locus-tag	class	description
NFG60_00010	COG1953	Uracil, thiamine, allantoin
NFG60_00015	COG4771	TonB-dependent receptor
NFG60_00025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NFG60_00030	COG0778	Nitroreductase
NFG60_00035	COG0596	Alpha beta hydrolase
NFG60_00040	COG0251	oxidation-reduction process
NFG60_00045	COG1335	isochorismatase
NFG60_00050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFG60_00055	COG1309	transcriptional regulator
NFG60_00070	COG4628	conserved protein (DUF2132)
NFG60_00080	COG3265	gluconokinase activity
NFG60_00085	COG1609	Transcriptional regulator
NFG60_00090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NFG60_00100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NFG60_00110	COG1477	protein flavinylation
NFG60_00115	COG2871	sodium ion transport
NFG60_00120	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NFG60_00125	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NFG60_00130	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NFG60_00135	COG1805	sodium ion transport
NFG60_00140	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NFG60_00145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NFG60_00150	COG0545	Peptidyl-prolyl cis-trans isomerase
NFG60_00155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NFG60_00160	COG0039	L-malate dehydrogenase activity
NFG60_00165	COG1438	arginine binding
NFG60_00190	COG0572	uridine kinase
NFG60_00195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NFG60_00210	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NFG60_00235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_00255	COG0189	ligase activity
NFG60_00265	COG0189	ligase activity
NFG60_00265	COG4067	protein conserved in archaea
NFG60_00280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NFG60_00290	COG1283	sodium-dependent phosphate transmembrane transporter activity
NFG60_00295	COG0667	Aldo Keto reductase
NFG60_00350	COG0753	catalase activity
NFG60_00395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NFG60_00405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NFG60_00460	COG0583	DNA-binding transcription factor activity
NFG60_00485	COG0438	transferase activity, transferring glycosyl groups
NFG60_00485	COG1216	Glycosyl transferase, family 2
NFG60_00535	COG1216	Glycosyl transferase, family 2
NFG60_00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFG60_00575	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NFG60_00615	COG0463	Glycosyl transferase, family 2
NFG60_00640	COG0202	RNA polymerase activity
NFG60_00665	COG0201	protein transport
NFG60_00685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NFG60_00720	COG5002	protein histidine kinase activity
NFG60_00720	COG0784	Response regulator, receiver
NFG60_00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NFG60_00740	COG0557	exoribonuclease II activity
NFG60_00765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NFG60_00785	COG2234	aminopeptidase activity
NFG60_00795	COG4251	negative regulation of phosphorylation
NFG60_00820	COG1271	oxidase subunit
NFG60_00825	COG1294	oxidase, subunit
NFG60_00840	COG1522	sequence-specific DNA binding
NFG60_00855	COG1278	Cold shock
NFG60_00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NFG60_00870	COG2226	methyltransferase
NFG60_00880	COG0339	signal peptide processing
NFG60_00885	COG2201	protein-glutamate methylesterase activity
NFG60_00895	COG3852	Histidine kinase
NFG60_00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFG60_00910	COG0243	molybdopterin cofactor binding
NFG60_00970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_00980	COG2197	response regulator
NFG60_01000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NFG60_01005	COG1278	Cold shock
NFG60_01015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NFG60_01020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NFG60_01035	COG0281	malic enzyme
NFG60_01045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NFG60_01075	COG0456	acetyltransferase
NFG60_01085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NFG60_01090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NFG60_01095	COG2177	Part of the ABC transporter FtsEX involved in
NFG60_01100	COG2884	Cell division ATP-binding protein ftsE
NFG60_01105	COG0552	protein localization to endoplasmic reticulum
NFG60_01110	COG0742	ribosomal rna small subunit methyltransferase
NFG60_01120	COG2095	MarC family integral membrane protein
NFG60_01140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NFG60_01145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NFG60_01150	COG0617	tRNA 3'-terminal CCA addition
NFG60_01155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NFG60_01170	COG0076	glutamate decarboxylase activity
NFG60_01185	COG0842	Transport permease protein
NFG60_01190	COG1131	(ABC) transporter
NFG60_01195	COG0745	RESPONSE REGULATOR receiver
NFG60_01200	COG2205	protein histidine kinase activity
NFG60_01220	COG1253	flavin adenine dinucleotide binding
NFG60_01225	COG0701	Predicted permease
NFG60_01230	COG1966	Carbon starvation protein
NFG60_01280	COG0848	biopolymer transport protein
NFG60_01290	COG0811	peptide transport
NFG60_01310	COG3128	pkhd-type hydroxylase
NFG60_01315	COG4774	siderophore transport
NFG60_01335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NFG60_01340	COG0049	tRNA binding
NFG60_01345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NFG60_01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NFG60_01355	COG0085	RNA polymerase activity
NFG60_01360	COG0222	ribosome binding
NFG60_01365	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NFG60_01370	COG0081	regulation of translation
NFG60_01375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NFG60_01385	COG0250	Participates in transcription elongation, termination and antitermination
NFG60_01390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NFG60_01400	COG1132	(ABC) transporter
NFG60_01405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NFG60_01410	COG3590	peptidase
NFG60_01425	COG0513	Belongs to the DEAD box helicase family
NFG60_01435	COG0418	dihydroorotase activity
NFG60_01440	COG3040	lipid binding
NFG60_01445	COG4989	oxidoreductase activity
NFG60_01450	COG0346	lactoylglutathione lyase activity
NFG60_01455	COG0668	transmembrane transport
NFG60_01475	COG0302	gtp cyclohydrolase
NFG60_01485	COG2957	Belongs to the agmatine deiminase family
NFG60_01490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NFG60_01505	COG1201	RNA secondary structure unwinding
NFG60_01510	COG2311	Membrane
NFG60_01525	COG1793	dna ligase
NFG60_01530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NFG60_01535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFG60_01560	COG0625	glutathione transferase activity
NFG60_01565	COG0625	glutathione transferase activity
NFG60_01575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NFG60_01590	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_01595	COG0028	Belongs to the TPP enzyme family
NFG60_01610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NFG60_01615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NFG60_01620	COG0330	HflC and HflK could
NFG60_01625	COG0330	HflC and HflK could
NFG60_01630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NFG60_01635	COG1923	regulation of RNA biosynthetic process
NFG60_01640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NFG60_01655	COG0802	atpase or kinase
NFG60_01660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NFG60_01660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NFG60_01665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NFG60_01685	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NFG60_01690	COG0735	belongs to the Fur family
NFG60_01710	COG0305	Participates in initiation and elongation during chromosome replication
NFG60_01735	COG2258	MOSC domain
NFG60_01805	COG0840	transmembrane signaling receptor activity
NFG60_01810	COG4191	Histidine kinase
NFG60_01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_01815	COG0840	transmembrane signaling receptor activity
NFG60_01830	COG2855	membrane
NFG60_01840	COG0656	L-ascorbic acid biosynthetic process
NFG60_01860	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_01865	COG4771	TonB-dependent receptor
NFG60_01890	COG3706	GGDEF domain
NFG60_01895	COG1757	Na H antiporter
NFG60_01900	COG1472	Belongs to the glycosyl hydrolase 3 family
NFG60_01910	COG2723	6-phospho-beta-galactosidase activity
NFG60_01915	COG1609	Transcriptional regulator
NFG60_01920	COG2814	Major facilitator Superfamily
NFG60_01920	COG0477	Major facilitator Superfamily
NFG60_01925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NFG60_01930	COG4988	ABC transporter
NFG60_01935	COG4890	Cyd operon protein YbgT
NFG60_01940	COG1294	oxidase, subunit
NFG60_01975	COG4319	ketosteroid isomerase
NFG60_01980	COG1335	isochorismatase
NFG60_01985	COG2863	cytochrome
NFG60_01990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NFG60_01995	COG1741	Belongs to the pirin family
NFG60_02005	COG4771	TonB-dependent receptor
NFG60_02020	COG1469	GTP cyclohydrolase I activity
NFG60_02075	COG3237	CsbD-like
NFG60_02090	COG1595	DNA-templated transcription, initiation
NFG60_02120	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFG60_02120	COG0596	Alpha beta hydrolase
NFG60_02145	COG3038	cytochrome b561
NFG60_02155	COG1252	NADH dehydrogenase
NFG60_02160	COG4206	TonB-dependent receptor
NFG60_02175	COG0583	DNA-binding transcription factor activity
NFG60_02180	COG2067	long-chain fatty acid transport protein
NFG60_02185	COG2130	NADP-dependent
NFG60_02275	COG3209	COG3209 Rhs family protein
NFG60_02290	COG2801	Transposase and inactivated derivatives
NFG60_02295	COG2203	Gaf domain
NFG60_02295	COG3706	GGDEF domain
NFG60_02295	COG4251	negative regulation of phosphorylation
NFG60_02295	COG5001	Diguanylate cyclase
NFG60_02300	COG2205	protein histidine kinase activity
NFG60_02300	COG0784	Response regulator, receiver
NFG60_02310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFG60_02355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NFG60_02360	COG1349	DNA-binding transcription factor activity
NFG60_02365	COG0673	inositol 2-dehydrogenase activity
NFG60_02380	COG0697	spore germination
NFG60_02385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NFG60_02390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NFG60_02395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFG60_02400	COG1166	arginine decarboxylase activity
NFG60_02410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NFG60_02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NFG60_02500	COG0109	protoheme IX farnesyltransferase activity
NFG60_02520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NFG60_02550	COG1324	tolerance protein
NFG60_02555	COG4232	protein-disulfide reductase activity
NFG60_02560	COG0739	heme binding
NFG60_02570	COG0511	ligase activity, forming carbon-carbon bonds
NFG60_02575	COG0439	Biotin carboxylase
NFG60_02620	COG0154	amidase activity
NFG60_02635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NFG60_02640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NFG60_02655	COG0151	Belongs to the GarS family
NFG60_02670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NFG60_02675	COG3954	Phosphoribulokinase
NFG60_02700	COG1501	Belongs to the glycosyl hydrolase 31 family
NFG60_02705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NFG60_02710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NFG60_02720	COG3031	protein transport across the cell outer membrane
NFG60_02730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NFG60_02735	COG1459	type II secretion system
NFG60_02740	COG2165	general secretion pathway protein
NFG60_02745	COG2165	general secretion pathway protein
NFG60_02750	COG2165	general secretion pathway protein
NFG60_02755	COG4795	General secretion pathway protein
