locus-tag	class	description
BM523_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM523_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM523_00025	COG0187	DNA topoisomerase II activity
BM523_00055	COG2818	Glycosylase
BM523_00065	COG3078	GTPase activator activity
BM523_00085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM523_00085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM523_00090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM523_00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM523_00100	COG0569	domain protein
BM523_00105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM523_00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM523_00110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM523_00125	COG0758	DNA mediated transformation
BM523_00140	COG0009	L-threonylcarbamoyladenylate synthase
BM523_00145	COG0408	coproporphyrinogen oxidase activity
BM523_00150	COG3047	cAMP biosynthetic process
BM523_00165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM523_00240	COG2234	aminopeptidase activity
BM523_00245	COG3562	capsule polysaccharide
BM523_00255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM523_00280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM523_00310	COG3642	lipopolysaccharide core region biosynthetic process
BM523_00315	COG0859	PFAM glycosyl transferase family 9
BM523_00345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM523_00360	COG3161	chorismate lyase activity
BM523_00365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM523_00385	COG0210	DNA helicase
BM523_00430	COG1959	2 iron, 2 sulfur cluster binding
BM523_00435	COG0730	response to heat
BM523_00465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM523_00470	COG4988	ABC transporter
BM523_00480	COG1271	oxidase subunit
BM523_00485	COG0425	Belongs to the sulfur carrier protein TusA family
BM523_00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM523_00495	COG0450	alkyl hydroperoxide reductase
BM523_00500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM523_00530	COG3727	T/G mismatch-specific endonuclease activity
BM523_00555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM523_00560	COG0556	nucleotide-excision repair
BM523_00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_00575	COG0842	Transport permease protein
BM523_00575	COG1129	ABC transporter
BM523_00580	COG0842	Transport permease protein
BM523_00590	COG4771	TonB-dependent receptor
BM523_00605	COG0583	DNA-binding transcription factor activity
BM523_00615	COG3106	COG3106 Predicted ATPase
BM523_00630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM523_00650	COG0352	thiamine-phosphate diphosphorylase activity
BM523_00660	COG3071	HemY protein
BM523_00665	COG2959	enzyme of heme biosynthesis
BM523_00675	COG0181	hydroxymethylbilane synthase activity
BM523_00680	COG0745	RESPONSE REGULATOR receiver
BM523_00680	COG3706	GGDEF domain
BM523_00690	COG0194	GDP metabolic process
BM523_00700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM523_00710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM523_00715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM523_00725	COG0678	peroxiredoxin activity
BM523_00740	COG1178	ABC-type Fe3 transport system permease component
BM523_00745	COG3842	ATPase activity
BM523_00750	COG0668	transmembrane transport
BM523_00755	COG2081	HI0933 family
BM523_00765	COG2200	EAL domain
BM523_00770	COG0583	DNA-binding transcription factor activity
BM523_00780	COG2076	Multidrug Resistance protein
BM523_00795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_00810	COG0427	acetyl-CoA hydrolase
BM523_00815	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM523_00830	COG0840	transmembrane signaling receptor activity
BM523_00840	COG3064	Membrane
BM523_00850	COG5002	protein histidine kinase activity
BM523_00850	COG5001	Diguanylate cyclase
BM523_00865	COG0514	ATP-dependent DNA helicase (RecQ)
BM523_00870	COG2239	Acts as a magnesium transporter
BM523_00875	COG2962	Rard protein
BM523_00880	COG0745	RESPONSE REGULATOR receiver
BM523_00880	COG3706	GGDEF domain
BM523_00885	COG0210	DNA helicase
BM523_00895	COG1011	Hydrolase
BM523_00910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM523_00915	COG0019	diaminopimelate decarboxylase activity
BM523_00945	COG0163	prenyltransferase activity
BM523_00950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM523_00960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM523_00980	COG1077	Cell shape determining protein MreB Mrl
BM523_00995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM523_01000	COG2814	Major facilitator Superfamily
BM523_01005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM523_01030	COG1085	galactose-1-phosphate uridylyltransferase
BM523_01035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM523_01045	COG0629	single-stranded DNA binding
BM523_01070	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM523_01095	COG1349	DNA-binding transcription factor activity
BM523_01140	COG3267	Type II secretory pathway component ExeA
BM523_01140	COG3409	Peptidoglycan-binding domain 1 protein
BM523_01150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM523_01155	COG1459	type II secretion system
BM523_01200	COG1077	Cell shape determining protein MreB Mrl
BM523_01205	COG1792	Involved in formation and maintenance of cell shape
BM523_01210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM523_01220	COG1530	ribonuclease E activity
BM523_01230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM523_01235	COG0312	modulator of DNA gyrase
BM523_01240	COG3028	Belongs to the UPF0307 family
BM523_01245	COG0312	modulator of DNA gyrase
BM523_01260	COG0745	RESPONSE REGULATOR receiver
BM523_01265	COG4191	Histidine kinase
BM523_01265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_01270	COG0297	glycogen (starch) synthase activity
BM523_01280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM523_01285	COG0596	Alpha beta hydrolase
BM523_01325	COG2814	Major facilitator Superfamily
BM523_01335	COG0745	RESPONSE REGULATOR receiver
BM523_01345	COG0835	chemotaxis
BM523_01360	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM523_01375	COG0745	RESPONSE REGULATOR receiver
BM523_01380	COG2198	Histidine kinase
BM523_01380	COG0643	Histidine kinase
BM523_01385	COG0835	chemotaxis
BM523_01405	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM523_01455	COG0546	phosphoglycolate phosphatase activity
BM523_01480	COG0673	inositol 2-dehydrogenase activity
BM523_01490	COG2211	Major facilitator Superfamily
BM523_01495	COG1082	Xylose isomerase domain protein TIM barrel
BM523_01515	COG1454	alcohol dehydrogenase
BM523_01590	COG0089	rRNA binding
BM523_01600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM523_01610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM523_01625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM523_01630	COG0438	transferase activity, transferring glycosyl groups
BM523_01640	COG1519	Transferase
BM523_01660	COG0840	transmembrane signaling receptor activity
BM523_01675	COG0788	formyltetrahydrofolate deformylase activity
BM523_01685	COG1643	Atp-dependent helicase
BM523_01690	COG2951	lytic endotransglycosylase activity
BM523_01695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM523_01705	COG2354	Protein conserved in bacteria
BM523_01715	COG4977	sequence-specific DNA binding
BM523_01730	COG0004	ammonium transporteR
BM523_01735	COG0405	Gamma-glutamyltransferase
BM523_01740	COG2837	iron assimilation
BM523_01755	COG0540	Belongs to the ATCase OTCase family
BM523_01780	COG4999	Histidine kinase
BM523_01780	COG3437	response regulator, receiver
BM523_01780	COG3850	Histidine kinase
BM523_01780	COG2205	protein histidine kinase activity
BM523_01795	COG5001	Diguanylate cyclase
BM523_01795	COG3300	MHYT domain
BM523_01805	COG1012	belongs to the aldehyde dehydrogenase family
BM523_01815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM523_01830	COG0180	Tryptophanyl-tRNA synthetase
BM523_01835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM523_01855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM523_01865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM523_01900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM523_01905	COG0281	malic enzyme
BM523_01915	COG0625	glutathione transferase activity
BM523_01925	COG0753	catalase activity
BM523_01950	COG3300	MHYT domain
BM523_01950	COG5001	Diguanylate cyclase
BM523_01955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM523_01955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM523_01965	COG0137	argininosuccinate synthase activity
BM523_01985	COG1803	Methylglyoxal synthase
BM523_01995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BM523_02010	COG0745	RESPONSE REGULATOR receiver
BM523_02015	COG2205	protein histidine kinase activity
BM523_02020	COG2267	carboxylic ester hydrolase activity
BM523_02025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM523_02035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM523_02045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM523_02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM523_02055	COG4942	peptidase
BM523_02060	COG2861	carbohydrate metabolic process
BM523_02085	COG1162	GTPase activity
BM523_02090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM523_02120	COG0028	Belongs to the TPP enzyme family
BM523_02140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM523_02145	COG0805	protein transport
BM523_02155	COG0084	hydrolase, TatD family'
BM523_02160	COG5001	Diguanylate cyclase
BM523_02160	COG3706	GGDEF domain
BM523_02160	COG4251	negative regulation of phosphorylation
BM523_02160	COG2203	Gaf domain
BM523_02170	COG0248	Ppx GppA phosphatase
BM523_02175	COG0513	Belongs to the DEAD box helicase family
BM523_02180	COG3118	belongs to the thioredoxin family
BM523_02185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM523_02195	COG5002	protein histidine kinase activity
BM523_02195	COG0784	Response regulator, receiver
BM523_02200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BM523_02210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM523_02225	COG0783	Belongs to the Dps family
BM523_02230	COG2133	pyrroloquinoline quinone binding
BM523_02235	COG1506	peptidase
BM523_02235	COG4946	Tricorn protease homolog
BM523_02235	COG0823	Involved in the tonB-independent uptake of proteins
BM523_02245	COG3118	belongs to the thioredoxin family
BM523_02260	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM523_02270	COG1012	belongs to the aldehyde dehydrogenase family
BM523_02290	COG1757	Na H antiporter
BM523_02305	COG3876	Protein conserved in bacteria
BM523_02310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM523_02320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BM523_02330	COG0346	lactoylglutathione lyase activity
BM523_02355	COG2824	Alkylphosphonate utilization operon protein PhnA
BM523_02360	COG0454	-acetyltransferase
BM523_02380	COG3093	addiction module antidote protein HigA
BM523_02450	COG0183	Belongs to the thiolase family
BM523_02455	COG1024	Enoyl-CoA hydratase
BM523_02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM523_02465	COG0006	proline dipeptidase activity
BM523_02475	COG0142	geranyltranstransferase activity
