locus-tag	class	description
A6F65_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6F65_00002	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6F65_00005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6F65_00006	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6F65_00012	COG1301	dicarboxylic acid transport
A6F65_00013	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F65_00014	COG0625	glutathione transferase activity
A6F65_00017	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6F65_00018	COG0706	membrane insertase activity
A6F65_00019	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6F65_00020	COG0594	ribonuclease P activity
A6F65_00021	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6F65_00024	COG0606	chelatase, subunit chli
A6F65_00026	COG0531	amino acid
A6F65_00036	COG0154	amidase activity
A6F65_00040	COG2186	Transcriptional regulator
A6F65_00041	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_00042	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_00043	COG1960	acyl-CoA dehydrogenase activity
A6F65_00045	COG2301	Belongs to the HpcH HpaI aldolase family
A6F65_00048	COG4771	TonB-dependent receptor
A6F65_00050	COG4771	TonB-dependent receptor
A6F65_00053	COG0277	FAD linked oxidase domain protein
A6F65_00053	COG0247	lactate metabolic process
A6F65_00056	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_00059	COG1335	isochorismatase
A6F65_00062	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F65_00064	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F65_00067	COG1522	sequence-specific DNA binding
A6F65_00069	COG2271	Major facilitator Superfamily
A6F65_00071	COG2130	NADP-dependent
A6F65_00076	COG2226	methyltransferase
A6F65_00078	COG1733	regulation of RNA biosynthetic process
A6F65_00081	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6F65_00084	COG2866	Carboxypeptidase
A6F65_00086	COG0295	cytidine deaminase activity
A6F65_00088	COG5328	Belongs to the UPF0262 family
A6F65_00089	COG0305	Participates in initiation and elongation during chromosome replication
A6F65_00091	COG1758	RNA polymerase activity
A6F65_00095	COG1482	cell wall glycoprotein biosynthetic process
A6F65_00097	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6F65_00099	COG3383	formate dehydrogenase (NAD+) activity
A6F65_00100	COG0746	molybdenum cofactor guanylyltransferase activity
A6F65_00103	COG0583	DNA-binding transcription factor activity
A6F65_00105	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F65_00105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_00107	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6F65_00111	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_00112	COG0583	DNA-binding transcription factor activity
A6F65_00113	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6F65_00114	COG0457	Tetratricopeptide repeat
A6F65_00115	COG4771	TonB-dependent receptor
A6F65_00116	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6F65_00117	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6F65_00118	COG0583	DNA-binding transcription factor activity
A6F65_00120	COG4638	Rieske (2fe-2S)
A6F65_00122	COG0006	proline dipeptidase activity
A6F65_00124	COG5598	trimethylamine methyltransferase
A6F65_00131	COG5012	cobalamin binding
A6F65_00135	COG2175	clavaminate synthase activity
A6F65_00137	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_00137	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6F65_00141	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F65_00151	COG0582	viral genome integration into host DNA
A6F65_00155	COG0330	HflC and HflK could
A6F65_00157	COG3118	belongs to the thioredoxin family
A6F65_00158	COG3118	belongs to the thioredoxin family
A6F65_00164	COG2070	2-Nitropropane dioxygenase
A6F65_00166	COG0527	aspartate kinase activity
A6F65_00167	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_00168	COG0584	glycerophosphoryl diester phosphodiesterase
A6F65_00169	COG1393	Belongs to the ArsC family
A6F65_00172	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6F65_00174	COG0217	transcriptional regulatory protein
A6F65_00176	COG0393	Putative heavy-metal-binding
A6F65_00177	COG3750	Belongs to the UPF0335 family
A6F65_00179	COG0469	pyruvate kinase activity
A6F65_00180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A6F65_00182	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F65_00182	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_00184	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6F65_00185	COG0085	RNA polymerase activity
A6F65_00188	COG3655	Transcriptional regulator
A6F65_00191	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6F65_00192	COG0222	ribosome binding
A6F65_00195	COG0596	Alpha beta hydrolase
A6F65_00196	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6F65_00196	COG0475	glutathione-regulated potassium exporter activity
A6F65_00197	COG0534	Mate efflux family protein
A6F65_00198	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6F65_00199	COG0459	protein refolding
A6F65_00203	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_00203	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_00204	COG3920	Histidine kinase
A6F65_00206	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6F65_00210	COG2814	Major facilitator Superfamily
A6F65_00216	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6F65_00217	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6F65_00219	COG2890	protein-(glutamine-N5) methyltransferase activity
A6F65_00220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6F65_00221	COG0124	histidyl-tRNA synthetase
A6F65_00222	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6F65_00225	COG0668	transmembrane transport
A6F65_00227	COG1137	ATPase activity
A6F65_00228	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6F65_00229	COG0745	RESPONSE REGULATOR receiver
A6F65_00230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6F65_00231	COG1988	membrane-bound metal-dependent
A6F65_00234	COG0281	malic enzyme
A6F65_00234	COG0280	phosphate acetyltransferase
A6F65_00235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6F65_00240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_00244	COG3483	tryptophan 2,3-dioxygenase activity
A6F65_00246	COG0747	negative chemotaxis
A6F65_00248	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F65_00257	COG0156	8-amino-7-oxononanoate synthase activity
A6F65_00258	COG1764	response to oxidative stress
A6F65_00263	COG4695	Portal protein
A6F65_00279	COG2032	superoxide dismutase activity
A6F65_00280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6F65_00281	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6F65_00282	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6F65_00283	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6F65_00284	COG1278	Cold shock
A6F65_00285	COG1253	flavin adenine dinucleotide binding
A6F65_00288	COG2885	chlorophyll binding
A6F65_00288	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6F65_00289	COG0004	ammonium transporteR
A6F65_00290	COG0347	Belongs to the P(II) protein family
A6F65_00293	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6F65_00294	COG4221	oxidoreductase activity
A6F65_00295	COG0072	phenylalanine-tRNA ligase activity
A6F65_00296	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6F65_00297	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6F65_00298	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6F65_00302	COG1494	fructose-1,6-bisphosphatase
A6F65_00310	COG1201	RNA secondary structure unwinding
A6F65_00314	COG1192	Involved in chromosome partitioning
A6F65_00315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6F65_00316	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F65_00317	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6F65_00318	COG0509	glycine decarboxylation via glycine cleavage system
