locus-tag	class	description
MADE_000001020785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MADE_000001020790	COG0358	DNA primase activity
MADE_000001020805	COG0723	plastoquinol--plastocyanin reductase activity
MADE_000001020810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MADE_000001020840	COG0024	Methionine aminopeptidase
MADE_000001020845	COG0528	UMP kinase activity
MADE_000001020915	COG0811	peptide transport
MADE_000001020920	COG1846	Transcriptional regulator
MADE_000001020935	COG1024	Enoyl-CoA hydratase
MADE_000001020935	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_000001020955	COG1025	Belongs to the peptidase M16 family
MADE_000001020960	COG2062	phosphohistidine phosphatase, SixA
MADE_000001020975	COG4137	Cytochrome C assembly protein
MADE_000001020980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MADE_000001021035	COG1132	(ABC) transporter
MADE_000001021050	COG0228	four-way junction DNA binding
MADE_000001021055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MADE_000001021060	COG0336	Belongs to the RNA methyltransferase TrmD family
MADE_000001021065	COG0335	large ribosomal subunit rRNA binding
MADE_000001021070	COG2860	membrane
MADE_000001021080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MADE_000001021085	COG1605	Chorismate mutase
MADE_000001021085	COG0287	Prephenate dehydrogenase
MADE_000001021090	COG0077	Prephenate dehydratase
MADE_000001021090	COG1605	Chorismate mutase
MADE_000001021100	COG0023	Translation Initiation Factor
MADE_000001021130	COG2205	protein histidine kinase activity
MADE_000001021140	COG2204	response regulator
MADE_000001021160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MADE_000001021165	COG0494	nUDIX hydrolase
MADE_000001021170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MADE_000001021180	COG2255	four-way junction helicase activity
MADE_000001021190	COG0824	Thioesterase
MADE_000001021195	COG0811	peptide transport
MADE_000001021210	COG0823	Involved in the tonB-independent uptake of proteins
MADE_000001021230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MADE_000001021245	COG4667	esterase of the alpha-beta hydrolase superfamily
MADE_000001021250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MADE_000001021260	COG2205	protein histidine kinase activity
MADE_000001021260	COG0784	Response regulator, receiver
MADE_000001021280	COG3038	cytochrome b561
MADE_000001021300	COG0583	DNA-binding transcription factor activity
MADE_000001021305	COG1451	nucleotide metabolic process
MADE_000001021315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_000001021325	COG1309	transcriptional regulator
MADE_000001021330	COG4774	siderophore transport
MADE_000001021350	COG3706	GGDEF domain
MADE_000001021360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MADE_000001021360	COG3008	intermembrane lipid transfer
MADE_000001021365	COG2995	paraquat-inducible protein a
MADE_000001021380	COG0017	Asparaginyl-tRNA synthetase
MADE_000001021450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_000001021550	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MADE_000001021560	COG4591	ABC-type transport system involved in lipoprotein release permease component
MADE_000001021575	COG3724	N-succinylarginine dihydrolase activity
MADE_000001021585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MADE_000001021610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_000001021620	COG4771	TonB-dependent receptor
MADE_000001021640	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_000001021680	COG2850	peptidyl-arginine hydroxylation
MADE_000001021690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MADE_000001021695	COG2915	High frequency lysogenization protein hflD homolog
MADE_000001021700	COG0482	sulfurtransferase activity
MADE_000001021705	COG1187	pseudouridine synthase activity
MADE_000001021720	COG1278	Cold shock
MADE_000001021725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MADE_000001021735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MADE_000001021740	COG0492	ferredoxin-NADP+ reductase activity
MADE_000001021745	COG3092	negative regulation of chromosome organization
MADE_000001021750	COG3091	SprT-like family
MADE_000001021755	COG0616	signal peptide processing
MADE_000001021770	COG0778	Nitroreductase
MADE_000001021780	COG0252	asparaginase activity
MADE_000001021785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MADE_000001021790	COG0321	lipoyl(octanoyl) transferase activity
MADE_000001021795	COG2921	Belongs to the UPF0250 family
MADE_000001021800	COG1686	Belongs to the peptidase S11 family
MADE_000001021805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MADE_000001021810	COG0772	Belongs to the SEDS family
MADE_000001021815	COG0768	penicillin binding
MADE_000001021820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MADE_000001021825	COG0799	negative regulation of ribosome biogenesis
MADE_000001021835	COG1466	dna polymerase III delta subunit