BM523_02505	COG4942	peptidase
BM523_02505	COG1388	LysM domain
BM523_02510	COG1238	metal cluster binding
BM523_02520	COG0585	pseudouridine synthase activity
BM523_02525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM523_02535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM523_02545	COG0840	transmembrane signaling receptor activity
BM523_02580	COG0494	nUDIX hydrolase
BM523_02585	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM523_02590	COG0730	response to heat
BM523_02595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM523_02600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM523_02605	COG2201	protein-glutamate methylesterase activity
BM523_02610	COG3706	GGDEF domain
BM523_02610	COG0745	RESPONSE REGULATOR receiver
BM523_02635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM523_02650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM523_02660	COG1648	precorrin-2 dehydrogenase activity
BM523_02660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM523_02665	COG0513	Belongs to the DEAD box helicase family
BM523_02680	COG1538	Outer membrane efflux protein
BM523_02685	COG0494	nUDIX hydrolase
BM523_02695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM523_02700	COG3150	esterase
BM523_02705	COG0187	DNA topoisomerase II activity
BM523_02715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM523_02740	COG1509	lysine 2,3-aminomutase activity
BM523_02750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM523_02765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM523_02770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM523_02785	COG0271	Belongs to the BolA IbaG family
BM523_02790	COG0671	phosphoesterase, PA-phosphatase related
BM523_02800	COG3707	response regulator
BM523_02815	COG0659	secondary active sulfate transmembrane transporter activity
BM523_02820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM523_02830	COG0243	molybdopterin cofactor binding
BM523_02835	COG1648	precorrin-2 dehydrogenase activity
BM523_02835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM523_02840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM523_02850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM523_02850	COG1116	anion transmembrane transporter activity
BM523_02860	COG1116	anion transmembrane transporter activity
BM523_02875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM523_02880	COG4206	TonB-dependent receptor
BM523_02885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM523_02890	COG0348	domain, Protein
BM523_02905	COG1960	acyl-CoA dehydrogenase activity
BM523_02910	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_02920	COG4948	Mandelate Racemase Muconate Lactonizing
BM523_02935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_02940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM523_02960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM523_02965	COG0358	DNA primase activity
BM523_02970	COG1610	YqeY-like protein
BM523_02990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM523_02995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM523_03010	COG0537	adenosine 5'-monophosphoramidase activity
BM523_03025	COG3135	benzoate transporter
BM523_03030	COG1396	sequence-specific DNA binding
BM523_03035	COG2974	May be involved in recombination
BM523_03040	COG4191	Histidine kinase
BM523_03040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_03045	COG0745	RESPONSE REGULATOR receiver
BM523_03050	COG5002	protein histidine kinase activity
BM523_03075	COG0811	peptide transport
BM523_03080	COG0811	peptide transport
BM523_03085	COG0848	biopolymer transport protein
BM523_03090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM523_03100	COG3437	response regulator, receiver
BM523_03110	COG0318	PFAM AMP-dependent synthetase and ligase
BM523_03120	COG2133	pyrroloquinoline quinone binding
BM523_03130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM523_03160	COG0527	aspartate kinase activity
BM523_03170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM523_03175	COG2967	ApaG domain
BM523_03185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM523_03190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM523_03195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM523_03200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM523_03210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM523_03230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM523_03245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM523_03250	COG3956	TIGRFAM MazG family protein
BM523_03275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM523_03280	COG0723	plastoquinol--plastocyanin reductase activity
BM523_03285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM523_03290	COG2857	Cytochrome c1
BM523_03295	COG0625	glutathione transferase activity
BM523_03300	COG2969	positive regulation of protein catabolic process
BM523_03315	COG0745	RESPONSE REGULATOR receiver
BM523_03320	COG2239	Acts as a magnesium transporter
BM523_03325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM523_03335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM523_03345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM523_03350	COG1137	ATPase activity
BM523_03355	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM523_03365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM523_03380	COG1127	ABC transporter
BM523_03385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM523_03390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM523_03395	COG2854	intermembrane phospholipid transfer
BM523_03405	COG5007	Belongs to the BolA IbaG family
BM523_03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM523_03420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM523_03430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM523_03465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM523_03480	COG4771	TonB-dependent receptor
BM523_03485	COG0697	spore germination
BM523_03490	COG2205	protein histidine kinase activity
BM523_03490	COG0784	Response regulator, receiver
BM523_03515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM523_03525	COG0126	phosphoglycerate kinase activity
BM523_03530	COG3588	fructose-bisphosphate aldolase
BM523_03540	COG1506	peptidase
BM523_03540	COG4946	Tricorn protease homolog
BM523_03540	COG0823	Involved in the tonB-independent uptake of proteins
BM523_03545	COG0248	Ppx GppA phosphatase
BM523_03550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM523_03560	COG0573	inorganic phosphate transmembrane transporter activity
BM523_03570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM523_03580	COG0306	phosphate transporter
BM523_03590	COG0583	DNA-binding transcription factor activity
BM523_03600	COG1272	protein, Hemolysin III
BM523_03605	COG1846	Transcriptional regulator
BM523_03610	COG1764	response to oxidative stress
BM523_03625	COG1739	Uncharacterized protein family UPF0029
BM523_03645	COG0583	DNA-binding transcription factor activity
BM523_03650	COG4989	oxidoreductase activity
BM523_03665	COG0420	3'-5' exonuclease activity
BM523_03670	COG0419	ATPase involved in DNA repair
BM523_03680	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BM523_03705	COG2188	Transcriptional regulator
BM523_03715	COG2986	histidine ammonia-lyase
BM523_03740	COG0488	(ABC) transporter
BM523_03765	COG0668	transmembrane transport
BM523_03825	COG1346	cytolysis
BM523_03855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM523_03865	COG0513	Belongs to the DEAD box helicase family
BM523_03875	COG3267	Type II secretory pathway component ExeA
BM523_03875	COG3409	Peptidoglycan-binding domain 1 protein
BM523_03890	COG0066	3-isopropylmalate dehydratase activity
BM523_03900	COG0473	3-isopropylmalate dehydrogenase activity
BM523_03905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM523_03930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM523_03945	COG4555	ABC transporter
BM523_03950	COG1668	transmembrane transport
BM523_03960	COG0745	RESPONSE REGULATOR receiver
BM523_03995	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM523_04000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM523_04005	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM523_04015	COG1138	Cytochrome C-type biogenesis protein
BM523_04020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM523_04035	COG2853	Lipoprotein
BM523_04040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM523_04050	COG3104	oligopeptide transport
BM523_04080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM523_04095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM523_04100	COG1596	polysaccharide export
BM523_04100	COG1555	photosystem II stabilization
BM523_04105	COG0473	3-isopropylmalate dehydrogenase activity
BM523_04120	COG1611	Belongs to the LOG family
BM523_04125	COG0745	RESPONSE REGULATOR receiver
BM523_04125	COG3706	GGDEF domain
BM523_04130	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM523_04130	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM523_04185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM523_04190	COG0024	Methionine aminopeptidase
BM523_04195	COG0052	Belongs to the universal ribosomal protein uS2 family
BM523_04205	COG0528	UMP kinase activity
BM523_04215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM523_04220	COG0575	Belongs to the CDS family
BM523_04245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM523_04265	COG0587	DNA-directed DNA polymerase activity
BM523_04270	COG0825	malonyl-CoA metabolic process
BM523_04275	COG0037	tRNA processing
BM523_04295	COG0590	tRNA wobble adenosine to inosine editing
BM523_04305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM523_04305	COG0047	phosphoribosylformylglycinamidine synthase activity
BM523_04310	COG2840	Smr protein MutS2
BM523_04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_04350	COG2197	response regulator
BM523_04390	COG0784	Response regulator, receiver
BM523_04390	COG0835	chemotaxis
BM523_04395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM523_04400	COG1815	bacterial-type flagellum-dependent cell motility
BM523_04405	COG1558	bacterial-type flagellum-dependent cell motility
BM523_04410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BM523_04415	COG1749	Flagellar hook protein flgE
BM523_04420	COG4787	bacterial-type flagellum-dependent cell motility
BM523_04425	COG4786	Flagellar basal body rod
BM523_04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM523_04440	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM523_04445	COG1256	bacterial-type flagellum assembly
BM523_04470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM523_04475	COG1334	flagellar protein FlaG
BM523_04480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM523_04500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM523_04505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM523_04520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM523_04545	COG2089	acid synthase
BM523_04560	COG1083	cytidylyl-transferase
BM523_04580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM523_04595	COG2089	acid synthase
BM523_04605	COG1083	cytidylyl-transferase
BM523_04610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM523_04615	COG1086	Polysaccharide biosynthesis protein
