locus-tag class description BM524_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BM524_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BM524_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BM524_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_00040 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BM524_00045 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit BM524_00050 ENOG4108R3E Dna-3-methyladenine glycosylase i BM524_00060 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BM524_00070 ENOG4106RE7 Cytochrome BM524_00075 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BM524_00080 ENOG4105C2M dna polymerase I BM524_00085 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BM524_00090 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BM524_00095 ENOG4105C1A potassium transporter peripheral membrane BM524_00100 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BM524_00105 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BM524_00110 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BM524_00120 ENOG4105C79 DNA protecting protein DprA BM524_00125 ENOG4108RPN Protein smg homolog BM524_00135 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BM524_00140 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BM524_00145 ENOG4105EIF outer membrane protein W BM524_00155 ENOG4105E2X shikimate dehydrogenase BM524_00160 ENOG4108Z0R Transferase BM524_00200 ENOG4105C0B DNA polymerase III (alpha subunit) BM524_00230 ENOG4105IIU Aminopeptidase BM524_00240 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BM524_00245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BM524_00250 ENOG4105W5Q DNA repair protein (RadC BM524_00270 ENOG4105E3R (LipO)protein BM524_00275 ENOG4105KDC 50s ribosomal protein l28 BM524_00280 ENOG4105W0E 50S ribosomal protein L33 BM524_00290 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BM524_00295 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BM524_00300 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) BM524_00305 ENOG4105DKP glycosyl transferase, family 9 BM524_00320 ENOG4105BZU Histidine kinase BM524_00325 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BM524_00330 ENOG4105CPQ Dehydrogenase BM524_00335 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BM524_00350 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BM524_00355 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BM524_00370 ENOG4105W0Z cytoplasmic protein BM524_00375 ENOG4105C4R Atp-dependent dna helicase BM524_00380 ENOG4105BZU Histidine kinase BM524_00385 ENOG4105MPD Cytochrome BM524_00395 ENOG4107ZSV Receptor BM524_00405 ENOG4105D2S major facilitator superfamily BM524_00420 ENOG4107SET aldo keto reductase BM524_00440 ENOG4105GAK amidohydrolase 2 BM524_00445 ENOG4105KHM amidohydrolase 2 BM524_00455 ENOG4105JSC dimethylmenaquinone methyltransferase BM524_00475 ENOG4105DFD Na H antiporter BM524_00495 ENOG4108VCT Sulfite exporter TauE/SafE BM524_00510 ENOG4105UGU tonB-dependent Receptor BM524_00525 ENOG4108JJ8 (ABC) transporter BM524_00530 ENOG4108JJ9 ABC, transporter BM524_00540 ENOG4105C4M (Ubiquinol oxidase) subunit I BM524_00545 ENOG4105VFE sira family BM524_00555 ENOG4105D3R alkyl hydroperoxide reductase BM524_00560 ENOG4105C94 Transporter BM524_00590 ENOG4105D0S secretion protein (HlyD BM524_00595 ENOG4105CJ1 ABC, transporter BM524_00600 ENOG4105CMI transporter BM524_00610 ENOG4107RNH Outer membrane receptor FepA BM524_00625 ENOG4105DQS Transcriptional regulator BM524_00635 ENOG4105CM6 amino acid regulated cytosolic protein BM524_00650 ENOG4105D41 biosynthesis protein thiH BM524_00655 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BM524_00665 ENOG4105D06 uba thif-type nad fad binding protein BM524_00670 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BM524_00675 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BM524_00680 ENOG410601J HemY protein BM524_00685 ENOG4105ECF c-methyltransferase BM524_00690 ENOG41076E6 Uroporphyrinogen-III Synthase BM524_00695 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BM524_00700 ENOG4105BZU Histidine kinase BM524_00710 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BM524_00715 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BM524_00720 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BM524_00725 ENOG4105KME endoribonuclease L-psp BM524_00730 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase BM524_00735 ENOG4105CB5 ATP-dependent DNA helicase recG BM524_00740 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BM524_00760 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component BM524_00765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BM524_00775 ENOG4105CBX hi0933 family BM524_00785 ENOG4105BZU Histidine kinase BM524_00790 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BM524_00800 ENOG4105KPY Small multidrug resistance protein BM524_00815 ENOG4105C1P efflux transporter, rnd family, mfp subunit BM524_00820 ENOG4105BZS acriflavin resistance protein BM524_00830 ENOG4105CYC Transferase BM524_00850 ENOG4105C8Q Methyl-accepting chemotaxis BM524_00860 ENOG4108NST exported protein BM524_00865 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BM524_00870 ENOG4105BZU Histidine kinase BM524_00885 ENOG4105C9U ATP-dependent DNA helicase RecQ BM524_00890 ENOG4105CJW magnesium transporter BM524_00895 ENOG4105FR1 rard protein BM524_00900 ENOG4105BZU Histidine kinase BM524_00905 ENOG4105C4R Atp-dependent dna helicase BM524_00910 ENOG4105D7W serine acetyltransferase BM524_00915 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BM524_00920 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BM524_00930 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BM524_00935 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BM524_00955 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BM524_00965 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BM524_00970 ENOG4105DFU Cell wall formation (By similarity) BM524_00975 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BM524_00980 ENOG4105F0N pyrophosphate phospho-hydrolase BM524_01020 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BM524_01025 ENOG4107RDB Major Facilitator BM524_01030 ENOG4107VXZ Hydrolase BM524_01055 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BM524_01060 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BM524_01075 ENOG4107XMK single-stranded DNA-binding protein BM524_01100 ENOG4107RUZ Sss sodium solute transporter superfamily BM524_01120 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BM524_01125 ENOG4105E98 transcriptional regulator DeoR family BM524_01130 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BM524_01180 ENOG4107QHF type ii secretion system protein e BM524_01185 ENOG4105D7Q type ii secretion system BM524_01230 ENOG4105DFF Rod shape-determining protein mreb BM524_01235 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BM524_01240 ENOG4105VQ7 Rod shape-determining protein MreD BM524_01245 ENOG4108Z03 MAF-like protein BM524_01250 ENOG4105C03 ribonuclease BM524_01265 ENOG4105D1U peptidase U62 modulator of DNA gyrase BM524_01270 ENOG4105N42 UPF0307 protein BM524_01275 ENOG4105CMS peptidase U62, modulator of DNA gyrase BM524_01285 ENOG4105CNT hydrolase family 2 BM524_01290 ENOG41065U4 response regulator BM524_01295 ENOG4105BZU Histidine kinase BM524_01300 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BM524_01305 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BM524_01310 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BM524_01315 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BM524_01320 ENOG4105CEN a g-specific adenine glycosylase BM524_01325 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BM524_01355 ENOG4108C33 Resolvase BM524_01370 ENOG4105NI8 Cytosine-specific methyltransferase BM524_01385 ENOG4105C8Q Methyl-accepting chemotaxis BM524_01390 ENOG4108VYJ response regulator receiver protein BM524_01395 ENOG4105CBS Chea signal transduction histidine kinase BM524_01400 ENOG4108V3W Chemotaxis protein, CheW BM524_01405 ENOG4107SDU Methyl-accepting chemotaxis BM524_01410 ENOG4105BZU Histidine kinase BM524_01415 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BM524_01420 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BM524_01425 ENOG4105C8Q Methyl-accepting chemotaxis BM524_01430 ENOG4108VYJ response regulator receiver protein BM524_01435 ENOG4105CBS Chea signal transduction histidine kinase BM524_01440 ENOG4108V3W Chemotaxis protein, CheW BM524_01445 ENOG4107SDU Methyl-accepting chemotaxis BM524_01450 ENOG4107SDU Methyl-accepting chemotaxis BM524_01455 ENOG4105BZU Histidine kinase BM524_01460 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BM524_01510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BM524_01530 ENOG4105ETE Transcriptional regulator (LacI family BM524_01545 ENOG4105EAA nucleoside BM524_01570 ENOG4105C0A alcohol dehydrogenase BM524_01600 ENOG4105CM2 brancheD-chain amino acid aminotransferase BM524_01605 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BM524_01615 ENOG4107QM5 aconitate hydratase BM524_01625 ENOG4107QHF type ii secretion system protein e BM524_01635 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BM524_01640 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BM524_01645 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BM524_01650 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BM524_01655 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BM524_01660 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BM524_01665 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BM524_01670 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BM524_01675 ENOG41083MP 50s ribosomal protein l29 BM524_01680 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BM524_01685 ENOG4107RJ7 Glycosyl transferase (Group 1 BM524_01695 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BM524_01715 ENOG41069D7 Methyl-accepting chemotaxis BM524_01720 ENOG4105DGW oligopeptidase A BM524_01740 ENOG4105CQ7 ATP-dependent helicase BM524_01745 ENOG4105CVE Lytic murein transglycosylase BM524_01750 ENOG4105BZ4 penicillin-binding protein BM524_01760 ENOG4105CKW Inner membrane protein yedI BM524_01770 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF BM524_01780 ENOG4108YZA Nitrogen regulatory protein pii BM524_01790 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BM524_01795 ENOG4105EZR dyp-type peroxidase family protein BM524_01805 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BM524_01810 ENOG4105CXT aspartate transcarbamylase BM524_01835 ENOG4105BZU Histidine kinase BM524_01840 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_01850 ENOG4105BZU Histidine kinase BM524_01860 ENOG4105C26 Dehydrogenase BM524_01870 ENOG4105C8Y Acetylornithine aminotransferase BM524_01885 ENOG4105C31 Tryptophanyl-tRNA synthetase BM524_01890 ENOG4105DJV ribulose-phosphate 3-epimerase BM524_01910 ENOG4105DFE Dna adenine methylase BM524_01920 ENOG4105D49 3-dehydroquinate synthase BM524_01925 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BM524_01930 ENOG4105E4G Type IV pilus BM524_01955 ENOG4108JQC penicillin-binding protein 1A BM524_01960 ENOG4107R1I NAD-dependent malic enzyme BM524_01970 ENOG4105CYM Glutathione S-transferase BM524_01980 ENOG4105CH6 catalase BM524_02005 ENOG4105BZU Histidine kinase BM524_02010 ENOG4107QZM n-acetylglutamate synthase BM524_02015 ENOG4105CH7 arginosuccinase BM524_02020 ENOG4105CDH Citrulline--aspartate ligase BM524_02030 ENOG4105CAS nag kinase BM524_02035 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BM524_02040 ENOG4108Z5K methylglyoxal synthase BM524_02050 ENOG4105E3W Two component transcriptional regulator (Winged helix family BM524_02055 ENOG4105E0F Histidine kinase BM524_02060 ENOG4108EUD Lysophospholipase BM524_02065 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BM524_02075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BM524_02080 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BM524_02090 ENOG4107YZP Rhodanese domain protein BM524_02095 ENOG41063SB peptidase BM524_02100 ENOG4105PXI polysaccharide deacetylase BM524_02120 ENOG4105DJ4 phosphatidylserine decarboxylase BM524_02125 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BM524_02130 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BM524_02150 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_02155 ENOG4107RDJ Sulfotransferase BM524_02170 ENOG4105C7K acetolactate synthase BM524_02175 ENOG4108ZP8 Acetolactate synthase small subunit BM524_02185 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BM524_02190 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BM524_02195 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BM524_02205 ENOG4105F8V Hydrolase, tatD family BM524_02215 ENOG4105D52 delta-aminolevulinic acid dehydratase BM524_02220 ENOG4105C9X ppx gppa phosphatase BM524_02225 ENOG4105C1J atp-dependent rna helicase BM524_02230 ENOG4105K63 Thioredoxin BM524_02240 ENOG4105CH2 amidohydrolase BM524_02245 ENOG4105BZU Histidine kinase BM524_02250 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BM524_02255 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BM524_02260 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BM524_02285 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BM524_02295 ENOG4107QR8 Thioredoxin BM524_02315 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BM524_02320 ENOG4105C26 Dehydrogenase BM524_02340 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BM524_02345 ENOG4107S6Z Na H antiporter BM524_02360 ENOG4105EHZ conserved protein UCP016719 BM524_02365 