locus-tag	class	description
BM525_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM525_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM525_00020	COG0187	DNA topoisomerase II activity
BM525_00050	COG2818	Glycosylase
BM525_00060	COG3078	GTPase activator activity
BM525_00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM525_00080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM525_00085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BM525_00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM525_00095	COG0569	domain protein
BM525_00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM525_00100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM525_00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM525_00120	COG0758	DNA mediated transformation
BM525_00135	COG0009	L-threonylcarbamoyladenylate synthase
BM525_00140	COG0408	coproporphyrinogen oxidase activity
BM525_00145	COG3047	cAMP biosynthetic process
BM525_00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BM525_00230	COG2234	aminopeptidase activity
BM525_00235	COG3562	capsule polysaccharide
BM525_00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM525_00270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM525_00300	COG3642	lipopolysaccharide core region biosynthetic process
BM525_00305	COG0859	PFAM glycosyl transferase family 9
BM525_00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM525_00350	COG3161	chorismate lyase activity
BM525_00355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM525_00375	COG0210	DNA helicase
BM525_00420	COG1959	2 iron, 2 sulfur cluster binding
BM525_00425	COG0730	response to heat
BM525_00455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM525_00460	COG4988	ABC transporter
BM525_00470	COG1271	oxidase subunit
BM525_00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM525_00475	COG0425	Belongs to the sulfur carrier protein TusA family
BM525_00485	COG0450	alkyl hydroperoxide reductase
BM525_00490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM525_00520	COG3727	T/G mismatch-specific endonuclease activity
BM525_00545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM525_00550	COG0556	nucleotide-excision repair
BM525_00560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_00565	COG1129	ABC transporter
BM525_00565	COG0842	Transport permease protein
BM525_00570	COG0842	Transport permease protein
BM525_00580	COG4771	TonB-dependent receptor
BM525_00595	COG0583	DNA-binding transcription factor activity
BM525_00605	COG3106	COG3106 Predicted ATPase
BM525_00620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM525_00640	COG0352	thiamine-phosphate diphosphorylase activity
BM525_00650	COG3071	HemY protein
BM525_00655	COG2959	enzyme of heme biosynthesis
BM525_00665	COG0181	hydroxymethylbilane synthase activity
BM525_00670	COG3706	GGDEF domain
BM525_00670	COG0745	RESPONSE REGULATOR receiver
BM525_00680	COG0194	GDP metabolic process
BM525_00690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM525_00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM525_00705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM525_00715	COG0678	peroxiredoxin activity
BM525_00730	COG1178	ABC-type Fe3 transport system permease component
BM525_00735	COG3842	ATPase activity
BM525_00740	COG0668	transmembrane transport
BM525_00745	COG2081	HI0933 family
BM525_00755	COG2200	EAL domain
BM525_00760	COG0583	DNA-binding transcription factor activity
BM525_00770	COG2076	Multidrug Resistance protein
BM525_00785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_00800	COG0427	acetyl-CoA hydrolase
BM525_00805	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM525_00820	COG0840	transmembrane signaling receptor activity
BM525_00830	COG3064	Membrane
BM525_00840	COG5001	Diguanylate cyclase
BM525_00840	COG5002	protein histidine kinase activity
BM525_00855	COG0514	ATP-dependent DNA helicase (RecQ)
BM525_00860	COG2239	Acts as a magnesium transporter
BM525_00865	COG2962	Rard protein
BM525_00870	COG3706	GGDEF domain
BM525_00870	COG0745	RESPONSE REGULATOR receiver
BM525_00875	COG0210	DNA helicase
BM525_00885	COG1011	Hydrolase
BM525_00900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM525_00905	COG0019	diaminopimelate decarboxylase activity
BM525_00935	COG0163	prenyltransferase activity
BM525_00940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM525_00950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BM525_00970	COG1077	Cell shape determining protein MreB Mrl
BM525_00985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM525_00990	COG2814	Major facilitator Superfamily
BM525_00995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM525_01020	COG1085	galactose-1-phosphate uridylyltransferase
BM525_01025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BM525_01035	COG0629	single-stranded DNA binding
BM525_01060	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM525_01085	COG1349	DNA-binding transcription factor activity
BM525_01130	COG3267	Type II secretory pathway component ExeA
BM525_01130	COG3409	Peptidoglycan-binding domain 1 protein
BM525_01140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM525_01145	COG1459	type II secretion system
BM525_01190	COG1077	Cell shape determining protein MreB Mrl
BM525_01195	COG1792	Involved in formation and maintenance of cell shape
BM525_01200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BM525_01210	COG1530	ribonuclease E activity
BM525_01220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM525_01225	COG0312	modulator of DNA gyrase
BM525_01230	COG3028	Belongs to the UPF0307 family
BM525_01235	COG0312	modulator of DNA gyrase
BM525_01250	COG0745	RESPONSE REGULATOR receiver
BM525_01255	COG4191	Histidine kinase
BM525_01255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_01260	COG0297	glycogen (starch) synthase activity
BM525_01270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM525_01275	COG0596	Alpha beta hydrolase
BM525_01315	COG2814	Major facilitator Superfamily
BM525_01325	COG0745	RESPONSE REGULATOR receiver
BM525_01335	COG0835	chemotaxis
BM525_01350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM525_01365	COG0745	RESPONSE REGULATOR receiver
BM525_01370	COG0643	Histidine kinase
BM525_01370	COG2198	Histidine kinase
BM525_01375	COG0835	chemotaxis
BM525_01395	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BM525_01445	COG0546	phosphoglycolate phosphatase activity
BM525_01470	COG0673	inositol 2-dehydrogenase activity
BM525_01480	COG2211	Major facilitator Superfamily
BM525_01485	COG1082	Xylose isomerase domain protein TIM barrel
BM525_01505	COG1454	alcohol dehydrogenase
BM525_01575	COG0089	rRNA binding
BM525_01585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM525_01595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM525_01610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM525_01615	COG0438	transferase activity, transferring glycosyl groups
BM525_01625	COG1519	Transferase
BM525_01645	COG0840	transmembrane signaling receptor activity
BM525_01660	COG0788	formyltetrahydrofolate deformylase activity
BM525_01670	COG1643	Atp-dependent helicase
BM525_01675	COG2951	lytic endotransglycosylase activity
BM525_01680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM525_01690	COG2354	Protein conserved in bacteria
BM525_01700	COG4977	sequence-specific DNA binding
BM525_01715	COG0004	ammonium transporteR
BM525_01720	COG0405	Gamma-glutamyltransferase
BM525_01725	COG2837	iron assimilation
BM525_01740	COG0540	Belongs to the ATCase OTCase family
BM525_01765	COG0784	Response regulator, receiver
BM525_01765	COG5002	protein histidine kinase activity
BM525_01765	COG2205	protein histidine kinase activity
BM525_01780	COG5001	Diguanylate cyclase
BM525_01780	COG3300	MHYT domain
BM525_01790	COG1012	belongs to the aldehyde dehydrogenase family
BM525_01800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM525_01815	COG0180	Tryptophanyl-tRNA synthetase
BM525_01820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM525_01840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BM525_01850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM525_01885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM525_01890	COG0281	malic enzyme
BM525_01900	COG0625	glutathione transferase activity
BM525_01910	COG0753	catalase activity
BM525_01935	COG3300	MHYT domain
BM525_01935	COG5001	Diguanylate cyclase
BM525_01940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BM525_01940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM525_01950	COG0137	argininosuccinate synthase activity
BM525_01970	COG1803	Methylglyoxal synthase
BM525_01980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BM525_01995	COG0745	RESPONSE REGULATOR receiver
BM525_02000	COG2205	protein histidine kinase activity
BM525_02005	COG2267	carboxylic ester hydrolase activity
BM525_02010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM525_02020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM525_02030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM525_02035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM525_02040	COG4942	peptidase
BM525_02045	COG2861	carbohydrate metabolic process
BM525_02070	COG1162	GTPase activity
BM525_02075	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BM525_02105	COG0028	Belongs to the TPP enzyme family
BM525_02125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BM525_02130	COG0805	protein transport
BM525_02140	COG0084	hydrolase, TatD family'
BM525_02145	COG3706	GGDEF domain
BM525_02145	COG2203	Gaf domain
BM525_02145	COG4251	negative regulation of phosphorylation
BM525_02145	COG5001	Diguanylate cyclase
BM525_02155	COG0248	Ppx GppA phosphatase
BM525_02160	COG0513	Belongs to the DEAD box helicase family
BM525_02165	COG3118	belongs to the thioredoxin family
BM525_02170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BM525_02180	COG0784	Response regulator, receiver
BM525_02180	COG5002	protein histidine kinase activity
BM525_02185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BM525_02195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM525_02210	COG0783	Belongs to the Dps family
BM525_02215	COG2133	pyrroloquinoline quinone binding
BM525_02220	COG0823	Involved in the tonB-independent uptake of proteins
BM525_02220	COG1506	peptidase
BM525_02220	COG4946	Tricorn protease homolog
BM525_02230	COG3118	belongs to the thioredoxin family
BM525_02245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BM525_02255	COG1012	belongs to the aldehyde dehydrogenase family
BM525_02275	COG1757	Na H antiporter
BM525_02290	COG3876	Protein conserved in bacteria
BM525_02295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM525_02305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BM525_02315	COG0346	lactoylglutathione lyase activity
BM525_02340	COG2824	Alkylphosphonate utilization operon protein PhnA
BM525_02345	COG0454	-acetyltransferase
BM525_02365	COG3093	addiction module antidote protein HigA
BM525_02435	COG0183	Belongs to the thiolase family
BM525_02440	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM525_02440	COG1024	Enoyl-CoA hydratase
BM525_02450	COG0006	proline dipeptidase activity
BM525_02460	COG0142	geranyltranstransferase activity
BM525_02490	COG1388	LysM domain
BM525_02490	COG4942	peptidase
BM525_02495	COG1238	metal cluster binding
BM525_02505	COG0585	pseudouridine synthase activity
BM525_02510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM525_02520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BM525_02530	COG0840	transmembrane signaling receptor activity
BM525_02565	COG0494	nUDIX hydrolase
BM525_02570	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BM525_02575	COG0730	response to heat
