locus-tag	class	description
EP12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP12_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP12_00040	COG2818	Glycosylase
EP12_00050	COG3078	GTPase activator activity
EP12_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP12_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP12_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EP12_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP12_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP12_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP12_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP12_00105	COG1652	LysM domain
EP12_00110	COG0758	DNA mediated transformation
EP12_00125	COG0009	L-threonylcarbamoyladenylate synthase
EP12_00130	COG0408	coproporphyrinogen oxidase activity
EP12_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP12_00235	COG2234	aminopeptidase activity
EP12_00240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP12_00260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP12_00285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_00315	COG3642	lipopolysaccharide core region biosynthetic process
EP12_00320	COG0859	PFAM glycosyl transferase family 9
EP12_00340	COG0156	8-amino-7-oxononanoate synthase activity
EP12_00350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_00355	COG0705	Rhomboid family
EP12_00365	COG3161	chorismate lyase activity
EP12_00370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP12_00375	COG2960	long-chain fatty acid transporting porin activity
EP12_00380	COG0210	DNA helicase
EP12_00440	COG1129	ABC transporter
EP12_00440	COG0842	Transport permease protein
EP12_00445	COG0842	Transport permease protein
EP12_00450	COG4773	Receptor
EP12_00455	COG4771	TonB-dependent receptor
EP12_00460	COG1960	acyl-CoA dehydrogenase activity
EP12_00465	COG0583	DNA-binding transcription factor activity
EP12_00475	COG3106	COG3106 Predicted ATPase
EP12_00490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP12_00510	COG0352	thiamine-phosphate diphosphorylase activity
EP12_00520	COG4771	TonB-dependent receptor
EP12_00535	COG0778	Nitroreductase
EP12_00535	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EP12_00555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP12_00570	COG1309	transcriptional regulator
EP12_00600	COG1953	Uracil, thiamine, allantoin
EP12_00615	COG2959	enzyme of heme biosynthesis
EP12_00620	COG1587	Uroporphyrinogen-III synthase
EP12_00625	COG0181	hydroxymethylbilane synthase activity
EP12_00630	COG3706	GGDEF domain
EP12_00630	COG0745	RESPONSE REGULATOR receiver
EP12_00640	COG0194	GDP metabolic process
EP12_00650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP12_00660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP12_00665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP12_00675	COG0678	peroxiredoxin activity
EP12_00695	COG1178	ABC-type Fe3 transport system permease component
EP12_00700	COG3842	ATPase activity
EP12_00705	COG0668	transmembrane transport
EP12_00710	COG2081	HI0933 family
EP12_00720	COG4774	siderophore transport
EP12_00735	COG0745	RESPONSE REGULATOR receiver
EP12_00740	COG0457	Tetratricopeptide repeat
EP12_00765	COG0010	Belongs to the arginase family
EP12_00770	COG0010	Belongs to the arginase family
EP12_00775	COG5002	protein histidine kinase activity
EP12_00775	COG2198	Histidine kinase
EP12_00775	COG0784	Response regulator, receiver
EP12_00790	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP12_00795	COG0411	ABC transporter
EP12_00805	COG0829	nickel cation binding
EP12_00810	COG0831	urea catabolic process
EP12_00830	COG0830	nickel cation binding
EP12_00850	COG3706	GGDEF domain
EP12_00860	COG0583	DNA-binding transcription factor activity
EP12_00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP12_00895	COG0427	acetyl-CoA hydrolase
EP12_00900	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP12_00935	COG5001	Diguanylate cyclase
EP12_00935	COG5002	protein histidine kinase activity
EP12_00950	COG0514	ATP-dependent DNA helicase (RecQ)
EP12_00955	COG2050	protein possibly involved in aromatic compounds catabolism
EP12_00960	COG2239	Acts as a magnesium transporter
EP12_00965	COG2962	Rard protein
EP12_00970	COG3706	GGDEF domain
EP12_00970	COG0745	RESPONSE REGULATOR receiver
EP12_00975	COG0210	DNA helicase
EP12_00985	COG1011	Hydrolase
EP12_01005	COG0019	diaminopimelate decarboxylase activity
EP12_01035	COG0163	prenyltransferase activity
EP12_01040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP12_01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP12_01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP12_01080	COG2814	Major facilitator Superfamily
EP12_01085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_01115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EP12_01150	COG2801	Transposase and inactivated derivatives
EP12_01185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP12_01220	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_01255	COG1077	Cell shape determining protein MreB Mrl
EP12_01260	COG1792	Involved in formation and maintenance of cell shape
EP12_01265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP12_01270	COG0424	maF-like protein
EP12_01275	COG1530	ribonuclease E activity
EP12_01290	COG0312	modulator of DNA gyrase
EP12_01295	COG3028	Belongs to the UPF0307 family
EP12_01300	COG0312	modulator of DNA gyrase
EP12_01315	COG0745	RESPONSE REGULATOR receiver
EP12_01320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_01320	COG4191	Histidine kinase
EP12_01335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP12_01340	COG0148	phosphopyruvate hydratase activity
EP12_01375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP12_01395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EP12_01445	COG4974	Belongs to the 'phage' integrase family
EP12_01510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EP12_01520	COG0463	Glycosyl transferase, family 2
EP12_01530	COG0745	RESPONSE REGULATOR receiver
EP12_01575	COG0789	Transcriptional regulator
EP12_01580	COG2217	Heavy metal translocating P-type atpase
EP12_01620	COG0531	amino acid
EP12_01630	COG2132	Multicopper oxidase
EP12_01735	COG2814	Major facilitator Superfamily
EP12_01740	COG0840	transmembrane signaling receptor activity
EP12_01745	COG0745	RESPONSE REGULATOR receiver
EP12_01750	COG2198	Histidine kinase
EP12_01750	COG0643	Histidine kinase
EP12_01755	COG0835	chemotaxis
EP12_01770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP12_01805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP12_01865	COG4989	oxidoreductase activity
EP12_01870	COG3040	lipid binding
EP12_01885	COG0513	Belongs to the DEAD box helicase family
EP12_01895	COG3590	peptidase
EP12_01900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_01910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP12_01915	COG1132	(ABC) transporter
EP12_01925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_01930	COG0250	Participates in transcription elongation, termination and antitermination
EP12_01945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP12_01950	COG0081	regulation of translation
EP12_01955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP12_01960	COG0222	ribosome binding
EP12_01965	COG0085	RNA polymerase activity
EP12_01970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP12_01975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP12_01980	COG0049	tRNA binding
EP12_02040	COG0051	transcription antitermination factor activity, RNA binding
EP12_02055	COG0089	rRNA binding
EP12_02065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP12_02075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP12_02090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP12_02095	COG0438	transferase activity, transferring glycosyl groups
EP12_02140	COG0788	formyltetrahydrofolate deformylase activity
EP12_02170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP12_02190	COG2169	Transcriptional regulator
EP12_02210	COG0004	ammonium transporteR
EP12_02220	COG0405	Gamma-glutamyltransferase
EP12_02225	COG2837	iron assimilation
EP12_02270	COG3300	MHYT domain
EP12_02270	COG5001	Diguanylate cyclase
EP12_02290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP12_02300	COG0512	Glutamine amidotransferase of anthranilate synthase
EP12_02305	COG0180	Tryptophanyl-tRNA synthetase
EP12_02310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP12_02340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP12_02375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP12_02380	COG0281	malic enzyme
EP12_02390	COG0625	glutathione transferase activity
EP12_02395	COG0753	catalase activity
EP12_02415	COG3300	MHYT domain
EP12_02415	COG5001	Diguanylate cyclase
EP12_02420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP12_02420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP12_02430	COG0137	argininosuccinate synthase activity
EP12_02450	COG1803	Methylglyoxal synthase
EP12_02475	COG0745	RESPONSE REGULATOR receiver
EP12_02485	COG2267	carboxylic ester hydrolase activity
