locus-tag	class	description
EP13_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP13_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP13_00040	COG2818	Glycosylase
EP13_00050	COG3078	GTPase activator activity
EP13_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP13_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP13_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EP13_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP13_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP13_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP13_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP13_00105	COG1652	LysM domain
EP13_00110	COG0758	DNA mediated transformation
EP13_00125	COG0009	L-threonylcarbamoyladenylate synthase
EP13_00130	COG0408	coproporphyrinogen oxidase activity
EP13_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP13_00225	COG2234	aminopeptidase activity
EP13_00230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP13_00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP13_00275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_00305	COG3642	lipopolysaccharide core region biosynthetic process
EP13_00310	COG0859	PFAM glycosyl transferase family 9
EP13_00330	COG0156	8-amino-7-oxononanoate synthase activity
EP13_00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_00345	COG0705	Rhomboid family
EP13_00355	COG3161	chorismate lyase activity
EP13_00360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP13_00365	COG2960	long-chain fatty acid transporting porin activity
EP13_00370	COG0210	DNA helicase
EP13_00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_00465	COG0842	Transport permease protein
EP13_00465	COG1129	ABC transporter
EP13_00470	COG0842	Transport permease protein
EP13_00475	COG4773	Receptor
EP13_00480	COG4771	TonB-dependent receptor
EP13_00485	COG1960	acyl-CoA dehydrogenase activity
EP13_00490	COG0583	DNA-binding transcription factor activity
EP13_00500	COG3106	COG3106 Predicted ATPase
EP13_00515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP13_00535	COG0352	thiamine-phosphate diphosphorylase activity
EP13_00545	COG4771	TonB-dependent receptor
EP13_00560	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EP13_00560	COG0778	Nitroreductase
EP13_00575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP13_00580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP13_00585	COG1309	transcriptional regulator
EP13_00615	COG1953	Uracil, thiamine, allantoin
EP13_00625	COG3071	HemY protein
EP13_00630	COG2959	enzyme of heme biosynthesis
EP13_00635	COG1587	Uroporphyrinogen-III synthase
EP13_00640	COG0181	hydroxymethylbilane synthase activity
EP13_00645	COG3706	GGDEF domain
EP13_00645	COG0745	RESPONSE REGULATOR receiver
EP13_00655	COG0194	GDP metabolic process
EP13_00665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP13_00675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP13_00680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP13_00690	COG0678	peroxiredoxin activity
EP13_00710	COG1178	ABC-type Fe3 transport system permease component
EP13_00715	COG3842	ATPase activity
EP13_00720	COG0668	transmembrane transport
EP13_00725	COG2081	HI0933 family
EP13_00735	COG4774	siderophore transport
EP13_00750	COG0745	RESPONSE REGULATOR receiver
EP13_00755	COG0457	Tetratricopeptide repeat
EP13_00780	COG0010	Belongs to the arginase family
EP13_00785	COG0010	Belongs to the arginase family
EP13_00790	COG0784	Response regulator, receiver
EP13_00790	COG5002	protein histidine kinase activity
EP13_00790	COG2198	Histidine kinase
EP13_00805	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP13_00810	COG0411	ABC transporter
EP13_00820	COG0829	nickel cation binding
EP13_00825	COG0831	urea catabolic process
EP13_00845	COG0830	nickel cation binding
EP13_00875	COG0583	DNA-binding transcription factor activity
EP13_00895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_00910	COG0427	acetyl-CoA hydrolase
EP13_00915	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP13_00950	COG5002	protein histidine kinase activity
EP13_00950	COG5001	Diguanylate cyclase
EP13_00965	COG0514	ATP-dependent DNA helicase (RecQ)
EP13_00970	COG2050	protein possibly involved in aromatic compounds catabolism
EP13_00975	COG2239	Acts as a magnesium transporter
EP13_00980	COG2962	Rard protein
EP13_00985	COG0745	RESPONSE REGULATOR receiver
EP13_00985	COG3706	GGDEF domain
EP13_00990	COG0210	DNA helicase
EP13_01000	COG1011	Hydrolase
EP13_01015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP13_01020	COG0019	diaminopimelate decarboxylase activity
EP13_01050	COG0163	prenyltransferase activity
EP13_01055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP13_01065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP13_01090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP13_01095	COG2814	Major facilitator Superfamily
EP13_01100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_01130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EP13_01140	COG0629	single-stranded DNA binding
EP13_01170	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_01185	COG1349	DNA-binding transcription factor activity
EP13_01205	COG1077	Cell shape determining protein MreB Mrl
EP13_01210	COG1792	Involved in formation and maintenance of cell shape
EP13_01215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP13_01220	COG0424	maF-like protein
EP13_01225	COG1530	ribonuclease E activity
EP13_01230	COG3164	Protein of unknown function
EP13_01235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_01240	COG0312	modulator of DNA gyrase
EP13_01245	COG3028	Belongs to the UPF0307 family
EP13_01250	COG0312	modulator of DNA gyrase
EP13_01265	COG0745	RESPONSE REGULATOR receiver
EP13_01270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_01270	COG4191	Histidine kinase
EP13_01275	COG0297	glycogen (starch) synthase activity
EP13_01285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP13_01345	COG3341	Caulimovirus viroplasmin
EP13_01345	COG0328	RNA-DNA hybrid ribonuclease activity
EP13_01365	COG4974	Belongs to the 'phage' integrase family
EP13_01395	COG5002	protein histidine kinase activity
EP13_01400	COG0745	RESPONSE REGULATOR receiver
EP13_01420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_01510	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EP13_01540	COG0375	protein maturation
EP13_01550	COG0409	Hydrogenase expression formation protein
EP13_01555	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EP13_01560	COG0309	Hydrogenase expression formation protein (HypE)
EP13_01565	COG0789	Transcriptional regulator
EP13_01570	COG2217	Heavy metal translocating P-type atpase
EP13_01650	COG0531	amino acid
EP13_01660	COG2132	Multicopper oxidase
EP13_01685	COG4771	TonB-dependent receptor
EP13_01725	COG2378	regulation of single-species biofilm formation
EP13_01735	COG4771	TonB-dependent receptor
EP13_01765	COG0840	transmembrane signaling receptor activity
EP13_01770	COG0745	RESPONSE REGULATOR receiver
EP13_01775	COG0643	Histidine kinase
EP13_01775	COG2198	Histidine kinase
EP13_01780	COG0835	chemotaxis
EP13_01795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP13_01830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP13_01845	COG1609	Transcriptional regulator
EP13_01850	COG0673	inositol 2-dehydrogenase activity
EP13_01860	COG2211	Major facilitator Superfamily
EP13_01865	COG1082	Xylose isomerase domain protein TIM barrel
EP13_01920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP13_01930	COG0051	transcription antitermination factor activity, RNA binding
EP13_01945	COG0089	rRNA binding
EP13_01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP13_01965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP13_01980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP13_01985	COG0438	transferase activity, transferring glycosyl groups
EP13_01995	COG1519	Transferase
EP13_02030	COG0788	formyltetrahydrofolate deformylase activity
EP13_02060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP13_02075	COG2354	Protein conserved in bacteria
EP13_02080	COG2169	Transcriptional regulator
EP13_02100	COG0004	ammonium transporteR
EP13_02110	COG0405	Gamma-glutamyltransferase
EP13_02115	COG2837	iron assimilation
EP13_02125	COG0540	Belongs to the ATCase OTCase family
EP13_02165	COG5001	Diguanylate cyclase
EP13_02165	COG3300	MHYT domain
EP13_02175	COG1012	belongs to the aldehyde dehydrogenase family
EP13_02185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP13_02195	COG0512	Glutamine amidotransferase of anthranilate synthase
EP13_02200	COG0180	Tryptophanyl-tRNA synthetase
EP13_02205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP13_02235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP13_02270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP13_02275	COG0281	malic enzyme
EP13_02285	COG0625	glutathione transferase activity
EP13_02290	COG0753	catalase activity
EP13_02310	COG5001	Diguanylate cyclase
EP13_02310	COG3300	MHYT domain
EP13_02315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP13_02315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP13_02325	COG0137	argininosuccinate synthase activity
EP13_02345	COG1803	Methylglyoxal synthase
EP13_02355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EP13_02370	COG0745	RESPONSE REGULATOR receiver
EP13_02375	COG2205	protein histidine kinase activity
EP13_02380	COG2267	carboxylic ester hydrolase activity
EP13_02385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP13_02395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP13_02405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP13_02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_02415	COG4942	peptidase
EP13_02450	COG1162	GTPase activity
EP13_02455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP13_02490	COG0028	Belongs to the TPP enzyme family
EP13_02510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP13_02515	COG0805	protein transport
EP13_02530	COG3706	GGDEF domain
EP13_02540	COG0248	Ppx GppA phosphatase
EP13_02545	COG0513	Belongs to the DEAD box helicase family
EP13_02550	COG3118	belongs to the thioredoxin family
EP13_02560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP13_02565	COG1473	amidohydrolase
EP13_02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP13_02585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EP13_02600	COG0783	Belongs to the Dps family
EP13_02605	COG2133	pyrroloquinoline quinone binding
