locus-tag	class	description
BM524_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM524_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM524_00020	COG0187	DNA topoisomerase II activity
BM524_00050	COG2818	Glycosylase
BM524_00060	COG3078	GTPase activator activity
BM524_00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_00080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_00085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM524_00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM524_00095	COG0569	domain protein
BM524_00100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM524_00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM524_00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM524_00120	COG0758	DNA mediated transformation
BM524_00135	COG0009	L-threonylcarbamoyladenylate synthase
BM524_00140	COG0408	coproporphyrinogen oxidase activity
BM524_00145	COG3047	cAMP biosynthetic process
BM524_00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM524_00230	COG2234	aminopeptidase activity
BM524_00235	COG3562	capsule polysaccharide
BM524_00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM524_00270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_00300	COG3642	lipopolysaccharide core region biosynthetic process
BM524_00305	COG0859	PFAM glycosyl transferase family 9
BM524_00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_00350	COG3161	chorismate lyase activity
BM524_00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM524_00375	COG0210	DNA helicase
BM524_00395	COG4771	TonB-dependent receptor
BM524_00400	COG0583	DNA-binding transcription factor activity
BM524_00420	COG0667	Aldo Keto reductase
BM524_00445	COG2159	amidohydrolase
BM524_00455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM524_00490	COG1959	2 iron, 2 sulfur cluster binding
BM524_00495	COG0730	response to heat
BM524_00525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM524_00530	COG4988	ABC transporter
BM524_00540	COG1271	oxidase subunit
BM524_00545	COG0425	Belongs to the sulfur carrier protein TusA family
BM524_00545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_00555	COG0450	alkyl hydroperoxide reductase
BM524_00560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_00590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_00595	COG0842	Transport permease protein
BM524_00595	COG1129	ABC transporter
BM524_00600	COG0842	Transport permease protein
BM524_00610	COG4771	TonB-dependent receptor
BM524_00625	COG0583	DNA-binding transcription factor activity
BM524_00635	COG3106	COG3106 Predicted ATPase
BM524_00650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM524_00670	COG0352	thiamine-phosphate diphosphorylase activity
BM524_00680	COG3071	HemY protein
BM524_00685	COG2959	enzyme of heme biosynthesis
BM524_00695	COG0181	hydroxymethylbilane synthase activity
BM524_00700	COG3706	GGDEF domain
BM524_00710	COG0194	GDP metabolic process
BM524_00720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM524_00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM524_00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM524_00745	COG0678	peroxiredoxin activity
BM524_00760	COG1178	ABC-type Fe3 transport system permease component
BM524_00765	COG3842	ATPase activity
BM524_00770	COG0668	transmembrane transport
BM524_00775	COG2081	HI0933 family
BM524_00785	COG2200	EAL domain
BM524_00790	COG0583	DNA-binding transcription factor activity
BM524_00800	COG2076	Multidrug Resistance protein
BM524_00815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_00830	COG0427	acetyl-CoA hydrolase
BM524_00835	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM524_00850	COG0840	transmembrane signaling receptor activity
BM524_00860	COG3064	Membrane
BM524_00870	COG5002	protein histidine kinase activity
BM524_00870	COG5001	Diguanylate cyclase
BM524_00885	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_00890	COG2239	Acts as a magnesium transporter
BM524_00895	COG2962	Rard protein
BM524_00900	COG3706	GGDEF domain
BM524_00900	COG0745	RESPONSE REGULATOR receiver
BM524_00905	COG0210	DNA helicase
BM524_00915	COG1011	Hydrolase
BM524_00930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM524_00935	COG0019	diaminopimelate decarboxylase activity
BM524_00965	COG0163	prenyltransferase activity
BM524_00970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM524_00980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM524_01005	COG1077	Cell shape determining protein MreB Mrl
BM524_01020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM524_01025	COG2814	Major facilitator Superfamily
BM524_01030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_01060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM524_01075	COG0629	single-stranded DNA binding
BM524_01100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_01125	COG1349	DNA-binding transcription factor activity
BM524_01170	COG3267	Type II secretory pathway component ExeA
BM524_01170	COG3409	Peptidoglycan-binding domain 1 protein
BM524_01180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_01185	COG1459	type II secretion system
BM524_01230	COG1077	Cell shape determining protein MreB Mrl
BM524_01235	COG1792	Involved in formation and maintenance of cell shape
BM524_01240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM524_01250	COG1530	ribonuclease E activity
BM524_01260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_01265	COG0312	modulator of DNA gyrase
BM524_01270	COG3028	Belongs to the UPF0307 family
BM524_01275	COG0312	modulator of DNA gyrase
BM524_01290	COG0745	RESPONSE REGULATOR receiver
BM524_01295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_01295	COG4191	Histidine kinase
BM524_01300	COG0297	glycogen (starch) synthase activity
BM524_01310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM524_01315	COG0596	Alpha beta hydrolase
BM524_01355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BM524_01390	COG0745	RESPONSE REGULATOR receiver
BM524_01395	COG0643	Histidine kinase
BM524_01395	COG2198	Histidine kinase
BM524_01400	COG0835	chemotaxis
BM524_01415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM524_01430	COG0745	RESPONSE REGULATOR receiver
BM524_01440	COG0835	chemotaxis
BM524_01460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM524_01510	COG0546	phosphoglycolate phosphatase activity
BM524_01535	COG0673	inositol 2-dehydrogenase activity
BM524_01545	COG2211	Major facilitator Superfamily
BM524_01550	COG1082	Xylose isomerase domain protein TIM barrel
BM524_01570	COG1454	alcohol dehydrogenase
BM524_01645	COG0089	rRNA binding
BM524_01655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM524_01665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM524_01680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM524_01685	COG0438	transferase activity, transferring glycosyl groups
BM524_01695	COG1519	Transferase
BM524_01715	COG0840	transmembrane signaling receptor activity
BM524_01730	COG0788	formyltetrahydrofolate deformylase activity
BM524_01740	COG1643	Atp-dependent helicase
BM524_01745	COG2951	lytic endotransglycosylase activity
BM524_01750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM524_01760	COG2354	Protein conserved in bacteria
BM524_01770	COG4977	sequence-specific DNA binding
BM524_01785	COG0004	ammonium transporteR
BM524_01790	COG0405	Gamma-glutamyltransferase
BM524_01795	COG2837	iron assimilation
BM524_01810	COG0540	Belongs to the ATCase OTCase family
BM524_01835	COG0784	Response regulator, receiver
BM524_01835	COG2205	protein histidine kinase activity
BM524_01835	COG5002	protein histidine kinase activity
BM524_01850	COG3300	MHYT domain
BM524_01850	COG5001	Diguanylate cyclase
BM524_01860	COG1012	belongs to the aldehyde dehydrogenase family
BM524_01870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM524_01885	COG0180	Tryptophanyl-tRNA synthetase
BM524_01890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM524_01910	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM524_01920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM524_01955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM524_01960	COG0281	malic enzyme
BM524_01970	COG0625	glutathione transferase activity
BM524_01980	COG0753	catalase activity
BM524_02005	COG5001	Diguanylate cyclase
BM524_02005	COG3300	MHYT domain
BM524_02010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM524_02010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM524_02020	COG0137	argininosuccinate synthase activity
BM524_02040	COG1803	Methylglyoxal synthase
BM524_02050	COG0745	RESPONSE REGULATOR receiver
BM524_02055	COG2205	protein histidine kinase activity
BM524_02060	COG2267	carboxylic ester hydrolase activity
BM524_02065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM524_02075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM524_02085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM524_02090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_02095	COG4942	peptidase
BM524_02100	COG2861	carbohydrate metabolic process
BM524_02125	COG1162	GTPase activity
BM524_02130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM524_02155	COG0457	Tetratricopeptide repeat
BM524_02170	COG0028	Belongs to the TPP enzyme family
BM524_02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM524_02195	COG0805	protein transport
BM524_02205	COG0084	hydrolase, TatD family'
BM524_02210	COG3706	GGDEF domain
BM524_02210	COG2203	Gaf domain
BM524_02210	COG5001	Diguanylate cyclase
BM524_02210	COG4251	negative regulation of phosphorylation
BM524_02220	COG0248	Ppx GppA phosphatase
BM524_02225	COG0513	Belongs to the DEAD box helicase family
BM524_02230	COG3118	belongs to the thioredoxin family
BM524_02235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM524_02245	COG5002	protein histidine kinase activity
BM524_02245	COG0784	Response regulator, receiver
BM524_02250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BM524_02260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM524_02275	COG0783	Belongs to the Dps family
BM524_02280	COG2133	pyrroloquinoline quinone binding
BM524_02285	COG4946	Tricorn protease homolog
BM524_02285	COG1506	peptidase
BM524_02285	COG0823	Involved in the tonB-independent uptake of proteins
BM524_02295	COG3118	belongs to the thioredoxin family
BM524_02310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM524_02320	COG1012	belongs to the aldehyde dehydrogenase family
BM524_02345	COG1757	Na H antiporter
BM524_02360	COG3876	Protein conserved in bacteria
BM524_02365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM524_02375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BM524_02385	COG0346	lactoylglutathione lyase activity
BM524_02410	COG2824	Alkylphosphonate utilization operon protein PhnA
BM524_02415	COG0454	-acetyltransferase
BM524_02450	COG0183	Belongs to the thiolase family
BM524_02455	COG1024	Enoyl-CoA hydratase
BM524_02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_02465	COG0006	proline dipeptidase activity
BM524_02475	COG0142	geranyltranstransferase activity
BM524_02505	COG1388	LysM domain
BM524_02505	COG4942	peptidase
BM524_02510	COG1238	metal cluster binding
BM524_02520	COG0585	pseudouridine synthase activity
BM524_02525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM524_02535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM524_02545	COG0840	transmembrane signaling receptor activity
BM524_02580	COG0494	nUDIX hydrolase
BM524_02585	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM524_02590	COG0730	response to heat
BM524_02595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM524_02600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM524_02610	COG0745	RESPONSE REGULATOR receiver
BM524_02610	COG3706	GGDEF domain
