locus-tag	class	description
EZ55_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZ55_00029	COG2818	Glycosylase
EZ55_00031	COG3078	GTPase activator activity
EZ55_00035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZ55_00035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZ55_00036	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EZ55_00037	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZ55_00038	COG0569	domain protein
EZ55_00039	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZ55_00039	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZ55_00040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZ55_00043	COG0758	DNA mediated transformation
EZ55_00046	COG0009	L-threonylcarbamoyladenylate synthase
EZ55_00047	COG0408	coproporphyrinogen oxidase activity
EZ55_00048	COG3047	cAMP biosynthetic process
EZ55_00052	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EZ55_00069	COG2234	aminopeptidase activity
EZ55_00073	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZ55_00078	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ55_00084	COG3642	lipopolysaccharide core region biosynthetic process
EZ55_00090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZ55_00093	COG3161	chorismate lyase activity
EZ55_00094	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZ55_00096	COG0210	DNA helicase
EZ55_00100	COG1757	Na H antiporter
EZ55_00101	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ55_00110	COG0583	DNA-binding transcription factor activity
EZ55_00112	COG3106	COG3106 Predicted ATPase
EZ55_00116	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZ55_00119	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EZ55_00120	COG0352	thiamine-phosphate diphosphorylase activity
EZ55_00123	COG3071	HemY protein
EZ55_00124	COG2959	enzyme of heme biosynthesis
EZ55_00126	COG0181	hydroxymethylbilane synthase activity
EZ55_00129	COG0194	GDP metabolic process
EZ55_00131	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZ55_00133	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ55_00134	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZ55_00136	COG0678	peroxiredoxin activity
EZ55_00139	COG1178	ABC-type Fe3 transport system permease component
EZ55_00140	COG3842	ATPase activity
EZ55_00141	COG2081	HI0933 family
EZ55_00142	COG3047	cAMP biosynthetic process
EZ55_00145	COG2200	EAL domain
EZ55_00146	COG3706	GGDEF domain
EZ55_00152	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_00155	COG0427	acetyl-CoA hydrolase
EZ55_00156	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZ55_00159	COG0840	transmembrane signaling receptor activity
EZ55_00161	COG3064	Membrane
EZ55_00163	COG5002	protein histidine kinase activity
EZ55_00163	COG5001	Diguanylate cyclase
EZ55_00166	COG0514	ATP-dependent DNA helicase (RecQ)
EZ55_00167	COG2050	protein possibly involved in aromatic compounds catabolism
EZ55_00168	COG2239	Acts as a magnesium transporter
EZ55_00169	COG2962	Rard protein
EZ55_00170	COG3706	GGDEF domain
EZ55_00171	COG0210	DNA helicase
EZ55_00173	COG3706	GGDEF domain
EZ55_00174	COG1011	Hydrolase
EZ55_00175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EZ55_00177	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZ55_00178	COG0019	diaminopimelate decarboxylase activity
EZ55_00185	COG0163	prenyltransferase activity
EZ55_00186	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZ55_00188	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZ55_00195	COG1077	Cell shape determining protein MreB Mrl
EZ55_00197	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZ55_00198	COG2814	Major facilitator Superfamily
EZ55_00199	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ55_00205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EZ55_00207	COG0629	single-stranded DNA binding
EZ55_00211	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZ55_00214	COG1349	DNA-binding transcription factor activity
EZ55_00223	COG3267	Type II secretory pathway component ExeA
EZ55_00223	COG3409	Peptidoglycan-binding domain 1 protein
EZ55_00225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ55_00226	COG1459	type II secretion system
EZ55_00228	COG2165	general secretion pathway protein
EZ55_00229	COG3328	transposase activity
EZ55_00230	COG2165	general secretion pathway protein
EZ55_00236	COG1077	Cell shape determining protein MreB Mrl
EZ55_00237	COG1792	Involved in formation and maintenance of cell shape
EZ55_00238	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EZ55_00240	COG1530	ribonuclease E activity
EZ55_00242	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ55_00243	COG0312	modulator of DNA gyrase
EZ55_00245	COG3028	Belongs to the UPF0307 family
EZ55_00246	COG0312	modulator of DNA gyrase
EZ55_00249	COG0745	RESPONSE REGULATOR receiver
EZ55_00250	COG4191	Histidine kinase
EZ55_00250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ55_00251	COG0297	glycogen (starch) synthase activity
EZ55_00253	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZ55_00274	COG4974	Belongs to the 'phage' integrase family
EZ55_00288	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EZ55_00290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZ55_00292	COG0463	Glycosyl transferase, family 2
EZ55_00294	COG0745	RESPONSE REGULATOR receiver
EZ55_00295	COG5002	protein histidine kinase activity
EZ55_00307	COG0745	RESPONSE REGULATOR receiver
EZ55_00309	COG0835	chemotaxis
EZ55_00312	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EZ55_00315	COG0745	RESPONSE REGULATOR receiver
EZ55_00316	COG0643	Histidine kinase
EZ55_00316	COG2198	Histidine kinase
EZ55_00317	COG0835	chemotaxis
EZ55_00321	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EZ55_00325	COG3385	transposase activity
EZ55_00332	COG0546	phosphoglycolate phosphatase activity
EZ55_00334	COG2205	protein histidine kinase activity
EZ55_00334	COG0784	Response regulator, receiver
EZ55_00337	COG1609	Transcriptional regulator
EZ55_00338	COG0673	inositol 2-dehydrogenase activity
EZ55_00340	COG2211	Major facilitator Superfamily
EZ55_00345	COG1454	alcohol dehydrogenase
EZ55_00351	COG3344	reverse transcriptase
EZ55_00357	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ55_00361	COG0089	rRNA binding
EZ55_00363	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZ55_00365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZ55_00368	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZ55_00370	COG1519	Transferase
EZ55_00378	COG0788	formyltetrahydrofolate deformylase activity
EZ55_00380	COG1643	Atp-dependent helicase
EZ55_00382	COG2951	lytic endotransglycosylase activity
EZ55_00383	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZ55_00386	COG2354	Protein conserved in bacteria
EZ55_00391	COG0004	ammonium transporteR
EZ55_00394	COG3344	reverse transcriptase
EZ55_00395	COG0405	Gamma-glutamyltransferase
EZ55_00396	COG2837	iron assimilation
EZ55_00399	COG0540	Belongs to the ATCase OTCase family
EZ55_00404	COG4999	Histidine kinase
EZ55_00404	COG3850	Histidine kinase
EZ55_00404	COG3437	response regulator, receiver
EZ55_00404	COG2205	protein histidine kinase activity
EZ55_00407	COG5001	Diguanylate cyclase
EZ55_00407	COG3300	MHYT domain
EZ55_00409	COG1012	belongs to the aldehyde dehydrogenase family
EZ55_00411	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZ55_00413	COG0512	Glutamine amidotransferase of anthranilate synthase
EZ55_00414	COG0180	Tryptophanyl-tRNA synthetase
EZ55_00415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EZ55_00419	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EZ55_00421	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZ55_00428	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZ55_00429	COG0281	malic enzyme
EZ55_00431	COG0625	glutathione transferase activity
EZ55_00433	COG0753	catalase activity
EZ55_00438	COG5001	Diguanylate cyclase
EZ55_00438	COG3300	MHYT domain
EZ55_00439	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZ55_00439	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EZ55_00441	COG0137	argininosuccinate synthase activity
EZ55_00445	COG1803	Methylglyoxal synthase
EZ55_00447	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EZ55_00450	COG0745	RESPONSE REGULATOR receiver
EZ55_00451	COG2205	protein histidine kinase activity
EZ55_00452	COG2267	carboxylic ester hydrolase activity
EZ55_00453	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EZ55_00454	COG2205	protein histidine kinase activity
EZ55_00455	COG0745	RESPONSE REGULATOR receiver
EZ55_00459	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_00460	COG0577	efflux transmembrane transporter activity
EZ55_00460	COG1136	(ABC) transporter
EZ55_00463	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZ55_00465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZ55_00466	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZ55_00467	COG4942	peptidase
EZ55_00468	COG2861	carbohydrate metabolic process
EZ55_00470	COG0584	glycerophosphoryl diester phosphodiesterase
EZ55_00473	COG1162	GTPase activity
EZ55_00474	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EZ55_00481	COG3344	reverse transcriptase
EZ55_00483	COG3385	transposase activity
EZ55_00485	COG0028	Belongs to the TPP enzyme family
EZ55_00489	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZ55_00490	COG0805	protein transport
EZ55_00492	COG0084	hydrolase, TatD family'
EZ55_00493	COG5001	Diguanylate cyclase
EZ55_00493	COG4251	negative regulation of phosphorylation
EZ55_00493	COG3706	GGDEF domain
EZ55_00493	COG2203	Gaf domain
EZ55_00495	COG0248	Ppx GppA phosphatase
EZ55_00496	COG0513	Belongs to the DEAD box helicase family
EZ55_00497	COG3118	belongs to the thioredoxin family
EZ55_00498	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EZ55_00499	COG1473	amidohydrolase
EZ55_00500	COG2205	protein histidine kinase activity
EZ55_00500	COG0784	Response regulator, receiver
EZ55_00501	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZ55_00502	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EZ55_00503	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EZ55_00506	COG0783	Belongs to the Dps family
EZ55_00507	COG2133	pyrroloquinoline quinone binding
EZ55_00508	COG1506	peptidase
EZ55_00508	COG0823	Involved in the tonB-independent uptake of proteins
EZ55_00508	COG4946	Tricorn protease homolog
EZ55_00510	COG3118	belongs to the thioredoxin family
EZ55_00513	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EZ55_00515	COG1012	belongs to the aldehyde dehydrogenase family
EZ55_00519	COG1757	Na H antiporter
EZ55_00522	COG3876	Protein conserved in bacteria
EZ55_00523	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EZ55_00527	COG0346	lactoylglutathione lyase activity
EZ55_00533	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZ55_00535	COG2824	Alkylphosphonate utilization operon protein PhnA
EZ55_00536	COG0454	-acetyltransferase
EZ55_00538	COG1742	UPF0060 membrane protein
EZ55_00545	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_00548	COG4115	mRNA cleavage
EZ55_00549	COG2161	toxin-antitoxin pair type II binding
EZ55_00557	COG3344	reverse transcriptase
EZ55_00561	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_00568	COG2226	methyltransferase
EZ55_00583	COG2226	methyltransferase
EZ55_00585	COG0183	Belongs to the thiolase family
EZ55_00586	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ55_00586	COG1024	Enoyl-CoA hydratase
EZ55_00587	COG0739	heme binding
EZ55_00587	COG1196	nuclear chromosome segregation
EZ55_00587	COG0741	lytic transglycosylase activity
EZ55_00588	COG0006	proline dipeptidase activity
EZ55_00590	COG0142	geranyltranstransferase activity
EZ55_00600	COG1388	LysM domain
EZ55_00600	COG4942	peptidase
EZ55_00601	COG1238	metal cluster binding
EZ55_00603	COG0585	pseudouridine synthase activity