NFG60_02770	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NFG60_02790	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_02800	COG1011	Hydrolase
NFG60_02805	COG0494	nUDIX hydrolase
NFG60_02810	COG1218	3'(2'),5'-bisphosphate nucleotidase
NFG60_02820	COG2943	transferase activity, transferring hexosyl groups
NFG60_02825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NFG60_02835	COG3089	Belongs to the UPF0270 family
NFG60_02840	COG0429	hydrolase of the alpha beta-hydrolase fold
NFG60_02850	COG0488	(ABC) transporter
NFG60_02870	COG2900	Belongs to the SlyX family
NFG60_02880	COG0545	Peptidyl-prolyl cis-trans isomerase
NFG60_02890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NFG60_02895	COG2183	response to ionizing radiation
NFG60_02915	COG0596	Alpha beta hydrolase
NFG60_02920	COG1040	competence protein
NFG60_02935	COG1794	racemase activity, acting on amino acids and derivatives
NFG60_02950	COG0534	Mate efflux family protein
NFG60_02965	COG1999	signal sequence binding
NFG60_02970	COG0109	protoheme IX farnesyltransferase activity
NFG60_02975	COG1612	heme a metabolic process
NFG60_03000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NFG60_03005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NFG60_03010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NFG60_03025	COG3706	GGDEF domain
NFG60_03040	COG0129	dihydroxy-acid dehydratase activity
NFG60_03045	COG2860	membrane
NFG60_03050	COG0606	chelatase, subunit chli
NFG60_03055	COG0583	DNA-binding transcription factor activity
NFG60_03080	COG2814	Major facilitator Superfamily
NFG60_03090	COG0729	surface antigen
NFG60_03095	COG2911	Protein conserved in bacteria
NFG60_03120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NFG60_03130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NFG60_03150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NFG60_03175	COG1228	amidohydrolase
NFG60_03195	COG0425	Belongs to the sulfur carrier protein TusA family
NFG60_03210	COG1561	YicC-like family, N-terminal region
NFG60_03230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NFG60_03260	COG2211	Major facilitator Superfamily
NFG60_03265	COG1609	Transcriptional regulator
NFG60_03285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NFG60_03285	COG2199	diguanylate cyclase activity
NFG60_03310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NFG60_03330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NFG60_03335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NFG60_03355	COG1475	DNA binding
NFG60_03360	COG1192	Involved in chromosome partitioning
NFG60_03385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NFG60_03390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NFG60_03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFG60_03420	COG0706	membrane insertase activity
NFG60_03425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NFG60_03430	COG0594	ribonuclease P activity
NFG60_03435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NFG60_03455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NFG60_03490	COG2818	Glycosylase
NFG60_03500	COG3078	GTPase activator activity
NFG60_03520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NFG60_03520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NFG60_03525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NFG60_03530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NFG60_03535	COG0569	domain protein
NFG60_03540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NFG60_03540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NFG60_03545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NFG60_03560	COG0758	DNA mediated transformation
NFG60_03575	COG0009	L-threonylcarbamoyladenylate synthase
NFG60_03580	COG0408	coproporphyrinogen oxidase activity
NFG60_03585	COG3047	cAMP biosynthetic process
NFG60_03600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NFG60_03675	COG2234	aminopeptidase activity
NFG60_03685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NFG60_03710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFG60_03740	COG3642	lipopolysaccharide core region biosynthetic process
NFG60_03770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NFG60_03785	COG3161	chorismate lyase activity
NFG60_03790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NFG60_03800	COG0210	DNA helicase
NFG60_03830	COG1228	amidohydrolase
NFG60_03850	COG0436	Aminotransferase
NFG60_03860	COG0583	DNA-binding transcription factor activity
NFG60_03865	COG0471	metal ion transport
NFG60_03870	COG0596	Alpha beta hydrolase
NFG60_03875	COG0733	neurotransmitter:sodium symporter activity
NFG60_03880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NFG60_03885	COG0066	3-isopropylmalate dehydratase activity
NFG60_03895	COG1228	amidohydrolase
NFG60_03905	COG1522	sequence-specific DNA binding
NFG60_03915	COG0022	dehydrogenase e1 component
NFG60_03930	COG1960	acyl-CoA dehydrogenase activity
NFG60_03935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NFG60_03945	COG1757	Na H antiporter
NFG60_03950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NFG60_04005	COG0583	DNA-binding transcription factor activity
NFG60_04015	COG3106	COG3106 Predicted ATPase
NFG60_04030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NFG60_04045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NFG60_04050	COG0352	thiamine-phosphate diphosphorylase activity
NFG60_04060	COG3071	HemY protein
NFG60_04065	COG2959	enzyme of heme biosynthesis
NFG60_04075	COG0181	hydroxymethylbilane synthase activity
NFG60_04090	COG0194	GDP metabolic process
NFG60_04100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NFG60_04110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NFG60_04115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NFG60_04125	COG0678	peroxiredoxin activity
NFG60_04140	COG1178	ABC-type Fe3 transport system permease component
NFG60_04145	COG3842	ATPase activity
NFG60_04150	COG2081	HI0933 family
NFG60_04155	COG3047	cAMP biosynthetic process
NFG60_04170	COG2200	EAL domain
NFG60_04175	COG5001	Diguanylate cyclase
NFG60_04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_04220	COG0427	acetyl-CoA hydrolase
NFG60_04225	COG0123	including yeast histone deacetylase and acetoin utilization protein
NFG60_04240	COG0840	transmembrane signaling receptor activity
NFG60_04250	COG3064	Membrane
NFG60_04260	COG5001	Diguanylate cyclase
NFG60_04260	COG5002	protein histidine kinase activity
NFG60_04275	COG0514	ATP-dependent DNA helicase (RecQ)
NFG60_04280	COG2050	protein possibly involved in aromatic compounds catabolism
NFG60_04285	COG2239	Acts as a magnesium transporter
NFG60_04290	COG2962	Rard protein
NFG60_04295	COG3706	GGDEF domain
NFG60_04300	COG0210	DNA helicase
NFG60_04310	COG3706	GGDEF domain
NFG60_04315	COG1011	Hydrolase
NFG60_04320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NFG60_04330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NFG60_04335	COG0019	diaminopimelate decarboxylase activity
NFG60_04370	COG0163	prenyltransferase activity
NFG60_04375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NFG60_04385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NFG60_04420	COG1077	Cell shape determining protein MreB Mrl
NFG60_04430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NFG60_04435	COG2814	Major facilitator Superfamily
NFG60_04440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NFG60_04470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NFG60_04480	COG0629	single-stranded DNA binding
NFG60_04500	COG0625	glutathione transferase activity
NFG60_04505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NFG60_04505	COG1017	nitric oxide dioxygenase activity
NFG60_04530	COG0625	glutathione transferase activity
NFG60_04550	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_04575	COG1349	DNA-binding transcription factor activity
NFG60_04620	COG3267	Type II secretory pathway component ExeA
NFG60_04620	COG3409	Peptidoglycan-binding domain 1 protein
NFG60_04630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NFG60_04635	COG1459	type II secretion system
NFG60_04645	COG2165	general secretion pathway protein
NFG60_04650	COG2165	general secretion pathway protein
NFG60_04680	COG1077	Cell shape determining protein MreB Mrl
NFG60_04685	COG1792	Involved in formation and maintenance of cell shape
NFG60_04690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NFG60_04700	COG1530	ribonuclease E activity
NFG60_04710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NFG60_04715	COG0312	modulator of DNA gyrase
NFG60_04725	COG3028	Belongs to the UPF0307 family
NFG60_04730	COG0312	modulator of DNA gyrase
NFG60_04745	COG0745	RESPONSE REGULATOR receiver
NFG60_04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_04750	COG4191	Histidine kinase
NFG60_04755	COG0297	glycogen (starch) synthase activity
NFG60_04765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NFG60_04775	COG1194	a g-specific adenine glycosylase
NFG60_04845	COG0745	RESPONSE REGULATOR receiver
NFG60_04850	COG0643	Histidine kinase
NFG60_04850	COG2198	Histidine kinase
NFG60_04855	COG0835	chemotaxis
NFG60_04875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NFG60_04890	COG0745	RESPONSE REGULATOR receiver
NFG60_04895	COG0643	Histidine kinase
NFG60_04895	COG2198	Histidine kinase
NFG60_04900	COG0835	chemotaxis
NFG60_04925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NFG60_04975	COG0546	phosphoglycolate phosphatase activity
NFG60_04985	COG2205	protein histidine kinase activity
NFG60_04985	COG0784	Response regulator, receiver
NFG60_05000	COG1609	Transcriptional regulator
NFG60_05005	COG0673	inositol 2-dehydrogenase activity
NFG60_05015	COG2211	Major facilitator Superfamily
NFG60_05020	COG1082	Xylose isomerase domain protein TIM barrel
NFG60_05040	COG1454	alcohol dehydrogenase
NFG60_05095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NFG60_05115	COG0089	rRNA binding
NFG60_05125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NFG60_05135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NFG60_05150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NFG60_05160	COG1519	Transferase
NFG60_05205	COG0788	formyltetrahydrofolate deformylase activity
NFG60_05215	COG1643	Atp-dependent helicase
NFG60_05225	COG2951	lytic endotransglycosylase activity
NFG60_05230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NFG60_05240	COG2354	Protein conserved in bacteria
NFG60_05265	COG0004	ammonium transporteR
NFG60_05270	COG0405	Gamma-glutamyltransferase
NFG60_05275	COG2837	iron assimilation
NFG60_05290	COG0540	Belongs to the ATCase OTCase family
NFG60_05315	COG5002	protein histidine kinase activity
NFG60_05315	COG0784	Response regulator, receiver
NFG60_05315	COG2205	protein histidine kinase activity
NFG60_05330	COG5001	Diguanylate cyclase
NFG60_05330	COG3300	MHYT domain
NFG60_05340	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_05350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NFG60_05360	COG0512	Glutamine amidotransferase of anthranilate synthase
NFG60_05365	COG0180	Tryptophanyl-tRNA synthetase
NFG60_05370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NFG60_05390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NFG60_05400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NFG60_05435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NFG60_05440	COG0281	malic enzyme
NFG60_05450	COG0625	glutathione transferase activity
NFG60_05460	COG0753	catalase activity
NFG60_05485	COG3300	MHYT domain
NFG60_05485	COG5001	Diguanylate cyclase
NFG60_05490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NFG60_05490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NFG60_05500	COG0137	argininosuccinate synthase activity
NFG60_05520	COG1803	Methylglyoxal synthase
NFG60_05530	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NFG60_05545	COG0745	RESPONSE REGULATOR receiver
NFG60_05550	COG2205	protein histidine kinase activity
NFG60_05555	COG2267	carboxylic ester hydrolase activity