BM525_02580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BM525_02585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM525_02590	COG2201	protein-glutamate methylesterase activity
BM525_02595	COG0745	RESPONSE REGULATOR receiver
BM525_02595	COG3706	GGDEF domain
BM525_02620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM525_02635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM525_02645	COG1648	precorrin-2 dehydrogenase activity
BM525_02645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM525_02650	COG0513	Belongs to the DEAD box helicase family
BM525_02665	COG1538	Outer membrane efflux protein
BM525_02670	COG0494	nUDIX hydrolase
BM525_02680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM525_02685	COG3150	esterase
BM525_02690	COG0187	DNA topoisomerase II activity
BM525_02700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM525_02725	COG1509	lysine 2,3-aminomutase activity
BM525_02735	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BM525_02750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM525_02755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM525_02770	COG0271	Belongs to the BolA IbaG family
BM525_02775	COG0671	phosphoesterase, PA-phosphatase related
BM525_02785	COG3707	response regulator
BM525_02800	COG0659	secondary active sulfate transmembrane transporter activity
BM525_02805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM525_02815	COG0243	molybdopterin cofactor binding
BM525_02820	COG1648	precorrin-2 dehydrogenase activity
BM525_02820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM525_02825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM525_02835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM525_02835	COG1116	anion transmembrane transporter activity
BM525_02845	COG1116	anion transmembrane transporter activity
BM525_02860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM525_02865	COG4206	TonB-dependent receptor
BM525_02870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BM525_02875	COG0348	domain, Protein
BM525_02890	COG1960	acyl-CoA dehydrogenase activity
BM525_02895	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_02905	COG4948	Mandelate Racemase Muconate Lactonizing
BM525_02920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_02925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM525_02945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM525_02950	COG0358	DNA primase activity
BM525_02955	COG1610	YqeY-like protein
BM525_02975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM525_02980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM525_02995	COG0537	adenosine 5'-monophosphoramidase activity
BM525_03010	COG3135	benzoate transporter
BM525_03015	COG1396	sequence-specific DNA binding
BM525_03020	COG2974	May be involved in recombination
BM525_03025	COG4191	Histidine kinase
BM525_03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_03030	COG0745	RESPONSE REGULATOR receiver
BM525_03035	COG5002	protein histidine kinase activity
BM525_03060	COG0811	peptide transport
BM525_03065	COG0811	peptide transport
BM525_03070	COG0848	biopolymer transport protein
BM525_03075	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BM525_03085	COG3437	response regulator, receiver
BM525_03095	COG0318	PFAM AMP-dependent synthetase and ligase
BM525_03105	COG2133	pyrroloquinoline quinone binding
BM525_03115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM525_03145	COG0527	aspartate kinase activity
BM525_03155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM525_03160	COG2967	ApaG domain
BM525_03170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM525_03175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM525_03180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BM525_03185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BM525_03195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM525_03215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM525_03230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM525_03235	COG3956	TIGRFAM MazG family protein
BM525_03260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM525_03265	COG0723	plastoquinol--plastocyanin reductase activity
BM525_03270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM525_03275	COG2857	Cytochrome c1
BM525_03280	COG0625	glutathione transferase activity
BM525_03285	COG2969	positive regulation of protein catabolic process
BM525_03300	COG0745	RESPONSE REGULATOR receiver
BM525_03305	COG2239	Acts as a magnesium transporter
BM525_03310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM525_03320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BM525_03330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BM525_03335	COG1137	ATPase activity
BM525_03340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BM525_03350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM525_03365	COG1127	ABC transporter
BM525_03370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM525_03375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM525_03380	COG2854	intermembrane phospholipid transfer
BM525_03390	COG5007	Belongs to the BolA IbaG family
BM525_03400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM525_03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM525_03415	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BM525_03450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM525_03465	COG4771	TonB-dependent receptor
BM525_03470	COG0697	spore germination
BM525_03475	COG0784	Response regulator, receiver
BM525_03475	COG2205	protein histidine kinase activity
BM525_03500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM525_03510	COG0126	phosphoglycerate kinase activity
BM525_03515	COG3588	fructose-bisphosphate aldolase
BM525_03525	COG0823	Involved in the tonB-independent uptake of proteins
BM525_03525	COG1506	peptidase
BM525_03525	COG4946	Tricorn protease homolog
BM525_03530	COG0248	Ppx GppA phosphatase
BM525_03535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM525_03545	COG0573	inorganic phosphate transmembrane transporter activity
BM525_03555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM525_03565	COG0306	phosphate transporter
BM525_03575	COG0583	DNA-binding transcription factor activity
BM525_03585	COG1272	protein, Hemolysin III
BM525_03590	COG1846	Transcriptional regulator
BM525_03595	COG1764	response to oxidative stress
BM525_03610	COG1739	Uncharacterized protein family UPF0029
BM525_03630	COG0583	DNA-binding transcription factor activity
BM525_03635	COG4989	oxidoreductase activity
BM525_03650	COG0420	3'-5' exonuclease activity
BM525_03655	COG0419	ATPase involved in DNA repair
BM525_03665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BM525_03690	COG2188	Transcriptional regulator
BM525_03700	COG2986	histidine ammonia-lyase
BM525_03725	COG0488	(ABC) transporter
BM525_03750	COG0668	transmembrane transport
BM525_03780	COG0582	viral genome integration into host DNA
BM525_03785	COG2319	Wd-40 repeat
BM525_03785	COG4249	Peptidase C14 caspase catalytic subunit p20
BM525_03825	COG1518	maintenance of DNA repeat elements
BM525_03830	COG1203	CRISPR-associated helicase, Cas3
BM525_03885	COG1346	cytolysis
BM525_03915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM525_03925	COG0513	Belongs to the DEAD box helicase family
BM525_03935	COG3409	Peptidoglycan-binding domain 1 protein
BM525_03935	COG3267	Type II secretory pathway component ExeA
BM525_03950	COG0066	3-isopropylmalate dehydratase activity
BM525_03960	COG0473	3-isopropylmalate dehydrogenase activity
BM525_03965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM525_03990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BM525_04005	COG4555	ABC transporter
BM525_04010	COG1668	transmembrane transport
BM525_04020	COG0745	RESPONSE REGULATOR receiver
BM525_04055	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM525_04060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM525_04065	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM525_04075	COG1138	Cytochrome C-type biogenesis protein
BM525_04080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM525_04095	COG2853	Lipoprotein
BM525_04100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM525_04110	COG3104	oligopeptide transport
BM525_04140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM525_04155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BM525_04160	COG1555	photosystem II stabilization
BM525_04160	COG1596	polysaccharide export
BM525_04165	COG0473	3-isopropylmalate dehydrogenase activity
BM525_04180	COG1611	Belongs to the LOG family
BM525_04185	COG3706	GGDEF domain
BM525_04185	COG0745	RESPONSE REGULATOR receiver
BM525_04190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM525_04190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM525_04245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BM525_04250	COG0024	Methionine aminopeptidase
BM525_04255	COG0052	Belongs to the universal ribosomal protein uS2 family
BM525_04265	COG0528	UMP kinase activity
BM525_04275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM525_04280	COG0575	Belongs to the CDS family
BM525_04305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM525_04325	COG0587	DNA-directed DNA polymerase activity
BM525_04330	COG0825	malonyl-CoA metabolic process
BM525_04335	COG0037	tRNA processing
BM525_04355	COG0590	tRNA wobble adenosine to inosine editing
BM525_04365	COG0047	phosphoribosylformylglycinamidine synthase activity
BM525_04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM525_04370	COG2840	Smr protein MutS2
BM525_04400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_04405	COG2197	response regulator
BM525_04445	COG0835	chemotaxis
BM525_04445	COG0784	Response regulator, receiver
BM525_04450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BM525_04455	COG1815	bacterial-type flagellum-dependent cell motility
BM525_04460	COG1558	bacterial-type flagellum-dependent cell motility
BM525_04465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BM525_04470	COG1749	Flagellar hook protein flgE
BM525_04475	COG4787	bacterial-type flagellum-dependent cell motility
BM525_04480	COG4786	Flagellar basal body rod
BM525_04495	COG3951	Flagellar rod assembly protein muramidase FlgJ
BM525_04495	COG1705	Flagellar rod assembly protein muramidase FlgJ
BM525_04500	COG1256	bacterial-type flagellum assembly
BM525_04525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BM525_04530	COG1334	flagellar protein FlaG
BM525_04535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BM525_04555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM525_04560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM525_04575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM525_04600	COG2089	acid synthase
BM525_04615	COG1083	cytidylyl-transferase
BM525_04635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM525_04650	COG2089	acid synthase
BM525_04660	COG1083	cytidylyl-transferase
BM525_04665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM525_04670	COG1086	Polysaccharide biosynthesis protein
BM525_04675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM525_04685	COG2204	response regulator
BM525_04690	COG3852	Histidine kinase
BM525_04695	COG2204	response regulator
BM525_04700	COG1677	Flagellar hook-basal body complex protein FliE
BM525_04705	COG1766	The M ring may be actively involved in energy transduction
BM525_04710	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BM525_04760	COG1987	bacterial-type flagellum assembly
BM525_04775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BM525_04785	COG0455	bacterial-type flagellum organization
BM525_04800	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BM525_04805	COG0643	Histidine kinase
BM525_04805	COG2198	Histidine kinase