EP12_02490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP12_02500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP12_02510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_02515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_02520	COG4942	peptidase
EP12_02555	COG1162	GTPase activity
EP12_02560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP12_02595	COG0028	Belongs to the TPP enzyme family
EP12_02615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP12_02635	COG3706	GGDEF domain
EP12_02645	COG0248	Ppx GppA phosphatase
EP12_02650	COG0513	Belongs to the DEAD box helicase family
EP12_02655	COG3118	belongs to the thioredoxin family
EP12_02665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP12_02670	COG1473	amidohydrolase
EP12_02680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP12_02690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EP12_02705	COG0783	Belongs to the Dps family
EP12_02725	COG3118	belongs to the thioredoxin family
EP12_02735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP12_02740	COG1012	belongs to the aldehyde dehydrogenase family
EP12_02750	COG1757	Na H antiporter
EP12_02765	COG3876	Protein conserved in bacteria
EP12_02875	COG0519	Catalyzes the synthesis of GMP from XMP
EP12_02920	COG1228	amidohydrolase
EP12_02955	COG0183	Belongs to the thiolase family
EP12_02960	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_02960	COG1024	Enoyl-CoA hydratase
EP12_02975	COG0006	proline dipeptidase activity
EP12_02985	COG0142	geranyltranstransferase activity
EP12_03035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP12_03040	COG1388	LysM domain
EP12_03040	COG4942	peptidase
EP12_03045	COG1238	metal cluster binding
EP12_03055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP12_03060	COG0585	pseudouridine synthase activity
EP12_03075	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP12_03085	COG0840	transmembrane signaling receptor activity
EP12_03095	COG1538	Outer membrane efflux protein
EP12_03115	COG2770	Histidine kinase
EP12_03115	COG2205	protein histidine kinase activity
EP12_03140	COG0494	nUDIX hydrolase
EP12_03150	COG0730	response to heat
EP12_03155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP12_03175	COG0784	Response regulator, receiver
EP12_03175	COG2205	protein histidine kinase activity
EP12_03195	COG0564	pseudouridine synthase activity
EP12_03220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP12_03220	COG1648	precorrin-2 dehydrogenase activity
EP12_03245	COG1538	Outer membrane efflux protein
EP12_03250	COG0494	nUDIX hydrolase
EP12_03255	COG3151	Protein conserved in bacteria
EP12_03265	COG3150	esterase
EP12_03280	COG4251	negative regulation of phosphorylation
EP12_03285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_03305	COG1509	lysine 2,3-aminomutase activity
EP12_03330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP12_03345	COG0271	Belongs to the BolA IbaG family
EP12_03355	COG3707	response regulator
EP12_03365	COG0659	secondary active sulfate transmembrane transporter activity
EP12_03370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP12_03375	COG2146	nitrite reductase [NAD(P)H] activity
EP12_03380	COG0243	molybdopterin cofactor binding
EP12_03385	COG1648	precorrin-2 dehydrogenase activity
EP12_03385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP12_03390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP12_03405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP12_03405	COG1116	anion transmembrane transporter activity
EP12_03410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP12_03415	COG1116	anion transmembrane transporter activity
EP12_03425	COG0746	molybdenum cofactor guanylyltransferase activity
EP12_03435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP12_03440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP12_03445	COG0348	domain, Protein
EP12_03465	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_03475	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_03495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_03530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP12_03535	COG0358	DNA primase activity
EP12_03555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP12_03575	COG0537	adenosine 5'-monophosphoramidase activity
EP12_03590	COG3135	benzoate transporter
EP12_03595	COG1396	sequence-specific DNA binding
EP12_03605	COG4191	Histidine kinase
EP12_03605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_03610	COG0745	RESPONSE REGULATOR receiver
EP12_03615	COG5002	protein histidine kinase activity
EP12_03645	COG0811	peptide transport
EP12_03650	COG0811	peptide transport
EP12_03655	COG0848	biopolymer transport protein
EP12_03670	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP12_03680	COG2205	protein histidine kinase activity
EP12_03680	COG5002	protein histidine kinase activity
EP12_03680	COG0784	Response regulator, receiver
EP12_03685	COG0318	PFAM AMP-dependent synthetase and ligase
EP12_03700	COG1049	propionate catabolic process, 2-methylcitrate cycle
EP12_03725	COG0527	aspartate kinase activity
EP12_03730	COG0840	transmembrane signaling receptor activity
EP12_03740	COG2967	ApaG domain
EP12_03745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP12_03750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP12_03755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_03760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP12_03770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EP12_03780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP12_03800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP12_03815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP12_03820	COG3956	TIGRFAM MazG family protein
EP12_03835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP12_03840	COG1595	DNA-templated transcription, initiation
EP12_03850	COG4206	TonB-dependent receptor
EP12_03860	COG0723	plastoquinol--plastocyanin reductase activity
EP12_03865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP12_03870	COG2857	Cytochrome c1
EP12_03875	COG0625	glutathione transferase activity
EP12_03880	COG2969	positive regulation of protein catabolic process
EP12_03895	COG0745	RESPONSE REGULATOR receiver
EP12_03900	COG2239	Acts as a magnesium transporter
EP12_03905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP12_03915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP12_03925	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EP12_03930	COG1137	ATPase activity
EP12_03945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP12_03960	COG1127	ABC transporter
EP12_03965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP12_03970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP12_03975	COG2854	intermembrane phospholipid transfer
EP12_03985	COG5007	Belongs to the BolA IbaG family
EP12_03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP12_04005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP12_04020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EP12_04075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_04085	COG2205	protein histidine kinase activity
EP12_04085	COG0784	Response regulator, receiver
EP12_04100	COG1979	alcohol dehydrogenase
EP12_04125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP12_04135	COG0126	phosphoglycerate kinase activity
EP12_04140	COG3588	fructose-bisphosphate aldolase
EP12_04145	COG0248	Ppx GppA phosphatase
EP12_04150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP12_04160	COG0573	inorganic phosphate transmembrane transporter activity
EP12_04170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP12_04180	COG0306	phosphate transporter
EP12_04185	COG0589	response to stress
EP12_04190	COG0583	DNA-binding transcription factor activity
EP12_04200	COG1272	protein, Hemolysin III
EP12_04205	COG1846	Transcriptional regulator
EP12_04210	COG1764	response to oxidative stress
EP12_04220	COG1739	Uncharacterized protein family UPF0029
EP12_04235	COG0419	ATPase involved in DNA repair
EP12_04240	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EP12_04250	COG1073	alpha beta
EP12_04255	COG2207	Transcriptional regulator
EP12_04260	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EP12_04275	COG0625	glutathione transferase activity
EP12_04320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP12_04370	COG2897	thiosulfate sulfurtransferase activity
EP12_04375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP12_04430	COG1346	cytolysis
EP12_04460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP12_04465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP12_04470	COG0513	Belongs to the DEAD box helicase family
EP12_04480	COG3267	Type II secretory pathway component ExeA
EP12_04480	COG3409	Peptidoglycan-binding domain 1 protein
EP12_04495	COG0066	3-isopropylmalate dehydratase activity
EP12_04505	COG0473	3-isopropylmalate dehydrogenase activity
EP12_04510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP12_04560	COG4555	ABC transporter
EP12_04565	COG1668	transmembrane transport
EP12_04580	COG4133	protoheme IX ABC transporter activity
EP12_04585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_04590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_04595	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP12_04605	COG1138	Cytochrome C-type biogenesis protein