BM524_02635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM524_02645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM524_02655	COG1648	precorrin-2 dehydrogenase activity
BM524_02655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM524_02660	COG0513	Belongs to the DEAD box helicase family
BM524_02675	COG1538	Outer membrane efflux protein
BM524_02680	COG0494	nUDIX hydrolase
BM524_02690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM524_02695	COG3150	esterase
BM524_02700	COG0187	DNA topoisomerase II activity
BM524_02710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_02735	COG1509	lysine 2,3-aminomutase activity
BM524_02745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM524_02760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM524_02765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM524_02780	COG0271	Belongs to the BolA IbaG family
BM524_02785	COG0671	phosphoesterase, PA-phosphatase related
BM524_02795	COG3707	response regulator
BM524_02810	COG0659	secondary active sulfate transmembrane transporter activity
BM524_02815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM524_02825	COG0243	molybdopterin cofactor binding
BM524_02830	COG1648	precorrin-2 dehydrogenase activity
BM524_02830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM524_02835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM524_02845	COG1116	anion transmembrane transporter activity
BM524_02845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM524_02855	COG1116	anion transmembrane transporter activity
BM524_02870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM524_02875	COG4206	TonB-dependent receptor
BM524_02880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM524_02885	COG0348	domain, Protein
BM524_02900	COG1960	acyl-CoA dehydrogenase activity
BM524_02905	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_02915	COG4948	Mandelate Racemase Muconate Lactonizing
BM524_02930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_02935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_02955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM524_02960	COG0358	DNA primase activity
BM524_02965	COG1610	YqeY-like protein
BM524_02985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM524_02990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM524_03005	COG0537	adenosine 5'-monophosphoramidase activity
BM524_03020	COG3135	benzoate transporter
BM524_03025	COG1396	sequence-specific DNA binding
BM524_03030	COG2974	May be involved in recombination
BM524_03035	COG4191	Histidine kinase
BM524_03035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_03040	COG0745	RESPONSE REGULATOR receiver
BM524_03045	COG5002	protein histidine kinase activity
BM524_03070	COG0811	peptide transport
BM524_03075	COG0811	peptide transport
BM524_03080	COG0848	biopolymer transport protein
BM524_03085	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM524_03095	COG3437	response regulator, receiver
BM524_03105	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_03115	COG2133	pyrroloquinoline quinone binding
BM524_03125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_03155	COG0527	aspartate kinase activity
BM524_03165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM524_03170	COG2967	ApaG domain
BM524_03180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM524_03185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_03190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM524_03195	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM524_03205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM524_03210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BM524_03225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM524_03240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM524_03245	COG3956	TIGRFAM MazG family protein
BM524_03270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM524_03275	COG0723	plastoquinol--plastocyanin reductase activity
BM524_03280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM524_03285	COG2857	Cytochrome c1
BM524_03290	COG0625	glutathione transferase activity
BM524_03295	COG2969	positive regulation of protein catabolic process
BM524_03310	COG0745	RESPONSE REGULATOR receiver
BM524_03315	COG2239	Acts as a magnesium transporter
BM524_03320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM524_03330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM524_03340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM524_03345	COG1137	ATPase activity
BM524_03350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM524_03360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM524_03375	COG1127	ABC transporter
BM524_03380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM524_03385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM524_03390	COG2854	intermembrane phospholipid transfer
BM524_03400	COG5007	Belongs to the BolA IbaG family
BM524_03410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM524_03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM524_03425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM524_03460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_03475	COG4771	TonB-dependent receptor
BM524_03480	COG0697	spore germination
BM524_03485	COG0784	Response regulator, receiver
BM524_03485	COG2205	protein histidine kinase activity
BM524_03510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM524_03520	COG0126	phosphoglycerate kinase activity
BM524_03525	COG3588	fructose-bisphosphate aldolase
BM524_03535	COG4946	Tricorn protease homolog
BM524_03535	COG0823	Involved in the tonB-independent uptake of proteins
BM524_03535	COG1506	peptidase
BM524_03540	COG0248	Ppx GppA phosphatase
BM524_03545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM524_03555	COG0573	inorganic phosphate transmembrane transporter activity
BM524_03565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM524_03575	COG0306	phosphate transporter
BM524_03585	COG0583	DNA-binding transcription factor activity
BM524_03595	COG1272	protein, Hemolysin III
BM524_03600	COG1846	Transcriptional regulator
BM524_03605	COG1764	response to oxidative stress
BM524_03620	COG1739	Uncharacterized protein family UPF0029
BM524_03630	COG0583	DNA-binding transcription factor activity
BM524_03635	COG4989	oxidoreductase activity
BM524_03650	COG0420	3'-5' exonuclease activity
BM524_03655	COG0419	ATPase involved in DNA repair
BM524_03665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BM524_03700	COG2986	histidine ammonia-lyase
BM524_03725	COG0488	(ABC) transporter
BM524_03750	COG0668	transmembrane transport
BM524_03765	COG0582	viral genome integration into host DNA
BM524_03770	COG4249	Peptidase C14 caspase catalytic subunit p20
BM524_03770	COG2319	Wd-40 repeat
BM524_03810	COG1518	maintenance of DNA repeat elements
BM524_03815	COG1203	CRISPR-associated helicase, Cas3
BM524_03865	COG1346	cytolysis
BM524_03895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM524_03905	COG0513	Belongs to the DEAD box helicase family
BM524_03915	COG3409	Peptidoglycan-binding domain 1 protein
BM524_03915	COG3267	Type II secretory pathway component ExeA
BM524_03930	COG0066	3-isopropylmalate dehydratase activity
BM524_03940	COG0473	3-isopropylmalate dehydrogenase activity
BM524_03945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM524_03970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM524_03985	COG4555	ABC transporter
BM524_03990	COG1668	transmembrane transport
BM524_04000	COG0745	RESPONSE REGULATOR receiver
BM524_04035	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_04040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_04045	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM524_04055	COG1138	Cytochrome C-type biogenesis protein
BM524_04060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM524_04075	COG2853	Lipoprotein
BM524_04080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM524_04090	COG3104	oligopeptide transport
BM524_04100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM524_04105	COG1596	polysaccharide export
BM524_04105	COG1555	photosystem II stabilization
BM524_04110	COG0473	3-isopropylmalate dehydrogenase activity
BM524_04125	COG1611	Belongs to the LOG family
BM524_04130	COG0745	RESPONSE REGULATOR receiver
BM524_04130	COG3706	GGDEF domain
BM524_04135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM524_04135	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM524_04190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM524_04195	COG0024	Methionine aminopeptidase
BM524_04200	COG0052	Belongs to the universal ribosomal protein uS2 family
BM524_04210	COG0528	UMP kinase activity
BM524_04220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM524_04225	COG0575	Belongs to the CDS family
BM524_04250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM524_04270	COG0587	DNA-directed DNA polymerase activity
BM524_04275	COG0825	malonyl-CoA metabolic process
BM524_04280	COG0037	tRNA processing
BM524_04300	COG0590	tRNA wobble adenosine to inosine editing
BM524_04310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM524_04310	COG0047	phosphoribosylformylglycinamidine synthase activity
BM524_04315	COG2840	Smr protein MutS2
BM524_04335	COG3047	cAMP biosynthetic process
BM524_04335	COG2885	chlorophyll binding
BM524_04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_04350	COG2197	response regulator
BM524_04390	COG0835	chemotaxis
BM524_04390	COG0784	Response regulator, receiver
BM524_04395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM524_04400	COG1815	bacterial-type flagellum-dependent cell motility
BM524_04405	COG1558	bacterial-type flagellum-dependent cell motility
BM524_04410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BM524_04415	COG1749	Flagellar hook protein flgE
BM524_04420	COG4787	bacterial-type flagellum-dependent cell motility
BM524_04425	COG4786	Flagellar basal body rod
BM524_04440	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM524_04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM524_04445	COG1256	bacterial-type flagellum assembly
BM524_04470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_04475	COG1334	flagellar protein FlaG
BM524_04480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM524_04530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM524_04535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_04535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM524_04545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_04555	COG1442	glycosyl transferase family 8
BM524_04565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM524_04570	COG1086	Polysaccharide biosynthesis protein
BM524_04585	COG3475	LICD family
BM524_04590	COG2089	acid synthase
BM524_04600	COG1083	cytidylyl-transferase
BM524_04610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM524_04620	COG2204	response regulator
BM524_04625	COG3852	Histidine kinase
BM524_04630	COG2204	response regulator
BM524_04635	COG1677	Flagellar hook-basal body complex protein FliE
BM524_04640	COG1766	The M ring may be actively involved in energy transduction
BM524_04645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM524_04695	COG1987	bacterial-type flagellum assembly
BM524_04710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM524_04720	COG0455	bacterial-type flagellum organization
BM524_04735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM524_04740	COG2198	Histidine kinase
BM524_04740	COG0643	Histidine kinase
BM524_04750	COG1192	Involved in chromosome partitioning
BM524_04760	COG0835	chemotaxis
BM524_04775	COG1410	methionine synthase
BM524_04775	COG0646	methionine synthase
BM524_04780	COG1410	methionine synthase
BM524_04780	COG0646	methionine synthase