EZ55_00604	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZ55_00606	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EZ55_00608	COG0840	transmembrane signaling receptor activity
EZ55_00609	COG0506	proline dehydrogenase activity
EZ55_00609	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EZ55_00609	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EZ55_00612	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_00619	COG0494	nUDIX hydrolase
EZ55_00620	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EZ55_00621	COG0730	response to heat
EZ55_00622	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EZ55_00623	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EZ55_00625	COG3706	GGDEF domain
EZ55_00626	COG4999	Histidine kinase
EZ55_00626	COG3437	response regulator, receiver
EZ55_00626	COG3850	Histidine kinase
EZ55_00626	COG2205	protein histidine kinase activity
EZ55_00627	COG2211	Major facilitator Superfamily
EZ55_00631	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZ55_00634	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EZ55_00635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ55_00639	COG1648	precorrin-2 dehydrogenase activity
EZ55_00639	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZ55_00640	COG0513	Belongs to the DEAD box helicase family
EZ55_00644	COG1538	Outer membrane efflux protein
EZ55_00645	COG0494	nUDIX hydrolase
EZ55_00647	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EZ55_00648	COG3150	esterase
EZ55_00650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EZ55_00653	COG0443	Heat shock 70 kDa protein
EZ55_00654	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZ55_00657	COG5433	transposase activity
EZ55_00659	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ55_00663	COG1509	lysine 2,3-aminomutase activity
EZ55_00664	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZ55_00669	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZ55_00673	COG0271	Belongs to the BolA IbaG family
EZ55_00676	COG3707	response regulator
EZ55_00678	COG0659	secondary active sulfate transmembrane transporter activity
EZ55_00679	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZ55_00680	COG2146	nitrite reductase [NAD(P)H] activity
EZ55_00681	COG0243	molybdopterin cofactor binding
EZ55_00682	COG1648	precorrin-2 dehydrogenase activity
EZ55_00682	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZ55_00683	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZ55_00684	COG0737	Belongs to the 5'-nucleotidase family
EZ55_00685	COG2203	Gaf domain
EZ55_00685	COG5001	Diguanylate cyclase
EZ55_00685	COG3706	GGDEF domain
EZ55_00685	COG4251	negative regulation of phosphorylation
EZ55_00688	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZ55_00688	COG1116	anion transmembrane transporter activity
EZ55_00690	COG1116	anion transmembrane transporter activity
EZ55_00693	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZ55_00694	COG4206	TonB-dependent receptor
EZ55_00696	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EZ55_00697	COG0348	domain, Protein
EZ55_00700	COG1960	acyl-CoA dehydrogenase activity
EZ55_00703	COG4948	Mandelate Racemase Muconate Lactonizing
EZ55_00707	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_00708	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_00712	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZ55_00713	COG0358	DNA primase activity
EZ55_00718	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EZ55_00719	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZ55_00722	COG0537	adenosine 5'-monophosphoramidase activity
EZ55_00725	COG3135	benzoate transporter
EZ55_00726	COG1396	sequence-specific DNA binding
EZ55_00727	COG2974	May be involved in recombination
EZ55_00728	COG4191	Histidine kinase
EZ55_00728	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ55_00729	COG0745	RESPONSE REGULATOR receiver
EZ55_00730	COG5002	protein histidine kinase activity
EZ55_00736	COG0811	peptide transport
EZ55_00737	COG0811	peptide transport
EZ55_00738	COG0848	biopolymer transport protein
EZ55_00739	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EZ55_00741	COG3437	response regulator, receiver
EZ55_00745	COG2133	pyrroloquinoline quinone binding
EZ55_00746	COG1049	propionate catabolic process, 2-methylcitrate cycle
EZ55_00754	COG0527	aspartate kinase activity
EZ55_00756	COG0840	transmembrane signaling receptor activity
EZ55_00757	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EZ55_00758	COG2967	ApaG domain
EZ55_00760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EZ55_00761	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ55_00762	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EZ55_00763	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EZ55_00765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZ55_00769	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EZ55_00772	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZ55_00773	COG3956	TIGRFAM MazG family protein
EZ55_00777	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_00779	COG0318	PFAM AMP-dependent synthetase and ligase
EZ55_00781	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EZ55_00783	COG0463	Glycosyl transferase, family 2
EZ55_00787	COG0642	Histidine kinase
EZ55_00791	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZ55_00792	COG0723	plastoquinol--plastocyanin reductase activity
EZ55_00793	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZ55_00794	COG2857	Cytochrome c1
EZ55_00795	COG0625	glutathione transferase activity
EZ55_00796	COG2969	positive regulation of protein catabolic process
EZ55_00799	COG0745	RESPONSE REGULATOR receiver
EZ55_00800	COG2239	Acts as a magnesium transporter
EZ55_00801	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ55_00805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EZ55_00806	COG1137	ATPase activity
EZ55_00807	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EZ55_00809	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EZ55_00812	COG1127	ABC transporter
EZ55_00813	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZ55_00814	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EZ55_00815	COG2854	intermembrane phospholipid transfer
EZ55_00817	COG5007	Belongs to the BolA IbaG family
EZ55_00819	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZ55_00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZ55_00822	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EZ55_00828	COG2308	Evidence 4 Homologs of previously reported genes of
EZ55_00829	COG1305	Transglutaminase-like
EZ55_00833	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZ55_00837	COG4771	TonB-dependent receptor
EZ55_00838	COG0697	spore germination
EZ55_00840	COG0784	Response regulator, receiver
EZ55_00840	COG2205	protein histidine kinase activity
EZ55_00845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZ55_00847	COG0126	phosphoglycerate kinase activity
EZ55_00848	COG3588	fructose-bisphosphate aldolase
EZ55_00852	COG1538	Outer membrane efflux protein
EZ55_00854	COG0823	Involved in the tonB-independent uptake of proteins
EZ55_00854	COG1506	peptidase
EZ55_00854	COG4946	Tricorn protease homolog
EZ55_00855	COG0248	Ppx GppA phosphatase
EZ55_00856	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZ55_00858	COG0573	inorganic phosphate transmembrane transporter activity
EZ55_00860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZ55_00862	COG0306	phosphate transporter
EZ55_00864	COG0583	DNA-binding transcription factor activity
EZ55_00869	COG1272	protein, Hemolysin III
EZ55_00871	COG1846	Transcriptional regulator
EZ55_00872	COG1764	response to oxidative stress
EZ55_00876	COG3344	reverse transcriptase
EZ55_00878	COG1739	Uncharacterized protein family UPF0029
EZ55_00882	COG0583	DNA-binding transcription factor activity
EZ55_00883	COG4989	oxidoreductase activity
EZ55_00889	COG0420	3'-5' exonuclease activity
EZ55_00890	COG0419	ATPase involved in DNA repair
EZ55_00892	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EZ55_00896	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EZ55_00897	COG2986	histidine ammonia-lyase
EZ55_00901	COG2971	BadF BadG BcrA BcrD
EZ55_00902	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZ55_00904	COG0488	(ABC) transporter
EZ55_00910	COG0668	transmembrane transport
EZ55_00915	COG2814	Major facilitator Superfamily
EZ55_00938	COG1346	cytolysis
EZ55_00944	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZ55_00945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZ55_00946	COG0513	Belongs to the DEAD box helicase family
EZ55_00950	COG3409	Peptidoglycan-binding domain 1 protein
EZ55_00950	COG3267	Type II secretory pathway component ExeA
EZ55_00955	COG0473	3-isopropylmalate dehydrogenase activity
EZ55_00956	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZ55_00960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EZ55_00963	COG4555	ABC transporter
EZ55_00964	COG1668	transmembrane transport
EZ55_00967	COG4133	protoheme IX ABC transporter activity
EZ55_00968	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZ55_00969	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZ55_00970	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZ55_00972	COG1138	Cytochrome C-type biogenesis protein
EZ55_00976	COG2853	Lipoprotein
EZ55_00977	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZ55_00985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZ55_00988	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZ55_00989	COG1596	polysaccharide export
EZ55_00989	COG1555	photosystem II stabilization
EZ55_00990	COG0473	3-isopropylmalate dehydrogenase activity
EZ55_00993	COG1611	Belongs to the LOG family
EZ55_01001	COG0071	Belongs to the small heat shock protein (HSP20) family
EZ55_01002	COG2801	Transposase and inactivated derivatives
EZ55_01006	COG0564	pseudouridine synthase activity
EZ55_01009	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZ55_01010	COG0024	Methionine aminopeptidase
EZ55_01012	COG0052	Belongs to the universal ribosomal protein uS2 family
EZ55_01014	COG0528	UMP kinase activity
EZ55_01016	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZ55_01017	COG0575	Belongs to the CDS family
EZ55_01022	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZ55_01023	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ55_01026	COG0587	DNA-directed DNA polymerase activity
EZ55_01027	COG0825	malonyl-CoA metabolic process
EZ55_01028	COG0037	tRNA processing
EZ55_01035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZ55_01035	COG0047	phosphoribosylformylglycinamidine synthase activity
EZ55_01037	COG2840	Smr protein MutS2
EZ55_01045	COG0784	Response regulator, receiver
EZ55_01045	COG0835	chemotaxis
EZ55_01046	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZ55_01047	COG1815	bacterial-type flagellum-dependent cell motility
EZ55_01050	COG1749	Flagellar hook protein flgE
EZ55_01051	COG4787	bacterial-type flagellum-dependent cell motility
EZ55_01055	COG1705	Flagellar rod assembly protein muramidase FlgJ
EZ55_01055	COG3951	Flagellar rod assembly protein muramidase FlgJ
EZ55_01056	COG1256	bacterial-type flagellum assembly
EZ55_01060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZ55_01061	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZ55_01073	COG1677	Flagellar hook-basal body complex protein FliE
EZ55_01074	COG1766	The M ring may be actively involved in energy transduction
EZ55_01075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EZ55_01085	COG1987	bacterial-type flagellum assembly
EZ55_01089	COG2989	Protein conserved in bacteria
EZ55_01090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EZ55_01095	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EZ55_01096	COG0643	Histidine kinase
EZ55_01096	COG0784	Response regulator, receiver
EZ55_01096	COG2198	Histidine kinase
EZ55_01097	COG2201	protein-glutamate methylesterase activity