EP13_02610	COG1506	peptidase
EP13_02610	COG4946	Tricorn protease homolog
EP13_02610	COG0823	Involved in the tonB-independent uptake of proteins
EP13_02620	COG3118	belongs to the thioredoxin family
EP13_02630	COG1012	belongs to the aldehyde dehydrogenase family
EP13_02640	COG1757	Na H antiporter
EP13_02655	COG3876	Protein conserved in bacteria
EP13_02660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EP13_02745	COG1247	-acetyltransferase
EP13_02765	COG0519	Catalyzes the synthesis of GMP from XMP
EP13_02805	COG1228	amidohydrolase
EP13_02840	COG0183	Belongs to the thiolase family
EP13_02845	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_02845	COG1024	Enoyl-CoA hydratase
EP13_02860	COG0006	proline dipeptidase activity
EP13_02870	COG0142	geranyltranstransferase activity
EP13_02920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP13_02925	COG4942	peptidase
EP13_02925	COG1388	LysM domain
EP13_02930	COG1238	metal cluster binding
EP13_02940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP13_02945	COG0585	pseudouridine synthase activity
EP13_02960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP13_02970	COG0840	transmembrane signaling receptor activity
EP13_02980	COG1538	Outer membrane efflux protein
EP13_02990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_03000	COG5002	protein histidine kinase activity
EP13_03010	COG3025	triphosphatase activity
EP13_03025	COG0494	nUDIX hydrolase
EP13_03035	COG0730	response to heat
EP13_03040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP13_03045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP13_03055	COG3706	GGDEF domain
EP13_03080	COG0564	pseudouridine synthase activity
EP13_03085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EP13_03095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP13_03105	COG1648	precorrin-2 dehydrogenase activity
EP13_03105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP13_03130	COG1538	Outer membrane efflux protein
EP13_03135	COG0494	nUDIX hydrolase
EP13_03140	COG3151	Protein conserved in bacteria
EP13_03150	COG3150	esterase
EP13_03155	COG0187	DNA topoisomerase II activity
EP13_03165	COG4251	negative regulation of phosphorylation
EP13_03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_03190	COG1509	lysine 2,3-aminomutase activity
EP13_03200	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EP13_03215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP13_03230	COG0271	Belongs to the BolA IbaG family
EP13_03235	COG0671	phosphoesterase, PA-phosphatase related
EP13_03245	COG3707	response regulator
EP13_03255	COG0659	secondary active sulfate transmembrane transporter activity
EP13_03260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP13_03265	COG2146	nitrite reductase [NAD(P)H] activity
EP13_03270	COG0243	molybdopterin cofactor binding
EP13_03275	COG1648	precorrin-2 dehydrogenase activity
EP13_03275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP13_03280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP13_03290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP13_03290	COG1116	anion transmembrane transporter activity
EP13_03295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP13_03300	COG1116	anion transmembrane transporter activity
EP13_03310	COG0746	molybdenum cofactor guanylyltransferase activity
EP13_03320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP13_03325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP13_03330	COG0348	domain, Protein
EP13_03345	COG1960	acyl-CoA dehydrogenase activity
EP13_03350	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_03360	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_03380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_03420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP13_03425	COG0358	DNA primase activity
EP13_03445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP13_03465	COG0537	adenosine 5'-monophosphoramidase activity
EP13_03480	COG3135	benzoate transporter
EP13_03485	COG1396	sequence-specific DNA binding
EP13_03490	COG2974	May be involved in recombination
EP13_03495	COG4191	Histidine kinase
EP13_03495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_03500	COG0745	RESPONSE REGULATOR receiver
EP13_03505	COG5002	protein histidine kinase activity
EP13_03535	COG0811	peptide transport
EP13_03540	COG0811	peptide transport
EP13_03545	COG0848	biopolymer transport protein
EP13_03550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EP13_03560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP13_03570	COG0784	Response regulator, receiver
EP13_03570	COG5002	protein histidine kinase activity
EP13_03570	COG2205	protein histidine kinase activity
EP13_03575	COG0318	PFAM AMP-dependent synthetase and ligase
EP13_03615	COG0527	aspartate kinase activity
EP13_03620	COG0840	transmembrane signaling receptor activity
EP13_03625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP13_03630	COG2967	ApaG domain
EP13_03635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP13_03640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP13_03645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_03650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP13_03660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EP13_03670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP13_03690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP13_03705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP13_03710	COG3956	TIGRFAM MazG family protein
EP13_03725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP13_03730	COG1595	DNA-templated transcription, initiation
EP13_03750	COG0723	plastoquinol--plastocyanin reductase activity
EP13_03755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP13_03760	COG2857	Cytochrome c1
EP13_03765	COG0625	glutathione transferase activity
EP13_03770	COG2969	positive regulation of protein catabolic process
EP13_03785	COG0745	RESPONSE REGULATOR receiver
EP13_03790	COG2239	Acts as a magnesium transporter
EP13_03795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP13_03805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP13_03815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EP13_03820	COG1137	ATPase activity
EP13_03835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP13_03850	COG1127	ABC transporter
EP13_03855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP13_03860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP13_03865	COG2854	intermembrane phospholipid transfer
EP13_03875	COG5007	Belongs to the BolA IbaG family
EP13_03885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP13_03890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP13_03905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EP13_03965	COG3209	COG3209 Rhs family protein
EP13_04015	COG0784	Response regulator, receiver
EP13_04015	COG2205	protein histidine kinase activity
EP13_04030	COG1979	alcohol dehydrogenase
EP13_04055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP13_04065	COG0126	phosphoglycerate kinase activity
EP13_04070	COG3588	fructose-bisphosphate aldolase
EP13_04075	COG0248	Ppx GppA phosphatase
EP13_04080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP13_04090	COG0573	inorganic phosphate transmembrane transporter activity
EP13_04100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP13_04110	COG0306	phosphate transporter
EP13_04115	COG0589	response to stress
EP13_04120	COG0583	DNA-binding transcription factor activity
EP13_04130	COG1272	protein, Hemolysin III
EP13_04135	COG1846	Transcriptional regulator
EP13_04140	COG1764	response to oxidative stress
EP13_04150	COG1739	Uncharacterized protein family UPF0029
EP13_04165	COG0419	ATPase involved in DNA repair
EP13_04195	COG0625	glutathione transferase activity
EP13_04220	COG2971	BadF BadG BcrA BcrD
EP13_04230	COG0488	(ABC) transporter
EP13_04245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP13_04290	COG1609	Transcriptional regulator
EP13_04330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EP13_04335	COG0732	type I restriction modification DNA specificity domain
EP13_04345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP13_04400	COG1346	cytolysis
EP13_04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP13_04435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP13_04440	COG0513	Belongs to the DEAD box helicase family
EP13_04450	COG3267	Type II secretory pathway component ExeA
EP13_04450	COG3409	Peptidoglycan-binding domain 1 protein
EP13_04465	COG0066	3-isopropylmalate dehydratase activity
EP13_04475	COG0473	3-isopropylmalate dehydrogenase activity
EP13_04480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP13_04510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP13_04535	COG4555	ABC transporter
EP13_04540	COG1668	transmembrane transport
EP13_04555	COG4133	protoheme IX ABC transporter activity
EP13_04560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_04570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP13_04580	COG1138	Cytochrome C-type biogenesis protein
EP13_04585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP13_04600	COG2853	Lipoprotein
EP13_04605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP13_04615	COG3104	oligopeptide transport
EP13_04645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP13_04650	COG1216	Glycosyl transferase, family 2
EP13_04650	COG0463	Glycosyl transferase, family 2
EP13_04660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP13_04665	COG1555	photosystem II stabilization
EP13_04665	COG1596	polysaccharide export
EP13_04670	COG0473	3-isopropylmalate dehydrogenase activity
EP13_04685	COG1611	Belongs to the LOG family
EP13_04690	COG3706	GGDEF domain
EP13_04690	COG0745	RESPONSE REGULATOR receiver
EP13_04695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP13_04695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP13_04750	COG0564	pseudouridine synthase activity
EP13_04765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP13_04770	COG0024	Methionine aminopeptidase
EP13_04775	COG0052	Belongs to the universal ribosomal protein uS2 family
EP13_04785	COG0528	UMP kinase activity
EP13_04795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP13_04800	COG0575	Belongs to the CDS family
EP13_04810	COG0750	zinc metalloprotease
EP13_04825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP13_04845	COG0587	DNA-directed DNA polymerase activity
EP13_04850	COG0825	malonyl-CoA metabolic process