A6F65_00319	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6F65_00320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6F65_00323	COG1396	sequence-specific DNA binding
A6F65_00323	COG3800	Transcriptional regulator
A6F65_00325	COG2885	chlorophyll binding
A6F65_00327	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6F65_00332	COG0308	aminopeptidase N
A6F65_00337	COG3428	Bacterial PH domain
A6F65_00341	COG0588	phosphoglycerate mutase activity
A6F65_00343	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6F65_00346	COG0196	riboflavin kinase activity
A6F65_00347	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6F65_00348	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6F65_00350	COG1253	flavin adenine dinucleotide binding
A6F65_00351	COG2885	chlorophyll binding
A6F65_00352	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_00353	COG0045	succinate-CoA ligase (ADP-forming) activity
A6F65_00356	COG2086	electron transfer activity
A6F65_00360	COG2733	membrane
A6F65_00362	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6F65_00366	COG0482	sulfurtransferase activity
A6F65_00372	COG0259	pyridoxamine-phosphate oxidase activity
A6F65_00373	COG0484	heat shock protein binding
A6F65_00374	COG1295	ribonuclease BN
A6F65_00375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6F65_00381	COG0793	Belongs to the peptidase S41A family
A6F65_00382	COG4942	peptidase
A6F65_00383	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6F65_00384	COG0799	negative regulation of ribosome biogenesis
A6F65_00385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6F65_00386	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6F65_00387	COG0739	heme binding
A6F65_00394	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6F65_00394	COG1793	dna ligase
A6F65_00396	COG1793	dna ligase
A6F65_00398	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6F65_00401	COG0113	porphobilinogen synthase activity
A6F65_00402	COG0739	heme binding
A6F65_00404	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F65_00407	COG1329	Transcriptional regulator
A6F65_00413	COG1956	GAF domain-containing protein
A6F65_00418	COG1475	DNA binding
A6F65_00419	COG1192	Involved in chromosome partitioning
A6F65_00420	COG0357	Ribosomal RNA small subunit methyltransferase G
A6F65_00421	COG0445	tRNA wobble uridine modification
A6F65_00422	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6F65_00425	COG0069	glutamate synthase activity
A6F65_00428	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6F65_00430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6F65_00431	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6F65_00432	COG0424	maF-like protein
A6F65_00433	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6F65_00434	COG0237	dephospho-CoA kinase activity
A6F65_00435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6F65_00436	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6F65_00437	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F65_00442	COG0316	Belongs to the HesB IscA family
A6F65_00443	COG0517	IMP dehydrogenase activity
A6F65_00446	COG1506	peptidase
A6F65_00446	COG0823	Involved in the tonB-independent uptake of proteins
A6F65_00449	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6F65_00450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6F65_00450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6F65_00451	COG2972	Histidine kinase
A6F65_00456	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6F65_00457	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6F65_00460	COG1612	heme a metabolic process
A6F65_00462	COG2022	thiamine diphosphate biosynthetic process
A6F65_00465	COG1022	Amp-dependent synthetase and ligase
A6F65_00466	COG0405	Gamma-glutamyltransferase
A6F65_00467	COG0167	dihydroorotate dehydrogenase activity
A6F65_00468	COG1959	2 iron, 2 sulfur cluster binding
A6F65_00469	COG0719	Fe-S assembly protein
A6F65_00471	COG0396	ATPase activity
A6F65_00472	COG0719	Fe-S assembly protein
A6F65_00473	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6F65_00474	COG2151	metal-sulfur cluster biosynthetic enzyme
A6F65_00476	COG0316	Belongs to the HesB IscA family
A6F65_00479	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6F65_00481	COG0151	Belongs to the GarS family
A6F65_00482	COG1570	exodeoxyribonuclease VII activity
A6F65_00484	COG0739	heme binding
A6F65_00486	COG0457	Tetratricopeptide repeat
A6F65_00487	COG0457	Tetratricopeptide repeat
A6F65_00488	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6F65_00489	COG0590	tRNA wobble adenosine to inosine editing
A6F65_00493	COG3279	Response regulator of the LytR AlgR family
A6F65_00494	COG3275	phosphorelay sensor kinase activity
A6F65_00505	COG4650	regulator
A6F65_00507	COG1690	Belongs to the RtcB family
A6F65_00509	COG0430	RNA-3'-phosphate cyclase activity
A6F65_00514	COG1082	Xylose isomerase domain protein TIM barrel
A6F65_00517	COG2188	Transcriptional regulator
A6F65_00519	COG0804	urea catabolic process
A6F65_00525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6F65_00527	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_00530	COG0138	bifunctional purine biosynthesis protein purh
A6F65_00541	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6F65_00541	COG0493	'glutamate synthase
A6F65_00546	COG4152	abc transporter atp-binding protein
A6F65_00547	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6F65_00549	COG2902	Dehydrogenase
A6F65_00555	COG0495	leucyl-tRNA aminoacylation
A6F65_00563	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6F65_00565	COG0739	heme binding
A6F65_00566	COG2833	Protein of unknown function (DUF455)
A6F65_00567	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F65_00568	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6F65_00570	COG2957	Belongs to the agmatine deiminase family
A6F65_00574	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6F65_00587	COG0438	transferase activity, transferring glycosyl groups
A6F65_00591	COG1216	Glycosyl transferase, family 2
A6F65_00592	COG0297	glycogen (starch) synthase activity
A6F65_00593	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F65_00594	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6F65_00598	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6F65_00599	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6F65_00601	COG0070	glutamate synthase
A6F65_00601	COG0067	glutamate synthase
A6F65_00601	COG0069	glutamate synthase activity
A6F65_00603	COG0438	transferase activity, transferring glycosyl groups
A6F65_00608	COG1132	(ABC) transporter
A6F65_00609	COG3590	peptidase
A6F65_00610	COG1968	undecaprenyl-diphosphatase activity
A6F65_00613	COG3186	Phenylalanine-4-hydroxylase
A6F65_00616	COG0514	ATP-dependent DNA helicase (RecQ)
A6F65_00619	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6F65_00620	COG0688	phosphatidylethanolamine metabolic process
A6F65_00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6F65_00627	COG0564	pseudouridine synthase activity
A6F65_00630	COG0433	COG0433 Predicted ATPase
A6F65_00633	COG2205	protein histidine kinase activity
A6F65_00639	COG0513	Belongs to the DEAD box helicase family
A6F65_00643	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6F65_00646	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6F65_00647	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6F65_00650	COG1960	acyl-CoA dehydrogenase activity
A6F65_00651	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F65_00657	COG0187	DNA topoisomerase II activity
A6F65_00658	COG1760	l-serine dehydratase
A6F65_00659	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6F65_00659	COG0519	Catalyzes the synthesis of GMP from XMP
A6F65_00663	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6F65_00670	COG1131	(ABC) transporter
