locus-tag	class	description
I633_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I633_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I633_00020	COG0187	DNA topoisomerase II activity
I633_00040	COG2818	Glycosylase
I633_00050	COG3078	GTPase activator activity
I633_00085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I633_00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I633_00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I633_00115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I633_00130	COG0758	DNA mediated transformation
I633_00145	COG0009	L-threonylcarbamoyladenylate synthase
I633_00150	COG0408	coproporphyrinogen oxidase activity
I633_00155	COG3047	cAMP biosynthetic process
I633_00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I633_00250	COG2234	aminopeptidase activity
I633_00255	COG0463	Glycosyl transferase, family 2
I633_00265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I633_00290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_00320	COG3642	lipopolysaccharide core region biosynthetic process
I633_00365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I633_00380	COG3161	chorismate lyase activity
I633_00385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I633_00390	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I633_00405	COG0210	DNA helicase
I633_00455	COG1959	2 iron, 2 sulfur cluster binding
I633_00460	COG0730	response to heat
I633_00475	COG4771	TonB-dependent receptor
I633_00490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I633_00495	COG4988	ABC transporter
I633_00510	COG1271	oxidase subunit
I633_00530	COG0450	alkyl hydroperoxide reductase
I633_00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I633_00570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I633_00575	COG0318	PFAM AMP-dependent synthetase and ligase
I633_00605	COG1024	Enoyl-CoA hydratase
I633_00680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_00685	COG1129	ABC transporter
I633_00685	COG0842	Transport permease protein
I633_00690	COG0842	Transport permease protein
I633_00705	COG0643	Histidine kinase
I633_00705	COG2198	Histidine kinase
I633_00740	COG0583	DNA-binding transcription factor activity
I633_00750	COG3106	COG3106 Predicted ATPase
I633_00770	COG2184	nucleotidyltransferase activity
I633_00775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I633_00790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I633_00820	COG3071	HemY protein
I633_00840	COG0181	hydroxymethylbilane synthase activity
I633_00860	COG0194	GDP metabolic process
I633_00870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I633_00880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I633_00885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I633_00895	COG0678	peroxiredoxin activity
I633_00910	COG1178	ABC-type Fe3 transport system permease component
I633_00915	COG3842	ATPase activity
I633_00950	COG2963	transposase activity
I633_00970	COG2801	Transposase and inactivated derivatives
I633_00985	COG2200	EAL domain
I633_00990	COG0583	DNA-binding transcription factor activity
I633_01000	COG2076	Multidrug Resistance protein
I633_01020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_01045	COG0123	including yeast histone deacetylase and acetoin utilization protein
I633_01060	COG0840	transmembrane signaling receptor activity
I633_01070	COG3064	Membrane
I633_01080	COG5001	Diguanylate cyclase
I633_01080	COG5002	protein histidine kinase activity
I633_01105	COG2239	Acts as a magnesium transporter
I633_01110	COG2962	Rard protein
I633_01115	COG0745	RESPONSE REGULATOR receiver
I633_01115	COG3706	GGDEF domain
I633_01135	COG1011	Hydrolase
I633_01155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I633_01160	COG0019	diaminopimelate decarboxylase activity
I633_01195	COG0163	prenyltransferase activity
I633_01225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I633_01245	COG1077	Cell shape determining protein MreB Mrl
I633_01265	COG2814	Major facilitator Superfamily
I633_01270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_01335	COG0629	single-stranded DNA binding
I633_01350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I633_01445	COG3409	Peptidoglycan-binding domain 1 protein
I633_01445	COG3267	Type II secretory pathway component ExeA
I633_01460	COG1459	type II secretion system
I633_01505	COG1077	Cell shape determining protein MreB Mrl
I633_01510	COG1792	Involved in formation and maintenance of cell shape
I633_01515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I633_01525	COG1530	ribonuclease E activity
I633_01535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_01555	COG3028	Belongs to the UPF0307 family
I633_01560	COG0312	modulator of DNA gyrase
I633_01575	COG0745	RESPONSE REGULATOR receiver
I633_01580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_01580	COG4191	Histidine kinase
I633_01585	COG0297	glycogen (starch) synthase activity
I633_01600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I633_01620	COG3039	Transposase
I633_01660	COG0531	amino acid
I633_01670	COG2132	Multicopper oxidase
I633_01700	COG0745	RESPONSE REGULATOR receiver
I633_01720	COG0835	chemotaxis
I633_01735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I633_01750	COG0745	RESPONSE REGULATOR receiver
I633_01760	COG0835	chemotaxis
I633_01790	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I633_01840	COG0546	phosphoglycolate phosphatase activity
I633_01865	COG1609	Transcriptional regulator
I633_01870	COG0673	inositol 2-dehydrogenase activity
I633_01885	COG2211	Major facilitator Superfamily
I633_01890	COG1082	Xylose isomerase domain protein TIM barrel
I633_01910	COG1454	alcohol dehydrogenase
I633_01960	COG0089	rRNA binding
I633_01970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I633_01980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I633_01995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I633_02000	COG0438	transferase activity, transferring glycosyl groups
I633_02035	COG0840	transmembrane signaling receptor activity
I633_02055	COG0788	formyltetrahydrofolate deformylase activity
I633_02105	COG2354	Protein conserved in bacteria
I633_02110	COG4977	sequence-specific DNA binding
I633_02125	COG0004	ammonium transporteR
I633_02140	COG2837	iron assimilation
I633_02155	COG0540	Belongs to the ATCase OTCase family
I633_02225	COG1012	belongs to the aldehyde dehydrogenase family
I633_02235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I633_02250	COG0180	Tryptophanyl-tRNA synthetase
I633_02255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I633_02275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I633_02285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I633_02320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I633_02325	COG0281	malic enzyme
I633_02355	COG0753	catalase activity
I633_02370	COG5001	Diguanylate cyclase
I633_02370	COG3300	MHYT domain
I633_02375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I633_02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I633_02390	COG0137	argininosuccinate synthase activity
I633_02410	COG1803	Methylglyoxal synthase
I633_02420	COG0745	RESPONSE REGULATOR receiver
I633_02425	COG2205	protein histidine kinase activity
I633_02430	COG2267	carboxylic ester hydrolase activity
I633_02435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I633_02445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I633_02455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I633_02460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I633_02465	COG4942	peptidase
I633_02470	COG2861	carbohydrate metabolic process
I633_02480	COG0584	glycerophosphoryl diester phosphodiesterase
I633_02495	COG1162	GTPase activity
I633_02500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I633_02525	COG0028	Belongs to the TPP enzyme family
I633_02545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I633_02550	COG0805	protein transport
I633_02560	COG0084	hydrolase, TatD family'
I633_02565	COG5001	Diguanylate cyclase
I633_02565	COG4251	negative regulation of phosphorylation
I633_02565	COG3706	GGDEF domain
I633_02565	COG2203	Gaf domain
I633_02575	COG0248	Ppx GppA phosphatase
I633_02580	COG0513	Belongs to the DEAD box helicase family
I633_02585	COG3118	belongs to the thioredoxin family
I633_02590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I633_02600	COG5002	protein histidine kinase activity
I633_02600	COG0784	Response regulator, receiver
I633_02605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I633_02615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I633_02625	COG0783	Belongs to the Dps family
I633_02630	COG2133	pyrroloquinoline quinone binding
I633_02650	COG3118	belongs to the thioredoxin family
I633_02665	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I633_02675	COG1012	belongs to the aldehyde dehydrogenase family
I633_02730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I633_02740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I633_02750	COG0346	lactoylglutathione lyase activity
I633_02775	COG2824	Alkylphosphonate utilization operon protein PhnA
I633_02780	COG0454	-acetyltransferase
I633_02805	COG3093	addiction module antidote protein HigA
I633_02820	COG2026	Addiction module toxin, RelE StbE family
I633_02850	COG3093	addiction module antidote protein HigA
I633_02935	COG1024	Enoyl-CoA hydratase
I633_02935	COG1250	3-hydroxyacyl-CoA dehydrogenase
I633_02940	COG0741	lytic transglycosylase activity
I633_02950	COG0006	proline dipeptidase activity
I633_02960	COG0142	geranyltranstransferase activity
I633_03000	COG1238	metal cluster binding
I633_03010	COG0585	pseudouridine synthase activity
I633_03015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I633_03025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I633_03035	COG0840	transmembrane signaling receptor activity