EP13_04875	COG0590	tRNA wobble adenosine to inosine editing
EP13_04895	COG2840	Smr protein MutS2
EP13_04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_04925	COG2197	response regulator
EP13_04965	COG0784	Response regulator, receiver
EP13_04965	COG0835	chemotaxis
EP13_04970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP13_04975	COG1815	bacterial-type flagellum-dependent cell motility
EP13_04980	COG1558	bacterial-type flagellum-dependent cell motility
EP13_04985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EP13_04990	COG1749	Flagellar hook protein flgE
EP13_04995	COG4787	bacterial-type flagellum-dependent cell motility
EP13_05000	COG4786	Flagellar basal body rod
EP13_05015	COG1705	Flagellar rod assembly protein muramidase FlgJ
EP13_05015	COG3951	Flagellar rod assembly protein muramidase FlgJ
EP13_05020	COG1256	bacterial-type flagellum assembly
EP13_05040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP13_05050	COG1334	flagellar protein FlaG
EP13_05060	COG1516	flagellar protein fliS
EP13_05070	COG1086	Polysaccharide biosynthesis protein
EP13_05075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP13_05080	COG1083	cytidylyl-transferase
EP13_05085	COG2089	acid synthase
EP13_05105	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_05135	COG1442	glycosyl transferase family 8
EP13_05140	COG1216	Glycosyl transferase, family 2
EP13_05175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP13_05190	COG2204	response regulator
EP13_05195	COG3852	Histidine kinase
EP13_05200	COG2204	response regulator
EP13_05205	COG1677	Flagellar hook-basal body complex protein FliE
EP13_05210	COG1766	The M ring may be actively involved in energy transduction
EP13_05215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP13_05265	COG1987	bacterial-type flagellum assembly
EP13_05280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP13_05290	COG0455	bacterial-type flagellum organization
EP13_05305	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EP13_05310	COG0643	Histidine kinase
EP13_05310	COG2198	Histidine kinase
EP13_05320	COG1192	Involved in chromosome partitioning
EP13_05330	COG0835	chemotaxis
EP13_05360	COG3123	guanosine phosphorylase activity
EP13_05365	COG0583	DNA-binding transcription factor activity
EP13_05370	COG0583	DNA-binding transcription factor activity
EP13_05375	COG0288	reversible hydration of carbon dioxide
EP13_05380	COG0659	secondary active sulfate transmembrane transporter activity
EP13_05395	COG2137	regulation of response to DNA damage stimulus
EP13_05400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP13_05435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EP13_05440	COG4172	Belongs to the ABC transporter superfamily
EP13_05445	COG4172	Belongs to the ABC transporter superfamily
EP13_05450	COG4171	peptide transport system, permease
EP13_05455	COG0601	transmembrane transport
EP13_05460	COG0747	negative chemotaxis
EP13_05465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EP13_05470	COG1842	Phage shock protein A
EP13_05510	COG0625	glutathione transferase activity
EP13_05515	COG1522	sequence-specific DNA binding
EP13_05550	COG0811	peptide transport
EP13_05555	COG0811	peptide transport
EP13_05560	COG0848	biopolymer transport protein
EP13_05615	COG0456	acetyltransferase
EP13_05630	COG0583	DNA-binding transcription factor activity
EP13_05635	COG2814	Major facilitator Superfamily
EP13_05640	COG0656	L-ascorbic acid biosynthetic process
EP13_05680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP13_05690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP13_05705	COG0633	Ferredoxin
EP13_05705	COG0543	2 iron, 2 sulfur cluster binding
EP13_05845	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_05925	COG3547	Transposase (IS116 IS110 IS902 family)
EP13_06020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP13_06025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EP13_06040	COG0612	Peptidase, M16
EP13_06045	COG2918	glutathione biosynthetic process
EP13_06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_06060	COG1136	(ABC) transporter
EP13_06070	COG0577	efflux transmembrane transporter activity
EP13_06070	COG1136	(ABC) transporter
EP13_06090	COG2840	Smr protein MutS2
EP13_06095	COG2890	protein-(glutamine-N5) methyltransferase activity
EP13_06115	COG2719	SpoVR family
EP13_06120	COG2718	Belongs to the UPF0229 family
EP13_06125	COG2766	serine protein kinase
EP13_06135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP13_06140	COG4771	TonB-dependent receptor
EP13_06165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP13_06170	COG2885	chlorophyll binding
EP13_06175	COG0584	glycerophosphoryl diester phosphodiesterase
EP13_06180	COG0346	lactoylglutathione lyase activity
EP13_06185	COG1278	Cold shock
EP13_06195	COG3706	GGDEF domain
EP13_06200	COG3710	Transcriptional regulator
EP13_06245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP13_06280	COG2808	Putative FMN-binding domain
EP13_06290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP13_06300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP13_06305	COG4660	Part of a membrane complex involved in electron transport
EP13_06310	COG4659	FMN binding
EP13_06315	COG4658	electron transport chain
EP13_06320	COG4656	Part of a membrane complex involved in electron transport
EP13_06325	COG2878	Part of a membrane complex involved in electron transport
EP13_06330	COG4657	Part of a membrane complex involved in electron transport
EP13_06345	COG0534	Mate efflux family protein
EP13_06350	COG0556	nucleotide-excision repair
EP13_06375	COG0602	queuosine metabolic process
EP13_06385	COG0367	asparagine synthase
EP13_06410	COG3273	potassium ion transport
EP13_06410	COG0471	metal ion transport
EP13_06425	COG0529	Catalyzes the synthesis of activated sulfate
EP13_06430	COG0175	sulfate reduction
EP13_06435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_06450	COG1595	DNA-templated transcription, initiation
EP13_06465	COG2304	oxidoreductase activity
EP13_06485	COG0714	Associated with various cellular activities
EP13_06495	COG1024	Enoyl-CoA hydratase
EP13_06495	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_06520	COG1025	Belongs to the peptidase M16 family
EP13_06525	COG2062	phosphohistidine phosphatase, SixA
EP13_06535	COG4536	flavin adenine dinucleotide binding
EP13_06540	COG4137	Cytochrome C assembly protein
EP13_06550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP13_06595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_06600	COG1132	(ABC) transporter
EP13_06620	COG0228	four-way junction DNA binding
EP13_06625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP13_06630	COG0336	Belongs to the RNA methyltransferase TrmD family
EP13_06635	COG0335	large ribosomal subunit rRNA binding
EP13_06640	COG2860	membrane
EP13_06655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP13_06660	COG1605	Chorismate mutase
EP13_06660	COG0287	Prephenate dehydrogenase
EP13_06665	COG1605	Chorismate mutase
EP13_06665	COG0077	Prephenate dehydratase
EP13_06670	COG0745	RESPONSE REGULATOR receiver
EP13_06675	COG0023	Translation Initiation Factor
EP13_06705	COG2205	protein histidine kinase activity
EP13_06715	COG2204	response regulator
EP13_06720	COG1801	Protein of unknown function DUF72
EP13_06725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP13_06730	COG0494	nUDIX hydrolase
EP13_06745	COG2255	four-way junction helicase activity
EP13_06750	COG0824	Thioesterase
EP13_06755	COG0811	peptide transport
EP13_06770	COG0823	Involved in the tonB-independent uptake of proteins
EP13_06775	COG2885	chlorophyll binding
EP13_06780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EP13_06800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP13_06810	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_06820	COG1451	nucleotide metabolic process
EP13_06835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_06845	COG0612	Peptidase, M16
EP13_06870	COG4221	oxidoreductase activity
EP13_06875	COG0753	catalase activity
EP13_06880	COG3038	cytochrome b561
EP13_06885	COG0583	DNA-binding transcription factor activity
EP13_06935	COG3008	intermembrane lipid transfer
EP13_06935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP13_06940	COG2995	paraquat-inducible protein a
EP13_06960	COG3093	addiction module antidote protein HigA
EP13_06965	COG0789	Transcriptional regulator
EP13_07005	COG0017	Asparaginyl-tRNA synthetase
EP13_07020	COG0189	ligase activity
EP13_07065	COG3340	Belongs to the peptidase S51 family
EP13_07070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP13_07075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EP13_07085	COG1131	(ABC) transporter
EP13_07105	COG5265	(ABC) transporter
EP13_07110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP13_07140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP13_07180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_07185	COG0402	S-adenosylhomocysteine deaminase activity
EP13_07205	COG2755	lipolytic protein G-D-S-L family
EP13_07210	COG4181	ATPase activity
EP13_07215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EP13_07220	COG1090	epimerase
EP13_07225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EP13_07230	COG0628	permease
EP13_07235	COG2205	protein histidine kinase activity
EP13_07240	COG0745	RESPONSE REGULATOR receiver
EP13_07255	COG2350	Protein conserved in bacteria
EP13_07270	COG0134	indole-3-glycerol-phosphate synthase activity
EP13_07270	COG0135	phosphoribosylanthranilate isomerase activity
EP13_07275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP13_07285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP13_07290	COG0613	PHP domain protein
EP13_07295	COG0009	L-threonylcarbamoyladenylate synthase
EP13_07300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP13_07305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP13_07315	COG0656	L-ascorbic acid biosynthetic process
EP13_07320	COG0110	maltose O-acetyltransferase activity
EP13_07335	COG2733	membrane
EP13_07340	COG0500	methyltransferase
EP13_07345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_07350	COG0497	DNA recombination
EP13_07360	COG0783	Belongs to the Dps family
EP13_07370	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_07385	COG2610	gluconate transmembrane transporter activity
EP13_07390	COG4771	TonB-dependent receptor
EP13_07405	COG2202	Pas domain
EP13_07405	COG2205	protein histidine kinase activity