EZ55_01098	COG1192	Involved in chromosome partitioning
EZ55_01100	COG0835	chemotaxis
EZ55_01103	COG0646	methionine synthase
EZ55_01103	COG1410	methionine synthase
EZ55_01104	COG0646	methionine synthase
EZ55_01104	COG1410	methionine synthase
EZ55_01106	COG3123	guanosine phosphorylase activity
EZ55_01108	COG0583	DNA-binding transcription factor activity
EZ55_01109	COG0583	DNA-binding transcription factor activity
EZ55_01110	COG0288	reversible hydration of carbon dioxide
EZ55_01111	COG0659	secondary active sulfate transmembrane transporter activity
EZ55_01113	COG1309	transcriptional regulator
EZ55_01114	COG3590	peptidase
EZ55_01116	COG2137	regulation of response to DNA damage stimulus
EZ55_01117	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZ55_01123	COG1607	acyl-coa hydrolase
EZ55_01125	COG0511	ligase activity, forming carbon-carbon bonds
EZ55_01125	COG5016	pyruvate
EZ55_01126	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EZ55_01127	COG4172	Belongs to the ABC transporter superfamily
EZ55_01129	COG4171	peptide transport system, permease
EZ55_01130	COG4168	peptide transport system, permease
EZ55_01131	COG0747	negative chemotaxis
EZ55_01132	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EZ55_01133	COG1842	Phage shock protein A
EZ55_01139	COG0625	glutathione transferase activity
EZ55_01140	COG1522	sequence-specific DNA binding
EZ55_01153	COG0811	peptide transport
EZ55_01154	COG0811	peptide transport
EZ55_01155	COG0848	biopolymer transport protein
EZ55_01158	COG1444	tRNA N-acetyltransferase activity
EZ55_01167	COG0456	acetyltransferase
EZ55_01170	COG0583	DNA-binding transcription factor activity
EZ55_01171	COG2814	Major facilitator Superfamily
EZ55_01174	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_01177	COG1846	Transcriptional regulator
EZ55_01179	COG3275	phosphorelay sensor kinase activity
EZ55_01180	COG1966	Carbon starvation protein
EZ55_01184	COG0457	Tetratricopeptide repeat
EZ55_01187	COG2197	response regulator
EZ55_01189	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZ55_01195	COG0583	DNA-binding transcription factor activity
EZ55_01196	COG0702	epimerase
EZ55_01200	COG1902	pentaerythritol trinitrate reductase activity
EZ55_01203	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EZ55_01204	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZ55_01206	COG0564	pseudouridine synthase activity
EZ55_01208	COG0612	Peptidase, M16
EZ55_01209	COG2918	glutathione biosynthetic process
EZ55_01214	COG2840	Smr protein MutS2
EZ55_01215	COG2890	protein-(glutamine-N5) methyltransferase activity
EZ55_01218	COG2719	SpoVR family
EZ55_01219	COG2718	Belongs to the UPF0229 family
EZ55_01220	COG2766	serine protein kinase
EZ55_01223	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZ55_01224	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZ55_01225	COG4771	TonB-dependent receptor
EZ55_01230	COG0450	alkyl hydroperoxide reductase
EZ55_01231	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZ55_01232	COG2885	chlorophyll binding
EZ55_01233	COG0584	glycerophosphoryl diester phosphodiesterase
EZ55_01234	COG0346	lactoylglutathione lyase activity
EZ55_01235	COG4221	oxidoreductase activity
EZ55_01237	COG1278	Cold shock
EZ55_01240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZ55_01241	COG4660	Part of a membrane complex involved in electron transport
EZ55_01242	COG4659	FMN binding
EZ55_01243	COG4658	electron transport chain
EZ55_01244	COG4656	Part of a membrane complex involved in electron transport
EZ55_01245	COG2878	Part of a membrane complex involved in electron transport
EZ55_01246	COG4657	Part of a membrane complex involved in electron transport
EZ55_01249	COG0534	Mate efflux family protein
EZ55_01250	COG0556	nucleotide-excision repair
EZ55_01253	COG0602	queuosine metabolic process
EZ55_01255	COG3385	transposase activity
EZ55_01256	COG0367	asparagine synthase
EZ55_01261	COG0471	metal ion transport
EZ55_01261	COG3273	potassium ion transport
EZ55_01264	COG0529	Catalyzes the synthesis of activated sulfate
EZ55_01265	COG0175	sulfate reduction
EZ55_01266	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZ55_01272	COG2304	oxidoreductase activity
EZ55_01276	COG0714	Associated with various cellular activities
EZ55_01279	COG1024	Enoyl-CoA hydratase
EZ55_01279	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ55_01282	COG3344	reverse transcriptase
EZ55_01286	COG1025	Belongs to the peptidase M16 family
EZ55_01287	COG2062	phosphohistidine phosphatase, SixA
EZ55_01289	COG4536	flavin adenine dinucleotide binding
EZ55_01290	COG4137	Cytochrome C assembly protein
EZ55_01291	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EZ55_01299	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_01300	COG1132	(ABC) transporter
EZ55_01303	COG0228	four-way junction DNA binding
EZ55_01304	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZ55_01305	COG0336	Belongs to the RNA methyltransferase TrmD family
EZ55_01306	COG0335	large ribosomal subunit rRNA binding
EZ55_01307	COG3344	reverse transcriptase
EZ55_01308	COG2860	membrane
EZ55_01310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZ55_01311	COG0287	Prephenate dehydrogenase
EZ55_01311	COG1605	Chorismate mutase
EZ55_01317	COG1605	Chorismate mutase
EZ55_01317	COG0077	Prephenate dehydratase
EZ55_01318	COG0745	RESPONSE REGULATOR receiver
EZ55_01319	COG0023	Translation Initiation Factor
EZ55_01321	COG0745	RESPONSE REGULATOR receiver
EZ55_01325	COG2205	protein histidine kinase activity
EZ55_01327	COG2204	response regulator
EZ55_01330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EZ55_01331	COG0494	nUDIX hydrolase
EZ55_01332	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZ55_01333	COG0632	four-way junction helicase activity
EZ55_01334	COG2255	four-way junction helicase activity
EZ55_01335	COG0824	Thioesterase
EZ55_01336	COG0811	peptide transport
EZ55_01339	COG0823	Involved in the tonB-independent uptake of proteins
EZ55_01340	COG2885	chlorophyll binding
EZ55_01341	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EZ55_01345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EZ55_01353	COG4667	esterase of the alpha-beta hydrolase superfamily
EZ55_01354	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZ55_01356	COG0784	Response regulator, receiver
EZ55_01356	COG2205	protein histidine kinase activity
EZ55_01359	COG3038	cytochrome b561
EZ55_01363	COG1451	nucleotide metabolic process
EZ55_01365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_01367	COG1309	transcriptional regulator
EZ55_01368	COG4774	siderophore transport
EZ55_01372	COG3706	GGDEF domain
EZ55_01374	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EZ55_01374	COG3008	intermembrane lipid transfer
EZ55_01375	COG2995	paraquat-inducible protein a
EZ55_01378	COG3436	PFAM IS66 Orf2 family protein
EZ55_01379	COG4372	Transposase
EZ55_01383	COG4206	TonB-dependent receptor
EZ55_01389	COG2871	sodium ion transport
EZ55_01392	COG0017	Asparaginyl-tRNA synthetase
EZ55_01395	COG0189	ligase activity
EZ55_01402	COG2226	methyltransferase
EZ55_01405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZ55_01406	COG4139	cobalamin transport
EZ55_01408	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EZ55_01409	COG2205	protein histidine kinase activity
EZ55_01410	COG0745	RESPONSE REGULATOR receiver
EZ55_01411	COG0569	domain protein
EZ55_01412	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZ55_01415	COG5265	(ABC) transporter
EZ55_01416	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZ55_01418	COG0745	RESPONSE REGULATOR receiver
EZ55_01423	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZ55_01432	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ55_01435	COG2755	lipolytic protein G-D-S-L family
EZ55_01436	COG4181	ATPase activity
EZ55_01437	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EZ55_01438	COG1090	epimerase
EZ55_01439	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZ55_01440	COG0628	permease
EZ55_01445	COG2350	Protein conserved in bacteria
EZ55_01446	COG0159	tryptophan synthase activity
EZ55_01448	COG0135	phosphoribosylanthranilate isomerase activity
EZ55_01448	COG0134	indole-3-glycerol-phosphate synthase activity
EZ55_01449	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZ55_01451	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZ55_01452	COG0613	PHP domain protein
EZ55_01453	COG0009	L-threonylcarbamoyladenylate synthase
EZ55_01455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZ55_01457	COG0656	L-ascorbic acid biosynthetic process
EZ55_01458	COG0110	maltose O-acetyltransferase activity
EZ55_01461	COG2733	membrane
EZ55_01462	COG0500	methyltransferase
EZ55_01463	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ55_01464	COG0497	DNA recombination
EZ55_01465	COG0783	Belongs to the Dps family
EZ55_01466	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EZ55_01468	COG1454	alcohol dehydrogenase
EZ55_01469	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_01471	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZ55_01472	COG2610	gluconate transmembrane transporter activity
EZ55_01473	COG4771	TonB-dependent receptor
EZ55_01476	COG2205	protein histidine kinase activity
EZ55_01476	COG2198	Histidine kinase
EZ55_01476	COG0784	Response regulator, receiver
EZ55_01478	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EZ55_01480	COG0484	heat shock protein binding
EZ55_01481	COG3909	cytochrome
EZ55_01484	COG2199	diguanylate cyclase activity
EZ55_01484	COG2200	EAL domain
EZ55_01484	COG2202	Pas domain
EZ55_01487	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EZ55_01489	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZ55_01490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZ55_01495	COG0071	Belongs to the small heat shock protein (HSP20) family
EZ55_01497	COG0280	phosphate acetyltransferase
EZ55_01497	COG0857	belongs to the CobB CobQ family
EZ55_01498	COG1228	amidohydrolase
EZ55_01499	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EZ55_01500	COG4535	Mg2 and Co2 transporter CorC
EZ55_01502	COG1702	phosphate starvation-inducible protein PhoH
EZ55_01504	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ55_01514	COG1607	acyl-coa hydrolase
EZ55_01515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZ55_01517	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_01519	COG1115	amino acid carrier protein
EZ55_01529	COG0012	GTP binding
EZ55_01532	COG1064	alcohol dehydrogenase
EZ55_01534	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZ55_01536	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EZ55_01537	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EZ55_01538	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EZ55_01540	COG2890	protein-(glutamine-N5) methyltransferase activity
EZ55_01541	COG3437	response regulator, receiver
EZ55_01541	COG0784	Response regulator, receiver
EZ55_01543	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EZ55_01545	COG0583	DNA-binding transcription factor activity
EZ55_01547	COG2363	Small membrane protein
EZ55_01550	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EZ55_01551	COG0515	serine threonine protein kinase
EZ55_01552	COG2116	formate transmembrane transporter activity
EZ55_01555	COG0714	Associated with various cellular activities
EZ55_01557	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EZ55_01558	COG0033	Phosphoglucomutase
EZ55_01559	COG0058	SHG alpha-glucan phosphorylase activity
EZ55_01562	COG2988	succinylglutamate desuccinylase activity
EZ55_01565	COG1301	dicarboxylic acid transport
EZ55_01569	COG1393	Belongs to the ArsC family
EZ55_01575	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EZ55_01579	COG5001	Diguanylate cyclase
EZ55_01579	COG3300	MHYT domain
EZ55_01582	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_01585	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZ55_01590	COG1733	regulation of RNA biosynthetic process