A6F65_00676	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F65_00676	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6F65_00688	COG2852	Protein conserved in bacteria
A6F65_00696	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6F65_00699	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6F65_00701	COG2095	MarC family integral membrane protein
A6F65_00705	COG4771	TonB-dependent receptor
A6F65_00706	COG3268	Saccharopine dehydrogenase
A6F65_00707	COG0717	Belongs to the dCTP deaminase family
A6F65_00708	COG0506	proline dehydrogenase activity
A6F65_00708	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F65_00708	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6F65_00711	COG2205	protein histidine kinase activity
A6F65_00714	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6F65_00717	COG1024	Enoyl-CoA hydratase
A6F65_00724	COG1136	(ABC) transporter
A6F65_00724	COG0577	efflux transmembrane transporter activity
A6F65_00729	COG0587	DNA-directed DNA polymerase activity
A6F65_00730	COG2202	Pas domain
A6F65_00730	COG3920	Histidine kinase
A6F65_00734	COG2124	cytochrome p450
A6F65_00739	COG1609	Transcriptional regulator
A6F65_00742	COG1621	beta-fructofuranosidase activity
A6F65_00743	COG1940	carbohydrate kinase activity
A6F65_00747	COG2884	Cell division ATP-binding protein ftsE
A6F65_00750	COG0204	Acyl-transferase
A6F65_00751	COG0287	Prephenate dehydrogenase
A6F65_00752	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6F65_00753	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_00754	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_00754	COG2813	Specifically methylates the guanine in position
A6F65_00755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6F65_00758	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6F65_00762	COG2072	flavoprotein involved in K transport
A6F65_00763	COG1546	Belongs to the CinA family
A6F65_00763	COG1058	Belongs to the CinA family
A6F65_00765	COG0081	regulation of translation
A6F65_00766	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6F65_00770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6F65_00771	COG1115	amino acid carrier protein
A6F65_00776	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6F65_00781	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_00794	COG0784	Response regulator, receiver
A6F65_00794	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6F65_00794	COG2198	Histidine kinase
A6F65_00794	COG2205	protein histidine kinase activity
A6F65_00801	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6F65_00802	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6F65_00802	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F65_00804	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_00809	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6F65_00810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6F65_00810	COG2010	Cytochrome c
A6F65_00811	COG0489	protein tyrosine kinase activity
A6F65_00816	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6F65_00818	COG1192	Involved in chromosome partitioning
A6F65_00829	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_00834	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6F65_00835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6F65_00836	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6F65_00837	COG1216	Glycosyl transferase, family 2
A6F65_00842	COG1132	(ABC) transporter
A6F65_00845	COG0366	Alpha amylase catalytic
A6F65_00852	COG1448	Aminotransferase
A6F65_00855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F65_00855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6F65_00859	COG2983	Belongs to the UPF0260 family
A6F65_00860	COG1999	signal sequence binding
A6F65_00865	COG0629	single-stranded DNA binding
A6F65_00870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6F65_00874	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6F65_00876	COG0659	secondary active sulfate transmembrane transporter activity
A6F65_00878	COG5265	(ABC) transporter
A6F65_00892	COG0175	sulfate reduction
A6F65_00894	COG1609	Transcriptional regulator
A6F65_00896	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6F65_00898	COG1024	Enoyl-CoA hydratase
A6F65_00899	COG1960	acyl-CoA dehydrogenase activity
A6F65_00904	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F65_00907	COG3119	arylsulfatase activity
A6F65_00908	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F65_00909	COG1609	Transcriptional regulator
A6F65_00912	COG3119	arylsulfatase activity
A6F65_00914	COG3119	arylsulfatase activity
A6F65_00917	COG3119	arylsulfatase activity
A6F65_00918	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F65_00922	COG0783	Belongs to the Dps family
A6F65_00927	COG4989	oxidoreductase activity
A6F65_00941	COG1131	(ABC) transporter
A6F65_00946	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6F65_00949	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F65_00951	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6F65_00953	COG3040	lipid binding
A6F65_00955	COG1671	Belongs to the UPF0178 family
A6F65_00958	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_00961	COG1278	Cold shock
A6F65_00963	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_00967	COG1881	PFAM PEBP family protein
A6F65_00976	COG2171	N-acyltransferase activity
A6F65_00978	COG1404	Belongs to the peptidase S8 family
A6F65_00979	COG0194	GDP metabolic process
A6F65_00982	COG0131	Imidazoleglycerol-phosphate dehydratase
A6F65_00983	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6F65_00984	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6F65_00985	COG0107	imidazoleglycerol-phosphate synthase activity
A6F65_00987	COG0140	phosphoribosyl-ATP diphosphatase activity
A6F65_00992	COG0848	biopolymer transport protein
A6F65_00994	COG0823	Involved in the tonB-independent uptake of proteins
A6F65_00995	COG2885	chlorophyll binding
A6F65_00997	COG0484	heat shock protein binding
A6F65_00999	COG0626	cystathionine gamma-synthase activity
A6F65_01002	COG0471	metal ion transport
A6F65_01006	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6F65_01008	COG0408	coproporphyrinogen oxidase activity
A6F65_01011	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6F65_01012	COG0569	domain protein
A6F65_01020	COG0477	Major facilitator Superfamily
A6F65_01024	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6F65_01027	COG1609	Transcriptional regulator
A6F65_01029	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_01032	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6F65_01033	COG1960	acyl-CoA dehydrogenase activity
A6F65_01037	COG0726	polysaccharide deacetylase
A6F65_01038	COG1024	Enoyl-CoA hydratase
A6F65_01045	COG0346	lactoylglutathione lyase activity
A6F65_01048	COG0686	Belongs to the AlaDH PNT family
A6F65_01049	COG3755	Protein conserved in bacteria
A6F65_01051	COG0784	Response regulator, receiver
A6F65_01056	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6F65_01057	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6F65_01058	COG0181	hydroxymethylbilane synthase activity
A6F65_01061	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6F65_01064	COG0556	nucleotide-excision repair
A6F65_01067	COG0596	Alpha beta hydrolase
A6F65_01067	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6F65_01067	COG2226	methyltransferase
A6F65_01068	COG2308	Evidence 4 Homologs of previously reported genes of
A6F65_01072	COG4566	intracellular signal transduction
A6F65_01075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6F65_01076	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F65_01077	COG0784	Response regulator, receiver
A6F65_01079	COG0656	L-ascorbic acid biosynthetic process
A6F65_01080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6F65_01084	COG0252	asparaginase activity
A6F65_01088	COG0165	Argininosuccinate lyase
A6F65_01090	COG0019	diaminopimelate decarboxylase activity
A6F65_01091	COG1648	precorrin-2 dehydrogenase activity
A6F65_01091	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F65_01095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6F65_01097	COG0628	permease
A6F65_01099	COG0736	holo-[acyl-carrier-protein] synthase activity
A6F65_01100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6F65_01101	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6F65_01102	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6F65_01103	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6F65_01104	COG0109	protoheme IX farnesyltransferase activity
A6F65_01106	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6F65_01113	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6F65_01117	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6F65_01119	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6F65_01120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6F65_01123	COG2197	response regulator
A6F65_01124	COG4585	Histidine kinase
A6F65_01130	COG0424	maF-like protein
A6F65_01131	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6F65_01133	COG2081	HI0933 family
A6F65_01134	COG0322	excinuclease ABC activity
A6F65_01140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6F65_01143	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6F65_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6F65_01146	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6F65_01147	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6F65_01149	COG0596	Alpha beta hydrolase
A6F65_01150	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F65_01151	COG1741	Belongs to the pirin family
A6F65_01155	COG5507	3-demethylubiquinone-9 3-methyltransferase
A6F65_01157	COG5001	Diguanylate cyclase
A6F65_01158	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6F65_01159	COG0101	tRNA pseudouridine synthase activity
A6F65_01160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6F65_01161	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6F65_01162	COG0242	peptide deformylase activity
A6F65_01165	COG1322	Protein conserved in bacteria
A6F65_01167	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F65_01169	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6F65_01169	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6F65_01170	COG1660	Displays ATPase and GTPase activities
A6F65_01172	COG0642	Histidine kinase
A6F65_01173	COG0745	RESPONSE REGULATOR receiver
A6F65_01174	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6F65_01179	COG0492	ferredoxin-NADP+ reductase activity
A6F65_01185	COG2945	thiolester hydrolase activity
A6F65_01187	COG1104	cysteine desulfurase activity
A6F65_01191	COG0693	protein deglycase activity
A6F65_01192	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F65_01193	COG5002	protein histidine kinase activity
A6F65_01193	COG0784	Response regulator, receiver
A6F65_01194	COG0617	tRNA 3'-terminal CCA addition
A6F65_01198	COG2133	pyrroloquinoline quinone binding
A6F65_01199	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6F65_01200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_01202	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6F65_01203	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6F65_01204	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_01207	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F65_01209	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6F65_01210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6F65_01213	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6F65_01218	COG0697	spore germination
A6F65_01223	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6F65_01225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6F65_01226	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6F65_01228	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6F65_01229	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F65_01234	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6F65_01234	COG2169	Transcriptional regulator
A6F65_01236	COG1196	nuclear chromosome segregation
A6F65_01238	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_01238	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6F65_01240	COG1194	a g-specific adenine glycosylase
A6F65_01247	COG2239	Acts as a magnesium transporter
A6F65_01248	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F65_01251	COG0583	DNA-binding transcription factor activity
A6F65_01252	COG1253	flavin adenine dinucleotide binding
A6F65_01253	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6F65_01256	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_01260	COG4957	zinc ion binding
A6F65_01263	COG0778	Nitroreductase
A6F65_01264	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6F65_01265	COG0612	Peptidase, M16
A6F65_01266	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6F65_01267	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6F65_01271	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6F65_01272	COG0625	glutathione transferase activity
A6F65_01278	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6F65_01280	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6F65_01283	COG1381	Involved in DNA repair and RecF pathway recombination
A6F65_01284	COG0473	3-isopropylmalate dehydrogenase activity
A6F65_01291	COG2967	ApaG domain
A6F65_01302	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6F65_01304	COG0049	tRNA binding
A6F65_01305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6F65_01306	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6F65_01307	COG0051	transcription antitermination factor activity, RNA binding
A6F65_01308	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6F65_01309	COG0088	Forms part of the polypeptide exit tunnel
A6F65_01310	COG0089	rRNA binding
A6F65_01311	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6F65_01312	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6F65_01313	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6F65_01314	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6F65_01315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6F65_01316	COG0255	Belongs to the universal ribosomal protein uL29 family
A6F65_01317	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6F65_01318	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6F65_01319	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6F65_01320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6F65_01321	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6F65_01322	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6F65_01323	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6F65_01324	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6F65_01325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6F65_01326	COG1841	ribosomal large subunit assembly
A6F65_01328	COG0200	Binds to the 23S rRNA
A6F65_01329	COG0201	protein transport
A6F65_01330	COG0563	adenylate kinase activity
A6F65_01333	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6F65_01334	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6F65_01335	COG0202	RNA polymerase activity
A6F65_01336	COG0203	ribosomal protein L17
A6F65_01337	COG1505	serine-type exopeptidase activity
A6F65_01340	COG2860	membrane
A6F65_01343	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F65_01345	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_01347	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6F65_01349	COG0039	L-malate dehydrogenase activity
A6F65_01350	COG3300	MHYT domain
A6F65_01350	COG5001	Diguanylate cyclase
A6F65_01353	COG4206	TonB-dependent receptor
A6F65_01356	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6F65_01361	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6F65_01364	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6F65_01369	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F65_01370	COG0137	argininosuccinate synthase activity
A6F65_01372	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6F65_01373	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A6F65_01375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F65_01378	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6F65_01379	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6F65_01382	COG2268	Band 7 protein
A6F65_01384	COG0741	lytic transglycosylase activity
A6F65_01385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6F65_01387	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6F65_01392	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6F65_01393	COG4106	trans-aconitate 2-methyltransferase activity
A6F65_01394	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6F65_01397	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6F65_01398	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F65_01398	COG3153	acetyltransferase
A6F65_01399	COG0538	isocitrate dehydrogenase activity
A6F65_01404	COG1960	acyl-CoA dehydrogenase activity
A6F65_01405	COG1024	Enoyl-CoA hydratase
A6F65_01405	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6F65_01406	COG0183	Belongs to the thiolase family
A6F65_01407	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_01408	COG0789	Transcriptional regulator
A6F65_01417	COG0210	DNA helicase
A6F65_01421	COG0742	ribosomal rna small subunit methyltransferase
A6F65_01423	COG1187	pseudouridine synthase activity
A6F65_01424	COG2223	nitrite transmembrane transporter activity
A6F65_01425	COG0285	dihydrofolate synthase activity
A6F65_01426	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6F65_01427	COG0159	tryptophan synthase activity
A6F65_01428	COG2852	Protein conserved in bacteria
A6F65_01429	COG0133	tryptophan synthase activity
A6F65_01430	COG0135	phosphoribosylanthranilate isomerase activity
A6F65_01432	COG0284	orotidine-5'-phosphate decarboxylase activity
A6F65_01434	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6F65_01435	COG2003	Belongs to the UPF0758 family
A6F65_01440	COG0356	it plays a direct role in the translocation of protons across the membrane
A6F65_01441	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6F65_01442	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F65_01443	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6F65_01445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F65_01446	COG0539	negative regulation of cytoplasmic translation
A6F65_01448	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6F65_01450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6F65_01453	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6F65_01454	COG0228	four-way junction DNA binding
A6F65_01455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6F65_01459	COG0336	Belongs to the RNA methyltransferase TrmD family
A6F65_01460	COG0335	large ribosomal subunit rRNA binding
A6F65_01464	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6F65_01470	COG0189	ligase activity
A6F65_01470	COG4067	protein conserved in archaea
A6F65_01471	COG0189	ligase activity
A6F65_01473	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6F65_01474	COG0359	binds to the 23S rRNA
A6F65_01475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6F65_01476	COG0360	Binds together with S18 to 16S ribosomal RNA
A6F65_01477	COG2354	Protein conserved in bacteria
A6F65_01479	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F65_01480	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6F65_01481	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6F65_01485	COG0592	DNA-directed DNA polymerase activity
A6F65_01487	COG0493	'glutamate synthase
A6F65_01488	COG5001	Diguanylate cyclase
A6F65_01488	COG3300	MHYT domain
A6F65_01489	COG5001	Diguanylate cyclase
A6F65_01489	COG3300	MHYT domain
A6F65_01490	COG0481	GTPase activity
A6F65_01495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6F65_01499	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6F65_01501	COG4221	oxidoreductase activity
A6F65_01505	COG2264	protein methyltransferase activity
A6F65_01509	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6F65_01516	COG2321	neutral zinc metallopeptidase
A6F65_01517	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_01521	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6F65_01523	COG1051	belongs to the nudix hydrolase family
A6F65_01524	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6F65_01524	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6F65_01525	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6F65_01527	COG1902	pentaerythritol trinitrate reductase activity
A6F65_01529	COG0415	Belongs to the DNA photolyase family
A6F65_01530	COG2264	protein methyltransferase activity
A6F65_01534	COG0300	oxidoreductase activity
A6F65_01535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6F65_01537	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6F65_01544	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6F65_01548	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6F65_01549	COG0126	phosphoglycerate kinase activity
A6F65_01551	COG3588	fructose-bisphosphate aldolase
A6F65_01553	COG0352	thiamine-phosphate diphosphorylase activity
A6F65_01554	COG1376	ErfK ybiS ycfS ynhG family protein
A6F65_01555	COG0741	lytic transglycosylase activity
A6F65_01555	COG0739	heme binding
A6F65_01555	COG1196	nuclear chromosome segregation
A6F65_01557	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6F65_01558	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_01563	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6F65_01564	COG4191	Histidine kinase
A6F65_01565	COG2204	response regulator
A6F65_01567	COG0385	Bile acid
A6F65_01569	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6F65_01570	COG0733	neurotransmitter:sodium symporter activity
A6F65_01572	COG3338	carbonate dehydratase activity
A6F65_01574	COG1573	uracil-dna glycosylase
A6F65_01575	COG1280	lysine exporter protein (LysE YggA)
A6F65_01577	COG0745	RESPONSE REGULATOR receiver
A6F65_01578	COG0704	Plays a role in the regulation of phosphate uptake
A6F65_01579	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6F65_01581	COG0573	inorganic phosphate transmembrane transporter activity
A6F65_01583	COG3746	phosphate-selective porin O and P
A6F65_01584	COG5002	protein histidine kinase activity
A6F65_01586	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6F65_01590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6F65_01593	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6F65_01596	COG0028	Belongs to the TPP enzyme family
A6F65_01597	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6F65_01601	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F65_01602	COG1722	exodeoxyribonuclease VII activity
A6F65_01603	COG0142	geranyltranstransferase activity
A6F65_01604	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6F65_01605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6F65_01606	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6F65_01608	COG1131	(ABC) transporter
A6F65_01609	COG0842	Transport permease protein
A6F65_01611	COG0343	queuine tRNA-ribosyltransferase activity
A6F65_01613	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6F65_01618	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6F65_01619	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6F65_01620	COG0698	ribose 5-phosphate isomerase
A6F65_01621	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F65_01622	COG0358	DNA primase activity
A6F65_01625	COG0505	Belongs to the CarA family
A6F65_01627	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6F65_01633	COG0148	phosphopyruvate hydratase activity
A6F65_01634	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6F65_01636	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6F65_01640	COG0772	Belongs to the SEDS family