EP13_07410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP13_07420	COG0484	heat shock protein binding
EP13_07425	COG3909	cytochrome
EP13_07430	COG5001	Diguanylate cyclase
EP13_07430	COG3300	MHYT domain
EP13_07440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP13_07450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP13_07455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP13_07470	COG0071	Belongs to the small heat shock protein (HSP20) family
EP13_07475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EP13_07480	COG0857	belongs to the CobB CobQ family
EP13_07480	COG0280	phosphate acetyltransferase
EP13_07485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP13_07490	COG4535	Mg2 and Co2 transporter CorC
EP13_07495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP13_07515	COG1702	phosphate starvation-inducible protein PhoH
EP13_07525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_07555	COG1607	acyl-coa hydrolase
EP13_07560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP13_07565	COG1115	amino acid carrier protein
EP13_07625	COG0012	GTP binding
EP13_07655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP13_07665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP13_07670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP13_07675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EP13_07685	COG2890	protein-(glutamine-N5) methyltransferase activity
EP13_07690	COG0784	Response regulator, receiver
EP13_07690	COG3437	response regulator, receiver
EP13_07695	COG3094	Invasion gene expression up-regulator, SirB
EP13_07710	COG0583	DNA-binding transcription factor activity
EP13_07720	COG2363	Small membrane protein
EP13_07740	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EP13_07745	COG0515	serine threonine protein kinase
EP13_07745	COG2815	serine threonine protein kinase
EP13_07750	COG2116	formate transmembrane transporter activity
EP13_07755	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EP13_07760	COG0033	Phosphoglucomutase
EP13_07765	COG0058	SHG alpha-glucan phosphorylase activity
EP13_07775	COG2988	succinylglutamate desuccinylase activity
EP13_07805	COG1393	Belongs to the ArsC family
EP13_07855	COG5002	protein histidine kinase activity
EP13_07855	COG5001	Diguanylate cyclase
EP13_07855	COG3447	MASE1 domain protein
EP13_07865	COG0402	S-adenosylhomocysteine deaminase activity
EP13_07870	COG2351	hydroxyisourate hydrolase activity
EP13_07885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP13_07910	COG2252	PERMEase
EP13_07925	COG5001	Diguanylate cyclase
EP13_07925	COG3300	MHYT domain
EP13_07930	COG0745	RESPONSE REGULATOR receiver
EP13_07930	COG3706	GGDEF domain
EP13_07935	COG2205	protein histidine kinase activity
EP13_07935	COG0784	Response regulator, receiver
EP13_07980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP13_07985	COG0730	response to heat
EP13_08025	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_08040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP13_08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP13_08065	COG1596	polysaccharide export
EP13_08070	COG0489	protein tyrosine kinase activity
EP13_08075	COG4464	protein tyrosine phosphatase activity
EP13_08085	COG0438	transferase activity, transferring glycosyl groups
EP13_08100	COG3300	MHYT domain
EP13_08100	COG5001	Diguanylate cyclase
EP13_08125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP13_08125	COG2755	lipolytic protein G-D-S-L family
EP13_08150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP13_08155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP13_08180	COG0072	phenylalanine-tRNA ligase activity
EP13_08180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_08205	COG1472	Belongs to the glycosyl hydrolase 3 family
EP13_08210	COG2096	Adenosyltransferase
EP13_08220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP13_08230	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP13_08235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP13_08245	COG0708	Exodeoxyribonuclease III
EP13_08280	COG2814	Major facilitator Superfamily
EP13_08310	COG0439	Biotin carboxylase
EP13_08320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP13_08325	COG1960	acyl-CoA dehydrogenase activity
EP13_08330	COG0789	Transcriptional regulator
EP13_08335	COG0183	Belongs to the thiolase family
EP13_08350	COG2925	Exonuclease
EP13_08390	COG1643	Atp-dependent helicase
EP13_08410	COG0604	alcohol dehydrogenase
EP13_08410	COG3321	synthase
EP13_08415	COG0328	RNA-DNA hybrid ribonuclease activity
EP13_08420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP13_08450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EP13_08460	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP13_08475	COG3724	N-succinylarginine dihydrolase activity
EP13_08480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP13_08485	COG3122	Protein conserved in bacteria
EP13_08490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP13_08495	COG2153	protein acetylation
EP13_08510	COG1530	ribonuclease E activity
EP13_08515	COG0564	pseudouridine synthase activity
EP13_08530	COG1399	metal-binding, possibly nucleic acid-binding protein
EP13_08540	COG0416	fatty acid biosynthetic process
EP13_08545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP13_08560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP13_08565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP13_08575	COG0596	Alpha beta hydrolase
EP13_08580	COG1024	Enoyl-CoA hydratase
EP13_08580	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_08585	COG0183	Belongs to the thiolase family
EP13_08590	COG1960	acyl-CoA dehydrogenase activity
EP13_08600	COG2390	Transcriptional regulator
EP13_08605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_08640	COG0668	transmembrane transport
EP13_08645	COG4771	TonB-dependent receptor
EP13_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_08670	COG2205	protein histidine kinase activity
EP13_08675	COG3437	response regulator, receiver
EP13_08685	COG0195	Participates in both transcription termination and antitermination
EP13_08700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP13_08725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_08725	COG3153	acetyltransferase
EP13_08755	COG0450	alkyl hydroperoxide reductase
EP13_08810	COG4771	TonB-dependent receptor
EP13_08815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_08825	COG4134	Bacterial extracellular solute-binding protein
EP13_08835	COG4136	ATPase activity
EP13_08840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP13_08850	COG3932	Exopolysaccharide synthesis, ExoD
EP13_08905	COG1131	(ABC) transporter
EP13_08935	COG2867	negative regulation of translational initiation
EP13_08940	COG2914	Belongs to the UPF0125 (RnfH) family
EP13_08950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP13_08955	COG4771	TonB-dependent receptor
EP13_08960	COG0457	Tetratricopeptide repeat
EP13_08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP13_08970	COG0574	Belongs to the PEP-utilizing enzyme family
EP13_08990	COG0277	FAD linked oxidase domain protein
EP13_08990	COG0247	lactate metabolic process
EP13_09000	COG2850	peptidyl-arginine hydroxylation
EP13_09010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP13_09015	COG2915	High frequency lysogenization protein hflD homolog
EP13_09020	COG0482	sulfurtransferase activity
EP13_09025	COG1187	pseudouridine synthase activity
EP13_09035	COG1278	Cold shock
EP13_09040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP13_09045	COG0542	response to heat
EP13_09050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP13_09055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EP13_09060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP13_09065	COG0492	ferredoxin-NADP+ reductase activity
EP13_09070	COG3092	negative regulation of chromosome organization
EP13_09075	COG3091	SprT-like family
EP13_09080	COG0616	signal peptide processing
EP13_09090	COG0778	Nitroreductase
EP13_09100	COG0252	asparaginase activity
EP13_09105	COG3706	GGDEF domain
EP13_09110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP13_09115	COG0321	lipoyl(octanoyl) transferase activity
EP13_09120	COG2921	Belongs to the UPF0250 family
EP13_09125	COG1686	Belongs to the peptidase S11 family
EP13_09130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP13_09135	COG0772	Belongs to the SEDS family
EP13_09140	COG0768	penicillin binding
EP13_09145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP13_09150	COG0799	negative regulation of ribosome biogenesis
EP13_09155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP13_09160	COG1466	dna polymerase III delta subunit
EP13_09165	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EP13_09170	COG0495	leucyl-tRNA aminoacylation
EP13_09175	COG1067	ATP-dependent peptidase activity
EP13_09185	COG1534	Rna-binding protein
EP13_09190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP13_09195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP13_09200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP13_09205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP13_09210	COG0149	triose-phosphate isomerase activity
EP13_09215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP13_09255	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_09270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_09300	COG1185	polyribonucleotide nucleotidyltransferase activity
EP13_09325	COG0295	cytidine deaminase activity
EP13_09340	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EP13_09345	COG1196	nuclear chromosome segregation
EP13_09355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP13_09370	COG1132	(ABC) transporter
EP13_09520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP13_09525	COG0435	Glutathione S-transferase
EP13_09545	COG2009	succinate dehydrogenase
EP13_09550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EP13_09555	COG1053	succinate dehydrogenase
EP13_09560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP13_09565	COG0567	Dehydrogenase, E1 component
EP13_09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP13_09610	COG4667	esterase of the alpha-beta hydrolase superfamily
EP13_09625	COG0366	Alpha amylase catalytic
EP13_09650	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_09655	COG2267	carboxylic ester hydrolase activity
EP13_09665	COG0616	signal peptide processing
EP13_09675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP13_09680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP13_09690	COG0386	Belongs to the glutathione peroxidase family