BM524_04790	COG3123	guanosine phosphorylase activity
BM524_04800	COG0583	DNA-binding transcription factor activity
BM524_04805	COG0583	DNA-binding transcription factor activity
BM524_04815	COG0659	secondary active sulfate transmembrane transporter activity
BM524_04830	COG3590	peptidase
BM524_04840	COG2137	regulation of response to DNA damage stimulus
BM524_04845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM524_04875	COG5016	pyruvate
BM524_04875	COG0511	ligase activity, forming carbon-carbon bonds
BM524_04880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BM524_04885	COG4172	Belongs to the ABC transporter superfamily
BM524_04895	COG4171	peptide transport system, permease
BM524_04900	COG4168	peptide transport system, permease
BM524_04905	COG0747	negative chemotaxis
BM524_04910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM524_04915	COG1842	Phage shock protein A
BM524_04945	COG0625	glutathione transferase activity
BM524_04950	COG1522	sequence-specific DNA binding
BM524_05015	COG0811	peptide transport
BM524_05020	COG0811	peptide transport
BM524_05025	COG0848	biopolymer transport protein
BM524_05040	COG1444	tRNA N-acetyltransferase activity
BM524_05080	COG0456	acetyltransferase
BM524_05095	COG0583	DNA-binding transcription factor activity
BM524_05100	COG2814	Major facilitator Superfamily
BM524_05110	COG0656	L-ascorbic acid biosynthetic process
BM524_05130	COG1846	Transcriptional regulator
BM524_05160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM524_05190	COG0543	2 iron, 2 sulfur cluster binding
BM524_05190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM524_05205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM524_05210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM524_05215	COG0564	pseudouridine synthase activity
BM524_05225	COG0612	Peptidase, M16
BM524_05230	COG2918	glutathione biosynthetic process
BM524_05250	COG2840	Smr protein MutS2
BM524_05255	COG2890	protein-(glutamine-N5) methyltransferase activity
BM524_05270	COG2719	SpoVR family
BM524_05275	COG2718	Belongs to the UPF0229 family
BM524_05280	COG2766	serine protein kinase
BM524_05290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM524_05295	COG4771	TonB-dependent receptor
BM524_05320	COG0450	alkyl hydroperoxide reductase
BM524_05325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM524_05330	COG2885	chlorophyll binding
BM524_05335	COG0584	glycerophosphoryl diester phosphodiesterase
BM524_05340	COG0346	lactoylglutathione lyase activity
BM524_05345	COG1278	Cold shock
BM524_05365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM524_05370	COG4660	Part of a membrane complex involved in electron transport
BM524_05375	COG4659	FMN binding
BM524_05380	COG4658	electron transport chain
BM524_05385	COG4656	Part of a membrane complex involved in electron transport
BM524_05390	COG2878	Part of a membrane complex involved in electron transport
BM524_05410	COG0534	Mate efflux family protein
BM524_05415	COG0556	nucleotide-excision repair
BM524_05430	COG0602	queuosine metabolic process
BM524_05440	COG0367	asparagine synthase
BM524_05465	COG0471	metal ion transport
BM524_05465	COG3273	potassium ion transport
BM524_05480	COG0529	Catalyzes the synthesis of activated sulfate
BM524_05485	COG0175	sulfate reduction
BM524_05490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_05520	COG2304	oxidoreductase activity
BM524_05540	COG0714	Associated with various cellular activities
BM524_05550	COG1024	Enoyl-CoA hydratase
BM524_05550	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_05565	COG1025	Belongs to the peptidase M16 family
BM524_05570	COG2062	phosphohistidine phosphatase, SixA
BM524_05580	COG4536	flavin adenine dinucleotide binding
BM524_05585	COG4137	Cytochrome C assembly protein
BM524_05590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM524_05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_05640	COG1132	(ABC) transporter
BM524_05655	COG0228	four-way junction DNA binding
BM524_05660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM524_05665	COG0336	Belongs to the RNA methyltransferase TrmD family
BM524_05670	COG0335	large ribosomal subunit rRNA binding
BM524_05675	COG2860	membrane
BM524_05685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM524_05690	COG0287	Prephenate dehydrogenase
BM524_05690	COG1605	Chorismate mutase
BM524_05695	COG0077	Prephenate dehydratase
BM524_05695	COG1605	Chorismate mutase
BM524_05705	COG0023	Translation Initiation Factor
BM524_05735	COG2205	protein histidine kinase activity
BM524_05745	COG2204	response regulator
BM524_05750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_05765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM524_05770	COG0494	nUDIX hydrolase
BM524_05775	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM524_05785	COG2255	four-way junction helicase activity
BM524_05790	COG0824	Thioesterase
BM524_05795	COG0811	peptide transport
BM524_05810	COG0823	Involved in the tonB-independent uptake of proteins
BM524_05815	COG2885	chlorophyll binding
BM524_05820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM524_05840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM524_05855	COG4667	esterase of the alpha-beta hydrolase superfamily
BM524_05860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM524_05870	COG0784	Response regulator, receiver
BM524_05870	COG2205	protein histidine kinase activity
BM524_05885	COG0300	oxidoreductase activity
BM524_05890	COG3038	cytochrome b561
BM524_05920	COG0583	DNA-binding transcription factor activity
BM524_05925	COG1064	alcohol dehydrogenase
BM524_05930	COG1451	nucleotide metabolic process
BM524_05935	COG0517	IMP dehydrogenase activity
BM524_05940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_05950	COG1309	transcriptional regulator
BM524_05955	COG4774	siderophore transport
BM524_05975	COG3706	GGDEF domain
BM524_05985	COG3008	intermembrane lipid transfer
BM524_05985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM524_05990	COG2995	paraquat-inducible protein a
BM524_06010	COG2207	Transcriptional regulator
BM524_06015	COG0017	Asparaginyl-tRNA synthetase
BM524_06030	COG0189	ligase activity
BM524_06060	COG0156	8-amino-7-oxononanoate synthase activity
BM524_06065	COG2226	methyltransferase
BM524_06075	COG3340	Belongs to the peptidase S51 family
BM524_06080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM524_06085	COG4139	cobalamin transport
BM524_06090	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BM524_06095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM524_06110	COG5265	(ABC) transporter
BM524_06115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM524_06125	COG0745	RESPONSE REGULATOR receiver
BM524_06145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM524_06180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_06195	COG2755	lipolytic protein G-D-S-L family
BM524_06200	COG4181	ATPase activity
BM524_06205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM524_06210	COG1090	epimerase
BM524_06215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM524_06220	COG0628	permease
BM524_06230	COG0745	RESPONSE REGULATOR receiver
BM524_06245	COG2350	Protein conserved in bacteria
BM524_06250	COG0159	tryptophan synthase activity
BM524_06260	COG0135	phosphoribosylanthranilate isomerase activity
BM524_06260	COG0134	indole-3-glycerol-phosphate synthase activity
BM524_06265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM524_06275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM524_06280	COG0613	PHP domain protein
BM524_06285	COG0009	L-threonylcarbamoyladenylate synthase
BM524_06290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BM524_06295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM524_06305	COG0656	L-ascorbic acid biosynthetic process
BM524_06310	COG0110	maltose O-acetyltransferase activity
BM524_06320	COG2733	membrane
BM524_06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_06345	COG0500	methyltransferase
BM524_06350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_06355	COG0497	DNA recombination
BM524_06360	COG0783	Belongs to the Dps family
BM524_06370	COG1454	alcohol dehydrogenase
BM524_06375	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_06385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM524_06390	COG2610	gluconate transmembrane transporter activity
BM524_06410	COG2205	protein histidine kinase activity
BM524_06410	COG2198	Histidine kinase
BM524_06410	COG0784	Response regulator, receiver
BM524_06430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM524_06440	COG0484	heat shock protein binding
BM524_06445	COG3909	cytochrome
BM524_06465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM524_06470	COG0505	Belongs to the CarA family
BM524_06475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM524_06480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM524_06500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM524_06505	COG0857	belongs to the CobB CobQ family
BM524_06505	COG0280	phosphate acetyltransferase
BM524_06510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM524_06515	COG4535	Mg2 and Co2 transporter CorC
BM524_06525	COG1702	phosphate starvation-inducible protein PhoH
BM524_06535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_06565	COG1607	acyl-coa hydrolase
BM524_06570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM524_06580	COG1115	amino acid carrier protein
BM524_06625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM524_06630	COG0012	GTP binding
BM524_06645	COG1064	alcohol dehydrogenase
BM524_06660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM524_06670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM524_06675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM524_06680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM524_06690	COG2890	protein-(glutamine-N5) methyltransferase activity
BM524_06695	COG3437	response regulator, receiver
BM524_06695	COG0784	Response regulator, receiver
BM524_06700	COG3094	Invasion gene expression up-regulator, SirB
BM524_06715	COG0583	DNA-binding transcription factor activity
BM524_06725	COG2363	Small membrane protein
BM524_06740	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM524_06745	COG0515	serine threonine protein kinase
BM524_06750	COG2116	formate transmembrane transporter activity
BM524_06765	COG0714	Associated with various cellular activities
BM524_06770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM524_06775	COG0033	Phosphoglucomutase
BM524_06780	COG0058	SHG alpha-glucan phosphorylase activity
BM524_06790	COG2988	succinylglutamate desuccinylase activity
BM524_06825	COG1393	Belongs to the ArsC family
BM524_06850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM524_06880	COG1621	beta-fructofuranosidase activity
BM524_06930	COG2080	2 iron, 2 sulfur cluster binding
BM524_06940	COG0281	malic enzyme
BM524_06945	COG5001	Diguanylate cyclase
BM524_06945	COG3300	MHYT domain
BM524_06970	COG2249	NAD(P)H dehydrogenase (quinone) activity
BM524_06990	COG1733	regulation of RNA biosynthetic process
BM524_06995	COG3447	MASE1 domain protein
BM524_06995	COG5001	Diguanylate cyclase
BM524_06995	COG5002	protein histidine kinase activity
BM524_07005	COG0402	S-adenosylhomocysteine deaminase activity
BM524_07010	COG2351	hydroxyisourate hydrolase activity
BM524_07025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM524_07040	COG1309	transcriptional regulator
BM524_07055	COG2252	PERMEase
BM524_07060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM524_07075	COG5001	Diguanylate cyclase
BM524_07075	COG2203	Gaf domain
BM524_07075	COG4251	negative regulation of phosphorylation
BM524_07075	COG3706	GGDEF domain
BM524_07080	COG2205	protein histidine kinase activity