EZ55_01592	COG3447	MASE1 domain protein
EZ55_01592	COG5001	Diguanylate cyclase
EZ55_01592	COG5002	protein histidine kinase activity
EZ55_01594	COG0402	S-adenosylhomocysteine deaminase activity
EZ55_01598	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZ55_01600	COG1309	transcriptional regulator
EZ55_01602	COG2252	PERMEase
EZ55_01603	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZ55_01607	COG2205	protein histidine kinase activity
EZ55_01607	COG0784	Response regulator, receiver
EZ55_01610	COG2233	PERMEase
EZ55_01611	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZ55_01614	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EZ55_01615	COG0730	response to heat
EZ55_01617	COG0154	amidase activity
EZ55_01624	COG3001	Fructosamine kinase
EZ55_01626	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EZ55_01630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZ55_01633	COG1596	polysaccharide export
EZ55_01634	COG0489	protein tyrosine kinase activity
EZ55_01635	COG4464	protein tyrosine phosphatase activity
EZ55_01642	COG0438	transferase activity, transferring glycosyl groups
EZ55_01651	COG2327	Polysaccharide pyruvyl transferase
EZ55_01656	COG2755	lipolytic protein G-D-S-L family
EZ55_01656	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZ55_01657	COG1045	serine acetyltransferase
EZ55_01662	COG0072	phenylalanine-tRNA ligase activity
EZ55_01662	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ55_01668	COG1472	Belongs to the glycosyl hydrolase 3 family
EZ55_01669	COG2096	Adenosyltransferase
EZ55_01671	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZ55_01673	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZ55_01677	COG0708	Exodeoxyribonuclease III
EZ55_01684	COG2814	Major facilitator Superfamily
EZ55_01691	COG4770	biotin carboxylase activity
EZ55_01692	COG1024	Enoyl-CoA hydratase
EZ55_01693	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZ55_01694	COG1960	acyl-CoA dehydrogenase activity
EZ55_01695	COG0789	Transcriptional regulator
EZ55_01696	COG0183	Belongs to the thiolase family
EZ55_01701	COG2925	Exonuclease
EZ55_01702	COG5002	protein histidine kinase activity
EZ55_01702	COG2205	protein histidine kinase activity
EZ55_01702	COG0784	Response regulator, receiver
EZ55_01710	COG1643	Atp-dependent helicase
EZ55_01714	COG3321	synthase
EZ55_01714	COG0604	alcohol dehydrogenase
EZ55_01715	COG0328	RNA-DNA hybrid ribonuclease activity
EZ55_01716	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZ55_01722	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EZ55_01723	COG1136	(ABC) transporter
EZ55_01724	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZ55_01726	COG1301	dicarboxylic acid transport
EZ55_01728	COG3724	N-succinylarginine dihydrolase activity
EZ55_01729	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZ55_01730	COG3122	Protein conserved in bacteria
EZ55_01732	COG0583	DNA-binding transcription factor activity
EZ55_01733	COG0746	molybdenum cofactor guanylyltransferase activity
EZ55_01734	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZ55_01735	COG0243	molybdopterin cofactor binding
EZ55_01737	COG0625	glutathione transferase activity
EZ55_01740	COG2153	protein acetylation
EZ55_01743	COG5002	protein histidine kinase activity
EZ55_01745	COG1530	ribonuclease E activity
EZ55_01747	COG0564	pseudouridine synthase activity
EZ55_01749	COG0424	maF-like protein
EZ55_01750	COG1399	metal-binding, possibly nucleic acid-binding protein
EZ55_01752	COG0416	fatty acid biosynthetic process
EZ55_01753	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZ55_01754	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EZ55_01756	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZ55_01757	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZ55_01758	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZ55_01759	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZ55_01762	COG0084	hydrolase, TatD family'
EZ55_01763	COG0259	pyridoxamine-phosphate oxidase activity
EZ55_01764	COG0702	epimerase
EZ55_01765	COG3706	GGDEF domain
EZ55_01770	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_01771	COG0596	Alpha beta hydrolase
EZ55_01772	COG1024	Enoyl-CoA hydratase
EZ55_01772	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ55_01773	COG0183	Belongs to the thiolase family
EZ55_01774	COG1960	acyl-CoA dehydrogenase activity
EZ55_01775	COG0596	Alpha beta hydrolase
EZ55_01778	COG2390	Transcriptional regulator
EZ55_01779	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ55_01781	COG0246	Mannitol dehydrogenase
EZ55_01784	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZ55_01785	COG0523	cobalamin synthesis protein
EZ55_01786	COG0277	FAD linked oxidase domain protein
EZ55_01786	COG0247	lactate metabolic process
EZ55_01791	COG0668	transmembrane transport
EZ55_01792	COG4771	TonB-dependent receptor
EZ55_01797	COG0784	Response regulator, receiver
EZ55_01797	COG2198	Histidine kinase
EZ55_01797	COG2205	protein histidine kinase activity
EZ55_01798	COG3437	response regulator, receiver
EZ55_01800	COG0195	Participates in both transcription termination and antitermination
EZ55_01803	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EZ55_01806	COG3300	MHYT domain
EZ55_01806	COG5001	Diguanylate cyclase
EZ55_01807	COG1187	pseudouridine synthase activity
EZ55_01809	COG3153	acetyltransferase
EZ55_01809	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ55_01823	COG1032	radical SAM domain protein
EZ55_01826	COG4771	TonB-dependent receptor
EZ55_01827	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ55_01829	COG4134	Bacterial extracellular solute-binding protein
EZ55_01831	COG4136	ATPase activity
EZ55_01832	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZ55_01835	COG0604	alcohol dehydrogenase
EZ55_01842	COG0583	DNA-binding transcription factor activity
EZ55_01843	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZ55_01846	COG0583	DNA-binding transcription factor activity
EZ55_01851	COG1131	(ABC) transporter
EZ55_01853	COG1902	pentaerythritol trinitrate reductase activity
EZ55_01855	COG2867	negative regulation of translational initiation
EZ55_01856	COG2914	Belongs to the UPF0125 (RnfH) family
EZ55_01858	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ55_01859	COG4771	TonB-dependent receptor
EZ55_01860	COG0457	Tetratricopeptide repeat
EZ55_01864	COG0574	Belongs to the PEP-utilizing enzyme family
EZ55_01864	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZ55_01872	COG2850	peptidyl-arginine hydroxylation
EZ55_01874	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZ55_01875	COG2915	High frequency lysogenization protein hflD homolog
EZ55_01876	COG0482	sulfurtransferase activity
EZ55_01877	COG1187	pseudouridine synthase activity
EZ55_01880	COG1278	Cold shock
EZ55_01881	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZ55_01882	COG0542	response to heat
EZ55_01883	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EZ55_01884	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EZ55_01885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EZ55_01886	COG0492	ferredoxin-NADP+ reductase activity
EZ55_01887	COG3092	negative regulation of chromosome organization
EZ55_01888	COG0616	signal peptide processing
EZ55_01891	COG0778	Nitroreductase
EZ55_01893	COG0252	asparaginase activity
EZ55_01894	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZ55_01895	COG0321	lipoyl(octanoyl) transferase activity
EZ55_01896	COG2921	Belongs to the UPF0250 family
EZ55_01897	COG1686	Belongs to the peptidase S11 family
EZ55_01898	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZ55_01899	COG0772	Belongs to the SEDS family
EZ55_01900	COG0768	penicillin binding
EZ55_01901	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EZ55_01902	COG0799	negative regulation of ribosome biogenesis
EZ55_01904	COG1466	dna polymerase III delta subunit
EZ55_01905	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EZ55_01906	COG0495	leucyl-tRNA aminoacylation
EZ55_01908	COG1067	ATP-dependent peptidase activity
EZ55_01912	COG1534	Rna-binding protein
EZ55_01913	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EZ55_01914	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZ55_01915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZ55_01916	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZ55_01917	COG0149	triose-phosphate isomerase activity
EZ55_01918	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZ55_01924	COG1597	lipid kinase activity
EZ55_01924	COG1803	Methylglyoxal synthase
EZ55_01926	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_01927	COG0561	phosphatase activity
EZ55_01930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZ55_01931	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZ55_01932	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZ55_01935	COG1185	polyribonucleotide nucleotidyltransferase activity
EZ55_01943	COG3436	PFAM IS66 Orf2 family protein
EZ55_01945	COG3328	transposase activity
EZ55_01966	COG2223	nitrite transmembrane transporter activity
EZ55_01975	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EZ55_01976	COG1196	nuclear chromosome segregation
EZ55_01978	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EZ55_01981	COG1132	(ABC) transporter
EZ55_01982	COG1663	tetraacyldisaccharide 4'-kinase activity
EZ55_01990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EZ55_01991	COG0435	Glutathione S-transferase
EZ55_01992	COG1741	Belongs to the pirin family
EZ55_01997	COG0372	Belongs to the citrate synthase family
EZ55_01999	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EZ55_02000	COG1053	succinate dehydrogenase
EZ55_02001	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EZ55_02002	COG0567	Dehydrogenase, E1 component
EZ55_02003	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZ55_02010	COG4667	esterase of the alpha-beta hydrolase superfamily
EZ55_02014	COG0366	Alpha amylase catalytic
EZ55_02016	COG0366	Alpha amylase catalytic
EZ55_02016	COG1874	Beta-galactosidase
EZ55_02017	COG1609	Transcriptional regulator
EZ55_02019	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02020	COG2267	carboxylic ester hydrolase activity
EZ55_02022	COG0616	signal peptide processing
EZ55_02025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EZ55_02026	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZ55_02027	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZ55_02028	COG0386	Belongs to the glutathione peroxidase family
EZ55_02029	COG2084	Dehydrogenase
EZ55_02031	COG1960	acyl-CoA dehydrogenase activity
EZ55_02032	COG1024	Enoyl-CoA hydratase
EZ55_02033	COG2226	methyltransferase
EZ55_02034	COG3083	sulfuric ester hydrolase activity
EZ55_02035	COG3082	Protein of unknown function (DUF1414)
EZ55_02036	COG3081	Nucleoid-associated protein
EZ55_02038	COG0739	heme binding
EZ55_02038	COG0741	lytic transglycosylase activity
EZ55_02038	COG1196	nuclear chromosome segregation
EZ55_02042	COG3275	phosphorelay sensor kinase activity
EZ55_02043	COG3279	Response regulator of the LytR AlgR family
EZ55_02044	COG0205	6-phosphofructokinase activity
EZ55_02047	COG3328	transposase activity
EZ55_02049	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ55_02049	COG2205	protein histidine kinase activity
EZ55_02051	COG1054	Belongs to the UPF0176 family
EZ55_02053	COG2826	transposase and inactivated derivatives, IS30 family
EZ55_02056	COG0604	alcohol dehydrogenase
EZ55_02056	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZ55_02056	COG3321	synthase
EZ55_02056	COG4221	oxidoreductase activity
EZ55_02057	COG4221	oxidoreductase activity
EZ55_02058	COG0583	DNA-binding transcription factor activity
EZ55_02061	COG0513	Belongs to the DEAD box helicase family
EZ55_02063	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EZ55_02064	COG0583	DNA-binding transcription factor activity