EP13_09695	COG2084	Dehydrogenase
EP13_09715	COG1960	acyl-CoA dehydrogenase activity
EP13_09720	COG1024	Enoyl-CoA hydratase
EP13_09730	COG2226	methyltransferase
EP13_09735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP13_09740	COG3083	sulfuric ester hydrolase activity
EP13_09745	COG3082	Protein of unknown function (DUF1414)
EP13_09750	COG3081	Nucleoid-associated protein
EP13_09780	COG3275	phosphorelay sensor kinase activity
EP13_09785	COG3279	Response regulator of the LytR AlgR family
EP13_09790	COG0205	6-phosphofructokinase activity
EP13_09815	COG2205	protein histidine kinase activity
EP13_09815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_09850	COG0513	Belongs to the DEAD box helicase family
EP13_09860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP13_09865	COG0583	DNA-binding transcription factor activity
EP13_09895	COG1760	l-serine dehydratase
EP13_09915	COG1322	Protein conserved in bacteria
EP13_09920	COG3706	GGDEF domain
EP13_09930	COG1404	Belongs to the peptidase S8 family
EP13_09940	COG0022	dehydrogenase e1 component
EP13_09950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP13_09955	COG0515	serine threonine protein kinase
EP13_09960	COG1946	Acyl-CoA thioesterase
EP13_09970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP13_09980	COG1956	GAF domain-containing protein
EP13_09995	COG0793	Belongs to the peptidase S41A family
EP13_10000	COG0733	neurotransmitter:sodium symporter activity
EP13_10010	COG0308	aminopeptidase N
EP13_10045	COG0167	dihydroorotate dehydrogenase activity
EP13_10070	COG3130	regulation of translation
EP13_10075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP13_10085	COG0415	Belongs to the DNA photolyase family
EP13_10095	COG0415	Belongs to the DNA photolyase family
EP13_10100	COG3046	protein related to deoxyribodipyrimidine photolyase
EP13_10120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP13_10125	COG0589	response to stress
EP13_10135	COG0069	glutamate synthase activity
EP13_10150	COG2193	ferroxidase activity
EP13_10160	COG3278	Belongs to the heme-copper respiratory oxidase family
EP13_10175	COG2010	Cytochrome c
EP13_10200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP13_10205	COG0589	response to stress
EP13_10210	COG0037	tRNA processing
EP13_10215	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP13_10235	COG1280	lysine exporter protein (LysE YggA)
EP13_10240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP13_10245	COG2897	thiosulfate sulfurtransferase activity
EP13_10250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP13_10335	COG0582	viral genome integration into host DNA
EP13_10360	COG0322	excinuclease ABC activity
EP13_10365	COG2197	response regulator
EP13_10370	COG1741	Belongs to the pirin family
EP13_10390	COG3384	dioxygenase
EP13_10395	COG2259	Doxx family
EP13_10400	COG0583	DNA-binding transcription factor activity
EP13_10415	COG0670	Belongs to the BI1 family
EP13_10420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP13_10435	COG2920	part of a sulfur-relay system
EP13_10440	COG0561	phosphatase activity
EP13_10470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP13_10475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP13_10480	COG1674	ftsk spoiiie
EP13_10480	COG0531	amino acid
EP13_10490	COG0686	Belongs to the AlaDH PNT family
EP13_10495	COG0284	orotidine-5'-phosphate decarboxylase activity
EP13_10500	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EP13_10515	COG0776	regulation of translation
EP13_10520	COG0539	negative regulation of cytoplasmic translation
EP13_10525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP13_10530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP13_10535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP13_10550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP13_10555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP13_10560	COG0633	Ferredoxin
EP13_10600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EP13_10605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP13_10615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP13_10625	COG4783	chaperone-mediated protein folding
EP13_10630	COG4232	protein-disulfide reductase activity
EP13_10635	COG1393	Belongs to the ArsC family
EP13_10665	COG0024	Methionine aminopeptidase
EP13_10685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP13_10700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP13_10710	COG1960	acyl-CoA dehydrogenase activity
EP13_10735	COG3769	mannosylglycerate metabolic process
EP13_10740	COG1215	transferase activity, transferring glycosyl groups
EP13_10755	COG0303	'Molybdopterin
EP13_10760	COG0534	Mate efflux family protein
EP13_10775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP13_10780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP13_10790	COG0405	Gamma-glutamyltransferase
EP13_10795	COG1024	Enoyl-CoA hydratase
EP13_10835	COG1448	Aminotransferase
EP13_10845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EP13_10855	COG1671	Belongs to the UPF0178 family
EP13_10860	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_10865	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_10870	COG1960	acyl-CoA dehydrogenase activity
EP13_10875	COG4977	sequence-specific DNA binding
EP13_10935	COG0596	Alpha beta hydrolase
EP13_10945	COG0716	FMN binding
EP13_10955	COG0735	belongs to the Fur family
EP13_10965	COG1984	allophanate hydrolase subunit 2
EP13_10975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EP13_10980	COG2996	Protein conserved in bacteria
EP13_11000	COG0436	Aminotransferase
EP13_11005	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EP13_11010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP13_11025	COG4771	TonB-dependent receptor
EP13_11030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EP13_11040	COG1238	metal cluster binding
EP13_11050	COG3012	SEC-C Motif Domain Protein
EP13_11065	COG0456	acetyltransferase
EP13_11070	COG3706	GGDEF domain
EP13_11075	COG0702	epimerase
EP13_11085	COG0084	hydrolase, TatD family'
EP13_11100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP13_11135	COG4771	TonB-dependent receptor
EP13_11150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP13_11175	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP13_11185	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP13_11190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP13_11210	COG0436	Aminotransferase
EP13_11215	COG3268	Saccharopine dehydrogenase
EP13_11220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_11245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP13_11255	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EP13_11270	COG1022	Amp-dependent synthetase and ligase
EP13_11285	COG3132	Protein of unknown function, DUF480
EP13_11300	COG0583	DNA-binding transcription factor activity
EP13_11315	COG3085	chromosome segregation
EP13_11325	COG0640	Transcriptional regulator
EP13_11345	COG2204	response regulator
EP13_11355	COG4251	negative regulation of phosphorylation
EP13_11360	COG0784	Response regulator, receiver
EP13_11410	COG3139	Protein of unknown function (DUF1315)
EP13_11420	COG1115	amino acid carrier protein
EP13_11425	COG2866	Carboxypeptidase
EP13_11450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP13_11460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP13_11465	COG1640	4-alpha-glucanotransferase
EP13_11475	COG0676	glucose-6-phosphate 1-epimerase activity
EP13_11485	COG0800	Aldolase
EP13_11490	COG0837	glucose binding
EP13_11495	COG0129	dihydroxy-acid dehydratase activity
EP13_11505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP13_11510	COG1737	Transcriptional regulator
EP13_11515	COG0469	pyruvate kinase activity
EP13_11520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP13_11565	COG2205	protein histidine kinase activity
EP13_11570	COG0745	RESPONSE REGULATOR receiver
EP13_11595	COG3665	Urea carboxylase-associated protein
EP13_11605	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_11610	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EP13_11635	COG2721	sulfolactate sulfo-lyase activity
EP13_11640	COG1904	glucuronate isomerase
EP13_11645	COG0246	Mannitol dehydrogenase
EP13_11650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_11655	COG2755	lipolytic protein G-D-S-L family
EP13_11665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP13_11675	COG4677	pectinesterase activity
EP13_11680	COG0784	Response regulator, receiver
EP13_11680	COG2205	protein histidine kinase activity
EP13_11680	COG5002	protein histidine kinase activity
EP13_11690	COG0308	aminopeptidase N
EP13_11695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_11705	COG1119	ATPase activity
EP13_11720	COG1609	Transcriptional regulator
EP13_11725	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_11745	COG3300	MHYT domain
EP13_11745	COG5001	Diguanylate cyclase
EP13_11765	COG0745	RESPONSE REGULATOR receiver
EP13_11770	COG2205	protein histidine kinase activity
EP13_11780	COG0784	Response regulator, receiver
EP13_11780	COG3437	response regulator, receiver
EP13_11785	COG4191	Histidine kinase
EP13_11785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_11825	COG0330	HflC and HflK could
EP13_11845	COG0471	metal ion transport
EP13_11855	COG0489	protein tyrosine kinase activity
EP13_11860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_11860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP13_11865	COG2226	methyltransferase
EP13_11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP13_11875	COG0741	lytic transglycosylase activity
EP13_11875	COG1388	LysM domain
EP13_11890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP13_11900	COG1785	Belongs to the alkaline phosphatase family
EP13_11905	COG1785	Belongs to the alkaline phosphatase family
EP13_11920	COG2268	Band 7 protein
EP13_11930	COG0583	DNA-binding transcription factor activity
EP13_11935	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EP13_11950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EP13_11955	COG1286	toxin biosynthetic process
EP13_11960	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EP13_11965	COG0285	dihydrofolate synthase activity
EP13_11990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP13_12000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP13_12005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EP13_12005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP13_12030	COG0668	transmembrane transport