EP12_04610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP12_04630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP12_04670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP12_04675	COG1216	Glycosyl transferase, family 2
EP12_04675	COG0463	Glycosyl transferase, family 2
EP12_04685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP12_04690	COG1555	photosystem II stabilization
EP12_04690	COG1596	polysaccharide export
EP12_04695	COG0473	3-isopropylmalate dehydrogenase activity
EP12_04710	COG1611	Belongs to the LOG family
EP12_04715	COG0745	RESPONSE REGULATOR receiver
EP12_04715	COG3706	GGDEF domain
EP12_04720	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP12_04720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP12_04745	COG3209	COG3209 Rhs family protein
EP12_04805	COG0564	pseudouridine synthase activity
EP12_04820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP12_04825	COG0024	Methionine aminopeptidase
EP12_04830	COG0052	Belongs to the universal ribosomal protein uS2 family
EP12_04840	COG0528	UMP kinase activity
EP12_04850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP12_04855	COG0575	Belongs to the CDS family
EP12_04880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP12_04905	COG0825	malonyl-CoA metabolic process
EP12_04930	COG0590	tRNA wobble adenosine to inosine editing
EP12_04940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP12_04940	COG0047	phosphoribosylformylglycinamidine synthase activity
EP12_04950	COG2840	Smr protein MutS2
EP12_04985	COG0784	Response regulator, receiver
EP12_04985	COG0835	chemotaxis
EP12_04990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP12_04995	COG1815	bacterial-type flagellum-dependent cell motility
EP12_05000	COG1558	bacterial-type flagellum-dependent cell motility
EP12_05010	COG1749	Flagellar hook protein flgE
EP12_05015	COG4787	bacterial-type flagellum-dependent cell motility
EP12_05020	COG4786	Flagellar basal body rod
EP12_05035	COG1705	Flagellar rod assembly protein muramidase FlgJ
EP12_05035	COG3951	Flagellar rod assembly protein muramidase FlgJ
EP12_05040	COG1256	bacterial-type flagellum assembly
EP12_05060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP12_05085	COG1516	flagellar protein fliS
EP12_05095	COG1086	Polysaccharide biosynthesis protein
EP12_05100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP12_05105	COG1083	cytidylyl-transferase
EP12_05110	COG2089	acid synthase
EP12_05130	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_05185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP12_05195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_05205	COG3475	LICD family
EP12_05210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP12_05250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP12_05265	COG2204	response regulator
EP12_05270	COG3852	Histidine kinase
EP12_05275	COG2204	response regulator
EP12_05280	COG1677	Flagellar hook-basal body complex protein FliE
EP12_05285	COG1766	The M ring may be actively involved in energy transduction
EP12_05290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP12_05355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP12_05365	COG0455	bacterial-type flagellum organization
EP12_05380	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EP12_05385	COG2198	Histidine kinase
EP12_05385	COG0643	Histidine kinase
EP12_05395	COG1192	Involved in chromosome partitioning
EP12_05405	COG0835	chemotaxis
EP12_05435	COG3123	guanosine phosphorylase activity
EP12_05440	COG0583	DNA-binding transcription factor activity
EP12_05445	COG0583	DNA-binding transcription factor activity
EP12_05450	COG0288	reversible hydration of carbon dioxide
EP12_05470	COG2137	regulation of response to DNA damage stimulus
EP12_05475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP12_05510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EP12_05520	COG4172	Belongs to the ABC transporter superfamily
EP12_05525	COG4171	peptide transport system, permease
EP12_05530	COG0601	transmembrane transport
EP12_05535	COG0747	negative chemotaxis
EP12_05540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EP12_05545	COG1842	Phage shock protein A
EP12_05575	COG0625	glutathione transferase activity
EP12_05580	COG1522	sequence-specific DNA binding
EP12_05620	COG0811	peptide transport
EP12_05625	COG0811	peptide transport
EP12_05650	COG1444	tRNA N-acetyltransferase activity
EP12_05690	COG0456	acetyltransferase
EP12_05715	COG0656	L-ascorbic acid biosynthetic process
EP12_05765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP12_05785	COG0633	Ferredoxin
EP12_05785	COG0543	2 iron, 2 sulfur cluster binding
EP12_05795	COG3547	Transposase (IS116 IS110 IS902 family)
EP12_05885	COG2918	glutathione biosynthetic process
EP12_05900	COG1136	(ABC) transporter
EP12_05930	COG2840	Smr protein MutS2
EP12_05935	COG2890	protein-(glutamine-N5) methyltransferase activity
EP12_05955	COG2719	SpoVR family
EP12_05975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP12_06015	COG0584	glycerophosphoryl diester phosphodiesterase
EP12_06020	COG0346	lactoylglutathione lyase activity
EP12_06025	COG1278	Cold shock
EP12_06035	COG3706	GGDEF domain
EP12_06040	COG3710	Transcriptional regulator
EP12_06135	COG4660	Part of a membrane complex involved in electron transport
EP12_06140	COG4659	FMN binding
EP12_06145	COG4658	electron transport chain
EP12_06155	COG2878	Part of a membrane complex involved in electron transport
EP12_06160	COG4657	Part of a membrane complex involved in electron transport
EP12_06175	COG0534	Mate efflux family protein
EP12_06180	COG0556	nucleotide-excision repair
EP12_06205	COG0602	queuosine metabolic process
EP12_06215	COG0367	asparagine synthase
EP12_06240	COG0471	metal ion transport
EP12_06240	COG3273	potassium ion transport
EP12_06255	COG0529	Catalyzes the synthesis of activated sulfate
EP12_06260	COG0175	sulfate reduction
EP12_06265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_06280	COG1595	DNA-templated transcription, initiation
EP12_06295	COG2304	oxidoreductase activity
EP12_06315	COG0714	Associated with various cellular activities
EP12_06325	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_06325	COG1024	Enoyl-CoA hydratase
EP12_06350	COG1025	Belongs to the peptidase M16 family
EP12_06355	COG2062	phosphohistidine phosphatase, SixA
EP12_06365	COG4536	flavin adenine dinucleotide binding
EP12_06370	COG4137	Cytochrome C assembly protein
EP12_06380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP12_06425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP12_06430	COG1132	(ABC) transporter
EP12_06450	COG0228	four-way junction DNA binding
EP12_06455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP12_06460	COG0336	Belongs to the RNA methyltransferase TrmD family
EP12_06465	COG0335	large ribosomal subunit rRNA binding
EP12_06470	COG2860	membrane
EP12_06480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP12_06485	COG0287	Prephenate dehydrogenase
EP12_06485	COG1605	Chorismate mutase
EP12_06490	COG1605	Chorismate mutase
EP12_06490	COG0077	Prephenate dehydratase
EP12_06500	COG0745	RESPONSE REGULATOR receiver
EP12_06505	COG0023	Translation Initiation Factor
EP12_06535	COG2205	protein histidine kinase activity
EP12_06545	COG2204	response regulator
EP12_06550	COG1801	Protein of unknown function DUF72
EP12_06555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP12_06560	COG0494	nUDIX hydrolase
EP12_06575	COG2255	four-way junction helicase activity
EP12_06580	COG0824	Thioesterase
EP12_06585	COG0811	peptide transport
EP12_06605	COG2885	chlorophyll binding
EP12_06610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EP12_06630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP12_06730	COG4387	Mu-like prophage protein GP36
EP12_06740	COG4397	Mu-like prophage major head subunit gpT
EP12_06775	COG4383	Mu-like prophage protein gp29
EP12_06780	COG4373	Mu-like prophage FluMu protein gp28
EP12_06925	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_06955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_06965	COG0612	Peptidase, M16
EP12_06990	COG4221	oxidoreductase activity
EP12_06995	COG0753	catalase activity
EP12_07000	COG3038	cytochrome b561
EP12_07005	COG0583	DNA-binding transcription factor activity
EP12_07055	COG3008	intermembrane lipid transfer
EP12_07055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP12_07060	COG2995	paraquat-inducible protein a
EP12_07085	COG3093	addiction module antidote protein HigA
EP12_07105	COG0017	Asparaginyl-tRNA synthetase
EP12_07120	COG0189	ligase activity
EP12_07165	COG3340	Belongs to the peptidase S51 family
EP12_07170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP12_07175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EP12_07185	COG1131	(ABC) transporter
EP12_07200	COG3279	Response regulator of the LytR AlgR family
EP12_07210	COG5265	(ABC) transporter
EP12_07215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP12_07280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP12_07285	COG0402	S-adenosylhomocysteine deaminase activity
EP12_07305	COG2755	lipolytic protein G-D-S-L family