BM524_07080	COG0784	Response regulator, receiver
BM524_07095	COG2233	PERMEase
BM524_07110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM524_07115	COG0730	response to heat
BM524_07155	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_07170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM524_07185	COG0662	Cupin 2, conserved barrel domain protein
BM524_07185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BM524_07190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM524_07200	COG1596	polysaccharide export
BM524_07205	COG0489	protein tyrosine kinase activity
BM524_07210	COG4464	protein tyrosine phosphatase activity
BM524_07235	COG3300	MHYT domain
BM524_07235	COG5001	Diguanylate cyclase
BM524_07260	COG0463	Glycosyl transferase, family 2
BM524_07280	COG1215	transferase activity, transferring glycosyl groups
BM524_07285	COG0438	transferase activity, transferring glycosyl groups
BM524_07295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BM524_07315	COG0072	phenylalanine-tRNA ligase activity
BM524_07315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_07340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BM524_07350	COG1472	Belongs to the glycosyl hydrolase 3 family
BM524_07355	COG2096	Adenosyltransferase
BM524_07365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM524_07375	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM524_07400	COG0708	Exodeoxyribonuclease III
BM524_07435	COG2814	Major facilitator Superfamily
BM524_07475	COG1024	Enoyl-CoA hydratase
BM524_07480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM524_07485	COG1960	acyl-CoA dehydrogenase activity
BM524_07490	COG0789	Transcriptional regulator
BM524_07495	COG0183	Belongs to the thiolase family
BM524_07510	COG3706	GGDEF domain
BM524_07520	COG2925	Exonuclease
BM524_07570	COG1643	Atp-dependent helicase
BM524_07590	COG3321	synthase
BM524_07590	COG0604	alcohol dehydrogenase
BM524_07595	COG0328	RNA-DNA hybrid ribonuclease activity
BM524_07600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM524_07630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM524_07640	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM524_07655	COG3724	N-succinylarginine dihydrolase activity
BM524_07665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM524_07680	COG0746	molybdenum cofactor guanylyltransferase activity
BM524_07685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BM524_07690	COG0243	molybdopterin cofactor binding
BM524_07695	COG2153	protein acetylation
BM524_07710	COG1530	ribonuclease E activity
BM524_07730	COG1399	metal-binding, possibly nucleic acid-binding protein
BM524_07740	COG0416	fatty acid biosynthetic process
BM524_07745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM524_07750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM524_07760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM524_07765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM524_07775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM524_07790	COG0084	hydrolase, TatD family'
BM524_07800	COG0702	epimerase
BM524_07805	COG0745	RESPONSE REGULATOR receiver
BM524_07805	COG3706	GGDEF domain
BM524_07825	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_07830	COG0596	Alpha beta hydrolase
BM524_07840	COG0183	Belongs to the thiolase family
BM524_07845	COG1960	acyl-CoA dehydrogenase activity
BM524_07865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_07875	COG0246	Mannitol dehydrogenase
BM524_07900	COG0668	transmembrane transport
BM524_07905	COG4771	TonB-dependent receptor
BM524_07930	COG2205	protein histidine kinase activity
BM524_07930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_07935	COG3437	response regulator, receiver
BM524_07945	COG0195	Participates in both transcription termination and antitermination
BM524_07960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM524_07975	COG3300	MHYT domain
BM524_07975	COG5001	Diguanylate cyclase
BM524_07980	COG1187	pseudouridine synthase activity
BM524_07990	COG3153	acetyltransferase
BM524_07990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_08020	COG0450	alkyl hydroperoxide reductase
BM524_08065	COG1032	radical SAM domain protein
BM524_08080	COG4771	TonB-dependent receptor
BM524_08085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_08095	COG4134	Bacterial extracellular solute-binding protein
BM524_08105	COG4136	ATPase activity
BM524_08110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM524_08130	COG3706	GGDEF domain
BM524_08130	COG4251	negative regulation of phosphorylation
BM524_08130	COG5001	Diguanylate cyclase
BM524_08130	COG2203	Gaf domain
BM524_08150	COG0583	DNA-binding transcription factor activity
BM524_08170	COG1131	(ABC) transporter
BM524_08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_08190	COG0385	Bile acid
BM524_08215	COG3311	Transcriptional regulator
BM524_08245	COG0582	viral genome integration into host DNA
BM524_08255	COG1902	pentaerythritol trinitrate reductase activity
BM524_08265	COG2867	negative regulation of translational initiation
BM524_08270	COG2914	Belongs to the UPF0125 (RnfH) family
BM524_08280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_08290	COG0457	Tetratricopeptide repeat
BM524_08305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM524_08305	COG0574	Belongs to the PEP-utilizing enzyme family
BM524_08340	COG2850	peptidyl-arginine hydroxylation
BM524_08355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM524_08360	COG2915	High frequency lysogenization protein hflD homolog
BM524_08365	COG0482	sulfurtransferase activity
BM524_08370	COG1187	pseudouridine synthase activity
BM524_08380	COG1278	Cold shock
BM524_08385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM524_08390	COG0542	response to heat
BM524_08395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM524_08400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM524_08405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM524_08410	COG0492	ferredoxin-NADP+ reductase activity
BM524_08415	COG3092	negative regulation of chromosome organization
BM524_08420	COG3091	SprT-like family
BM524_08425	COG0616	signal peptide processing
BM524_08440	COG0778	Nitroreductase
BM524_08450	COG0252	asparaginase activity
BM524_08455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM524_08460	COG0321	lipoyl(octanoyl) transferase activity
BM524_08465	COG2921	Belongs to the UPF0250 family
BM524_08470	COG1686	Belongs to the peptidase S11 family
BM524_08475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM524_08480	COG0772	Belongs to the SEDS family
BM524_08485	COG0768	penicillin binding
BM524_08490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM524_08495	COG0799	negative regulation of ribosome biogenesis
BM524_08505	COG1466	dna polymerase III delta subunit
BM524_08510	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BM524_08515	COG0495	leucyl-tRNA aminoacylation
BM524_08525	COG1067	ATP-dependent peptidase activity
BM524_08530	COG0596	Alpha beta hydrolase
BM524_08535	COG3706	GGDEF domain
BM524_08545	COG1534	Rna-binding protein
BM524_08550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM524_08555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM524_08560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM524_08565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM524_08570	COG0149	triose-phosphate isomerase activity
BM524_08575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM524_08605	COG1597	lipid kinase activity
BM524_08605	COG1803	Methylglyoxal synthase
BM524_08615	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_08620	COG0561	phosphatase activity
BM524_08635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_08660	COG1185	polyribonucleotide nucleotidyltransferase activity
BM524_08820	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BM524_08825	COG1196	nuclear chromosome segregation
BM524_08835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM524_08850	COG1132	(ABC) transporter
BM524_08855	COG1663	tetraacyldisaccharide 4'-kinase activity
BM524_08895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM524_08900	COG0435	Glutathione S-transferase
BM524_08905	COG1741	Belongs to the pirin family
BM524_08910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM524_08920	COG0372	Belongs to the citrate synthase family
BM524_08925	COG2009	succinate dehydrogenase
BM524_08930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM524_08935	COG1053	succinate dehydrogenase
BM524_08940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM524_08945	COG0567	Dehydrogenase, E1 component
BM524_08950	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_08990	COG4667	esterase of the alpha-beta hydrolase superfamily
BM524_09010	COG0366	Alpha amylase catalytic
BM524_09035	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_09040	COG2267	carboxylic ester hydrolase activity
BM524_09050	COG0616	signal peptide processing
BM524_09070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM524_09075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM524_09080	COG0386	Belongs to the glutathione peroxidase family
BM524_09085	COG2084	Dehydrogenase
BM524_09095	COG1960	acyl-CoA dehydrogenase activity
BM524_09100	COG1024	Enoyl-CoA hydratase
BM524_09105	COG2226	methyltransferase
BM524_09110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM524_09115	COG3083	sulfuric ester hydrolase activity
BM524_09120	COG3082	Protein of unknown function (DUF1414)
BM524_09125	COG3081	Nucleoid-associated protein
BM524_09155	COG3275	phosphorelay sensor kinase activity
BM524_09160	COG3279	Response regulator of the LytR AlgR family
BM524_09165	COG0205	6-phosphofructokinase activity
BM524_09175	COG0789	Transcriptional regulator
BM524_09225	COG0745	RESPONSE REGULATOR receiver
BM524_09245	COG0513	Belongs to the DEAD box helicase family
BM524_09255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM524_09260	COG0583	DNA-binding transcription factor activity
BM524_09280	COG1760	l-serine dehydratase
BM524_09305	COG1322	Protein conserved in bacteria
BM524_09310	COG1404	Belongs to the peptidase S8 family
BM524_09315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM524_09320	COG0022	dehydrogenase e1 component
BM524_09330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM524_09335	COG0515	serine threonine protein kinase
BM524_09340	COG1946	Acyl-CoA thioesterase
BM524_09350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM524_09360	COG1956	GAF domain-containing protein
BM524_09375	COG0793	Belongs to the peptidase S41A family
BM524_09380	COG0733	neurotransmitter:sodium symporter activity
BM524_09390	COG0308	aminopeptidase N
BM524_09420	COG2902	Dehydrogenase
BM524_09425	COG0167	dihydroorotate dehydrogenase activity
BM524_09450	COG3130	regulation of translation
BM524_09455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM524_09465	COG0415	Belongs to the DNA photolyase family
BM524_09470	COG0415	Belongs to the DNA photolyase family
BM524_09475	COG0415	Belongs to the DNA photolyase family
BM524_09480	COG3046	protein related to deoxyribodipyrimidine photolyase
BM524_09495	COG4264	IucA IucC family
BM524_09500	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_09505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM524_09510	COG1082	Xylose isomerase domain protein TIM barrel
BM524_09540	COG4974	Belongs to the 'phage' integrase family
BM524_09550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM524_09555	COG0589	response to stress
BM524_09565	COG0069	glutamate synthase activity
BM524_09580	COG2193	ferroxidase activity
BM524_09590	COG3278	Belongs to the heme-copper respiratory oxidase family
BM524_09605	COG2010	Cytochrome c
BM524_09630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM524_09635	COG0589	response to stress