NFG60_05560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NFG60_05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_05570	COG0577	efflux transmembrane transporter activity
NFG60_05570	COG1136	(ABC) transporter
NFG60_05585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NFG60_05595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NFG60_05600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NFG60_05605	COG4942	peptidase
NFG60_05610	COG2861	carbohydrate metabolic process
NFG60_05620	COG0584	glycerophosphoryl diester phosphodiesterase
NFG60_05635	COG1162	GTPase activity
NFG60_05640	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NFG60_05665	COG0457	Tetratricopeptide repeat
NFG60_05680	COG0028	Belongs to the TPP enzyme family
NFG60_05700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NFG60_05705	COG0805	protein transport
NFG60_05715	COG0084	hydrolase, TatD family'
NFG60_05720	COG3706	GGDEF domain
NFG60_05720	COG2203	Gaf domain
NFG60_05720	COG4251	negative regulation of phosphorylation
NFG60_05720	COG5001	Diguanylate cyclase
NFG60_05730	COG0248	Ppx GppA phosphatase
NFG60_05735	COG0513	Belongs to the DEAD box helicase family
NFG60_05740	COG3118	belongs to the thioredoxin family
NFG60_05745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NFG60_05750	COG1473	amidohydrolase
NFG60_05755	COG0784	Response regulator, receiver
NFG60_05755	COG2205	protein histidine kinase activity
NFG60_05760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NFG60_05765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NFG60_05770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NFG60_05785	COG0783	Belongs to the Dps family
NFG60_05790	COG2133	pyrroloquinoline quinone binding
NFG60_05795	COG0823	Involved in the tonB-independent uptake of proteins
NFG60_05795	COG1506	peptidase
NFG60_05795	COG4946	Tricorn protease homolog
NFG60_05805	COG3118	belongs to the thioredoxin family
NFG60_05820	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NFG60_05830	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_05855	COG1757	Na H antiporter
NFG60_05870	COG3876	Protein conserved in bacteria
NFG60_05875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NFG60_05895	COG0346	lactoylglutathione lyase activity
NFG60_05930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NFG60_05940	COG2824	Alkylphosphonate utilization operon protein PhnA
NFG60_05945	COG0454	-acetyltransferase
NFG60_05955	COG1742	UPF0060 membrane protein
NFG60_06045	COG0183	Belongs to the thiolase family
NFG60_06050	COG1024	Enoyl-CoA hydratase
NFG60_06050	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFG60_06055	COG0739	heme binding
NFG60_06055	COG0741	lytic transglycosylase activity
NFG60_06055	COG1196	nuclear chromosome segregation
NFG60_06060	COG0006	proline dipeptidase activity
NFG60_06070	COG0142	geranyltranstransferase activity
NFG60_06115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NFG60_06120	COG4942	peptidase
NFG60_06120	COG1388	LysM domain
NFG60_06125	COG1238	metal cluster binding
NFG60_06135	COG0585	pseudouridine synthase activity
NFG60_06140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NFG60_06150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NFG60_06160	COG0840	transmembrane signaling receptor activity
NFG60_06165	COG1522	sequence-specific DNA binding
NFG60_06175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NFG60_06175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NFG60_06175	COG0506	proline dehydrogenase activity
NFG60_06190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_06225	COG0494	nUDIX hydrolase
NFG60_06230	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NFG60_06235	COG0730	response to heat
NFG60_06240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NFG60_06245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NFG60_06255	COG3706	GGDEF domain
NFG60_06260	COG3437	response regulator, receiver
NFG60_06260	COG4999	Histidine kinase
NFG60_06260	COG3850	Histidine kinase
NFG60_06260	COG2205	protein histidine kinase activity
NFG60_06265	COG2211	Major facilitator Superfamily
NFG60_06285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NFG60_06300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NFG60_06305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFG60_06320	COG1648	precorrin-2 dehydrogenase activity
NFG60_06320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NFG60_06325	COG0513	Belongs to the DEAD box helicase family
NFG60_06345	COG1538	Outer membrane efflux protein
NFG60_06350	COG0494	nUDIX hydrolase
NFG60_06360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NFG60_06365	COG3150	esterase
NFG60_06380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NFG60_06400	COG1509	lysine 2,3-aminomutase activity
NFG60_06405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NFG60_06440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NFG60_06455	COG0271	Belongs to the BolA IbaG family
NFG60_06470	COG3707	response regulator
NFG60_06480	COG0659	secondary active sulfate transmembrane transporter activity
NFG60_06485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NFG60_06490	COG2146	nitrite reductase [NAD(P)H] activity
NFG60_06495	COG0243	molybdopterin cofactor binding
NFG60_06500	COG1648	precorrin-2 dehydrogenase activity
NFG60_06500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NFG60_06510	COG0737	Belongs to the 5'-nucleotidase family
NFG60_06515	COG5001	Diguanylate cyclase
NFG60_06515	COG4251	negative regulation of phosphorylation
NFG60_06515	COG2203	Gaf domain
NFG60_06515	COG3706	GGDEF domain
NFG60_06525	COG1116	anion transmembrane transporter activity
NFG60_06525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NFG60_06535	COG1116	anion transmembrane transporter activity
NFG60_06550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NFG60_06555	COG4206	TonB-dependent receptor
NFG60_06560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NFG60_06565	COG0348	domain, Protein
NFG60_06580	COG1960	acyl-CoA dehydrogenase activity
NFG60_06585	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_06595	COG4948	Mandelate Racemase Muconate Lactonizing
NFG60_06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_06615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_06635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NFG60_06640	COG0358	DNA primase activity
NFG60_06665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NFG60_06670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NFG60_06685	COG0537	adenosine 5'-monophosphoramidase activity
NFG60_06700	COG3135	benzoate transporter
NFG60_06705	COG1396	sequence-specific DNA binding
NFG60_06710	COG2974	May be involved in recombination
NFG60_06715	COG4191	Histidine kinase
NFG60_06715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_06720	COG0745	RESPONSE REGULATOR receiver
NFG60_06725	COG5002	protein histidine kinase activity
NFG60_06750	COG0811	peptide transport
NFG60_06755	COG0811	peptide transport
NFG60_06760	COG0848	biopolymer transport protein
NFG60_06765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NFG60_06775	COG3437	response regulator, receiver
NFG60_06795	COG2133	pyrroloquinoline quinone binding
NFG60_06800	COG1049	propionate catabolic process, 2-methylcitrate cycle
NFG60_06835	COG0527	aspartate kinase activity
NFG60_06845	COG0840	transmembrane signaling receptor activity
NFG60_06850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NFG60_06855	COG2967	ApaG domain
NFG60_06865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NFG60_06870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NFG60_06875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NFG60_06880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NFG60_06890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NFG60_06895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NFG60_06910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NFG60_06925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NFG60_06930	COG3956	TIGRFAM MazG family protein
NFG60_06955	COG4771	TonB-dependent receptor
NFG60_06975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NFG60_06980	COG1595	DNA-templated transcription, initiation
NFG60_07000	COG1473	amidohydrolase
NFG60_07005	COG0723	plastoquinol--plastocyanin reductase activity
NFG60_07010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NFG60_07015	COG2857	Cytochrome c1
NFG60_07020	COG0625	glutathione transferase activity
NFG60_07025	COG2969	positive regulation of protein catabolic process
NFG60_07040	COG0745	RESPONSE REGULATOR receiver
NFG60_07045	COG2239	Acts as a magnesium transporter
NFG60_07050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NFG60_07070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NFG60_07075	COG1137	ATPase activity
NFG60_07080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NFG60_07090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NFG60_07105	COG1127	ABC transporter
NFG60_07110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NFG60_07115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NFG60_07120	COG2854	intermembrane phospholipid transfer
NFG60_07130	COG5007	Belongs to the BolA IbaG family
NFG60_07140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFG60_07145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NFG60_07155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NFG60_07190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFG60_07205	COG4771	TonB-dependent receptor
NFG60_07210	COG0697	spore germination
NFG60_07220	COG2205	protein histidine kinase activity
NFG60_07220	COG0784	Response regulator, receiver
NFG60_07245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NFG60_07255	COG0126	phosphoglycerate kinase activity
NFG60_07260	COG3588	fructose-bisphosphate aldolase
NFG60_07280	COG1538	Outer membrane efflux protein
NFG60_07290	COG1506	peptidase
NFG60_07290	COG0823	Involved in the tonB-independent uptake of proteins
NFG60_07290	COG4946	Tricorn protease homolog
NFG60_07300	COG0248	Ppx GppA phosphatase
NFG60_07305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NFG60_07315	COG0573	inorganic phosphate transmembrane transporter activity
NFG60_07325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NFG60_07340	COG0306	phosphate transporter
NFG60_07350	COG0583	DNA-binding transcription factor activity
NFG60_07375	COG1272	protein, Hemolysin III
NFG60_07380	COG1846	Transcriptional regulator
NFG60_07385	COG1764	response to oxidative stress
NFG60_07400	COG1739	Uncharacterized protein family UPF0029
NFG60_07425	COG0583	DNA-binding transcription factor activity
NFG60_07430	COG4989	oxidoreductase activity
NFG60_07445	COG0420	3'-5' exonuclease activity
NFG60_07450	COG0419	ATPase involved in DNA repair
NFG60_07460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NFG60_07480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NFG60_07485	COG2986	histidine ammonia-lyase
NFG60_07500	COG2971	BadF BadG BcrA BcrD
NFG60_07505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NFG60_07515	COG0488	(ABC) transporter
NFG60_07545	COG0668	transmembrane transport
NFG60_07560	COG2814	Major facilitator Superfamily
NFG60_07610	COG1346	cytolysis
NFG60_07640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NFG60_07645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NFG60_07650	COG0513	Belongs to the DEAD box helicase family
NFG60_07670	COG3409	Peptidoglycan-binding domain 1 protein
NFG60_07670	COG3267	Type II secretory pathway component ExeA
NFG60_07700	COG0473	3-isopropylmalate dehydrogenase activity
NFG60_07705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NFG60_07720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NFG60_07740	COG2271	Major facilitator Superfamily
NFG60_07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFG60_07750	COG0800	Aldolase
NFG60_07755	COG2186	Transcriptional regulator
NFG60_07805	COG4555	ABC transporter