MADE_000001021840	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MADE_000001021845	COG0495	leucyl-tRNA aminoacylation
MADE_000001021855	COG1067	ATP-dependent peptidase activity
MADE_000001021860	COG0596	Alpha beta hydrolase
MADE_000001021865	COG3706	GGDEF domain
MADE_000001021875	COG1534	Rna-binding protein
MADE_000001021885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MADE_000001021895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MADE_000001021900	COG0149	triose-phosphate isomerase activity
MADE_000001021905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MADE_000001021915	COG3300	MHYT domain
MADE_000001021915	COG5001	Diguanylate cyclase
MADE_000001021935	COG1803	Methylglyoxal synthase
MADE_000001021935	COG1597	lipid kinase activity
MADE_000001021945	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_000001021950	COG0561	phosphatase activity
MADE_000001021965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_000001022000	COG1132	(ABC) transporter
MADE_000001022025	COG3130	regulation of translation
MADE_000001022030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MADE_000001022075	COG2197	response regulator
MADE_000001022080	COG0670	Belongs to the BI1 family
MADE_000001022110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MADE_000001022115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MADE_000001022120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MADE_000001022135	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_000001022145	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_000001022230	COG0140	phosphoribosyl-ATP diphosphatase activity
MADE_000001022230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MADE_000001022250	COG1183	phosphatidylcholine synthase activity
MADE_000001022270	COG0277	FAD linked oxidase domain protein
MADE_000001022275	COG0542	response to heat
MADE_000001022280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MADE_000001022295	COG3344	reverse transcriptase
MADE_000001022305	COG0343	queuine tRNA-ribosyltransferase activity
MADE_000001022345	COG2244	polysaccharide biosynthetic process
MADE_000001022360	COG3344	reverse transcriptase
MADE_000001022365	COG1435	thymidine kinase activity
MADE_000001022375	COG1609	Transcriptional regulator
MADE_000001022380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MADE_000001022410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MADE_000001022415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MADE_000001022420	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_000001022420	COG1024	Enoyl-CoA hydratase
MADE_000001022435	COG1012	belongs to the aldehyde dehydrogenase family
MADE_000001022455	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MADE_000001022490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_000001022595	COG0237	dephospho-CoA kinase activity
MADE_000001022595	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MADE_000001022605	COG0849	cell division
MADE_000001022610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MADE_000001022640	COG0069	glutamate synthase activity
MADE_000001022640	COG0070	glutamate synthase
MADE_000001022640	COG0067	glutamate synthase
MADE_000001022665	COG4771	TonB-dependent receptor
MADE_000001022745	COG0848	biopolymer transport protein
MADE_000001022760	COG0457	Tetratricopeptide repeat
MADE_000001022765	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MADE_000001022775	COG1215	transferase activity, transferring glycosyl groups
MADE_000001022790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MADE_000001022795	COG0702	epimerase
MADE_000001022810	COG5002	protein histidine kinase activity
MADE_000001022810	COG5001	Diguanylate cyclase
MADE_000001022820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MADE_000001022830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_000001022840	COG0583	DNA-binding transcription factor activity
MADE_000001022845	COG0121	glutamine amidotransferase
MADE_000001022850	COG4682	membrane
MADE_000001022870	COG1953	Uracil, thiamine, allantoin
MADE_000001022875	COG4771	TonB-dependent receptor
MADE_000001022885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MADE_000001022890	COG0778	Nitroreductase
MADE_000001022895	COG0596	Alpha beta hydrolase
MADE_000001022900	COG0251	oxidation-reduction process
MADE_000001022905	COG1335	isochorismatase
MADE_000001022910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MADE_000001022915	COG1309	transcriptional regulator
MADE_000001022930	COG4628	conserved protein (DUF2132)
MADE_000001022935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_000001022945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MADE_000001022955	COG1477	protein flavinylation
MADE_000001022960	COG2871	sodium ion transport
MADE_000001022965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_000001022970	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_000001022975	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_000001022980	COG1805	sodium ion transport