BM524_09640	COG0037	tRNA processing
BM524_09645	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM524_09665	COG1280	lysine exporter protein (LysE YggA)
BM524_09670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BM524_09675	COG2897	thiosulfate sulfurtransferase activity
BM524_09680	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM524_09710	COG0322	excinuclease ABC activity
BM524_09715	COG2197	response regulator
BM524_09720	COG0436	Aminotransferase
BM524_09725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM524_09740	COG0583	DNA-binding transcription factor activity
BM524_09745	COG2259	Doxx family
BM524_09755	COG0670	Belongs to the BI1 family
BM524_09760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM524_09775	COG2920	part of a sulfur-relay system
BM524_09805	COG4206	TonB-dependent receptor
BM524_09805	COG4206	TonB-dependent receptor
BM524_09820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM524_09830	COG0531	amino acid
BM524_09830	COG1674	ftsk spoiiie
BM524_09840	COG0686	Belongs to the AlaDH PNT family
BM524_09845	COG0284	orotidine-5'-phosphate decarboxylase activity
BM524_09850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM524_09865	COG0776	regulation of translation
BM524_09870	COG0539	negative regulation of cytoplasmic translation
BM524_09875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM524_09880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM524_09885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM524_09895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM524_09900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_09905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_09910	COG0633	Ferredoxin
BM524_09945	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM524_09950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM524_09960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM524_09970	COG4783	chaperone-mediated protein folding
BM524_09980	COG1393	Belongs to the ArsC family
BM524_09995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM524_10010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM524_10020	COG1960	acyl-CoA dehydrogenase activity
BM524_10045	COG0572	uridine kinase
BM524_10050	COG3769	mannosylglycerate metabolic process
BM524_10055	COG1215	transferase activity, transferring glycosyl groups
BM524_10060	COG0366	Alpha amylase catalytic
BM524_10070	COG0303	'Molybdopterin
BM524_10075	COG0534	Mate efflux family protein
BM524_10090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM524_10095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM524_10155	COG0405	Gamma-glutamyltransferase
BM524_10160	COG1024	Enoyl-CoA hydratase
BM524_10205	COG1448	Aminotransferase
BM524_10220	COG1671	Belongs to the UPF0178 family
BM524_10225	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_10230	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_10235	COG1960	acyl-CoA dehydrogenase activity
BM524_10240	COG0662	Cupin 2, conserved barrel domain protein
BM524_10240	COG2207	Transcriptional regulator
BM524_10245	COG4771	TonB-dependent receptor
BM524_10255	COG1505	serine-type exopeptidase activity
BM524_10265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_10295	COG0596	Alpha beta hydrolase
BM524_10305	COG0716	FMN binding
BM524_10315	COG0735	belongs to the Fur family
BM524_10325	COG1984	allophanate hydrolase subunit 2
BM524_10330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BM524_10335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM524_10340	COG2996	Protein conserved in bacteria
BM524_10345	COG1765	OsmC-like protein
BM524_10350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_10360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_10375	COG0436	Aminotransferase
BM524_10380	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM524_10385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM524_10410	COG3012	SEC-C Motif Domain Protein
BM524_10415	COG3447	MASE1 domain protein
BM524_10415	COG5002	protein histidine kinase activity
BM524_10415	COG5001	Diguanylate cyclase
BM524_10420	COG0366	Alpha amylase catalytic
BM524_10430	COG0604	alcohol dehydrogenase
BM524_10440	COG1960	acyl-CoA dehydrogenase activity
BM524_10450	COG4771	TonB-dependent receptor
BM524_10470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM524_10475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM524_10495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM524_10500	COG0315	cyclic pyranopterin monophosphate synthase activity
BM524_10505	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM524_10510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM524_10520	COG2161	toxin-antitoxin pair type II binding
BM524_10525	COG4115	mRNA cleavage
BM524_10540	COG0436	Aminotransferase
BM524_10545	COG3268	Saccharopine dehydrogenase
BM524_10550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM524_10565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BM524_10570	COG4206	TonB-dependent receptor
BM524_10580	COG5006	permease, DMT superfamily
BM524_10605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_10610	COG1074	ATP-dependent DNA helicase activity
BM524_10615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM524_10625	COG1022	Amp-dependent synthetase and ligase
BM524_10630	COG5001	Diguanylate cyclase
BM524_10650	COG0583	DNA-binding transcription factor activity
BM524_10665	COG0640	Transcriptional regulator
BM524_10685	COG2204	response regulator
BM524_10695	COG4251	negative regulation of phosphorylation
BM524_10700	COG0784	Response regulator, receiver
BM524_10705	COG2205	protein histidine kinase activity
BM524_10705	COG0784	Response regulator, receiver
BM524_10730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM524_10755	COG3139	Protein of unknown function (DUF1315)
BM524_10770	COG1115	amino acid carrier protein
BM524_10775	COG2866	Carboxypeptidase
BM524_10795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM524_10805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM524_10810	COG1640	4-alpha-glucanotransferase
BM524_10815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM524_10820	COG0676	glucose-6-phosphate 1-epimerase activity
BM524_10825	COG0800	Aldolase
BM524_10835	COG0129	dihydroxy-acid dehydratase activity
BM524_10845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM524_10850	COG1737	Transcriptional regulator
BM524_10855	COG0469	pyruvate kinase activity
BM524_10860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_10875	COG2823	Periplasmic or secreted lipoprotein
BM524_10905	COG3665	Urea carboxylase-associated protein
BM524_10925	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_10940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BM524_10955	COG2721	sulfolactate sulfo-lyase activity
BM524_10960	COG1904	glucuronate isomerase
BM524_10965	COG0246	Mannitol dehydrogenase
BM524_10970	COG0800	Aldolase
BM524_10975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_10980	COG2755	lipolytic protein G-D-S-L family
BM524_10990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BM524_11015	COG2356	endonuclease I
BM524_11020	COG0840	transmembrane signaling receptor activity
BM524_11035	COG0583	DNA-binding transcription factor activity
BM524_11040	COG1979	alcohol dehydrogenase
BM524_11045	COG5001	Diguanylate cyclase
BM524_11055	COG3437	response regulator, receiver
BM524_11055	COG0784	Response regulator, receiver
BM524_11060	COG4191	Histidine kinase
BM524_11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_11075	COG0471	metal ion transport
BM524_11085	COG0489	protein tyrosine kinase activity
BM524_11090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_11090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM524_11095	COG0668	transmembrane transport
BM524_11100	COG2226	methyltransferase
BM524_11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_11110	COG1388	LysM domain
BM524_11110	COG0741	lytic transglycosylase activity
BM524_11120	COG0215	cysteine-tRNA ligase activity
BM524_11125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM524_11130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM524_11140	COG2268	Band 7 protein
BM524_11155	COG1733	regulation of RNA biosynthetic process
BM524_11160	COG0604	alcohol dehydrogenase
BM524_11165	COG0753	catalase activity
BM524_11170	COG0604	alcohol dehydrogenase
BM524_11175	COG0583	DNA-binding transcription factor activity
BM524_11200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM524_11205	COG1286	toxin biosynthetic process
BM524_11210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM524_11215	COG0285	dihydrofolate synthase activity
BM524_11235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM524_11240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM524_11260	COG3609	addiction module antidote protein, CC2985 family
BM524_11270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM524_11285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM524_11285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM524_11315	COG0604	alcohol dehydrogenase
BM524_11340	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_11345	COG1119	ATPase activity
BM524_11350	COG2031	fatty acid transporter
BM524_11355	COG0784	Response regulator, receiver
BM524_11355	COG2205	protein histidine kinase activity
BM524_11355	COG5002	protein histidine kinase activity
BM524_11365	COG0612	Peptidase, M16
BM524_11380	COG3101	peptidyl-lysine hydroxylation
BM524_11405	COG1902	pentaerythritol trinitrate reductase activity
BM524_11405	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM524_11430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM524_11440	COG4399	Belongs to the UPF0754 family
BM524_11465	COG1770	oligopeptidase
BM524_11470	COG2186	Transcriptional regulator
BM524_11480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM524_11485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM524_11495	COG2983	Belongs to the UPF0260 family
BM524_11500	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM524_11515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM524_11520	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_11525	COG2267	carboxylic ester hydrolase activity
BM524_11540	COG1214	PFAM Peptidase M22, glycoprotease
BM524_11545	COG1199	ATP-dependent helicase activity
BM524_11600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM524_11605	COG4771	TonB-dependent receptor
BM524_11615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM524_11620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM524_11625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM524_11630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM524_11630	COG0131	Imidazoleglycerol-phosphate dehydratase
BM524_11635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM524_11650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM524_11650	COG0140	phosphoribosyl-ATP diphosphatase activity
BM524_11655	COG2116	formate transmembrane transporter activity
BM524_11690	COG0326	Molecular chaperone. Has ATPase activity
BM524_11695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM524_11715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM524_11720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM524_11730	COG3220	belongs to the UPF0276 family
BM524_11750	COG2203	Gaf domain
BM524_11750	COG3706	GGDEF domain
BM524_11750	COG4251	negative regulation of phosphorylation
BM524_11750	COG5001	Diguanylate cyclase
BM524_11780	COG1183	phosphatidylcholine synthase activity
BM524_11800	COG0277	FAD linked oxidase domain protein
BM524_11805	COG0542	response to heat
BM524_11815	COG0564	pseudouridine synthase activity
BM524_11830	COG1595	DNA-templated transcription, initiation