NFG60_07810	COG1668	transmembrane transport
NFG60_07825	COG4133	protoheme IX ABC transporter activity
NFG60_07830	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NFG60_07835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NFG60_07840	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NFG60_07850	COG1138	Cytochrome C-type biogenesis protein
NFG60_07870	COG2853	Lipoprotein
NFG60_07875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NFG60_07900	COG1682	transport, permease protein
NFG60_07915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NFG60_07930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NFG60_07935	COG1555	photosystem II stabilization
NFG60_07935	COG1596	polysaccharide export
NFG60_07940	COG0473	3-isopropylmalate dehydrogenase activity
NFG60_07955	COG1611	Belongs to the LOG family
NFG60_07965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NFG60_07965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NFG60_08005	COG0564	pseudouridine synthase activity
NFG60_08020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NFG60_08025	COG0024	Methionine aminopeptidase
NFG60_08030	COG0052	Belongs to the universal ribosomal protein uS2 family
NFG60_08040	COG0528	UMP kinase activity
NFG60_08050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NFG60_08055	COG0575	Belongs to the CDS family
NFG60_08065	COG0750	zinc metalloprotease
NFG60_08080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NFG60_08085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NFG60_08100	COG0587	DNA-directed DNA polymerase activity
NFG60_08105	COG0825	malonyl-CoA metabolic process
NFG60_08110	COG0037	tRNA processing
NFG60_08145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NFG60_08145	COG0047	phosphoribosylformylglycinamidine synthase activity
NFG60_08155	COG2840	Smr protein MutS2
NFG60_08170	COG3550	peptidyl-serine autophosphorylation
NFG60_08210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NFG60_08230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NFG60_08315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_08320	COG2197	response regulator
NFG60_08360	COG0835	chemotaxis
NFG60_08360	COG0784	Response regulator, receiver
NFG60_08365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NFG60_08370	COG1815	bacterial-type flagellum-dependent cell motility
NFG60_08385	COG1749	Flagellar hook protein flgE
NFG60_08390	COG4787	bacterial-type flagellum-dependent cell motility
NFG60_08410	COG1705	Flagellar rod assembly protein muramidase FlgJ
NFG60_08410	COG3951	Flagellar rod assembly protein muramidase FlgJ
NFG60_08415	COG1256	bacterial-type flagellum assembly
NFG60_08440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NFG60_08445	COG1334	flagellar protein FlaG
NFG60_08450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NFG60_08505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NFG60_08510	COG1086	Polysaccharide biosynthesis protein
NFG60_08525	COG3475	LICD family
NFG60_08530	COG2089	acid synthase
NFG60_08540	COG1083	cytidylyl-transferase
NFG60_08545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NFG60_08570	COG1677	Flagellar hook-basal body complex protein FliE
NFG60_08575	COG1766	The M ring may be actively involved in energy transduction
NFG60_08580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NFG60_08630	COG1987	bacterial-type flagellum assembly
NFG60_08650	COG2989	Protein conserved in bacteria
NFG60_08655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NFG60_08680	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NFG60_08685	COG2198	Histidine kinase
NFG60_08685	COG0643	Histidine kinase
NFG60_08685	COG0784	Response regulator, receiver
NFG60_08690	COG2201	protein-glutamate methylesterase activity
NFG60_08695	COG1192	Involved in chromosome partitioning
NFG60_08705	COG0835	chemotaxis
NFG60_08720	COG1410	methionine synthase
NFG60_08720	COG0646	methionine synthase
NFG60_08725	COG1410	methionine synthase
NFG60_08725	COG0646	methionine synthase
NFG60_08735	COG3123	guanosine phosphorylase activity
NFG60_08745	COG0583	DNA-binding transcription factor activity
NFG60_08750	COG0583	DNA-binding transcription factor activity
NFG60_08755	COG0288	reversible hydration of carbon dioxide
NFG60_08760	COG0659	secondary active sulfate transmembrane transporter activity
NFG60_08770	COG1309	transcriptional regulator
NFG60_08775	COG3590	peptidase
NFG60_08785	COG2137	regulation of response to DNA damage stimulus
NFG60_08790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NFG60_08815	COG1607	acyl-coa hydrolase
NFG60_08825	COG0511	ligase activity, forming carbon-carbon bonds
NFG60_08825	COG5016	pyruvate
NFG60_08830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NFG60_08835	COG4172	Belongs to the ABC transporter superfamily
NFG60_08845	COG4171	peptide transport system, permease
NFG60_08850	COG4168	peptide transport system, permease
NFG60_08855	COG0747	negative chemotaxis
NFG60_08860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NFG60_08865	COG1842	Phage shock protein A
NFG60_08895	COG0625	glutathione transferase activity
NFG60_08900	COG1522	sequence-specific DNA binding
NFG60_08930	COG0457	Tetratricopeptide repeat
NFG60_08970	COG0811	peptide transport
NFG60_08975	COG0811	peptide transport
NFG60_08980	COG0848	biopolymer transport protein
NFG60_08995	COG1444	tRNA N-acetyltransferase activity
NFG60_09035	COG0456	acetyltransferase
NFG60_09050	COG0583	DNA-binding transcription factor activity
NFG60_09055	COG2814	Major facilitator Superfamily
NFG60_09060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NFG60_09065	COG0656	L-ascorbic acid biosynthetic process
NFG60_09085	COG1846	Transcriptional regulator
NFG60_09095	COG3275	phosphorelay sensor kinase activity
NFG60_09100	COG1966	Carbon starvation protein
NFG60_09120	COG0457	Tetratricopeptide repeat
NFG60_09135	COG2197	response regulator
NFG60_09145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NFG60_09175	COG0583	DNA-binding transcription factor activity
NFG60_09180	COG0702	epimerase
NFG60_09200	COG1902	pentaerythritol trinitrate reductase activity
NFG60_09215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NFG60_09220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NFG60_09225	COG0564	pseudouridine synthase activity
NFG60_09235	COG0612	Peptidase, M16
NFG60_09240	COG2918	glutathione biosynthetic process
NFG60_09260	COG2840	Smr protein MutS2
NFG60_09265	COG2890	protein-(glutamine-N5) methyltransferase activity
NFG60_09280	COG2719	SpoVR family
NFG60_09285	COG2718	Belongs to the UPF0229 family
NFG60_09290	COG2766	serine protein kinase
NFG60_09295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NFG60_09300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NFG60_09305	COG4771	TonB-dependent receptor
NFG60_09330	COG0450	alkyl hydroperoxide reductase
NFG60_09335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NFG60_09345	COG0584	glycerophosphoryl diester phosphodiesterase
NFG60_09350	COG0346	lactoylglutathione lyase activity
NFG60_09355	COG4221	oxidoreductase activity
NFG60_09360	COG1278	Cold shock
NFG60_09380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NFG60_09385	COG4660	Part of a membrane complex involved in electron transport
NFG60_09390	COG4659	FMN binding
NFG60_09395	COG4658	electron transport chain
NFG60_09400	COG4656	Part of a membrane complex involved in electron transport
NFG60_09405	COG2878	Part of a membrane complex involved in electron transport
NFG60_09410	COG4657	Part of a membrane complex involved in electron transport
NFG60_09425	COG0534	Mate efflux family protein
NFG60_09430	COG0556	nucleotide-excision repair
NFG60_09445	COG0602	queuosine metabolic process
NFG60_09455	COG0367	asparagine synthase
NFG60_09475	COG0471	metal ion transport
NFG60_09475	COG3273	potassium ion transport
NFG60_09490	COG0529	Catalyzes the synthesis of activated sulfate
NFG60_09495	COG0175	sulfate reduction
NFG60_09500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_09550	COG0714	Associated with various cellular activities
NFG60_09560	COG1024	Enoyl-CoA hydratase
NFG60_09560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFG60_09580	COG1025	Belongs to the peptidase M16 family
NFG60_09585	COG2062	phosphohistidine phosphatase, SixA
NFG60_09595	COG4536	flavin adenine dinucleotide binding
NFG60_09600	COG4137	Cytochrome C assembly protein
NFG60_09605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NFG60_09650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_09655	COG1132	(ABC) transporter
NFG60_09670	COG0228	four-way junction DNA binding
NFG60_09675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NFG60_09680	COG0336	Belongs to the RNA methyltransferase TrmD family
NFG60_09685	COG0335	large ribosomal subunit rRNA binding
NFG60_09690	COG2860	membrane
NFG60_09700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NFG60_09705	COG0287	Prephenate dehydrogenase
NFG60_09705	COG1605	Chorismate mutase
NFG60_09735	COG1605	Chorismate mutase
NFG60_09735	COG0077	Prephenate dehydratase
NFG60_09740	COG0745	RESPONSE REGULATOR receiver
NFG60_09745	COG0023	Translation Initiation Factor
NFG60_09775	COG2205	protein histidine kinase activity
NFG60_09785	COG2204	response regulator
NFG60_09800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NFG60_09805	COG0494	nUDIX hydrolase
NFG60_09810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NFG60_09815	COG0632	four-way junction helicase activity
NFG60_09820	COG2255	four-way junction helicase activity
NFG60_09825	COG0824	Thioesterase
NFG60_09830	COG0811	peptide transport
NFG60_09845	COG0823	Involved in the tonB-independent uptake of proteins
NFG60_09850	COG2885	chlorophyll binding
NFG60_09855	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NFG60_09875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NFG60_09885	COG0582	viral genome integration into host DNA
NFG60_09930	COG0616	signal peptide processing
NFG60_09935	COG0582	viral genome integration into host DNA
NFG60_09950	COG4667	esterase of the alpha-beta hydrolase superfamily
NFG60_09955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NFG60_09965	COG0784	Response regulator, receiver
NFG60_09965	COG2205	protein histidine kinase activity
NFG60_09980	COG3038	cytochrome b561
NFG60_10000	COG1451	nucleotide metabolic process
NFG60_10010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_10020	COG1309	transcriptional regulator
NFG60_10025	COG4774	siderophore transport
NFG60_10045	COG3706	GGDEF domain
NFG60_10055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NFG60_10055	COG3008	intermembrane lipid transfer
NFG60_10060	COG2995	paraquat-inducible protein a
NFG60_10080	COG2207	Transcriptional regulator
NFG60_10105	COG0017	Asparaginyl-tRNA synthetase
NFG60_10120	COG0189	ligase activity
NFG60_10155	COG2226	methyltransferase
NFG60_10165	COG3340	Belongs to the peptidase S51 family
NFG60_10170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NFG60_10175	COG4139	cobalamin transport
NFG60_10185	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NFG60_10190	COG2205	protein histidine kinase activity
NFG60_10195	COG0745	RESPONSE REGULATOR receiver
NFG60_10200	COG0569	domain protein
NFG60_10205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NFG60_10220	COG5265	(ABC) transporter
NFG60_10225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NFG60_10235	COG0745	RESPONSE REGULATOR receiver
NFG60_10260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NFG60_10305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NFG60_10320	COG2755	lipolytic protein G-D-S-L family
NFG60_10325	COG4181	ATPase activity
NFG60_10330	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NFG60_10335	COG1090	epimerase
NFG60_10340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NFG60_10345	COG0628	permease
NFG60_10370	COG2350	Protein conserved in bacteria
NFG60_10375	COG0159	tryptophan synthase activity