EZ55_02068	COG1760	l-serine dehydratase
EZ55_02072	COG1322	Protein conserved in bacteria
EZ55_02073	COG1404	Belongs to the peptidase S8 family
EZ55_02074	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZ55_02075	COG0022	dehydrogenase e1 component
EZ55_02077	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EZ55_02078	COG0515	serine threonine protein kinase
EZ55_02079	COG1946	Acyl-CoA thioesterase
EZ55_02082	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EZ55_02084	COG1956	GAF domain-containing protein
EZ55_02087	COG0793	Belongs to the peptidase S41A family
EZ55_02088	COG0733	neurotransmitter:sodium symporter activity
EZ55_02089	COG1757	Na H antiporter
EZ55_02090	COG0308	aminopeptidase N
EZ55_02096	COG2902	Dehydrogenase
EZ55_02097	COG0167	dihydroorotate dehydrogenase activity
EZ55_02100	COG0488	(ABC) transporter
EZ55_02102	COG3130	regulation of translation
EZ55_02103	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZ55_02105	COG0415	Belongs to the DNA photolyase family
EZ55_02106	COG0415	Belongs to the DNA photolyase family
EZ55_02107	COG0415	Belongs to the DNA photolyase family
EZ55_02108	COG3046	protein related to deoxyribodipyrimidine photolyase
EZ55_02120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ55_02123	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EZ55_02124	COG0589	response to stress
EZ55_02126	COG0069	glutamate synthase activity
EZ55_02129	COG2193	ferroxidase activity
EZ55_02131	COG3278	Belongs to the heme-copper respiratory oxidase family
EZ55_02134	COG2010	Cytochrome c
EZ55_02139	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ55_02140	COG3385	transposase activity
EZ55_02141	COG0589	response to stress
EZ55_02142	COG0037	tRNA processing
EZ55_02143	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZ55_02147	COG1280	lysine exporter protein (LysE YggA)
EZ55_02149	COG2897	thiosulfate sulfurtransferase activity
EZ55_02150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EZ55_02151	COG3148	PFAM DTW domain containing protein
EZ55_02156	COG0322	excinuclease ABC activity
EZ55_02157	COG2197	response regulator
EZ55_02158	COG1741	Belongs to the pirin family
EZ55_02160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZ55_02164	COG3384	dioxygenase
EZ55_02165	COG2259	Doxx family
EZ55_02166	COG0583	DNA-binding transcription factor activity
EZ55_02169	COG0670	Belongs to the BI1 family
EZ55_02170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EZ55_02173	COG2920	part of a sulfur-relay system
EZ55_02179	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZ55_02180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EZ55_02181	COG0531	amino acid
EZ55_02181	COG1674	ftsk spoiiie
EZ55_02184	COG0686	Belongs to the AlaDH PNT family
EZ55_02185	COG0284	orotidine-5'-phosphate decarboxylase activity
EZ55_02186	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EZ55_02190	COG0776	regulation of translation
EZ55_02191	COG0539	negative regulation of cytoplasmic translation
EZ55_02192	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZ55_02193	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZ55_02194	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EZ55_02196	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZ55_02197	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ55_02198	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ55_02199	COG0633	Ferredoxin
EZ55_02200	COG4221	oxidoreductase activity
EZ55_02208	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EZ55_02209	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZ55_02211	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EZ55_02213	COG4783	chaperone-mediated protein folding
EZ55_02214	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ55_02215	COG1393	Belongs to the ArsC family
EZ55_02219	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZ55_02222	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZ55_02224	COG1960	acyl-CoA dehydrogenase activity
EZ55_02229	COG0572	uridine kinase
EZ55_02230	COG3769	mannosylglycerate metabolic process
EZ55_02231	COG1215	transferase activity, transferring glycosyl groups
EZ55_02234	COG0303	'Molybdopterin
EZ55_02235	COG0534	Mate efflux family protein
EZ55_02239	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZ55_02253	COG3011	Protein conserved in bacteria
EZ55_02264	COG0405	Gamma-glutamyltransferase
EZ55_02265	COG1024	Enoyl-CoA hydratase
EZ55_02277	COG1671	Belongs to the UPF0178 family
EZ55_02278	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02279	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02280	COG1960	acyl-CoA dehydrogenase activity
EZ55_02281	COG2207	Transcriptional regulator
EZ55_02281	COG0662	Cupin 2, conserved barrel domain protein
EZ55_02284	COG1505	serine-type exopeptidase activity
EZ55_02292	COG0596	Alpha beta hydrolase
EZ55_02294	COG0716	FMN binding
EZ55_02296	COG0735	belongs to the Fur family
EZ55_02297	COG3385	transposase activity
EZ55_02299	COG1984	allophanate hydrolase subunit 2
EZ55_02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EZ55_02301	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EZ55_02302	COG2996	Protein conserved in bacteria
EZ55_02303	COG1765	OsmC-like protein
EZ55_02304	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_02309	COG0436	Aminotransferase
EZ55_02310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EZ55_02311	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZ55_02312	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZ55_02316	COG3012	SEC-C Motif Domain Protein
EZ55_02317	COG0366	Alpha amylase catalytic
EZ55_02318	COG0604	alcohol dehydrogenase
EZ55_02320	COG1960	acyl-CoA dehydrogenase activity
EZ55_02322	COG4771	TonB-dependent receptor
EZ55_02327	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZ55_02331	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EZ55_02332	COG0315	cyclic pyranopterin monophosphate synthase activity
EZ55_02333	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZ55_02334	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EZ55_02336	COG2423	ornithine cyclodeaminase activity
EZ55_02337	COG0436	Aminotransferase
EZ55_02338	COG1522	sequence-specific DNA binding
EZ55_02341	COG0826	peptidase U32
EZ55_02342	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZ55_02343	COG0436	Aminotransferase
EZ55_02344	COG3268	Saccharopine dehydrogenase
EZ55_02345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZ55_02349	COG4771	TonB-dependent receptor
EZ55_02352	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_02359	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ55_02361	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZ55_02362	COG1074	ATP-dependent DNA helicase activity
EZ55_02363	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EZ55_02365	COG1022	Amp-dependent synthetase and ligase
EZ55_02370	COG0583	DNA-binding transcription factor activity
EZ55_02374	COG0640	Transcriptional regulator
EZ55_02378	COG2204	response regulator
EZ55_02380	COG4251	negative regulation of phosphorylation
EZ55_02381	COG0784	Response regulator, receiver
EZ55_02382	COG2205	protein histidine kinase activity
EZ55_02382	COG0784	Response regulator, receiver
EZ55_02393	COG3139	Protein of unknown function (DUF1315)
EZ55_02395	COG1115	amino acid carrier protein
EZ55_02396	COG2866	Carboxypeptidase
EZ55_02400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EZ55_02402	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EZ55_02403	COG1640	4-alpha-glucanotransferase
EZ55_02405	COG0676	glucose-6-phosphate 1-epimerase activity
EZ55_02406	COG0800	Aldolase
EZ55_02408	COG0129	dihydroxy-acid dehydratase activity
EZ55_02410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EZ55_02411	COG1737	Transcriptional regulator
EZ55_02412	COG0469	pyruvate kinase activity
EZ55_02414	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_02418	COG2823	Periplasmic or secreted lipoprotein
EZ55_02424	COG3665	Urea carboxylase-associated protein
EZ55_02428	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02429	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EZ55_02431	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EZ55_02434	COG2721	sulfolactate sulfo-lyase activity
EZ55_02435	COG1904	glucuronate isomerase
EZ55_02436	COG0246	Mannitol dehydrogenase
EZ55_02437	COG0800	Aldolase
EZ55_02438	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ55_02439	COG2755	lipolytic protein G-D-S-L family
EZ55_02442	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EZ55_02448	COG2356	endonuclease I
EZ55_02453	COG0583	DNA-binding transcription factor activity
EZ55_02455	COG1979	alcohol dehydrogenase
EZ55_02456	COG1902	pentaerythritol trinitrate reductase activity
EZ55_02457	COG5001	Diguanylate cyclase
EZ55_02457	COG2203	Gaf domain
EZ55_02457	COG3706	GGDEF domain
EZ55_02457	COG4251	negative regulation of phosphorylation
EZ55_02459	COG0753	catalase activity
EZ55_02460	COG0784	Response regulator, receiver
EZ55_02460	COG3437	response regulator, receiver
EZ55_02461	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ55_02461	COG4191	Histidine kinase
EZ55_02480	COG0471	metal ion transport
EZ55_02483	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ55_02483	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ55_02484	COG0668	transmembrane transport
EZ55_02486	COG2226	methyltransferase
EZ55_02487	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ55_02488	COG1388	LysM domain
EZ55_02488	COG0741	lytic transglycosylase activity
EZ55_02492	COG3138	arginine N-succinyltransferase
EZ55_02493	COG0215	cysteine-tRNA ligase activity
EZ55_02494	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZ55_02495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ55_02497	COG2268	Band 7 protein
EZ55_02498	COG0583	DNA-binding transcription factor activity
EZ55_02499	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02502	COG1733	regulation of RNA biosynthetic process
EZ55_02503	COG0604	alcohol dehydrogenase
EZ55_02504	COG0861	Integral membrane protein TerC family
EZ55_02505	COG1063	alcohol dehydrogenase
EZ55_02506	COG0583	DNA-binding transcription factor activity
EZ55_02513	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZ55_02514	COG1286	toxin biosynthetic process
EZ55_02515	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EZ55_02516	COG0285	dihydrofolate synthase activity
EZ55_02521	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZ55_02524	COG0596	Alpha beta hydrolase
EZ55_02527	COG2819	hydrolase of the alpha beta superfamily
EZ55_02528	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZ55_02529	COG0318	PFAM AMP-dependent synthetase and ligase
EZ55_02531	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ55_02531	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EZ55_02539	COG0789	Transcriptional regulator
EZ55_02541	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02542	COG1119	ATPase activity
EZ55_02544	COG0523	cobalamin synthesis protein
EZ55_02546	COG2031	fatty acid transporter
EZ55_02547	COG0784	Response regulator, receiver
EZ55_02547	COG2205	protein histidine kinase activity
EZ55_02547	COG5002	protein histidine kinase activity
EZ55_02548	COG0612	Peptidase, M16
EZ55_02551	COG3101	peptidyl-lysine hydroxylation
EZ55_02557	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZ55_02557	COG1902	pentaerythritol trinitrate reductase activity
EZ55_02562	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZ55_02564	COG4399	Belongs to the UPF0754 family
EZ55_02571	COG2186	Transcriptional regulator
EZ55_02573	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EZ55_02574	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ55_02575	COG2983	Belongs to the UPF0260 family
EZ55_02576	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZ55_02579	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZ55_02580	COG0318	PFAM AMP-dependent synthetase and ligase