MADE_000001022985	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MADE_000001022990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MADE_000001022995	COG0545	Peptidyl-prolyl cis-trans isomerase
MADE_000001023000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MADE_000001023005	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MADE_000001023020	COG0039	L-malate dehydrogenase activity
MADE_000001023025	COG1438	arginine binding
MADE_000001023050	COG0572	uridine kinase
MADE_000001023055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MADE_000001023075	COG0745	RESPONSE REGULATOR receiver
MADE_000001023075	COG3706	GGDEF domain
MADE_000001023080	COG2176	DNA-directed DNA polymerase activity
MADE_000001023090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_000001023100	COG2205	protein histidine kinase activity
MADE_000001023110	COG0189	ligase activity
MADE_000001023120	COG0189	ligase activity
MADE_000001023120	COG4067	protein conserved in archaea
MADE_000001023145	COG1283	sodium-dependent phosphate transmembrane transporter activity
MADE_000001023150	COG0667	Aldo Keto reductase
MADE_000001023170	COG5001	Diguanylate cyclase
MADE_000001023230	COG2274	protein secretion by the type I secretion system
MADE_000001023235	COG0583	DNA-binding transcription factor activity
MADE_000001023285	COG0049	tRNA binding
MADE_000001023290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MADE_000001023295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MADE_000001023300	COG0085	RNA polymerase activity
MADE_000001023310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MADE_000001023315	COG0081	regulation of translation
MADE_000001023320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MADE_000001023340	COG0250	Participates in transcription elongation, termination and antitermination
MADE_000001023345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MADE_000001023355	COG1132	(ABC) transporter
MADE_000001023360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MADE_000001023365	COG3590	peptidase
MADE_000001023375	COG0513	Belongs to the DEAD box helicase family
MADE_000001023380	COG0418	dihydroorotase activity
MADE_000001023385	COG3040	lipid binding
MADE_000001023390	COG4989	oxidoreductase activity
MADE_000001023395	COG0346	lactoylglutathione lyase activity
MADE_000001023400	COG0668	transmembrane transport
MADE_000001023420	COG0302	gtp cyclohydrolase
MADE_000001023430	COG2957	Belongs to the agmatine deiminase family
MADE_000001023435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_000001023445	COG1201	RNA secondary structure unwinding
MADE_000001023455	COG1793	dna ligase
MADE_000001023460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MADE_000001023465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_000001023475	COG0646	methionine synthase
MADE_000001023475	COG1410	methionine synthase
MADE_000001023480	COG0625	glutathione transferase activity
MADE_000001023485	COG0625	glutathione transferase activity
MADE_000001023495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MADE_000001023510	COG1012	belongs to the aldehyde dehydrogenase family
MADE_000001023515	COG0028	Belongs to the TPP enzyme family
MADE_000001023525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MADE_000001023530	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MADE_000001023535	COG0330	HflC and HflK could
MADE_000001023540	COG0330	HflC and HflK could
MADE_000001023545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MADE_000001023550	COG1923	regulation of RNA biosynthetic process
MADE_000001023555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MADE_000001023570	COG0802	atpase or kinase
MADE_000001023575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MADE_000001023575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MADE_000001023580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MADE_000001023590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MADE_000001023600	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MADE_000001023605	COG0735	belongs to the Fur family
MADE_000001023615	COG0432	Pfam Uncharacterised protein family UPF0047
MADE_000001023625	COG0305	Participates in initiation and elongation during chromosome replication
MADE_000001023640	COG2832	Protein of unknown function (DUF454)
MADE_000001023650	COG2223	nitrite transmembrane transporter activity
MADE_000001023700	COG0606	chelatase, subunit chli
MADE_000001023710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MADE_1000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MADE_1000025	COG0187	DNA topoisomerase II activity
MADE_1000045	COG2818	Glycosylase
MADE_1000055	COG3078	GTPase activator activity
MADE_1000075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MADE_1000075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MADE_1000080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MADE_1000085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MADE_1000090	COG0569	domain protein