EP13_12035	COG5002	protein histidine kinase activity
EP13_12035	COG2205	protein histidine kinase activity
EP13_12035	COG0784	Response regulator, receiver
EP13_12050	COG3101	peptidyl-lysine hydroxylation
EP13_12070	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP13_12070	COG1902	pentaerythritol trinitrate reductase activity
EP13_12095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP13_12105	COG4399	Belongs to the UPF0754 family
EP13_12135	COG2186	Transcriptional regulator
EP13_12145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EP13_12150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP13_12155	COG2983	Belongs to the UPF0260 family
EP13_12160	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP13_12175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP13_12180	COG0318	PFAM AMP-dependent synthetase and ligase
EP13_12185	COG2267	carboxylic ester hydrolase activity
EP13_12200	COG1214	PFAM Peptidase M22, glycoprotease
EP13_12205	COG1199	ATP-dependent helicase activity
EP13_12235	COG4771	TonB-dependent receptor
EP13_12245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP13_12250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP13_12255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_12260	COG0131	Imidazoleglycerol-phosphate dehydratase
EP13_12260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP13_12265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EP13_12295	COG2116	formate transmembrane transporter activity
EP13_12310	COG4206	TonB-dependent receptor
EP13_12330	COG0326	Molecular chaperone. Has ATPase activity
EP13_12335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP13_12355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP13_12360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP13_12370	COG3220	belongs to the UPF0276 family
EP13_12380	COG4249	Peptidase C14 caspase catalytic subunit p20
EP13_12380	COG2319	Wd-40 repeat
EP13_12395	COG4251	negative regulation of phosphorylation
EP13_12395	COG5001	Diguanylate cyclase
EP13_12395	COG3706	GGDEF domain
EP13_12395	COG2203	Gaf domain
EP13_12425	COG1183	phosphatidylcholine synthase activity
EP13_12445	COG0542	response to heat
EP13_12455	COG0564	pseudouridine synthase activity
EP13_12470	COG1595	DNA-templated transcription, initiation
EP13_12485	COG4221	oxidoreductase activity
EP13_12500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP13_12510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP13_12520	COG0142	geranyltranstransferase activity
EP13_12530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP13_12545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP13_12560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP13_12560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP13_12575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP13_12580	COG0488	(ABC) transporter
EP13_12590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP13_12600	COG0560	Phosphoserine phosphatase
EP13_12610	COG0084	hydrolase, TatD family'
EP13_12630	COG0681	Belongs to the peptidase S26 family
EP13_12655	COG1595	DNA-templated transcription, initiation
EP13_12660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EP13_12675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EP13_12755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP13_12760	COG1047	Peptidyl-prolyl cis-trans
EP13_12770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP13_12775	COG0196	riboflavin kinase activity
EP13_12780	COG0728	peptidoglycan biosynthetic process
EP13_12785	COG0268	Binds directly to 16S ribosomal RNA
EP13_12815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_12820	COG0776	regulation of translation
EP13_12825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP13_12830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP13_12835	COG0740	serine-type endopeptidase activity
EP13_12840	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP13_12880	COG1720	tRNA m6t6A37 methyltransferase activity
EP13_12900	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP13_12915	COG0517	IMP dehydrogenase activity
EP13_12915	COG0516	GMP reductase activity
EP13_12920	COG1570	exodeoxyribonuclease VII activity
EP13_12935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP13_12940	COG2976	Protein conserved in bacteria
EP13_12955	COG1426	Protein conserved in bacteria
EP13_12965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP13_12975	COG2166	iron-sulfur cluster assembly
EP13_12990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP13_12995	COG0719	Fe-S assembly protein
EP13_13000	COG0396	ATPase activity
EP13_13005	COG0719	Fe-S assembly protein
EP13_13010	COG1104	cysteine desulfurase activity
EP13_13020	COG1045	serine acetyltransferase
EP13_13025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EP13_13030	COG0483	inositol monophosphate 1-phosphatase activity
EP13_13045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP13_13050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP13_13055	COG1862	Preprotein translocase
EP13_13060	COG0343	queuine tRNA-ribosyltransferase activity
EP13_13080	COG1842	Phage shock protein A
EP13_13085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP13_13105	COG0754	glutathionylspermidine amidase activity
EP13_13120	COG2066	Belongs to the glutaminase family
EP13_13125	COG1785	Belongs to the alkaline phosphatase family
EP13_13195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP13_13230	COG0367	asparagine synthase
EP13_13330	COG0489	protein tyrosine kinase activity
EP13_13340	COG3267	Type II secretory pathway component ExeA
EP13_13340	COG3409	Peptidoglycan-binding domain 1 protein
EP13_13350	COG2827	Endonuclease containing a URI domain
EP13_13370	COG1560	Kdo2-lipid A biosynthetic process
EP13_13380	COG1960	acyl-CoA dehydrogenase activity
EP13_13400	COG1435	thymidine kinase activity
EP13_13405	COG1609	Transcriptional regulator
EP13_13410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP13_13445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EP13_13450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP13_13475	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP13_13475	COG1024	Enoyl-CoA hydratase
EP13_13490	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EP13_13510	COG1960	acyl-CoA dehydrogenase activity
EP13_13535	COG2080	2 iron, 2 sulfur cluster binding
EP13_13540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EP13_13545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP13_13565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP13_13595	COG0583	DNA-binding transcription factor activity
EP13_13600	COG0523	cobalamin synthesis protein
EP13_13625	COG0693	protein deglycase activity
EP13_13640	COG0583	DNA-binding transcription factor activity
EP13_13645	COG2233	PERMEase
EP13_13650	COG0402	S-adenosylhomocysteine deaminase activity
EP13_13660	COG1595	DNA-templated transcription, initiation
EP13_13705	COG1295	ribonuclease BN
EP13_13710	COG2197	response regulator
EP13_13780	COG4681	YaeQ
EP13_13830	COG0514	ATP-dependent DNA helicase (RecQ)
EP13_13835	COG2267	carboxylic ester hydrolase activity
EP13_13855	COG0784	Response regulator, receiver
EP13_13855	COG2205	protein histidine kinase activity
EP13_13855	COG5002	protein histidine kinase activity
EP13_13860	COG1595	DNA-templated transcription, initiation
EP13_13870	COG1764	response to oxidative stress
EP13_13875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP13_13880	COG3437	response regulator, receiver
EP13_13880	COG3850	Histidine kinase
EP13_13880	COG2205	protein histidine kinase activity
EP13_13880	COG4999	Histidine kinase
EP13_13890	COG4555	ABC transporter
EP13_13905	COG0513	Belongs to the DEAD box helicase family
EP13_13920	COG0235	Class ii aldolase
EP13_13935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP13_13940	COG0577	efflux transmembrane transporter activity
EP13_13940	COG1136	(ABC) transporter
EP13_13945	COG0577	efflux transmembrane transporter activity
EP13_13945	COG1136	(ABC) transporter
EP13_13960	COG3852	Histidine kinase
EP13_14035	COG1609	Transcriptional regulator
EP13_14045	COG2971	BadF BadG BcrA BcrD
EP13_14050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP13_14055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EP13_14065	COG0583	DNA-binding transcription factor activity
EP13_14070	COG0006	proline dipeptidase activity
EP13_14080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_14085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP13_14090	COG0006	proline dipeptidase activity
EP13_14100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_14105	COG1957	nucleoside hydrolase
EP13_14110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP13_14115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP13_14120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP13_14140	COG3313	Fe-S protein
EP13_14160	COG4948	Mandelate Racemase Muconate Lactonizing
EP13_14175	COG0546	phosphoglycolate phosphatase activity
EP13_14185	COG3962	Belongs to the TPP enzyme family
EP13_14200	COG3718	enzyme involved in inositol metabolism
EP13_14215	COG1904	glucuronate isomerase
EP13_14230	COG0673	inositol 2-dehydrogenase activity
EP13_14240	COG1175	transmembrane transport
EP13_14245	COG0395	ABC-type sugar transport system, permease component
EP13_14255	COG4771	TonB-dependent receptor
EP13_14295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_14300	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP13_14305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP13_14315	COG2186	Transcriptional regulator
EP13_14330	COG3577	Aspartyl protease
EP13_14340	COG4969	Belongs to the N-Me-Phe pilin family
EP13_14345	COG1459	type II secretion system
EP13_14350	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP13_14355	COG0237	dephospho-CoA kinase activity
EP13_14360	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EP13_14365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP13_14385	COG1621	beta-fructofuranosidase activity
EP13_14390	COG2814	Major facilitator Superfamily
EP13_14400	COG1629	transport
EP13_14400	COG4206	TonB-dependent receptor
EP13_14405	COG3608	succinylglutamate desuccinylase aspartoacylase
EP13_14420	COG0739	heme binding
EP13_14425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP13_14430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP13_14435	COG0849	cell division