BM525_04815	COG1192	Involved in chromosome partitioning
BM525_04825	COG0835	chemotaxis
BM525_04840	COG0646	methionine synthase
BM525_04840	COG1410	methionine synthase
BM525_04845	COG0646	methionine synthase
BM525_04845	COG1410	methionine synthase
BM525_04855	COG3123	guanosine phosphorylase activity
BM525_04865	COG0583	DNA-binding transcription factor activity
BM525_04870	COG0583	DNA-binding transcription factor activity
BM525_04880	COG0659	secondary active sulfate transmembrane transporter activity
BM525_04895	COG3590	peptidase
BM525_04905	COG2137	regulation of response to DNA damage stimulus
BM525_04910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM525_04940	COG5016	pyruvate
BM525_04940	COG0511	ligase activity, forming carbon-carbon bonds
BM525_04945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BM525_04950	COG4172	Belongs to the ABC transporter superfamily
BM525_04960	COG4171	peptide transport system, permease
BM525_04965	COG4168	peptide transport system, permease
BM525_04970	COG0747	negative chemotaxis
BM525_04975	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BM525_04980	COG1842	Phage shock protein A
BM525_05010	COG0625	glutathione transferase activity
BM525_05015	COG1522	sequence-specific DNA binding
BM525_05080	COG0811	peptide transport
BM525_05085	COG0811	peptide transport
BM525_05090	COG0848	biopolymer transport protein
BM525_05105	COG1444	tRNA N-acetyltransferase activity
BM525_05145	COG0456	acetyltransferase
BM525_05160	COG0583	DNA-binding transcription factor activity
BM525_05165	COG2814	Major facilitator Superfamily
BM525_05170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM525_05175	COG0656	L-ascorbic acid biosynthetic process
BM525_05185	COG3706	GGDEF domain
BM525_05185	COG0745	RESPONSE REGULATOR receiver
BM525_05215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM525_05260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM525_05265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM525_05270	COG0564	pseudouridine synthase activity
BM525_05280	COG0612	Peptidase, M16
BM525_05285	COG2918	glutathione biosynthetic process
BM525_05300	COG2840	Smr protein MutS2
BM525_05305	COG2890	protein-(glutamine-N5) methyltransferase activity
BM525_05320	COG2719	SpoVR family
BM525_05325	COG2718	Belongs to the UPF0229 family
BM525_05330	COG2766	serine protein kinase
BM525_05340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM525_05345	COG4771	TonB-dependent receptor
BM525_05370	COG0450	alkyl hydroperoxide reductase
BM525_05375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM525_05380	COG2885	chlorophyll binding
BM525_05385	COG0584	glycerophosphoryl diester phosphodiesterase
BM525_05390	COG0346	lactoylglutathione lyase activity
BM525_05395	COG1278	Cold shock
BM525_05410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM525_05415	COG4660	Part of a membrane complex involved in electron transport
BM525_05420	COG4659	FMN binding
BM525_05425	COG4658	electron transport chain
BM525_05430	COG4656	Part of a membrane complex involved in electron transport
BM525_05435	COG2878	Part of a membrane complex involved in electron transport
BM525_05455	COG0534	Mate efflux family protein
BM525_05460	COG0556	nucleotide-excision repair
BM525_05475	COG0602	queuosine metabolic process
BM525_05485	COG0367	asparagine synthase
BM525_05510	COG0471	metal ion transport
BM525_05510	COG3273	potassium ion transport
BM525_05525	COG0529	Catalyzes the synthesis of activated sulfate
BM525_05530	COG0175	sulfate reduction
BM525_05535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM525_05540	COG3706	GGDEF domain
BM525_05565	COG2304	oxidoreductase activity
BM525_05585	COG0714	Associated with various cellular activities
BM525_05595	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM525_05595	COG1024	Enoyl-CoA hydratase
BM525_05610	COG1025	Belongs to the peptidase M16 family
BM525_05615	COG2062	phosphohistidine phosphatase, SixA
BM525_05625	COG4536	flavin adenine dinucleotide binding
BM525_05630	COG4137	Cytochrome C assembly protein
BM525_05635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM525_05680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_05685	COG1132	(ABC) transporter
BM525_05700	COG0228	four-way junction DNA binding
BM525_05705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BM525_05710	COG0336	Belongs to the RNA methyltransferase TrmD family
BM525_05715	COG0335	large ribosomal subunit rRNA binding
BM525_05720	COG2860	membrane
BM525_05730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM525_05735	COG1605	Chorismate mutase
BM525_05735	COG0287	Prephenate dehydrogenase
BM525_05740	COG1605	Chorismate mutase
BM525_05740	COG0077	Prephenate dehydratase
BM525_05750	COG0023	Translation Initiation Factor
BM525_05780	COG2205	protein histidine kinase activity
BM525_05790	COG2204	response regulator
BM525_05810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM525_05815	COG0494	nUDIX hydrolase
BM525_05820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM525_05830	COG2255	four-way junction helicase activity
BM525_05835	COG0824	Thioesterase
BM525_05840	COG0811	peptide transport
BM525_05855	COG0823	Involved in the tonB-independent uptake of proteins
BM525_05860	COG2885	chlorophyll binding
BM525_05865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BM525_05885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BM525_05900	COG4667	esterase of the alpha-beta hydrolase superfamily
BM525_05905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BM525_05920	COG0300	oxidoreductase activity
BM525_05925	COG3038	cytochrome b561
BM525_05955	COG0583	DNA-binding transcription factor activity
BM525_05960	COG1064	alcohol dehydrogenase
BM525_05965	COG1451	nucleotide metabolic process
BM525_05970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM525_05980	COG1309	transcriptional regulator
BM525_05985	COG4774	siderophore transport
BM525_06005	COG3706	GGDEF domain
BM525_06015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BM525_06015	COG3008	intermembrane lipid transfer
BM525_06020	COG2995	paraquat-inducible protein a
BM525_06040	COG2207	Transcriptional regulator
BM525_06045	COG0017	Asparaginyl-tRNA synthetase
BM525_06060	COG0189	ligase activity
BM525_06090	COG0156	8-amino-7-oxononanoate synthase activity
BM525_06095	COG2226	methyltransferase
BM525_06105	COG3340	Belongs to the peptidase S51 family
BM525_06110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM525_06115	COG4139	cobalamin transport
BM525_06120	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BM525_06125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BM525_06140	COG5265	(ABC) transporter
BM525_06145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM525_06155	COG0745	RESPONSE REGULATOR receiver
BM525_06175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM525_06205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM525_06220	COG2755	lipolytic protein G-D-S-L family
BM525_06225	COG4181	ATPase activity
BM525_06230	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BM525_06235	COG1090	epimerase
BM525_06240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM525_06245	COG0628	permease
BM525_06255	COG0745	RESPONSE REGULATOR receiver
BM525_06270	COG2350	Protein conserved in bacteria
BM525_06275	COG0159	tryptophan synthase activity
BM525_06285	COG0135	phosphoribosylanthranilate isomerase activity
BM525_06285	COG0134	indole-3-glycerol-phosphate synthase activity
BM525_06290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM525_06300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM525_06305	COG0613	PHP domain protein
BM525_06310	COG0009	L-threonylcarbamoyladenylate synthase
BM525_06315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BM525_06320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BM525_06330	COG0656	L-ascorbic acid biosynthetic process
BM525_06335	COG0110	maltose O-acetyltransferase activity
BM525_06345	COG2733	membrane
BM525_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_06370	COG0500	methyltransferase
BM525_06375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM525_06380	COG0497	DNA recombination
BM525_06385	COG0783	Belongs to the Dps family
BM525_06395	COG1454	alcohol dehydrogenase
BM525_06400	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_06410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM525_06415	COG2610	gluconate transmembrane transporter activity
BM525_06430	COG2205	protein histidine kinase activity
BM525_06430	COG2198	Histidine kinase
BM525_06430	COG0784	Response regulator, receiver
BM525_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_06450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM525_06460	COG0484	heat shock protein binding
BM525_06465	COG3909	cytochrome
BM525_06485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM525_06490	COG0505	Belongs to the CarA family
BM525_06495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM525_06500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM525_06520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM525_06525	COG0857	belongs to the CobB CobQ family
BM525_06525	COG0280	phosphate acetyltransferase
BM525_06540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM525_06545	COG4535	Mg2 and Co2 transporter CorC
BM525_06555	COG1702	phosphate starvation-inducible protein PhoH
BM525_06565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM525_06595	COG1607	acyl-coa hydrolase
BM525_06600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM525_06610	COG1115	amino acid carrier protein
BM525_06645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM525_06650	COG0012	GTP binding
BM525_06665	COG1064	alcohol dehydrogenase
BM525_06680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM525_06690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM525_06695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BM525_06700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM525_06710	COG2890	protein-(glutamine-N5) methyltransferase activity
BM525_06715	COG0784	Response regulator, receiver
BM525_06715	COG3437	response regulator, receiver
BM525_06720	COG3094	Invasion gene expression up-regulator, SirB
BM525_06735	COG0583	DNA-binding transcription factor activity
BM525_06745	COG2363	Small membrane protein
BM525_06760	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM525_06765	COG0515	serine threonine protein kinase
BM525_06770	COG2116	formate transmembrane transporter activity
BM525_06785	COG0714	Associated with various cellular activities
BM525_06790	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BM525_06795	COG0033	Phosphoglucomutase
BM525_06800	COG0058	SHG alpha-glucan phosphorylase activity
BM525_06810	COG2988	succinylglutamate desuccinylase activity
BM525_06845	COG1393	Belongs to the ArsC family
BM525_06870	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BM525_06900	COG3300	MHYT domain
BM525_06900	COG5001	Diguanylate cyclase
BM525_06925	COG2249	NAD(P)H dehydrogenase (quinone) activity
BM525_06945	COG1733	regulation of RNA biosynthetic process
BM525_06950	COG3447	MASE1 domain protein
BM525_06950	COG5002	protein histidine kinase activity
BM525_06950	COG5001	Diguanylate cyclase
BM525_06960	COG0402	S-adenosylhomocysteine deaminase activity
BM525_06965	COG2351	hydroxyisourate hydrolase activity
BM525_06980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM525_06995	COG1309	transcriptional regulator
BM525_07010	COG2252	PERMEase
BM525_07015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BM525_07030	COG2203	Gaf domain
BM525_07030	COG4251	negative regulation of phosphorylation
BM525_07030	COG5001	Diguanylate cyclase
BM525_07030	COG3706	GGDEF domain
BM525_07035	COG2205	protein histidine kinase activity