BM523_04620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM523_04630	COG2204	response regulator
BM523_04635	COG3852	Histidine kinase
BM523_04640	COG2204	response regulator
BM523_04645	COG1677	Flagellar hook-basal body complex protein FliE
BM523_04650	COG1766	The M ring may be actively involved in energy transduction
BM523_04655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM523_04705	COG1987	bacterial-type flagellum assembly
BM523_04720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM523_04730	COG0455	bacterial-type flagellum organization
BM523_04745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM523_04750	COG0643	Histidine kinase
BM523_04750	COG2198	Histidine kinase
BM523_04760	COG1192	Involved in chromosome partitioning
BM523_04770	COG0835	chemotaxis
BM523_04785	COG0646	methionine synthase
BM523_04785	COG1410	methionine synthase
BM523_04790	COG1410	methionine synthase
BM523_04790	COG0646	methionine synthase
BM523_04800	COG3123	guanosine phosphorylase activity
BM523_04810	COG0583	DNA-binding transcription factor activity
BM523_04815	COG0583	DNA-binding transcription factor activity
BM523_04825	COG0659	secondary active sulfate transmembrane transporter activity
BM523_04840	COG3590	peptidase
BM523_04850	COG2137	regulation of response to DNA damage stimulus
BM523_04855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM523_04885	COG0511	ligase activity, forming carbon-carbon bonds
BM523_04885	COG5016	pyruvate
BM523_04890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BM523_04895	COG4172	Belongs to the ABC transporter superfamily
BM523_04905	COG4171	peptide transport system, permease
BM523_04910	COG4168	peptide transport system, permease
BM523_04915	COG0747	negative chemotaxis
BM523_04920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM523_04925	COG1842	Phage shock protein A
BM523_04955	COG0625	glutathione transferase activity
BM523_04960	COG1522	sequence-specific DNA binding
BM523_05025	COG0811	peptide transport
BM523_05030	COG0811	peptide transport
BM523_05035	COG0848	biopolymer transport protein
BM523_05050	COG1444	tRNA N-acetyltransferase activity
BM523_05090	COG0456	acetyltransferase
BM523_05105	COG0583	DNA-binding transcription factor activity
BM523_05110	COG2814	Major facilitator Superfamily
BM523_05115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM523_05120	COG0656	L-ascorbic acid biosynthetic process
BM523_05130	COG0745	RESPONSE REGULATOR receiver
BM523_05130	COG3706	GGDEF domain
BM523_05160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM523_05205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM523_05210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM523_05215	COG0564	pseudouridine synthase activity
BM523_05225	COG0612	Peptidase, M16
BM523_05230	COG2918	glutathione biosynthetic process
BM523_05245	COG2840	Smr protein MutS2
BM523_05250	COG2890	protein-(glutamine-N5) methyltransferase activity
BM523_05265	COG2719	SpoVR family
BM523_05270	COG2718	Belongs to the UPF0229 family
BM523_05275	COG2766	serine protein kinase
BM523_05285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM523_05290	COG4771	TonB-dependent receptor
BM523_05315	COG0450	alkyl hydroperoxide reductase
BM523_05320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM523_05325	COG2885	chlorophyll binding
BM523_05330	COG0584	glycerophosphoryl diester phosphodiesterase
BM523_05335	COG0346	lactoylglutathione lyase activity
BM523_05340	COG1278	Cold shock
BM523_05355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM523_05360	COG4660	Part of a membrane complex involved in electron transport
BM523_05365	COG4659	FMN binding
BM523_05370	COG4658	electron transport chain
BM523_05375	COG4656	Part of a membrane complex involved in electron transport
BM523_05380	COG2878	Part of a membrane complex involved in electron transport
BM523_05400	COG0534	Mate efflux family protein
BM523_05405	COG0556	nucleotide-excision repair
BM523_05420	COG0602	queuosine metabolic process
BM523_05430	COG0367	asparagine synthase
BM523_05455	COG3273	potassium ion transport
BM523_05455	COG0471	metal ion transport
BM523_05470	COG0529	Catalyzes the synthesis of activated sulfate
BM523_05475	COG0175	sulfate reduction
BM523_05480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM523_05485	COG3706	GGDEF domain
BM523_05510	COG2304	oxidoreductase activity
BM523_05530	COG0714	Associated with various cellular activities
BM523_05540	COG1024	Enoyl-CoA hydratase
BM523_05540	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM523_05555	COG1025	Belongs to the peptidase M16 family
BM523_05560	COG2062	phosphohistidine phosphatase, SixA
BM523_05570	COG4536	flavin adenine dinucleotide binding
BM523_05575	COG4137	Cytochrome C assembly protein
BM523_05580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM523_05625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_05630	COG1132	(ABC) transporter
BM523_05645	COG0228	four-way junction DNA binding
BM523_05650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM523_05655	COG0336	Belongs to the RNA methyltransferase TrmD family
BM523_05660	COG0335	large ribosomal subunit rRNA binding
BM523_05665	COG2860	membrane
BM523_05675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM523_05680	COG1605	Chorismate mutase
BM523_05680	COG0287	Prephenate dehydrogenase
BM523_05685	COG1605	Chorismate mutase
BM523_05685	COG0077	Prephenate dehydratase
BM523_05695	COG0023	Translation Initiation Factor
BM523_05725	COG2205	protein histidine kinase activity
BM523_05735	COG2204	response regulator
BM523_05755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM523_05760	COG0494	nUDIX hydrolase
BM523_05765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM523_05775	COG2255	four-way junction helicase activity
BM523_05780	COG0824	Thioesterase
BM523_05785	COG0811	peptide transport
BM523_05800	COG0823	Involved in the tonB-independent uptake of proteins
BM523_05805	COG2885	chlorophyll binding
BM523_05810	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM523_05830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM523_05845	COG4667	esterase of the alpha-beta hydrolase superfamily
BM523_05850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM523_05865	COG0300	oxidoreductase activity
BM523_05870	COG3038	cytochrome b561
BM523_05900	COG0583	DNA-binding transcription factor activity
BM523_05905	COG1064	alcohol dehydrogenase
BM523_05910	COG1451	nucleotide metabolic process
BM523_05915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM523_05925	COG1309	transcriptional regulator
BM523_05930	COG4774	siderophore transport
BM523_05950	COG3706	GGDEF domain
BM523_05960	COG3008	intermembrane lipid transfer
BM523_05960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM523_05965	COG2995	paraquat-inducible protein a
BM523_05985	COG2207	Transcriptional regulator
BM523_05990	COG0017	Asparaginyl-tRNA synthetase
BM523_06005	COG0189	ligase activity
BM523_06035	COG0156	8-amino-7-oxononanoate synthase activity
BM523_06040	COG2226	methyltransferase
BM523_06050	COG3340	Belongs to the peptidase S51 family
BM523_06055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM523_06060	COG4139	cobalamin transport
BM523_06065	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BM523_06070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM523_06085	COG5265	(ABC) transporter
BM523_06090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM523_06100	COG0745	RESPONSE REGULATOR receiver
BM523_06120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM523_06155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM523_06170	COG2755	lipolytic protein G-D-S-L family
BM523_06175	COG4181	ATPase activity
BM523_06180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM523_06185	COG1090	epimerase
BM523_06190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM523_06195	COG0628	permease
BM523_06205	COG0745	RESPONSE REGULATOR receiver
BM523_06220	COG2350	Protein conserved in bacteria
BM523_06225	COG0159	tryptophan synthase activity
BM523_06235	COG0135	phosphoribosylanthranilate isomerase activity
BM523_06235	COG0134	indole-3-glycerol-phosphate synthase activity
BM523_06240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM523_06250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM523_06255	COG0613	PHP domain protein
BM523_06260	COG0009	L-threonylcarbamoyladenylate synthase
BM523_06265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BM523_06270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM523_06280	COG0656	L-ascorbic acid biosynthetic process
BM523_06285	COG0110	maltose O-acetyltransferase activity
BM523_06295	COG2733	membrane
BM523_06315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_06320	COG0500	methyltransferase
BM523_06325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM523_06330	COG0497	DNA recombination
BM523_06335	COG0783	Belongs to the Dps family
BM523_06345	COG1454	alcohol dehydrogenase
BM523_06350	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_06360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM523_06365	COG2610	gluconate transmembrane transporter activity
BM523_06380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_06380	COG2205	protein histidine kinase activity
BM523_06380	COG0784	Response regulator, receiver
BM523_06380	COG2198	Histidine kinase
BM523_06400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM523_06410	COG0484	heat shock protein binding
BM523_06415	COG3909	cytochrome
BM523_06435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM523_06440	COG0505	Belongs to the CarA family
BM523_06445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM523_06450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM523_06470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM523_06475	COG0280	phosphate acetyltransferase
BM523_06475	COG0857	belongs to the CobB CobQ family
BM523_06490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM523_06495	COG4535	Mg2 and Co2 transporter CorC
BM523_06505	COG1702	phosphate starvation-inducible protein PhoH
BM523_06515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM523_06545	COG1607	acyl-coa hydrolase
BM523_06550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM523_06560	COG1115	amino acid carrier protein
BM523_06605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM523_06610	COG0012	GTP binding
BM523_06625	COG1064	alcohol dehydrogenase
BM523_06640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM523_06650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM523_06655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM523_06660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM523_06670	COG2890	protein-(glutamine-N5) methyltransferase activity
BM523_06675	COG3437	response regulator, receiver
BM523_06675	COG0784	Response regulator, receiver
BM523_06680	COG3094	Invasion gene expression up-regulator, SirB
BM523_06695	COG0583	DNA-binding transcription factor activity
BM523_06705	COG2363	Small membrane protein
BM523_06720	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM523_06725	COG0515	serine threonine protein kinase
BM523_06730	COG2116	formate transmembrane transporter activity
BM523_06745	COG0714	Associated with various cellular activities