I633_03040	COG0840	transmembrane signaling receptor activity
I633_03095	COG0730	response to heat
I633_03100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I633_03105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I633_03115	COG3706	GGDEF domain
I633_03115	COG0745	RESPONSE REGULATOR receiver
I633_03140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I633_03145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I633_03160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I633_03170	COG1648	precorrin-2 dehydrogenase activity
I633_03170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I633_03175	COG0513	Belongs to the DEAD box helicase family
I633_03195	COG1538	Outer membrane efflux protein
I633_03200	COG0494	nUDIX hydrolase
I633_03210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I633_03215	COG3150	esterase
I633_03240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_03265	COG1509	lysine 2,3-aminomutase activity
I633_03275	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I633_03290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I633_03295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I633_03310	COG0271	Belongs to the BolA IbaG family
I633_03325	COG3707	response regulator
I633_03340	COG0659	secondary active sulfate transmembrane transporter activity
I633_03345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I633_03355	COG0243	molybdopterin cofactor binding
I633_03360	COG1648	precorrin-2 dehydrogenase activity
I633_03360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I633_03365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I633_03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I633_03375	COG1116	anion transmembrane transporter activity
I633_03405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_03410	COG4206	TonB-dependent receptor
I633_03425	COG0348	domain, Protein
I633_03440	COG1960	acyl-CoA dehydrogenase activity
I633_03445	COG1028	Short-chain dehydrogenase reductase Sdr
I633_03455	COG4948	Mandelate Racemase Muconate Lactonizing
I633_03470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_03500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I633_03505	COG0358	DNA primase activity
I633_03535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I633_03540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I633_03555	COG0537	adenosine 5'-monophosphoramidase activity
I633_03570	COG3135	benzoate transporter
I633_03575	COG1396	sequence-specific DNA binding
I633_03590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_03590	COG4191	Histidine kinase
I633_03595	COG0745	RESPONSE REGULATOR receiver
I633_03600	COG5002	protein histidine kinase activity
I633_03625	COG0811	peptide transport
I633_03630	COG0811	peptide transport
I633_03635	COG0848	biopolymer transport protein
I633_03640	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I633_03650	COG3437	response regulator, receiver
I633_03660	COG0318	PFAM AMP-dependent synthetase and ligase
I633_03670	COG2133	pyrroloquinoline quinone binding
I633_03675	COG1049	propionate catabolic process, 2-methylcitrate cycle
I633_03680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I633_03725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I633_03730	COG2967	ApaG domain
I633_03740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I633_03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_03750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I633_03755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I633_03765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_03785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I633_03850	COG1028	Short-chain dehydrogenase reductase Sdr
I633_03865	COG0318	PFAM AMP-dependent synthetase and ligase
I633_03875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I633_03885	COG0463	Glycosyl transferase, family 2
I633_03905	COG0642	Histidine kinase
I633_03910	COG0745	RESPONSE REGULATOR receiver
I633_03925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I633_03930	COG0723	plastoquinol--plastocyanin reductase activity
I633_03935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I633_03950	COG0625	glutathione transferase activity
I633_03955	COG2969	positive regulation of protein catabolic process
I633_03960	COG2239	Acts as a magnesium transporter
I633_03965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I633_03975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I633_03985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I633_03990	COG1137	ATPase activity
I633_03995	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I633_04005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I633_04030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I633_04035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I633_04040	COG2854	intermembrane phospholipid transfer
I633_04050	COG5007	Belongs to the BolA IbaG family
I633_04075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I633_04145	COG0697	spore germination
I633_04155	COG0784	Response regulator, receiver
I633_04155	COG2205	protein histidine kinase activity
I633_04185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I633_04195	COG0126	phosphoglycerate kinase activity
I633_04200	COG3588	fructose-bisphosphate aldolase
I633_04210	COG0823	Involved in the tonB-independent uptake of proteins
I633_04210	COG1506	peptidase
I633_04210	COG4946	Tricorn protease homolog
I633_04225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I633_04235	COG0573	inorganic phosphate transmembrane transporter activity
I633_04250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I633_04260	COG0306	phosphate transporter
I633_04270	COG0583	DNA-binding transcription factor activity
I633_04280	COG1272	protein, Hemolysin III
I633_04285	COG1846	Transcriptional regulator
I633_04290	COG1764	response to oxidative stress
I633_04305	COG1739	Uncharacterized protein family UPF0029
I633_04315	COG0420	3'-5' exonuclease activity
I633_04335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I633_04365	COG2986	histidine ammonia-lyase
I633_04400	COG0488	(ABC) transporter
I633_04425	COG0668	transmembrane transport
I633_04455	COG0582	viral genome integration into host DNA
I633_04530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I633_04575	COG1346	cytolysis
I633_04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I633_04625	COG0513	Belongs to the DEAD box helicase family
I633_04655	COG0066	3-isopropylmalate dehydratase activity
I633_04665	COG0473	3-isopropylmalate dehydrogenase activity
I633_04670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I633_04690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I633_04705	COG4555	ABC transporter
I633_04710	COG1668	transmembrane transport
I633_04755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I633_04760	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I633_04770	COG1138	Cytochrome C-type biogenesis protein
I633_04775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I633_04790	COG2853	Lipoprotein
I633_04795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I633_04805	COG3104	oligopeptide transport
I633_04835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I633_04850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I633_04855	COG1596	polysaccharide export
I633_04855	COG1555	photosystem II stabilization
I633_04860	COG0473	3-isopropylmalate dehydrogenase activity
I633_04875	COG1611	Belongs to the LOG family
I633_04880	COG0745	RESPONSE REGULATOR receiver
I633_04880	COG3706	GGDEF domain
I633_04935	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I633_04940	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I633_05025	COG2204	response regulator
I633_05035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I633_05100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I633_05105	COG0024	Methionine aminopeptidase
I633_05110	COG0052	Belongs to the universal ribosomal protein uS2 family
I633_05120	COG0528	UMP kinase activity
I633_05130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I633_05170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I633_05210	COG0825	malonyl-CoA metabolic process
I633_05215	COG0037	tRNA processing
I633_05240	COG0590	tRNA wobble adenosine to inosine editing
I633_05270	COG2840	Smr protein MutS2
I633_05325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_05330	COG2197	response regulator
I633_05370	COG0835	chemotaxis
I633_05370	COG0784	Response regulator, receiver
I633_05375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I633_05380	COG1815	bacterial-type flagellum-dependent cell motility
I633_05385	COG1558	bacterial-type flagellum-dependent cell motility
I633_05390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I633_05395	COG1749	Flagellar hook protein flgE
I633_05400	COG4787	bacterial-type flagellum-dependent cell motility
I633_05405	COG4786	Flagellar basal body rod
I633_05420	COG1705	Flagellar rod assembly protein muramidase FlgJ
I633_05420	COG3951	Flagellar rod assembly protein muramidase FlgJ
I633_05425	COG1256	bacterial-type flagellum assembly
I633_05445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I633_05455	COG1334	flagellar protein FlaG
I633_05460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I633_05500	COG3980	spore coat polysaccharide biosynthesis protein
I633_05505	COG1083	cytidylyl-transferase
I633_05510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I633_05530	COG2204	response regulator
I633_05535	COG3852	Histidine kinase
I633_05550	COG1677	Flagellar hook-basal body complex protein FliE
I633_05565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I633_05620	COG1987	bacterial-type flagellum assembly
I633_05630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I633_05635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I633_05645	COG0455	bacterial-type flagellum organization
I633_05660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I633_05665	COG2198	Histidine kinase
I633_05665	COG0643	Histidine kinase
I633_05690	COG0835	chemotaxis
I633_05705	COG1410	methionine synthase
I633_05705	COG0646	methionine synthase
I633_05710	COG0646	methionine synthase
I633_05710	COG1410	methionine synthase
I633_05725	COG0583	DNA-binding transcription factor activity
I633_05730	COG0583	DNA-binding transcription factor activity
I633_05735	COG0288	reversible hydration of carbon dioxide
I633_05740	COG0659	secondary active sulfate transmembrane transporter activity
I633_05755	COG3590	peptidase
I633_05765	COG2137	regulation of response to DNA damage stimulus
I633_05800	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I633_05805	COG4172	Belongs to the ABC transporter superfamily
I633_05815	COG4171	peptide transport system, permease
I633_05820	COG4168	peptide transport system, permease
I633_05835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I633_05840	COG1842	Phage shock protein A
I633_05870	COG0625	glutathione transferase activity
I633_05875	COG1522	sequence-specific DNA binding
I633_05940	COG0811	peptide transport
I633_05945	COG0811	peptide transport
I633_05950	COG0848	biopolymer transport protein
I633_05965	COG1444	tRNA N-acetyltransferase activity
I633_06010	COG0456	acetyltransferase
I633_06025	COG0583	DNA-binding transcription factor activity
I633_06040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I633_06045	COG0656	L-ascorbic acid biosynthetic process
I633_06070	COG1846	Transcriptional regulator
I633_06185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I633_06195	COG3706	GGDEF domain
I633_06225	COG0543	2 iron, 2 sulfur cluster binding
I633_06225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I633_06235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I633_06240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I633_06245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I633_06250	COG0564	pseudouridine synthase activity
I633_06260	COG0612	Peptidase, M16
I633_06300	COG2840	Smr protein MutS2
I633_06305	COG2890	protein-(glutamine-N5) methyltransferase activity
I633_06320	COG2719	SpoVR family
I633_06325	COG2718	Belongs to the UPF0229 family
I633_06345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I633_06350	COG4771	TonB-dependent receptor
I633_06380	COG0450	alkyl hydroperoxide reductase
I633_06385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I633_06390	COG2885	chlorophyll binding
I633_06395	COG0584	glycerophosphoryl diester phosphodiesterase
I633_06400	COG0346	lactoylglutathione lyase activity
I633_06405	COG1278	Cold shock
I633_06420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I633_06425	COG4660	Part of a membrane complex involved in electron transport
I633_06430	COG4659	FMN binding
I633_06450	COG4656	Part of a membrane complex involved in electron transport
I633_06455	COG2878	Part of a membrane complex involved in electron transport
I633_06475	COG0556	nucleotide-excision repair
I633_06495	COG0602	queuosine metabolic process
I633_06505	COG0367	asparagine synthase
I633_06530	COG0471	metal ion transport
I633_06530	COG3273	potassium ion transport
I633_06545	COG0529	Catalyzes the synthesis of activated sulfate
I633_06550	COG0175	sulfate reduction
I633_06555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I633_06560	COG2203	Gaf domain
I633_06560	COG2199	diguanylate cyclase activity
I633_06595	COG2304	oxidoreductase activity
I633_06615	COG0714	Associated with various cellular activities
I633_06645	COG1025	Belongs to the peptidase M16 family
I633_06650	COG2062	phosphohistidine phosphatase, SixA
I633_06660	COG4536	flavin adenine dinucleotide binding
I633_06665	COG4137	Cytochrome C assembly protein
I633_06670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I633_06760	COG0228	four-way junction DNA binding
I633_06765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I633_06770	COG0336	Belongs to the RNA methyltransferase TrmD family
I633_06775	COG0335	large ribosomal subunit rRNA binding
I633_06780	COG2860	membrane
I633_06790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I633_06795	COG1605	Chorismate mutase
I633_06795	COG0287	Prephenate dehydrogenase
I633_06800	COG0077	Prephenate dehydratase
I633_06800	COG1605	Chorismate mutase
I633_06810	COG0023	Translation Initiation Factor
I633_06840	COG2205	protein histidine kinase activity
I633_06850	COG2204	response regulator
I633_06870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I633_06875	COG0494	nUDIX hydrolase
I633_06880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I633_06890	COG2255	four-way junction helicase activity
I633_06895	COG0824	Thioesterase
I633_06900	COG0811	peptide transport
I633_06925	COG2885	chlorophyll binding
I633_06930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I633_06935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I633_06955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I633_06975	COG3038	cytochrome b561
I633_06995	COG0583	DNA-binding transcription factor activity
I633_07000	COG1451	nucleotide metabolic process
I633_07010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I633_07020	COG1309	transcriptional regulator
I633_07025	COG4774	siderophore transport
I633_07050	COG3706	GGDEF domain
I633_07060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I633_07060	COG3008	intermembrane lipid transfer
I633_07090	COG0017	Asparaginyl-tRNA synthetase
I633_07105	COG0189	ligase activity
I633_07155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_07165	COG3340	Belongs to the peptidase S51 family
I633_07170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I633_07175	COG4139	cobalamin transport
I633_07210	COG5265	(ABC) transporter
I633_07215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I633_07225	COG0745	RESPONSE REGULATOR receiver
I633_07230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I633_07255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_07270	COG2755	lipolytic protein G-D-S-L family
I633_07275	COG4181	ATPase activity
I633_07280	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I633_07285	COG1090	epimerase
I633_07290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I633_07295	COG0628	permease
I633_07325	COG2350	Protein conserved in bacteria
I633_07330	COG0159	tryptophan synthase activity
I633_07340	COG0135	phosphoribosylanthranilate isomerase activity
I633_07340	COG0134	indole-3-glycerol-phosphate synthase activity
I633_07345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I633_07355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I633_07360	COG0613	PHP domain protein
I633_07365	COG0009	L-threonylcarbamoyladenylate synthase
I633_07370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I633_07375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I633_07385	COG0656	L-ascorbic acid biosynthetic process
I633_07390	COG0110	maltose O-acetyltransferase activity
I633_07400	COG2733	membrane
I633_07445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_07450	COG0500	methyltransferase
I633_07455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_07460	COG0497	DNA recombination
I633_07465	COG0783	Belongs to the Dps family
I633_07475	COG1454	alcohol dehydrogenase
I633_07480	COG1028	Short-chain dehydrogenase reductase Sdr
I633_07490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I633_07495	COG2610	gluconate transmembrane transporter activity
I633_07510	COG2198	Histidine kinase
I633_07510	COG0784	Response regulator, receiver
I633_07510	COG2205	protein histidine kinase activity
I633_07515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I633_07525	COG0484	heat shock protein binding
I633_07530	COG3909	cytochrome
I633_07535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_07555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I633_07560	COG0505	Belongs to the CarA family
I633_07575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I633_07595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I633_07620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I633_07625	COG4535	Mg2 and Co2 transporter CorC
I633_07635	COG1702	phosphate starvation-inducible protein PhoH
I633_07690	COG1607	acyl-coa hydrolase
I633_07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I633_07705	COG1115	amino acid carrier protein
I633_07710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I633_07715	COG0012	GTP binding
I633_07735	COG1064	alcohol dehydrogenase
I633_07750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I633_07755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I633_07760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I633_07780	COG2890	protein-(glutamine-N5) methyltransferase activity
I633_07785	COG3437	response regulator, receiver
I633_07785	COG0784	Response regulator, receiver
I633_07790	COG3094	Invasion gene expression up-regulator, SirB
I633_07820	COG2363	Small membrane protein
I633_07840	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I633_07845	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I633_07850	COG0515	serine threonine protein kinase
I633_07875	COG0714	Associated with various cellular activities
I633_07880	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I633_07885	COG0033	Phosphoglucomutase
I633_07955	COG1393	Belongs to the ArsC family
I633_07985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I633_08020	COG3300	MHYT domain
I633_08020	COG5001	Diguanylate cyclase
I633_08050	COG2249	NAD(P)H dehydrogenase (quinone) activity
I633_08075	COG1733	regulation of RNA biosynthetic process
I633_08080	COG3447	MASE1 domain protein
I633_08080	COG5002	protein histidine kinase activity
I633_08080	COG5001	Diguanylate cyclase
I633_08090	COG0402	S-adenosylhomocysteine deaminase activity
I633_08095	COG2351	hydroxyisourate hydrolase activity
I633_08115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I633_08125	COG1309	transcriptional regulator
I633_08150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I633_08165	COG5001	Diguanylate cyclase
I633_08165	COG4251	negative regulation of phosphorylation
I633_08165	COG3706	GGDEF domain
I633_08165	COG2203	Gaf domain
I633_08170	COG4251	negative regulation of phosphorylation
I633_08170	COG3706	GGDEF domain
I633_08170	COG2203	Gaf domain
I633_08170	COG5001	Diguanylate cyclase
I633_08175	COG2205	protein histidine kinase activity
I633_08175	COG0784	Response regulator, receiver
I633_08195	COG2233	PERMEase
I633_08220	COG0730	response to heat
I633_08270	COG1028	Short-chain dehydrogenase reductase Sdr
I633_08285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I633_08320	COG1596	polysaccharide export
I633_08325	COG0489	protein tyrosine kinase activity
I633_08330	COG4464	protein tyrosine phosphatase activity
I633_08395	COG1216	Glycosyl transferase, family 2
I633_08445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I633_08445	COG2755	lipolytic protein G-D-S-L family
I633_08450	COG1215	transferase activity, transferring glycosyl groups
I633_08455	COG0438	transferase activity, transferring glycosyl groups
I633_08465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I633_08480	COG0072	phenylalanine-tRNA ligase activity
I633_08480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_08505	COG1472	Belongs to the glycosyl hydrolase 3 family
I633_08510	COG2096	Adenosyltransferase
I633_08535	COG4591	ABC-type transport system involved in lipoprotein release permease component
I633_08580	COG0708	Exodeoxyribonuclease III
I633_08620	COG2814	Major facilitator Superfamily
I633_08670	COG1024	Enoyl-CoA hydratase
I633_08675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I633_08680	COG1960	acyl-CoA dehydrogenase activity
I633_08685	COG0789	Transcriptional regulator
I633_08710	COG3706	GGDEF domain
I633_08825	COG0328	RNA-DNA hybrid ribonuclease activity
I633_08830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I633_08840	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_08850	COG4591	ABC-type transport system involved in lipoprotein release permease component
I633_08870	COG3724	N-succinylarginine dihydrolase activity
I633_08900	COG0746	molybdenum cofactor guanylyltransferase activity
I633_08915	COG0243	molybdopterin cofactor binding
I633_08920	COG2153	protein acetylation
I633_08935	COG1530	ribonuclease E activity
I633_08940	COG0564	pseudouridine synthase activity
I633_08955	COG0424	maF-like protein
I633_08960	COG1399	metal-binding, possibly nucleic acid-binding protein
I633_08970	COG0416	fatty acid biosynthetic process
I633_08985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I633_08995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I633_09000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I633_09010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I633_09025	COG0084	hydrolase, TatD family'
I633_09035	COG0702	epimerase
I633_09040	COG0745	RESPONSE REGULATOR receiver
I633_09040	COG3706	GGDEF domain
I633_09065	COG1028	Short-chain dehydrogenase reductase Sdr
I633_09070	COG0596	Alpha beta hydrolase
I633_09080	COG0183	Belongs to the thiolase family
I633_09085	COG1960	acyl-CoA dehydrogenase activity
I633_09105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I633_09115	COG0246	Mannitol dehydrogenase
I633_09150	COG4771	TonB-dependent receptor
I633_09170	COG3437	response regulator, receiver
I633_09180	COG0195	Participates in both transcription termination and antitermination
I633_09195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I633_09205	COG1187	pseudouridine synthase activity
I633_09215	COG3153	acetyltransferase
I633_09215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_09255	COG0450	alkyl hydroperoxide reductase
I633_09340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_09350	COG4134	Bacterial extracellular solute-binding protein
I633_09365	COG4136	ATPase activity
I633_09370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I633_09390	COG4251	negative regulation of phosphorylation
I633_09390	COG2203	Gaf domain
I633_09390	COG3706	GGDEF domain
I633_09390	COG5001	Diguanylate cyclase
I633_09500	COG1902	pentaerythritol trinitrate reductase activity
I633_09500	COG0446	pyridine nucleotide-disulphide oxidoreductase
I633_09510	COG2867	negative regulation of translational initiation
I633_09515	COG2914	Belongs to the UPF0125 (RnfH) family
I633_09535	COG4771	TonB-dependent receptor
I633_09560	COG0574	Belongs to the PEP-utilizing enzyme family
I633_09560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I633_09595	COG2850	peptidyl-arginine hydroxylation
I633_09615	COG2915	High frequency lysogenization protein hflD homolog
I633_09620	COG0482	sulfurtransferase activity
I633_09625	COG1187	pseudouridine synthase activity
I633_09640	COG1278	Cold shock
I633_09645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I633_09650	COG0542	response to heat
I633_09655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I633_09660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I633_09665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I633_09670	COG0492	ferredoxin-NADP+ reductase activity
I633_09675	COG3092	negative regulation of chromosome organization
I633_09680	COG3091	SprT-like family
I633_09685	COG0616	signal peptide processing
I633_09700	COG0778	Nitroreductase
I633_09710	COG0252	asparaginase activity
I633_09715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I633_09720	COG0321	lipoyl(octanoyl) transferase activity
I633_09725	COG2921	Belongs to the UPF0250 family
I633_09730	COG1686	Belongs to the peptidase S11 family
I633_09745	COG0772	Belongs to the SEDS family
I633_09765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I633_09770	COG0799	negative regulation of ribosome biogenesis
I633_09780	COG1466	dna polymerase III delta subunit
I633_09785	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I633_09790	COG0495	leucyl-tRNA aminoacylation
I633_09795	COG1067	ATP-dependent peptidase activity
I633_09800	COG0596	Alpha beta hydrolase
I633_09805	COG3706	GGDEF domain
I633_09815	COG1534	Rna-binding protein
I633_09820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I633_09825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_09830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I633_09835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I633_09840	COG0149	triose-phosphate isomerase activity
I633_09845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I633_09850	COG3300	MHYT domain
I633_09850	COG5001	Diguanylate cyclase
I633_09875	COG1597	lipid kinase activity
I633_09875	COG1803	Methylglyoxal synthase
I633_09885	COG1028	Short-chain dehydrogenase reductase Sdr
I633_09890	COG0561	phosphatase activity
I633_09905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I633_09930	COG1185	polyribonucleotide nucleotidyltransferase activity
I633_10130	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I633_10135	COG1196	nuclear chromosome segregation
I633_10145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I633_10165	COG1132	(ABC) transporter
I633_10170	COG1663	tetraacyldisaccharide 4'-kinase activity
I633_10205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I633_10210	COG0435	Glutathione S-transferase
I633_10215	COG1741	Belongs to the pirin family
I633_10220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I633_10230	COG0372	Belongs to the citrate synthase family
I633_10235	COG2009	succinate dehydrogenase
I633_10240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I633_10245	COG1053	succinate dehydrogenase
I633_10250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I633_10255	COG0567	Dehydrogenase, E1 component
I633_10260	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_10325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_10345	COG4191	Histidine kinase
I633_10365	COG2814	Major facilitator Superfamily
I633_10395	COG0366	Alpha amylase catalytic
I633_10420	COG1028	Short-chain dehydrogenase reductase Sdr
I633_10425	COG2267	carboxylic ester hydrolase activity
I633_10435	COG0616	signal peptide processing
I633_10455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_10460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I633_10465	COG0386	Belongs to the glutathione peroxidase family
I633_10470	COG2084	Dehydrogenase
I633_10490	COG1960	acyl-CoA dehydrogenase activity
I633_10495	COG1024	Enoyl-CoA hydratase
I633_10505	COG2226	methyltransferase
I633_10510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I633_10515	COG3083	sulfuric ester hydrolase activity
I633_10520	COG3082	Protein of unknown function (DUF1414)
I633_10525	COG3081	Nucleoid-associated protein
I633_10555	COG3275	phosphorelay sensor kinase activity
I633_10560	COG3279	Response regulator of the LytR AlgR family
I633_10565	COG0205	6-phosphofructokinase activity
I633_10585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_10605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_10605	COG2205	protein histidine kinase activity
I633_10625	COG0513	Belongs to the DEAD box helicase family
I633_10635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I633_10640	COG0583	DNA-binding transcription factor activity
I633_10660	COG1760	l-serine dehydratase
I633_10685	COG1322	Protein conserved in bacteria
I633_10700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I633_10705	COG0022	dehydrogenase e1 component
I633_10740	COG1946	Acyl-CoA thioesterase
I633_10765	COG1956	GAF domain-containing protein
I633_10790	COG0733	neurotransmitter:sodium symporter activity