EP13_14440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP13_14445	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP13_14450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP13_14460	COG0772	Belongs to the SEDS family
EP13_14465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP13_14475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP13_14480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP13_14485	COG0768	penicillin binding
EP13_14490	COG3116	cell division
EP13_14500	COG2001	Belongs to the MraZ family
EP13_14515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP13_14540	COG0678	peroxiredoxin activity
EP13_14540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP13_14555	COG2356	endonuclease I
EP13_14560	COG2204	response regulator
EP13_14575	COG2084	Dehydrogenase
EP13_14580	COG2271	Major facilitator Superfamily
EP13_14610	COG0668	transmembrane transport
EP13_14620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP13_14635	COG1678	Uncharacterized ACR, COG1678
EP13_14640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP13_14660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP13_14665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EP13_14670	COG0762	integral membrane protein
EP13_14680	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP13_14680	COG1902	pentaerythritol trinitrate reductase activity
EP13_14710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP13_14745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP13_14750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP13_14765	COG0583	DNA-binding transcription factor activity
EP13_14780	COG0640	Transcriptional regulator
EP13_14790	COG0431	NADPH-dependent FMN reductase
EP13_14795	COG0798	PFAM Bile acid sodium symporter
EP13_14800	COG2201	protein-glutamate methylesterase activity
EP13_14805	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EP13_14830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP13_14840	COG1748	Saccharopine dehydrogenase
EP13_14855	COG3706	GGDEF domain
EP13_14860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EP13_14870	COG0792	nuclease activity
EP13_14880	COG2823	Periplasmic or secreted lipoprotein
EP13_14905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EP13_14910	COG0372	Belongs to the citrate synthase family
EP13_14915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP13_14920	COG2828	Protein conserved in bacteria
EP13_14925	COG2203	Gaf domain
EP13_14925	COG2199	diguanylate cyclase activity
EP13_14945	COG2198	Histidine kinase
EP13_14945	COG0784	Response regulator, receiver
EP13_14945	COG5002	protein histidine kinase activity
EP13_14950	COG3023	N-Acetylmuramoyl-L-alanine amidase
EP13_14960	COG0070	glutamate synthase
EP13_14960	COG0069	glutamate synthase activity
EP13_14960	COG0067	glutamate synthase
EP13_14965	COG0493	'glutamate synthase
EP13_14980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP13_15015	COG1304	FMN binding
EP13_15020	COG4952	isomerase
EP13_15025	COG3347	Dehydrogenase
EP13_15025	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_15040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_15050	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_15065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EP13_15080	COG3254	rhamnose metabolic process
EP13_15095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP13_15105	COG5507	3-demethylubiquinone-9 3-methyltransferase
EP13_15115	COG0741	lytic transglycosylase activity
EP13_15115	COG0739	heme binding
EP13_15115	COG1196	nuclear chromosome segregation
EP13_15120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP13_15125	COG3437	response regulator, receiver
EP13_15140	COG1902	pentaerythritol trinitrate reductase activity
EP13_15155	COG0625	glutathione transferase activity
EP13_15185	COG2894	cell division
EP13_15190	COG0850	regulation of cytokinetic process
EP13_15235	COG1914	H( )-stimulated, divalent metal cation uptake system
EP13_15260	COG0174	glutamine synthetase
EP13_15270	COG3852	Histidine kinase
EP13_15275	COG2204	response regulator
EP13_15280	COG3437	response regulator, receiver
EP13_15285	COG0204	Acyl-transferase
EP13_15300	COG3706	GGDEF domain
EP13_15310	COG0784	Response regulator, receiver
EP13_15310	COG5002	protein histidine kinase activity
EP13_15310	COG2205	protein histidine kinase activity
EP13_15315	COG0525	valine-tRNA ligase activity
EP13_15320	COG2927	DNA polymerase III (CHI subunit)
EP13_15325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP13_15330	COG0795	lipopolysaccharide-transporting ATPase activity
EP13_15335	COG0795	lipopolysaccharide-transporting ATPase activity
EP13_15365	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_15375	COG3246	L-lysine catabolic process to acetate
EP13_15430	COG1131	(ABC) transporter
EP13_15445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EP13_15460	COG0535	radical SAM domain protein
EP13_15495	COG0784	Response regulator, receiver
EP13_15495	COG2205	protein histidine kinase activity
EP13_15505	COG0348	domain, Protein
EP13_15505	COG3901	Regulator of nitric oxide reductase transcription
EP13_15515	COG2197	response regulator
EP13_15520	COG4585	Histidine kinase
EP13_15555	COG0793	Belongs to the peptidase S41A family
EP13_15555	COG4946	Tricorn protease homolog
EP13_15610	COG3209	COG3209 Rhs family protein
EP13_15615	COG4206	TonB-dependent receptor
EP13_15625	COG4139	cobalamin transport
EP13_15630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP13_15635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP13_15645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP13_15655	COG1028	Short-chain dehydrogenase reductase Sdr
EP13_15675	COG1609	Transcriptional regulator
EP13_15695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP13_15730	COG2267	carboxylic ester hydrolase activity
EP13_15745	COG1116	anion transmembrane transporter activity
EP13_15770	COG0513	Belongs to the DEAD box helicase family
EP13_15775	COG0800	Aldolase
EP13_15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP13_15795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP13_15795	COG3264	Mechanosensitive ion channel
EP13_15820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP13_15820	COG0475	glutathione-regulated potassium exporter activity
EP13_15835	COG3568	Endonuclease Exonuclease Phosphatase
EP13_15850	COG0730	response to heat
EP13_15855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP13_15870	COG4191	Histidine kinase
EP13_15875	COG0417	DNA replication proofreading
EP13_15935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_15945	COG1573	uracil-dna glycosylase
EP13_15970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP13_15995	COG1842	Phage shock protein A
EP13_16010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_16015	COG4529	Protein conserved in bacteria
EP13_16045	COG0204	Acyl-transferase
EP13_16050	COG0204	Acyl-transferase
EP13_16055	COG0668	transmembrane transport
EP13_16070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP13_16075	COG0733	neurotransmitter:sodium symporter activity
EP13_16090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP13_16105	COG0716	FMN binding
EP13_16115	COG0848	biopolymer transport protein
EP13_16130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EP13_16150	COG5002	protein histidine kinase activity
EP13_16150	COG5001	Diguanylate cyclase
EP13_16160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP13_16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP13_16175	COG0583	DNA-binding transcription factor activity
EP13_16195	COG0121	glutamine amidotransferase
EP13_16220	COG1522	sequence-specific DNA binding
EP13_16230	COG0577	efflux transmembrane transporter activity
EP13_16230	COG1136	(ABC) transporter
EP13_16245	COG4628	conserved protein (DUF2132)
EP13_16255	COG3265	gluconokinase activity
EP13_16260	COG1609	Transcriptional regulator
EP13_16275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP13_16285	COG1477	protein flavinylation
EP13_16290	COG2871	sodium ion transport
EP13_16295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_16300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_16305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_16310	COG1805	sodium ion transport
EP13_16315	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EP13_16320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP13_16325	COG0545	Peptidyl-prolyl cis-trans isomerase
EP13_16330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP13_16350	COG0039	L-malate dehydrogenase activity
EP13_16355	COG1438	arginine binding
EP13_16360	COG4206	TonB-dependent receptor
EP13_16385	COG0572	uridine kinase
EP13_16390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EP13_16410	COG0517	IMP dehydrogenase activity
EP13_16410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EP13_16415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_16425	COG0784	Response regulator, receiver
EP13_16425	COG5002	protein histidine kinase activity
EP13_16425	COG2198	Histidine kinase
EP13_16435	COG0189	ligase activity
EP13_16445	COG4067	protein conserved in archaea
EP13_16445	COG0189	ligase activity
EP13_16460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP13_16470	COG1283	sodium-dependent phosphate transmembrane transporter activity
EP13_16475	COG0667	Aldo Keto reductase
EP13_16490	COG0753	catalase activity
EP13_16550	COG0583	DNA-binding transcription factor activity
EP13_16580	COG0438	transferase activity, transferring glycosyl groups
EP13_16580	COG1216	Glycosyl transferase, family 2
EP13_16590	COG1091	dTDP-4-dehydrorhamnose reductase activity
EP13_16610	COG1216	Glycosyl transferase, family 2
EP13_16640	COG1215	transferase activity, transferring glycosyl groups
EP13_16650	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EP13_16650	COG0662	Cupin 2, conserved barrel domain protein
EP13_16660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP13_16670	COG0202	RNA polymerase activity
EP13_16690	COG0201	protein transport
EP13_16710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP13_16745	COG5002	protein histidine kinase activity
EP13_16745	COG0784	Response regulator, receiver
EP13_16775	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EP13_16805	COG2234	aminopeptidase activity
EP13_16845	COG1271	oxidase subunit
EP13_16850	COG1294	oxidase, subunit
EP13_16860	COG0840	transmembrane signaling receptor activity
EP13_16870	COG1278	Cold shock