BM523_06750	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM523_06755	COG0033	Phosphoglucomutase
BM523_06760	COG0058	SHG alpha-glucan phosphorylase activity
BM523_06770	COG2988	succinylglutamate desuccinylase activity
BM523_06805	COG1393	Belongs to the ArsC family
BM523_06830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM523_06860	COG3300	MHYT domain
BM523_06860	COG5001	Diguanylate cyclase
BM523_06885	COG2249	NAD(P)H dehydrogenase (quinone) activity
BM523_06905	COG1733	regulation of RNA biosynthetic process
BM523_06910	COG3447	MASE1 domain protein
BM523_06910	COG5002	protein histidine kinase activity
BM523_06910	COG5001	Diguanylate cyclase
BM523_06920	COG0402	S-adenosylhomocysteine deaminase activity
BM523_06925	COG2351	hydroxyisourate hydrolase activity
BM523_06940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM523_06955	COG1309	transcriptional regulator
BM523_06970	COG2252	PERMEase
BM523_06975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM523_06990	COG4251	negative regulation of phosphorylation
BM523_06990	COG2203	Gaf domain
BM523_06990	COG5001	Diguanylate cyclase
BM523_06990	COG3706	GGDEF domain
BM523_06995	COG2205	protein histidine kinase activity
BM523_06995	COG0784	Response regulator, receiver
BM523_07005	COG2233	PERMEase
BM523_07020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM523_07025	COG0730	response to heat
BM523_07065	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_07080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM523_07100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM523_07110	COG1596	polysaccharide export
BM523_07115	COG0489	protein tyrosine kinase activity
BM523_07120	COG4464	protein tyrosine phosphatase activity
BM523_07155	COG0297	glycogen (starch) synthase activity
BM523_07210	COG0438	transferase activity, transferring glycosyl groups
BM523_07220	COG2755	lipolytic protein G-D-S-L family
BM523_07220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM523_07240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM523_07240	COG0072	phenylalanine-tRNA ligase activity
BM523_07265	COG1472	Belongs to the glycosyl hydrolase 3 family
BM523_07270	COG2096	Adenosyltransferase
BM523_07280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM523_07290	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM523_07315	COG0708	Exodeoxyribonuclease III
BM523_07350	COG2814	Major facilitator Superfamily
BM523_07390	COG1024	Enoyl-CoA hydratase
BM523_07395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM523_07400	COG1960	acyl-CoA dehydrogenase activity
BM523_07405	COG0789	Transcriptional regulator
BM523_07410	COG0183	Belongs to the thiolase family
BM523_07425	COG3706	GGDEF domain
BM523_07435	COG2925	Exonuclease
BM523_07485	COG1643	Atp-dependent helicase
BM523_07505	COG0604	alcohol dehydrogenase
BM523_07505	COG3321	synthase
BM523_07510	COG0328	RNA-DNA hybrid ribonuclease activity
BM523_07515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM523_07545	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM523_07555	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM523_07570	COG3724	N-succinylarginine dihydrolase activity
BM523_07580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM523_07595	COG0746	molybdenum cofactor guanylyltransferase activity
BM523_07600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BM523_07605	COG0243	molybdopterin cofactor binding
BM523_07615	COG0625	glutathione transferase activity
BM523_07630	COG2153	protein acetylation
BM523_07645	COG1530	ribonuclease E activity
BM523_07665	COG1399	metal-binding, possibly nucleic acid-binding protein
BM523_07675	COG0416	fatty acid biosynthetic process
BM523_07680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM523_07685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM523_07695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM523_07700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM523_07710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM523_07725	COG0084	hydrolase, TatD family'
BM523_07735	COG0702	epimerase
BM523_07740	COG3706	GGDEF domain
BM523_07740	COG0745	RESPONSE REGULATOR receiver
BM523_07760	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_07765	COG0596	Alpha beta hydrolase
BM523_07775	COG0183	Belongs to the thiolase family
BM523_07780	COG1960	acyl-CoA dehydrogenase activity
BM523_07800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM523_07810	COG0246	Mannitol dehydrogenase
BM523_07835	COG0668	transmembrane transport
BM523_07840	COG4771	TonB-dependent receptor
BM523_07870	COG3437	response regulator, receiver
BM523_07880	COG0195	Participates in both transcription termination and antitermination
BM523_07895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM523_07910	COG3300	MHYT domain
BM523_07910	COG5001	Diguanylate cyclase
BM523_07915	COG1187	pseudouridine synthase activity
BM523_07925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM523_07925	COG3153	acetyltransferase
BM523_07955	COG0450	alkyl hydroperoxide reductase
BM523_07995	COG1032	radical SAM domain protein
BM523_08010	COG4771	TonB-dependent receptor
BM523_08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM523_08025	COG4134	Bacterial extracellular solute-binding protein
BM523_08035	COG4136	ATPase activity
BM523_08040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM523_08060	COG3706	GGDEF domain
BM523_08060	COG4251	negative regulation of phosphorylation
BM523_08060	COG5001	Diguanylate cyclase
BM523_08060	COG2203	Gaf domain
BM523_08080	COG0583	DNA-binding transcription factor activity
BM523_08100	COG1131	(ABC) transporter
BM523_08115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM523_08120	COG0385	Bile acid
BM523_08180	COG1902	pentaerythritol trinitrate reductase activity
BM523_08190	COG2867	negative regulation of translational initiation
BM523_08195	COG2914	Belongs to the UPF0125 (RnfH) family
BM523_08205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM523_08210	COG4771	TonB-dependent receptor
BM523_08215	COG0457	Tetratricopeptide repeat
BM523_08230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM523_08230	COG0574	Belongs to the PEP-utilizing enzyme family
BM523_08265	COG2850	peptidyl-arginine hydroxylation
BM523_08275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM523_08280	COG2915	High frequency lysogenization protein hflD homolog
BM523_08285	COG0482	sulfurtransferase activity
BM523_08290	COG1187	pseudouridine synthase activity
BM523_08300	COG1278	Cold shock
BM523_08305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM523_08310	COG0542	response to heat
BM523_08315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM523_08320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM523_08325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM523_08330	COG0492	ferredoxin-NADP+ reductase activity
BM523_08335	COG3092	negative regulation of chromosome organization
BM523_08340	COG3091	SprT-like family
BM523_08345	COG0616	signal peptide processing
BM523_08360	COG0778	Nitroreductase
BM523_08370	COG0252	asparaginase activity
BM523_08375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM523_08380	COG0321	lipoyl(octanoyl) transferase activity
BM523_08385	COG2921	Belongs to the UPF0250 family
BM523_08390	COG1686	Belongs to the peptidase S11 family
BM523_08395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM523_08400	COG0772	Belongs to the SEDS family
BM523_08405	COG0768	penicillin binding
BM523_08410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM523_08415	COG0799	negative regulation of ribosome biogenesis
BM523_08425	COG1466	dna polymerase III delta subunit
BM523_08430	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BM523_08435	COG0495	leucyl-tRNA aminoacylation
BM523_08445	COG1067	ATP-dependent peptidase activity
BM523_08450	COG0596	Alpha beta hydrolase
BM523_08455	COG3706	GGDEF domain
BM523_08465	COG1534	Rna-binding protein
BM523_08470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM523_08475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM523_08480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM523_08485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM523_08490	COG0149	triose-phosphate isomerase activity
BM523_08495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM523_08525	COG1597	lipid kinase activity
BM523_08525	COG1803	Methylglyoxal synthase
BM523_08535	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_08540	COG0561	phosphatase activity
BM523_08555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM523_08580	COG1185	polyribonucleotide nucleotidyltransferase activity
BM523_08725	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BM523_08730	COG1196	nuclear chromosome segregation
BM523_08740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM523_08755	COG1132	(ABC) transporter
BM523_08760	COG1663	tetraacyldisaccharide 4'-kinase activity
BM523_08795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM523_08800	COG0435	Glutathione S-transferase
BM523_08805	COG1741	Belongs to the pirin family
BM523_08810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM523_08820	COG0372	Belongs to the citrate synthase family
BM523_08825	COG2009	succinate dehydrogenase
BM523_08830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM523_08835	COG1053	succinate dehydrogenase
BM523_08840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM523_08845	COG0567	Dehydrogenase, E1 component
BM523_08850	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM523_08895	COG4667	esterase of the alpha-beta hydrolase superfamily
BM523_08915	COG0366	Alpha amylase catalytic
BM523_08940	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_08945	COG2267	carboxylic ester hydrolase activity
BM523_08955	COG0616	signal peptide processing
BM523_08975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM523_08980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM523_08985	COG0386	Belongs to the glutathione peroxidase family
BM523_08990	COG2084	Dehydrogenase
BM523_09000	COG1960	acyl-CoA dehydrogenase activity
BM523_09005	COG1024	Enoyl-CoA hydratase
BM523_09010	COG2226	methyltransferase
BM523_09015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM523_09020	COG3083	sulfuric ester hydrolase activity
BM523_09025	COG3082	Protein of unknown function (DUF1414)
BM523_09030	COG3081	Nucleoid-associated protein
BM523_09060	COG3275	phosphorelay sensor kinase activity
BM523_09065	COG3279	Response regulator of the LytR AlgR family
BM523_09070	COG0205	6-phosphofructokinase activity
BM523_09080	COG0789	Transcriptional regulator
BM523_09130	COG2205	protein histidine kinase activity
BM523_09130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_09150	COG0513	Belongs to the DEAD box helicase family
BM523_09160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM523_09165	COG0583	DNA-binding transcription factor activity
BM523_09185	COG1760	l-serine dehydratase
BM523_09205	COG1322	Protein conserved in bacteria
BM523_09210	COG1404	Belongs to the peptidase S8 family
BM523_09215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM523_09220	COG0022	dehydrogenase e1 component
BM523_09230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM523_09235	COG0515	serine threonine protein kinase