MADE_1000095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MADE_1000095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MADE_1000100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_1000115	COG0758	DNA mediated transformation
MADE_1000130	COG0009	L-threonylcarbamoyladenylate synthase
MADE_1000135	COG0408	coproporphyrinogen oxidase activity
MADE_1000140	COG3047	cAMP biosynthetic process
MADE_1000155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MADE_1000165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MADE_1000215	COG2234	aminopeptidase activity
MADE_1000220	COG0463	Glycosyl transferase, family 2
MADE_1000230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MADE_1000260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_1000290	COG3642	lipopolysaccharide core region biosynthetic process
MADE_1000295	COG0859	PFAM glycosyl transferase family 9
MADE_1000325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_1000340	COG3161	chorismate lyase activity
MADE_1000345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MADE_1000365	COG0210	DNA helicase
MADE_1000410	COG1959	2 iron, 2 sulfur cluster binding
MADE_1000415	COG0730	response to heat
MADE_1000430	COG4771	TonB-dependent receptor
MADE_1000445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MADE_1000450	COG4988	ABC transporter
MADE_1000460	COG1271	oxidase subunit
MADE_1000465	COG0425	Belongs to the sulfur carrier protein TusA family
MADE_1000465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_1000475	COG0450	alkyl hydroperoxide reductase
MADE_1000485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MADE_1000515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_1000565	COG1196	nuclear chromosome segregation
MADE_1000630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1000635	COG0842	Transport permease protein
MADE_1000635	COG1129	ABC transporter
MADE_1000640	COG1129	ABC transporter
MADE_1000640	COG0842	Transport permease protein
MADE_1000645	COG0842	Transport permease protein
MADE_1000660	COG1960	acyl-CoA dehydrogenase activity
MADE_1000665	COG0583	DNA-binding transcription factor activity
MADE_1000675	COG3106	COG3106 Predicted ATPase
MADE_1000695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MADE_1000715	COG0352	thiamine-phosphate diphosphorylase activity
MADE_1000725	COG3071	HemY protein
MADE_1000730	COG2959	enzyme of heme biosynthesis
MADE_1000740	COG0181	hydroxymethylbilane synthase activity
MADE_1000760	COG0194	GDP metabolic process
MADE_1000770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MADE_1000780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MADE_1000785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MADE_1000795	COG0678	peroxiredoxin activity
MADE_1000810	COG1178	ABC-type Fe3 transport system permease component
MADE_1000815	COG3842	ATPase activity
MADE_1000820	COG0668	transmembrane transport
MADE_1000825	COG2081	HI0933 family
MADE_1000865	COG2200	EAL domain
MADE_1000870	COG0583	DNA-binding transcription factor activity
MADE_1000880	COG2076	Multidrug Resistance protein
MADE_1000895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1000910	COG0427	acetyl-CoA hydrolase
MADE_1000915	COG0123	including yeast histone deacetylase and acetoin utilization protein
MADE_1000930	COG0840	transmembrane signaling receptor activity
MADE_1000940	COG3064	Membrane
MADE_1000950	COG5002	protein histidine kinase activity
MADE_1000950	COG5001	Diguanylate cyclase
MADE_1000965	COG0514	ATP-dependent DNA helicase (RecQ)
MADE_1000970	COG2239	Acts as a magnesium transporter
MADE_1000975	COG2962	Rard protein
MADE_1000980	COG0745	RESPONSE REGULATOR receiver
MADE_1000980	COG3706	GGDEF domain
MADE_1000985	COG0210	DNA helicase
MADE_1000995	COG1011	Hydrolase
MADE_1001010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MADE_1001015	COG0019	diaminopimelate decarboxylase activity
MADE_1001045	COG0163	prenyltransferase activity
MADE_1001050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MADE_1001065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MADE_1001085	COG1077	Cell shape determining protein MreB Mrl
MADE_1001095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MADE_1001100	COG2814	Major facilitator Superfamily
MADE_1001105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_1001135	COG1085	galactose-1-phosphate uridylyltransferase
MADE_1001140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MADE_1001150	COG0629	single-stranded DNA binding
MADE_1001165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MADE_1001170	COG3250	beta-galactosidase activity
MADE_1001190	COG1349	DNA-binding transcription factor activity
MADE_1001235	COG3409	Peptidoglycan-binding domain 1 protein
MADE_1001235	COG3267	Type II secretory pathway component ExeA
MADE_1001245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MADE_1001250	COG1459	type II secretion system
MADE_1001295	COG1077	Cell shape determining protein MreB Mrl