EP12_07310	COG4181	ATPase activity
EP12_07320	COG1090	epimerase
EP12_07325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EP12_07330	COG0628	permease
EP12_07335	COG2205	protein histidine kinase activity
EP12_07340	COG0745	RESPONSE REGULATOR receiver
EP12_07355	COG2350	Protein conserved in bacteria
EP12_07370	COG0135	phosphoribosylanthranilate isomerase activity
EP12_07370	COG0134	indole-3-glycerol-phosphate synthase activity
EP12_07385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP12_07390	COG0613	PHP domain protein
EP12_07395	COG0009	L-threonylcarbamoyladenylate synthase
EP12_07400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP12_07405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP12_07415	COG0656	L-ascorbic acid biosynthetic process
EP12_07420	COG0110	maltose O-acetyltransferase activity
EP12_07435	COG2733	membrane
EP12_07440	COG0500	methyltransferase
EP12_07445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_07460	COG0783	Belongs to the Dps family
EP12_07470	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_07490	COG4771	TonB-dependent receptor
EP12_07510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP12_07520	COG0484	heat shock protein binding
EP12_07525	COG3909	cytochrome
EP12_07530	COG5001	Diguanylate cyclase
EP12_07530	COG3300	MHYT domain
EP12_07540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP12_07550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP12_07555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP12_07570	COG0071	Belongs to the small heat shock protein (HSP20) family
EP12_07575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EP12_07585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP12_07590	COG4535	Mg2 and Co2 transporter CorC
EP12_07595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP12_07615	COG1702	phosphate starvation-inducible protein PhoH
EP12_07625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_07655	COG1607	acyl-coa hydrolase
EP12_07660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP12_07665	COG1115	amino acid carrier protein
EP12_07760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP12_07765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP12_07780	COG2890	protein-(glutamine-N5) methyltransferase activity
EP12_07785	COG3437	response regulator, receiver
EP12_07785	COG0784	Response regulator, receiver
EP12_07790	COG3094	Invasion gene expression up-regulator, SirB
EP12_07805	COG0583	DNA-binding transcription factor activity
EP12_07815	COG2363	Small membrane protein
EP12_07835	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EP12_07840	COG0515	serine threonine protein kinase
EP12_07840	COG2815	serine threonine protein kinase
EP12_07850	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EP12_07855	COG0033	Phosphoglucomutase
EP12_07860	COG0058	SHG alpha-glucan phosphorylase activity
EP12_07870	COG2988	succinylglutamate desuccinylase activity
EP12_07900	COG1393	Belongs to the ArsC family
EP12_08025	COG5002	protein histidine kinase activity
EP12_08025	COG5001	Diguanylate cyclase
EP12_08025	COG3447	MASE1 domain protein
EP12_08040	COG2351	hydroxyisourate hydrolase activity
EP12_08055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP12_08080	COG2252	PERMEase
EP12_08095	COG3300	MHYT domain
EP12_08095	COG5001	Diguanylate cyclase
EP12_08105	COG0784	Response regulator, receiver
EP12_08105	COG2205	protein histidine kinase activity
EP12_08155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_08160	COG0730	response to heat
EP12_08200	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_08215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP12_08235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP12_08245	COG1596	polysaccharide export
EP12_08255	COG4464	protein tyrosine phosphatase activity
EP12_08310	COG2755	lipolytic protein G-D-S-L family
EP12_08310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP12_08360	COG0072	phenylalanine-tRNA ligase activity
EP12_08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_08390	COG2096	Adenosyltransferase
EP12_08400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP12_08410	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP12_08415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP12_08425	COG0708	Exodeoxyribonuclease III
EP12_08460	COG2814	Major facilitator Superfamily
EP12_08500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP12_08510	COG0789	Transcriptional regulator
EP12_08515	COG0183	Belongs to the thiolase family
EP12_08530	COG2925	Exonuclease
EP12_08590	COG0604	alcohol dehydrogenase
EP12_08590	COG3321	synthase
EP12_08595	COG0328	RNA-DNA hybrid ribonuclease activity
EP12_08600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP12_08640	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP12_08655	COG3724	N-succinylarginine dihydrolase activity
EP12_08665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP12_08670	COG3122	Protein conserved in bacteria
EP12_08675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP12_08680	COG2153	protein acetylation
EP12_08700	COG0564	pseudouridine synthase activity
EP12_08715	COG1399	metal-binding, possibly nucleic acid-binding protein
EP12_08745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP12_08750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP12_08760	COG0596	Alpha beta hydrolase
EP12_08775	COG1960	acyl-CoA dehydrogenase activity
EP12_08785	COG2390	Transcriptional regulator
EP12_08790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_08825	COG0668	transmembrane transport
EP12_08830	COG4771	TonB-dependent receptor
EP12_08860	COG3437	response regulator, receiver
EP12_08870	COG0195	Participates in both transcription termination and antitermination
EP12_08885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP12_08910	COG3153	acetyltransferase
EP12_08910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP12_08940	COG0450	alkyl hydroperoxide reductase
EP12_08980	COG1032	radical SAM domain protein
EP12_08995	COG4771	TonB-dependent receptor
EP12_09000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_09010	COG4134	Bacterial extracellular solute-binding protein
EP12_09020	COG4136	ATPase activity
EP12_09025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP12_09035	COG3932	Exopolysaccharide synthesis, ExoD
EP12_09075	COG0840	transmembrane signaling receptor activity
EP12_09095	COG1131	(ABC) transporter
EP12_09125	COG2867	negative regulation of translational initiation
EP12_09130	COG2914	Belongs to the UPF0125 (RnfH) family
EP12_09140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP12_09145	COG4771	TonB-dependent receptor
EP12_09150	COG0457	Tetratricopeptide repeat
EP12_09180	COG0247	lactate metabolic process
EP12_09180	COG0277	FAD linked oxidase domain protein
EP12_09190	COG2850	peptidyl-arginine hydroxylation
EP12_09200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP12_09205	COG2915	High frequency lysogenization protein hflD homolog
EP12_09210	COG0482	sulfurtransferase activity
EP12_09215	COG1187	pseudouridine synthase activity
EP12_09225	COG1278	Cold shock
EP12_09230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP12_09235	COG0542	response to heat
EP12_09240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP12_09245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EP12_09250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP12_09255	COG0492	ferredoxin-NADP+ reductase activity
EP12_09260	COG3092	negative regulation of chromosome organization
EP12_09265	COG3091	SprT-like family
EP12_09270	COG0616	signal peptide processing
EP12_09280	COG0778	Nitroreductase
EP12_09290	COG0252	asparaginase activity
EP12_09295	COG3706	GGDEF domain
EP12_09300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP12_09305	COG0321	lipoyl(octanoyl) transferase activity
EP12_09310	COG2921	Belongs to the UPF0250 family
EP12_09315	COG1686	Belongs to the peptidase S11 family
EP12_09320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP12_09325	COG0772	Belongs to the SEDS family
EP12_09330	COG0768	penicillin binding
EP12_09335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP12_09340	COG0799	negative regulation of ribosome biogenesis
EP12_09345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP12_09350	COG1466	dna polymerase III delta subunit
EP12_09355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EP12_09360	COG0495	leucyl-tRNA aminoacylation
EP12_09365	COG1067	ATP-dependent peptidase activity
EP12_09375	COG1534	Rna-binding protein
EP12_09380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP12_09385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP12_09390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP12_09395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP12_09400	COG0149	triose-phosphate isomerase activity
EP12_09405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_09430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EP12_09445	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_09460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_09490	COG1185	polyribonucleotide nucleotidyltransferase activity
EP12_09515	COG0295	cytidine deaminase activity