A6F65_01643	COG1792	Involved in formation and maintenance of cell shape
A6F65_01645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6F65_01651	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6F65_01652	COG2867	negative regulation of translational initiation
A6F65_01655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6F65_01655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6F65_01657	COG3852	Histidine kinase
A6F65_01658	COG2204	response regulator
A6F65_01659	COG5000	phosphorelay sensor kinase activity
A6F65_01660	COG2204	response regulator
A6F65_01662	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6F65_01663	COG3956	TIGRFAM MazG family protein
A6F65_01664	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6F65_01666	COG1234	tRNA 3'-trailer cleavage
A6F65_01667	COG0084	hydrolase, TatD family'
A6F65_01669	COG0470	DNA polymerase III
A6F65_01670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6F65_01672	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6F65_01673	COG2951	lytic endotransglycosylase activity
A6F65_01676	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6F65_01678	COG1607	acyl-coa hydrolase
A6F65_01679	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_01682	COG0557	exoribonuclease II activity
A6F65_01683	COG0442	prolyl-tRNA aminoacylation
A6F65_01685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6F65_01688	COG1286	toxin biosynthetic process
A6F65_01690	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6F65_01691	COG0484	heat shock protein binding
A6F65_01692	COG0443	Heat shock 70 kDa protein
A6F65_01697	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6F65_01698	COG1420	regulation of RNA biosynthetic process
A6F65_01699	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6F65_01700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6F65_01702	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6F65_01703	COG4974	Belongs to the 'phage' integrase family
A6F65_01704	COG0586	Pfam SNARE associated Golgi protein
A6F65_01705	COG0189	ligase activity
A6F65_01706	COG0792	nuclease activity
A6F65_01707	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6F65_01708	COG3107	peptidoglycan biosynthetic process
A6F65_01709	COG0187	DNA topoisomerase II activity
A6F65_01715	COG3876	Protein conserved in bacteria
A6F65_01717	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6F65_01721	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6F65_01724	COG0574	Belongs to the PEP-utilizing enzyme family
A6F65_01724	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6F65_01725	COG0751	glycine-tRNA ligase activity
A6F65_01726	COG0752	glycyl-tRNA synthetase alpha subunit
A6F65_01732	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6F65_01733	COG0193	aminoacyl-tRNA hydrolase activity
A6F65_01734	COG0012	GTP binding
A6F65_01736	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6F65_01740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6F65_01749	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6F65_01749	COG0022	dehydrogenase e1 component
A6F65_01750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6F65_01753	COG3088	subunit of a heme lyase
A6F65_01754	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6F65_01755	COG1138	Cytochrome C-type biogenesis protein
A6F65_01756	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6F65_01758	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F65_01762	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6F65_01763	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6F65_01764	COG0071	Belongs to the small heat shock protein (HSP20) family
A6F65_01765	COG0504	CTP synthase activity
A6F65_01767	COG0149	triose-phosphate isomerase activity
A6F65_01769	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6F65_01774	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6F65_01775	COG0134	indole-3-glycerol-phosphate synthase activity
A6F65_01776	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6F65_01777	COG0315	cyclic pyranopterin monophosphate synthase activity
A6F65_01778	COG0303	'Molybdopterin
A6F65_01779	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6F65_01780	COG2333	competence protein COMEC
A6F65_01780	COG0658	competence protein
A6F65_01781	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6F65_01782	COG0372	Belongs to the citrate synthase family
A6F65_01784	COG2205	protein histidine kinase activity
A6F65_01791	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6F65_01793	COG1007	ATP synthesis coupled electron transport
A6F65_01796	COG0713	ATP synthesis coupled electron transport
A6F65_01798	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_01799	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6F65_01806	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6F65_01810	COG0649	NAD binding
A6F65_01812	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_01813	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_01814	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6F65_01815	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_01816	COG0183	Belongs to the thiolase family
A6F65_01819	COG0004	ammonium transporteR
A6F65_01821	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F65_01823	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6F65_01826	COG1530	ribonuclease E activity
A6F65_01830	COG1216	Glycosyl transferase, family 2
A6F65_01832	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6F65_01833	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6F65_01841	COG3409	Peptidoglycan-binding domain 1 protein
A6F65_01841	COG3267	Type II secretory pathway component ExeA
A6F65_01847	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_01852	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6F65_01854	COG0129	dihydroxy-acid dehydratase activity
A6F65_01856	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6F65_01860	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6F65_01861	COG0530	calcium, potassium:sodium antiporter activity
A6F65_01863	COG0318	PFAM AMP-dependent synthetase and ligase
A6F65_01864	COG0587	DNA-directed DNA polymerase activity
A6F65_01866	COG1136	(ABC) transporter
A6F65_01868	COG3706	GGDEF domain
A6F65_01869	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6F65_01871	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6F65_01873	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6F65_01875	COG0653	protein targeting
A6F65_01880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6F65_01881	COG0483	inositol monophosphate 1-phosphatase activity
A6F65_01885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6F65_01886	COG3178	'Phosphotransferase
A6F65_01887	COG0802	atpase or kinase
A6F65_01888	COG2205	protein histidine kinase activity
A6F65_01889	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6F65_01890	COG0678	peroxiredoxin activity
A6F65_01893	COG1309	transcriptional regulator
A6F65_01894	COG0302	gtp cyclohydrolase
A6F65_01895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6F65_01902	COG0825	malonyl-CoA metabolic process
A6F65_01903	COG4974	Belongs to the 'phage' integrase family
A6F65_01906	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6F65_01907	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6F65_01910	COG0166	Belongs to the GPI family
A6F65_01911	COG0681	Belongs to the peptidase S26 family
A6F65_01912	COG0571	ribonuclease III activity
A6F65_01913	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6F65_01915	COG1754	DNA topoisomerase type I activity
A6F65_01915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6F65_01920	COG0758	DNA mediated transformation
A6F65_01921	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6F65_01922	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6F65_01923	COG0156	8-amino-7-oxononanoate synthase activity
A6F65_01924	COG5001	Diguanylate cyclase