EZ55_02581	COG2267	carboxylic ester hydrolase activity
EZ55_02584	COG1214	PFAM Peptidase M22, glycoprotease
EZ55_02585	COG1199	ATP-dependent helicase activity
EZ55_02603	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZ55_02604	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZ55_02605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZ55_02606	COG0131	Imidazoleglycerol-phosphate dehydratase
EZ55_02606	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZ55_02607	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZ55_02613	COG2116	formate transmembrane transporter activity
EZ55_02614	COG0612	Peptidase, M16
EZ55_02615	COG0681	Belongs to the peptidase S26 family
EZ55_02622	COG3385	transposase activity
EZ55_02623	COG0326	Molecular chaperone. Has ATPase activity
EZ55_02624	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EZ55_02629	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZ55_02630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZ55_02633	COG3220	belongs to the UPF0276 family
EZ55_02641	COG1183	phosphatidylcholine synthase activity
EZ55_02645	COG0277	FAD linked oxidase domain protein
EZ55_02646	COG0277	FAD linked oxidase domain protein
EZ55_02647	COG1620	l-lactate permease
EZ55_02651	COG0542	response to heat
EZ55_02656	COG1595	DNA-templated transcription, initiation
EZ55_02659	COG4221	oxidoreductase activity
EZ55_02662	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZ55_02664	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EZ55_02666	COG0142	geranyltranstransferase activity
EZ55_02668	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EZ55_02669	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EZ55_02671	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZ55_02674	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZ55_02674	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZ55_02677	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ55_02678	COG0488	(ABC) transporter
EZ55_02680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EZ55_02682	COG0560	Phosphoserine phosphatase
EZ55_02684	COG0084	hydrolase, TatD family'
EZ55_02687	COG0571	ribonuclease III activity
EZ55_02693	COG1595	DNA-templated transcription, initiation
EZ55_02694	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZ55_02697	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EZ55_02701	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EZ55_02713	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZ55_02714	COG1047	Peptidyl-prolyl cis-trans
EZ55_02716	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZ55_02717	COG0196	riboflavin kinase activity
EZ55_02718	COG0728	peptidoglycan biosynthetic process
EZ55_02719	COG0268	Binds directly to 16S ribosomal RNA
EZ55_02723	COG0385	Bile acid
EZ55_02724	COG0583	DNA-binding transcription factor activity
EZ55_02729	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ55_02730	COG0776	regulation of translation
EZ55_02731	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZ55_02732	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZ55_02733	COG0740	serine-type endopeptidase activity
EZ55_02734	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZ55_02745	COG1720	tRNA m6t6A37 methyltransferase activity
EZ55_02747	COG1234	tRNA 3'-trailer cleavage
EZ55_02749	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZ55_02752	COG0516	GMP reductase activity
EZ55_02752	COG0517	IMP dehydrogenase activity
EZ55_02753	COG1570	exodeoxyribonuclease VII activity
EZ55_02757	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ55_02758	COG2976	Protein conserved in bacteria
EZ55_02762	COG3063	Type IV pilus biogenesis stability protein PilW
EZ55_02763	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZ55_02765	COG2166	iron-sulfur cluster assembly
EZ55_02768	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZ55_02769	COG0719	Fe-S assembly protein
EZ55_02770	COG0396	ATPase activity
EZ55_02771	COG0719	Fe-S assembly protein
EZ55_02772	COG1104	cysteine desulfurase activity
EZ55_02773	COG1959	2 iron, 2 sulfur cluster binding
EZ55_02775	COG2072	flavoprotein involved in K transport
EZ55_02776	COG1045	serine acetyltransferase
EZ55_02777	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EZ55_02778	COG0483	inositol monophosphate 1-phosphatase activity
EZ55_02780	COG3279	Response regulator of the LytR AlgR family
EZ55_02781	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZ55_02782	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZ55_02783	COG1862	Preprotein translocase
EZ55_02784	COG0343	queuine tRNA-ribosyltransferase activity
EZ55_02787	COG3789	protein conserved in bacteria
EZ55_02788	COG1842	Phage shock protein A
EZ55_02789	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZ55_02793	COG0754	glutathionylspermidine amidase activity
EZ55_02799	COG2066	Belongs to the glutaminase family
EZ55_02800	COG1785	Belongs to the alkaline phosphatase family
EZ55_02801	COG0745	RESPONSE REGULATOR receiver
EZ55_02814	COG3328	transposase activity
EZ55_02819	COG0438	transferase activity, transferring glycosyl groups
EZ55_02822	COG0367	asparagine synthase
EZ55_02823	COG0438	transferase activity, transferring glycosyl groups
EZ55_02829	COG2244	polysaccharide biosynthetic process
EZ55_02841	COG0489	protein tyrosine kinase activity
EZ55_02843	COG3409	Peptidoglycan-binding domain 1 protein
EZ55_02843	COG3267	Type II secretory pathway component ExeA
EZ55_02844	COG2827	Endonuclease containing a URI domain
EZ55_02848	COG1560	Kdo2-lipid A biosynthetic process
EZ55_02851	COG1960	acyl-CoA dehydrogenase activity
EZ55_02857	COG1435	thymidine kinase activity
EZ55_02860	COG1609	Transcriptional regulator
EZ55_02861	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EZ55_02865	COG1082	Xylose isomerase domain protein TIM barrel
EZ55_02866	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EZ55_02867	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ55_02870	COG1982	Orn Lys Arg decarboxylase major
EZ55_02876	COG1012	belongs to the aldehyde dehydrogenase family
EZ55_02880	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EZ55_02881	COG0789	Transcriptional regulator
EZ55_02885	COG3328	transposase activity
EZ55_02886	COG3706	GGDEF domain
EZ55_02889	COG1960	acyl-CoA dehydrogenase activity
EZ55_02901	COG2080	2 iron, 2 sulfur cluster binding
EZ55_02902	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZ55_02903	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZ55_02912	COG0601	transmembrane transport
EZ55_02913	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZ55_02914	COG4172	Belongs to the ABC transporter superfamily
EZ55_02915	COG1028	Short-chain dehydrogenase reductase Sdr
EZ55_02918	COG4221	oxidoreductase activity
EZ55_02919	COG0693	protein deglycase activity
EZ55_02921	COG1295	ribonuclease BN
EZ55_02923	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ55_02925	COG3279	Response regulator of the LytR AlgR family
EZ55_02926	COG2207	Transcriptional regulator
EZ55_02927	COG1073	alpha beta
EZ55_02928	COG1073	alpha beta
EZ55_02935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZ55_02943	COG3547	Transposase (IS116 IS110 IS902 family)
EZ55_02946	COG0339	signal peptide processing
EZ55_02954	COG0514	ATP-dependent DNA helicase (RecQ)
EZ55_02959	COG4251	negative regulation of phosphorylation
EZ55_02960	COG2133	pyrroloquinoline quinone binding
EZ55_02966	COG1484	DNA-dependent DNA replication
EZ55_02968	COG2801	Transposase and inactivated derivatives
EZ55_02970	COG4584	PFAM Integrase catalytic
EZ55_02976	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZ55_02976	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZ55_02979	COG0738	Major facilitator superfamily
EZ55_02980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZ55_02982	COG2971	BadF BadG BcrA BcrD
EZ55_02987	COG0583	DNA-binding transcription factor activity
EZ55_02993	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ55_02994	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ55_02995	COG0006	proline dipeptidase activity
EZ55_02998	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ55_03000	COG2205	protein histidine kinase activity
EZ55_03001	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EZ55_03002	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EZ55_03003	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZ55_03012	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ55_03013	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZ55_03014	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EZ55_03018	COG3577	Aspartyl protease
EZ55_03019	COG0157	Belongs to the NadC ModD family
EZ55_03021	COG1459	type II secretion system
EZ55_03022	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EZ55_03023	COG0237	dephospho-CoA kinase activity
EZ55_03023	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EZ55_03024	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EZ55_03025	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EZ55_03026	COG3608	succinylglutamate desuccinylase aspartoacylase
EZ55_03027	COG0840	transmembrane signaling receptor activity
EZ55_03028	COG4566	intracellular signal transduction
EZ55_03031	COG0643	Histidine kinase
EZ55_03031	COG2198	Histidine kinase
EZ55_03033	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZ55_03035	COG2201	protein-glutamate methylesterase activity
EZ55_03036	COG0835	chemotaxis
EZ55_03037	COG0840	transmembrane signaling receptor activity
EZ55_03038	COG0494	nUDIX hydrolase
EZ55_03040	COG0739	heme binding
EZ55_03041	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EZ55_03042	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZ55_03043	COG0849	cell division
EZ55_03044	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZ55_03045	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZ55_03048	COG0772	Belongs to the SEDS family
EZ55_03049	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZ55_03051	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EZ55_03052	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZ55_03053	COG0768	penicillin binding
EZ55_03054	COG3116	cell division
EZ55_03056	COG2001	Belongs to the MraZ family
EZ55_03060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_03061	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_03066	COG0678	peroxiredoxin activity
EZ55_03066	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZ55_03071	COG2204	response regulator
EZ55_03072	COG2198	Histidine kinase
EZ55_03072	COG0784	Response regulator, receiver
EZ55_03072	COG5002	protein histidine kinase activity
EZ55_03076	COG0668	transmembrane transport
EZ55_03077	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EZ55_03078	COG0189	ligase activity
EZ55_03079	COG1678	Uncharacterized ACR, COG1678
EZ55_03080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZ55_03085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EZ55_03086	COG0762	integral membrane protein
EZ55_03088	COG1902	pentaerythritol trinitrate reductase activity
EZ55_03088	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZ55_03095	COG1764	response to oxidative stress
EZ55_03096	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ55_03098	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EZ55_03100	COG2814	Major facilitator Superfamily
EZ55_03103	COG1960	acyl-CoA dehydrogenase activity
EZ55_03105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZ55_03110	COG0318	PFAM AMP-dependent synthetase and ligase
EZ55_03115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EZ55_03117	COG0083	homoserine kinase activity
EZ55_03119	COG0583	DNA-binding transcription factor activity
EZ55_03122	COG2197	response regulator
EZ55_03123	COG4585	Histidine kinase
EZ55_03126	COG0640	Transcriptional regulator