BM524_11845	COG4221	oxidoreductase activity
BM524_11860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM524_11870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM524_11880	COG0142	geranyltranstransferase activity
BM524_11890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM524_11895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM524_11905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM524_11920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM524_11920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM524_11940	COG0488	(ABC) transporter
BM524_11950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM524_11960	COG0560	Phosphoserine phosphatase
BM524_11970	COG0084	hydrolase, TatD family'
BM524_11985	COG0571	ribonuclease III activity
BM524_11990	COG0681	Belongs to the peptidase S26 family
BM524_12015	COG1595	DNA-templated transcription, initiation
BM524_12020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM524_12035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM524_12115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM524_12120	COG1047	Peptidyl-prolyl cis-trans
BM524_12130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM524_12135	COG0196	riboflavin kinase activity
BM524_12140	COG0728	peptidoglycan biosynthetic process
BM524_12145	COG0268	Binds directly to 16S ribosomal RNA
BM524_12160	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_12165	COG0385	Bile acid
BM524_12170	COG0583	DNA-binding transcription factor activity
BM524_12200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_12205	COG0776	regulation of translation
BM524_12210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM524_12215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM524_12220	COG0740	serine-type endopeptidase activity
BM524_12225	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM524_12265	COG1720	tRNA m6t6A37 methyltransferase activity
BM524_12275	COG1234	tRNA 3'-trailer cleavage
BM524_12285	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM524_12300	COG0516	GMP reductase activity
BM524_12300	COG0517	IMP dehydrogenase activity
BM524_12305	COG1570	exodeoxyribonuclease VII activity
BM524_12325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM524_12330	COG2976	Protein conserved in bacteria
BM524_12355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM524_12365	COG2166	iron-sulfur cluster assembly
BM524_12380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM524_12385	COG0719	Fe-S assembly protein
BM524_12390	COG0396	ATPase activity
BM524_12395	COG0719	Fe-S assembly protein
BM524_12400	COG1104	cysteine desulfurase activity
BM524_12405	COG1959	2 iron, 2 sulfur cluster binding
BM524_12410	COG2072	flavoprotein involved in K transport
BM524_12415	COG1045	serine acetyltransferase
BM524_12420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM524_12425	COG0483	inositol monophosphate 1-phosphatase activity
BM524_12440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_12445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM524_12450	COG1862	Preprotein translocase
BM524_12455	COG0343	queuine tRNA-ribosyltransferase activity
BM524_12475	COG1842	Phage shock protein A
BM524_12480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM524_12500	COG0754	glutathionylspermidine amidase activity
BM524_12530	COG2066	Belongs to the glutaminase family
BM524_12535	COG1785	Belongs to the alkaline phosphatase family
BM524_12595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM524_12640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM524_12645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM524_12665	COG0297	glycogen (starch) synthase activity
BM524_12670	COG0367	asparagine synthase
BM524_12680	COG0463	Glycosyl transferase, family 2
BM524_12690	COG1216	Glycosyl transferase, family 2
BM524_12710	COG0367	asparagine synthase
BM524_12745	COG0489	protein tyrosine kinase activity
BM524_12755	COG3267	Type II secretory pathway component ExeA
BM524_12755	COG3409	Peptidoglycan-binding domain 1 protein
BM524_12760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM524_12760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM524_12790	COG1560	Kdo2-lipid A biosynthetic process
BM524_12805	COG1960	acyl-CoA dehydrogenase activity
BM524_12820	COG3300	MHYT domain
BM524_12820	COG5001	Diguanylate cyclase
BM524_12825	COG1435	thymidine kinase activity
BM524_12835	COG1609	Transcriptional regulator
BM524_12840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM524_12870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM524_12875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM524_12880	COG1024	Enoyl-CoA hydratase
BM524_12880	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM524_12895	COG1012	belongs to the aldehyde dehydrogenase family
BM524_12915	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM524_12920	COG0789	Transcriptional regulator
BM524_12950	COG1960	acyl-CoA dehydrogenase activity
BM524_12970	COG0745	RESPONSE REGULATOR receiver
BM524_12975	COG2205	protein histidine kinase activity
BM524_13015	COG2080	2 iron, 2 sulfur cluster binding
BM524_13020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BM524_13025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM524_13045	COG1028	Short-chain dehydrogenase reductase Sdr
BM524_13050	COG4221	oxidoreductase activity
BM524_13055	COG0693	protein deglycase activity
BM524_13060	COG1295	ribonuclease BN
BM524_13075	COG4681	YaeQ
BM524_13105	COG2814	Major facilitator Superfamily
BM524_13125	COG0514	ATP-dependent DNA helicase (RecQ)
BM524_13155	COG4251	negative regulation of phosphorylation
BM524_13160	COG2133	pyrroloquinoline quinone binding
BM524_13165	COG3609	addiction module antidote protein, CC2985 family
BM524_13230	COG2826	transposase and inactivated derivatives, IS30 family
BM524_13250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM524_13255	COG2971	BadF BadG BcrA BcrD
BM524_13260	COG0583	DNA-binding transcription factor activity
BM524_13265	COG1620	l-lactate permease
BM524_13285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_13290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM524_13295	COG0006	proline dipeptidase activity
BM524_13310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_13325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM524_13330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM524_13335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM524_13355	COG3313	Fe-S protein
BM524_13390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_13395	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_13400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM524_13405	COG2186	Transcriptional regulator
BM524_13415	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM524_13420	COG3577	Aspartyl protease
BM524_13425	COG0157	Belongs to the NadC ModD family
BM524_13435	COG1459	type II secretion system
BM524_13440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM524_13445	COG0237	dephospho-CoA kinase activity
BM524_13445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM524_13450	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM524_13460	COG3608	succinylglutamate desuccinylase aspartoacylase
BM524_13465	COG0494	nUDIX hydrolase
BM524_13475	COG0739	heme binding
BM524_13480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM524_13485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM524_13490	COG0849	cell division
BM524_13495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM524_13500	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM524_13505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM524_13515	COG0772	Belongs to the SEDS family
BM524_13520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM524_13530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM524_13535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM524_13540	COG0768	penicillin binding
BM524_13545	COG3116	cell division
BM524_13555	COG2001	Belongs to the MraZ family
BM524_13575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM524_13580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_13600	COG0678	peroxiredoxin activity
BM524_13600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM524_13615	COG3706	GGDEF domain
BM524_13625	COG2204	response regulator
BM524_13630	COG2205	protein histidine kinase activity
BM524_13630	COG0784	Response regulator, receiver
BM524_13645	COG2271	Major facilitator Superfamily
BM524_13670	COG0668	transmembrane transport
BM524_13675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM524_13680	COG0189	ligase activity
BM524_13685	COG1678	Uncharacterized ACR, COG1678
BM524_13690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM524_13715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM524_13720	COG0762	integral membrane protein
BM524_13730	COG1902	pentaerythritol trinitrate reductase activity
BM524_13730	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM524_13745	COG0625	glutathione transferase activity
BM524_13755	COG1764	response to oxidative stress
BM524_13760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM524_13775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BM524_13780	COG1396	sequence-specific DNA binding
BM524_13785	COG2814	Major facilitator Superfamily
BM524_13790	COG0724	RNA recognition motif
BM524_13815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BM524_13820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM524_13825	COG0083	homoserine kinase activity
BM524_13840	COG0583	DNA-binding transcription factor activity
BM524_13855	COG0640	Transcriptional regulator
BM524_13865	COG0431	NADPH-dependent FMN reductase
BM524_13870	COG0798	PFAM Bile acid sodium symporter
BM524_13875	COG2201	protein-glutamate methylesterase activity
BM524_13880	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM524_13890	COG3850	Histidine kinase
BM524_13890	COG5002	protein histidine kinase activity
BM524_13905	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BM524_13935	COG1748	Saccharopine dehydrogenase
BM524_13950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM524_13955	COG3107	peptidoglycan biosynthetic process
BM524_13975	COG2823	Periplasmic or secreted lipoprotein
BM524_14005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM524_14010	COG0372	Belongs to the citrate synthase family
BM524_14015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM524_14020	COG2828	Protein conserved in bacteria
BM524_14025	COG2199	diguanylate cyclase activity
BM524_14025	COG2203	Gaf domain
BM524_14045	COG5002	protein histidine kinase activity
BM524_14045	COG2198	Histidine kinase
BM524_14045	COG0784	Response regulator, receiver
BM524_14050	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM524_14055	COG0067	glutamate synthase
BM524_14055	COG0069	glutamate synthase activity
BM524_14055	COG0070	glutamate synthase
BM524_14060	COG0493	'glutamate synthase
BM524_14080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM524_14085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM524_14090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM524_14095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM524_14110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM524_14115	COG5507	3-demethylubiquinone-9 3-methyltransferase
BM524_14120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM524_14125	COG4942	peptidase
BM524_14130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM524_14135	COG0738	Major facilitator superfamily
BM524_14140	COG1902	pentaerythritol trinitrate reductase activity
BM524_14160	COG0625	glutathione transferase activity
BM524_14185	COG2894	cell division
BM524_14190	COG0850	regulation of cytokinetic process