BM525_07035	COG0784	Response regulator, receiver
BM525_07045	COG2233	PERMEase
BM525_07060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM525_07065	COG0730	response to heat
BM525_07105	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_07120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM525_07140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM525_07150	COG1596	polysaccharide export
BM525_07155	COG0489	protein tyrosine kinase activity
BM525_07160	COG4464	protein tyrosine phosphatase activity
BM525_07195	COG0297	glycogen (starch) synthase activity
BM525_07250	COG0438	transferase activity, transferring glycosyl groups
BM525_07260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM525_07260	COG2755	lipolytic protein G-D-S-L family
BM525_07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM525_07280	COG0072	phenylalanine-tRNA ligase activity
BM525_07305	COG1472	Belongs to the glycosyl hydrolase 3 family
BM525_07310	COG2096	Adenosyltransferase
BM525_07320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM525_07330	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM525_07355	COG0708	Exodeoxyribonuclease III
BM525_07390	COG2814	Major facilitator Superfamily
BM525_07430	COG1024	Enoyl-CoA hydratase
BM525_07435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BM525_07440	COG1960	acyl-CoA dehydrogenase activity
BM525_07445	COG0789	Transcriptional regulator
BM525_07450	COG0183	Belongs to the thiolase family
BM525_07465	COG3706	GGDEF domain
BM525_07475	COG2925	Exonuclease
BM525_07525	COG1643	Atp-dependent helicase
BM525_07545	COG0604	alcohol dehydrogenase
BM525_07545	COG3321	synthase
BM525_07550	COG0328	RNA-DNA hybrid ribonuclease activity
BM525_07555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BM525_07575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BM525_07585	COG4591	ABC-type transport system involved in lipoprotein release permease component
BM525_07600	COG3724	N-succinylarginine dihydrolase activity
BM525_07610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM525_07625	COG0746	molybdenum cofactor guanylyltransferase activity
BM525_07630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BM525_07635	COG0243	molybdopterin cofactor binding
BM525_07645	COG0625	glutathione transferase activity
BM525_07660	COG2153	protein acetylation
BM525_07675	COG1530	ribonuclease E activity
BM525_07695	COG1399	metal-binding, possibly nucleic acid-binding protein
BM525_07705	COG0416	fatty acid biosynthetic process
BM525_07710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM525_07715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM525_07725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM525_07730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM525_07740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BM525_07755	COG0084	hydrolase, TatD family'
BM525_07765	COG0702	epimerase
BM525_07770	COG3706	GGDEF domain
BM525_07770	COG0745	RESPONSE REGULATOR receiver
BM525_07790	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_07795	COG0596	Alpha beta hydrolase
BM525_07805	COG0183	Belongs to the thiolase family
BM525_07810	COG1960	acyl-CoA dehydrogenase activity
BM525_07830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM525_07840	COG0246	Mannitol dehydrogenase
BM525_07865	COG0668	transmembrane transport
BM525_07870	COG4771	TonB-dependent receptor
BM525_07900	COG3437	response regulator, receiver
BM525_07910	COG0195	Participates in both transcription termination and antitermination
BM525_07925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM525_07940	COG3300	MHYT domain
BM525_07940	COG5001	Diguanylate cyclase
BM525_07945	COG1187	pseudouridine synthase activity
BM525_07955	COG3153	acetyltransferase
BM525_07955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM525_07985	COG0450	alkyl hydroperoxide reductase
BM525_08030	COG1032	radical SAM domain protein
BM525_08045	COG4771	TonB-dependent receptor
BM525_08050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM525_08060	COG4134	Bacterial extracellular solute-binding protein
BM525_08070	COG4136	ATPase activity
BM525_08075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM525_08095	COG2203	Gaf domain
BM525_08095	COG4251	negative regulation of phosphorylation
BM525_08095	COG3706	GGDEF domain
BM525_08095	COG5001	Diguanylate cyclase
BM525_08115	COG0583	DNA-binding transcription factor activity
BM525_08135	COG1131	(ABC) transporter
BM525_08150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM525_08155	COG0385	Bile acid
BM525_08215	COG1902	pentaerythritol trinitrate reductase activity
BM525_08225	COG2867	negative regulation of translational initiation
BM525_08230	COG2914	Belongs to the UPF0125 (RnfH) family
BM525_08240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM525_08245	COG4771	TonB-dependent receptor
BM525_08250	COG0457	Tetratricopeptide repeat
BM525_08265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM525_08265	COG0574	Belongs to the PEP-utilizing enzyme family
BM525_08300	COG2850	peptidyl-arginine hydroxylation
BM525_08310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM525_08315	COG2915	High frequency lysogenization protein hflD homolog
BM525_08320	COG0482	sulfurtransferase activity
BM525_08325	COG1187	pseudouridine synthase activity
BM525_08335	COG1278	Cold shock
BM525_08340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM525_08345	COG0542	response to heat
BM525_08350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM525_08355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BM525_08360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BM525_08365	COG0492	ferredoxin-NADP+ reductase activity
BM525_08370	COG3092	negative regulation of chromosome organization
BM525_08375	COG3091	SprT-like family
BM525_08380	COG0616	signal peptide processing
BM525_08395	COG0778	Nitroreductase
BM525_08405	COG0252	asparaginase activity
BM525_08410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM525_08415	COG0321	lipoyl(octanoyl) transferase activity
BM525_08420	COG2921	Belongs to the UPF0250 family
BM525_08425	COG1686	Belongs to the peptidase S11 family
BM525_08430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM525_08435	COG0772	Belongs to the SEDS family
BM525_08440	COG0768	penicillin binding
BM525_08445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BM525_08450	COG0799	negative regulation of ribosome biogenesis
BM525_08460	COG1466	dna polymerase III delta subunit
BM525_08465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BM525_08470	COG0495	leucyl-tRNA aminoacylation
BM525_08480	COG1067	ATP-dependent peptidase activity
BM525_08485	COG0596	Alpha beta hydrolase
BM525_08490	COG3706	GGDEF domain
BM525_08500	COG1534	Rna-binding protein
BM525_08505	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BM525_08510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM525_08515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM525_08520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM525_08525	COG0149	triose-phosphate isomerase activity
BM525_08530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM525_08560	COG1597	lipid kinase activity
BM525_08560	COG1803	Methylglyoxal synthase
BM525_08570	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_08575	COG0561	phosphatase activity
BM525_08590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM525_08615	COG1185	polyribonucleotide nucleotidyltransferase activity
BM525_08790	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BM525_08795	COG1196	nuclear chromosome segregation
BM525_08805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM525_08820	COG1132	(ABC) transporter
BM525_08825	COG1663	tetraacyldisaccharide 4'-kinase activity
BM525_08860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BM525_08865	COG0435	Glutathione S-transferase
BM525_08870	COG1741	Belongs to the pirin family
BM525_08875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM525_08885	COG0372	Belongs to the citrate synthase family
BM525_08890	COG2009	succinate dehydrogenase
BM525_08895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BM525_08900	COG1053	succinate dehydrogenase
BM525_08905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BM525_08910	COG0567	Dehydrogenase, E1 component
BM525_08915	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM525_08965	COG4667	esterase of the alpha-beta hydrolase superfamily
BM525_08985	COG0366	Alpha amylase catalytic
BM525_09010	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_09015	COG2267	carboxylic ester hydrolase activity
BM525_09025	COG0616	signal peptide processing
BM525_09045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM525_09050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM525_09055	COG0386	Belongs to the glutathione peroxidase family
BM525_09060	COG2084	Dehydrogenase
BM525_09070	COG1960	acyl-CoA dehydrogenase activity
BM525_09075	COG1024	Enoyl-CoA hydratase
BM525_09080	COG2226	methyltransferase
BM525_09085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM525_09090	COG3083	sulfuric ester hydrolase activity
BM525_09095	COG3082	Protein of unknown function (DUF1414)
BM525_09100	COG3081	Nucleoid-associated protein
BM525_09130	COG3275	phosphorelay sensor kinase activity
BM525_09135	COG3279	Response regulator of the LytR AlgR family
BM525_09140	COG0205	6-phosphofructokinase activity
BM525_09150	COG0789	Transcriptional regulator
BM525_09200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_09200	COG2205	protein histidine kinase activity
BM525_09220	COG0513	Belongs to the DEAD box helicase family
BM525_09230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BM525_09235	COG0583	DNA-binding transcription factor activity
BM525_09255	COG1760	l-serine dehydratase
BM525_09275	COG1322	Protein conserved in bacteria
BM525_09280	COG1404	Belongs to the peptidase S8 family
BM525_09285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM525_09290	COG0022	dehydrogenase e1 component
BM525_09300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BM525_09305	COG0515	serine threonine protein kinase
BM525_09310	COG1946	Acyl-CoA thioesterase
BM525_09320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM525_09330	COG1956	GAF domain-containing protein
BM525_09345	COG0793	Belongs to the peptidase S41A family
BM525_09350	COG0733	neurotransmitter:sodium symporter activity
BM525_09360	COG0308	aminopeptidase N
BM525_09390	COG2902	Dehydrogenase
BM525_09395	COG0167	dihydroorotate dehydrogenase activity
BM525_09420	COG3130	regulation of translation
BM525_09425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM525_09435	COG0415	Belongs to the DNA photolyase family
BM525_09440	COG0415	Belongs to the DNA photolyase family
BM525_09445	COG0415	Belongs to the DNA photolyase family
BM525_09450	COG3046	protein related to deoxyribodipyrimidine photolyase
BM525_09465	COG4264	IucA IucC family
BM525_09470	COG0318	PFAM AMP-dependent synthetase and ligase
BM525_09475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM525_09480	COG1082	Xylose isomerase domain protein TIM barrel
BM525_09510	COG4974	Belongs to the 'phage' integrase family
BM525_09520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM525_09525	COG0589	response to stress
BM525_09535	COG0069	glutamate synthase activity
BM525_09550	COG2193	ferroxidase activity
BM525_09560	COG3278	Belongs to the heme-copper respiratory oxidase family
BM525_09575	COG2010	Cytochrome c
BM525_09600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM525_09605	COG0589	response to stress
BM525_09610	COG0037	tRNA processing
BM525_09615	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM525_09635	COG1280	lysine exporter protein (LysE YggA)