MADE_1001300	COG1792	Involved in formation and maintenance of cell shape
MADE_1001305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MADE_1001315	COG1530	ribonuclease E activity
MADE_1001325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_1001330	COG0312	modulator of DNA gyrase
MADE_1001335	COG3028	Belongs to the UPF0307 family
MADE_1001340	COG0312	modulator of DNA gyrase
MADE_1001355	COG0745	RESPONSE REGULATOR receiver
MADE_1001360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_1001360	COG4191	Histidine kinase
MADE_1001365	COG0297	glycogen (starch) synthase activity
MADE_1001375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MADE_1001380	COG0596	Alpha beta hydrolase
MADE_1001445	COG4974	Belongs to the 'phage' integrase family
MADE_1001465	COG0758	DNA mediated transformation
MADE_1001525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_1001530	COG5002	protein histidine kinase activity
MADE_1001535	COG0745	RESPONSE REGULATOR receiver
MADE_1001555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_1001660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MADE_1001675	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MADE_1001690	COG0375	protein maturation
MADE_1001700	COG0409	Hydrogenase expression formation protein
MADE_1001710	COG0309	Hydrogenase expression formation protein (HypE)
MADE_1001715	COG0789	Transcriptional regulator
MADE_1001720	COG2217	Heavy metal translocating P-type atpase
MADE_1001830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MADE_1001845	COG4372	Transposase
MADE_1001855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MADE_1001865	COG0463	Glycosyl transferase, family 2
MADE_1001870	COG0745	RESPONSE REGULATOR receiver
MADE_1001875	COG5002	protein histidine kinase activity
MADE_1001905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MADE_1001915	COG0789	Transcriptional regulator
MADE_1001920	COG2217	Heavy metal translocating P-type atpase
MADE_1001960	COG0531	amino acid
MADE_1001970	COG2132	Multicopper oxidase
MADE_1002000	COG0745	RESPONSE REGULATOR receiver
MADE_1002010	COG0835	chemotaxis
MADE_1002015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MADE_1002060	COG0546	phosphoglycolate phosphatase activity
MADE_1002085	COG1609	Transcriptional regulator
MADE_1002090	COG0673	inositol 2-dehydrogenase activity
MADE_1002100	COG2211	Major facilitator Superfamily
MADE_1002105	COG1082	Xylose isomerase domain protein TIM barrel
MADE_1002125	COG1454	alcohol dehydrogenase
MADE_1002270	COG0089	rRNA binding
MADE_1002280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MADE_1002290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MADE_1002305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MADE_1002320	COG3344	reverse transcriptase
MADE_1002325	COG0438	transferase activity, transferring glycosyl groups
MADE_1002335	COG1519	Transferase
MADE_1002355	COG0840	transmembrane signaling receptor activity
MADE_1002370	COG0788	formyltetrahydrofolate deformylase activity
MADE_1002380	COG1643	Atp-dependent helicase
MADE_1002385	COG2951	lytic endotransglycosylase activity
MADE_1002390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MADE_1002405	COG2354	Protein conserved in bacteria
MADE_1002410	COG4977	sequence-specific DNA binding
MADE_1002425	COG0004	ammonium transporteR
MADE_1002430	COG0405	Gamma-glutamyltransferase
MADE_1002435	COG2837	iron assimilation
MADE_1002450	COG0540	Belongs to the ATCase OTCase family
MADE_1002475	COG2205	protein histidine kinase activity
MADE_1002475	COG5002	protein histidine kinase activity
MADE_1002475	COG0784	Response regulator, receiver
MADE_1002490	COG3300	MHYT domain
MADE_1002490	COG5001	Diguanylate cyclase
MADE_1002500	COG1012	belongs to the aldehyde dehydrogenase family
MADE_1002510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MADE_1002525	COG0180	Tryptophanyl-tRNA synthetase
MADE_1002530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MADE_1002550	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MADE_1002560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MADE_1002595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MADE_1002600	COG0281	malic enzyme
MADE_1002610	COG0625	glutathione transferase activity
MADE_1002620	COG0753	catalase activity
MADE_1002640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MADE_1002640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MADE_1002650	COG0137	argininosuccinate synthase activity
MADE_1002670	COG1803	Methylglyoxal synthase
MADE_1002680	COG0745	RESPONSE REGULATOR receiver
MADE_1002685	COG2205	protein histidine kinase activity
MADE_1002690	COG2267	carboxylic ester hydrolase activity
MADE_1002695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MADE_1002705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MADE_1002715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MADE_1002720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_1002725	COG4942	peptidase