NFG60_10385	COG0134	indole-3-glycerol-phosphate synthase activity
NFG60_10385	COG0135	phosphoribosylanthranilate isomerase activity
NFG60_10390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NFG60_10400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NFG60_10405	COG0613	PHP domain protein
NFG60_10410	COG0009	L-threonylcarbamoyladenylate synthase
NFG60_10420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NFG60_10430	COG0656	L-ascorbic acid biosynthetic process
NFG60_10435	COG0110	maltose O-acetyltransferase activity
NFG60_10450	COG2733	membrane
NFG60_10455	COG0500	methyltransferase
NFG60_10460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFG60_10465	COG0497	DNA recombination
NFG60_10470	COG0783	Belongs to the Dps family
NFG60_10475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NFG60_10485	COG1454	alcohol dehydrogenase
NFG60_10495	COG0515	serine threonine protein kinase
NFG60_10495	COG2815	serine threonine protein kinase
NFG60_10510	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_10520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NFG60_10525	COG2610	gluconate transmembrane transporter activity
NFG60_10530	COG4771	TonB-dependent receptor
NFG60_10545	COG2205	protein histidine kinase activity
NFG60_10545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_10545	COG0784	Response regulator, receiver
NFG60_10545	COG2198	Histidine kinase
NFG60_10555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NFG60_10565	COG0484	heat shock protein binding
NFG60_10570	COG3909	cytochrome
NFG60_10585	COG2199	diguanylate cyclase activity
NFG60_10585	COG2200	EAL domain
NFG60_10585	COG2202	Pas domain
NFG60_10600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NFG60_10610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NFG60_10615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NFG60_10620	COG0840	transmembrane signaling receptor activity
NFG60_10640	COG0071	Belongs to the small heat shock protein (HSP20) family
NFG60_10650	COG0280	phosphate acetyltransferase
NFG60_10650	COG0857	belongs to the CobB CobQ family
NFG60_10655	COG1228	amidohydrolase
NFG60_10660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NFG60_10665	COG4535	Mg2 and Co2 transporter CorC
NFG60_10675	COG1702	phosphate starvation-inducible protein PhoH
NFG60_10685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFG60_10725	COG1607	acyl-coa hydrolase
NFG60_10730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NFG60_10740	COG1115	amino acid carrier protein
NFG60_10790	COG0012	GTP binding
NFG60_10805	COG1064	alcohol dehydrogenase
NFG60_10815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NFG60_10825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NFG60_10830	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NFG60_10835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NFG60_10845	COG2890	protein-(glutamine-N5) methyltransferase activity
NFG60_10850	COG0784	Response regulator, receiver
NFG60_10850	COG3437	response regulator, receiver
NFG60_10860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NFG60_10870	COG0583	DNA-binding transcription factor activity
NFG60_10880	COG2363	Small membrane protein
NFG60_10895	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NFG60_10900	COG0515	serine threonine protein kinase
NFG60_10905	COG2116	formate transmembrane transporter activity
NFG60_10920	COG0714	Associated with various cellular activities
NFG60_10925	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NFG60_10930	COG0033	Phosphoglucomutase
NFG60_10935	COG0058	SHG alpha-glucan phosphorylase activity
NFG60_10945	COG2988	succinylglutamate desuccinylase activity
NFG60_10960	COG1301	dicarboxylic acid transport
NFG60_10980	COG1393	Belongs to the ArsC family
NFG60_11005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NFG60_11025	COG5001	Diguanylate cyclase
NFG60_11025	COG3300	MHYT domain
NFG60_11040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_11055	COG2249	NAD(P)H dehydrogenase (quinone) activity
NFG60_11080	COG1733	regulation of RNA biosynthetic process
NFG60_11090	COG5002	protein histidine kinase activity
NFG60_11090	COG3447	MASE1 domain protein
NFG60_11090	COG5001	Diguanylate cyclase
NFG60_11100	COG0402	S-adenosylhomocysteine deaminase activity
NFG60_11120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NFG60_11130	COG1309	transcriptional regulator
NFG60_11145	COG2252	PERMEase
NFG60_11150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFG60_11170	COG0784	Response regulator, receiver
NFG60_11170	COG2205	protein histidine kinase activity
NFG60_11185	COG2233	PERMEase
NFG60_11190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFG60_11205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NFG60_11210	COG0730	response to heat
NFG60_11220	COG0154	amidase activity
NFG60_11250	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_11255	COG3001	Fructosamine kinase
NFG60_11270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NFG60_11290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NFG60_11300	COG1596	polysaccharide export
NFG60_11305	COG0489	protein tyrosine kinase activity
NFG60_11310	COG4464	protein tyrosine phosphatase activity
NFG60_11345	COG0438	transferase activity, transferring glycosyl groups
NFG60_11385	COG0457	Tetratricopeptide repeat
NFG60_11395	COG0438	transferase activity, transferring glycosyl groups
NFG60_11415	COG1045	serine acetyltransferase
NFG60_11430	COG0072	phenylalanine-tRNA ligase activity
NFG60_11430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NFG60_11455	COG1472	Belongs to the glycosyl hydrolase 3 family
NFG60_11460	COG2096	Adenosyltransferase
NFG60_11470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NFG60_11480	COG4591	ABC-type transport system involved in lipoprotein release permease component
NFG60_11505	COG0708	Exodeoxyribonuclease III
NFG60_11540	COG2814	Major facilitator Superfamily
NFG60_11575	COG4770	biotin carboxylase activity
NFG60_11585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NFG60_11590	COG1960	acyl-CoA dehydrogenase activity
NFG60_11595	COG0789	Transcriptional regulator
NFG60_11600	COG0183	Belongs to the thiolase family
NFG60_11625	COG2925	Exonuclease
NFG60_11630	COG5002	protein histidine kinase activity
NFG60_11630	COG0784	Response regulator, receiver
NFG60_11630	COG2205	protein histidine kinase activity
NFG60_11670	COG1643	Atp-dependent helicase
NFG60_11690	COG3321	synthase
NFG60_11690	COG0604	alcohol dehydrogenase
NFG60_11695	COG0328	RNA-DNA hybrid ribonuclease activity
NFG60_11700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NFG60_11730	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NFG60_11735	COG1136	(ABC) transporter
NFG60_11740	COG4591	ABC-type transport system involved in lipoprotein release permease component
NFG60_11745	COG1301	dicarboxylic acid transport
NFG60_11755	COG3724	N-succinylarginine dihydrolase activity
NFG60_11760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NFG60_11765	COG3122	Protein conserved in bacteria
NFG60_11775	COG1609	Transcriptional regulator
NFG60_11800	COG2271	Major facilitator Superfamily
NFG60_11805	COG4948	Mandelate Racemase Muconate Lactonizing
NFG60_11840	COG3119	arylsulfatase activity
NFG60_11845	COG0746	molybdenum cofactor guanylyltransferase activity
NFG60_11850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NFG60_11855	COG0243	molybdopterin cofactor binding
NFG60_11860	COG3250	beta-galactosidase activity
NFG60_11925	COG2124	cytochrome p450
NFG60_11970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NFG60_11975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NFG60_11980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NFG60_12000	COG4771	TonB-dependent receptor
NFG60_12005	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_12020	COG1024	Enoyl-CoA hydratase
NFG60_12025	COG2030	dehydratase
NFG60_12025	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_12035	COG1024	Enoyl-CoA hydratase
NFG60_12050	COG2814	Major facilitator Superfamily
NFG60_12065	COG1960	acyl-CoA dehydrogenase activity
NFG60_12070	COG1960	acyl-CoA dehydrogenase activity
NFG60_12075	COG0183	Belongs to the thiolase family
NFG60_12080	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFG60_12080	COG1024	Enoyl-CoA hydratase
NFG60_12090	COG1858	cytochrome C peroxidase
NFG60_12105	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_12110	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_12115	COG1063	alcohol dehydrogenase
NFG60_12120	COG4948	Mandelate Racemase Muconate Lactonizing
NFG60_12130	COG3386	PFAM SMP-30 Gluconolaconase
NFG60_12135	COG2814	Major facilitator Superfamily
NFG60_12140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFG60_12150	COG2153	protein acetylation
NFG60_12165	COG5002	protein histidine kinase activity
NFG60_12175	COG1530	ribonuclease E activity
NFG60_12180	COG0564	pseudouridine synthase activity
NFG60_12185	COG0546	phosphoglycolate phosphatase activity
NFG60_12190	COG0424	maF-like protein
NFG60_12195	COG1399	metal-binding, possibly nucleic acid-binding protein
NFG60_12205	COG0416	fatty acid biosynthetic process
NFG60_12210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NFG60_12215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NFG60_12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NFG60_12230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFG60_12235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NFG60_12240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NFG60_12255	COG0084	hydrolase, TatD family'
NFG60_12260	COG0259	pyridoxamine-phosphate oxidase activity
NFG60_12265	COG0702	epimerase
NFG60_12270	COG3706	GGDEF domain
NFG60_12295	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_12300	COG0596	Alpha beta hydrolase
NFG60_12305	COG1024	Enoyl-CoA hydratase
NFG60_12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
NFG60_12310	COG0183	Belongs to the thiolase family
NFG60_12315	COG1960	acyl-CoA dehydrogenase activity
NFG60_12320	COG0596	Alpha beta hydrolase
NFG60_12335	COG2390	Transcriptional regulator
NFG60_12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NFG60_12350	COG0246	Mannitol dehydrogenase
NFG60_12375	COG0668	transmembrane transport
NFG60_12380	COG4771	TonB-dependent receptor
NFG60_12405	COG2198	Histidine kinase
NFG60_12405	COG0784	Response regulator, receiver
NFG60_12405	COG2205	protein histidine kinase activity
NFG60_12410	COG3437	response regulator, receiver
NFG60_12420	COG0195	Participates in both transcription termination and antitermination
NFG60_12435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NFG60_12455	COG1187	pseudouridine synthase activity
NFG60_12465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NFG60_12465	COG3153	acetyltransferase
NFG60_12530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_12550	COG1032	radical SAM domain protein
NFG60_12565	COG4771	TonB-dependent receptor
NFG60_12570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFG60_12580	COG4134	Bacterial extracellular solute-binding protein
NFG60_12590	COG4136	ATPase activity
NFG60_12595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NFG60_12610	COG0604	alcohol dehydrogenase
NFG60_12645	COG0583	DNA-binding transcription factor activity
NFG60_12650	COG2249	NAD(P)H dehydrogenase (quinone) activity
NFG60_12665	COG0583	DNA-binding transcription factor activity
NFG60_12690	COG1131	(ABC) transporter
NFG60_12700	COG1902	pentaerythritol trinitrate reductase activity
NFG60_12710	COG2867	negative regulation of translational initiation
NFG60_12715	COG2914	Belongs to the UPF0125 (RnfH) family
NFG60_12725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NFG60_12735	COG0457	Tetratricopeptide repeat
NFG60_12755	COG0574	Belongs to the PEP-utilizing enzyme family
NFG60_12755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NFG60_12790	COG2850	peptidyl-arginine hydroxylation
NFG60_12800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NFG60_12805	COG2915	High frequency lysogenization protein hflD homolog