EZ55_03128	COG0431	NADPH-dependent FMN reductase
EZ55_03129	COG0798	PFAM Bile acid sodium symporter
EZ55_03130	COG2201	protein-glutamate methylesterase activity
EZ55_03131	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EZ55_03133	COG0642	Histidine kinase
EZ55_03137	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EZ55_03139	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZ55_03144	COG1748	Saccharopine dehydrogenase
EZ55_03148	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EZ55_03149	COG3107	peptidoglycan biosynthetic process
EZ55_03153	COG2823	Periplasmic or secreted lipoprotein
EZ55_03157	COG4585	Histidine kinase
EZ55_03158	COG2197	response regulator
EZ55_03161	COG4771	TonB-dependent receptor
EZ55_03164	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EZ55_03165	COG0372	Belongs to the citrate synthase family
EZ55_03166	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EZ55_03167	COG2828	Protein conserved in bacteria
EZ55_03168	COG2199	diguanylate cyclase activity
EZ55_03168	COG2203	Gaf domain
EZ55_03172	COG5002	protein histidine kinase activity
EZ55_03172	COG2198	Histidine kinase
EZ55_03172	COG0784	Response regulator, receiver
EZ55_03174	COG0067	glutamate synthase
EZ55_03174	COG0069	glutamate synthase activity
EZ55_03174	COG0070	glutamate synthase
EZ55_03175	COG0493	'glutamate synthase
EZ55_03179	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EZ55_03180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EZ55_03181	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZ55_03182	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZ55_03185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ55_03186	COG5507	3-demethylubiquinone-9 3-methyltransferase
EZ55_03190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZ55_03191	COG0739	heme binding
EZ55_03191	COG0741	lytic transglycosylase activity
EZ55_03191	COG1196	nuclear chromosome segregation
EZ55_03192	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EZ55_03194	COG0738	Major facilitator superfamily
EZ55_03200	COG0625	glutathione transferase activity
EZ55_03204	COG2894	cell division
EZ55_03205	COG0850	regulation of cytokinetic process
EZ55_03212	COG1981	membrane
EZ55_03215	COG1914	H( )-stimulated, divalent metal cation uptake system
EZ55_03217	COG0745	RESPONSE REGULATOR receiver
EZ55_03218	COG1217	gtp-binding protein TYPA
EZ55_03220	COG0174	glutamine synthetase
EZ55_03222	COG3852	Histidine kinase
EZ55_03223	COG2204	response regulator
EZ55_03224	COG3437	response regulator, receiver
EZ55_03228	COG2202	Pas domain
EZ55_03228	COG3920	Histidine kinase
EZ55_03234	COG0525	valine-tRNA ligase activity
EZ55_03235	COG2927	DNA polymerase III (CHI subunit)
EZ55_03236	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZ55_03237	COG0795	lipopolysaccharide-transporting ATPase activity
EZ55_03238	COG0795	lipopolysaccharide-transporting ATPase activity
EZ55_03255	COG2963	transposase activity
EZ55_03270	COG1960	acyl-CoA dehydrogenase activity
EZ55_03272	COG1022	Amp-dependent synthetase and ligase
EZ55_03273	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ55_03273	COG1024	Enoyl-CoA hydratase
EZ55_03274	COG0183	Belongs to the thiolase family
EZ55_03275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZ55_03276	COG1733	regulation of RNA biosynthetic process
EZ55_03286	COG0673	inositol 2-dehydrogenase activity
EZ55_03287	COG3292	Two component regulator propeller
EZ55_03287	COG2205	protein histidine kinase activity
EZ55_03287	COG0745	RESPONSE REGULATOR receiver
EZ55_03288	COG0628	permease
EZ55_03294	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ55_03296	COG0642	Histidine kinase
EZ55_03305	COG1971	Probably functions as a manganese efflux pump
EZ55_03309	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EZ55_03311	COG3706	GGDEF domain
EZ55_03313	COG0679	Auxin Efflux Carrier
EZ55_03319	COG1131	(ABC) transporter
EZ55_03321	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZ55_03331	COG2205	protein histidine kinase activity
EZ55_03333	COG0348	domain, Protein
EZ55_03333	COG3901	Regulator of nitric oxide reductase transcription
EZ55_03335	COG2197	response regulator
EZ55_03341	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ55_03344	COG4771	TonB-dependent receptor
EZ55_03346	COG0583	DNA-binding transcription factor activity
EZ55_03347	COG1304	FMN binding
EZ55_03348	COG0277	FAD linked oxidase domain protein
EZ55_03350	COG1462	curli production assembly transport component CsgG
EZ55_03356	COG2197	response regulator
EZ55_03359	COG0513	Belongs to the DEAD box helicase family
EZ55_03360	COG3264	Mechanosensitive ion channel
EZ55_03360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EZ55_03364	COG2202	Pas domain
EZ55_03364	COG2200	EAL domain
EZ55_03364	COG2199	diguanylate cyclase activity
EZ55_03369	COG0730	response to heat
EZ55_03370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZ55_03373	COG4191	Histidine kinase
EZ55_03375	COG0417	DNA replication proofreading
EZ55_03377	COG0318	PFAM AMP-dependent synthetase and ligase
EZ55_03388	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ55_03390	COG1573	uracil-dna glycosylase
EZ55_03391	COG3300	MHYT domain
EZ55_03391	COG5001	Diguanylate cyclase
EZ55_03395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZ55_03399	COG1983	PspC domain protein
EZ55_03400	COG1842	Phage shock protein A
EZ55_03402	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ55_03405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZ55_03409	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EZ55_03410	COG0204	Acyl-transferase
EZ55_03411	COG0204	Acyl-transferase
EZ55_03412	COG0668	transmembrane transport
EZ55_03415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZ55_03416	COG0733	neurotransmitter:sodium symporter activity
EZ55_03419	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ55_03422	COG0716	FMN binding
EZ55_03424	COG0848	biopolymer transport protein
EZ55_03426	COG0457	Tetratricopeptide repeat
EZ55_03427	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EZ55_03432	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EZ55_03433	COG0702	epimerase
EZ55_03436	COG5001	Diguanylate cyclase
EZ55_03436	COG5002	protein histidine kinase activity
EZ55_03438	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EZ55_03441	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ55_03443	COG0583	DNA-binding transcription factor activity
EZ55_03444	COG0121	glutamine amidotransferase
EZ55_03447	COG4682	membrane
EZ55_03451	COG1953	Uracil, thiamine, allantoin
EZ55_03452	COG4771	TonB-dependent receptor
EZ55_03454	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZ55_03455	COG0778	Nitroreductase
EZ55_03456	COG0596	Alpha beta hydrolase
EZ55_03457	COG0251	oxidation-reduction process
EZ55_03458	COG1335	isochorismatase
EZ55_03459	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ55_03460	COG1309	transcriptional regulator
EZ55_03463	COG4628	conserved protein (DUF2132)
EZ55_03464	COG2610	gluconate transmembrane transporter activity
EZ55_03465	COG3265	gluconokinase activity
EZ55_03466	COG1609	Transcriptional regulator
EZ55_03467	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ55_03469	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZ55_03473	COG1477	protein flavinylation
EZ55_03474	COG2871	sodium ion transport
EZ55_03475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZ55_03476	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZ55_03477	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZ55_03478	COG1805	sodium ion transport
EZ55_03479	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZ55_03480	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZ55_03481	COG0545	Peptidyl-prolyl cis-trans isomerase
EZ55_03482	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZ55_03483	COG0039	L-malate dehydrogenase activity
EZ55_03484	COG1438	arginine binding
EZ55_03489	COG0572	uridine kinase
EZ55_03490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EZ55_03493	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EZ55_03497	COG0516	GMP reductase activity
EZ55_03497	COG0517	IMP dehydrogenase activity
EZ55_03498	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZ55_03502	COG0189	ligase activity
EZ55_03504	COG0189	ligase activity
EZ55_03504	COG4067	protein conserved in archaea
EZ55_03507	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZ55_03509	COG1283	sodium-dependent phosphate transmembrane transporter activity
EZ55_03510	COG0667	Aldo Keto reductase
EZ55_03522	COG0753	catalase activity
EZ55_03525	COG5001	Diguanylate cyclase
EZ55_03531	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EZ55_03533	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZ55_03534	COG0840	transmembrane signaling receptor activity
EZ55_03543	COG0583	DNA-binding transcription factor activity
EZ55_03550	COG1216	Glycosyl transferase, family 2
EZ55_03550	COG0438	transferase activity, transferring glycosyl groups
EZ55_03556	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ55_03557	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ55_03558	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ55_03563	COG0463	Glycosyl transferase, family 2
EZ55_03564	COG2089	acid synthase
EZ55_03567	COG1083	cytidylyl-transferase
EZ55_03568	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EZ55_03569	COG1086	Polysaccharide biosynthesis protein
EZ55_03574	COG0202	RNA polymerase activity
EZ55_03580	COG0201	protein transport
EZ55_03584	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZ55_03591	COG5002	protein histidine kinase activity
EZ55_03591	COG0784	Response regulator, receiver
EZ55_03594	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ55_03595	COG0557	exoribonuclease II activity
EZ55_03601	COG4771	TonB-dependent receptor
EZ55_03604	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EZ55_03608	COG2234	aminopeptidase activity
EZ55_03610	COG4251	negative regulation of phosphorylation
EZ55_03614	COG1271	oxidase subunit
EZ55_03615	COG1294	oxidase, subunit
EZ55_03617	COG1522	sequence-specific DNA binding
EZ55_03620	COG1278	Cold shock
EZ55_03621	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZ55_03623	COG2226	methyltransferase
EZ55_03625	COG0339	signal peptide processing
EZ55_03626	COG2201	protein-glutamate methylesterase activity
EZ55_03630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ55_03631	COG0243	molybdopterin cofactor binding
EZ55_03634	COG1506	peptidase
EZ55_03634	COG0823	Involved in the tonB-independent uptake of proteins
EZ55_03634	COG4946	Tricorn protease homolog
EZ55_03644	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ55_03646	COG2197	response regulator
EZ55_03651	COG3385	transposase activity
EZ55_03653	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EZ55_03654	COG1278	Cold shock
EZ55_03656	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZ55_03657	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EZ55_03660	COG0281	malic enzyme
EZ55_03662	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EZ55_03668	COG0456	acetyltransferase
EZ55_03670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EZ55_03671	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EZ55_03672	COG2177	Part of the ABC transporter FtsEX involved in
EZ55_03673	COG2884	Cell division ATP-binding protein ftsE
EZ55_03674	COG0552	protein localization to endoplasmic reticulum
EZ55_03675	COG0742	ribosomal rna small subunit methyltransferase
EZ55_03677	COG2095	MarC family integral membrane protein
EZ55_03681	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EZ55_03682	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZ55_03683	COG0617	tRNA 3'-terminal CCA addition
EZ55_03684	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZ55_03687	COG0076	glutamate decarboxylase activity
EZ55_03690	COG0842	Transport permease protein
EZ55_03691	COG1131	(ABC) transporter