EP12_09530	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EP12_09535	COG1196	nuclear chromosome segregation
EP12_09545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP12_09560	COG1132	(ABC) transporter
EP12_09645	COG2808	Putative FMN-binding domain
EP12_09685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP12_09710	COG2009	succinate dehydrogenase
EP12_09715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EP12_09720	COG1053	succinate dehydrogenase
EP12_09725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP12_09730	COG0567	Dehydrogenase, E1 component
EP12_09735	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP12_09790	COG0366	Alpha amylase catalytic
EP12_09815	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_09820	COG2267	carboxylic ester hydrolase activity
EP12_09830	COG0616	signal peptide processing
EP12_09845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP12_09855	COG0386	Belongs to the glutathione peroxidase family
EP12_09860	COG2084	Dehydrogenase
EP12_09875	COG1960	acyl-CoA dehydrogenase activity
EP12_09890	COG2226	methyltransferase
EP12_09895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP12_09900	COG3083	sulfuric ester hydrolase activity
EP12_09905	COG3082	Protein of unknown function (DUF1414)
EP12_09910	COG3081	Nucleoid-associated protein
EP12_09940	COG3275	phosphorelay sensor kinase activity
EP12_09945	COG3279	Response regulator of the LytR AlgR family
EP12_09950	COG0205	6-phosphofructokinase activity
EP12_09980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP12_10005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_10030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP12_10065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_10065	COG2205	protein histidine kinase activity
EP12_10100	COG0513	Belongs to the DEAD box helicase family
EP12_10110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP12_10145	COG1760	l-serine dehydratase
EP12_10165	COG1322	Protein conserved in bacteria
EP12_10170	COG3706	GGDEF domain
EP12_10190	COG1404	Belongs to the peptidase S8 family
EP12_10200	COG0022	dehydrogenase e1 component
EP12_10210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP12_10215	COG0515	serine threonine protein kinase
EP12_10220	COG1946	Acyl-CoA thioesterase
EP12_10230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP12_10240	COG1956	GAF domain-containing protein
EP12_10255	COG0793	Belongs to the peptidase S41A family
EP12_10260	COG0733	neurotransmitter:sodium symporter activity
EP12_10315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_10360	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_10405	COG0309	Hydrogenase expression formation protein (HypE)
EP12_10410	COG0789	Transcriptional regulator
EP12_10415	COG2217	Heavy metal translocating P-type atpase
EP12_10460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_10475	COG3667	copper resistance
EP12_10480	COG2132	Multicopper oxidase
EP12_10505	COG4977	sequence-specific DNA binding
EP12_10510	COG0789	Transcriptional regulator
EP12_10560	COG4772	TonB-dependent receptor
EP12_10625	COG2801	Transposase and inactivated derivatives
EP12_10680	COG5002	protein histidine kinase activity
EP12_10685	COG0745	RESPONSE REGULATOR receiver
EP12_10715	COG0167	dihydroorotate dehydrogenase activity
EP12_10740	COG3130	regulation of translation
EP12_10745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP12_10755	COG0415	Belongs to the DNA photolyase family
EP12_10765	COG0415	Belongs to the DNA photolyase family
EP12_10770	COG3046	protein related to deoxyribodipyrimidine photolyase
EP12_10790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP12_10795	COG0589	response to stress
EP12_10820	COG2193	ferroxidase activity
EP12_10830	COG3278	Belongs to the heme-copper respiratory oxidase family
EP12_10845	COG2010	Cytochrome c
EP12_10870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP12_10875	COG0589	response to stress
EP12_10880	COG0037	tRNA processing
EP12_10885	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP12_10905	COG1280	lysine exporter protein (LysE YggA)
EP12_10910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP12_10915	COG2897	thiosulfate sulfurtransferase activity
EP12_10920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP12_10980	COG0582	viral genome integration into host DNA
EP12_11005	COG0322	excinuclease ABC activity
EP12_11010	COG2197	response regulator
EP12_11015	COG1741	Belongs to the pirin family
EP12_11035	COG3384	dioxygenase
EP12_11040	COG2259	Doxx family
EP12_11045	COG0583	DNA-binding transcription factor activity
EP12_11060	COG0670	Belongs to the BI1 family
EP12_11065	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP12_11080	COG2920	part of a sulfur-relay system
EP12_11085	COG0561	phosphatase activity
EP12_11115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP12_11120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP12_11125	COG0531	amino acid
EP12_11125	COG1674	ftsk spoiiie
EP12_11135	COG0686	Belongs to the AlaDH PNT family
EP12_11140	COG0284	orotidine-5'-phosphate decarboxylase activity
EP12_11145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EP12_11160	COG0776	regulation of translation
EP12_11165	COG0539	negative regulation of cytoplasmic translation
EP12_11170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP12_11175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP12_11180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP12_11200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP12_11205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP12_11210	COG0633	Ferredoxin
EP12_11250	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EP12_11255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP12_11265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP12_11275	COG4783	chaperone-mediated protein folding
EP12_11280	COG4232	protein-disulfide reductase activity
EP12_11330	COG0024	Methionine aminopeptidase
EP12_11350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP12_11400	COG3769	mannosylglycerate metabolic process
EP12_11405	COG1215	transferase activity, transferring glycosyl groups
EP12_11420	COG0303	'Molybdopterin
EP12_11425	COG0534	Mate efflux family protein
EP12_11445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP12_11460	COG2801	Transposase and inactivated derivatives
EP12_11465	COG2963	transposase activity
EP12_11475	COG0405	Gamma-glutamyltransferase
EP12_11480	COG1024	Enoyl-CoA hydratase
EP12_11520	COG1448	Aminotransferase
EP12_11540	COG1671	Belongs to the UPF0178 family
EP12_11545	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_11550	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_11555	COG1960	acyl-CoA dehydrogenase activity
EP12_11560	COG4977	sequence-specific DNA binding
EP12_11620	COG0596	Alpha beta hydrolase
EP12_11630	COG0716	FMN binding
EP12_11640	COG0735	belongs to the Fur family
EP12_11650	COG1984	allophanate hydrolase subunit 2
EP12_11660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EP12_11665	COG2996	Protein conserved in bacteria
EP12_11670	COG1765	OsmC-like protein
EP12_11690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EP12_11695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP12_11710	COG4771	TonB-dependent receptor
EP12_11715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EP12_11725	COG1238	metal cluster binding
EP12_11735	COG3012	SEC-C Motif Domain Protein
EP12_11750	COG0456	acetyltransferase
EP12_11755	COG3706	GGDEF domain
EP12_11760	COG0702	epimerase
EP12_11770	COG0084	hydrolase, TatD family'
EP12_11785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP12_11835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP12_11860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP12_11865	COG0315	cyclic pyranopterin monophosphate synthase activity
EP12_11870	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP12_11875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP12_11895	COG0436	Aminotransferase
EP12_11900	COG3268	Saccharopine dehydrogenase
EP12_11905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP12_11930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP12_11940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EP12_11955	COG1022	Amp-dependent synthetase and ligase
EP12_11970	COG3132	Protein of unknown function, DUF480
EP12_11985	COG0583	DNA-binding transcription factor activity
EP12_12000	COG3085	chromosome segregation
EP12_12010	COG0640	Transcriptional regulator
EP12_12030	COG2204	response regulator
EP12_12040	COG4251	negative regulation of phosphorylation
EP12_12045	COG0784	Response regulator, receiver
EP12_12095	COG3139	Protein of unknown function (DUF1315)
EP12_12105	COG1115	amino acid carrier protein
EP12_12135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP12_12150	COG1640	4-alpha-glucanotransferase
EP12_12160	COG0676	glucose-6-phosphate 1-epimerase activity
EP12_12170	COG0800	Aldolase
EP12_12175	COG0837	glucose binding
EP12_12180	COG0129	dihydroxy-acid dehydratase activity
EP12_12190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP12_12195	COG1737	Transcriptional regulator
EP12_12200	COG0469	pyruvate kinase activity