BM523_09240	COG1946	Acyl-CoA thioesterase
BM523_09250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM523_09260	COG1956	GAF domain-containing protein
BM523_09275	COG0793	Belongs to the peptidase S41A family
BM523_09280	COG0733	neurotransmitter:sodium symporter activity
BM523_09290	COG0308	aminopeptidase N
BM523_09320	COG2902	Dehydrogenase
BM523_09325	COG0167	dihydroorotate dehydrogenase activity
BM523_09350	COG3130	regulation of translation
BM523_09355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM523_09365	COG0415	Belongs to the DNA photolyase family
BM523_09370	COG0415	Belongs to the DNA photolyase family
BM523_09375	COG0415	Belongs to the DNA photolyase family
BM523_09380	COG3046	protein related to deoxyribodipyrimidine photolyase
BM523_09395	COG4264	IucA IucC family
BM523_09400	COG0318	PFAM AMP-dependent synthetase and ligase
BM523_09405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM523_09410	COG1082	Xylose isomerase domain protein TIM barrel
BM523_09440	COG4974	Belongs to the 'phage' integrase family
BM523_09450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM523_09455	COG0589	response to stress
BM523_09465	COG0069	glutamate synthase activity
BM523_09480	COG2193	ferroxidase activity
BM523_09490	COG3278	Belongs to the heme-copper respiratory oxidase family
BM523_09505	COG2010	Cytochrome c
BM523_09530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM523_09535	COG0589	response to stress
BM523_09540	COG0037	tRNA processing
BM523_09545	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM523_09565	COG1280	lysine exporter protein (LysE YggA)
BM523_09570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BM523_09575	COG2897	thiosulfate sulfurtransferase activity
BM523_09580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM523_09605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM523_09610	COG0322	excinuclease ABC activity
BM523_09615	COG2197	response regulator
BM523_09620	COG0436	Aminotransferase
BM523_09625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM523_09635	COG0670	Belongs to the BI1 family
BM523_09640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM523_09655	COG2920	part of a sulfur-relay system
BM523_09685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM523_09695	COG1674	ftsk spoiiie
BM523_09695	COG0531	amino acid
BM523_09705	COG0686	Belongs to the AlaDH PNT family
BM523_09710	COG0284	orotidine-5'-phosphate decarboxylase activity
BM523_09715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM523_09730	COG0776	regulation of translation
BM523_09735	COG0539	negative regulation of cytoplasmic translation
BM523_09740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM523_09745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM523_09750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM523_09760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM523_09765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM523_09770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM523_09775	COG0633	Ferredoxin
BM523_09805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM523_09810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM523_09820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM523_09830	COG4783	chaperone-mediated protein folding
BM523_09840	COG1393	Belongs to the ArsC family
BM523_09855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM523_09870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM523_09880	COG1960	acyl-CoA dehydrogenase activity
BM523_09905	COG0572	uridine kinase
BM523_09910	COG3769	mannosylglycerate metabolic process
BM523_09915	COG1215	transferase activity, transferring glycosyl groups
BM523_09920	COG0366	Alpha amylase catalytic
BM523_09930	COG0303	'Molybdopterin
BM523_09935	COG0534	Mate efflux family protein
BM523_09950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM523_09955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM523_10015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM523_10140	COG0405	Gamma-glutamyltransferase
BM523_10145	COG1024	Enoyl-CoA hydratase
BM523_10190	COG1448	Aminotransferase
BM523_10205	COG1671	Belongs to the UPF0178 family
BM523_10210	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_10215	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_10220	COG1960	acyl-CoA dehydrogenase activity
BM523_10225	COG0662	Cupin 2, conserved barrel domain protein
BM523_10225	COG2207	Transcriptional regulator
BM523_10230	COG4771	TonB-dependent receptor
BM523_10240	COG1505	serine-type exopeptidase activity
BM523_10250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_10280	COG0596	Alpha beta hydrolase
BM523_10290	COG0716	FMN binding
BM523_10300	COG0735	belongs to the Fur family
BM523_10310	COG1984	allophanate hydrolase subunit 2
BM523_10315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BM523_10320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM523_10325	COG2996	Protein conserved in bacteria
BM523_10330	COG1765	OsmC-like protein
BM523_10335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_10345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM523_10360	COG0436	Aminotransferase
BM523_10365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM523_10370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM523_10395	COG3012	SEC-C Motif Domain Protein
BM523_10400	COG5002	protein histidine kinase activity
BM523_10400	COG5001	Diguanylate cyclase
BM523_10400	COG3447	MASE1 domain protein
BM523_10405	COG0366	Alpha amylase catalytic
BM523_10415	COG0604	alcohol dehydrogenase
BM523_10425	COG1960	acyl-CoA dehydrogenase activity
BM523_10435	COG4771	TonB-dependent receptor
BM523_10455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM523_10460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM523_10480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM523_10490	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM523_10495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM523_10505	COG2161	toxin-antitoxin pair type II binding
BM523_10510	COG4115	mRNA cleavage
BM523_10530	COG3268	Saccharopine dehydrogenase
BM523_10535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM523_10555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BM523_10560	COG4206	TonB-dependent receptor
BM523_10570	COG5006	permease, DMT superfamily
BM523_10585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM523_10590	COG1074	ATP-dependent DNA helicase activity
BM523_10595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM523_10605	COG1022	Amp-dependent synthetase and ligase
BM523_10610	COG5001	Diguanylate cyclase
BM523_10630	COG0583	DNA-binding transcription factor activity
BM523_10645	COG0640	Transcriptional regulator
BM523_10665	COG2204	response regulator
BM523_10675	COG4251	negative regulation of phosphorylation
BM523_10680	COG0784	Response regulator, receiver
BM523_10685	COG2205	protein histidine kinase activity
BM523_10685	COG0784	Response regulator, receiver
BM523_10710	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM523_10735	COG3139	Protein of unknown function (DUF1315)
BM523_10750	COG1115	amino acid carrier protein
BM523_10755	COG2866	Carboxypeptidase
BM523_10775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM523_10785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM523_10790	COG1640	4-alpha-glucanotransferase
BM523_10795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM523_10800	COG0676	glucose-6-phosphate 1-epimerase activity
BM523_10805	COG0800	Aldolase
BM523_10815	COG0129	dihydroxy-acid dehydratase activity
BM523_10825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM523_10830	COG1737	Transcriptional regulator
BM523_10835	COG0469	pyruvate kinase activity
BM523_10840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM523_10855	COG2823	Periplasmic or secreted lipoprotein
BM523_10885	COG3665	Urea carboxylase-associated protein
BM523_10905	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_10920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BM523_10935	COG2721	sulfolactate sulfo-lyase activity
BM523_10940	COG1904	glucuronate isomerase
BM523_10945	COG0246	Mannitol dehydrogenase
BM523_10950	COG0800	Aldolase
BM523_10955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM523_10970	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BM523_10995	COG2356	endonuclease I
BM523_11000	COG0840	transmembrane signaling receptor activity
BM523_11015	COG0583	DNA-binding transcription factor activity
BM523_11020	COG1979	alcohol dehydrogenase
BM523_11025	COG5001	Diguanylate cyclase
BM523_11035	COG0784	Response regulator, receiver
BM523_11035	COG3437	response regulator, receiver
BM523_11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_11040	COG4191	Histidine kinase
BM523_11055	COG0471	metal ion transport
BM523_11065	COG0489	protein tyrosine kinase activity
BM523_11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM523_11070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM523_11075	COG0668	transmembrane transport
BM523_11080	COG2226	methyltransferase
BM523_11085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM523_11090	COG1388	LysM domain
BM523_11090	COG0741	lytic transglycosylase activity
BM523_11110	COG0215	cysteine-tRNA ligase activity
BM523_11115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM523_11120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM523_11130	COG2268	Band 7 protein
BM523_11145	COG1733	regulation of RNA biosynthetic process
BM523_11150	COG0604	alcohol dehydrogenase
BM523_11160	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_11165	COG0753	catalase activity
BM523_11170	COG0604	alcohol dehydrogenase
BM523_11175	COG0583	DNA-binding transcription factor activity
BM523_11210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM523_11215	COG1286	toxin biosynthetic process
BM523_11220	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM523_11225	COG0285	dihydrofolate synthase activity
BM523_11245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM523_11250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM523_11270	COG2080	2 iron, 2 sulfur cluster binding
BM523_11290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM523_11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM523_11305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM523_11340	COG0789	Transcriptional regulator
BM523_11345	COG0604	alcohol dehydrogenase
BM523_11370	COG1119	ATPase activity
BM523_11375	COG2031	fatty acid transporter
BM523_11380	COG5002	protein histidine kinase activity
BM523_11380	COG0784	Response regulator, receiver
BM523_11380	COG2205	protein histidine kinase activity
BM523_11390	COG0612	Peptidase, M16
BM523_11405	COG3101	peptidyl-lysine hydroxylation
BM523_11430	COG1902	pentaerythritol trinitrate reductase activity
BM523_11430	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM523_11455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM523_11465	COG4399	Belongs to the UPF0754 family
BM523_11490	COG1770	oligopeptidase
BM523_11495	COG2186	Transcriptional regulator
BM523_11505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM523_11510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM523_11520	COG2983	Belongs to the UPF0260 family