NFG60_12815	COG1187	pseudouridine synthase activity
NFG60_12825	COG1278	Cold shock
NFG60_12830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NFG60_12835	COG0542	response to heat
NFG60_12840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NFG60_12845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NFG60_12850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NFG60_12855	COG0492	ferredoxin-NADP+ reductase activity
NFG60_12860	COG3092	negative regulation of chromosome organization
NFG60_12865	COG3091	SprT-like family
NFG60_12870	COG0616	signal peptide processing
NFG60_12885	COG0778	Nitroreductase
NFG60_12895	COG0252	asparaginase activity
NFG60_12910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NFG60_12920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NFG60_12925	COG0321	lipoyl(octanoyl) transferase activity
NFG60_12930	COG2921	Belongs to the UPF0250 family
NFG60_12935	COG1686	Belongs to the peptidase S11 family
NFG60_12940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NFG60_12945	COG0772	Belongs to the SEDS family
NFG60_12950	COG0768	penicillin binding
NFG60_12955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NFG60_12960	COG0799	negative regulation of ribosome biogenesis
NFG60_12970	COG1466	dna polymerase III delta subunit
NFG60_12975	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NFG60_12980	COG0495	leucyl-tRNA aminoacylation
NFG60_12990	COG1067	ATP-dependent peptidase activity
NFG60_13010	COG1534	Rna-binding protein
NFG60_13015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NFG60_13020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NFG60_13025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NFG60_13030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NFG60_13035	COG0149	triose-phosphate isomerase activity
NFG60_13040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NFG60_13070	COG1803	Methylglyoxal synthase
NFG60_13070	COG1597	lipid kinase activity
NFG60_13080	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_13085	COG0561	phosphatase activity
NFG60_13100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_13105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NFG60_13110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NFG60_13125	COG1185	polyribonucleotide nucleotidyltransferase activity
NFG60_13255	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NFG60_13260	COG1196	nuclear chromosome segregation
NFG60_13270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NFG60_13285	COG1132	(ABC) transporter
NFG60_13290	COG1663	tetraacyldisaccharide 4'-kinase activity
NFG60_13330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NFG60_13335	COG0435	Glutathione S-transferase
NFG60_13340	COG1741	Belongs to the pirin family
NFG60_13360	COG0372	Belongs to the citrate synthase family
NFG60_13370	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NFG60_13375	COG1053	succinate dehydrogenase
NFG60_13380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NFG60_13385	COG0567	Dehydrogenase, E1 component
NFG60_13390	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFG60_13445	COG4667	esterase of the alpha-beta hydrolase superfamily
NFG60_13465	COG0366	Alpha amylase catalytic
NFG60_13475	COG0366	Alpha amylase catalytic
NFG60_13475	COG1874	Beta-galactosidase
NFG60_13480	COG1609	Transcriptional regulator
NFG60_13490	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_13495	COG2267	carboxylic ester hydrolase activity
NFG60_13505	COG0616	signal peptide processing
NFG60_13520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NFG60_13525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NFG60_13530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NFG60_13535	COG0386	Belongs to the glutathione peroxidase family
NFG60_13540	COG2084	Dehydrogenase
NFG60_13550	COG1960	acyl-CoA dehydrogenase activity
NFG60_13555	COG1024	Enoyl-CoA hydratase
NFG60_13560	COG2226	methyltransferase
NFG60_13565	COG3083	sulfuric ester hydrolase activity
NFG60_13570	COG3082	Protein of unknown function (DUF1414)
NFG60_13575	COG3081	Nucleoid-associated protein
NFG60_13585	COG0739	heme binding
NFG60_13585	COG0741	lytic transglycosylase activity
NFG60_13585	COG1196	nuclear chromosome segregation
NFG60_13605	COG3275	phosphorelay sensor kinase activity
NFG60_13610	COG3279	Response regulator of the LytR AlgR family
NFG60_13615	COG0205	6-phosphofructokinase activity
NFG60_13630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_13630	COG2205	protein histidine kinase activity
NFG60_13640	COG1054	Belongs to the UPF0176 family
NFG60_13660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFG60_13670	COG0513	Belongs to the DEAD box helicase family
NFG60_13680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NFG60_13685	COG0583	DNA-binding transcription factor activity
NFG60_13705	COG1760	l-serine dehydratase
NFG60_13725	COG1322	Protein conserved in bacteria
NFG60_13745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NFG60_13750	COG0022	dehydrogenase e1 component
NFG60_13760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NFG60_13765	COG0515	serine threonine protein kinase
NFG60_13770	COG1946	Acyl-CoA thioesterase
NFG60_13780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NFG60_13790	COG1956	GAF domain-containing protein
NFG60_13805	COG0793	Belongs to the peptidase S41A family
NFG60_13810	COG0733	neurotransmitter:sodium symporter activity
NFG60_13815	COG1757	Na H antiporter
NFG60_13820	COG0308	aminopeptidase N
NFG60_13855	COG0167	dihydroorotate dehydrogenase activity
NFG60_13870	COG0488	(ABC) transporter
NFG60_13880	COG3130	regulation of translation
NFG60_13885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NFG60_13895	COG0415	Belongs to the DNA photolyase family
NFG60_13900	COG0415	Belongs to the DNA photolyase family
NFG60_13905	COG0415	Belongs to the DNA photolyase family
NFG60_13910	COG3046	protein related to deoxyribodipyrimidine photolyase
NFG60_13935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NFG60_13940	COG0589	response to stress
NFG60_13950	COG0069	glutamate synthase activity
NFG60_13965	COG2193	ferroxidase activity
NFG60_13975	COG3278	Belongs to the heme-copper respiratory oxidase family
NFG60_13990	COG2010	Cytochrome c
NFG60_14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NFG60_14020	COG0589	response to stress
NFG60_14025	COG0037	tRNA processing
NFG60_14030	COG1752	Esterase of the alpha-beta hydrolase superfamily
NFG60_14050	COG1280	lysine exporter protein (LysE YggA)
NFG60_14060	COG2897	thiosulfate sulfurtransferase activity
NFG60_14065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NFG60_14070	COG3148	PFAM DTW domain containing protein
NFG60_14095	COG0322	excinuclease ABC activity
NFG60_14100	COG2197	response regulator
NFG60_14105	COG1741	Belongs to the pirin family
NFG60_14115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NFG60_14135	COG3384	dioxygenase
NFG60_14140	COG2259	Doxx family
NFG60_14145	COG0583	DNA-binding transcription factor activity
NFG60_14160	COG0670	Belongs to the BI1 family
NFG60_14165	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NFG60_14180	COG2920	part of a sulfur-relay system
NFG60_14205	COG4771	TonB-dependent receptor
NFG60_14220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NFG60_14225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NFG60_14230	COG0531	amino acid
NFG60_14230	COG1674	ftsk spoiiie
NFG60_14240	COG0686	Belongs to the AlaDH PNT family
NFG60_14245	COG0284	orotidine-5'-phosphate decarboxylase activity
NFG60_14250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NFG60_14265	COG0776	regulation of translation
NFG60_14270	COG0539	negative regulation of cytoplasmic translation
NFG60_14275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NFG60_14280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NFG60_14285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NFG60_14295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NFG60_14300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NFG60_14305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NFG60_14310	COG0633	Ferredoxin
NFG60_14315	COG4221	oxidoreductase activity
NFG60_14355	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NFG60_14360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NFG60_14370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NFG60_14380	COG4783	chaperone-mediated protein folding
NFG60_14385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NFG60_14390	COG1393	Belongs to the ArsC family
NFG60_14425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NFG60_14435	COG1960	acyl-CoA dehydrogenase activity
NFG60_14460	COG0572	uridine kinase
NFG60_14465	COG3769	mannosylglycerate metabolic process
NFG60_14470	COG1215	transferase activity, transferring glycosyl groups
NFG60_14485	COG0303	'Molybdopterin
NFG60_14490	COG0534	Mate efflux family protein
NFG60_14505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NFG60_14510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NFG60_14555	COG3011	Protein conserved in bacteria
NFG60_14605	COG0405	Gamma-glutamyltransferase
NFG60_14610	COG1024	Enoyl-CoA hydratase
NFG60_14670	COG1671	Belongs to the UPF0178 family
NFG60_14675	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_14680	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_14685	COG1960	acyl-CoA dehydrogenase activity
NFG60_14690	COG0662	Cupin 2, conserved barrel domain protein
NFG60_14690	COG2207	Transcriptional regulator
NFG60_14705	COG1505	serine-type exopeptidase activity
NFG60_14750	COG0596	Alpha beta hydrolase
NFG60_14760	COG0716	FMN binding
NFG60_14770	COG0735	belongs to the Fur family
NFG60_14780	COG1984	allophanate hydrolase subunit 2
NFG60_14785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NFG60_14790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NFG60_14795	COG2996	Protein conserved in bacteria
NFG60_14800	COG1765	OsmC-like protein
NFG60_14805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_14815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_14830	COG0436	Aminotransferase
NFG60_14835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NFG60_14840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NFG60_14865	COG0653	protein targeting
NFG60_14870	COG0366	Alpha amylase catalytic
NFG60_14875	COG0604	alcohol dehydrogenase
NFG60_14885	COG1960	acyl-CoA dehydrogenase activity
NFG60_14895	COG4771	TonB-dependent receptor
NFG60_14920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NFG60_14940	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NFG60_14945	COG0315	cyclic pyranopterin monophosphate synthase activity
NFG60_14950	COG0521	Mo-molybdopterin cofactor biosynthetic process
NFG60_14955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NFG60_14965	COG2423	ornithine cyclodeaminase activity
NFG60_14970	COG0436	Aminotransferase
NFG60_14975	COG1522	sequence-specific DNA binding
NFG60_14990	COG0826	peptidase U32
NFG60_14995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NFG60_15000	COG0436	Aminotransferase
NFG60_15005	COG3268	Saccharopine dehydrogenase
NFG60_15010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFG60_15030	COG4771	TonB-dependent receptor
NFG60_15080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFG60_15090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NFG60_15095	COG1074	ATP-dependent DNA helicase activity
NFG60_15100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NFG60_15110	COG1022	Amp-dependent synthetase and ligase
NFG60_15135	COG0583	DNA-binding transcription factor activity
NFG60_15155	COG0640	Transcriptional regulator
NFG60_15175	COG2204	response regulator
NFG60_15185	COG4251	negative regulation of phosphorylation
NFG60_15190	COG0784	Response regulator, receiver
NFG60_15195	COG2205	protein histidine kinase activity
NFG60_15195	COG0784	Response regulator, receiver