BM524_14200	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BM524_14235	COG1914	H( )-stimulated, divalent metal cation uptake system
BM524_14240	COG0436	Aminotransferase
BM524_14255	COG0174	glutamine synthetase
BM524_14265	COG3852	Histidine kinase
BM524_14270	COG2204	response regulator
BM524_14275	COG3437	response regulator, receiver
BM524_14280	COG0204	Acyl-transferase
BM524_14295	COG3706	GGDEF domain
BM524_14315	COG3850	Histidine kinase
BM524_14315	COG4999	Histidine kinase
BM524_14315	COG3437	response regulator, receiver
BM524_14315	COG2205	protein histidine kinase activity
BM524_14320	COG0525	valine-tRNA ligase activity
BM524_14325	COG2927	DNA polymerase III (CHI subunit)
BM524_14330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM524_14335	COG0795	lipopolysaccharide-transporting ATPase activity
BM524_14340	COG0795	lipopolysaccharide-transporting ATPase activity
BM524_14410	COG3459	Glycosyltransferase 36 associated
BM524_14420	COG2203	Gaf domain
BM524_14420	COG2199	diguanylate cyclase activity
BM524_14450	COG0673	inositol 2-dehydrogenase activity
BM524_14455	COG2205	protein histidine kinase activity
BM524_14455	COG2198	Histidine kinase
BM524_14455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_14455	COG0784	Response regulator, receiver
BM524_14460	COG0628	permease
BM524_14475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM524_14480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM524_14485	COG4558	Periplasmic binding protein
BM524_14495	COG4206	TonB-dependent receptor
BM524_14505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM524_14510	COG0697	spore germination
BM524_14540	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM524_14550	COG0006	proline dipeptidase activity
BM524_14555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM524_14560	COG3706	GGDEF domain
BM524_14560	COG0745	RESPONSE REGULATOR receiver
BM524_14565	COG0679	Auxin Efflux Carrier
BM524_14575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM524_14585	COG0395	ABC-type sugar transport system, permease component
BM524_14605	COG2267	carboxylic ester hydrolase activity
BM524_14635	COG1131	(ABC) transporter
BM524_14645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM524_14695	COG2205	protein histidine kinase activity
BM524_14705	COG0348	domain, Protein
BM524_14705	COG3901	Regulator of nitric oxide reductase transcription
BM524_14715	COG2197	response regulator
BM524_14740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM524_14745	COG0277	FAD linked oxidase domain protein
BM524_14755	COG1462	curli production assembly transport component CsgG
BM524_14785	COG2197	response regulator
BM524_14810	COG0513	Belongs to the DEAD box helicase family
BM524_14815	COG5001	Diguanylate cyclase
BM524_14830	COG0800	Aldolase
BM524_14835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_14850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM524_14850	COG3264	Mechanosensitive ion channel
BM524_14890	COG0730	response to heat
BM524_14910	COG4191	Histidine kinase
BM524_14920	COG0417	DNA replication proofreading
BM524_14930	COG0318	PFAM AMP-dependent synthetase and ligase
BM524_14975	COG1309	transcriptional regulator
BM524_14985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_14995	COG1573	uracil-dna glycosylase
BM524_15000	COG5001	Diguanylate cyclase
BM524_15000	COG3300	MHYT domain
BM524_15020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM524_15040	COG1983	PspC domain protein
BM524_15045	COG1842	Phage shock protein A
BM524_15055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_15060	COG0582	viral genome integration into host DNA
BM524_15120	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BM524_15190	COG1621	beta-fructofuranosidase activity
BM524_15205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM524_15215	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM524_15220	COG0204	Acyl-transferase
BM524_15225	COG0204	Acyl-transferase
BM524_15230	COG0668	transmembrane transport
BM524_15245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM524_15250	COG0733	neurotransmitter:sodium symporter activity
BM524_15265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM524_15280	COG0716	FMN binding
BM524_15290	COG0848	biopolymer transport protein
BM524_15305	COG0457	Tetratricopeptide repeat
BM524_15310	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM524_15320	COG1215	transferase activity, transferring glycosyl groups
BM524_15335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM524_15340	COG0702	epimerase
BM524_15360	COG5001	Diguanylate cyclase
BM524_15360	COG5002	protein histidine kinase activity
BM524_15370	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM524_15380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_15390	COG0583	DNA-binding transcription factor activity
BM524_15395	COG0121	glutamine amidotransferase
BM524_15405	COG4682	membrane
BM524_15440	COG4628	conserved protein (DUF2132)
BM524_15445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM524_15455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM524_15470	COG1477	protein flavinylation
BM524_15475	COG2871	sodium ion transport
BM524_15480	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_15485	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_15490	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_15495	COG1805	sodium ion transport
BM524_15500	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM524_15505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM524_15510	COG0545	Peptidyl-prolyl cis-trans isomerase
BM524_15515	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM524_15530	COG0039	L-malate dehydrogenase activity
BM524_15535	COG1438	arginine binding
BM524_15560	COG0572	uridine kinase
BM524_15565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM524_15585	COG3706	GGDEF domain
BM524_15585	COG0745	RESPONSE REGULATOR receiver
BM524_15590	COG2176	DNA-directed DNA polymerase activity
BM524_15600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_15610	COG2205	protein histidine kinase activity
BM524_15620	COG0189	ligase activity
BM524_15630	COG0189	ligase activity
BM524_15630	COG4067	protein conserved in archaea
BM524_15655	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM524_15660	COG0667	Aldo Keto reductase
BM524_15685	COG0515	serine threonine protein kinase
BM524_15685	COG2815	serine threonine protein kinase
BM524_15770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BM524_15780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM524_15825	COG2274	protein secretion by the type I secretion system
BM524_15830	COG0583	DNA-binding transcription factor activity
BM524_15865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM524_15880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM524_15900	COG1063	alcohol dehydrogenase
BM524_15930	COG2244	polysaccharide biosynthetic process
BM524_15950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BM524_15960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM524_15965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM524_15980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM524_15995	COG0202	RNA polymerase activity
BM524_16020	COG0201	protein transport
BM524_16040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BM524_16075	COG5002	protein histidine kinase activity
BM524_16075	COG0784	Response regulator, receiver
BM524_16095	COG0557	exoribonuclease II activity
BM524_16130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM524_16145	COG0543	2 iron, 2 sulfur cluster binding
BM524_16155	COG2234	aminopeptidase activity
BM524_16165	COG4251	negative regulation of phosphorylation
BM524_16175	COG1271	oxidase subunit
BM524_16180	COG1294	oxidase, subunit
BM524_16185	COG1522	sequence-specific DNA binding
BM524_16195	COG1278	Cold shock
BM524_16200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM524_16220	COG0339	signal peptide processing
BM524_16225	COG2201	protein-glutamate methylesterase activity
BM524_16235	COG3852	Histidine kinase
BM524_16245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM524_16250	COG0243	molybdopterin cofactor binding
BM524_16255	COG0823	Involved in the tonB-independent uptake of proteins
BM524_16255	COG1506	peptidase
BM524_16255	COG4946	Tricorn protease homolog
BM524_16300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM524_16310	COG2197	response regulator
BM524_16340	COG1621	beta-fructofuranosidase activity
BM524_16345	COG2814	Major facilitator Superfamily
BM524_16355	COG4206	TonB-dependent receptor
BM524_16355	COG1629	transport
BM524_16365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM524_16370	COG1278	Cold shock
BM524_16375	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM524_16380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM524_16395	COG0281	malic enzyme
BM524_16405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM524_16435	COG0456	acetyltransferase
BM524_16445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM524_16450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM524_16455	COG2177	Part of the ABC transporter FtsEX involved in
BM524_16460	COG2884	Cell division ATP-binding protein ftsE
BM524_16465	COG0552	protein localization to endoplasmic reticulum
BM524_16475	COG0742	ribosomal rna small subunit methyltransferase
BM524_16485	COG2095	MarC family integral membrane protein
BM524_16510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM524_16515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM524_16520	COG0617	tRNA 3'-terminal CCA addition
BM524_16525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM524_16540	COG0076	glutamate decarboxylase activity
BM524_16555	COG0842	Transport permease protein
BM524_16560	COG1131	(ABC) transporter
BM524_16565	COG0745	RESPONSE REGULATOR receiver
BM524_16570	COG2205	protein histidine kinase activity
BM524_16575	COG4774	siderophore transport
BM524_16595	COG1253	flavin adenine dinucleotide binding
BM524_16605	COG1966	Carbon starvation protein
BM524_16630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM524_16635	COG0049	tRNA binding
BM524_16640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM524_16645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM524_16650	COG0085	RNA polymerase activity
BM524_16655	COG0222	ribosome binding
BM524_16660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM524_16665	COG0081	regulation of translation
BM524_16670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM524_16690	COG0250	Participates in transcription elongation, termination and antitermination
BM524_16695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM524_16705	COG1132	(ABC) transporter
BM524_16710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM524_16715	COG3590	peptidase
BM524_16725	COG0513	Belongs to the DEAD box helicase family
BM524_16730	COG0418	dihydroorotase activity
BM524_16735	COG3040	lipid binding
BM524_16740	COG4989	oxidoreductase activity
BM524_16745	COG0346	lactoylglutathione lyase activity
BM524_16750	COG0668	transmembrane transport
BM524_16770	COG0302	gtp cyclohydrolase
BM524_16780	COG2957	Belongs to the agmatine deiminase family
BM524_16785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM524_16795	COG1201	RNA secondary structure unwinding
BM524_16805	COG1793	dna ligase
BM524_16810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM524_16815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM524_16830	COG0625	glutathione transferase activity
BM524_16835	COG0625	glutathione transferase activity
BM524_16845	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM524_16860	COG1012	belongs to the aldehyde dehydrogenase family
BM524_16865	COG0028	Belongs to the TPP enzyme family