BM523_11525	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM523_11540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM523_11545	COG0318	PFAM AMP-dependent synthetase and ligase
BM523_11550	COG2267	carboxylic ester hydrolase activity
BM523_11565	COG1214	PFAM Peptidase M22, glycoprotease
BM523_11570	COG1199	ATP-dependent helicase activity
BM523_11620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM523_11625	COG4771	TonB-dependent receptor
BM523_11635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM523_11640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM523_11645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM523_11650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM523_11650	COG0131	Imidazoleglycerol-phosphate dehydratase
BM523_11655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM523_11670	COG0140	phosphoribosyl-ATP diphosphatase activity
BM523_11670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM523_11675	COG2116	formate transmembrane transporter activity
BM523_11715	COG0326	Molecular chaperone. Has ATPase activity
BM523_11720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM523_11800	COG0582	viral genome integration into host DNA
BM523_11820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM523_11825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM523_11835	COG3220	belongs to the UPF0276 family
BM523_11845	COG0577	efflux transmembrane transporter activity
BM523_11845	COG1136	(ABC) transporter
BM523_11855	COG4251	negative regulation of phosphorylation
BM523_11855	COG5001	Diguanylate cyclase
BM523_11855	COG2203	Gaf domain
BM523_11855	COG3706	GGDEF domain
BM523_11885	COG1183	phosphatidylcholine synthase activity
BM523_11905	COG0277	FAD linked oxidase domain protein
BM523_11910	COG0542	response to heat
BM523_11920	COG0564	pseudouridine synthase activity
BM523_11935	COG1595	DNA-templated transcription, initiation
BM523_11950	COG4221	oxidoreductase activity
BM523_11965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM523_11975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM523_11985	COG0142	geranyltranstransferase activity
BM523_11995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM523_12000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM523_12010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM523_12025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM523_12025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM523_12045	COG0488	(ABC) transporter
BM523_12055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM523_12065	COG0560	Phosphoserine phosphatase
BM523_12075	COG0084	hydrolase, TatD family'
BM523_12090	COG0571	ribonuclease III activity
BM523_12095	COG0681	Belongs to the peptidase S26 family
BM523_12120	COG1595	DNA-templated transcription, initiation
BM523_12125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM523_12140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM523_12220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM523_12225	COG1047	Peptidyl-prolyl cis-trans
BM523_12235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM523_12240	COG0196	riboflavin kinase activity
BM523_12245	COG0728	peptidoglycan biosynthetic process
BM523_12250	COG0268	Binds directly to 16S ribosomal RNA
BM523_12265	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_12270	COG0385	Bile acid
BM523_12275	COG0583	DNA-binding transcription factor activity
BM523_12300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM523_12305	COG0776	regulation of translation
BM523_12310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM523_12315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM523_12320	COG0740	serine-type endopeptidase activity
BM523_12325	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM523_12365	COG1720	tRNA m6t6A37 methyltransferase activity
BM523_12375	COG1234	tRNA 3'-trailer cleavage
BM523_12385	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM523_12400	COG0516	GMP reductase activity
BM523_12400	COG0517	IMP dehydrogenase activity
BM523_12405	COG1570	exodeoxyribonuclease VII activity
BM523_12425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM523_12430	COG2976	Protein conserved in bacteria
BM523_12455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM523_12465	COG2166	iron-sulfur cluster assembly
BM523_12480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM523_12485	COG0719	Fe-S assembly protein
BM523_12490	COG0396	ATPase activity
BM523_12495	COG0719	Fe-S assembly protein
BM523_12500	COG1104	cysteine desulfurase activity
BM523_12505	COG1959	2 iron, 2 sulfur cluster binding
BM523_12510	COG2072	flavoprotein involved in K transport
BM523_12515	COG1045	serine acetyltransferase
BM523_12520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM523_12525	COG0483	inositol monophosphate 1-phosphatase activity
BM523_12540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM523_12545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM523_12550	COG1862	Preprotein translocase
BM523_12555	COG0343	queuine tRNA-ribosyltransferase activity
BM523_12575	COG1842	Phage shock protein A
BM523_12580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM523_12600	COG0754	glutathionylspermidine amidase activity
BM523_12630	COG2066	Belongs to the glutaminase family
BM523_12635	COG1785	Belongs to the alkaline phosphatase family
BM523_12670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM523_12705	COG2171	N-acyltransferase activity
BM523_12725	COG0438	transferase activity, transferring glycosyl groups
BM523_12740	COG0367	asparagine synthase
BM523_12745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM523_12745	COG2755	lipolytic protein G-D-S-L family
BM523_12750	COG0438	transferase activity, transferring glycosyl groups
BM523_12775	COG2244	polysaccharide biosynthetic process
BM523_12835	COG0489	protein tyrosine kinase activity
BM523_12845	COG3409	Peptidoglycan-binding domain 1 protein
BM523_12845	COG3267	Type II secretory pathway component ExeA
BM523_12850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM523_12850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM523_12880	COG1560	Kdo2-lipid A biosynthetic process
BM523_12895	COG1960	acyl-CoA dehydrogenase activity
BM523_12910	COG3300	MHYT domain
BM523_12910	COG5001	Diguanylate cyclase
BM523_12915	COG1435	thymidine kinase activity
BM523_12925	COG1609	Transcriptional regulator
BM523_12930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM523_12960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM523_12965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM523_12970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM523_12970	COG1024	Enoyl-CoA hydratase
BM523_12985	COG1012	belongs to the aldehyde dehydrogenase family
BM523_13005	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM523_13010	COG0789	Transcriptional regulator
BM523_13040	COG1960	acyl-CoA dehydrogenase activity
BM523_13060	COG0745	RESPONSE REGULATOR receiver
BM523_13065	COG2205	protein histidine kinase activity
BM523_13110	COG2080	2 iron, 2 sulfur cluster binding
BM523_13115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BM523_13120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM523_13140	COG1028	Short-chain dehydrogenase reductase Sdr
BM523_13145	COG4221	oxidoreductase activity
BM523_13150	COG0693	protein deglycase activity
BM523_13155	COG1295	ribonuclease BN
BM523_13170	COG4681	YaeQ
BM523_13200	COG2814	Major facilitator Superfamily
BM523_13220	COG0514	ATP-dependent DNA helicase (RecQ)
BM523_13245	COG3706	GGDEF domain
BM523_13260	COG4251	negative regulation of phosphorylation
BM523_13265	COG2133	pyrroloquinoline quinone binding
BM523_13290	COG3177	Filamentation induced by cAMP protein fic
BM523_13325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM523_13330	COG2971	BadF BadG BcrA BcrD
BM523_13335	COG0583	DNA-binding transcription factor activity
BM523_13340	COG1620	l-lactate permease
BM523_13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM523_13370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM523_13375	COG0006	proline dipeptidase activity
BM523_13390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM523_13405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM523_13410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM523_13415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM523_13435	COG3313	Fe-S protein
BM523_13470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM523_13475	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM523_13480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM523_13485	COG2186	Transcriptional regulator
BM523_13495	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM523_13500	COG3577	Aspartyl protease
BM523_13505	COG0157	Belongs to the NadC ModD family
BM523_13510	COG4969	Belongs to the N-Me-Phe pilin family
BM523_13515	COG1459	type II secretion system
BM523_13520	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM523_13525	COG0237	dephospho-CoA kinase activity
BM523_13525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM523_13530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM523_13540	COG3608	succinylglutamate desuccinylase aspartoacylase
BM523_13555	COG0739	heme binding
BM523_13560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM523_13565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM523_13570	COG0849	cell division
BM523_13575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM523_13580	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM523_13585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM523_13595	COG0772	Belongs to the SEDS family
BM523_13600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM523_13610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM523_13615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM523_13620	COG0768	penicillin binding
BM523_13625	COG3116	cell division
BM523_13635	COG2001	Belongs to the MraZ family
BM523_13660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_13680	COG0678	peroxiredoxin activity
BM523_13680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM523_13695	COG3706	GGDEF domain
BM523_13705	COG2204	response regulator
BM523_13710	COG0784	Response regulator, receiver
BM523_13710	COG2205	protein histidine kinase activity
BM523_13725	COG2271	Major facilitator Superfamily
BM523_13750	COG0668	transmembrane transport
BM523_13755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM523_13760	COG0189	ligase activity
BM523_13765	COG1678	Uncharacterized ACR, COG1678
BM523_13770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM523_13795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM523_13800	COG0762	integral membrane protein
BM523_13810	COG1902	pentaerythritol trinitrate reductase activity
BM523_13810	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM523_13825	COG0625	glutathione transferase activity
BM523_13835	COG1764	response to oxidative stress
BM523_13840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM523_13855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BM523_13865	COG2814	Major facilitator Superfamily
BM523_13870	COG0724	RNA recognition motif