I633_10800	COG0308	aminopeptidase N
I633_10840	COG0167	dihydroorotate dehydrogenase activity
I633_10870	COG3130	regulation of translation
I633_10890	COG0415	Belongs to the DNA photolyase family
I633_10905	COG0415	Belongs to the DNA photolyase family
I633_10910	COG3046	protein related to deoxyribodipyrimidine photolyase
I633_10975	COG0640	Transcriptional regulator
I633_11050	COG4772	TonB-dependent receptor
I633_11110	COG4974	Belongs to the 'phage' integrase family
I633_11120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I633_11125	COG0589	response to stress
I633_11135	COG0069	glutamate synthase activity
I633_11150	COG2193	ferroxidase activity
I633_11180	COG2010	Cytochrome c
I633_11210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I633_11215	COG0589	response to stress
I633_11220	COG0037	tRNA processing
I633_11225	COG1752	Esterase of the alpha-beta hydrolase superfamily
I633_11245	COG1280	lysine exporter protein (LysE YggA)
I633_11250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I633_11255	COG2897	thiosulfate sulfurtransferase activity
I633_11260	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I633_11275	COG0322	excinuclease ABC activity
I633_11290	COG0436	Aminotransferase
I633_11295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I633_11305	COG2259	Doxx family
I633_11310	COG0583	DNA-binding transcription factor activity
I633_11325	COG0670	Belongs to the BI1 family
I633_11330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I633_11345	COG2920	part of a sulfur-relay system
I633_11365	COG4206	TonB-dependent receptor
I633_11365	COG4206	TonB-dependent receptor
I633_11380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I633_11405	COG0686	Belongs to the AlaDH PNT family
I633_11410	COG0284	orotidine-5'-phosphate decarboxylase activity
I633_11415	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I633_11430	COG0776	regulation of translation
I633_11435	COG0539	negative regulation of cytoplasmic translation
I633_11440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I633_11445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I633_11450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I633_11460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I633_11475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I633_11480	COG0633	Ferredoxin
I633_11525	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I633_11530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I633_11540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I633_11550	COG4783	chaperone-mediated protein folding
I633_11560	COG1393	Belongs to the ArsC family
I633_11575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I633_11590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I633_11630	COG0572	uridine kinase
I633_11635	COG3769	mannosylglycerate metabolic process
I633_11640	COG1215	transferase activity, transferring glycosyl groups
I633_11660	COG0303	'Molybdopterin
I633_11685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I633_11690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I633_11715	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I633_11780	COG1024	Enoyl-CoA hydratase
I633_11845	COG1671	Belongs to the UPF0178 family
I633_11860	COG1028	Short-chain dehydrogenase reductase Sdr
I633_11865	COG1960	acyl-CoA dehydrogenase activity
I633_11870	COG0662	Cupin 2, conserved barrel domain protein
I633_11870	COG2207	Transcriptional regulator
I633_11885	COG1505	serine-type exopeptidase activity
I633_11895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_11925	COG0596	Alpha beta hydrolase
I633_11930	COG0716	FMN binding
I633_11940	COG0735	belongs to the Fur family
I633_11955	COG1984	allophanate hydrolase subunit 2
I633_11960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I633_11965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I633_11970	COG2996	Protein conserved in bacteria
I633_11980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_12005	COG0436	Aminotransferase
I633_12010	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_12015	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_12035	COG2080	2 iron, 2 sulfur cluster binding
I633_12060	COG1073	alpha beta
I633_12065	COG2207	Transcriptional regulator
I633_12070	COG4584	PFAM Integrase catalytic
I633_12095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_12100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I633_12125	COG3012	SEC-C Motif Domain Protein
I633_12145	COG1960	acyl-CoA dehydrogenase activity
I633_12160	COG4771	TonB-dependent receptor
I633_12180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I633_12185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I633_12205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I633_12210	COG0315	cyclic pyranopterin monophosphate synthase activity
I633_12215	COG0521	Mo-molybdopterin cofactor biosynthetic process
I633_12230	COG2161	toxin-antitoxin pair type II binding
I633_12235	COG4115	mRNA cleavage
I633_12260	COG3268	Saccharopine dehydrogenase
I633_12285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I633_12290	COG4206	TonB-dependent receptor
I633_12300	COG5006	permease, DMT superfamily
I633_12335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I633_12350	COG1022	Amp-dependent synthetase and ligase
I633_12380	COG0583	DNA-binding transcription factor activity
I633_12400	COG0640	Transcriptional regulator
I633_12420	COG2204	response regulator
I633_12430	COG4251	negative regulation of phosphorylation
I633_12435	COG0784	Response regulator, receiver
I633_12440	COG0784	Response regulator, receiver
I633_12440	COG2205	protein histidine kinase activity
I633_12465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I633_12490	COG3139	Protein of unknown function (DUF1315)
I633_12505	COG1115	amino acid carrier protein
I633_12535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I633_12555	COG1640	4-alpha-glucanotransferase
I633_12560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I633_12565	COG0676	glucose-6-phosphate 1-epimerase activity
I633_12570	COG0800	Aldolase
I633_12580	COG0129	dihydroxy-acid dehydratase activity
I633_12590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I633_12595	COG1737	Transcriptional regulator
I633_12600	COG0469	pyruvate kinase activity
I633_12630	COG2823	Periplasmic or secreted lipoprotein
I633_12660	COG3665	Urea carboxylase-associated protein
I633_12680	COG1028	Short-chain dehydrogenase reductase Sdr
I633_12695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I633_12710	COG2721	sulfolactate sulfo-lyase activity
I633_12715	COG1904	glucuronate isomerase
I633_12740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_12745	COG2755	lipolytic protein G-D-S-L family
I633_12810	COG0840	transmembrane signaling receptor activity
I633_12825	COG0583	DNA-binding transcription factor activity
I633_12830	COG1979	alcohol dehydrogenase
I633_12845	COG3437	response regulator, receiver
I633_12845	COG0784	Response regulator, receiver
I633_12850	COG4191	Histidine kinase
I633_12850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I633_12875	COG0489	protein tyrosine kinase activity
I633_12880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_12880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I633_12885	COG0668	transmembrane transport
I633_12890	COG2226	methyltransferase
I633_12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_12900	COG0741	lytic transglycosylase activity
I633_12900	COG1388	LysM domain
I633_12920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I633_12925	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I633_12935	COG2268	Band 7 protein
I633_12950	COG1733	regulation of RNA biosynthetic process
I633_12955	COG0604	alcohol dehydrogenase
I633_12960	COG0753	catalase activity
I633_12965	COG0604	alcohol dehydrogenase
I633_13000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I633_13005	COG1286	toxin biosynthetic process
I633_13010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I633_13015	COG0285	dihydrofolate synthase activity
I633_13035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I633_13040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I633_13060	COG3609	addiction module antidote protein, CC2985 family
I633_13065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I633_13070	COG0318	PFAM AMP-dependent synthetase and ligase
I633_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I633_13080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I633_13130	COG0604	alcohol dehydrogenase
I633_13160	COG2031	fatty acid transporter
I633_13180	COG0612	Peptidase, M16
I633_13195	COG3101	peptidyl-lysine hydroxylation
I633_13220	COG0446	pyridine nucleotide-disulphide oxidoreductase
I633_13220	COG1902	pentaerythritol trinitrate reductase activity
I633_13260	COG4399	Belongs to the UPF0754 family
I633_13285	COG1770	oligopeptidase
I633_13305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I633_13310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I633_13325	COG2983	Belongs to the UPF0260 family
I633_13330	COG0179	Fumarylacetoacetate (FAA) hydrolase
I633_13345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I633_13350	COG0318	PFAM AMP-dependent synthetase and ligase
I633_13355	COG2267	carboxylic ester hydrolase activity
I633_13370	COG1214	PFAM Peptidase M22, glycoprotease
I633_13450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I633_13455	COG4771	TonB-dependent receptor
I633_13465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I633_13470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I633_13475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I633_13490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I633_13505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I633_13505	COG0140	phosphoribosyl-ATP diphosphatase activity
I633_13555	COG0326	Molecular chaperone. Has ATPase activity
I633_13560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I633_13580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I633_13585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I633_13595	COG3220	belongs to the UPF0276 family
I633_13605	COG0577	efflux transmembrane transporter activity
I633_13605	COG1136	(ABC) transporter
I633_13615	COG1183	phosphatidylcholine synthase activity
I633_13635	COG0277	FAD linked oxidase domain protein
I633_13640	COG0542	response to heat
I633_13650	COG0564	pseudouridine synthase activity
I633_13665	COG1595	DNA-templated transcription, initiation
I633_13680	COG4221	oxidoreductase activity
I633_13695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I633_13705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I633_13730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I633_13735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I633_13745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I633_13760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I633_13760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I633_13795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I633_13820	COG0084	hydrolase, TatD family'
I633_13835	COG0571	ribonuclease III activity
I633_13840	COG0681	Belongs to the peptidase S26 family
I633_13870	COG1595	DNA-templated transcription, initiation
I633_13880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I633_13895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I633_13990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I633_14020	COG0196	riboflavin kinase activity
I633_14025	COG0728	peptidoglycan biosynthetic process
I633_14030	COG0268	Binds directly to 16S ribosomal RNA
I633_14050	COG0385	Bile acid
I633_14055	COG0583	DNA-binding transcription factor activity
I633_14090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_14095	COG0776	regulation of translation
I633_14100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I633_14115	COG0740	serine-type endopeptidase activity
I633_14120	COG0544	peptidyl-prolyl cis-trans isomerase activity
I633_14140	COG1720	tRNA m6t6A37 methyltransferase activity
I633_14150	COG1234	tRNA 3'-trailer cleavage
I633_14160	COG0123	including yeast histone deacetylase and acetoin utilization protein
I633_14175	COG0517	IMP dehydrogenase activity
I633_14175	COG0516	GMP reductase activity
I633_14180	COG1570	exodeoxyribonuclease VII activity
I633_14205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I633_14210	COG2976	Protein conserved in bacteria
I633_14235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I633_14245	COG2166	iron-sulfur cluster assembly
I633_14270	COG0719	Fe-S assembly protein
I633_14275	COG0396	ATPase activity
I633_14280	COG0719	Fe-S assembly protein
I633_14285	COG1104	cysteine desulfurase activity
I633_14290	COG1959	2 iron, 2 sulfur cluster binding
I633_14295	COG2072	flavoprotein involved in K transport
I633_14310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I633_14315	COG0483	inositol monophosphate 1-phosphatase activity
I633_14335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I633_14340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I633_14345	COG1862	Preprotein translocase
I633_14350	COG0343	queuine tRNA-ribosyltransferase activity
I633_14370	COG1842	Phage shock protein A
I633_14375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I633_14440	COG2066	Belongs to the glutaminase family
I633_14445	COG1785	Belongs to the alkaline phosphatase family
I633_14520	COG0438	transferase activity, transferring glycosyl groups
I633_14540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I633_14545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I633_14580	COG5002	protein histidine kinase activity
I633_14585	COG3328	transposase activity
I633_14595	COG0438	transferase activity, transferring glycosyl groups
I633_14610	COG0367	asparagine synthase
I633_14625	COG2244	polysaccharide biosynthetic process
I633_14640	COG0463	Glycosyl transferase, family 2
I633_14655	COG0367	asparagine synthase
I633_14690	COG0489	protein tyrosine kinase activity
I633_14700	COG3267	Type II secretory pathway component ExeA
I633_14700	COG3409	Peptidoglycan-binding domain 1 protein
I633_14740	COG1560	Kdo2-lipid A biosynthetic process
I633_14775	COG3300	MHYT domain
I633_14775	COG5001	Diguanylate cyclase
I633_14780	COG1435	thymidine kinase activity
I633_14790	COG1609	Transcriptional regulator
I633_14795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I633_14835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I633_14885	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I633_14910	COG1960	acyl-CoA dehydrogenase activity
I633_14930	COG0745	RESPONSE REGULATOR receiver
I633_14935	COG2205	protein histidine kinase activity
I633_14945	COG3682	Transcriptional regulator
I633_14980	COG2080	2 iron, 2 sulfur cluster binding
I633_14985	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I633_14990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I633_15015	COG1028	Short-chain dehydrogenase reductase Sdr
I633_15030	COG0693	protein deglycase activity
I633_15035	COG1295	ribonuclease BN
I633_15045	COG4681	YaeQ
I633_15080	COG2814	Major facilitator Superfamily
I633_15095	COG0514	ATP-dependent DNA helicase (RecQ)
I633_15130	COG4251	negative regulation of phosphorylation
I633_15135	COG2133	pyrroloquinoline quinone binding
I633_15140	COG3550	peptidyl-serine autophosphorylation
I633_15160	COG2801	Transposase and inactivated derivatives
I633_15180	COG2203	Gaf domain
I633_15180	COG3706	GGDEF domain
I633_15180	COG5001	Diguanylate cyclase
I633_15180	COG4251	negative regulation of phosphorylation
I633_15240	COG5001	Diguanylate cyclase
I633_15240	COG5002	protein histidine kinase activity
I633_15325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I633_15330	COG2971	BadF BadG BcrA BcrD
I633_15335	COG0583	DNA-binding transcription factor activity
I633_15340	COG1620	l-lactate permease
I633_15370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I633_15375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I633_15380	COG0006	proline dipeptidase activity
I633_15390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_15405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I633_15410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I633_15415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I633_15435	COG3313	Fe-S protein
I633_15455	COG0583	DNA-binding transcription factor activity
I633_15470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_15475	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_15480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I633_15485	COG2186	Transcriptional regulator
I633_15495	COG3023	N-Acetylmuramoyl-L-alanine amidase
I633_15500	COG3577	Aspartyl protease
I633_15505	COG0157	Belongs to the NadC ModD family
I633_15525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I633_15530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I633_15530	COG0237	dephospho-CoA kinase activity
I633_15555	COG0494	nUDIX hydrolase
I633_15570	COG0739	heme binding
I633_15575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I633_15580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I633_15585	COG0849	cell division
I633_15590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I633_15595	COG1181	Belongs to the D-alanine--D-alanine ligase family
I633_15600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I633_15625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I633_15635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I633_15640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I633_15645	COG0768	penicillin binding
I633_15650	COG3116	cell division
I633_15660	COG2001	Belongs to the MraZ family
I633_15680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I633_15685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_15710	COG0678	peroxiredoxin activity
I633_15710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I633_15725	COG3706	GGDEF domain
I633_15735	COG2204	response regulator
I633_15740	COG2205	protein histidine kinase activity
I633_15740	COG0784	Response regulator, receiver
I633_15765	COG0668	transmembrane transport
I633_15770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I633_15775	COG0189	ligase activity
I633_15780	COG1678	Uncharacterized ACR, COG1678
I633_15785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I633_15810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I633_15830	COG0446	pyridine nucleotide-disulphide oxidoreductase
I633_15830	COG1902	pentaerythritol trinitrate reductase activity
I633_15845	COG0625	glutathione transferase activity
I633_15855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I633_15870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I633_15880	COG2814	Major facilitator Superfamily
I633_15885	COG0724	RNA recognition motif
I633_15925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I633_15930	COG0083	homoserine kinase activity
I633_15955	COG0583	DNA-binding transcription factor activity
I633_15970	COG0640	Transcriptional regulator
I633_15980	COG0431	NADPH-dependent FMN reductase
I633_15985	COG0798	PFAM Bile acid sodium symporter
I633_15990	COG2201	protein-glutamate methylesterase activity
I633_15995	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I633_16005	COG5002	protein histidine kinase activity
I633_16005	COG3850	Histidine kinase
I633_16055	COG1748	Saccharopine dehydrogenase
I633_16070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I633_16075	COG3107	peptidoglycan biosynthetic process
I633_16085	COG0438	transferase activity, transferring glycosyl groups
I633_16095	COG2823	Periplasmic or secreted lipoprotein
I633_16125	COG2197	response regulator
I633_16140	COG4771	TonB-dependent receptor
I633_16150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I633_16155	COG0372	Belongs to the citrate synthase family
I633_16160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I633_16210	COG3023	N-Acetylmuramoyl-L-alanine amidase
I633_16235	COG0493	'glutamate synthase
I633_16250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I633_16255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I633_16260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I633_16280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I633_16285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I633_16295	COG4942	peptidase
I633_16330	COG1902	pentaerythritol trinitrate reductase activity
I633_16355	COG0625	glutathione transferase activity
I633_16385	COG2894	cell division
I633_16390	COG0850	regulation of cytokinetic process
I633_16400	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I633_16470	COG0174	glutamine synthetase
I633_16480	COG3852	Histidine kinase
I633_16500	COG3437	response regulator, receiver
I633_16505	COG0204	Acyl-transferase
I633_16520	COG3706	GGDEF domain
I633_16550	COG0525	valine-tRNA ligase activity
I633_16555	COG2927	DNA polymerase III (CHI subunit)
I633_16560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I633_16575	COG0795	lipopolysaccharide-transporting ATPase activity
I633_16690	COG2856	Zn peptidase
I633_16755	COG3250	beta-galactosidase activity
I633_16795	COG2199	diguanylate cyclase activity
I633_16795	COG2203	Gaf domain
I633_16820	COG0673	inositol 2-dehydrogenase activity
I633_16835	COG0628	permease
I633_16850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I633_16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I633_16890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I633_16895	COG0697	spore germination
I633_16930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I633_16950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I633_16955	COG0745	RESPONSE REGULATOR receiver
I633_16955	COG3706	GGDEF domain
I633_16960	COG0679	Auxin Efflux Carrier
I633_16995	COG1131	(ABC) transporter
I633_17005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I633_17015	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I633_17055	COG2205	protein histidine kinase activity
I633_17070	COG3901	Regulator of nitric oxide reductase transcription
I633_17070	COG0348	domain, Protein
I633_17090	COG2197	response regulator
I633_17130	COG0277	FAD linked oxidase domain protein
I633_17145	COG1462	curli production assembly transport component CsgG
I633_17180	COG2197	response regulator
I633_17215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_17230	COG3264	Mechanosensitive ion channel
I633_17230	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I633_17280	COG0730	response to heat
I633_17330	COG0417	DNA replication proofreading
I633_17340	COG0318	PFAM AMP-dependent synthetase and ligase
I633_17360	COG1309	transcriptional regulator
I633_17370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_17380	COG1573	uracil-dna glycosylase
I633_17385	COG5001	Diguanylate cyclase
I633_17385	COG3300	MHYT domain
I633_17405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I633_17425	COG1983	PspC domain protein
I633_17430	COG1842	Phage shock protein A
I633_17440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_17465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I633_17465	COG2885	chlorophyll binding
I633_17470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I633_17485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I633_17490	COG0204	Acyl-transferase
I633_17495	COG0204	Acyl-transferase
I633_17500	COG0668	transmembrane transport
I633_17520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I633_17550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I633_17565	COG0716	FMN binding
I633_17575	COG0848	biopolymer transport protein
I633_17600	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I633_17630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I633_17635	COG0702	epimerase
I633_17650	COG5001	Diguanylate cyclase
I633_17650	COG5002	protein histidine kinase activity
I633_17665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I633_17675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_17685	COG0583	DNA-binding transcription factor activity
I633_17690	COG0121	glutamine amidotransferase
I633_17695	COG4682	membrane
I633_17715	COG1953	Uracil, thiamine, allantoin
I633_17720	COG4771	TonB-dependent receptor
I633_17730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I633_17740	COG0596	Alpha beta hydrolase
I633_17745	COG0251	oxidation-reduction process
I633_17760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I633_17785	COG4628	conserved protein (DUF2132)
I633_17790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I633_17815	COG1477	protein flavinylation
I633_17820	COG2871	sodium ion transport
I633_17825	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_17830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_17835	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_17840	COG1805	sodium ion transport
I633_17845	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I633_17865	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I633_17870	COG0545	Peptidyl-prolyl cis-trans isomerase
I633_17875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I633_17895	COG0039	L-malate dehydrogenase activity
I633_17900	COG1438	arginine binding
I633_17930	COG0572	uridine kinase
I633_17935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I633_17955	COG0745	RESPONSE REGULATOR receiver
I633_17955	COG3706	GGDEF domain
I633_17960	COG2176	DNA-directed DNA polymerase activity
I633_18005	COG0189	ligase activity
I633_18020	COG0189	ligase activity
I633_18020	COG4067	protein conserved in archaea
I633_18045	COG1283	sodium-dependent phosphate transmembrane transporter activity
I633_18050	COG0667	Aldo Keto reductase
I633_18065	COG5001	Diguanylate cyclase
I633_18080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I633_18090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I633_18110	COG2274	protein secretion by the type I secretion system
I633_18115	COG0583	DNA-binding transcription factor activity
I633_18225	COG1051	belongs to the nudix hydrolase family
I633_18230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I633_18250	COG2963	transposase activity
I633_18260	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I633_18275	COG0438	transferase activity, transferring glycosyl groups
I633_18310	COG0662	Cupin 2, conserved barrel domain protein
I633_18310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I633_18335	COG2161	toxin-antitoxin pair type II binding
I633_18345	COG0202	RNA polymerase activity
I633_18400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I633_18435	COG0784	Response regulator, receiver
I633_18435	COG5002	protein histidine kinase activity
I633_18505	COG4771	TonB-dependent receptor
I633_18520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I633_18595	COG1294	oxidase, subunit
I633_18605	COG1522	sequence-specific DNA binding
I633_18615	COG1278	Cold shock
I633_18650	COG0339	signal peptide processing
I633_18655	COG2201	protein-glutamate methylesterase activity
I633_18665	COG3852	Histidine kinase
I633_18675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I633_18680	COG0243	molybdopterin cofactor binding
I633_18685	COG0823	Involved in the tonB-independent uptake of proteins
I633_18685	COG1506	peptidase
I633_18685	COG4946	Tricorn protease homolog
I633_18735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I633_18745	COG2197	response regulator
I633_18780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I633_18785	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I633_18790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I633_18805	COG0281	malic enzyme
I633_18815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I633_18845	COG0456	acetyltransferase
I633_18855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I633_18860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I633_18865	COG2177	Part of the ABC transporter FtsEX involved in
I633_18880	COG0552	protein localization to endoplasmic reticulum
I633_18885	COG0742	ribosomal rna small subunit methyltransferase
I633_18895	COG2095	MarC family integral membrane protein
I633_18925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I633_18930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I633_18935	COG0617	tRNA 3'-terminal CCA addition
I633_18940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I633_18955	COG0076	glutamate decarboxylase activity
I633_18970	COG0842	Transport permease protein
I633_18985	COG0745	RESPONSE REGULATOR receiver
I633_19000	COG4774	siderophore transport
I633_19045	COG1966	Carbon starvation protein
I633_19070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I633_19075	COG0049	tRNA binding
I633_19080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I633_19085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I633_19105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I633_19110	COG0081	regulation of translation
I633_19115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I633_19135	COG0250	Participates in transcription elongation, termination and antitermination
I633_19140	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I633_19155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I633_19175	COG0513	Belongs to the DEAD box helicase family
I633_19180	COG0418	dihydroorotase activity
I633_19185	COG3040	lipid binding
I633_19190	COG4989	oxidoreductase activity
I633_19195	COG0346	lactoylglutathione lyase activity
I633_19200	COG0668	transmembrane transport
I633_19220	COG0302	gtp cyclohydrolase
I633_19240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I633_19265	COG1793	dna ligase