NFG60_15250	COG3139	Protein of unknown function (DUF1315)
NFG60_15260	COG1115	amino acid carrier protein
NFG60_15265	COG2866	Carboxypeptidase
NFG60_15285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NFG60_15295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NFG60_15300	COG1640	4-alpha-glucanotransferase
NFG60_15310	COG0676	glucose-6-phosphate 1-epimerase activity
NFG60_15315	COG0800	Aldolase
NFG60_15325	COG0129	dihydroxy-acid dehydratase activity
NFG60_15335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NFG60_15340	COG1737	Transcriptional regulator
NFG60_15345	COG0469	pyruvate kinase activity
NFG60_15370	COG2823	Periplasmic or secreted lipoprotein
NFG60_15405	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_15410	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NFG60_15420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NFG60_15435	COG2721	sulfolactate sulfo-lyase activity
NFG60_15440	COG1904	glucuronate isomerase
NFG60_15445	COG0246	Mannitol dehydrogenase
NFG60_15450	COG0800	Aldolase
NFG60_15455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFG60_15460	COG2755	lipolytic protein G-D-S-L family
NFG60_15470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NFG60_15480	COG4677	pectinesterase activity
NFG60_15500	COG2356	endonuclease I
NFG60_15525	COG0583	DNA-binding transcription factor activity
NFG60_15535	COG1979	alcohol dehydrogenase
NFG60_15540	COG1902	pentaerythritol trinitrate reductase activity
NFG60_15545	COG1716	ATPase activity
NFG60_15545	COG5001	Diguanylate cyclase
NFG60_15555	COG0753	catalase activity
NFG60_15560	COG3437	response regulator, receiver
NFG60_15560	COG0784	Response regulator, receiver
NFG60_15565	COG4191	Histidine kinase
NFG60_15565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_15655	COG0471	metal ion transport
NFG60_15670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NFG60_15670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NFG60_15675	COG0668	transmembrane transport
NFG60_15680	COG2226	methyltransferase
NFG60_15685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NFG60_15690	COG0741	lytic transglycosylase activity
NFG60_15690	COG1388	LysM domain
NFG60_15710	COG3138	arginine N-succinyltransferase
NFG60_15715	COG0215	cysteine-tRNA ligase activity
NFG60_15720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NFG60_15725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NFG60_15735	COG2268	Band 7 protein
NFG60_15740	COG0583	DNA-binding transcription factor activity
NFG60_15745	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_15760	COG1733	regulation of RNA biosynthetic process
NFG60_15765	COG0604	alcohol dehydrogenase
NFG60_15770	COG0861	Integral membrane protein TerC family
NFG60_15775	COG1063	alcohol dehydrogenase
NFG60_15780	COG0583	DNA-binding transcription factor activity
NFG60_15820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NFG60_15825	COG1286	toxin biosynthetic process
NFG60_15830	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NFG60_15835	COG0285	dihydrofolate synthase activity
NFG60_15860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFG60_15885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NFG60_15890	COG0318	PFAM AMP-dependent synthetase and ligase
NFG60_15900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFG60_15900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NFG60_15945	COG0789	Transcriptional regulator
NFG60_15955	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_15960	COG1119	ATPase activity
NFG60_15970	COG0523	cobalamin synthesis protein
NFG60_15980	COG1335	isochorismatase
NFG60_15990	COG2031	fatty acid transporter
NFG60_15995	COG2205	protein histidine kinase activity
NFG60_15995	COG0784	Response regulator, receiver
NFG60_15995	COG5002	protein histidine kinase activity
NFG60_16010	COG0612	Peptidase, M16
NFG60_16025	COG3101	peptidyl-lysine hydroxylation
NFG60_16065	COG2050	protein possibly involved in aromatic compounds catabolism
NFG60_16070	COG2207	Transcriptional regulator
NFG60_16070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NFG60_16080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NFG60_16090	COG3119	arylsulfatase activity
NFG60_16100	COG2855	membrane
NFG60_16105	COG0583	DNA-binding transcription factor activity
NFG60_16140	COG4948	Mandelate Racemase Muconate Lactonizing
NFG60_16155	COG3119	arylsulfatase activity
NFG60_16160	COG3119	arylsulfatase activity
NFG60_16165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NFG60_16170	COG0800	Aldolase
NFG60_16180	COG0477	Major facilitator Superfamily
NFG60_16185	COG1609	Transcriptional regulator
NFG60_16205	COG0446	pyridine nucleotide-disulphide oxidoreductase
NFG60_16205	COG1902	pentaerythritol trinitrate reductase activity
NFG60_16230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NFG60_16240	COG4399	Belongs to the UPF0754 family
NFG60_16270	COG2186	Transcriptional regulator
NFG60_16280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NFG60_16285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NFG60_16290	COG2983	Belongs to the UPF0260 family
NFG60_16295	COG0179	Fumarylacetoacetate (FAA) hydrolase
NFG60_16310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NFG60_16315	COG0318	PFAM AMP-dependent synthetase and ligase
NFG60_16320	COG2267	carboxylic ester hydrolase activity
NFG60_16335	COG1214	PFAM Peptidase M22, glycoprotease
NFG60_16340	COG1199	ATP-dependent helicase activity
NFG60_16430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NFG60_16435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NFG60_16440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFG60_16445	COG0131	Imidazoleglycerol-phosphate dehydratase
NFG60_16445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NFG60_16450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NFG60_16480	COG2116	formate transmembrane transporter activity
NFG60_16485	COG0612	Peptidase, M16
NFG60_16510	COG0326	Molecular chaperone. Has ATPase activity
NFG60_16515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NFG60_16540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NFG60_16545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NFG60_16555	COG3220	belongs to the UPF0276 family
NFG60_16605	COG1183	phosphatidylcholine synthase activity
NFG60_16625	COG0277	FAD linked oxidase domain protein
NFG60_16630	COG1620	l-lactate permease
NFG60_16650	COG0542	response to heat
NFG60_16675	COG1595	DNA-templated transcription, initiation
NFG60_16690	COG4221	oxidoreductase activity
NFG60_16705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NFG60_16715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NFG60_16725	COG0142	geranyltranstransferase activity
NFG60_16740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NFG60_16745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NFG60_16755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NFG60_16770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NFG60_16770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NFG60_16785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NFG60_16790	COG0488	(ABC) transporter
NFG60_16800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NFG60_16810	COG0560	Phosphoserine phosphatase
NFG60_16820	COG0084	hydrolase, TatD family'
NFG60_16835	COG0571	ribonuclease III activity
NFG60_16865	COG1595	DNA-templated transcription, initiation
NFG60_16870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NFG60_16885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NFG60_16965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NFG60_16970	COG1047	Peptidyl-prolyl cis-trans
NFG60_16980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NFG60_16985	COG0196	riboflavin kinase activity
NFG60_16990	COG0728	peptidoglycan biosynthetic process
NFG60_16995	COG0268	Binds directly to 16S ribosomal RNA
NFG60_17010	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_17015	COG0385	Bile acid
NFG60_17040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NFG60_17045	COG0776	regulation of translation
NFG60_17050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NFG60_17055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NFG60_17060	COG0740	serine-type endopeptidase activity
NFG60_17065	COG0544	peptidyl-prolyl cis-trans isomerase activity
NFG60_17120	COG1720	tRNA m6t6A37 methyltransferase activity
NFG60_17130	COG1234	tRNA 3'-trailer cleavage
NFG60_17140	COG0123	including yeast histone deacetylase and acetoin utilization protein
NFG60_17155	COG0516	GMP reductase activity
NFG60_17155	COG0517	IMP dehydrogenase activity
NFG60_17160	COG1570	exodeoxyribonuclease VII activity
NFG60_17180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NFG60_17185	COG2976	Protein conserved in bacteria
NFG60_17205	COG3063	Type IV pilus biogenesis stability protein PilW
NFG60_17210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NFG60_17220	COG2166	iron-sulfur cluster assembly
NFG60_17235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NFG60_17240	COG0719	Fe-S assembly protein
NFG60_17245	COG0396	ATPase activity
NFG60_17250	COG0719	Fe-S assembly protein
NFG60_17255	COG1104	cysteine desulfurase activity
NFG60_17260	COG1959	2 iron, 2 sulfur cluster binding
NFG60_17280	COG1595	DNA-templated transcription, initiation
NFG60_17285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFG60_17295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_17305	COG1045	serine acetyltransferase
NFG60_17310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NFG60_17315	COG0483	inositol monophosphate 1-phosphatase activity
NFG60_17325	COG3279	Response regulator of the LytR AlgR family
NFG60_17330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFG60_17335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NFG60_17340	COG1862	Preprotein translocase
NFG60_17345	COG0343	queuine tRNA-ribosyltransferase activity
NFG60_17365	COG1842	Phage shock protein A
NFG60_17370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NFG60_17390	COG0754	glutathionylspermidine amidase activity
NFG60_17420	COG2066	Belongs to the glutaminase family
NFG60_17425	COG1785	Belongs to the alkaline phosphatase family
NFG60_17430	COG0745	RESPONSE REGULATOR receiver
NFG60_17535	COG0438	transferase activity, transferring glycosyl groups
NFG60_17550	COG0367	asparagine synthase
NFG60_17565	COG2327	Polysaccharide pyruvyl transferase
NFG60_17615	COG2244	polysaccharide biosynthetic process
NFG60_17620	COG0438	transferase activity, transferring glycosyl groups
NFG60_17655	COG0489	protein tyrosine kinase activity
NFG60_17665	COG3267	Type II secretory pathway component ExeA
NFG60_17665	COG3409	Peptidoglycan-binding domain 1 protein
NFG60_17670	COG2827	Endonuclease containing a URI domain
NFG60_17690	COG1560	Kdo2-lipid A biosynthetic process
NFG60_17705	COG1960	acyl-CoA dehydrogenase activity
NFG60_17725	COG1435	thymidine kinase activity
NFG60_17740	COG1609	Transcriptional regulator
NFG60_17745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NFG60_17765	COG1082	Xylose isomerase domain protein TIM barrel
NFG60_17775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NFG60_17790	COG1982	Orn Lys Arg decarboxylase major
NFG60_17820	COG1012	belongs to the aldehyde dehydrogenase family
NFG60_17840	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NFG60_17845	COG0789	Transcriptional regulator
NFG60_17865	COG3706	GGDEF domain
NFG60_17880	COG1960	acyl-CoA dehydrogenase activity
NFG60_17975	COG0601	transmembrane transport
NFG60_17980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NFG60_17985	COG4172	Belongs to the ABC transporter superfamily
NFG60_17990	COG1028	Short-chain dehydrogenase reductase Sdr
NFG60_18000	COG0693	protein deglycase activity
NFG60_18005	COG1295	ribonuclease BN
NFG60_18015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NFG60_18025	COG3279	Response regulator of the LytR AlgR family
NFG60_18030	COG2207	Transcriptional regulator