BM523_13895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BM523_13900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM523_13920	COG0583	DNA-binding transcription factor activity
BM523_13935	COG0640	Transcriptional regulator
BM523_13945	COG0431	NADPH-dependent FMN reductase
BM523_13950	COG0798	PFAM Bile acid sodium symporter
BM523_13955	COG2201	protein-glutamate methylesterase activity
BM523_13960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM523_13970	COG3850	Histidine kinase
BM523_13970	COG5002	protein histidine kinase activity
BM523_13985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BM523_14015	COG1748	Saccharopine dehydrogenase
BM523_14030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM523_14035	COG3107	peptidoglycan biosynthetic process
BM523_14055	COG2823	Periplasmic or secreted lipoprotein
BM523_14075	COG4585	Histidine kinase
BM523_14080	COG2197	response regulator
BM523_14105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM523_14110	COG0372	Belongs to the citrate synthase family
BM523_14115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM523_14120	COG2828	Protein conserved in bacteria
BM523_14125	COG2199	diguanylate cyclase activity
BM523_14125	COG2203	Gaf domain
BM523_14145	COG0784	Response regulator, receiver
BM523_14145	COG5002	protein histidine kinase activity
BM523_14145	COG2198	Histidine kinase
BM523_14150	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM523_14155	COG0070	glutamate synthase
BM523_14155	COG0069	glutamate synthase activity
BM523_14155	COG0067	glutamate synthase
BM523_14160	COG0493	'glutamate synthase
BM523_14180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM523_14185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM523_14190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM523_14195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM523_14210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM523_14215	COG5507	3-demethylubiquinone-9 3-methyltransferase
BM523_14220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM523_14225	COG4942	peptidase
BM523_14230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM523_14235	COG0738	Major facilitator superfamily
BM523_14265	COG0625	glutathione transferase activity
BM523_14290	COG2894	cell division
BM523_14295	COG0850	regulation of cytokinetic process
BM523_14305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BM523_14340	COG1914	H( )-stimulated, divalent metal cation uptake system
BM523_14345	COG0436	Aminotransferase
BM523_14360	COG0174	glutamine synthetase
BM523_14370	COG3852	Histidine kinase
BM523_14375	COG2204	response regulator
BM523_14380	COG3437	response regulator, receiver
BM523_14385	COG0204	Acyl-transferase
BM523_14400	COG3706	GGDEF domain
BM523_14420	COG3437	response regulator, receiver
BM523_14420	COG3850	Histidine kinase
BM523_14420	COG4999	Histidine kinase
BM523_14420	COG2205	protein histidine kinase activity
BM523_14425	COG0525	valine-tRNA ligase activity
BM523_14430	COG2927	DNA polymerase III (CHI subunit)
BM523_14435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM523_14440	COG0795	lipopolysaccharide-transporting ATPase activity
BM523_14445	COG0795	lipopolysaccharide-transporting ATPase activity
BM523_14520	COG3459	Glycosyltransferase 36 associated
BM523_14530	COG2199	diguanylate cyclase activity
BM523_14530	COG2203	Gaf domain
BM523_14560	COG0673	inositol 2-dehydrogenase activity
BM523_14565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM523_14565	COG2198	Histidine kinase
BM523_14565	COG2205	protein histidine kinase activity
BM523_14565	COG0784	Response regulator, receiver
BM523_14570	COG0628	permease
BM523_14585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM523_14590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM523_14595	COG4558	Periplasmic binding protein
BM523_14605	COG4206	TonB-dependent receptor
BM523_14615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM523_14620	COG0697	spore germination
BM523_14650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM523_14660	COG0006	proline dipeptidase activity
BM523_14665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM523_14670	COG0745	RESPONSE REGULATOR receiver
BM523_14670	COG3706	GGDEF domain
BM523_14675	COG0679	Auxin Efflux Carrier
BM523_14685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM523_14695	COG0395	ABC-type sugar transport system, permease component
BM523_14715	COG2267	carboxylic ester hydrolase activity
BM523_14745	COG1131	(ABC) transporter
BM523_14755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM523_14805	COG2205	protein histidine kinase activity
BM523_14815	COG3901	Regulator of nitric oxide reductase transcription
BM523_14815	COG0348	domain, Protein
BM523_14825	COG2197	response regulator
BM523_14860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM523_14865	COG0277	FAD linked oxidase domain protein
BM523_14875	COG1462	curli production assembly transport component CsgG
BM523_14905	COG2197	response regulator
BM523_14930	COG0513	Belongs to the DEAD box helicase family
BM523_14935	COG5001	Diguanylate cyclase
BM523_14945	COG0800	Aldolase
BM523_14950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM523_14965	COG3264	Mechanosensitive ion channel
BM523_14965	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM523_15005	COG0730	response to heat
BM523_15025	COG4191	Histidine kinase
BM523_15035	COG0417	DNA replication proofreading
BM523_15045	COG0318	PFAM AMP-dependent synthetase and ligase
BM523_15090	COG1309	transcriptional regulator
BM523_15100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM523_15110	COG1573	uracil-dna glycosylase
BM523_15115	COG3300	MHYT domain
BM523_15115	COG5001	Diguanylate cyclase
BM523_15135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM523_15155	COG1983	PspC domain protein
BM523_15160	COG1842	Phage shock protein A
BM523_15170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM523_15195	COG1621	beta-fructofuranosidase activity
BM523_15220	COG0438	transferase activity, transferring glycosyl groups
BM523_15250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM523_15260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM523_15265	COG0204	Acyl-transferase
BM523_15270	COG0204	Acyl-transferase
BM523_15275	COG0668	transmembrane transport
BM523_15290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM523_15295	COG0733	neurotransmitter:sodium symporter activity
BM523_15310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM523_15325	COG0716	FMN binding
BM523_15335	COG0848	biopolymer transport protein
BM523_15345	COG0457	Tetratricopeptide repeat
BM523_15350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM523_15360	COG1215	transferase activity, transferring glycosyl groups
BM523_15375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM523_15380	COG0702	epimerase
BM523_15395	COG5001	Diguanylate cyclase
BM523_15395	COG5002	protein histidine kinase activity
BM523_15405	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM523_15415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM523_15425	COG0583	DNA-binding transcription factor activity
BM523_15430	COG0121	glutamine amidotransferase
BM523_15440	COG4682	membrane
BM523_15460	COG1953	Uracil, thiamine, allantoin
BM523_15465	COG4771	TonB-dependent receptor
BM523_15475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM523_15485	COG0596	Alpha beta hydrolase
BM523_15490	COG0251	oxidation-reduction process
BM523_15495	COG1335	isochorismatase
BM523_15500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM523_15505	COG1309	transcriptional regulator
BM523_15520	COG4628	conserved protein (DUF2132)
BM523_15540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BM523_15545	COG1609	Transcriptional regulator
BM523_15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM523_15560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM523_15580	COG1477	protein flavinylation
BM523_15585	COG2871	sodium ion transport
BM523_15590	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM523_15595	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM523_15600	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM523_15605	COG1805	sodium ion transport
BM523_15610	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM523_15615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM523_15620	COG0545	Peptidyl-prolyl cis-trans isomerase
BM523_15625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM523_15640	COG0039	L-malate dehydrogenase activity
BM523_15645	COG1438	arginine binding
BM523_15670	COG0572	uridine kinase
BM523_15675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM523_15695	COG3706	GGDEF domain
BM523_15695	COG0745	RESPONSE REGULATOR receiver
BM523_15700	COG2176	DNA-directed DNA polymerase activity
BM523_15710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM523_15720	COG2205	protein histidine kinase activity
BM523_15730	COG0189	ligase activity
BM523_15740	COG4067	protein conserved in archaea
BM523_15740	COG0189	ligase activity
BM523_15765	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM523_15770	COG0667	Aldo Keto reductase
BM523_15795	COG2815	serine threonine protein kinase
BM523_15795	COG0515	serine threonine protein kinase
BM523_15880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM523_15890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM523_15940	COG2274	protein secretion by the type I secretion system
BM523_15945	COG0583	DNA-binding transcription factor activity
BM523_15980	COG0438	transferase activity, transferring glycosyl groups
BM523_15980	COG1216	Glycosyl transferase, family 2
BM523_15990	COG1091	dTDP-4-dehydrorhamnose reductase activity
BM523_16010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM523_16050	COG0463	Glycosyl transferase, family 2
BM523_16055	COG2089	acid synthase
BM523_16070	COG1083	cytidylyl-transferase
BM523_16075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM523_16080	COG1086	Polysaccharide biosynthesis protein
BM523_16105	COG0202	RNA polymerase activity
BM523_16130	COG0201	protein transport
BM523_16150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BM523_16185	COG0784	Response regulator, receiver
BM523_16185	COG5002	protein histidine kinase activity
BM523_16205	COG0557	exoribonuclease II activity
BM523_16225	COG4771	TonB-dependent receptor
BM523_16240	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM523_16265	COG2234	aminopeptidase activity
BM523_16275	COG4251	negative regulation of phosphorylation
BM523_16295	COG1271	oxidase subunit
BM523_16300	COG1294	oxidase, subunit
BM523_16305	COG1522	sequence-specific DNA binding
BM523_16315	COG1278	Cold shock
BM523_16320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM523_16340	COG0339	signal peptide processing
BM523_16345	COG2201	protein-glutamate methylesterase activity
BM523_16355	COG3852	Histidine kinase
BM523_16365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM523_16370	COG0243	molybdopterin cofactor binding
BM523_16375	COG0823	Involved in the tonB-independent uptake of proteins
BM523_16375	COG4946	Tricorn protease homolog
BM523_16375	COG1506	peptidase
BM523_16420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM523_16430	COG2197	response regulator
BM523_16460	COG1621	beta-fructofuranosidase activity
BM523_16465	COG2814	Major facilitator Superfamily