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BM524_02370 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BM524_02385 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BM524_02400 ENOG4105K3M )-transporter BM524_02410 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BM524_02415 ENOG4105I4A GCN5-related N-acetyltransferase BM524_02450 ENOG4105CHU acetyl-coa acetyltransferase BM524_02455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BM524_02460 ENOG4107SC1 transglycosylase BM524_02465 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) BM524_02475 ENOG4105EAH synthase BM524_02480 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BM524_02485 ENOG4105K46 50S ribosomal protein l27 BM524_02490 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BM524_02505 ENOG4108K5P (LipO)protein BM524_02510 ENOG4108UM1 dedA family BM524_02515 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BM524_02520 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BM524_02525 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BM524_02530 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BM524_02535 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BM524_02545 ENOG4105C8Q Methyl-accepting chemotaxis BM524_02580 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BM524_02585 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BM524_02590 ENOG4105HF0 Membrane BM524_02595 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BM524_02600 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BM524_02610 ENOG4105BZU Histidine kinase BM524_02630 ENOG4105D3G Pseudouridine synthase BM524_02635 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BM524_02645 ENOG4108IAB Phoh family BM524_02655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BM524_02660 ENOG4105C1J atp-dependent rna helicase BM524_02675 ENOG4105DFG type I secretion outer membrane protein BM524_02680 ENOG41087AY ADP-Ribose pyrophosphatase BM524_02690 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BM524_02695 ENOG4105IPS esterase BM524_02700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_02710 ENOG4107VXZ Hydrolase BM524_02735 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BM524_02740 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BM524_02745 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BM524_02750 ENOG4105UGU tonB-dependent Receptor BM524_02760 ENOG41068WN BM524_02765 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BM524_02770 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BM524_02780 ENOG4105M85 Bola protein BM524_02810 ENOG4105CHH sulfate transporter BM524_02815 ENOG4107QZF nitrite reductase NADPH large subunit BM524_02830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BM524_02835 ENOG4108I0Q anthranilate phosphoribosyltransferase BM524_02840 ENOG4107SDU Methyl-accepting chemotaxis BM524_02855 ENOG4105D7T ABC transporter BM524_02870 ENOG4108Z33 Thiol disulfide Interchange Protein BM524_02875 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_02880 ENOG4105E27 serine threonine protein kinase BM524_02885 ENOG4105C58 cytochrome c oxidase accessory protein ccog BM524_02900 ENOG4105CSU acyl-Coa dehydrogenase BM524_02905 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BM524_02915 ENOG4105CXK mandelate racemase muconate lactonizing BM524_02920 ENOG4105MP9 class II Aldolase BM524_02930 ENOG410624X efflux transporter, rnd family, mfp subunit BM524_02935 ENOG4105BZS acriflavin resistance protein BM524_02950 ENOG4105C8Q Methyl-accepting chemotaxis BM524_02955 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_02960 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BM524_02965 ENOG4105KTH gatB Yqey BM524_02970 ENOG4105VCC 30S ribosomal protein S21 BM524_02975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BM524_02985 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BM524_02990 ENOG4107ZVW dihydroneopterin aldolase BM524_03000 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BM524_03005 ENOG4105K59 histidine triad (HIT) protein BM524_03020 ENOG4105DKK Benzoate BM524_03025 ENOG4108JCI Transcriptional regulator BM524_03030 ENOG4105DH7 May be involved in recombination (By similarity) BM524_03035 ENOG4105BZU Histidine kinase BM524_03040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BM524_03045 ENOG4105BZU Histidine kinase BM524_03080 ENOG4109015 Biopolymer transport protein exbD tolR BM524_03085 ENOG41067XB TonB family BM524_03095 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_03100 ENOG4105BZU Histidine kinase BM524_03105 ENOG4105CEY Amp-dependent synthetase and ligase BM524_03120 ENOG4107QIJ Aconitate hydratase 2 BM524_03125 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BM524_03145 ENOG4107QIJ Aconitate hydratase 2 BM524_03155 ENOG4105CFH Aspartokinase BM524_03160 ENOG4108NVR Methyl-accepting chemotaxis BM524_03165 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BM524_03170 ENOG4105NWN ApaG protein BM524_03175 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BM524_03180 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BM524_03185 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BM524_03190 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BM524_03195 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BM524_03200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BM524_03205 ENOG4105T95 Thiol disulfide interChange protein BM524_03210 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BM524_03220 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BM524_03225 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BM524_03230 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BM524_03235 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BM524_03240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BM524_03245 ENOG4105DXN mazG family BM524_03265 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BM524_03270 ENOG4108UJD 30S ribosomal protein S9 BM524_03275 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BM524_03280 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BM524_03285 ENOG4105EIX cytochrome c1 BM524_03290 ENOG4107MKT Stringent starvation protein a BM524_03295 ENOG4105KB2 stringent starvation protein b BM524_03310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BM524_03315 ENOG4105CJW magnesium transporter BM524_03320 ENOG41080Z8 PHOSPHOCARRIER protein BM524_03325 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BM524_03330 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BM524_03335 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BM524_03340 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_03345 ENOG4108IUZ ABC transporter BM524_03350 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BM524_03360 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BM524_03365 ENOG4105C2X Arabinose 5-phosphate isomerase BM524_03375 ENOG4105DHJ ABC, transporter BM524_03380 ENOG4105CY3 ABC transporter, permease BM524_03385 ENOG4107PE3 Mammalian cell entry related domain protein BM524_03390 ENOG4105E3I toluene tolerance BM524_03400 ENOG4105VFK BolA family BM524_03405 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BM524_03410 ENOG4105C0H protease BM524_03415 ENOG4105C0H protease BM524_03425 ENOG4105D6Z AFG1 family ATPase BM524_03430 ENOG4105CDY transcriptional regulatory protein BM524_03445 ENOG4105BZU Histidine kinase BM524_03450 ENOG4108RCM Nitroreductase BM524_03460 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BM524_03475 ENOG4105D05 Receptor BM524_03480 ENOG4108RNG Permease of the drug metabolite transporter BM524_03485 ENOG4105BZU Histidine kinase BM524_03505 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BM524_03510 ENOG4105CV1 Transketolase (EC 2.2.1.1) BM524_03515 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BM524_03520 ENOG4105BZA Phosphoglycerate kinase BM524_03525 ENOG4105WYW fructose-bisphosphate aldolase BM524_03535 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BM524_03540 ENOG4105C9X ppx gppa phosphatase BM524_03555 ENOG4105C8U phosphate abc transporter BM524_03565 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BM524_03575 ENOG4105CJ3 phosphate transporter BM524_03585 ENOG4105C5Q Transcriptional regulator BM524_03595 ENOG4108UT2 hemolysin iii BM524_03600 ENOG4105K56 Transcriptional regulator BM524_03605 ENOG4108ZHJ Organic hydroperoxide resistance protein BM524_03620 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BM524_03630 ENOG4105HEI LysR family (Transcriptional regulator BM524_03635 ENOG4107QM2 Aldo Keto reductase BM524_03650 ENOG4107RH8 nuclease SbcCD subunit D BM524_03655 ENOG4105EYH Exonuclease BM524_03665 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BM524_03685 ENOG4105CI2 imidazolone-5-propionate hydrolase BM524_03690 ENOG4105CZE histidine utilization repressor BM524_03695 ENOG4105CGP Urocanate hydratase BM524_03700 ENOG4105C84 Histidine ammonia-lyase BM524_03725 ENOG4105C5H ABC transporter BM524_03750 ENOG4105D64 Mechanosensitive ion channel BM524_03765 ENOG4108KU3 Integrase BM524_03770 ENOG4108HMN Caspase domain BM524_03810 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) BM524_03815 ENOG4107IIZ CRISPR-associated helicase, Cas3 BM524_03865 ENOG41067MG lrgb family BM524_03895 ENOG4105CSA Coproporphyrinogen iii oxidase BM524_03905 ENOG4105C1J atp-dependent rna helicase BM524_03910 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BM524_03925 ENOG4105CPI Metal Dependent Phosphohydrolase BM524_03930 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BM524_03935 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BM524_03940 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BM524_03945 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BM524_03960 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BM524_03965 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BM524_03970 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BM524_03980 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BM524_03985 ENOG4108IUW ABC transporter BM524_03990 ENOG4108SDH ABC, transporter BM524_04000 ENOG4107EXC regulatoR BM524_04030 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BM524_04035 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BM524_04040 ENOG41060IM Heme exporter protein BM524_04045 ENOG4105X3C heme exporter protein BM524_04050 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BM524_04055 ENOG4105DA4 cytochrome c-type biogenesis protein BM524_04060 ENOG4107QX9 Thiol disulfide interChange protein BM524_04065 ENOG4108M1T Cytochrome c-type biogenesis protein BM524_04075 ENOG410903C (LipO)protein BM524_04080 ENOG4105CMR udp-glucose 4-epimerase BM524_04090 ENOG4105DUX Transporter BM524_04100 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BM524_04105 ENOG4105KQC Competence protein BM524_04110 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BM524_04125 ENOG4105EWT decarboxylase family BM524_04130 ENOG4105BZU Histidine kinase BM524_04135 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BM524_04140 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BM524_04175 ENOG4105DR9 pseudouridine synthase BM524_04180 ENOG4105QDK Flavodoxin BM524_04185 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BM524_04190 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BM524_04195 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BM524_04200 ENOG4105CE9 30S ribosomal protein S2 BM524_04205 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BM524_04210 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BM524_04215 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BM524_04220 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BM524_04225 ENOG4105KNE Phosphatidate cytidylyltransferase BM524_04230 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BM524_04240 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BM524_04245 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BM524_04250 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BM524_04255 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BM524_04260 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BM524_04265 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BM524_04270 ENOG4105C0B DNA polymerase III (alpha subunit) BM524_04275 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BM524_04280 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BM524_04285 ENOG4105BZU Histidine kinase BM524_04300 ENOG4108Z6B deaminase BM524_04305 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BM524_04310 ENOG4108ETH Formylglycinamide ribotide synthetase BM524_04315 ENOG4108DG9 Smr protein MutS2 BM524_04340 ENOG4108JJA ABC, transporter BM524_04350 ENOG4105WH1 Two component transcriptional regulator luxr family BM524_04390 ENOG4107R88 Chemotaxis protein (CheV) BM524_04395 ENOG4105BZU Histidine kinase BM524_04400 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BM524_04405 ENOG4108ZC9 flagellar basal-body rod protein flgc BM524_04410 ENOG4105W00 Flagellar hook capping protein BM524_04415 ENOG4105BZE flagellar hook protein, FlgE BM524_04420 ENOG4108KPB Flagellar basal-body rod protein FlgF BM524_04425 ENOG4105CGA flagellar basal-body rod protein FlgG BM524_04430 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BM524_04435 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BM524_04440 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BM524_04445 ENOG4105E1Q flagellar hook-associated protein BM524_04460 ENOG4105I03 Flagellin BM524_04465 ENOG4105I03 Flagellin BM524_04470 ENOG4105I03 Flagellin BM524_04475 ENOG41063QE flagellar protein FlaG BM524_04485 ENOG4105MQ3 