BM525_09640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BM525_09645	COG2897	thiosulfate sulfurtransferase activity
BM525_09650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BM525_09665	COG0670	Belongs to the BI1 family
BM525_09670	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BM525_09685	COG2920	part of a sulfur-relay system
BM525_09715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BM525_09725	COG0531	amino acid
BM525_09725	COG1674	ftsk spoiiie
BM525_09735	COG0686	Belongs to the AlaDH PNT family
BM525_09740	COG0284	orotidine-5'-phosphate decarboxylase activity
BM525_09745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BM525_09760	COG0776	regulation of translation
BM525_09765	COG0539	negative regulation of cytoplasmic translation
BM525_09770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM525_09775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM525_09780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BM525_09790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM525_09795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM525_09800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM525_09805	COG0633	Ferredoxin
BM525_09835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BM525_09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM525_09850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM525_09860	COG4783	chaperone-mediated protein folding
BM525_09870	COG1393	Belongs to the ArsC family
BM525_09885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BM525_09900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM525_09910	COG1960	acyl-CoA dehydrogenase activity
BM525_09935	COG0572	uridine kinase
BM525_09940	COG3769	mannosylglycerate metabolic process
BM525_09945	COG1215	transferase activity, transferring glycosyl groups
BM525_09950	COG0366	Alpha amylase catalytic
BM525_09960	COG0303	'Molybdopterin
BM525_09965	COG0534	Mate efflux family protein
BM525_09980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM525_09985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM525_10045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM525_10180	COG0405	Gamma-glutamyltransferase
BM525_10185	COG1024	Enoyl-CoA hydratase
BM525_10230	COG1448	Aminotransferase
BM525_10245	COG1671	Belongs to the UPF0178 family
BM525_10250	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_10255	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_10260	COG1960	acyl-CoA dehydrogenase activity
BM525_10265	COG0662	Cupin 2, conserved barrel domain protein
BM525_10265	COG2207	Transcriptional regulator
BM525_10270	COG4771	TonB-dependent receptor
BM525_10280	COG1505	serine-type exopeptidase activity
BM525_10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_10320	COG0596	Alpha beta hydrolase
BM525_10330	COG0716	FMN binding
BM525_10340	COG0735	belongs to the Fur family
BM525_10350	COG1984	allophanate hydrolase subunit 2
BM525_10355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BM525_10360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BM525_10365	COG2996	Protein conserved in bacteria
BM525_10370	COG1765	OsmC-like protein
BM525_10375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_10385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM525_10400	COG0436	Aminotransferase
BM525_10405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM525_10410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BM525_10435	COG3012	SEC-C Motif Domain Protein
BM525_10440	COG5002	protein histidine kinase activity
BM525_10440	COG3447	MASE1 domain protein
BM525_10440	COG5001	Diguanylate cyclase
BM525_10445	COG0366	Alpha amylase catalytic
BM525_10455	COG0604	alcohol dehydrogenase
BM525_10465	COG1960	acyl-CoA dehydrogenase activity
BM525_10475	COG4771	TonB-dependent receptor
BM525_10495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM525_10500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BM525_10520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM525_10530	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM525_10535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BM525_10545	COG2161	toxin-antitoxin pair type II binding
BM525_10550	COG4115	mRNA cleavage
BM525_10570	COG3268	Saccharopine dehydrogenase
BM525_10575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM525_10595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BM525_10600	COG4206	TonB-dependent receptor
BM525_10610	COG5006	permease, DMT superfamily
BM525_10625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM525_10630	COG1074	ATP-dependent DNA helicase activity
BM525_10635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BM525_10645	COG1022	Amp-dependent synthetase and ligase
BM525_10650	COG5001	Diguanylate cyclase
BM525_10670	COG0583	DNA-binding transcription factor activity
BM525_10685	COG0640	Transcriptional regulator
BM525_10705	COG2204	response regulator
BM525_10715	COG4251	negative regulation of phosphorylation
BM525_10720	COG0784	Response regulator, receiver
BM525_10725	COG0784	Response regulator, receiver
BM525_10725	COG2205	protein histidine kinase activity
BM525_10750	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BM525_10775	COG3139	Protein of unknown function (DUF1315)
BM525_10790	COG1115	amino acid carrier protein
BM525_10795	COG2866	Carboxypeptidase
BM525_10815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM525_10825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM525_10830	COG1640	4-alpha-glucanotransferase
BM525_10835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM525_10840	COG0676	glucose-6-phosphate 1-epimerase activity
BM525_10845	COG0800	Aldolase
BM525_10855	COG0129	dihydroxy-acid dehydratase activity
BM525_10865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM525_10870	COG1737	Transcriptional regulator
BM525_10875	COG0469	pyruvate kinase activity
BM525_10880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM525_10895	COG2823	Periplasmic or secreted lipoprotein
BM525_10925	COG3665	Urea carboxylase-associated protein
BM525_10945	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_10960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BM525_10975	COG2721	sulfolactate sulfo-lyase activity
BM525_10980	COG1904	glucuronate isomerase
BM525_10985	COG0246	Mannitol dehydrogenase
BM525_10990	COG0800	Aldolase
BM525_10995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM525_11010	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BM525_11035	COG2356	endonuclease I
BM525_11040	COG0840	transmembrane signaling receptor activity
BM525_11055	COG0583	DNA-binding transcription factor activity
BM525_11060	COG1979	alcohol dehydrogenase
BM525_11065	COG5001	Diguanylate cyclase
BM525_11075	COG3437	response regulator, receiver
BM525_11075	COG0784	Response regulator, receiver
BM525_11080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_11080	COG4191	Histidine kinase
BM525_11095	COG0471	metal ion transport
BM525_11105	COG0489	protein tyrosine kinase activity
BM525_11110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM525_11110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM525_11115	COG0668	transmembrane transport
BM525_11120	COG2226	methyltransferase
BM525_11125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM525_11130	COG1388	LysM domain
BM525_11130	COG0741	lytic transglycosylase activity
BM525_11150	COG0215	cysteine-tRNA ligase activity
BM525_11155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM525_11160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM525_11170	COG2268	Band 7 protein
BM525_11185	COG1733	regulation of RNA biosynthetic process
BM525_11190	COG0604	alcohol dehydrogenase
BM525_11200	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_11205	COG0753	catalase activity
BM525_11210	COG0604	alcohol dehydrogenase
BM525_11215	COG0583	DNA-binding transcription factor activity
BM525_11250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM525_11255	COG1286	toxin biosynthetic process
BM525_11260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BM525_11265	COG0285	dihydrofolate synthase activity
BM525_11285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM525_11290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM525_11310	COG3609	addiction module antidote protein, CC2985 family
BM525_11315	COG0583	DNA-binding transcription factor activity
BM525_11320	COG0697	spore germination
BM525_11335	COG2080	2 iron, 2 sulfur cluster binding
BM525_11355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM525_11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM525_11370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM525_11405	COG0789	Transcriptional regulator
BM525_11410	COG0604	alcohol dehydrogenase
BM525_11435	COG1119	ATPase activity
BM525_11440	COG2031	fatty acid transporter
BM525_11445	COG5002	protein histidine kinase activity
BM525_11445	COG2205	protein histidine kinase activity
BM525_11445	COG0784	Response regulator, receiver
BM525_11455	COG0612	Peptidase, M16
BM525_11470	COG3101	peptidyl-lysine hydroxylation
BM525_11495	COG1902	pentaerythritol trinitrate reductase activity
BM525_11495	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM525_11520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BM525_11530	COG4399	Belongs to the UPF0754 family
BM525_11555	COG1770	oligopeptidase
BM525_11560	COG2186	Transcriptional regulator
BM525_11570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BM525_11575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM525_11585	COG2983	Belongs to the UPF0260 family
BM525_11590	COG0179	Fumarylacetoacetate (FAA) hydrolase
BM525_11605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BM525_11610	COG0318	PFAM AMP-dependent synthetase and ligase
BM525_11615	COG2267	carboxylic ester hydrolase activity
BM525_11630	COG1214	PFAM Peptidase M22, glycoprotease
BM525_11635	COG1199	ATP-dependent helicase activity
BM525_11685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BM525_11690	COG4771	TonB-dependent receptor
BM525_11700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM525_11705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM525_11710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM525_11715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BM525_11715	COG0131	Imidazoleglycerol-phosphate dehydratase
BM525_11720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM525_11735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM525_11735	COG0140	phosphoribosyl-ATP diphosphatase activity
BM525_11740	COG2116	formate transmembrane transporter activity
BM525_11780	COG0326	Molecular chaperone. Has ATPase activity
BM525_11785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM525_11865	COG0582	viral genome integration into host DNA
BM525_11885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM525_11890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BM525_11900	COG3220	belongs to the UPF0276 family
BM525_11910	COG1136	(ABC) transporter
BM525_11910	COG0577	efflux transmembrane transporter activity
BM525_11920	COG5001	Diguanylate cyclase
BM525_11920	COG4251	negative regulation of phosphorylation
BM525_11920	COG3706	GGDEF domain
BM525_11920	COG2203	Gaf domain
BM525_11950	COG1183	phosphatidylcholine synthase activity
BM525_11970	COG0277	FAD linked oxidase domain protein
BM525_11975	COG0542	response to heat
BM525_11985	COG0564	pseudouridine synthase activity
BM525_12000	COG1595	DNA-templated transcription, initiation
BM525_12015	COG4221	oxidoreductase activity
BM525_12030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BM525_12040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BM525_12050	COG0142	geranyltranstransferase activity