A6F65_01924	COG3300	MHYT domain
A6F65_01926	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A6F65_01931	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6F65_01932	COG3387	PFAM Glycoside hydrolase 15-related
A6F65_01933	COG1877	trehalose-phosphatase activity
A6F65_01937	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6F65_01938	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6F65_01939	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6F65_01941	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6F65_01943	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6F65_01944	COG0583	DNA-binding transcription factor activity
A6F65_01946	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6F65_01947	COG2814	Major facilitator Superfamily
A6F65_01949	COG0028	Belongs to the TPP enzyme family
A6F65_01951	COG5001	Diguanylate cyclase
A6F65_01951	COG3300	MHYT domain
A6F65_01952	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6F65_01953	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_01954	COG0552	protein localization to endoplasmic reticulum
A6F65_01955	COG2917	probably involved in intracellular septation
A6F65_01956	COG3158	transport of potassium into the cell
A6F65_01961	COG0254	rRNA binding
A6F65_01962	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6F65_01965	COG0750	zinc metalloprotease
A6F65_01966	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6F65_01968	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6F65_01969	COG0233	cytoplasmic translational termination
A6F65_01970	COG0528	UMP kinase activity
A6F65_01973	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6F65_01974	COG0052	Belongs to the universal ribosomal protein uS2 family
A6F65_01976	COG0688	phosphatidylethanolamine metabolic process
A6F65_01978	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6F65_01983	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6F65_01984	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6F65_01986	COG1643	Atp-dependent helicase
A6F65_01987	COG0142	geranyltranstransferase activity
A6F65_01988	COG1605	Chorismate mutase
A6F65_01988	COG0287	Prephenate dehydrogenase
A6F65_01989	COG3920	Histidine kinase
A6F65_01990	COG0784	Response regulator, receiver
A6F65_01992	COG2205	protein histidine kinase activity
A6F65_01993	COG0745	RESPONSE REGULATOR receiver
A6F65_01995	COG2968	Membrane
A6F65_02003	COG0438	transferase activity, transferring glycosyl groups
A6F65_02004	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F65_02005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6F65_02009	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6F65_02010	COG0511	ligase activity, forming carbon-carbon bonds
A6F65_02011	COG0439	Biotin carboxylase
A6F65_02014	COG1522	sequence-specific DNA binding
A6F65_02015	COG2205	protein histidine kinase activity
A6F65_02019	COG0534	Mate efflux family protein
A6F65_02022	COG2234	aminopeptidase activity
A6F65_02030	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6F65_02031	COG0668	transmembrane transport
A6F65_02032	COG1199	ATP-dependent helicase activity
A6F65_02035	COG0776	regulation of translation
A6F65_02036	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6F65_02037	COG0416	fatty acid biosynthetic process
A6F65_02038	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6F65_02040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6F65_02041	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6F65_02046	COG0215	cysteine-tRNA ligase activity
A6F65_02048	COG0215	cysteine-tRNA ligase activity
A6F65_02057	COG1410	methionine synthase
A6F65_02057	COG0646	methionine synthase
A6F65_02058	COG1733	regulation of RNA biosynthetic process
A6F65_02059	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6F65_02060	COG3046	protein related to deoxyribodipyrimidine photolyase
A6F65_02062	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6F65_02069	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6F65_02070	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_02074	COG0418	dihydroorotase activity
A6F65_02079	COG4771	TonB-dependent receptor
A6F65_02081	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6F65_02082	COG0612	Peptidase, M16
A6F65_02084	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6F65_02085	COG0047	phosphoribosylformylglycinamidine synthase activity
A6F65_02086	COG5001	Diguanylate cyclase
A6F65_02087	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6F65_02089	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6F65_02092	COG1045	serine acetyltransferase
A6F65_02095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6F65_02096	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6F65_02098	COG0105	UTP biosynthetic process
A6F65_02101	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F65_02102	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6F65_02103	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6F65_02104	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6F65_02105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6F65_02107	COG3138	arginine N-succinyltransferase
A6F65_02108	COG3724	N-succinylarginine dihydrolase activity
A6F65_02111	COG1970	mechanosensitive ion channel activity
A6F65_02114	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A6F65_02116	COG0494	nUDIX hydrolase
A6F65_02120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6F65_02122	COG2814	Major facilitator Superfamily
A6F65_02123	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_02127	COG1228	amidohydrolase
A6F65_02130	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_02137	COG3971	2-oxopent-4-enoate hydratase activity
A6F65_02139	COG1846	Transcriptional regulator
A6F65_02145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6F65_02150	COG4638	Rieske (2fe-2S)
A6F65_02154	COG0346	lactoylglutathione lyase activity
A6F65_02155	COG0277	FAD linked oxidase domain protein
A6F65_02157	COG1028	Short-chain dehydrogenase reductase Sdr
A6F65_02175	COG0842	Transport permease protein
A6F65_02178	COG1064	alcohol dehydrogenase
A6F65_02181	COG1185	polyribonucleotide nucleotidyltransferase activity
A6F65_02182	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6F65_02183	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6F65_02185	COG1994	Peptidase M50
A6F65_02186	COG1435	thymidine kinase activity
A6F65_02188	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6F65_02191	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6F65_02192	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6F65_02194	COG0779	Required for maturation of 30S ribosomal subunits
A6F65_02198	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6F65_02200	COG1842	Phage shock protein A
A6F65_02206	COG2166	iron-sulfur cluster assembly
A6F65_02207	COG0401	homolog of Blt101
A6F65_02211	COG0824	Thioesterase
A6F65_02213	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6F65_02216	COG0066	3-isopropylmalate dehydratase activity
A6F65_02218	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6F65_02222	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6F65_02224	COG4181	ATPase activity
A6F65_02227	COG4771	TonB-dependent receptor
A6F65_02228	COG5658	integral membrane protein
A6F65_02229	COG0640	Transcriptional regulator
A6F65_02232	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6F65_02235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6F65_02236	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6F65_02238	COG2897	thiosulfate sulfurtransferase activity
A6F65_02239	COG0626	cystathionine gamma-synthase activity
A6F65_02240	COG0668	transmembrane transport
A6F65_02241	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6F65_02241	COG1648	precorrin-2 dehydrogenase activity
A6F65_02243	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6F65_02245	COG0175	sulfate reduction