BM523_16475	COG1629	transport
BM523_16475	COG4206	TonB-dependent receptor
BM523_16485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM523_16490	COG1278	Cold shock
BM523_16495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM523_16500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM523_16515	COG0281	malic enzyme
BM523_16525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM523_16555	COG0456	acetyltransferase
BM523_16565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM523_16570	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM523_16575	COG2177	Part of the ABC transporter FtsEX involved in
BM523_16580	COG2884	Cell division ATP-binding protein ftsE
BM523_16585	COG0552	protein localization to endoplasmic reticulum
BM523_16590	COG0742	ribosomal rna small subunit methyltransferase
BM523_16600	COG2095	MarC family integral membrane protein
BM523_16620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM523_16625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM523_16630	COG0617	tRNA 3'-terminal CCA addition
BM523_16635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM523_16650	COG0076	glutamate decarboxylase activity
BM523_16665	COG0842	Transport permease protein
BM523_16670	COG1131	(ABC) transporter
BM523_16675	COG0745	RESPONSE REGULATOR receiver
BM523_16680	COG2205	protein histidine kinase activity
BM523_16685	COG4774	siderophore transport
BM523_16710	COG1253	flavin adenine dinucleotide binding
BM523_16720	COG1966	Carbon starvation protein
BM523_16750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM523_16755	COG0049	tRNA binding
BM523_16760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM523_16765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM523_16770	COG0085	RNA polymerase activity
BM523_16775	COG0222	ribosome binding
BM523_16780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM523_16785	COG0081	regulation of translation
BM523_16790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM523_16810	COG0250	Participates in transcription elongation, termination and antitermination
BM523_16815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM523_16825	COG1132	(ABC) transporter
BM523_16830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM523_16835	COG3590	peptidase
BM523_16845	COG0513	Belongs to the DEAD box helicase family
BM523_16850	COG0418	dihydroorotase activity
BM523_16855	COG3040	lipid binding
BM523_16860	COG4989	oxidoreductase activity
BM523_16865	COG0346	lactoylglutathione lyase activity
BM523_16870	COG0668	transmembrane transport
BM523_16890	COG0302	gtp cyclohydrolase
BM523_16900	COG2957	Belongs to the agmatine deiminase family
BM523_16905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM523_16915	COG1201	RNA secondary structure unwinding
BM523_16925	COG1793	dna ligase
BM523_16930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM523_16935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM523_16950	COG0625	glutathione transferase activity
BM523_16955	COG0625	glutathione transferase activity
BM523_16965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM523_16980	COG1012	belongs to the aldehyde dehydrogenase family
BM523_16985	COG0028	Belongs to the TPP enzyme family
BM523_16995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM523_17000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM523_17005	COG0330	HflC and HflK could
BM523_17010	COG0330	HflC and HflK could
BM523_17015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM523_17020	COG1923	regulation of RNA biosynthetic process
BM523_17025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM523_17040	COG0802	atpase or kinase
BM523_17045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM523_17045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM523_17050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM523_17060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM523_17070	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BM523_17075	COG0735	belongs to the Fur family
BM523_17085	COG0432	Pfam Uncharacterised protein family UPF0047
BM523_17095	COG0305	Participates in initiation and elongation during chromosome replication
BM523_17120	COG2258	MOSC domain
BM523_17180	COG2205	protein histidine kinase activity
BM523_17180	COG2198	Histidine kinase
BM523_17180	COG0784	Response regulator, receiver
BM523_17190	COG0577	efflux transmembrane transporter activity
BM523_17190	COG1136	(ABC) transporter
BM523_17200	COG0840	transmembrane signaling receptor activity
BM523_17205	COG5002	protein histidine kinase activity
BM523_17210	COG0840	transmembrane signaling receptor activity
BM523_17225	COG2855	membrane
BM523_17230	COG2175	clavaminate synthase activity
BM523_17235	COG0656	L-ascorbic acid biosynthetic process
BM523_17250	COG1501	Belongs to the glycosyl hydrolase 31 family
BM523_17255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM523_17260	COG4771	TonB-dependent receptor
BM523_17285	COG1472	Belongs to the glycosyl hydrolase 3 family
BM523_17295	COG2723	6-phospho-beta-galactosidase activity
BM523_17300	COG1609	Transcriptional regulator
BM523_17305	COG0477	Major facilitator Superfamily
BM523_17305	COG2814	Major facilitator Superfamily
BM523_17310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM523_17315	COG4988	ABC transporter
BM523_17320	COG4890	Cyd operon protein YbgT
BM523_17325	COG1294	oxidase, subunit
BM523_17365	COG4319	ketosteroid isomerase
BM523_17375	COG4771	TonB-dependent receptor
BM523_17390	COG1469	GTP cyclohydrolase I activity
BM523_17405	COG2375	cellular response to nickel ion
BM523_17410	COG3237	CsbD-like
BM523_17425	COG1595	DNA-templated transcription, initiation
BM523_17430	COG1404	Belongs to the peptidase S8 family
BM523_17455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM523_17455	COG0596	Alpha beta hydrolase
BM523_17475	COG3038	cytochrome b561
BM523_17485	COG1252	NADH dehydrogenase
BM523_17500	COG0583	DNA-binding transcription factor activity
BM523_17505	COG2067	long-chain fatty acid transport protein
BM523_17510	COG2130	NADP-dependent
BM523_17515	COG4251	negative regulation of phosphorylation
BM523_17515	COG2203	Gaf domain
BM523_17515	COG5001	Diguanylate cyclase
BM523_17515	COG3706	GGDEF domain
BM523_17520	COG2205	protein histidine kinase activity
BM523_17520	COG0784	Response regulator, receiver
BM523_17530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM523_17535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM523_17540	COG1349	DNA-binding transcription factor activity
BM523_17545	COG0673	inositol 2-dehydrogenase activity
BM523_17560	COG0697	spore germination
BM523_17565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM523_17570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM523_17575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM523_17580	COG1166	arginine decarboxylase activity
BM523_17590	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM523_17595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM523_17600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM523_17650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM523_17670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BM523_17680	COG0328	RNA-DNA hybrid ribonuclease activity
BM523_17705	COG3030	protein affecting phage T7 exclusion by the F plasmid
BM523_17710	COG1324	tolerance protein
BM523_17715	COG4232	protein-disulfide reductase activity
BM523_17720	COG0739	heme binding
BM523_17725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM523_17730	COG0511	ligase activity, forming carbon-carbon bonds
BM523_17735	COG0439	Biotin carboxylase
BM523_17775	COG0154	amidase activity
BM523_17790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM523_17795	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM523_17810	COG0151	Belongs to the GarS family
BM523_17830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM523_17835	COG3954	Phosphoribulokinase
BM523_17845	COG0745	RESPONSE REGULATOR receiver
BM523_17860	COG1501	Belongs to the glycosyl hydrolase 31 family
BM523_17940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM523_17950	COG3031	protein transport across the cell outer membrane
BM523_17960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM523_17965	COG1459	type II secretion system
BM523_17970	COG2165	general secretion pathway protein
BM523_17975	COG2165	general secretion pathway protein
BM523_17985	COG4795	General secretion pathway protein
BM523_18000	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM523_18015	COG1012	belongs to the aldehyde dehydrogenase family
BM523_18025	COG1011	Hydrolase
BM523_18030	COG0494	nUDIX hydrolase
BM523_18035	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM523_18050	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM523_18060	COG3089	Belongs to the UPF0270 family
BM523_18065	COG0429	hydrolase of the alpha beta-hydrolase fold
BM523_18075	COG0488	(ABC) transporter
BM523_18100	COG0545	Peptidyl-prolyl cis-trans isomerase
BM523_18110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM523_18115	COG2183	response to ionizing radiation
BM523_18135	COG0596	Alpha beta hydrolase
BM523_18140	COG1040	competence protein
BM523_18160	COG1794	racemase activity, acting on amino acids and derivatives
BM523_18175	COG0534	Mate efflux family protein
BM523_18180	COG1649	PFAM Uncharacterised BCR, COG1649
BM523_18180	COG0726	polysaccharide deacetylase
BM523_18190	COG1999	signal sequence binding
BM523_18195	COG0109	protoheme IX farnesyltransferase activity
BM523_18200	COG1612	heme a metabolic process
BM523_18220	COG1845	cytochrome c oxidase, subunit III
BM523_18225	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BM523_18230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM523_18235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM523_18255	COG0129	dihydroxy-acid dehydratase activity
BM523_18265	COG0606	chelatase, subunit chli
BM523_18270	COG0583	DNA-binding transcription factor activity
BM523_18280	COG2814	Major facilitator Superfamily
BM523_18285	COG1073	alpha beta
BM523_18290	COG0729	surface antigen
BM523_18295	COG2911	Protein conserved in bacteria
BM523_18320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM523_18330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM523_18350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM523_18375	COG1228	amidohydrolase
BM523_18400	COG0425	Belongs to the sulfur carrier protein TusA family
BM523_18415	COG1561	YicC-like family, N-terminal region
BM523_18435	COG2723	6-phospho-beta-galactosidase activity
BM523_18440	COG2211	Major facilitator Superfamily
BM523_18445	COG1609	Transcriptional regulator
BM523_18460	COG2199	diguanylate cyclase activity
BM523_18460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BM523_18485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM523_18505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM523_18510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM523_18530	COG1475	DNA binding
BM523_18535	COG1192	Involved in chromosome partitioning
BM523_18560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM523_18565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM523_18575	COG0706	membrane insertase activity
BM523_18580	COG0594	ribonuclease P activity