EP13_16875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP13_16895	COG0339	signal peptide processing
EP13_16900	COG0745	RESPONSE REGULATOR receiver
EP13_16910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP13_16910	COG4191	Histidine kinase
EP13_16925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP13_16930	COG0823	Involved in the tonB-independent uptake of proteins
EP13_16930	COG1506	peptidase
EP13_16930	COG4946	Tricorn protease homolog
EP13_16970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EP13_16975	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP13_16980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP13_16995	COG0281	malic enzyme
EP13_17005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP13_17035	COG0456	acetyltransferase
EP13_17045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_17050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_17055	COG2177	Part of the ABC transporter FtsEX involved in
EP13_17060	COG2884	Cell division ATP-binding protein ftsE
EP13_17065	COG0552	protein localization to endoplasmic reticulum
EP13_17070	COG0742	ribosomal rna small subunit methyltransferase
EP13_17075	COG3068	Protein conserved in bacteria
EP13_17080	COG2095	MarC family integral membrane protein
EP13_17100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP13_17115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP13_17130	COG0076	glutamate decarboxylase activity
EP13_17140	COG0842	Transport permease protein
EP13_17145	COG1131	(ABC) transporter
EP13_17155	COG0745	RESPONSE REGULATOR receiver
EP13_17160	COG2205	protein histidine kinase activity
EP13_17165	COG4774	siderophore transport
EP13_17185	COG1253	flavin adenine dinucleotide binding
EP13_17190	COG0701	Predicted permease
EP13_17195	COG1966	Carbon starvation protein
EP13_17215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP13_17220	COG0049	tRNA binding
EP13_17225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP13_17230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP13_17235	COG0085	RNA polymerase activity
EP13_17240	COG0222	ribosome binding
EP13_17245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP13_17250	COG0081	regulation of translation
EP13_17255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP13_17270	COG0250	Participates in transcription elongation, termination and antitermination
EP13_17275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP13_17285	COG1132	(ABC) transporter
EP13_17290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP13_17300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP13_17305	COG3590	peptidase
EP13_17315	COG0513	Belongs to the DEAD box helicase family
EP13_17320	COG0418	dihydroorotase activity
EP13_17330	COG3040	lipid binding
EP13_17335	COG4989	oxidoreductase activity
EP13_17340	COG0346	lactoylglutathione lyase activity
EP13_17355	COG0302	gtp cyclohydrolase
EP13_17365	COG2957	Belongs to the agmatine deiminase family
EP13_17370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP13_17380	COG3706	GGDEF domain
EP13_17420	COG1201	RNA secondary structure unwinding
EP13_17430	COG1793	dna ligase
EP13_17450	COG0625	glutathione transferase activity
EP13_17460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP13_17470	COG1012	belongs to the aldehyde dehydrogenase family
EP13_17475	COG0028	Belongs to the TPP enzyme family
EP13_17485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP13_17490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EP13_17495	COG0330	HflC and HflK could
EP13_17500	COG0330	HflC and HflK could
EP13_17505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP13_17510	COG1923	regulation of RNA biosynthetic process
EP13_17515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP13_17520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP13_17530	COG0802	atpase or kinase
EP13_17535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP13_17535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EP13_17540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EP13_17550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EP13_17560	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EP13_17565	COG0735	belongs to the Fur family
EP13_17575	COG0432	Pfam Uncharacterised protein family UPF0047
EP13_17585	COG0305	Participates in initiation and elongation during chromosome replication
EP13_17610	COG2258	MOSC domain
EP13_17630	COG5002	protein histidine kinase activity
EP13_17640	COG0840	transmembrane signaling receptor activity
EP13_17645	COG4191	Histidine kinase
EP13_17655	COG1609	Transcriptional regulator
EP13_17660	COG2211	Major facilitator Superfamily
EP13_17665	COG2723	6-phospho-beta-galactosidase activity
EP13_17685	COG0789	Transcriptional regulator
EP13_17700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP13_17720	COG4771	TonB-dependent receptor
EP13_17740	COG3706	GGDEF domain
EP13_17755	COG4890	Cyd operon protein YbgT
EP13_17760	COG1294	oxidase, subunit
EP13_17775	COG2204	response regulator
EP13_17860	COG2814	Major facilitator Superfamily
EP13_17870	COG3237	CsbD-like
EP13_17885	COG4771	TonB-dependent receptor
EP13_17890	COG0457	Tetratricopeptide repeat
EP13_17950	COG2235	arginine
EP13_17970	COG1595	DNA-templated transcription, initiation
EP13_18000	COG2267	carboxylic ester hydrolase activity
EP13_18020	COG1252	NADH dehydrogenase
EP13_18040	COG0583	DNA-binding transcription factor activity
EP13_18045	COG2067	long-chain fatty acid transport protein
EP13_18050	COG2130	NADP-dependent
EP13_18055	COG0745	RESPONSE REGULATOR receiver
EP13_18055	COG3706	GGDEF domain
EP13_18060	COG0784	Response regulator, receiver
EP13_18060	COG2205	protein histidine kinase activity
EP13_18070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP13_18080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP13_18085	COG4771	TonB-dependent receptor
EP13_18090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP13_18110	COG0656	L-ascorbic acid biosynthetic process
EP13_18115	COG2175	clavaminate synthase activity
EP13_18120	COG2855	membrane
EP13_18190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP13_18195	COG1349	DNA-binding transcription factor activity
EP13_18200	COG0673	inositol 2-dehydrogenase activity
EP13_18215	COG0697	spore germination
EP13_18225	COG2169	Transcriptional regulator
EP13_18235	COG1166	arginine decarboxylase activity
EP13_18245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EP13_18250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP13_18255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP13_18275	COG3866	Pectate lyase
EP13_18285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP13_18290	COG3507	Belongs to the glycosyl hydrolase 43 family
EP13_18315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP13_18330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP13_18365	COG1335	isochorismatase
EP13_18370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP13_18385	COG3384	dioxygenase
EP13_18395	COG2175	clavaminate synthase activity
EP13_18420	COG1324	tolerance protein
EP13_18425	COG4232	protein-disulfide reductase activity
EP13_18430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP13_18435	COG0511	ligase activity, forming carbon-carbon bonds
EP13_18440	COG0439	Biotin carboxylase
EP13_18495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP13_18500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EP13_18515	COG0151	Belongs to the GarS family
EP13_18525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP13_18535	COG3954	Phosphoribulokinase
EP13_18545	COG0745	RESPONSE REGULATOR receiver
EP13_18565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP13_18575	COG3031	protein transport across the cell outer membrane
EP13_18585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP13_18590	COG1459	type II secretion system
EP13_18595	COG2165	general secretion pathway protein
EP13_18605	COG2165	general secretion pathway protein
EP13_18610	COG4795	General secretion pathway protein
EP13_18615	COG3156	type II secretion system protein K
EP13_18625	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EP13_18640	COG1012	belongs to the aldehyde dehydrogenase family
EP13_18650	COG1011	Hydrolase
EP13_18655	COG0494	nUDIX hydrolase
EP13_18660	COG1218	3'(2'),5'-bisphosphate nucleotidase
EP13_18670	COG2943	transferase activity, transferring hexosyl groups
EP13_18675	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EP13_18685	COG3089	Belongs to the UPF0270 family
EP13_18690	COG0429	hydrolase of the alpha beta-hydrolase fold
EP13_18700	COG0488	(ABC) transporter
EP13_18725	COG0545	Peptidyl-prolyl cis-trans isomerase
EP13_18735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP13_18740	COG2183	response to ionizing radiation
EP13_18755	COG0596	Alpha beta hydrolase
EP13_18760	COG1040	competence protein
EP13_18780	COG1794	racemase activity, acting on amino acids and derivatives
EP13_18785	COG2226	methyltransferase
EP13_18795	COG0534	Mate efflux family protein
EP13_18815	COG0109	protoheme IX farnesyltransferase activity
EP13_18840	COG1845	cytochrome c oxidase, subunit III
EP13_18850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP13_18855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP13_18865	COG4774	siderophore transport
EP13_18885	COG0129	dihydroxy-acid dehydratase activity
EP13_18890	COG2860	membrane
EP13_18895	COG0606	chelatase, subunit chli
EP13_18900	COG0583	DNA-binding transcription factor activity
EP13_18910	COG2814	Major facilitator Superfamily
EP13_18920	COG0729	surface antigen
EP13_18945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP13_18955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP13_18975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP13_19020	COG0425	Belongs to the sulfur carrier protein TusA family
EP13_19035	COG1561	YicC-like family, N-terminal region
EP13_19050	COG3550	peptidyl-serine autophosphorylation
EP13_19070	COG2723	6-phospho-beta-galactosidase activity
EP13_19075	COG2211	Major facilitator Superfamily
EP13_19125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP13_19150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP13_19170	COG1475	DNA binding
EP13_19175	COG1192	Involved in chromosome partitioning
EP13_19200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP13_19205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP13_19215	COG0706	membrane insertase activity
EP13_19220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane