethanolamine metabolic process
A6F68_02580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F68_02582	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_02586	COG2130	NADP-dependent
A6F68_02588	COG4771	TonB-dependent receptor
A6F68_02589	COG3038	cytochrome b561
A6F68_02595	COG1024	Enoyl-CoA hydratase
A6F68_02597	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_02599	COG0154	amidase activity
A6F68_02604	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_02605	COG1960	acyl-CoA dehydrogenase activity
A6F68_02609	COG4771	TonB-dependent receptor
A6F68_02611	COG4774	siderophore transport
A6F68_02615	COG0277	FAD linked oxidase domain protein
A6F68_02621	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_02624	COG1335	isochorismatase
A6F68_02627	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F68_02629	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F68_02630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F68_02634	COG4106	trans-aconitate 2-methyltransferase activity
A6F68_02639	COG2267	carboxylic ester hydrolase activity
A6F68_02643	COG1028	Short-chain dehydrogenase reductase Sdr
A6F68_02649	COG0612	Peptidase, M16
A6F68_02651	COG0642	Histidine kinase
A6F68_02652	COG0745	RESPONSE REGULATOR receiver
A6F68_02657	COG0420	3'-5' exonuclease activity
A6F68_02663	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F68_02666	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6F68_02668	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6F68_02671	COG1643	Atp-dependent helicase
A6F68_02672	COG0142	geranyltranstransferase activity
A6F68_02673	COG0287	Prephenate dehydrogenase
A6F68_02673	COG1605	Chorismate mutase
A6F68_02674	COG2205	protein histidine kinase activity
A6F68_02675	COG0745	RESPONSE REGULATOR receiver
A6F68_02683	COG0438	transferase activity, transferring glycosyl groups
A6F68_02684	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F68_02685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F68_02690	COG1522	sequence-specific DNA binding
A6F68_02691	COG1609	Transcriptional regulator
A6F68_02695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F68_02696	COG0511	ligase activity, forming carbon-carbon bonds
A6F68_02697	COG0439	Biotin carboxylase
A6F68_02698	COG2235	arginine
A6F68_02699	COG1278	Cold shock
A6F68_02701	COG1522	sequence-specific DNA binding
A6F68_02702	COG2205	protein histidine kinase activity
A6F68_02709	COG0488	(ABC) transporter
A6F68_02712	COG4771	TonB-dependent receptor
A6F68_02715	COG0583	DNA-binding transcription factor activity
A6F68_02716	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F68_02719	COG3181	Tripartite tricarboxylate transporter family receptor
A6F68_02723	COG1053	succinate dehydrogenase
A6F68_02727	COG0488	(ABC) transporter
A6F68_02730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6F68_02737	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F68_02738	COG2205	protein histidine kinase activity
A6F68_02738	COG0784	Response regulator, receiver
A6F68_02739	COG1199	ATP-dependent helicase activity
A6F68_02739	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F68_02740	COG2062	phosphohistidine phosphatase, SixA
A6F68_02741	COG0789	Transcriptional regulator
A6F68_02744	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6F68_02750	COG0438	transferase activity, transferring glycosyl groups
A6F68_02751	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F68_02754	COG1012	belongs to the aldehyde dehydrogenase family
A6F68_02758	COG0418	dihydroorotase activity
A6F68_02762	COG3485	protocatechuate 3,4-dioxygenase
A6F68_02767	COG1671	Belongs to the UPF0178 family
A6F68_02775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F68_02778	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F68_02779	COG2072	flavoprotein involved in K transport
A6F68_02781	COG0784	Response regulator, receiver
A6F68_02781	COG2198	Histidine kinase
A6F68_02781	COG5002	protein histidine kinase activity
A6F68_02789	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F68_02790	COG2814	Major facilitator Superfamily
A6F68_02793	COG0494	nUDIX hydrolase
A6F68_02799	COG2197	response regulator
A6F68_02807	COG1024	Enoyl-CoA hydratase
A6F68_02808	COG1024	Enoyl-CoA hydratase
A6F68_02811	COG0805	protein transport
A6F68_02812	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F68_02813	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F68_02814	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F68_02815	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F68_02816	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F68_02818	COG0018	arginyl-trna synthetase
A6F68_02820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F68_02821	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F68_02822	COG0328	RNA-DNA hybrid ribonuclease activity
A6F68_02823	COG3422	double-strand break repair
A6F68_02828	COG4964	Belongs to the GSP D family
A6F68_02834	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6F68_02835	COG1024	Enoyl-CoA hydratase
A6F68_02844	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F68_02846	COG0612	Peptidase, M16
A6F68_02850	COG0322	excinuclease ABC activity
A6F68_02851	COG2081	HI0933 family
A6F68_02853	COG0596	Alpha beta hydrolase
A6F68_02856	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F68_02857	COG0424	maF-like protein
A6F68_02862	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6F68_02864	COG0612	Peptidase, M16
A6F68_02866	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F68_02867	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F68_02868	COG5001	Diguanylate cyclase
A6F68_02869	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F68_02873	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6F68_02879	COG0697	spore germination
A6F68_02882	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F68_02883	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F68_02885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F68_02887	COG0646	methionine synthase
A6F68_02887	COG1410	methionine synthase
A6F68_02890	COG2226	methyltransferase
A6F68_02892	COG4608	Belongs to the ABC transporter superfamily
A6F68_02893	COG0444	Belongs to the ABC transporter superfamily
A6F68_02894	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6F68_02895	COG0601	transmembrane transport
A6F68_02899	COG0405	Gamma-glutamyltransferase
A6F68_02906	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F68_02914	COG2850	peptidyl-arginine hydroxylation
A6F68_02917	COG0488	(ABC) transporter
A6F68_02926	COG5265	(ABC) transporter
A6F68_02931	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6F68_02932	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F68_02936	COG0629	single-stranded DNA binding
A6F68_02940	COG0666	response to abiotic stimulus
A6F68_02941	COG1999	signal sequence binding
A6F68_02942	COG2983	Belongs to the UPF0260 family
A6F68_02945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F68_02945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F68_02947	COG0756	dUTP diphosphatase activity
A6F68_02948	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F68_02950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F68_02951	COG2226	methyltransferase
A6F68_02952	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6F68_02953	COG0268	Binds directly to 16S ribosomal RNA