flagellar protein FliS BM524_04530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BM524_04535 ENOG4108F26 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BM524_04540 ENOG4108TJN glycosyl transferase group 1 BM524_04545 ENOG4105C30 Nad-dependent epimerase dehydratase BM524_04555 ENOG4105X1N Glycosyl transferase family 8 BM524_04565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BM524_04570 ENOG4105C5E polysaccharide biosynthesis protein BM524_04585 ENOG4105KPE licD family BM524_04590 ENOG4105D2T synthase BM524_04600 ENOG4105F0R Cytidylyltransferase BM524_04610 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BM524_04620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_04625 ENOG4105BZU Histidine kinase BM524_04630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_04635 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BM524_04640 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BM524_04645 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BM524_04655 ENOG4108JIR Flagellum-specific ATP synthase BM524_04675 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BM524_04680 ENOG4105DD5 Flagellar motor switch protein BM524_04685 ENOG4105VTB flagellar biosynthesis protein fliO BM524_04690 ENOG4105CN7 Flagellar biosynthetic protein FliP BM524_04695 ENOG4105VS8 Flagellar biosynthetic protein fliq BM524_04700 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BM524_04705 ENOG4105D00 flagellar biosynthetic protein flhB BM524_04710 ENOG4105D7B Flagellar biosynthesis protein flha BM524_04715 ENOG4105FZW flagellar biosynthesis regulator FlhF BM524_04725 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_04730 ENOG4108VYJ response regulator receiver protein BM524_04735 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BM524_04740 ENOG4105CBS Chea signal transduction histidine kinase BM524_04750 ENOG4107QJE Chromosome Partitioning Protein BM524_04760 ENOG4105YFD chemotaxis, protein BM524_04770 ENOG4105CVG Homoserine O-transsuccinylase BM524_04775 ENOG4105C3R Methionine synthase BM524_04780 ENOG4105C3R Methionine synthase BM524_04790 ENOG4105NBK UPF0345 protein BM524_04795 ENOG4105C8Q Methyl-accepting chemotaxis BM524_04800 ENOG4105DZ2 Transcriptional regulator BM524_04805 ENOG4105C5Q Transcriptional regulator BM524_04810 ENOG4107B2H carbonic anhydrase BM524_04815 ENOG4105CHH sulfate transporter BM524_04830 ENOG4105C9K Endothelin-converting enzyme 1 BM524_04840 ENOG4108004 Modulates RecA activity (By similarity) BM524_04845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BM524_04850 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BM524_04875 ENOG4107QSA Oxaloacetate decarboxylase BM524_04880 ENOG4105D9Q decarboxylase (Beta subunit) BM524_04885 ENOG4108JQ2 peptide transport system atp-binding protein BM524_04890 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BM524_04895 ENOG4108EU3 peptide transport system, permease BM524_04900 ENOG4108I5W peptide transport system, permease protein BM524_04905 ENOG4105DEF Extracellular solute-binding protein, family 5 BM524_04910 ENOG4105E51 psp operon transcriptional activator BM524_04915 ENOG41087YS Phage shock protein A BM524_04930 ENOG4105MIR Phenylalanine 4-monooxygenase BM524_04945 ENOG4108RXX maleylacetoacetate isomerase BM524_04950 ENOG4108XM1 transcriptional regulator AsnC family BM524_04970 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BM524_04975 ENOG4108KPZ tonB-dependent Receptor BM524_05025 ENOG4109015 Biopolymer transport protein exbD tolR BM524_05030 ENOG410822N TonB family BM524_05040 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BM524_05080 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BM524_05095 ENOG4105HEI LysR family (Transcriptional regulator BM524_05100 ENOG4105F27 Major Facilitator BM524_05110 ENOG4105CV8 reductase BM524_05130 ENOG4107MII Sugar-specific transcriptional regulator TrmB BM524_05135 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BM524_05140 ENOG4105C75 arginyL-tRNA synthetase BM524_05190 ENOG4105F57 Anthranilate dioxygenase reductase BM524_05200 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BM524_05205 ENOG4105CRK lysyL-tRNA synthetase BM524_05215 ENOG4108W1A pseudouridine synthase BM524_05230 ENOG4105D9M gamma-glutamylcysteine synthetase BM524_05250 ENOG4108DG9 Smr protein MutS2 BM524_05255 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BM524_05260 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BM524_05270 ENOG4105ED1 spovr family BM524_05275 ENOG4106AKX UPF0229 protein BM524_05280 ENOG4105CYN Serine protein kinase BM524_05285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BM524_05290 ENOG4105M2J Glutaredoxin BM524_05295 ENOG4105D05 Receptor BM524_05320 ENOG4105D3R alkyl hydroperoxide reductase BM524_05325 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BM524_05330 ENOG4105EIY sodium-type flagellar protein motY BM524_05335 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BM524_05340 ENOG4108UYE Lactoylglutathione lyase BM524_05345 ENOG4105VEQ Cold shock protein BM524_05370 ENOG4105DZB Electron transport complex BM524_05375 ENOG4108UQQ Electron transport complex BM524_05380 ENOG4105D6A Electron transport complex BM524_05390 ENOG4108R3D Electron transport complex BM524_05395 ENOG4105DGN Electron transport complex BM524_05410 ENOG4107QJQ Mate efflux family protein BM524_05415 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BM524_05425 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BM524_05430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BM524_05440 ENOG4105CAQ asparagine synthetase BM524_05470 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BM524_05475 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BM524_05480 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BM524_05485 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BM524_05490 ENOG4105CK7 Sodium proline symporter BM524_05520 ENOG4107QVM von Willebrand factor, type A BM524_05540 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BM524_05545 ENOG4105CHU acetyl-coa acetyltransferase BM524_05550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BM524_05560 ENOG4105BZU Histidine kinase BM524_05570 ENOG4108BY2 phosphohistidine phosphatase BM524_05580 ENOG4108JU6 CBS domain protein BM524_05585 ENOG4106KVJ cytochrome C assembly protein BM524_05590 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BM524_05635 ENOG4105ENT Efflux transporter rnd family, mfp subunit BM524_05640 ENOG4105BZ1 (ABC) transporter BM524_05655 ENOG4105K5M 30s ribosomal protein S16 BM524_05660 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BM524_05665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BM524_05670 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BM524_05675 ENOG4105EN6 Membrane BM524_05680 ENOG4105E39 Enoyl-CoA hydratase BM524_05685 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BM524_05705 ENOG4108ZJT translation initiation factor, Sui1 BM524_05715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BM524_05725 ENOG4105BZU Histidine kinase BM524_05735 ENOG4107WP9 Histidine kinase BM524_05745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_05750 ENOG4105I03 Flagellin BM524_05765 ENOG4105C9M aspartyl-trna synthetase BM524_05770 ENOG4108TIT dATP pyrophosphohydrolase BM524_05775 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BM524_05780 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BM524_05785 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BM524_05790 ENOG4107YD3 Thioesterase BM524_05795 ENOG4105E02 MotA TolQ exbB proton channel BM524_05800 ENOG4105M8F Biopolymer transport protein exbD tolR BM524_05810 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BM524_05815 ENOG4105KCK Peptidoglycan-associated lipoprotein BM524_05820 ENOG4105UFD tol-pal system protein YbgF BM524_05840 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BM524_05855 ENOG4108NRW Phospholipase, patatin family BM524_05860 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BM524_05885 ENOG4108W6C Dehydrogenase BM524_05890 ENOG4105DS1 cytochrome b561 BM524_05905 ENOG4105BZU Histidine kinase BM524_05920 ENOG4105HEI LysR family (Transcriptional regulator BM524_05925 ENOG4105DQ4 alcohol dehydrogenase BM524_05930 ENOG4108VKG metal-dependent hydrolase BM524_05935 ENOG4105W87 Cbs domain BM524_05940 ENOG4105BZS acriflavin resistance protein BM524_05950 ENOG4108XG4 DNA-binding transcriptional regulator BM524_05955 ENOG4108ESX Receptor BM524_05975 ENOG4105BZU Histidine kinase BM524_05985 ENOG4105DY2 Paraquat-inducible protein b BM524_05990 ENOG4105F1S paraquat-inducible protein a BM524_06005 ENOG4105EMU Dehydrogenase BM524_06010 ENOG4105CF7 AraC family transcriptional regulator BM524_06015 ENOG4105C5S asparaginyl-tRNA synthetase BM524_06030 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BM524_06050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BM524_06055 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BM524_06060 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BM524_06065 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BM524_06070 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BM524_06075 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) BM524_06080 ENOG4105KJF protein tyrosine phosphatase BM524_06085 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) BM524_06090 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) BM524_06095 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BM524_06110 ENOG4108JJ7 ABC transporter BM524_06115 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BM524_06125 ENOG4105XJC Two component transcriptional regulator (Winged helix family BM524_06145 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BM524_06180 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BM524_06195 ENOG4108UJV acyl-CoA thioesterase i BM524_06200 ENOG4108I0Y (ABC) transporter BM524_06205 ENOG4105CV6 ABC transporter, permease BM524_06210 ENOG4105ECP epimerase BM524_06215 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase BM524_06220 ENOG4105DSF transport protein BM524_06230 ENOG4105XJC Two component transcriptional regulator (Winged helix family BM524_06245 ENOG4105K9H YciI-like protein BM524_06250 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BM524_06255 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BM524_06260 ENOG4105DK0 Indole-3-glycerol phosphate synthase BM524_06265 ENOG4108I0Q anthranilate phosphoribosyltransferase BM524_06275 ENOG4105CRQ synthase (Component I) BM524_06280 ENOG4105DB7 PHP domain protein BM524_06285 ENOG4107RTD sua5 ycio yrdc ywlc family protein BM524_06290 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BM524_06295 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BM524_06300 ENOG4105FE9 pseudouridine synthase BM524_06305 ENOG4105CV8 reductase BM524_06310 ENOG4108UW5 maltose o-acetyltransferase BM524_06320 ENOG4106BRA Membrane BM524_06335 ENOG4108JJ6 Type I secretion system ATPase BM524_06345 ENOG4105FQ6 thiopurine methyltransferase BM524_06350 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BM524_06355 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BM524_06360 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BM524_06365 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BM524_06370 ENOG4105C0A alcohol dehydrogenase BM524_06375 ENOG4105DTD Dehydrogenase BM524_06385 ENOG4105DWV Homoserine O-trans-acetylase BM524_06390 ENOG4105CY2 Citrate transporter BM524_06410 ENOG4105BZU Histidine kinase BM524_06430 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BM524_06435 ENOG4105CFG Acts as a chaperone (By similarity) BM524_06440 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BM524_06445 ENOG41085AF Cytochrome BM524_06455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BM524_06465 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BM524_06470 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BM524_06475 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BM524_06480 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BM524_06500 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BM524_06505 ENOG4105C6K Malic enzyme BM524_06510 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BM524_06515 ENOG4108JU5 Magnesium and cobalt efflux protein BM524_06520 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BM524_06525 ENOG4105C9A Phoh family BM524_06530 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BM524_06535 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BM524_06560 ENOG4107RNH Outer membrane receptor FepA BM524_06565 ENOG4108S4H thioesterase Superfamily protein BM524_06570 ENOG4107XWI flavin reductase domain protein, FMN-binding BM524_06580 ENOG4105BZG amino acid carrier protein BM524_06625 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BM524_06630 ENOG4105C3G gtp-binding protein BM524_06635 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BM524_06640 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BM524_06645 ENOG4105DQ4 alcohol dehydrogenase BM524_06660 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BM524_06670 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BM524_06675 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BM524_06680 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BM524_06685 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BM524_06690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BM524_06695 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_06700 ENOG4108YY7 Invasion gene expression up-regulator SirB BM524_06705 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BM524_06715 ENOG4105ETT transcriptional Regulator, LysR family BM524_06725 ENOG4105M08 Membrane BM524_06730 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) BM524_06735 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BM524_06740 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BM524_06745 ENOG4107TPY serine threonine protein kinase BM524_06750 ENOG4105TMB Formate nitrite transporter BM524_06755 ENOG4105F8C transglutaminase domain-containing protein BM524_06765 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BM524_06770 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BM524_06775 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BM524_06780 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BM524_06785 ENOG4105BZU Histidine kinase BM524_06790 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) BM524_06800 ENOG4105K8R UPF0145 protein BM524_06820 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BM524_06825 ENOG4105KUZ arsenate reductase BM524_06830 ENOG4107RBJ symporter BM524_06850 ENOG4105F1J Homogentisate 1,2-dioxygenase BM524_06880 ENOG4108HKT sucrose-6-phosphate hydrolase BM524_06890 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BM524_06895 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_06900 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BM524_06930 ENOG4108XHQ (2Fe-2S)-binding domain protein BM524_06940 ENOG4107R1I NAD-dependent malic enzyme BM524_06945 ENOG4105BZU Histidine kinase BM524_06950 ENOG4105BZU Histidine kinase BM524_06970 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BM524_06995 ENOG4105BZU Histidine kinase BM524_07005 ENOG4107QUY Guanine deaminase BM524_07025 ENOG4105C7W Xanthine dehydrogenase BM524_07040 ENOG4108R86 Transcriptional regulator BM524_07055 ENOG4105C7N Xanthine uracil vitamin C permease BM524_07060 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BM524_07070 ENOG4105BZU Histidine kinase BM524_07080 ENOG4105BZU Histidine kinase BM524_07095 ENOG4105C2W permease BM524_07110 ENOG4105C5R Aminotransferase BM524_07115 ENOG4105HF0 Membrane BM524_07120 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BM524_07155 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BM524_07165 ENOG4105C22 threonyL-tRNA synthetase BM524_07170 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BM524_07175 ENOG41082NX 50s ribosomal protein l35 BM524_07180 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BM524_07185 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BM524_07190 ENOG4105D3Q Sugar transferase BM524_07200 ENOG4105DAY polysaccharide export protein BM524_07205 ENOG4108QV3 biosynthesis protein BM524_07210 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BM524_07235 ENOG4105BZU Histidine kinase BM524_07260 ENOG4105K64 Glycosyl transferase, family 2 BM524_07280 ENOG4108SHN Glycosyl transferase, family 2 BM524_07285 ENOG4107T8Q Glycosyl transferase (Group 1 BM524_07295 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family BM524_07310 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BM524_07315 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BM524_07320 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BM524_07340 ENOG4108Z66 YbaK ebsC protein BM524_07350 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BM524_07355 ENOG4108WBT adenosyltransferase BM524_07365 ENOG4108JA2 transcriptioN-repair coupling factor BM524_07375 ENOG4105D60 lipoprotein releasing system transmembrane protein BM524_07400 ENOG4105CGK Exodeoxyribonuclease III BM524_07435 ENOG4105DNH Major Facilitator BM524_07445 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BM524_07465 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BM524_07475 ENOG4108UKI Enoyl-CoA hydratase BM524_07480 ENOG4107QX3 carboxylase BM524_07485 ENOG4105C1G acyl-Coa dehydrogenase BM524_07490 ENOG4108Z6Z Transcriptional regulator BM524_07495 ENOG4105CHU acetyl-coa acetyltransferase BM524_07510 ENOG4105BZU Histidine kinase BM524_07520 ENOG4105CJB Exodeoxyribonuclease I BM524_07525 ENOG4105BZU Histidine kinase BM524_07530 ENOG4105D44 asparaginase BM524_07570 ENOG4105CQ7 ATP-dependent helicase BM524_07585 ENOG4105DR4 Methyltransferase BM524_07590 ENOG4108JA1 polyketide synthase BM524_07595 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BM524_07600 ENOG4107RZZ dna polymerase iii epsilon subunit BM524_07630 ENOG4108M8H domain protein BM524_07640 ENOG4105D60 lipoprotein releasing system transmembrane protein BM524_07645 ENOG4105CK2 sodium dicarboxylate symporter BM524_07655 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) BM524_07665 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BM524_07680 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BM524_07685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BM524_07690 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit BM524_07695 ENOG4107YB6 acetyltransferase, (GNAT) family BM524_07710 ENOG4105C03 ribonuclease BM524_07715 ENOG4105EI2 Pseudouridine synthase BM524_07730 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BM524_07735 ENOG4105VGS 50s ribosomal protein l32 BM524_07740 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BM524_07745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BM524_07750 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BM524_07755 ENOG4105CHR reductase BM524_07760 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BM524_07765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BM524_07775 ENOG4105HHA aminodeoxychorismate lyase BM524_07780 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BM524_07785 ENOG4107QRG dna polymerase iii BM524_07790 ENOG4105F8V Hydrolase, tatD family BM524_07805 ENOG4105BZU Histidine kinase BM524_07825 ENOG4105CHR reductase BM524_07830 ENOG4108J2P Alpha beta hydrolase fold BM524_07840 ENOG4105CHU acetyl-coa acetyltransferase BM524_07845 ENOG4105CSU acyl-Coa dehydrogenase BM524_07860 ENOG4105DKT Transcriptional regulator BM524_07865 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 BM524_07875 ENOG4105DEI Mannitol dehydrogenase BM524_07900 ENOG4105D8X mechanosensitive ion channel BM524_07905 ENOG4105D05 Receptor BM524_07910 ENOG4105KZX Pterin carbinolamine dehydratase BM524_07930 ENOG4105BZU Histidine kinase BM524_07935 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_07940 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BM524_07945 ENOG4105CHV Transcription elongation factor NusA BM524_07950 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BM524_07955 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BM524_07960 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BM524_07970 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BM524_07975 ENOG4105BZU Histidine kinase BM524_07980 ENOG4105FE9 pseudouridine synthase BM524_07990 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BM524_08020 ENOG4105D3R alkyl hydroperoxide reductase BM524_08065 ENOG4105CCT upf0313 protein BM524_08080 ENOG4105D05 Receptor BM524_08085 ENOG4107QN2 dihydrolipoyl dehydrogenase BM524_08095 ENOG4105VNH ABC transporter solute-binding protein BM524_08105 ENOG4108VGW abc transporter atp-binding protein BM524_08110 ENOG4108T9J Cdp-alcohol phosphatidyltransferase BM524_08150 ENOG4105CBN LysR family transcriptional regulator BM524_08170 ENOG4105CJ1 ABC, transporter BM524_08185 ENOG4105DMT epimerase dehydratase BM524_08190 ENOG4105C09 Bile acid BM524_08215 ENOG410679B prophage CP4-57 regulatory protein alpA BM524_08245 ENOG4105DFP Integrase BM524_08255 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BM524_08260 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BM524_08265 ENOG4108Z1B Cyclase dehydrase BM524_08270 ENOG4105VDB UPF0125 protein BM524_08280 ENOG4105C94 Transporter BM524_08285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_08290 ENOG4107RDJ Sulfotransferase BM524_08300 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BM524_08305 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BM524_08340 ENOG4105EZE Cupin 4 family protein BM524_08355 ENOG4107QTF adenylosuccinate lyase BM524_08360 ENOG41075W9 High frequency lysogenization protein HflD homolog BM524_08365 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BM524_08370 ENOG4108R99 pseudouridine synthase BM524_08375 ENOG4105E9K Isocitrate dehydrogenase BM524_08380 ENOG4105VEQ Cold shock protein BM524_08385 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BM524_08390 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BM524_08395 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BM524_08400 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate BM524_08405 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BM524_08410 ENOG4105C3M thioredoxin reductase BM524_08415 ENOG4105PQ6 UPF0208 membrane protein BM524_08420 ENOG4105GPY SprT protein BM524_08425 ENOG4105D07 Signal peptide peptidase, SppA BM524_08440 ENOG41069NU Nitroreductase BM524_08450 ENOG4105HDK L-asparaginase BM524_08455 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BM524_08460 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BM524_08465 ENOG4108Z43 UPF0250 protein BM524_08470 ENOG4105DZ1 carboxypeptidase BM524_08475 ENOG4105K6T rare lipoprotein A BM524_08480 ENOG4105CNI cell division protein FtsW BM524_08485 ENOG4105CJN penicillin-binding protein BM524_08490 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BM524_08495 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BM524_08505 ENOG4105DJF DNA polymerase III, delta' subunit BM524_08510 ENOG4108U2H Rare lipoprotein B BM524_08515 ENOG4105C8T Leucyl-tRNA synthetase BM524_08525 ENOG4105DAN ATP-dependent protease BM524_08530 ENOG4107R6F Alpha Beta Hydrolase Fold protein BM524_08535 ENOG4105BZU Histidine kinase BM524_08545 ENOG4105HBR Rna-binding protein BM524_08550 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BM524_08555 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BM524_08560 ENOG4105EEI dihydropteroate synthase BM524_08565 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BM524_08570 ENOG4105CP7 Triose-phosphate isomerase BM524_08585 ENOG4105BZU Histidine kinase BM524_08615 ENOG4105CHR reductase BM524_08620 ENOG4108KP7 hydrolase BM524_08635 ENOG4105CK7 Sodium proline symporter BM524_08645 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BM524_08660 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BM524_08705 ENOG4105JAB phenazine biosynthesis protein, phzf family BM524_08790 ENOG410822N TonB family BM524_08820 ENOG4105EXN Sulfate transport protein CysZ BM524_08825 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BM524_08830 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) BM524_08835 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BM524_08850 ENOG4105BZ1 (ABC) transporter BM524_08855 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BM524_08860 ENOG4105W49 UPF0434 protein BM524_08865 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BM524_08880 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BM524_08895 ENOG4105CUZ uba thif-type nad fad binding protein BM524_08900 ENOG4105CHF Glutathione S-transferase BM524_08905 ENOG4105EUB pirin domain protein BM524_08910 ENOG4107QKV phosphomannomutase BM524_08920 ENOG4105BZN citrate synthase BM524_08925 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BM524_08930 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BM524_08935 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BM524_08940 ENOG4105E33 succinate dehydrogenase BM524_08945 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BM524_08950 ENOG4105C7S Dehydrogenase BM524_08955 ENOG4105CMV Succinyl-CoA synthetase subunit beta BM524_08960 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BM524_08975 ENOG4105QV4 Tryptophan halogenase BM524_08990 ENOG4108NRW Phospholipase, patatin family BM524_09010 ENOG4108IUK alpha amylase, catalytic BM524_09025 ENOG4105ETE Transcriptional regulator (LacI family BM524_09030 ENOG4105CX6 glutaminyL-tRNA synthetase BM524_09035 ENOG4105UBK short-chain dehydrogenase reductase BM524_09040 ENOG4108M0H Extracellular lipase BM524_09045 ENOG4107SQI penicillin amidase BM524_09050 ENOG4105ERU peptidase BM524_09065 ENOG4107QNR UPF0135 protein BM524_09070 ENOG4106371 Methyltransferase BM524_09075 ENOG4105C5I Dehydrogenase BM524_09080 ENOG4108V06 Glutathione peroxidase BM524_09085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BM524_09095 ENOG4105C1G acyl-Coa dehydrogenase BM524_09100 ENOG4105E39 Enoyl-CoA hydratase BM524_09105 ENOG4105DHI Methyltransferase BM524_09110 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BM524_09115 ENOG4105E68 Sulfatase BM524_09120 ENOG4105YDX UPF0352 protein BM524_09125 ENOG4106V8H Nucleoid-associated protein BM524_09155 ENOG4108HRK Histidine kinase BM524_09160 ENOG4108VAC response regulator BM524_09165 ENOG4105CTQ phosphohexokinase BM524_09175 ENOG4105W1Y Transcriptional regulator BM524_09190 ENOG4105PGM cation diffusion facilitator family transporter BM524_09225 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BM524_09235 ENOG4105C72 UPF0176 protein BM524_09245 ENOG4105C1J atp-dependent rna helicase BM524_09255 ENOG4105D6N CoA-transferase, subunit a BM524_09260 ENOG4105F04 LysR family Transcriptional regulator BM524_09275 ENOG4107R11 Transcriptional regulator BM524_09280 ENOG4105EJQ L-serine dehydratase BM524_09290 ENOG4105CRQ synthase (Component I) BM524_09305 ENOG4105CGY Dna recombination protein BM524_09310 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BM524_09320 ENOG4105CPP Dehydrogenase, E1 component BM524_09330 ENOG4105D6S protein involved in catabolism of external DNA BM524_09340 ENOG4105C29 acyl-CoA thioesterase BM524_09345 ENOG4108Z0R Transferase BM524_09350 ENOG4105C5R Aminotransferase BM524_09360 ENOG4108ZGC gaf domain protein BM524_09370 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BM524_09375 ENOG4105CN1 protease BM524_09380 ENOG4105C8J )-transporter BM524_09385 ENOG4105DFD Na H antiporter BM524_09390 ENOG4105CD8 aminopeptidase N BM524_09405 ENOG4105D25 secreted protein BM524_09420 ENOG4105C7I Dehydrogenase BM524_09425 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BM524_09430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BM524_09440 ENOG4105C5H ABC transporter BM524_09450 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) BM524_09455 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BM524_09465 ENOG4105CVP deoxyribo-dipyrimidine photolyase BM524_09470 ENOG4105CVP deoxyribo-dipyrimidine photolyase BM524_09475 ENOG4105CVP deoxyribo-dipyrimidine photolyase BM524_09480 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein BM524_09495 ENOG4105DUU IucA IucC family protein BM524_09500 ENOG4107F3J Amp-dependent synthetase and ligase BM524_09505 ENOG41086VD Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BM524_09510 ENOG4108WBH protein TIM barrel BM524_09540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BM524_09550 ENOG41080IJ Diacylglycerol kinase BM524_09555 ENOG41081QV Universal stress protein BM524_09565 ENOG4105CBC glutamate synthase BM524_09570 ENOG4105CKD glutathione-regulated potassium-efflux system protein BM524_09575 ENOG4108UQY Iron-storage protein BM524_09590 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BM524_09605 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) BM524_09630 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BM524_09635 ENOG4105Q9Y Universal stress protein BM524_09640 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BM524_09645 ENOG4105D78 K07001 NTE family protein BM524_09670 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BM524_09675 ENOG4105KHC sulfurtransferase BM524_09680 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BM524_09685 ENOG4106IUH DTW domain containing protein BM524_09710 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BM524_09715 ENOG4105WH1 Two component transcriptional regulator luxr family BM524_09720 ENOG4105CHM Aminotransferase BM524_09725 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process BM524_09740 ENOG4105CC0 LysR family Transcriptional regulator BM524_09745 ENOG4108VGI doxx family BM524_09755 ENOG4108MN8 Membrane BM524_09760 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BM524_09775 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BM524_09805 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_09805 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_09810 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BM524_09815 ENOG4105WMR Protein CrcB homolog BM524_09820 ENOG4105D1H recombination factor protein RarA BM524_09830 ENOG4105CNU cell division protein FtsK BM524_09835 ENOG4105EW9 transcriptional regulator AsnC family BM524_09840 ENOG4105DCF alanine dehydrogenase BM524_09845 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BM524_09850 ENOG4105CFV Tetratricopeptide repeat protein BM524_09865 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BM524_09870 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BM524_09875 ENOG4105CAT Cytidine monophosphate kinase BM524_09880 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BM524_09885 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BM524_09890 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_09895 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BM524_09900 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BM524_09905 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BM524_09910 ENOG4105XPH Ferredoxin BM524_09930 ENOG4105BZU Histidine kinase BM524_09940 ENOG4105C8V SAICAR synthetase BM524_09945 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BM524_09950 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BM524_09960 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BM524_09970 ENOG4105ERG peptidase m48, ste24p BM524_09980 ENOG4105K89 arsenate reductase BM524_09985 ENOG4105CS1 NAD(P)H quinone oxidoreductase BM524_09995 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BM524_10005 ENOG4105CXB phosphoribosylaminoimidazole synthetase BM524_10010 ENOG4108V3E phosphoribosylglycinamide formyltransferase BM524_10020 ENOG4107QPN acyl-Coa dehydrogenase BM524_10035 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BM524_10040 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BM524_10045 ENOG4105DBI uridine monophosphokinase BM524_10050 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase BM524_10055 ENOG4105C3Q Glycosyl transferase, family 2 BM524_10060 ENOG4107QW3 Sucrose phosphorylase BM524_10065 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BM524_10070 ENOG4105CVM Molybdenum cofactor synthesis domain protein BM524_10075 ENOG4107QI1 Mate efflux family protein BM524_10095 ENOG4105C6T cysteine synthase BM524_10150 ENOG4105JAB phenazine biosynthesis protein, phzf family BM524_10155 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BM524_10160 ENOG41060WC Enoyl-CoA hydratase BM524_10180 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BM524_10190 ENOG4105C28 cystathionine BM524_10205 ENOG4105CGF Aromatic amino acid aminotransferase BM524_10220 ENOG4108UPT UPF0178 protein BM524_10225 ENOG4105CHR reductase BM524_10230 ENOG4105CHR reductase BM524_10235 ENOG4105CSU acyl-Coa dehydrogenase BM524_10240 ENOG4105FTV AraC Family Transcriptional Regulator BM524_10265 ENOG4105ENT Efflux transporter rnd family, mfp subunit BM524_10275 ENOG4105C10 Electron transfer flavoprotein BM524_10280 ENOG4105BZJ Electron transfer flavoprotein BM524_10285 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BM524_10290 ENOG4108YX2 DNA-binding protein BM524_10295 ENOG4105EV9 Alpha Beta Hydrolase BM524_10305 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BM524_10310 ENOG4108NVR Methyl-accepting chemotaxis BM524_10315 ENOG41090R7 Ferric uptake BM524_10330 ENOG4105P4J Allophanate hydrolase, subunit 1 BM524_10335 ENOG4105E7W lamb ycsf family protein BM524_10340 ENOG4105QNR S1 RNA binding domain protein BM524_10345 ENOG4108UKZ OsmC family BM524_10350 ENOG4105ENT Efflux transporter rnd family, mfp subunit BM524_10375 ENOG4105CHM Aminotransferase BM524_10380 ENOG4105DK2 UPF0207 protein BM524_10385 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BM524_10410 ENOG4105K5B UPF0225 protein BM524_10415 ENOG4105BZU Histidine kinase BM524_10430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BM524_10440 ENOG4105C1G acyl-Coa dehydrogenase BM524_10450 ENOG4107ZSV Receptor BM524_10470 ENOG4105D4P Coproporphyrinogen iii oxidase BM524_10475 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BM524_10480 ENOG4105E0C molybdate abc transporter BM524_10490 ENOG4108ZAF Molybdopterin BM524_10495 ENOG4105M00 molybdopterin converting factor, subunit 1 BM524_10500 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BM524_10505 ENOG4108RIR Molybdenum cofactor biosynthesis protein BM524_10510 ENOG4105D06 uba thif-type nad fad binding protein BM524_10525 ENOG4105KRQ Addiction module toxin, Txe YoeB family BM524_10545 ENOG4105EG6 Saccharopine dehydrogenase BM524_10550 ENOG4105CIH Imidazole acetol-phosphate transaminase BM524_10565 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BM524_10570 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_10580 ENOG4107AQZ Membrane BM524_10605 ENOG4107QYX exodeoxyribonuclease v alpha BM524_10610 ENOG4107QKA exodeoxyribonuclease V beta BM524_10615 ENOG4105DSY exodeoxyribonuclease V, gamma BM524_10625 ENOG4108IQE Amp-dependent synthetase and ligase BM524_10650 ENOG4105CVI Transcriptional regulator BM524_10665 ENOG41082SX arsR family transcriptional regulator BM524_10675 ENOG4105DUM transcriptional regulator, lysR family BM524_10685 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_10730 ENOG4105DK2 UPF0207 protein BM524_10755 ENOG4105VUT cytoplasmic protein BM524_10770 ENOG4105BZG amino acid carrier protein BM524_10790 ENOG4105E0X reductase BM524_10795 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BM524_10805 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BM524_10810 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BM524_10815 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BM524_10820 ENOG4105DSB aldose 1-epimerase BM524_10825 ENOG4108UHU Aldolase BM524_10830 ENOG4105CHC glucokinase (EC 2.7.1.2) BM524_10835 ENOG4105C01 Dihydroxy-acid dehydratase BM524_10840 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) BM524_10845 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BM524_10850 ENOG4106KNT transcriptional regulator BM524_10855 ENOG4105CA9 Pyruvate kinase BM524_10860 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BM524_10875 ENOG4105K3G Periplasmic Protein BM524_10905 ENOG4105EIG urea carboxylase-associated protein 1 BM524_10925 ENOG4105CHR reductase BM524_10935 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BM524_10940 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BM524_10945 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BM524_10950 ENOG4105ETE Transcriptional regulator (LacI family BM524_10955 ENOG4105CTX dehydratase BM524_10960 ENOG4105D2H Uronic isomerase BM524_10965 ENOG4105DEI Mannitol dehydrogenase BM524_10970 ENOG4108UHU Aldolase BM524_10975 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BM524_10980 ENOG4107TDE lipolytic protein G-D-S-L family BM524_10990 ENOG4107XII Glycosyl Hydrolase Family 88 BM524_11000 ENOG4105BZU Histidine kinase BM524_11015 ENOG4108K8S endonuclease I BM524_11020 ENOG4105C8Q Methyl-accepting chemotaxis BM524_11035 ENOG4108W5M transcriptional regulator BM524_11040 ENOG4108I6A alcohol dehydrogenase BM524_11055 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_11060 ENOG4105BZU Histidine kinase BM524_11075 ENOG4105C8P )-transporter BM524_11080 ENOG4105DHP deoxycytidine triphosphate deaminase BM524_11085 ENOG4105D1F ATP-binding protein BM524_11090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BM524_11100 ENOG4105D1A Methyltransferase BM524_11105 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BM524_11110 ENOG4105E9H Lytic Murein transglycosylase BM524_11120 ENOG4105C8N cysteinyl-tRNA synthetase BM524_11125 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BM524_11130 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BM524_11140 ENOG4107S78 Band 7 protein BM524_11155 ENOG4105KVH Transcriptional regulator BM524_11170 ENOG4105CIS alcohol dehydrogenase BM524_11190 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BM524_11200 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BM524_11205 ENOG4105E96 Colicin v production protein BM524_11210 ENOG4108S3P Sporulation domain protein BM524_11215 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BM524_11220 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BM524_11235 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BM524_11240 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BM524_11245 ENOG4105MP9 class II Aldolase BM524_11260 ENOG4105YAJ CopG Arc MetJ BM524_11270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BM524_11285 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BM524_11315 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BM524_11340 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BM524_11345 ENOG4105DKW ABC transporter BM524_11350 ENOG4105CRW Short chain fatty acid transporter BM524_11355 ENOG4105BZU Histidine kinase BM524_11380 ENOG4108BPE -transporting atpase BM524_11405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BM524_11430 ENOG4105D8T Acyltransferase BM524_11440 ENOG4108UH6 UPF0754 membrane protein BM524_11465 ENOG4105CUG Oligopeptidase b BM524_11470 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BM524_11475 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BM524_11480 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BM524_11485 ENOG4108428 Inherit from COG: -acetyltransferase BM524_11495 ENOG4108ZZ3 UPF0260 protein BM524_11500 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BM524_11510 ENOG4105VNG YcgL domain-containing protein BM524_11515 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BM524_11520 ENOG4105CEY Amp-dependent synthetase and ligase BM524_11525 ENOG410832A alpha/beta hydrolase fold BM524_11540 ENOG41072GX Peptidase M22 Glycoprotease BM524_11545 ENOG4105DVT helicase BM524_11600 ENOG4107T8T UPF0173 metal-dependent hydrolase BM524_11605 ENOG4105D05 Receptor BM524_11615 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BM524_11620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BM524_11625 ENOG4105CIH Imidazole acetol-phosphate transaminase BM524_11630 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BM524_11640 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BM524_11645 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BM524_11650 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BM524_11655 ENOG4105S64 Formate nitrite transporter BM524_11660 ENOG4108NVR Methyl-accepting chemotaxis BM524_11685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BM524_11690 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BM524_11695 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BM524_11705 ENOG4105BZU Histidine kinase BM524_11710 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BM524_11715 ENOG4107QMP dna polymerase iii subunits gamma and tau BM524_11720 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BM524_11730 ENOG4105E18 UPF0276 protein BM524_11780 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BM524_11800 ENOG4105CXG d-lactate dehydrogenase BM524_11805 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BM524_11810 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BM524_11815 ENOG4105C34 Pseudouridine synthase BM524_11820 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BM524_11830 ENOG4105K6V RNA polymerase BM524_11845 ENOG4105EMU Dehydrogenase BM524_11860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BM524_11865 ENOG4106VK6 Flagellar motor protein BM524_11870 ENOG4105E14 MotA TolQ exbB proton channel BM524_11880 ENOG4105CTB Polyprenyl synthetase BM524_11885 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BM524_11890 ENOG4108ZAI phosphatidylglycerophosphatase a BM524_11895 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BM524_11900 ENOG4107YIM Involved in the transcription termination process (By similarity) BM524_11905 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BM524_11920 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BM524_11925 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BM524_11930 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BM524_11935 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BM524_11940 ENOG4105C5H ABC transporter BM524_11950 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BM524_11960 ENOG4105EAC phosphoserine phosphatase BM524_11970 ENOG4105EYA deoxyribonuclease BM524_11975 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BM524_11980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BM524_11985 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BM524_11990 ENOG4105C3F Signal peptidase i BM524_11995 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BM524_12015 ENOG4105EMN RNA polymerase sigma factor BM524_12020 ENOG4108IYU L-aspartate oxidase BM524_12035 ENOG4105Y75 tpr repeat protein BM524_12040 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BM524_12045 ENOG4108YZY peptidylprolyl cis-trans isomerase BM524_12050 ENOG4108YZA Nitrogen regulatory protein pii BM524_12055 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BM524_12115 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BM524_12120 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BM524_12125 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BM524_12130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BM524_12135 ENOG4105DTN riboflavin biosynthesis protein ribF BM524_12140 ENOG4105CJR Integral membrane protein (MviN BM524_12145 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BM524_12160 ENOG4105CHR reductase BM524_12165 ENOG4105C09 Bile acid BM524_12170 ENOG4108PTX LysR family Transcriptional regulator BM524_12190 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BM524_12200 ENOG4105EIN peptidylprolyl cis-trans isomerase BM524_12205 ENOG4105K70 DNA-binding protein BM524_12210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BM524_12215 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BM524_12220 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BM524_12225 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BM524_12255 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BM524_12265 ENOG4108R96 Methyltransferase, YaeB family BM524_12270 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BM524_12275 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BM524_12280 ENOG4105HDD phospholipase BM524_12285 ENOG4105DGU Histone deacetylase BM524_12290 ENOG4105C8Q Methyl-accepting chemotaxis BM524_12295 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BM524_12300 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BM524_12305 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BM524_12320 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BM524_12325 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BM524_12330 ENOG4105N21 Membrane BM524_12335 ENOG4105CUT histidyl-tRNA synthetase BM524_12340 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BM524_12355 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BM524_12360 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BM524_12365 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BM524_12375 ENOG4108Z4V iron-sulfur cluster assembly BM524_12380 ENOG4105C9B Cysteine desulfurase BM524_12385 ENOG4105JRK feS assembly protein SufD BM524_12390 ENOG4105C3K feS assembly ATPase SufC BM524_12400 ENOG4105C3J Cysteine desulfurase BM524_12405 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BM524_12410 ENOG4105CT3 Monooxygenase BM524_12415 ENOG4105D7W serine acetyltransferase BM524_12420 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BM524_12440 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BM524_12445 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BM524_12450 ENOG4105VIE preprotein translocase, subunit YajC BM524_12455 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BM524_12460 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BM524_12475 ENOG4108P9J Phage shock protein A BM524_12500 ENOG4106032 Glutathionylspermidine synthase BM524_12515 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BM524_12530 ENOG4105CSV Glutaminase BM524_12535 ENOG4105G6Z alkaline phosphatase BM524_12545 ENOG4107RET Isocitrate lyase BM524_12595 ENOG4105C0H protease BM524_12620 ENOG4107T8Q Glycosyl transferase (Group 1 BM524_12645 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BM524_12665 ENOG4107QPH glycogen) synthase BM524_12670 ENOG4105CAQ asparagine synthetase BM524_12680 ENOG41088M2 Glycosyl transferase family 2 BM524_12690 ENOG4105K64 Glycosyl transferase, family 2 BM524_12710 ENOG4105CAQ asparagine synthetase BM524_12730 ENOG4105D3Q Sugar transferase BM524_12745 ENOG4108QV3 biosynthesis protein BM524_12760 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BM524_12780 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BM524_12790 ENOG4105D1S lipid A biosynthesis BM524_12805 ENOG4107QPN acyl-Coa dehydrogenase BM524_12820 ENOG4105BZU Histidine kinase BM524_12825 ENOG4107104 thymidine kinase BM524_12840 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BM524_12870 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BM524_12875 ENOG4108RWN rrna methyltransferase BM524_12880 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BM524_12895 ENOG4105C26 Dehydrogenase BM524_12900 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BM524_12915 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) BM524_12920 ENOG4108Z4X TRANSCRIPTIONal BM524_12950 ENOG4105CSU acyl-Coa dehydrogenase BM524_12970 ENOG4105E3W Two component transcriptional regulator (Winged helix family BM524_12975 ENOG4105E0F Histidine kinase BM524_12985 ENOG4105NA0 Transcriptional regulator BM524_12990 ENOG410822N TonB family BM524_13005 ENOG4107XDR Lactoylglutathione lyase BM524_13015 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit BM524_13020 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding BM524_13025 ENOG4105C7W Xanthine dehydrogenase BM524_13045 ENOG4105CHR reductase BM524_13050 ENOG4105EMU Dehydrogenase BM524_13055 ENOG4107RKG DJ-1/PfpI family BM524_13060 ENOG4107U9T Pfam:Ribonuclease_BN BM524_13075 ENOG4108VWS Yaeq family BM524_13105 ENOG4105S8Q sugar efflux transporter BM524_13125 ENOG4105C9U ATP-dependent DNA helicase RecQ BM524_13145 ENOG4105BZU Histidine kinase BM524_13155 ENOG4105BZU Histidine kinase BM524_13160 ENOG4105D8V Glucose sorbosone dehydrogenase BM524_13165 ENOG4105YAJ CopG Arc MetJ BM524_13175 ENOG4105XJC Two component transcriptional regulator (Winged helix family BM524_13180 ENOG4105BZU Histidine kinase BM524_13230 ENOG4105F9F transposase BM524_13235 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BM524_13240 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BM524_13245 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BM524_13250 ENOG4105CE4 GlcNAc 6-P deacetylase BM524_13255 ENOG4105RD7 BadF BadG BcrA BcrD BM524_13265 ENOG4105DAA L-lactate BM524_13285 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BM524_13290 ENOG4105D0A hydroxylase BM524_13295 ENOG4107RAQ aminopeptidase BM524_13310 ENOG4108RVA ribokinase BM524_13325 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BM524_13330 ENOG4105E66 phosphoriboisomerase A BM524_13335 ENOG4108JQ1 Dehydrogenase BM524_13355 ENOG4105XZD Fe-S protein BM524_13390 ENOG4107QN2 dihydrolipoyl dehydrogenase BM524_13395 ENOG4107QSN dihydrolipoamide acetyltransferase BM524_13400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BM524_13405 ENOG41073TP transcriptional regulator BM524_13415 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BM524_13420 ENOG4108WIW Aspartyl protease BM524_13425 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BM524_13435 ENOG4105D7Q type ii secretion system BM524_13440 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BM524_13450 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) BM524_13455 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BM524_13460 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) BM524_13465 ENOG4105M6F mutator MutT protein BM524_13470 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BM524_13475 ENOG4105DR5 peptidase BM524_13480 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BM524_13485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BM524_13490 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BM524_13495 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BM524_13500 ENOG4105CPF Cell wall formation (By similarity) BM524_13505 ENOG4105DFU Cell wall formation (By similarity) BM524_13510 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BM524_13515 ENOG4105CNI cell division protein FtsW BM524_13520 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BM524_13525 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BM524_13530 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BM524_13535 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BM524_13540 ENOG4105CJN penicillin-binding protein BM524_13545 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BM524_13550 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BM524_13555 ENOG4108V6E Cell division protein mraZ BM524_13575 ENOG4108IJF Heavy metal efflux pump, CzcA BM524_13580 ENOG4105EP1 Efflux transporter rnd family, mfp subunit BM524_13600 ENOG4105EHV domain protein BM524_13615 ENOG4105BZU Histidine kinase BM524_13625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_13630 ENOG4105BZU Histidine kinase BM524_13640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BM524_13645 ENOG4105DPW Major facilitator superfamily MFS_1 BM524_13675 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BM524_13680 ENOG4105D7Z glutathione synthase BM524_13685 ENOG4108UJU UPF0301 protein BM524_13690 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BM524_13700 ENOG4105CZX twitching motility protein BM524_13705 ENOG4105CZX twitching motility protein BM524_13710 ENOG4105DFA alanine racemase domain protein BM524_13715 ENOG4105II7 pyrroline-5-carboxylate reductase BM524_13720 ENOG4108VIA integral membrane protein BM524_13730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BM524_13745 ENOG4108SHQ Glutathione S-transferase BM524_13750 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BM524_13755 ENOG4108Z9K Osmotically inducible protein BM524_13760 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BM524_13775 ENOG4108UMN azlc family BM524_13785 ENOG4105F27 Major Facilitator BM524_13790 ENOG4105VFU Rna-binding protein BM524_13795 ENOG4105D1Q UPF0246 protein BM524_13805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BM524_13810 ENOG4107QP8 phosphohexose isomerase BM524_13815 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BM524_13820 ENOG4105D98 threonine synthase BM524_13825 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BM524_13840 ENOG4105CC0 LysR family Transcriptional regulator BM524_13855 ENOG41082YX Transcriptional regulator, arsr family BM524_13865 ENOG4105CAU Arsenical resistance protein, ArsH BM524_13870 ENOG4105D6J arsenicaL-resistance protein BM524_13875 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BM524_13880 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) BM524_13890 ENOG4105BZU Histidine kinase BM524_13905 ENOG4105K6H D-cysteine desulfhydrase BM524_13935 ENOG4105E3Q saccharopine dehydrogenase BM524_13950 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BM524_13955 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) BM524_13960 ENOG41082RQ UPF0102 protein BM524_13970 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BM524_13975 ENOG4105W4M Transport-associated protein BM524_14005 ENOG4105CR4 methylisocitrate lyase BM524_14010 ENOG4105BZN citrate synthase BM524_14015 ENOG4108I0Z Aconitate hydratase BM524_14020 ENOG4105C7F AcnD-accessory protein PrpF BM524_14025 ENOG4105BZU Histidine kinase BM524_14045 ENOG4105BZU Histidine kinase BM524_14050 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BM524_14055 ENOG4105CBC glutamate synthase BM524_14060 ENOG4105BZ8 glutamate synthase BM524_14080 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BM524_14085 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BM524_14090 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BM524_14095 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BM524_14110 ENOG4105CJP fad dependent oxidoreductase BM524_14115 ENOG4105KCV RNA signal recognition particle 4.5S RNA BM524_14120 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BM524_14125 ENOG4108K5P (LipO)protein BM524_14130 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BM524_14135 ENOG4105EDR glucose galactose transporter BM524_14140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BM524_14160 ENOG4108U78 Glutathione S-transferase BM524_14165 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BM524_14175 ENOG4105CSR polyphosphate kinase 2 BM524_14180 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BM524_14185 ENOG4107QMS site-determining protein BM524_14190 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BM524_14195 ENOG4105C9Q fumarate hydratase class II BM524_14235 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BM524_14240 ENOG4105CHM Aminotransferase BM524_14250 ENOG4105CI3 gtp-binding protein typa BM524_14255 ENOG4105C5F glutamine synthetase BM524_14265 ENOG4105CUX Signal transduction histidine kinase BM524_14270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_14275 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_14280 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BM524_14285 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) BM524_14295 ENOG4105BZU Histidine kinase BM524_14315 ENOG4105BZU Histidine kinase BM524_14320 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BM524_14325 ENOG4105MYG DNA polymerase iii, chi subunit BM524_14330 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BM524_14335 ENOG4108M8S permease YjgP YjgQ family protein BM524_14340 ENOG4108K5H permease YjgP YjgQ family protein BM524_14355 ENOG4105K6V RNA polymerase BM524_14410 ENOG4105E2V Glycosyltransferase 36 BM524_14420 ENOG410620I Diguanylate cyclase BM524_14455 ENOG4105BZU Histidine kinase BM524_14475 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BM524_14480 ENOG4105EHG Permease protein BM524_14485 ENOG4107R4I Periplasmic binding protein BM524_14495 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BM524_14505 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BM524_14510 ENOG4105EMK carboxylate amino acid amine transporter BM524_14530 ENOG4107RF2 cellulose-binding family II protein BM524_14540 ENOG4105CY0 Metallo-Beta-Lactamase BM524_14550 ENOG4105DC7 peptidase M24 BM524_14555 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BM524_14560 ENOG4105BZU Histidine kinase BM524_14565 ENOG4108N2Y auxin Efflux BM524_14570 ENOG4105EY3 heparinase II III family protein BM524_14575 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 BM524_14580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BM524_14585 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BM524_14605 ENOG41088PD hydrolase BM524_14615 ENOG4105DZG Dehydrogenase BM524_14635 ENOG4105CJ1 ABC, transporter BM524_14645 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BM524_14650 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) BM524_14660 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d BM524_14665 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BM524_14695 ENOG4105BZU Histidine kinase BM524_14715 ENOG4105WH1 Two component transcriptional regulator luxr family BM524_14720 ENOG4105BZU Histidine kinase BM524_14725 ENOG4105JQN Transcriptional regulator BM524_14730 ENOG4105C26 Dehydrogenase BM524_14735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BM524_14740 ENOG4105C94 Transporter BM524_14745 ENOG4105CXG d-lactate dehydrogenase BM524_14750 ENOG41086KC Transcriptional regulator BM524_14755 ENOG4105P8Q Curli production assembly transport component CsgG BM524_14785 ENOG4105WH1 Two component transcriptional regulator luxr family BM524_14810 ENOG4105C1J atp-dependent rna helicase BM524_14830 ENOG4108UHU Aldolase BM524_14835 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BM524_14850 ENOG4105EGS Mechanosensitive ion channel BM524_14860 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BM524_14890 ENOG4105HF0 Membrane BM524_14895 ENOG4105CIH Imidazole acetol-phosphate transaminase BM524_14910 ENOG4105BZU Histidine kinase BM524_14920 ENOG4105CQ2 DNA polymerase BM524_14930 ENOG4105CEY Amp-dependent synthetase and ligase BM524_14970 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) BM524_14975 ENOG4105EJ2 Transcriptional regulator BM524_14985 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BM524_14995 ENOG4108RG0 uracil-dna glycosylase BM524_15000 ENOG4105BZU Histidine kinase BM524_15010 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BM524_15015 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BM524_15040 ENOG4105FM1 phage shock protein C BM524_15045 ENOG41087YS Phage shock protein A BM524_15055 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BM524_15120 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BM524_15185 ENOG4105EDQ levansucrase EC 2.4.1.10 BM524_15190 ENOG4108HKT sucrose-6-phosphate hydrolase BM524_15205 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BM524_15210 ENOG4105BZU Histidine kinase BM524_15215 ENOG4105C4W S-formylglutathione hydrolase BM524_15220 ENOG4106HNH Acyl-transferase BM524_15225 ENOG4106HNH Acyl-transferase BM524_15230 ENOG4105CUY Mechanosensitive ion channel BM524_15245 ENOG4108535 NAD dependent epimerase/dehydratase family BM524_15250 ENOG4105C8J )-transporter BM524_15265 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BM524_15280 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BM524_15290 ENOG4109015 Biopolymer transport protein exbD tolR BM524_15305 ENOG4105EJG cellulose synthase BM524_15310 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) BM524_15320 ENOG4107QZ7 Cellulose synthase catalytic subunit BM524_15335 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BM524_15340 ENOG4105K4T epimerase BM524_15355 ENOG4105KWG Pfam:DUF1696 BM524_15360 ENOG4105BZU Histidine kinase BM524_15370 ENOG4105EFZ amidohydrolase BM524_15380 ENOG4105C5X domain protein BM524_15390 ENOG4108WAV Transcriptional regulator BM524_15395 ENOG4105E7A Glutamine amidotransferase BM524_15405 ENOG4108Z12 YiaAB two helix domain-containing protein BM524_15440 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BM524_15445 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BM524_15455 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BM524_15470 ENOG4105CJ2 (LipO)protein BM524_15475 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BM524_15480 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BM524_15485 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BM524_15490 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BM524_15495 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BM524_15500 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BM524_15505 ENOG4105RKW reductase (By BM524_15510 ENOG4108V1T peptidylprolyl cis-trans isomerase BM524_15515 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BM524_15530 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BM524_15535 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BM524_15560 ENOG4105DBI uridine monophosphokinase BM524_15565 ENOG4105D9N nucleoside BM524_15585 ENOG4105BZU Histidine kinase BM524_15590 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BM524_15600 ENOG4107QN1 sodium solute BM524_15610 ENOG4105BZU Histidine kinase BM524_15620 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BM524_15630 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BM524_15645 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BM524_15660 ENOG4105CPC Aldo Keto reductase BM524_15685 ENOG4105D9P serine threonine protein kinase BM524_15735 ENOG4105CH6 catalase BM524_15745 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BM524_15770 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BM524_15775 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BM524_15780 ENOG4105D4A Cell wall formation (By similarity) BM524_15785 ENOG4107SDU Methyl-accepting chemotaxis BM524_15825 ENOG4108JJA ABC, transporter BM524_15830 ENOG41063Z6 transcriptional regulator, lysR family BM524_15865 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BM524_15880 ENOG4105D3Q Sugar transferase BM524_15900 ENOG4107RRD Dehydrogenase BM524_15930 ENOG4105EGZ biosynthesis protein BM524_15950 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BM524_15955 ENOG4105C1B dTDP-glucose 4-6-dehydratase BM524_15960 ENOG4108IJ1 Dehydrogenase BM524_15965 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BM524_15980 ENOG4105I03 Flagellin BM524_15990 ENOG4108ZT0 50S ribosomal protein l17 BM524_15995 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BM524_16000 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BM524_16005 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BM524_16010 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BM524_16015 ENOG41067V7 50S ribosomal protein L36 BM524_16020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BM524_16025 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BM524_16030 ENOG4105VPB 50S ribosomal protein L30 BM524_16035 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BM524_16040 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BM524_16045 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BM524_16050 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BM524_16055 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BM524_16060 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BM524_16065 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BM524_16070 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BM524_16075 ENOG4105BZU Histidine kinase BM524_16085 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BM524_16090 ENOG4105C2N RNA methyltransferase TrmH family group 3 BM524_16095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BM524_16130 ENOG4108UV7 flagellar protein motX BM524_16140 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BM524_16145 ENOG4107QK7 reductase BM524_16155 ENOG4107VAM peptidase, m28 BM524_16165 ENOG4105BZU Histidine kinase BM524_16175 ENOG4105C4M (Ubiquinol oxidase) subunit I BM524_16180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BM524_16185 ENOG4108XM1 transcriptional regulator AsnC family BM524_16195 ENOG4105VEQ Cold shock protein BM524_16200 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BM524_16220 ENOG4105DGW oligopeptidase A BM524_16225 ENOG4107YTP response regulator receiver protein BM524_16235 ENOG4105BZU Histidine kinase BM524_16240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_16245 ENOG4105DC8 reductase BM524_16250 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BM524_16255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BM524_16300 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BM524_16305 ENOG4108JJA ABC, transporter BM524_16310 ENOG4105WH1 Two component transcriptional regulator luxr family BM524_16335 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BM524_16340 ENOG4108HKT sucrose-6-phosphate hydrolase BM524_16355 ENOG4105C27 TonB-dependent Receptor Plug BM524_16360 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BM524_16365 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BM524_16370 ENOG4105VEQ Cold shock protein BM524_16375 ENOG41063M6 Cell Division Protein BM524_16380 ENOG4105C25 Primosomal protein n' BM524_16385 ENOG4105VFB Binds the 23S rRNA (By similarity) BM524_16395 ENOG4105C6K Malic enzyme BM524_16400 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BM524_16405 ENOG4105SYT Methylenetetrahydrofolate reductase BM524_16410 ENOG4107S2Z UPF0761 membrane protein BM524_16430 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BM524_16435 ENOG4105SUU thioesterase domain BM524_16440 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_16445 ENOG4105D58 Diguanylate phosphodiesterase BM524_16450 ENOG4105D58 Diguanylate phosphodiesterase BM524_16455 ENOG4105CRP Part of the ABC transporter FtsEX involved in BM524_16460 ENOG4105CAK Cell division ATP-binding protein ftsE BM524_16465 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BM524_16475 ENOG4106H78 methyltransferase BM524_16485 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BM524_16505 ENOG4105PW4 Sugar fermentation stimulation protein homolog BM524_16510 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BM524_16515 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BM524_16520 ENOG4105DJ0 Poly(A) Polymerase BM524_16525 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BM524_16530 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BM524_16535 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BM524_16540 ENOG4105DY8 decarboxylase BM524_16555 ENOG4105E3A (ABC) transporter BM524_16560 ENOG4105DA5 (ABC) transporter BM524_16565 ENOG4105E3W Two component transcriptional regulator (Winged helix family BM524_16570 ENOG4105EB3 Histidine kinase BM524_16575 ENOG4108ESX Receptor BM524_16580 ENOG4107E2E PKHD-type hydroxylase BM524_16605 ENOG4105D22 carbon starvation protein BM524_16625 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BM524_16630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BM524_16635 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BM524_16640 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BM524_16645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BM524_16650 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BM524_16655 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BM524_16660 ENOG4108VZM 50s ribosomal protein L10 BM524_16665 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BM524_16670 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BM524_16690 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BM524_16695 ENOG4105PM1 preprotein translocase subunit SecE BM524_16705 ENOG4105BZ1 (ABC) transporter BM524_16710 ENOG4105JSC dimethylmenaquinone methyltransferase BM524_16715 ENOG4105C9K Endothelin-converting