NFG60_18035	COG1073	alpha beta
NFG60_18040	COG1073	alpha beta
NFG60_18075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NFG60_18125	COG0339	signal peptide processing
NFG60_18180	COG0514	ATP-dependent DNA helicase (RecQ)
NFG60_18205	COG4251	negative regulation of phosphorylation
NFG60_18210	COG2133	pyrroloquinoline quinone binding
NFG60_18265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NFG60_18265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NFG60_18280	COG0738	Major facilitator superfamily
NFG60_18285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NFG60_18295	COG2971	BadF BadG BcrA BcrD
NFG60_18320	COG0583	DNA-binding transcription factor activity
NFG60_18350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFG60_18355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NFG60_18360	COG0006	proline dipeptidase activity
NFG60_18375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NFG60_18390	COG0784	Response regulator, receiver
NFG60_18390	COG2198	Histidine kinase
NFG60_18390	COG2205	protein histidine kinase activity
NFG60_18395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NFG60_18400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NFG60_18405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFG60_18425	COG3313	Fe-S protein
NFG60_18450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFG60_18455	COG0508	dehydrogenase complex catalyzes the overall conversion of
NFG60_18460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NFG60_18480	COG3577	Aspartyl protease
NFG60_18485	COG0157	Belongs to the NadC ModD family
NFG60_18490	COG4969	Belongs to the N-Me-Phe pilin family
NFG60_18495	COG1459	type II secretion system
NFG60_18500	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NFG60_18505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NFG60_18505	COG0237	dephospho-CoA kinase activity
NFG60_18510	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NFG60_18515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NFG60_18520	COG3608	succinylglutamate desuccinylase aspartoacylase
NFG60_18525	COG0840	transmembrane signaling receptor activity
NFG60_18530	COG4566	intracellular signal transduction
NFG60_18545	COG0643	Histidine kinase
NFG60_18545	COG2198	Histidine kinase
NFG60_18555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NFG60_18565	COG2201	protein-glutamate methylesterase activity
NFG60_18570	COG0835	chemotaxis
NFG60_18575	COG0840	transmembrane signaling receptor activity
NFG60_18580	COG0494	nUDIX hydrolase
NFG60_18590	COG0739	heme binding
NFG60_18595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NFG60_18600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NFG60_18605	COG0849	cell division
NFG60_18610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NFG60_18615	COG1181	Belongs to the D-alanine--D-alanine ligase family
NFG60_18630	COG0772	Belongs to the SEDS family
NFG60_18635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NFG60_18645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NFG60_18650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NFG60_18655	COG0768	penicillin binding
NFG60_18660	COG3116	cell division
NFG60_18670	COG2001	Belongs to the MraZ family
NFG60_18690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NFG60_18695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_18715	COG0678	peroxiredoxin activity
NFG60_18715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NFG60_18740	COG2204	response regulator
NFG60_18765	COG0668	transmembrane transport
NFG60_18770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NFG60_18775	COG0189	ligase activity
NFG60_18780	COG1678	Uncharacterized ACR, COG1678
NFG60_18785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NFG60_18810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NFG60_18815	COG0762	integral membrane protein
NFG60_18825	COG1902	pentaerythritol trinitrate reductase activity
NFG60_18825	COG0446	pyridine nucleotide-disulphide oxidoreductase
NFG60_18855	COG1764	response to oxidative stress
NFG60_18860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NFG60_18870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NFG60_18875	COG1396	sequence-specific DNA binding
NFG60_18880	COG2814	Major facilitator Superfamily
NFG60_18885	COG0724	RNA recognition motif
NFG60_18910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NFG60_18915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NFG60_18920	COG0083	homoserine kinase activity
NFG60_18930	COG0583	DNA-binding transcription factor activity
NFG60_18945	COG2197	response regulator
NFG60_18950	COG4585	Histidine kinase
NFG60_18965	COG0640	Transcriptional regulator
NFG60_18975	COG0431	NADPH-dependent FMN reductase
NFG60_18980	COG0798	PFAM Bile acid sodium symporter
NFG60_18985	COG2201	protein-glutamate methylesterase activity
NFG60_18990	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NFG60_19000	COG0642	Histidine kinase
NFG60_19020	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NFG60_19050	COG1748	Saccharopine dehydrogenase
NFG60_19070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NFG60_19075	COG3107	peptidoglycan biosynthetic process
NFG60_19095	COG2823	Periplasmic or secreted lipoprotein
NFG60_19115	COG4585	Histidine kinase
NFG60_19120	COG2197	response regulator
NFG60_19135	COG4771	TonB-dependent receptor
NFG60_19145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NFG60_19150	COG0372	Belongs to the citrate synthase family
NFG60_19155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NFG60_19160	COG2828	Protein conserved in bacteria
NFG60_19165	COG2203	Gaf domain
NFG60_19165	COG2199	diguanylate cyclase activity
NFG60_19185	COG5002	protein histidine kinase activity
NFG60_19185	COG2198	Histidine kinase
NFG60_19185	COG0784	Response regulator, receiver
NFG60_19195	COG0067	glutamate synthase
NFG60_19195	COG0070	glutamate synthase
NFG60_19195	COG0069	glutamate synthase activity
NFG60_19200	COG0493	'glutamate synthase
NFG60_19215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NFG60_19220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NFG60_19225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NFG60_19230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NFG60_19245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NFG60_19250	COG5507	3-demethylubiquinone-9 3-methyltransferase
NFG60_19270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NFG60_19275	COG1196	nuclear chromosome segregation
NFG60_19275	COG0741	lytic transglycosylase activity
NFG60_19275	COG0739	heme binding
NFG60_19280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NFG60_19290	COG0738	Major facilitator superfamily
NFG60_19300	COG1902	pentaerythritol trinitrate reductase activity
NFG60_19315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NFG60_19320	COG0625	glutathione transferase activity
NFG60_19340	COG2894	cell division
NFG60_19345	COG0850	regulation of cytokinetic process
NFG60_19380	COG1981	membrane
NFG60_19395	COG1914	H( )-stimulated, divalent metal cation uptake system
NFG60_19410	COG0745	RESPONSE REGULATOR receiver
NFG60_19415	COG1217	gtp-binding protein TYPA
NFG60_19420	COG0174	glutamine synthetase
NFG60_19430	COG3852	Histidine kinase
NFG60_19435	COG2204	response regulator
NFG60_19440	COG3437	response regulator, receiver
NFG60_19485	COG0525	valine-tRNA ligase activity
NFG60_19490	COG2927	DNA polymerase III (CHI subunit)
NFG60_19495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NFG60_19500	COG0795	lipopolysaccharide-transporting ATPase activity
NFG60_19505	COG0795	lipopolysaccharide-transporting ATPase activity
NFG60_19845	COG0673	inositol 2-dehydrogenase activity
NFG60_19850	COG2198	Histidine kinase
NFG60_19850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NFG60_19850	COG0784	Response regulator, receiver
NFG60_19850	COG2205	protein histidine kinase activity
NFG60_19855	COG0628	permease
NFG60_19875	COG1858	cytochrome C peroxidase
NFG60_19880	COG4771	TonB-dependent receptor
NFG60_19910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NFG60_19940	COG4771	TonB-dependent receptor
NFG60_19950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NFG60_19990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NFG60_20010	COG1609	Transcriptional regulator
NFG60_20015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NFG60_20035	COG4447	cellulose binding
NFG60_20065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NFG60_20075	COG1064	alcohol dehydrogenase
NFG60_20080	COG0667	Aldo Keto reductase
NFG60_20095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NFG60_20105	COG0679	Auxin Efflux Carrier
NFG60_20110	COG2267	carboxylic ester hydrolase activity
NFG60_20140	COG1131	(ABC) transporter
NFG60_20150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NFG60_20205	COG2205	protein histidine kinase activity
NFG60_20215	COG3901	Regulator of nitric oxide reductase transcription
NFG60_20215	COG0348	domain, Protein
NFG60_20225	COG2197	response regulator
NFG60_20265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NFG60_20280	COG4771	TonB-dependent receptor
NFG60_20290	COG0583	DNA-binding transcription factor activity
NFG60_20295	COG1304	FMN binding
NFG60_20300	COG0277	FAD linked oxidase domain protein
NFG60_20310	COG1462	curli production assembly transport component CsgG
NFG60_20340	COG2197	response regulator
NFG60_20355	COG0513	Belongs to the DEAD box helicase family
NFG60_20360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NFG60_20360	COG3264	Mechanosensitive ion channel
NFG60_20380	COG2199	diguanylate cyclase activity
NFG60_20380	COG2200	EAL domain
NFG60_20380	COG2202	Pas domain
NFG60_20405	COG0730	response to heat
NFG60_20410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NFG60_20425	COG4191	Histidine kinase
NFG60_20435	COG0417	DNA replication proofreading
NFG60_20445	COG0318	PFAM AMP-dependent synthetase and ligase
NFG60_20500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NFG60_20510	COG1573	uracil-dna glycosylase
NFG60_20515	COG3300	MHYT domain
NFG60_20515	COG5001	Diguanylate cyclase
NFG60_20535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NFG60_20555	COG1983	PspC domain protein
NFG60_20560	COG1842	Phage shock protein A
NFG60_20570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NFG60_20585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NFG60_20595	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NFG60_20600	COG0204	Acyl-transferase
NFG60_20605	COG0204	Acyl-transferase
NFG60_20610	COG0668	transmembrane transport
NFG60_20625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NFG60_20630	COG0733	neurotransmitter:sodium symporter activity
NFG60_20645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NFG60_20660	COG0716	FMN binding
NFG60_20670	COG0848	biopolymer transport protein
NFG60_20680	COG0457	Tetratricopeptide repeat
NFG60_20685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NFG60_20710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NFG60_20715	COG0702	epimerase
NFG60_20730	COG5001	Diguanylate cyclase
NFG60_20730	COG5002	protein histidine kinase activity
NFG60_20740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NFG60_20750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NFG60_20760	COG0583	DNA-binding transcription factor activity
NFG60_20765	COG0121	glutamine amidotransferase
NFG60_20780	COG4682	membrane
NFG60_20845	COG1396	sequence-specific DNA binding
NFG60_20850	COG3550	peptidyl-serine autophosphorylation
NFG60_20910	COG1192	Involved in chromosome partitioning
NFG60_20965	COG3209	COG3209 Rhs family protein
NFG60_20975	COG4584	PFAM Integrase catalytic
NFG60_20980	COG1484	DNA-dependent DNA replication
NFG60_20990	COG4974	Belongs to the 'phage' integrase family
NFG60_21000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NFG60_21045	COG2201	protein-glutamate methylesterase activity
NFG60_21085	COG3209	COG3209 Rhs family protein