BM524_16875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM524_16880	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM524_16885	COG0330	HflC and HflK could
BM524_16890	COG0330	HflC and HflK could
BM524_16895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM524_16900	COG1923	regulation of RNA biosynthetic process
BM524_16905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM524_16920	COG0802	atpase or kinase
BM524_16925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM524_16925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM524_16930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM524_16940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM524_16950	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BM524_16955	COG0735	belongs to the Fur family
BM524_16965	COG0432	Pfam Uncharacterised protein family UPF0047
BM524_16975	COG0305	Participates in initiation and elongation during chromosome replication
BM524_17000	COG2258	MOSC domain
BM524_17060	COG0784	Response regulator, receiver
BM524_17060	COG2198	Histidine kinase
BM524_17060	COG2205	protein histidine kinase activity
BM524_17070	COG0577	efflux transmembrane transporter activity
BM524_17070	COG1136	(ABC) transporter
BM524_17080	COG0840	transmembrane signaling receptor activity
BM524_17085	COG5002	protein histidine kinase activity
BM524_17090	COG0840	transmembrane signaling receptor activity
BM524_17105	COG2855	membrane
BM524_17110	COG2175	clavaminate synthase activity
BM524_17115	COG0656	L-ascorbic acid biosynthetic process
BM524_17135	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM524_17140	COG4771	TonB-dependent receptor
BM524_17165	COG1472	Belongs to the glycosyl hydrolase 3 family
BM524_17175	COG2723	6-phospho-beta-galactosidase activity
BM524_17180	COG1609	Transcriptional regulator
BM524_17185	COG2814	Major facilitator Superfamily
BM524_17185	COG0477	Major facilitator Superfamily
BM524_17190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM524_17195	COG4988	ABC transporter
BM524_17200	COG4890	Cyd operon protein YbgT
BM524_17205	COG1294	oxidase, subunit
BM524_17245	COG4319	ketosteroid isomerase
BM524_17265	COG2375	cellular response to nickel ion
BM524_17270	COG3237	CsbD-like
BM524_17285	COG1595	DNA-templated transcription, initiation
BM524_17290	COG1404	Belongs to the peptidase S8 family
BM524_17315	COG0596	Alpha beta hydrolase
BM524_17315	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM524_17335	COG3038	cytochrome b561
BM524_17345	COG1252	NADH dehydrogenase
BM524_17360	COG0583	DNA-binding transcription factor activity
BM524_17365	COG2067	long-chain fatty acid transport protein
BM524_17370	COG2130	NADP-dependent
BM524_17375	COG3706	GGDEF domain
BM524_17375	COG4251	negative regulation of phosphorylation
BM524_17375	COG5001	Diguanylate cyclase
BM524_17375	COG2203	Gaf domain
BM524_17380	COG2205	protein histidine kinase activity
BM524_17380	COG0784	Response regulator, receiver
BM524_17390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM524_17395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM524_17400	COG1349	DNA-binding transcription factor activity
BM524_17405	COG0673	inositol 2-dehydrogenase activity
BM524_17420	COG0697	spore germination
BM524_17425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM524_17430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM524_17435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM524_17440	COG1166	arginine decarboxylase activity
BM524_17450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM524_17455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM524_17460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM524_17510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM524_17535	COG3866	Pectate lyase
BM524_17550	COG3030	protein affecting phage T7 exclusion by the F plasmid
BM524_17555	COG1324	tolerance protein
BM524_17560	COG4232	protein-disulfide reductase activity
BM524_17565	COG0739	heme binding
BM524_17570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM524_17575	COG0511	ligase activity, forming carbon-carbon bonds
BM524_17580	COG0439	Biotin carboxylase
BM524_17625	COG0154	amidase activity
BM524_17640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM524_17645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM524_17660	COG0151	Belongs to the GarS family
BM524_17680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM524_17685	COG3954	Phosphoribulokinase
BM524_17695	COG0745	RESPONSE REGULATOR receiver
BM524_17710	COG1501	Belongs to the glycosyl hydrolase 31 family
BM524_17720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM524_17730	COG3031	protein transport across the cell outer membrane
BM524_17740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_17745	COG1459	type II secretion system
BM524_17750	COG2165	general secretion pathway protein
BM524_17755	COG2165	general secretion pathway protein
BM524_17765	COG4795	General secretion pathway protein
BM524_17780	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM524_17800	COG1012	belongs to the aldehyde dehydrogenase family
BM524_17810	COG1011	Hydrolase
BM524_17815	COG0494	nUDIX hydrolase
BM524_17820	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM524_17835	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM524_17845	COG3089	Belongs to the UPF0270 family
BM524_17850	COG0429	hydrolase of the alpha beta-hydrolase fold
BM524_17860	COG0488	(ABC) transporter
BM524_17875	COG2900	Belongs to the SlyX family
BM524_17885	COG0545	Peptidyl-prolyl cis-trans isomerase
BM524_17895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM524_17900	COG2183	response to ionizing radiation
BM524_17920	COG0596	Alpha beta hydrolase
BM524_17925	COG1040	competence protein
BM524_17945	COG1794	racemase activity, acting on amino acids and derivatives
BM524_17960	COG0534	Mate efflux family protein
BM524_17965	COG0726	polysaccharide deacetylase
BM524_17965	COG1649	PFAM Uncharacterised BCR, COG1649
BM524_17975	COG1999	signal sequence binding
BM524_17980	COG0109	protoheme IX farnesyltransferase activity
BM524_17985	COG1612	heme a metabolic process
BM524_18005	COG1845	cytochrome c oxidase, subunit III
BM524_18010	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BM524_18015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM524_18020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM524_18030	COG3706	GGDEF domain
BM524_18045	COG0129	dihydroxy-acid dehydratase activity
BM524_18055	COG0606	chelatase, subunit chli
BM524_18060	COG0583	DNA-binding transcription factor activity
BM524_18070	COG2814	Major facilitator Superfamily
BM524_18075	COG1073	alpha beta
BM524_18080	COG0729	surface antigen
BM524_18085	COG2911	Protein conserved in bacteria
BM524_18110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM524_18120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM524_18140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM524_18165	COG1228	amidohydrolase
BM524_18190	COG0425	Belongs to the sulfur carrier protein TusA family
BM524_18205	COG1561	YicC-like family, N-terminal region
BM524_18265	COG2723	6-phospho-beta-galactosidase activity
BM524_18270	COG2211	Major facilitator Superfamily
BM524_18275	COG1609	Transcriptional regulator
BM524_18290	COG2199	diguanylate cyclase activity
BM524_18290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BM524_18315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM524_18335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM524_18340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM524_18360	COG1475	DNA binding
BM524_18365	COG1192	Involved in chromosome partitioning
BM524_18390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM524_18395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM524_18405	COG0706	membrane insertase activity
BM524_18410	COG0594	ribonuclease P activity
BM524_18415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BM524_18440	COG0551	DNA topoisomerase type I activity
BM524_18440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM524_18560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM524_18655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM524_19160	COG2813	Specifically methylates the guanine in position
BM524_19250	COG2755	lipolytic protein G-D-S-L family
BM524_19250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM524_19660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BM524_19665	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BM524_19765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_19820	COG4232	protein-disulfide reductase activity
BM524_19870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM524_19900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM524_19920	COG1104	cysteine desulfurase activity
BM524_19925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BM524_19950	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BM524_19985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_19995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM524_20050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM524_20100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_20125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM524_20140	COG0587	DNA-directed DNA polymerase activity
BM524_20170	COG3706	GGDEF domain
BM524_20215	COG0629	single-stranded DNA binding
BM524_20245	COG0776	regulation of translation
BM524_20450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM524_20455	COG1061	Type III restriction enzyme res subunit
BM524_20460	COG1002	Type II restriction enzyme, methylase subunits
BM524_20470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM524_20515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM524_20555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_20555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM524_20600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM524_20625	COG0475	glutathione-regulated potassium exporter activity
BM524_20625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM524_20675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM524_20680	COG0557	exoribonuclease II activity
BM524_20720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM524_20740	COG0497	DNA recombination
BM524_20920	COG1404	Belongs to the peptidase S8 family
BM524_20995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM524_21000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM524_21005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM524_21020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM524_21025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM524_21035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM524_21085	COG1596	polysaccharide export
BM524_21095	COG2204	response regulator
BM524_21100	COG4191	Histidine kinase
BM524_21100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM524_21110	COG0367	asparagine synthase
BM524_21120	COG1192	Involved in chromosome partitioning
BM524_21125	COG1475	DNA binding
BM524_21140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM524_21145	COG0489	protein tyrosine kinase activity
BM524_21155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM524_21170	COG0463	Glycosyl transferase, family 2
BM524_21175	COG0367	asparagine synthase
BM524_21185	COG2244	polysaccharide biosynthetic process
BM524_21195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_21220	COG2925	Exonuclease
BM524_21280	COG3706	GGDEF domain
BM524_21305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM524_21380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM524_21435	COG3706	GGDEF domain
BM524_21435	COG2203	Gaf domain
BM524_21435	COG5001	Diguanylate cyclase
BM524_21435	COG4251	negative regulation of phosphorylation
BM524_21505	COG0587	DNA-directed DNA polymerase activity