enzyme 1 BM524_16725 ENOG4105C1J atp-dependent rna helicase BM524_16730 ENOG4105EKE dihydroorotase BM524_16735 ENOG4105QNF Outer membrane lipoprotein BM524_16740 ENOG4107RGM aldo keto reductase BM524_16745 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BM524_16755 ENOG4105DP8 Major facilitator superfamily MFS_1 BM524_16760 ENOG4107QW3 Sucrose phosphorylase BM524_16770 ENOG4105EUJ GTP cyclohydrolase i BM524_16775 ENOG410642E Short chain dehydrogenase BM524_16780 ENOG4105DWY Agmatine deiminase BM524_16795 ENOG4107QRT dEAD DEAH box helicase BM524_16805 ENOG4107T0X DNA ligase BM524_16810 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BM524_16815 ENOG4105D7K pfkb domain protein BM524_16830 ENOG4105CYM Glutathione S-transferase BM524_16845 ENOG4107IFA Lipase (EC 3.1.1.3) BM524_16850 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BM524_16875 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BM524_16880 ENOG4105CFC Transporter BM524_16885 ENOG4105EPW hflc protein BM524_16890 ENOG4107QJR hflk protein BM524_16895 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BM524_16900 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BM524_16905 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BM524_16910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BM524_16915 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BM524_16920 ENOG4105K8N protein family UPF0079, ATPase BM524_16925 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BM524_16930 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BM524_16940 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BM524_16950 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor BM524_16955 ENOG4105MYN Zinc uptake regulation protein BM524_16965 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BM524_16970 ENOG4105CDV Ompa motb domain protein BM524_16975 ENOG4105CDU Replicative dna helicase BM524_17000 ENOG4108RPX mosc domain containing protein BM524_17020 ENOG410804D Sensor Signal Transduction Histidine Kinase BM524_17045 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BM524_17050 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BM524_17055 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BM524_17060 ENOG4105BZU Histidine kinase BM524_17070 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BM524_17080 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BM524_17085 ENOG4105BZU Histidine kinase BM524_17090 ENOG4105C8Q Methyl-accepting chemotaxis BM524_17110 ENOG4106IBS oxygenase BM524_17135 ENOG4107RUZ Sss sodium solute transporter superfamily BM524_17140 ENOG4107ZSV Receptor BM524_17145 ENOG4105PGM cation diffusion facilitator family transporter BM524_17160 ENOG4105DFD Na H antiporter BM524_17180 ENOG41060NJ transcriptional regulator BM524_17185 ENOG4107QNK )-transporter BM524_17190 ENOG4108JJ8 (ABC) transporter BM524_17195 ENOG4108JJ9 ABC, transporter BM524_17205 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BM524_17210 ENOG4105C4M (Ubiquinol oxidase) subunit I BM524_17245 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BM524_17255 ENOG4105BZU Histidine kinase BM524_17265 ENOG4105Q26 Siderophore-interacting protein BM524_17270 ENOG4105VDW Csbd family BM524_17285 ENOG4105EMN RNA polymerase sigma factor BM524_17290 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BM524_17310 ENOG4108YZN class I peptide chain release factor BM524_17315 ENOG4107TTQ Alpha beta hydrolase fold BM524_17335 ENOG4105DS1 cytochrome b561 BM524_17345 ENOG4105CEP NADH dehydrogenase BM524_17360 ENOG4105CR8 Transcriptional regulator BM524_17365 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BM524_17370 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BM524_17380 ENOG4105BZU Histidine kinase BM524_17390 ENOG4105DEN Luciferase family BM524_17395 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BM524_17400 ENOG4105E98 transcriptional regulator DeoR family BM524_17405 ENOG4105D9R oxidoreductase BM524_17410 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BM524_17420 ENOG4108Q5Y Membrane BM524_17425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BM524_17430 ENOG4105D03 DNA-3-methyladenine glycosylase II BM524_17435 ENOG41066YJ Beta-lactamase BM524_17440 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BM524_17450 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BM524_17455 ENOG4105W8H transhydrogenase (subunit alpha BM524_17460 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BM524_17510 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BM524_17535 ENOG4108J20 pectate lyase BM524_17540 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BM524_17545 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BM524_17550 ENOG4105FS0 cytoplasmic membrane protein BM524_17555 ENOG4105VF7 tolerance protein BM524_17560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BM524_17565 ENOG4105DR5 peptidase BM524_17570 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BM524_17575 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BM524_17580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BM524_17625 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BM524_17635 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BM524_17640 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BM524_17645 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BM524_17650 ENOG4105DC1 bifunctional purine biosynthesis protein purh BM524_17660 ENOG4105C12 Phosphoribosylglycinamide synthetase BM524_17680 ENOG4105EYW Ion transport protein BM524_17685 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BM524_17695 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BM524_17700 ENOG4105E0F Histidine kinase BM524_17710 ENOG4105CJQ hydrolase, family 31 BM524_17715 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BM524_17720 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BM524_17725 ENOG4105VEJ Heat shock protein BM524_17730 ENOG4108XKW General secretion pathway protein C BM524_17740 ENOG4107QHF type ii secretion system protein e BM524_17745 ENOG4105D7Q type ii secretion system BM524_17750 ENOG4108VAU general secretion pathway protein G BM524_17755 ENOG4105VWV general secretion pathway protein h BM524_17800 ENOG4105C26 Dehydrogenase BM524_17810 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BM524_17815 ENOG4107RK2 ADP-ribose diphosphatase NudE BM524_17830 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) BM524_17835 ENOG4105DJ9 glucan biosynthesis protein BM524_17845 ENOG4105YP7 UPF0270 protein BM524_17850 ENOG4105DNZ Alpha Beta Hydrolase BM524_17860 ENOG4105C5H ABC transporter BM524_17875 ENOG41069P5 Protein slyX homolog BM524_17885 ENOG4108V1T peptidylprolyl cis-trans isomerase BM524_17895 ENOG4108RRZ Transcription elongation factor GreB BM524_17900 ENOG4105BZM domain protein BM524_17920 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BM524_17925 ENOG4105MJ2 Competence protein BM524_17935 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BM524_17960 ENOG4107R73 Mate efflux family protein BM524_17965 ENOG4107BJW polysaccharide deacetylase BM524_17975 ENOG4108ZX6 Electron transport protein SCO1 SenC BM524_17980 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BM524_17985 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BM524_18005 ENOG4107QS1 Cytochrome C Oxidase, Subunit III BM524_18010 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) BM524_18015 ENOG4105BZ9 Cytochrome C oxidase, subunit I BM524_18025 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BM524_18030 ENOG4105BZU Histidine kinase BM524_18035 ENOG4105E55 glycerol-3-phosphate acyltransferase BM524_18040 ENOG4105C7B Threonine dehydratase BM524_18045 ENOG4105C01 Dihydroxy-acid dehydratase BM524_18050 ENOG4105EN6 Membrane BM524_18055 ENOG4105C0P Mg chelatase subunit ChlI BM524_18060 ENOG4105EMY transcriptional regulator BM524_18065 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BM524_18070 ENOG4105C2C drug resistance transporter, Bcr CflA BM524_18075 ENOG4105V1F Fermentation respiration switch protein BM524_18080 ENOG4105CFU surface antigen BM524_18085 ENOG4105MA0 exported protein BM524_18110 ENOG4105C5I Dehydrogenase BM524_18120 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BM524_18165 ENOG4105CI2 imidazolone-5-propionate hydrolase BM524_18190 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BM524_18195 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BM524_18200 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BM524_18205 ENOG4105DSJ YicC domain protein BM524_18250 ENOG4105QV4 Tryptophan halogenase BM524_18270 ENOG4105CT4 transporter BM524_18275 ENOG41060NJ transcriptional regulator BM524_18285 ENOG4105CDV Ompa motb domain protein BM524_18290 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BM524_18305 ENOG4108K3A Glutathione S-transferase BM524_18315 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BM524_18320 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BM524_18325 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BM524_18330 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BM524_18335 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BM524_18340 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BM524_18345 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BM524_18350 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BM524_18360 ENOG4105FA0 parb-like partition protein BM524_18365 ENOG4107QJE Chromosome Partitioning Protein BM524_18370 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BM524_18375 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BM524_18390 ENOG4105QTB Flavodoxin BM524_18395 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BM524_18400 ENOG4108VPT UPF0234 protein BM524_18405 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BM524_18410 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BM524_18415 ENOG4105VG0 50S ribosomal protein l34 BM524_18440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BM524_18560 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_18625 ENOG4107QHF type ii secretion system protein e BM524_18655 ENOG4107QHF type ii secretion system protein e BM524_19160 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BM524_19250 ENOG4105EXC Acyl-transferase BM524_19370 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BM524_19660 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BM524_19665 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BM524_19740 ENOG4105CDV Ompa motb domain protein BM524_19765 ENOG4107QUV Domain protein BM524_19775 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BM524_19820 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BM524_19870 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BM524_19900 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_19920 ENOG4105C3J Cysteine desulfurase BM524_19925 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BM524_19950 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BM524_19985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BM524_19990 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BM524_19995 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BM524_20050 ENOG4105DZR Type I site-specific deoxyribonuclease BM524_20090 ENOG4107RRE RNA-directed DNA polymerase BM524_20100 ENOG4105C7H Helicase, RecD TraA family BM524_20125 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_20140 ENOG4105C0B DNA polymerase III (alpha subunit) BM524_20170 ENOG4105BZU Histidine kinase BM524_20190 ENOG4105D7V transposase BM524_20195 ENOG4105C4R Atp-dependent dna helicase BM524_20215 ENOG4107XMK single-stranded DNA-binding protein BM524_20245 ENOG4105K70 DNA-binding protein BM524_20450 ENOG4105ECI YeeC-like protein BM524_20455 ENOG4105F6A helicase BM524_20460 ENOG4105D85 methylase BM524_20470 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BM524_20515 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BM524_20555 ENOG4105C2M dna polymerase I BM524_20600 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BM524_20625 ENOG4105CKD glutathione-regulated potassium-efflux system protein BM524_20680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BM524_20720 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_20725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BM524_20740 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BM524_20745 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BM524_20795 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BM524_20920 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BM524_20995 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BM524_21000 ENOG4105D58 Diguanylate phosphodiesterase BM524_21005 ENOG4108IAB Phoh family BM524_21020 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BM524_21025 ENOG4108IJ1 Dehydrogenase BM524_21035 ENOG4105CMR udp-glucose 4-epimerase BM524_21095 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BM524_21100 ENOG4105BZU Histidine kinase BM524_21110 ENOG4105CAQ asparagine synthetase BM524_21120 ENOG4107QJE Chromosome Partitioning Protein BM524_21125 ENOG4105FA0 parb-like partition protein BM524_21140 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BM524_21145 ENOG4108QV3 biosynthesis protein BM524_21175 ENOG4105CAQ asparagine synthetase BM524_21185 ENOG4105PSV Polysaccharide Biosynthesis Protein BM524_21195 ENOG4107QUV Domain protein BM524_21220 ENOG4105CJB Exodeoxyribonuclease I BM524_21280 ENOG4105BZU Histidine kinase BM524_21305 ENOG4105C7H Helicase, RecD TraA family BM524_21340 ENOG4105C3F Signal peptidase i BM524_21380 ENOG4108Z33 Thiol disulfide Interchange Protein