EP12_12205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP12_12245	COG2205	protein histidine kinase activity
EP12_12250	COG0745	RESPONSE REGULATOR receiver
EP12_12275	COG3665	Urea carboxylase-associated protein
EP12_12290	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EP12_12315	COG2721	sulfolactate sulfo-lyase activity
EP12_12320	COG1904	glucuronate isomerase
EP12_12325	COG0246	Mannitol dehydrogenase
EP12_12330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_12335	COG2755	lipolytic protein G-D-S-L family
EP12_12345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP12_12355	COG4677	pectinesterase activity
EP12_12375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_12390	COG1119	ATPase activity
EP12_12405	COG1609	Transcriptional regulator
EP12_12410	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_12430	COG5001	Diguanylate cyclase
EP12_12430	COG3300	MHYT domain
EP12_12455	COG0745	RESPONSE REGULATOR receiver
EP12_12460	COG2205	protein histidine kinase activity
EP12_12470	COG0784	Response regulator, receiver
EP12_12470	COG3437	response regulator, receiver
EP12_12480	COG0471	metal ion transport
EP12_12490	COG0489	protein tyrosine kinase activity
EP12_12495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_12495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP12_12500	COG2226	methyltransferase
EP12_12505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_12525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP12_12535	COG1785	Belongs to the alkaline phosphatase family
EP12_12540	COG1785	Belongs to the alkaline phosphatase family
EP12_12565	COG0583	DNA-binding transcription factor activity
EP12_12570	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EP12_12585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EP12_12590	COG1286	toxin biosynthetic process
EP12_12595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EP12_12600	COG0285	dihydrofolate synthase activity
EP12_12635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP12_12730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP12_12740	COG4399	Belongs to the UPF0754 family
EP12_12770	COG2186	Transcriptional regulator
EP12_12780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EP12_12785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP12_12790	COG2983	Belongs to the UPF0260 family
EP12_12795	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP12_12810	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP12_12815	COG0318	PFAM AMP-dependent synthetase and ligase
EP12_12820	COG2267	carboxylic ester hydrolase activity
EP12_12835	COG1214	PFAM Peptidase M22, glycoprotease
EP12_12840	COG1199	ATP-dependent helicase activity
EP12_12885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP12_12900	COG0131	Imidazoleglycerol-phosphate dehydratase
EP12_12900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP12_12920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP12_12920	COG0140	phosphoribosyl-ATP diphosphatase activity
EP12_12965	COG0326	Molecular chaperone. Has ATPase activity
EP12_12970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP12_12990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP12_12995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP12_13005	COG3220	belongs to the UPF0276 family
EP12_13015	COG4249	Peptidase C14 caspase catalytic subunit p20
EP12_13015	COG2319	Wd-40 repeat
EP12_13025	COG3706	GGDEF domain
EP12_13025	COG2203	Gaf domain
EP12_13025	COG4251	negative regulation of phosphorylation
EP12_13025	COG5001	Diguanylate cyclase
EP12_13070	COG0542	response to heat
EP12_13080	COG0564	pseudouridine synthase activity
EP12_13095	COG1595	DNA-templated transcription, initiation
EP12_13110	COG4221	oxidoreductase activity
EP12_13135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP12_13145	COG0142	geranyltranstransferase activity
EP12_13155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP12_13170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP12_13185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP12_13185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP12_13200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP12_13215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP12_13225	COG0560	Phosphoserine phosphatase
EP12_13235	COG0084	hydrolase, TatD family'
EP12_13255	COG0681	Belongs to the peptidase S26 family
EP12_13280	COG1595	DNA-templated transcription, initiation
EP12_13300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EP12_13380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP12_13385	COG1047	Peptidyl-prolyl cis-trans
EP12_13400	COG0196	riboflavin kinase activity
EP12_13405	COG0728	peptidoglycan biosynthetic process
EP12_13410	COG0268	Binds directly to 16S ribosomal RNA
EP12_13440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_13445	COG0776	regulation of translation
EP12_13450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP12_13455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP12_13460	COG0740	serine-type endopeptidase activity
EP12_13465	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP12_13505	COG1720	tRNA m6t6A37 methyltransferase activity
EP12_13525	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP12_13540	COG0516	GMP reductase activity
EP12_13540	COG0517	IMP dehydrogenase activity
EP12_13545	COG1570	exodeoxyribonuclease VII activity
EP12_13560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP12_13565	COG2976	Protein conserved in bacteria
EP12_13590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP12_13600	COG2166	iron-sulfur cluster assembly
EP12_13615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP12_13620	COG0719	Fe-S assembly protein
EP12_13625	COG0396	ATPase activity
EP12_13635	COG1104	cysteine desulfurase activity
EP12_13645	COG1045	serine acetyltransferase
EP12_13650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EP12_13655	COG0483	inositol monophosphate 1-phosphatase activity
EP12_13670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_13675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP12_13680	COG1862	Preprotein translocase
EP12_13685	COG0343	queuine tRNA-ribosyltransferase activity
EP12_13705	COG1842	Phage shock protein A
EP12_13710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP12_13730	COG0754	glutathionylspermidine amidase activity
EP12_13745	COG2066	Belongs to the glutaminase family
EP12_13750	COG1785	Belongs to the alkaline phosphatase family
EP12_13820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP12_13855	COG0367	asparagine synthase
EP12_13865	COG0438	transferase activity, transferring glycosyl groups
EP12_13900	COG1215	transferase activity, transferring glycosyl groups
EP12_13925	COG0438	transferase activity, transferring glycosyl groups
EP12_13930	COG0438	transferase activity, transferring glycosyl groups
EP12_13965	COG0489	protein tyrosine kinase activity
EP12_13975	COG3267	Type II secretory pathway component ExeA
EP12_13975	COG3409	Peptidoglycan-binding domain 1 protein
EP12_13985	COG2827	Endonuclease containing a URI domain
EP12_14005	COG1560	Kdo2-lipid A biosynthetic process
EP12_14015	COG1960	acyl-CoA dehydrogenase activity
EP12_14035	COG1435	thymidine kinase activity
EP12_14040	COG1609	Transcriptional regulator
EP12_14045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP12_14080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EP12_14085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP12_14115	COG1024	Enoyl-CoA hydratase
EP12_14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP12_14130	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EP12_14175	COG2080	2 iron, 2 sulfur cluster binding
EP12_14180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EP12_14185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP12_14205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP12_14250	COG0693	protein deglycase activity
EP12_14265	COG0583	DNA-binding transcription factor activity
EP12_14275	COG0402	S-adenosylhomocysteine deaminase activity
EP12_14285	COG1595	DNA-templated transcription, initiation
EP12_14330	COG1295	ribonuclease BN
EP12_14335	COG2197	response regulator
EP12_14405	COG4681	YaeQ
EP12_14415	COG0477	Major facilitator Superfamily
EP12_14425	COG2207	Transcriptional regulator
EP12_14425	COG1609	Transcriptional regulator
EP12_14440	COG2211	Major facilitator Superfamily
EP12_14460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP12_14465	COG2115	Belongs to the xylose isomerase family
EP12_14480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EP12_14520	COG0514	ATP-dependent DNA helicase (RecQ)
EP12_14525	COG2267	carboxylic ester hydrolase activity
EP12_14545	COG2205	protein histidine kinase activity
EP12_14545	COG5002	protein histidine kinase activity
EP12_14545	COG0784	Response regulator, receiver
EP12_14550	COG1595	DNA-templated transcription, initiation
EP12_14560	COG1764	response to oxidative stress
EP12_14565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP12_14570	COG4999	Histidine kinase
EP12_14570	COG3850	Histidine kinase
EP12_14570	COG3437	response regulator, receiver
EP12_14570	COG2205	protein histidine kinase activity
EP12_14580	COG4555	ABC transporter
EP12_14585	COG0513	Belongs to the DEAD box helicase family
EP12_14600	COG0235	Class ii aldolase
EP12_14625	COG1312	Catalyzes the dehydration of D-mannonate
EP12_14640	COG3177	Filamentation induced by cAMP protein fic
EP12_14765	COG0583	DNA-binding transcription factor activity
EP12_14770	COG0006	proline dipeptidase activity
EP12_14780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_14785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP12_14790	COG0006	proline dipeptidase activity
EP12_14800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_14805	COG1957	nucleoside hydrolase
EP12_14810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP12_14815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP12_14820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP12_14860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_14865	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP12_14870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP12_14880	COG2186	Transcriptional regulator
EP12_14895	COG3577	Aspartyl protease
EP12_14905	COG4969	Belongs to the N-Me-Phe pilin family
EP12_14910	COG1459	type II secretion system
EP12_14920	COG0237	dephospho-CoA kinase activity
EP12_14925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EP12_14930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP12_14955	COG2814	Major facilitator Superfamily
EP12_14970	COG3608	succinylglutamate desuccinylase aspartoacylase
EP12_14985	COG0739	heme binding
EP12_14990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP12_14995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP12_15000	COG0849	cell division
EP12_15005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP12_15010	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP12_15015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP12_15025	COG0772	Belongs to the SEDS family
EP12_15030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP12_15040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP12_15055	COG3116	cell division
EP12_15065	COG2001	Belongs to the MraZ family
EP12_15080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP12_15105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP12_15105	COG0678	peroxiredoxin activity
EP12_15120	COG2204	response regulator
EP12_15140	COG2084	Dehydrogenase
EP12_15175	COG0668	transmembrane transport
EP12_15185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP12_15200	COG1678	Uncharacterized ACR, COG1678
EP12_15205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP12_15225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP12_15230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EP12_15235	COG0762	integral membrane protein
EP12_15275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP12_15310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP12_15315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP12_15330	COG0583	DNA-binding transcription factor activity
EP12_15345	COG0640	Transcriptional regulator
EP12_15355	COG0431	NADPH-dependent FMN reductase
EP12_15360	COG0798	PFAM Bile acid sodium symporter
EP12_15365	COG2201	protein-glutamate methylesterase activity
EP12_15370	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EP12_15395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP12_15405	COG1748	Saccharopine dehydrogenase
EP12_15420	COG3706	GGDEF domain
EP12_15425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EP12_15435	COG0792	nuclease activity
EP12_15445	COG2823	Periplasmic or secreted lipoprotein
EP12_15470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EP12_15475	COG0372	Belongs to the citrate synthase family
EP12_15485	COG2828	Protein conserved in bacteria
EP12_15490	COG2199	diguanylate cyclase activity
EP12_15490	COG2203	Gaf domain
EP12_15510	COG5002	protein histidine kinase activity
EP12_15510	COG2198	Histidine kinase
EP12_15510	COG0784	Response regulator, receiver
EP12_15515	COG3023	N-Acetylmuramoyl-L-alanine amidase
EP12_15525	COG0067	glutamate synthase
EP12_15525	COG0070	glutamate synthase
EP12_15525	COG0069	glutamate synthase activity
EP12_15530	COG0493	'glutamate synthase
EP12_15545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP12_15585	COG1304	FMN binding
EP12_15590	COG4952	isomerase
EP12_15595	COG3347	Dehydrogenase
EP12_15595	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_15610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_15620	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_15635	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP12_15650	COG3254	rhamnose metabolic process
EP12_15665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP12_15675	COG5507	3-demethylubiquinone-9 3-methyltransferase
EP12_15680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP12_15685	COG1196	nuclear chromosome segregation
EP12_15685	COG0741	lytic transglycosylase activity
EP12_15685	COG0739	heme binding
EP12_15690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP12_15695	COG3437	response regulator, receiver
EP12_15725	COG0625	glutathione transferase activity
EP12_15755	COG2894	cell division
EP12_15760	COG0850	regulation of cytokinetic process
EP12_15805	COG1914	H( )-stimulated, divalent metal cation uptake system
EP12_15830	COG0174	glutamine synthetase
EP12_15840	COG3852	Histidine kinase
EP12_15845	COG2204	response regulator
EP12_15850	COG3437	response regulator, receiver
EP12_15855	COG0204	Acyl-transferase
EP12_15885	COG0525	valine-tRNA ligase activity
EP12_15890	COG2927	DNA polymerase III (CHI subunit)
EP12_15895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP12_15910	COG0840	transmembrane signaling receptor activity
EP12_15915	COG3588	fructose-bisphosphate aldolase
EP12_15945	COG3842	ATPase activity
EP12_15950	COG3842	ATPase activity
EP12_15955	COG3284	Transcriptional regulator
EP12_15960	COG0149	triose-phosphate isomerase activity
EP12_15965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP12_15970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP12_15980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP12_15985	COG3842	ATPase activity
EP12_16000	COG0795	lipopolysaccharide-transporting ATPase activity
EP12_16005	COG0795	lipopolysaccharide-transporting ATPase activity
EP12_16035	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_16045	COG3246	L-lysine catabolic process to acetate
EP12_16135	COG3250	beta-galactosidase activity
EP12_16155	COG4948	Mandelate Racemase Muconate Lactonizing
EP12_16160	COG3661	Belongs to the glycosyl hydrolase 67 family
EP12_16175	COG4946	Tricorn protease homolog
EP12_16175	COG0793	Belongs to the peptidase S41A family
EP12_16230	COG4206	TonB-dependent receptor
EP12_16240	COG4139	cobalamin transport
EP12_16250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP12_16270	COG1028	Short-chain dehydrogenase reductase Sdr
EP12_16285	COG1609	Transcriptional regulator
EP12_16305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP12_16325	COG2267	carboxylic ester hydrolase activity
EP12_16340	COG1116	anion transmembrane transporter activity
EP12_16365	COG0513	Belongs to the DEAD box helicase family
EP12_16370	COG0800	Aldolase
EP12_16375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP12_16390	COG3264	Mechanosensitive ion channel
EP12_16390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP12_16420	COG0475	glutathione-regulated potassium exporter activity
EP12_16420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP12_16435	COG3568	Endonuclease Exonuclease Phosphatase
EP12_16450	COG0730	response to heat
EP12_16455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP12_16475	COG0417	DNA replication proofreading
EP12_16525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_16535	COG1573	uracil-dna glycosylase
EP12_16560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP12_16585	COG1842	Phage shock protein A
EP12_16600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP12_16620	COG4529	Protein conserved in bacteria
EP12_16650	COG0204	Acyl-transferase
EP12_16655	COG0204	Acyl-transferase
EP12_16675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP12_16680	COG0733	neurotransmitter:sodium symporter activity
EP12_16695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP12_16710	COG0716	FMN binding
EP12_16720	COG0848	biopolymer transport protein
EP12_16730	COG0457	Tetratricopeptide repeat
EP12_16735	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EP12_16760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EP12_16780	COG5001	Diguanylate cyclase
EP12_16780	COG5002	protein histidine kinase activity
EP12_16790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP12_16795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP12_16805	COG0583	DNA-binding transcription factor activity
EP12_16830	COG0121	glutamine amidotransferase
EP12_16855	COG1522	sequence-specific DNA binding
EP12_16875	COG1136	(ABC) transporter
EP12_16875	COG0577	efflux transmembrane transporter activity
EP12_16890	COG4628	conserved protein (DUF2132)
EP12_16900	COG3265	gluconokinase activity
EP12_16905	COG1609	Transcriptional regulator
EP12_16920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP12_16935	COG2871	sodium ion transport