I633_19270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I633_19275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I633_19285	COG1410	methionine synthase
I633_19285	COG0646	methionine synthase
I633_19290	COG0625	glutathione transferase activity
I633_19310	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I633_19325	COG1012	belongs to the aldehyde dehydrogenase family
I633_19330	COG0028	Belongs to the TPP enzyme family
I633_19340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I633_19355	COG0330	HflC and HflK could
I633_19360	COG0330	HflC and HflK could
I633_19365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I633_19370	COG1923	regulation of RNA biosynthetic process
I633_19375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I633_19390	COG0802	atpase or kinase
I633_19405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I633_19430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I633_19435	COG0735	belongs to the Fur family
I633_19445	COG0432	Pfam Uncharacterised protein family UPF0047
I633_19455	COG0305	Participates in initiation and elongation during chromosome replication
I633_19480	COG2258	MOSC domain
I633_19510	COG0784	Response regulator, receiver
I633_19510	COG2198	Histidine kinase
I633_19510	COG2205	protein histidine kinase activity
I633_19520	COG1136	(ABC) transporter
I633_19520	COG0577	efflux transmembrane transporter activity
I633_19530	COG0840	transmembrane signaling receptor activity
I633_19535	COG5002	protein histidine kinase activity
I633_19540	COG0840	transmembrane signaling receptor activity
I633_19605	COG2723	6-phospho-beta-galactosidase activity
I633_19610	COG1609	Transcriptional regulator
I633_19615	COG2814	Major facilitator Superfamily
I633_19620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I633_19635	COG4890	Cyd operon protein YbgT
I633_19640	COG1294	oxidase, subunit
I633_19655	COG2204	response regulator
I633_19685	COG4319	ketosteroid isomerase
I633_19710	COG2375	cellular response to nickel ion
I633_19715	COG3237	CsbD-like
I633_19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I633_19740	COG0596	Alpha beta hydrolase
I633_19760	COG3038	cytochrome b561
I633_19770	COG1252	NADH dehydrogenase
I633_19790	COG0583	DNA-binding transcription factor activity
I633_19795	COG2067	long-chain fatty acid transport protein
I633_19800	COG2130	NADP-dependent
I633_19805	COG4251	negative regulation of phosphorylation
I633_19805	COG3706	GGDEF domain
I633_19805	COG2203	Gaf domain
I633_19805	COG5001	Diguanylate cyclase
I633_19810	COG2205	protein histidine kinase activity
I633_19810	COG0784	Response regulator, receiver
I633_19830	COG4372	Transposase
I633_19835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I633_19850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_19855	COG2181	nitrate reductase activity
I633_19860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I633_19865	COG1140	nitrate reductase beta subunit
I633_19870	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I633_19880	COG3850	Histidine kinase
I633_19890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I633_19905	COG2197	response regulator
I633_19915	COG2832	Protein of unknown function (DUF454)
I633_19925	COG0314	molybdopterin synthase activity
I633_19930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I633_19935	COG0315	cyclic pyranopterin monophosphate synthase activity
I633_19940	COG0521	Mo-molybdopterin cofactor biosynthetic process
I633_19945	COG0746	molybdenum cofactor guanylyltransferase activity
I633_19950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I633_19975	COG3962	Belongs to the TPP enzyme family
I633_20000	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I633_20035	COG2223	nitrite transmembrane transporter activity
I633_20040	COG0515	serine threonine protein kinase
I633_20050	COG1136	(ABC) transporter
I633_20080	COG1349	DNA-binding transcription factor activity
I633_20085	COG0673	inositol 2-dehydrogenase activity
I633_20100	COG0697	spore germination
I633_20105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I633_20110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I633_20115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I633_20120	COG1166	arginine decarboxylase activity
I633_20130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I633_20135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I633_20200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I633_20210	COG0109	protoheme IX farnesyltransferase activity
I633_20230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I633_20305	COG4232	protein-disulfide reductase activity
I633_20310	COG0739	heme binding
I633_20315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I633_20405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I633_20410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I633_20440	COG0151	Belongs to the GarS family
I633_20465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I633_20470	COG3954	Phosphoribulokinase
I633_20510	COG1501	Belongs to the glycosyl hydrolase 31 family
I633_20540	COG3031	protein transport across the cell outer membrane
I633_20550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I633_20555	COG1459	type II secretion system
I633_20560	COG2165	general secretion pathway protein
I633_20565	COG2165	general secretion pathway protein
I633_20570	COG2165	general secretion pathway protein
I633_20575	COG4795	General secretion pathway protein
I633_20590	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I633_20605	COG3344	reverse transcriptase
I633_20615	COG4667	esterase of the alpha-beta hydrolase superfamily
I633_20620	COG1012	belongs to the aldehyde dehydrogenase family
I633_20630	COG1011	Hydrolase
I633_20635	COG0494	nUDIX hydrolase
I633_20640	COG1218	3'(2'),5'-bisphosphate nucleotidase
I633_20655	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I633_20665	COG3089	Belongs to the UPF0270 family
I633_20670	COG0429	hydrolase of the alpha beta-hydrolase fold
I633_20705	COG2900	Belongs to the SlyX family
I633_20715	COG0545	Peptidyl-prolyl cis-trans isomerase
I633_20725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I633_20730	COG2183	response to ionizing radiation
I633_20755	COG2207	Transcriptional regulator
I633_20755	COG1609	Transcriptional regulator
I633_20760	COG2211	Major facilitator Superfamily
I633_20775	COG3693	PFAM glycoside hydrolase, family 10
I633_20780	COG0667	Aldo Keto reductase
I633_20785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I633_20790	COG2115	Belongs to the xylose isomerase family
I633_20795	COG1070	Carbohydrate kinase
I633_20820	COG0477	Major facilitator Superfamily
I633_20865	COG0596	Alpha beta hydrolase
I633_20870	COG1040	competence protein
I633_20895	COG1794	racemase activity, acting on amino acids and derivatives
I633_20915	COG1649	PFAM Uncharacterised BCR, COG1649
I633_20915	COG0726	polysaccharide deacetylase
I633_20925	COG1999	signal sequence binding
I633_20930	COG0109	protoheme IX farnesyltransferase activity
I633_20935	COG1612	heme a metabolic process
I633_20975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I633_20980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I633_21000	COG0129	dihydroxy-acid dehydratase activity
I633_21010	COG0606	chelatase, subunit chli
I633_21015	COG0583	DNA-binding transcription factor activity
I633_21080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I633_21090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I633_21115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I633_21165	COG0425	Belongs to the sulfur carrier protein TusA family
I633_21185	COG1561	YicC-like family, N-terminal region
I633_21260	COG3645	SOS response
I633_21360	COG2723	6-phospho-beta-galactosidase activity
I633_21365	COG2211	Major facilitator Superfamily
I633_21370	COG1609	Transcriptional regulator
I633_21385	COG2199	diguanylate cyclase activity
I633_21385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I633_21415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I633_21440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I633_21445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I633_21465	COG1475	DNA binding
I633_21470	COG1192	Involved in chromosome partitioning
I633_21495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I633_21515	COG0706	membrane insertase activity
I633_21520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I633_21525	COG0594	ribonuclease P activity
I633_21530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I633_21701	COG2814	Major facilitator Superfamily
I633_21731	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I633_21761	COG4829	muconolactone delta-isomerase
I633_21821	COG0596	Alpha beta hydrolase
I633_21826	COG3039	Transposase
I633_22021	COG2826	transposase and inactivated derivatives, IS30 family
I633_22041	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I633_22101	COG1988	membrane-bound metal-dependent
I633_22136	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I633_22276	COG0633	Ferredoxin
I633_22351	COG4974	Belongs to the 'phage' integrase family
I633_22356	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I633_22361	COG1061	Type III restriction enzyme res subunit
I633_22386	COG1061	Type III restriction enzyme res subunit
I633_22391	COG1002	Type II restriction enzyme, methylase subunits
I633_22431	COG2201	protein-glutamate methylesterase activity
I633_22436	COG1002	Type II restriction enzyme, methylase subunits
I633_22446	COG3152	Membrane
I633_22491	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I633_22626	COG0629	single-stranded DNA binding
I633_22831	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I633_22941	COG3135	benzoate transporter
I633_22946	COG1028	Short-chain dehydrogenase reductase Sdr