A6F65_02247	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6F65_02248	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6F65_02249	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6F65_02251	COG0670	Belongs to the BI1 family
A6F65_02252	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6F65_02255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6F65_02257	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6F65_02258	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6F65_02259	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6F65_02260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6F65_02261	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6F65_02263	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6F65_02264	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6F65_02265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6F65_02266	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6F65_02269	COG0275	rRNA processing
A6F65_02270	COG2001	Belongs to the MraZ family
A6F65_02279	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6F65_02280	COG4133	protoheme IX ABC transporter activity
A6F65_02281	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6F65_02282	COG0024	Methionine aminopeptidase
A6F65_02284	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6F65_02287	COG0347	Belongs to the P(II) protein family
A6F65_02288	COG0174	glutamine synthetase
A6F65_02290	COG1476	TRANSCRIPTIONal
A6F65_02296	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6F65_02297	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6F65_02298	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6F65_02299	COG0805	protein transport
A6F65_02300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F65_02301	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6F65_02302	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6F65_02303	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6F65_02304	COG1472	Belongs to the glycosyl hydrolase 3 family
A6F65_02306	COG0018	arginyl-trna synthetase
A6F65_02308	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6F65_02309	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6F65_02310	COG0328	RNA-DNA hybrid ribonuclease activity
A6F65_02311	COG3422	double-strand break repair
A6F65_02316	COG4964	Belongs to the GSP D family
A6F65_02322	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6F65_02331	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6F65_02332	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F65_02335	COG0154	amidase activity
A6F65_02336	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6F65_02339	COG0545	Peptidyl-prolyl cis-trans isomerase
A6F65_02340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6F65_02341	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6F65_02343	COG0546	phosphoglycolate phosphatase activity
A6F65_02348	COG1127	ABC transporter
A6F65_02349	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6F65_02350	COG0525	valine-tRNA ligase activity
A6F65_02352	COG0602	queuosine metabolic process
A6F65_02356	COG0730	response to heat
A6F65_02358	COG1215	transferase activity, transferring glycosyl groups
A6F65_02359	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6F65_02362	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6F65_02363	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6F65_02366	COG0564	pseudouridine synthase activity
A6F65_02367	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6F65_02368	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6F65_02370	COG1595	DNA-templated transcription, initiation
A6F65_02372	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6F65_02376	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6F65_02377	COG0740	serine-type endopeptidase activity
A6F65_02379	COG0154	amidase activity
A6F65_02381	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6F65_02386	COG1160	GTP binding
A6F65_02391	COG2311	Membrane
A6F65_02393	COG1192	Involved in chromosome partitioning
A6F65_02396	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6F65_02397	COG0540	Belongs to the ATCase OTCase family
A6F65_02398	COG0616	signal peptide processing
A6F65_02401	COG0438	transferase activity, transferring glycosyl groups
A6F65_02402	COG0438	transferase activity, transferring glycosyl groups
A6F65_02408	COG3665	Urea carboxylase-associated protein
A6F65_02415	COG4974	Belongs to the 'phage' integrase family
A6F65_02421	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6F65_02427	COG2197	response regulator
A6F65_02430	COG2239	Acts as a magnesium transporter
A6F65_02431	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6F65_02434	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6F65_02436	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6F65_02437	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6F65_02441	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6F65_02446	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6F65_02447	COG0129	dihydroxy-acid dehydratase activity
A6F65_02448	COG0837	glucose binding
A6F65_02449	COG0800	Aldolase
A6F65_02452	COG0037	tRNA processing
A6F65_02459	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6F65_02466	COG4325	translation initiation factor activity
A6F65_02467	COG4325	translation initiation factor activity
A6F65_02472	COG0321	lipoyl(octanoyl) transferase activity
A6F65_02476	COG4774	siderophore transport
A6F65_02477	COG2080	2 iron, 2 sulfur cluster binding
A6F65_02478	COG0534	Mate efflux family protein
A6F65_02479	COG1012	belongs to the aldehyde dehydrogenase family
A6F65_02480	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6F65_02481	COG4149	molybdate abc transporter
A6F65_02482	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6F65_02483	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6F65_02489	COG0745	RESPONSE REGULATOR receiver
A6F65_02490	COG0436	Aminotransferase
A6F65_02491	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6F65_02500	COG0784	Response regulator, receiver
A6F65_02501	COG2202	Pas domain
A6F65_02501	COG3920	Histidine kinase
A6F65_02505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6F65_02507	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6F65_02508	COG0351	phosphomethylpyrimidine kinase
A6F65_02508	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6F65_02508	COG0352	thiamine-phosphate diphosphorylase activity
A6F65_02509	COG1611	Belongs to the LOG family
A6F65_02512	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6F65_02513	COG3474	cytochrome
A6F65_02514	COG0077	Prephenate dehydratase
A6F65_02517	COG0714	Associated with various cellular activities
A6F65_02521	COG0454	-acetyltransferase
A6F65_02523	COG0668	transmembrane transport
A6F65_02527	COG2067	long-chain fatty acid transport protein
A6F65_02528	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6F65_02530	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6F65_02533	COG2989	Protein conserved in bacteria
A6F65_02536	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6F65_02537	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6F65_02540	COG2255	four-way junction helicase activity
A6F65_02541	COG0632	four-way junction helicase activity
A6F65_02542	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6F65_02544	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6F65_02549	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6F65_02550	COG0728	peptidoglycan biosynthetic process
A6F65_02551	COG0180	Tryptophanyl-tRNA synthetase
A6F65_02555	COG0756	dUTP diphosphatase activity
A6F65_02556	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6F65_02560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6F65_02561	COG2226	methyltransferase
A6F65_02562	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6F65_02563	COG0268	Binds directly to 16S ribosomal RNA