BM525_12060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BM525_12065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM525_12075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM525_12090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM525_12090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM525_12110	COG0488	(ABC) transporter
BM525_12120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM525_12130	COG0560	Phosphoserine phosphatase
BM525_12140	COG0084	hydrolase, TatD family'
BM525_12155	COG0571	ribonuclease III activity
BM525_12160	COG0681	Belongs to the peptidase S26 family
BM525_12185	COG1595	DNA-templated transcription, initiation
BM525_12190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM525_12205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BM525_12285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM525_12290	COG1047	Peptidyl-prolyl cis-trans
BM525_12300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM525_12305	COG0196	riboflavin kinase activity
BM525_12310	COG0728	peptidoglycan biosynthetic process
BM525_12315	COG0268	Binds directly to 16S ribosomal RNA
BM525_12330	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_12335	COG0385	Bile acid
BM525_12340	COG0583	DNA-binding transcription factor activity
BM525_12365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM525_12370	COG0776	regulation of translation
BM525_12375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM525_12380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM525_12385	COG0740	serine-type endopeptidase activity
BM525_12390	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM525_12445	COG1720	tRNA m6t6A37 methyltransferase activity
BM525_12455	COG1234	tRNA 3'-trailer cleavage
BM525_12465	COG0123	including yeast histone deacetylase and acetoin utilization protein
BM525_12480	COG0516	GMP reductase activity
BM525_12480	COG0517	IMP dehydrogenase activity
BM525_12485	COG1570	exodeoxyribonuclease VII activity
BM525_12505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BM525_12510	COG2976	Protein conserved in bacteria
BM525_12535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM525_12545	COG2166	iron-sulfur cluster assembly
BM525_12560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM525_12565	COG0719	Fe-S assembly protein
BM525_12570	COG0396	ATPase activity
BM525_12575	COG0719	Fe-S assembly protein
BM525_12580	COG1104	cysteine desulfurase activity
BM525_12585	COG1959	2 iron, 2 sulfur cluster binding
BM525_12590	COG2072	flavoprotein involved in K transport
BM525_12595	COG1045	serine acetyltransferase
BM525_12600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM525_12605	COG0483	inositol monophosphate 1-phosphatase activity
BM525_12620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM525_12625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM525_12630	COG1862	Preprotein translocase
BM525_12635	COG0343	queuine tRNA-ribosyltransferase activity
BM525_12655	COG1842	Phage shock protein A
BM525_12660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM525_12680	COG0754	glutathionylspermidine amidase activity
BM525_12710	COG2066	Belongs to the glutaminase family
BM525_12715	COG1785	Belongs to the alkaline phosphatase family
BM525_12750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM525_12785	COG2171	N-acyltransferase activity
BM525_12805	COG0438	transferase activity, transferring glycosyl groups
BM525_12820	COG0367	asparagine synthase
BM525_12825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM525_12825	COG2755	lipolytic protein G-D-S-L family
BM525_12830	COG0438	transferase activity, transferring glycosyl groups
BM525_12855	COG2244	polysaccharide biosynthetic process
BM525_12915	COG0489	protein tyrosine kinase activity
BM525_12925	COG3267	Type II secretory pathway component ExeA
BM525_12925	COG3409	Peptidoglycan-binding domain 1 protein
BM525_12930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BM525_12930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BM525_12960	COG1560	Kdo2-lipid A biosynthetic process
BM525_12975	COG1960	acyl-CoA dehydrogenase activity
BM525_12990	COG5001	Diguanylate cyclase
BM525_12990	COG3300	MHYT domain
BM525_12995	COG1435	thymidine kinase activity
BM525_13005	COG1609	Transcriptional regulator
BM525_13010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM525_13040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM525_13045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM525_13050	COG1250	3-hydroxyacyl-CoA dehydrogenase
BM525_13050	COG1024	Enoyl-CoA hydratase
BM525_13065	COG1012	belongs to the aldehyde dehydrogenase family
BM525_13085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BM525_13090	COG0789	Transcriptional regulator
BM525_13120	COG1960	acyl-CoA dehydrogenase activity
BM525_13140	COG0745	RESPONSE REGULATOR receiver
BM525_13145	COG2205	protein histidine kinase activity
BM525_13190	COG2080	2 iron, 2 sulfur cluster binding
BM525_13195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BM525_13200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BM525_13220	COG1028	Short-chain dehydrogenase reductase Sdr
BM525_13225	COG4221	oxidoreductase activity
BM525_13230	COG0693	protein deglycase activity
BM525_13235	COG1295	ribonuclease BN
BM525_13250	COG4681	YaeQ
BM525_13280	COG2814	Major facilitator Superfamily
BM525_13300	COG0514	ATP-dependent DNA helicase (RecQ)
BM525_13325	COG3706	GGDEF domain
BM525_13340	COG4251	negative regulation of phosphorylation
BM525_13345	COG2133	pyrroloquinoline quinone binding
BM525_13370	COG3177	Filamentation induced by cAMP protein fic
BM525_13405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BM525_13410	COG2971	BadF BadG BcrA BcrD
BM525_13415	COG0583	DNA-binding transcription factor activity
BM525_13420	COG1620	l-lactate permease
BM525_13445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM525_13450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BM525_13455	COG0006	proline dipeptidase activity
BM525_13470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM525_13485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM525_13490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM525_13495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM525_13515	COG3313	Fe-S protein
BM525_13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM525_13555	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM525_13560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BM525_13565	COG2186	Transcriptional regulator
BM525_13575	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM525_13580	COG3577	Aspartyl protease
BM525_13585	COG0157	Belongs to the NadC ModD family
BM525_13590	COG4969	Belongs to the N-Me-Phe pilin family
BM525_13595	COG1459	type II secretion system
BM525_13600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM525_13605	COG0237	dephospho-CoA kinase activity
BM525_13605	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BM525_13610	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BM525_13620	COG3608	succinylglutamate desuccinylase aspartoacylase
BM525_13635	COG0739	heme binding
BM525_13640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BM525_13645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM525_13650	COG0849	cell division
BM525_13655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BM525_13660	COG1181	Belongs to the D-alanine--D-alanine ligase family
BM525_13665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM525_13675	COG0772	Belongs to the SEDS family
BM525_13680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM525_13690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM525_13695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM525_13700	COG0768	penicillin binding
BM525_13705	COG3116	cell division
BM525_13715	COG2001	Belongs to the MraZ family
BM525_13740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_13760	COG0678	peroxiredoxin activity
BM525_13760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM525_13775	COG3706	GGDEF domain
BM525_13785	COG2204	response regulator
BM525_13790	COG0784	Response regulator, receiver
BM525_13790	COG2205	protein histidine kinase activity
BM525_13805	COG2271	Major facilitator Superfamily
BM525_13830	COG0668	transmembrane transport
BM525_13835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BM525_13840	COG0189	ligase activity
BM525_13845	COG1678	Uncharacterized ACR, COG1678
BM525_13850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM525_13875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM525_13880	COG0762	integral membrane protein
BM525_13890	COG1902	pentaerythritol trinitrate reductase activity
BM525_13890	COG0446	pyridine nucleotide-disulphide oxidoreductase
BM525_13905	COG0625	glutathione transferase activity
BM525_13915	COG1764	response to oxidative stress
BM525_13920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM525_13935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BM525_13945	COG2814	Major facilitator Superfamily
BM525_13950	COG0724	RNA recognition motif
BM525_13975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BM525_13980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM525_14000	COG0583	DNA-binding transcription factor activity
BM525_14015	COG0640	Transcriptional regulator
BM525_14025	COG0431	NADPH-dependent FMN reductase
BM525_14030	COG0798	PFAM Bile acid sodium symporter
BM525_14035	COG2201	protein-glutamate methylesterase activity
BM525_14040	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BM525_14050	COG3850	Histidine kinase
BM525_14050	COG5002	protein histidine kinase activity
BM525_14065	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BM525_14095	COG1748	Saccharopine dehydrogenase
BM525_14110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM525_14115	COG3107	peptidoglycan biosynthetic process
BM525_14135	COG2823	Periplasmic or secreted lipoprotein
BM525_14155	COG4585	Histidine kinase
BM525_14160	COG2197	response regulator
BM525_14185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BM525_14190	COG0372	Belongs to the citrate synthase family
BM525_14195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BM525_14200	COG2828	Protein conserved in bacteria
BM525_14205	COG2203	Gaf domain
BM525_14205	COG2199	diguanylate cyclase activity
BM525_14225	COG0784	Response regulator, receiver
BM525_14225	COG2198	Histidine kinase
BM525_14225	COG5002	protein histidine kinase activity
BM525_14230	COG3023	N-Acetylmuramoyl-L-alanine amidase
BM525_14235	COG0067	glutamate synthase
BM525_14235	COG0070	glutamate synthase
BM525_14235	COG0069	glutamate synthase activity
BM525_14240	COG0493	'glutamate synthase
BM525_14260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BM525_14265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM525_14270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BM525_14275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM525_14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM525_14295	COG5507	3-demethylubiquinone-9 3-methyltransferase
BM525_14300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM525_14305	COG4942	peptidase
BM525_14310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM525_14315	COG0738	Major facilitator superfamily
BM525_14345	COG0625	glutathione transferase activity
BM525_14370	COG2894	cell division
BM525_14375	COG0850	regulation of cytokinetic process
BM525_14385	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BM525_14420	COG1914	H( )-stimulated, divalent metal cation uptake system
BM525_14425	COG0436	Aminotransferase
BM525_14440	COG0174	glutamine synthetase
BM525_14450	COG3852	Histidine kinase
BM525_14455	COG2204	response regulator
BM525_14460	COG3437	response regulator, receiver
BM525_14465	COG0204	Acyl-transferase
BM525_14480	COG3706	GGDEF domain