EP12_16940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_16945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_16955	COG1805	sodium ion transport
EP12_16960	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP12_16965	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP12_16970	COG0545	Peptidyl-prolyl cis-trans isomerase
EP12_16975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP12_16995	COG0039	L-malate dehydrogenase activity
EP12_17000	COG1438	arginine binding
EP12_17005	COG4206	TonB-dependent receptor
EP12_17035	COG0572	uridine kinase
EP12_17040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EP12_17070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_17080	COG5002	protein histidine kinase activity
EP12_17080	COG2198	Histidine kinase
EP12_17080	COG0784	Response regulator, receiver
EP12_17090	COG0189	ligase activity
EP12_17100	COG4067	protein conserved in archaea
EP12_17100	COG0189	ligase activity
EP12_17115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP12_17125	COG1283	sodium-dependent phosphate transmembrane transporter activity
EP12_17130	COG0667	Aldo Keto reductase
EP12_17145	COG0753	catalase activity
EP12_17255	COG0583	DNA-binding transcription factor activity
EP12_17285	COG1216	Glycosyl transferase, family 2
EP12_17285	COG0438	transferase activity, transferring glycosyl groups
EP12_17295	COG1091	dTDP-4-dehydrorhamnose reductase activity
EP12_17320	COG0463	Glycosyl transferase, family 2
EP12_17325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP12_17335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EP12_17365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP12_17370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_17370	COG0473	3-isopropylmalate dehydrogenase activity
EP12_17400	COG0662	Cupin 2, conserved barrel domain protein
EP12_17400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EP12_17420	COG0202	RNA polymerase activity
EP12_17440	COG0201	protein transport
EP12_17460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP12_17525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EP12_17555	COG2234	aminopeptidase activity
EP12_17595	COG1271	oxidase subunit
EP12_17600	COG1294	oxidase, subunit
EP12_17615	COG1278	Cold shock
EP12_17620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP12_17640	COG0339	signal peptide processing
EP12_17645	COG2201	protein-glutamate methylesterase activity
EP12_17655	COG4191	Histidine kinase
EP12_17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP12_17670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP12_17675	COG0823	Involved in the tonB-independent uptake of proteins
EP12_17675	COG1506	peptidase
EP12_17675	COG4946	Tricorn protease homolog
EP12_17715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EP12_17720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP12_17725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP12_17740	COG0281	malic enzyme
EP12_17750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP12_17780	COG0456	acetyltransferase
EP12_17800	COG2177	Part of the ABC transporter FtsEX involved in
EP12_17805	COG2884	Cell division ATP-binding protein ftsE
EP12_17810	COG0552	protein localization to endoplasmic reticulum
EP12_17820	COG3068	Protein conserved in bacteria
EP12_17825	COG2095	MarC family integral membrane protein
EP12_17845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP12_17860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP12_17875	COG0076	glutamate decarboxylase activity
EP12_17890	COG1131	(ABC) transporter
EP12_17900	COG0745	RESPONSE REGULATOR receiver
EP12_17905	COG2205	protein histidine kinase activity
EP12_17910	COG4774	siderophore transport
EP12_17930	COG1253	flavin adenine dinucleotide binding
EP12_17935	COG0701	Predicted permease
EP12_17940	COG1966	Carbon starvation protein
EP12_17985	COG0049	tRNA binding
EP12_17990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP12_18000	COG0085	RNA polymerase activity
EP12_18010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP12_18020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP12_18035	COG0250	Participates in transcription elongation, termination and antitermination
EP12_18040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP12_18065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP12_18085	COG0418	dihydroorotase activity
EP12_18095	COG3040	lipid binding
EP12_18100	COG4989	oxidoreductase activity
EP12_18120	COG0302	gtp cyclohydrolase
EP12_18130	COG2957	Belongs to the agmatine deiminase family
EP12_18135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP12_18145	COG3706	GGDEF domain
EP12_18155	COG2207	Transcriptional regulator
EP12_18210	COG1201	RNA secondary structure unwinding
EP12_18220	COG1793	dna ligase
EP12_18240	COG0625	glutathione transferase activity
EP12_18250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP12_18260	COG1012	belongs to the aldehyde dehydrogenase family
EP12_18275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP12_18290	COG0330	HflC and HflK could
EP12_18295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP12_18300	COG1923	regulation of RNA biosynthetic process
EP12_18305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP12_18320	COG0802	atpase or kinase
EP12_18330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EP12_18355	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EP12_18360	COG0735	belongs to the Fur family
EP12_18370	COG0432	Pfam Uncharacterised protein family UPF0047
EP12_18425	COG5002	protein histidine kinase activity
EP12_18450	COG1609	Transcriptional regulator
EP12_18460	COG2723	6-phospho-beta-galactosidase activity
EP12_18480	COG0789	Transcriptional regulator
EP12_18500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP12_18520	COG4771	TonB-dependent receptor
EP12_18540	COG3706	GGDEF domain
EP12_18555	COG4890	Cyd operon protein YbgT
EP12_18560	COG1294	oxidase, subunit
EP12_18670	COG3237	CsbD-like
EP12_18685	COG4771	TonB-dependent receptor
EP12_18695	COG0457	Tetratricopeptide repeat
EP12_18755	COG2235	arginine
EP12_18780	COG1595	DNA-templated transcription, initiation
EP12_18810	COG2267	carboxylic ester hydrolase activity
EP12_18860	COG2130	NADP-dependent
EP12_18865	COG3706	GGDEF domain
EP12_18865	COG0745	RESPONSE REGULATOR receiver
EP12_18895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP12_18905	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP12_18925	COG0656	L-ascorbic acid biosynthetic process
EP12_18930	COG2175	clavaminate synthase activity
EP12_18935	COG2855	membrane
EP12_18970	COG1349	DNA-binding transcription factor activity
EP12_18975	COG0673	inositol 2-dehydrogenase activity
EP12_19000	COG2169	Transcriptional regulator
EP12_19025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP12_19030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP12_19065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP12_19110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP12_19145	COG1335	isochorismatase
EP12_19150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP12_19165	COG3384	dioxygenase
EP12_19175	COG2175	clavaminate synthase activity
EP12_19200	COG1324	tolerance protein
EP12_19215	COG0511	ligase activity, forming carbon-carbon bonds
EP12_19220	COG0439	Biotin carboxylase
EP12_19295	COG0151	Belongs to the GarS family
EP12_19325	COG0745	RESPONSE REGULATOR receiver
EP12_19345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP12_19375	COG2165	general secretion pathway protein
EP12_19390	COG4795	General secretion pathway protein
EP12_19405	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EP12_19420	COG1012	belongs to the aldehyde dehydrogenase family
EP12_19430	COG1011	Hydrolase
EP12_19455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EP12_19465	COG3089	Belongs to the UPF0270 family
EP12_19505	COG0545	Peptidyl-prolyl cis-trans isomerase
EP12_19515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP12_19540	COG1040	competence protein
EP12_19560	COG1794	racemase activity, acting on amino acids and derivatives
EP12_19565	COG2226	methyltransferase
EP12_19580	COG0534	Mate efflux family protein
EP12_19600	COG0109	protoheme IX farnesyltransferase activity
EP12_19650	COG4774	siderophore transport
EP12_19675	COG2860	membrane
EP12_19685	COG0583	DNA-binding transcription factor activity
EP12_19695	COG2814	Major facilitator Superfamily
EP12_19700	COG0729	surface antigen
EP12_19725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP12_19800	COG0425	Belongs to the sulfur carrier protein TusA family
EP12_19840	COG0582	viral genome integration into host DNA
EP12_19845	COG2003	Belongs to the UPF0758 family
EP12_19890	COG0210	DNA helicase
EP12_19980	COG2211	Major facilitator Superfamily
EP12_20035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP12_20060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP12_20080	COG1475	DNA binding
EP12_20085	COG1192	Involved in chromosome partitioning
EP12_20110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP12_20115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP12_20125	COG0706	membrane insertase activity
EP12_20130	COG0594	ribonuclease P activity