EZ55_03692	COG0745	RESPONSE REGULATOR receiver
EZ55_03693	COG2205	protein histidine kinase activity
EZ55_03698	COG1253	flavin adenine dinucleotide binding
EZ55_03699	COG0701	Predicted permease
EZ55_03700	COG1966	Carbon starvation protein
EZ55_03710	COG0848	biopolymer transport protein
EZ55_03712	COG0811	peptide transport
EZ55_03716	COG3128	pkhd-type hydroxylase
EZ55_03721	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZ55_03722	COG0049	tRNA binding
EZ55_03723	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EZ55_03724	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZ55_03725	COG0085	RNA polymerase activity
EZ55_03726	COG0222	ribosome binding
EZ55_03727	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZ55_03728	COG0081	regulation of translation
EZ55_03729	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZ55_03732	COG0250	Participates in transcription elongation, termination and antitermination
EZ55_03733	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZ55_03735	COG1132	(ABC) transporter
EZ55_03736	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZ55_03737	COG3590	peptidase
EZ55_03740	COG0513	Belongs to the DEAD box helicase family
EZ55_03742	COG0418	dihydroorotase activity
EZ55_03743	COG3040	lipid binding
EZ55_03744	COG4989	oxidoreductase activity
EZ55_03745	COG0346	lactoylglutathione lyase activity
EZ55_03746	COG0668	transmembrane transport
EZ55_03751	COG0302	gtp cyclohydrolase
EZ55_03753	COG2957	Belongs to the agmatine deiminase family
EZ55_03754	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ55_03756	COG1201	RNA secondary structure unwinding
EZ55_03757	COG2311	Membrane
EZ55_03760	COG1793	dna ligase
EZ55_03761	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZ55_03762	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ55_03767	COG0625	glutathione transferase activity
EZ55_03768	COG0625	glutathione transferase activity
EZ55_03770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EZ55_03773	COG1012	belongs to the aldehyde dehydrogenase family
EZ55_03774	COG0028	Belongs to the TPP enzyme family
EZ55_03776	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZ55_03777	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EZ55_03778	COG0330	HflC and HflK could
EZ55_03779	COG0330	HflC and HflK could
EZ55_03780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZ55_03781	COG1923	regulation of RNA biosynthetic process
EZ55_03782	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZ55_03785	COG0802	atpase or kinase
EZ55_03786	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EZ55_03786	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EZ55_03787	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZ55_03791	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EZ55_03792	COG0735	belongs to the Fur family
EZ55_03796	COG0305	Participates in initiation and elongation during chromosome replication
EZ55_03801	COG2258	MOSC domain
EZ55_03815	COG0840	transmembrane signaling receptor activity
EZ55_03816	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ55_03816	COG4191	Histidine kinase
EZ55_03817	COG0840	transmembrane signaling receptor activity
EZ55_03820	COG2855	membrane
EZ55_03822	COG0656	L-ascorbic acid biosynthetic process
EZ55_03826	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZ55_03827	COG4771	TonB-dependent receptor
EZ55_03831	COG3706	GGDEF domain
EZ55_03832	COG1757	Na H antiporter
EZ55_03833	COG1472	Belongs to the glycosyl hydrolase 3 family
EZ55_03835	COG2723	6-phospho-beta-galactosidase activity
EZ55_03836	COG1609	Transcriptional regulator
EZ55_03837	COG0477	Major facilitator Superfamily
EZ55_03837	COG2814	Major facilitator Superfamily
EZ55_03838	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EZ55_03839	COG4988	ABC transporter
EZ55_03840	COG4890	Cyd operon protein YbgT
EZ55_03841	COG1294	oxidase, subunit
EZ55_03849	COG4319	ketosteroid isomerase
EZ55_03851	COG4771	TonB-dependent receptor
EZ55_03854	COG1469	GTP cyclohydrolase I activity
EZ55_03865	COG3237	CsbD-like
EZ55_03868	COG1595	DNA-templated transcription, initiation
EZ55_03874	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZ55_03874	COG0596	Alpha beta hydrolase
EZ55_03879	COG3038	cytochrome b561
EZ55_03881	COG1252	NADH dehydrogenase
EZ55_03882	COG4206	TonB-dependent receptor
EZ55_03885	COG0583	DNA-binding transcription factor activity
EZ55_03886	COG2067	long-chain fatty acid transport protein
EZ55_03887	COG2130	NADP-dependent
EZ55_03888	COG5001	Diguanylate cyclase
EZ55_03888	COG4251	negative regulation of phosphorylation
EZ55_03888	COG3706	GGDEF domain
EZ55_03888	COG2203	Gaf domain
EZ55_03889	COG0784	Response regulator, receiver
EZ55_03889	COG2205	protein histidine kinase activity
EZ55_03891	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ55_03892	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ55_03893	COG1349	DNA-binding transcription factor activity
EZ55_03894	COG0673	inositol 2-dehydrogenase activity
EZ55_03897	COG0697	spore germination
EZ55_03898	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZ55_03899	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EZ55_03900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ55_03901	COG1166	arginine decarboxylase activity
EZ55_03903	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EZ55_03919	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ55_03921	COG0109	protoheme IX farnesyltransferase activity
EZ55_03925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZ55_03933	COG3328	transposase activity
EZ55_03941	COG1324	tolerance protein
EZ55_03942	COG4232	protein-disulfide reductase activity
EZ55_03943	COG0739	heme binding
EZ55_03945	COG0511	ligase activity, forming carbon-carbon bonds
EZ55_03946	COG0439	Biotin carboxylase
EZ55_03954	COG0154	amidase activity
EZ55_03957	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ55_03958	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EZ55_03961	COG0151	Belongs to the GarS family
EZ55_03964	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ55_03965	COG3954	Phosphoribulokinase
EZ55_03970	COG1501	Belongs to the glycosyl hydrolase 31 family
EZ55_03971	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EZ55_03972	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EZ55_03974	COG3031	protein transport across the cell outer membrane
EZ55_03976	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ55_03977	COG1459	type II secretion system
EZ55_03978	COG2165	general secretion pathway protein
EZ55_03979	COG2165	general secretion pathway protein
EZ55_03980	COG2165	general secretion pathway protein
EZ55_03981	COG4795	General secretion pathway protein
EZ55_03984	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EZ55_03988	COG1012	belongs to the aldehyde dehydrogenase family
EZ55_03990	COG1011	Hydrolase
EZ55_03991	COG0494	nUDIX hydrolase
EZ55_03992	COG1218	3'(2'),5'-bisphosphate nucleotidase
EZ55_03994	COG2943	transferase activity, transferring hexosyl groups
EZ55_03995	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EZ55_03997	COG3089	Belongs to the UPF0270 family
EZ55_03998	COG0429	hydrolase of the alpha beta-hydrolase fold
EZ55_04000	COG0488	(ABC) transporter
EZ55_04006	COG0545	Peptidyl-prolyl cis-trans isomerase
EZ55_04008	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZ55_04009	COG2183	response to ionizing radiation
EZ55_04014	COG1609	Transcriptional regulator
EZ55_04014	COG2207	Transcriptional regulator
EZ55_04015	COG2211	Major facilitator Superfamily
EZ55_04020	COG3693	PFAM glycoside hydrolase, family 10
EZ55_04021	COG0667	Aldo Keto reductase
EZ55_04022	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZ55_04023	COG2115	Belongs to the xylose isomerase family
EZ55_04024	COG1070	Carbohydrate kinase
EZ55_04027	COG1472	Belongs to the glycosyl hydrolase 3 family
EZ55_04028	COG0477	Major facilitator Superfamily
EZ55_04036	COG0596	Alpha beta hydrolase
EZ55_04037	COG1040	competence protein
EZ55_04040	COG1794	racemase activity, acting on amino acids and derivatives
EZ55_04043	COG0534	Mate efflux family protein
EZ55_04046	COG1999	signal sequence binding
EZ55_04047	COG0109	protoheme IX farnesyltransferase activity
EZ55_04048	COG1612	heme a metabolic process
EZ55_04053	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EZ55_04054	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZ55_04055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZ55_04058	COG3706	GGDEF domain
EZ55_04061	COG0129	dihydroxy-acid dehydratase activity
EZ55_04062	COG2860	membrane
EZ55_04063	COG0606	chelatase, subunit chli
EZ55_04064	COG0583	DNA-binding transcription factor activity
EZ55_04066	COG2814	Major facilitator Superfamily
EZ55_04068	COG0729	surface antigen
EZ55_04069	COG2911	Protein conserved in bacteria
EZ55_04074	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZ55_04076	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZ55_04081	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZ55_04086	COG1228	amidohydrolase
EZ55_04090	COG0425	Belongs to the sulfur carrier protein TusA family
EZ55_04093	COG1561	YicC-like family, N-terminal region
EZ55_04094	COG3620	sequence-specific DNA binding
EZ55_04100	COG2211	Major facilitator Superfamily
EZ55_04101	COG1609	Transcriptional regulator
EZ55_04105	COG2199	diguanylate cyclase activity
EZ55_04105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EZ55_04110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZ55_04114	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZ55_04115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZ55_04119	COG1475	DNA binding
EZ55_04120	COG1192	Involved in chromosome partitioning
EZ55_04125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZ55_04126	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EZ55_04128	COG0706	membrane insertase activity
EZ55_04129	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EZ55_04130	COG0594	ribonuclease P activity
EZ55_04131	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZ55_04132	COG1192	Involved in chromosome partitioning
EZ55_04149	COG5002	protein histidine kinase activity
EZ55_04150	COG0745	RESPONSE REGULATOR receiver
EZ55_04155	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ55_04171	COG1017	nitric oxide dioxygenase activity
EZ55_04171	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZ55_04175	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EZ55_04181	COG0375	protein maturation
EZ55_04183	COG0409	Hydrogenase expression formation protein
EZ55_04185	COG0309	Hydrogenase expression formation protein (HypE)
EZ55_04187	COG2217	Heavy metal translocating P-type atpase
EZ55_04203	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZ55_04205	COG0789	Transcriptional regulator
EZ55_04206	COG2217	Heavy metal translocating P-type atpase
EZ55_04218	COG3550	peptidyl-serine autophosphorylation
EZ55_04219	COG1396	sequence-specific DNA binding
EZ55_04244	COG1484	DNA-dependent DNA replication
EZ55_04245	COG4584	PFAM Integrase catalytic
EZ55_04246	COG4584	PFAM Integrase catalytic
EZ55_04257	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EZ55_04258	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZ55_04268	COG2963	transposase activity
EZ55_04272	COG3344	reverse transcriptase
EZ55_04275	COG3344	reverse transcriptase
EZ55_04289	COG0784	Response regulator, receiver
EZ55_04289	COG2205	protein histidine kinase activity
EZ55_04291	COG2801	Transposase and inactivated derivatives
EZ55_04297	COG0840	transmembrane signaling receptor activity
EZ55_04298	COG2801	Transposase and inactivated derivatives
EZ55_04301	COG2201	protein-glutamate methylesterase activity
EZ55_04313	COG2059	Chromate
EZ55_04337	COG0789	Transcriptional regulator
EZ55_04339	COG3209	COG3209 Rhs family protein
EZ55_04346	COG0531	amino acid
EZ55_04350	COG2801	Transposase and inactivated derivatives