BM525_14500	COG3437	response regulator, receiver
BM525_14500	COG2205	protein histidine kinase activity
BM525_14500	COG4999	Histidine kinase
BM525_14500	COG3850	Histidine kinase
BM525_14505	COG0525	valine-tRNA ligase activity
BM525_14510	COG2927	DNA polymerase III (CHI subunit)
BM525_14515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM525_14520	COG0795	lipopolysaccharide-transporting ATPase activity
BM525_14525	COG0795	lipopolysaccharide-transporting ATPase activity
BM525_14600	COG3459	Glycosyltransferase 36 associated
BM525_14610	COG2203	Gaf domain
BM525_14610	COG2199	diguanylate cyclase activity
BM525_14640	COG0673	inositol 2-dehydrogenase activity
BM525_14645	COG5002	protein histidine kinase activity
BM525_14650	COG0628	permease
BM525_14665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BM525_14670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BM525_14675	COG4558	Periplasmic binding protein
BM525_14685	COG4206	TonB-dependent receptor
BM525_14695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM525_14700	COG0697	spore germination
BM525_14730	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM525_14740	COG0006	proline dipeptidase activity
BM525_14745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM525_14750	COG0745	RESPONSE REGULATOR receiver
BM525_14750	COG3706	GGDEF domain
BM525_14755	COG0679	Auxin Efflux Carrier
BM525_14765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM525_14775	COG0395	ABC-type sugar transport system, permease component
BM525_14795	COG2267	carboxylic ester hydrolase activity
BM525_14825	COG1131	(ABC) transporter
BM525_14835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM525_14885	COG2205	protein histidine kinase activity
BM525_14895	COG3901	Regulator of nitric oxide reductase transcription
BM525_14895	COG0348	domain, Protein
BM525_14905	COG2197	response regulator
BM525_14940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BM525_14945	COG0277	FAD linked oxidase domain protein
BM525_14955	COG1462	curli production assembly transport component CsgG
BM525_14985	COG2197	response regulator
BM525_15010	COG0513	Belongs to the DEAD box helicase family
BM525_15015	COG5001	Diguanylate cyclase
BM525_15025	COG0800	Aldolase
BM525_15030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM525_15045	COG3264	Mechanosensitive ion channel
BM525_15045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM525_15085	COG0730	response to heat
BM525_15105	COG4191	Histidine kinase
BM525_15115	COG0417	DNA replication proofreading
BM525_15125	COG0318	PFAM AMP-dependent synthetase and ligase
BM525_15165	COG1309	transcriptional regulator
BM525_15175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM525_15185	COG1573	uracil-dna glycosylase
BM525_15190	COG3300	MHYT domain
BM525_15190	COG5001	Diguanylate cyclase
BM525_15210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM525_15230	COG1983	PspC domain protein
BM525_15235	COG1842	Phage shock protein A
BM525_15245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM525_15270	COG1621	beta-fructofuranosidase activity
BM525_15295	COG0438	transferase activity, transferring glycosyl groups
BM525_15325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BM525_15335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM525_15340	COG0204	Acyl-transferase
BM525_15345	COG0204	Acyl-transferase
BM525_15350	COG0668	transmembrane transport
BM525_15365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM525_15370	COG0733	neurotransmitter:sodium symporter activity
BM525_15385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM525_15400	COG0716	FMN binding
BM525_15410	COG0848	biopolymer transport protein
BM525_15420	COG0457	Tetratricopeptide repeat
BM525_15425	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BM525_15435	COG1215	transferase activity, transferring glycosyl groups
BM525_15450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BM525_15455	COG0702	epimerase
BM525_15470	COG5001	Diguanylate cyclase
BM525_15470	COG5002	protein histidine kinase activity
BM525_15480	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BM525_15490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM525_15500	COG0583	DNA-binding transcription factor activity
BM525_15505	COG0121	glutamine amidotransferase
BM525_15515	COG4682	membrane
BM525_15535	COG1953	Uracil, thiamine, allantoin
BM525_15540	COG4771	TonB-dependent receptor
BM525_15550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM525_15560	COG0596	Alpha beta hydrolase
BM525_15565	COG0251	oxidation-reduction process
BM525_15570	COG1335	isochorismatase
BM525_15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM525_15580	COG1309	transcriptional regulator
BM525_15595	COG4628	conserved protein (DUF2132)
BM525_15615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BM525_15620	COG1609	Transcriptional regulator
BM525_15625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM525_15635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BM525_15655	COG1477	protein flavinylation
BM525_15660	COG2871	sodium ion transport
BM525_15665	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM525_15670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM525_15675	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM525_15680	COG1805	sodium ion transport
BM525_15685	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BM525_15690	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM525_15695	COG0545	Peptidyl-prolyl cis-trans isomerase
BM525_15700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM525_15715	COG0039	L-malate dehydrogenase activity
BM525_15720	COG1438	arginine binding
BM525_15745	COG0572	uridine kinase
BM525_15750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM525_15770	COG0745	RESPONSE REGULATOR receiver
BM525_15770	COG3706	GGDEF domain
BM525_15775	COG2176	DNA-directed DNA polymerase activity
BM525_15785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM525_15795	COG2205	protein histidine kinase activity
BM525_15805	COG0189	ligase activity
BM525_15815	COG0189	ligase activity
BM525_15815	COG4067	protein conserved in archaea
BM525_15840	COG1283	sodium-dependent phosphate transmembrane transporter activity
BM525_15845	COG0667	Aldo Keto reductase
BM525_15870	COG0515	serine threonine protein kinase
BM525_15870	COG2815	serine threonine protein kinase
BM525_15960	COG2274	protein secretion by the type I secretion system
BM525_15965	COG0583	DNA-binding transcription factor activity
BM525_16000	COG0438	transferase activity, transferring glycosyl groups
BM525_16000	COG1216	Glycosyl transferase, family 2
BM525_16010	COG1091	dTDP-4-dehydrorhamnose reductase activity
BM525_16030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM525_16070	COG0463	Glycosyl transferase, family 2
BM525_16075	COG2089	acid synthase
BM525_16090	COG1083	cytidylyl-transferase
BM525_16095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM525_16100	COG1086	Polysaccharide biosynthesis protein
BM525_16125	COG0202	RNA polymerase activity
BM525_16150	COG0201	protein transport
BM525_16170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BM525_16205	COG0784	Response regulator, receiver
BM525_16205	COG5002	protein histidine kinase activity
BM525_16225	COG0557	exoribonuclease II activity
BM525_16245	COG4771	TonB-dependent receptor
BM525_16260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BM525_16285	COG2234	aminopeptidase activity
BM525_16295	COG4251	negative regulation of phosphorylation
BM525_16315	COG1271	oxidase subunit
BM525_16320	COG1294	oxidase, subunit
BM525_16325	COG1522	sequence-specific DNA binding
BM525_16335	COG1278	Cold shock
BM525_16340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM525_16360	COG0339	signal peptide processing
BM525_16365	COG2201	protein-glutamate methylesterase activity
BM525_16375	COG3852	Histidine kinase
BM525_16385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM525_16390	COG0243	molybdopterin cofactor binding
BM525_16395	COG0823	Involved in the tonB-independent uptake of proteins
BM525_16395	COG4946	Tricorn protease homolog
BM525_16395	COG1506	peptidase
BM525_16440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM525_16450	COG2197	response regulator
BM525_16480	COG1621	beta-fructofuranosidase activity
BM525_16485	COG2814	Major facilitator Superfamily
BM525_16495	COG1629	transport
BM525_16495	COG4206	TonB-dependent receptor
BM525_16505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BM525_16510	COG1278	Cold shock
BM525_16515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM525_16520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM525_16535	COG0281	malic enzyme
BM525_16545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BM525_16575	COG0456	acetyltransferase
BM525_16585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM525_16590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM525_16595	COG2177	Part of the ABC transporter FtsEX involved in
BM525_16600	COG2884	Cell division ATP-binding protein ftsE
BM525_16605	COG0552	protein localization to endoplasmic reticulum
BM525_16610	COG0742	ribosomal rna small subunit methyltransferase
BM525_16620	COG2095	MarC family integral membrane protein
BM525_16640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM525_16645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM525_16650	COG0617	tRNA 3'-terminal CCA addition
BM525_16655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM525_16670	COG0076	glutamate decarboxylase activity
BM525_16685	COG0842	Transport permease protein
BM525_16690	COG1131	(ABC) transporter
BM525_16695	COG0745	RESPONSE REGULATOR receiver
BM525_16700	COG2205	protein histidine kinase activity
BM525_16705	COG4774	siderophore transport
BM525_16730	COG1253	flavin adenine dinucleotide binding
BM525_16740	COG1966	Carbon starvation protein
BM525_16770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM525_16775	COG0049	tRNA binding
BM525_16780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BM525_16785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM525_16790	COG0085	RNA polymerase activity
BM525_16795	COG0222	ribosome binding
BM525_16800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM525_16805	COG0081	regulation of translation
BM525_16810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM525_16830	COG0250	Participates in transcription elongation, termination and antitermination
BM525_16835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM525_16845	COG1132	(ABC) transporter
BM525_16850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BM525_16855	COG3590	peptidase
BM525_16865	COG0513	Belongs to the DEAD box helicase family
BM525_16870	COG0418	dihydroorotase activity
BM525_16875	COG3040	lipid binding
BM525_16880	COG4989	oxidoreductase activity
BM525_16885	COG0346	lactoylglutathione lyase activity
BM525_16890	COG0668	transmembrane transport
BM525_16910	COG0302	gtp cyclohydrolase
BM525_16920	COG2957	Belongs to the agmatine deiminase family
BM525_16925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM525_16935	COG1201	RNA secondary structure unwinding
BM525_16945	COG1793	dna ligase
BM525_16950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM525_16955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM525_16970	COG0625	glutathione transferase activity
BM525_16975	COG0625	glutathione transferase activity
BM525_16985	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BM525_17000	COG1012	belongs to the aldehyde dehydrogenase family
BM525_17005	COG0028	Belongs to the TPP enzyme family
BM525_17015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM525_17020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BM525_17025	COG0330	HflC and HflK could
BM525_17030	COG0330	HflC and HflK could
BM525_17035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM525_17040	COG1923	regulation of RNA biosynthetic process
BM525_17045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM525_17060	COG0802	atpase or kinase
BM525_17065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM525_17065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM525_17070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM525_17080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM525_17090	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BM525_17095	COG0735	belongs to the Fur family
BM525_17105	COG0432	Pfam Uncharacterised protein family UPF0047
BM525_17115	COG0305	Participates in initiation and elongation during chromosome replication
BM525_17140	COG2258	MOSC domain
BM525_17200	COG0784	Response regulator, receiver
BM525_17200	COG2198	Histidine kinase
BM525_17200	COG2205	protein histidine kinase activity
BM525_17210	COG1136	(ABC) transporter
BM525_17210	COG0577	efflux transmembrane transporter activity
BM525_17220	COG0840	transmembrane signaling receptor activity
BM525_17225	COG5002	protein histidine kinase activity
BM525_17230	COG0840	transmembrane signaling receptor activity
BM525_17245	COG2855	membrane
BM525_17250	COG2175	clavaminate synthase activity
BM525_17255	COG0656	L-ascorbic acid biosynthetic process
BM525_17270	COG1501	Belongs to the glycosyl hydrolase 31 family
BM525_17275	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BM525_17280	COG4771	TonB-dependent receptor
BM525_17305	COG1472	Belongs to the glycosyl hydrolase 3 family
BM525_17315	COG2723	6-phospho-beta-galactosidase activity
BM525_17320	COG1609	Transcriptional regulator
BM525_17325	COG0477	Major facilitator Superfamily
BM525_17325	COG2814	Major facilitator Superfamily
BM525_17330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BM525_17335	COG4988	ABC transporter
BM525_17340	COG4890	Cyd operon protein YbgT
BM525_17345	COG1294	oxidase, subunit
BM525_17385	COG4319	ketosteroid isomerase
BM525_17395	COG4771	TonB-dependent receptor
BM525_17410	COG1469	GTP cyclohydrolase I activity
BM525_17425	COG2375	cellular response to nickel ion
BM525_17430	COG3237	CsbD-like
BM525_17445	COG1595	DNA-templated transcription, initiation
BM525_17450	COG1404	Belongs to the peptidase S8 family
BM525_17475	COG0596	Alpha beta hydrolase
BM525_17475	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM525_17495	COG3038	cytochrome b561
BM525_17505	COG1252	NADH dehydrogenase
BM525_17520	COG0583	DNA-binding transcription factor activity
BM525_17525	COG2067	long-chain fatty acid transport protein
BM525_17530	COG2130	NADP-dependent
BM525_17535	COG2203	Gaf domain
BM525_17535	COG5001	Diguanylate cyclase
BM525_17535	COG3706	GGDEF domain
BM525_17535	COG4251	negative regulation of phosphorylation
BM525_17540	COG0784	Response regulator, receiver
BM525_17540	COG2205	protein histidine kinase activity
BM525_17550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BM525_17555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM525_17560	COG1349	DNA-binding transcription factor activity
BM525_17565	COG0673	inositol 2-dehydrogenase activity
BM525_17580	COG0697	spore germination
BM525_17585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BM525_17590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BM525_17595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BM525_17600	COG1166	arginine decarboxylase activity
BM525_17610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM525_17615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM525_17620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM525_17670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BM525_17695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BM525_17705	COG0328	RNA-DNA hybrid ribonuclease activity
BM525_17730	COG3030	protein affecting phage T7 exclusion by the F plasmid
BM525_17735	COG1324	tolerance protein
BM525_17740	COG4232	protein-disulfide reductase activity
BM525_17745	COG0739	heme binding
BM525_17750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM525_17755	COG0511	ligase activity, forming carbon-carbon bonds
BM525_17760	COG0439	Biotin carboxylase
BM525_17800	COG0154	amidase activity
BM525_17815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM525_17820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BM525_17835	COG0151	Belongs to the GarS family
BM525_17855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM525_17860	COG3954	Phosphoribulokinase
BM525_17870	COG0745	RESPONSE REGULATOR receiver
BM525_17885	COG1501	Belongs to the glycosyl hydrolase 31 family
BM525_17965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM525_17975	COG3031	protein transport across the cell outer membrane
BM525_17985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM525_17990	COG1459	type II secretion system
BM525_17995	COG2165	general secretion pathway protein
BM525_18000	COG2165	general secretion pathway protein
BM525_18010	COG4795	General secretion pathway protein
BM525_18025	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BM525_18040	COG1012	belongs to the aldehyde dehydrogenase family
BM525_18050	COG1011	Hydrolase
BM525_18055	COG0494	nUDIX hydrolase
BM525_18060	COG1218	3'(2'),5'-bisphosphate nucleotidase
BM525_18075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BM525_18085	COG3089	Belongs to the UPF0270 family
BM525_18090	COG0429	hydrolase of the alpha beta-hydrolase fold
BM525_18100	COG0488	(ABC) transporter
BM525_18125	COG0545	Peptidyl-prolyl cis-trans isomerase
BM525_18135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BM525_18140	COG2183	response to ionizing radiation
BM525_18160	COG0596	Alpha beta hydrolase
BM525_18165	COG1040	competence protein
BM525_18185	COG1794	racemase activity, acting on amino acids and derivatives
BM525_18200	COG0534	Mate efflux family protein
BM525_18205	COG1649	PFAM Uncharacterised BCR, COG1649
BM525_18205	COG0726	polysaccharide deacetylase
BM525_18215	COG1999	signal sequence binding
BM525_18220	COG0109	protoheme IX farnesyltransferase activity
BM525_18225	COG1612	heme a metabolic process
BM525_18245	COG1845	cytochrome c oxidase, subunit III
BM525_18250	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BM525_18255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM525_18260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BM525_18280	COG0129	dihydroxy-acid dehydratase activity
BM525_18290	COG0606	chelatase, subunit chli
BM525_18295	COG0583	DNA-binding transcription factor activity
BM525_18305	COG2814	Major facilitator Superfamily
BM525_18310	COG1073	alpha beta
BM525_18315	COG0729	surface antigen
BM525_18320	COG2911	Protein conserved in bacteria
BM525_18345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM525_18355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM525_18375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM525_18400	COG1228	amidohydrolase
BM525_18425	COG0425	Belongs to the sulfur carrier protein TusA family
BM525_18440	COG1561	YicC-like family, N-terminal region
BM525_18460	COG2723	6-phospho-beta-galactosidase activity
BM525_18465	COG2211	Major facilitator Superfamily
BM525_18470	COG1609	Transcriptional regulator
BM525_18485	COG2199	diguanylate cyclase activity
BM525_18485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BM525_18510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM525_18530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM525_18535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM525_18555	COG1475	DNA binding
BM525_18560	COG1192	Involved in chromosome partitioning
BM525_18585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM525_18590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM525_18600	COG0706	membrane insertase activity
BM525_18605	COG0594	ribonuclease P activity
BM525_18635	COG0551	DNA topoisomerase type I activity
BM525_18635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM525_18755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM525_18850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BM525_19355	COG2813	Specifically methylates the guanine in position
BM525_19445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM525_19445	COG2755	lipolytic protein G-D-S-L family
BM525_19855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BM525_19860	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BM525_19960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM525_20015	COG4232	protein-disulfide reductase activity
BM525_20065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BM525_20095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM525_20115	COG1104	cysteine desulfurase activity
BM525_20120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BM525_20145	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BM525_20180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM525_20190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BM525_20245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM525_20295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM525_20320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM525_20335	COG0587	DNA-directed DNA polymerase activity
BM525_20365	COG3706	GGDEF domain
BM525_20410	COG0629	single-stranded DNA binding
BM525_20440	COG0776	regulation of translation
BM525_20675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM525_20680	COG1061	Type III restriction enzyme res subunit
BM525_20685	COG1002	Type II restriction enzyme, methylase subunits
BM525_20695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BM525_20740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM525_20780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM525_20780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM525_20825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BM525_20850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM525_20850	COG0475	glutathione-regulated potassium exporter activity
BM525_20900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM525_20905	COG0557	exoribonuclease II activity
BM525_20945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM525_20965	COG0497	DNA recombination
BM525_21140	COG1404	Belongs to the peptidase S8 family
BM525_21215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM525_21220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BM525_21225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BM525_21240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BM525_21245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BM525_21255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM525_21305	COG1596	polysaccharide export
BM525_21315	COG2204	response regulator
BM525_21320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM525_21320	COG4191	Histidine kinase
BM525_21330	COG0367	asparagine synthase
BM525_21340	COG1192	Involved in chromosome partitioning
BM525_21345	COG1475	DNA binding
BM525_21360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM525_21365	COG0489	protein tyrosine kinase activity
BM525_21375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM525_21390	COG0463	Glycosyl transferase, family 2
BM525_21395	COG0367	asparagine synthase
BM525_21405	COG2244	polysaccharide biosynthetic process
BM525_21415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM525_21440	COG2925	Exonuclease
BM525_21500	COG3706	GGDEF domain
BM525_21525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM525_21600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BM525_21655	COG4251	negative regulation of phosphorylation
BM525_21655	COG3706	GGDEF domain
BM525_21655	COG2203	Gaf domain
BM525_21655	COG5001	Diguanylate cyclase
BM525_21725	COG0587	DNA-directed DNA polymerase activity