MADE_1002730	COG2861	carbohydrate metabolic process
MADE_1002755	COG1162	GTPase activity
MADE_1002760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MADE_1002790	COG0028	Belongs to the TPP enzyme family
MADE_1002815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MADE_1002820	COG0805	protein transport
MADE_1002830	COG0084	hydrolase, TatD family'
MADE_1002835	COG5001	Diguanylate cyclase
MADE_1002835	COG4251	negative regulation of phosphorylation
MADE_1002835	COG3706	GGDEF domain
MADE_1002835	COG2203	Gaf domain
MADE_1002845	COG0248	Ppx GppA phosphatase
MADE_1002850	COG0513	Belongs to the DEAD box helicase family
MADE_1002855	COG3118	belongs to the thioredoxin family
MADE_1002860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MADE_1002870	COG5002	protein histidine kinase activity
MADE_1002870	COG0784	Response regulator, receiver
MADE_1002875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MADE_1002885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MADE_1002895	COG0783	Belongs to the Dps family
MADE_1002900	COG2133	pyrroloquinoline quinone binding
MADE_1002905	COG1506	peptidase
MADE_1002905	COG0823	Involved in the tonB-independent uptake of proteins
MADE_1002905	COG4946	Tricorn protease homolog
MADE_1002915	COG3118	belongs to the thioredoxin family
MADE_1002930	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MADE_1002940	COG1012	belongs to the aldehyde dehydrogenase family
MADE_1002960	COG1757	Na H antiporter
MADE_1002975	COG3876	Protein conserved in bacteria
MADE_1002980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MADE_1002990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MADE_1003025	COG2824	Alkylphosphonate utilization operon protein PhnA
MADE_1003030	COG0454	-acetyltransferase
MADE_1003060	COG3093	addiction module antidote protein HigA
MADE_1003075	COG2026	Addiction module toxin, RelE StbE family
MADE_1003165	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1003240	COG2801	Transposase and inactivated derivatives
MADE_1003265	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1003305	COG0183	Belongs to the thiolase family
MADE_1003310	COG1250	3-hydroxyacyl-CoA dehydrogenase
MADE_1003310	COG1024	Enoyl-CoA hydratase
MADE_1003320	COG0006	proline dipeptidase activity
MADE_1003330	COG0142	geranyltranstransferase activity
MADE_1003360	COG4942	peptidase
MADE_1003360	COG1388	LysM domain
MADE_1003365	COG1238	metal cluster binding
MADE_1003375	COG0585	pseudouridine synthase activity
MADE_1003380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MADE_1003390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MADE_1003400	COG0840	transmembrane signaling receptor activity
MADE_1003440	COG0494	nUDIX hydrolase
MADE_1003445	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
MADE_1003450	COG0730	response to heat
MADE_1003455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MADE_1003460	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MADE_1003470	COG3706	GGDEF domain
MADE_1003470	COG0745	RESPONSE REGULATOR receiver
MADE_1003495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MADE_1003510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MADE_1003520	COG1648	precorrin-2 dehydrogenase activity
MADE_1003520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MADE_1003525	COG0513	Belongs to the DEAD box helicase family
MADE_1003545	COG1538	Outer membrane efflux protein
MADE_1003550	COG0494	nUDIX hydrolase
MADE_1003560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MADE_1003565	COG3150	esterase
MADE_1003570	COG0187	DNA topoisomerase II activity
MADE_1003580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MADE_1003605	COG1509	lysine 2,3-aminomutase activity
MADE_1003615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MADE_1003630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MADE_1003645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MADE_1003660	COG0271	Belongs to the BolA IbaG family
MADE_1003675	COG3707	response regulator
MADE_1003690	COG0659	secondary active sulfate transmembrane transporter activity
MADE_1003695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MADE_1003705	COG0243	molybdopterin cofactor binding
MADE_1003710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MADE_1003710	COG1648	precorrin-2 dehydrogenase activity
MADE_1003715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MADE_1003725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MADE_1003725	COG1116	anion transmembrane transporter activity
MADE_1003735	COG1116	anion transmembrane transporter activity
MADE_1003750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MADE_1003755	COG4206	TonB-dependent receptor
MADE_1003795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MADE_1003800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MADE_1003815	COG0537	adenosine 5'-monophosphoramidase activity
MADE_1003830	COG3135	benzoate transporter
MADE_1003835	COG1396	sequence-specific DNA binding
MADE_1003840	COG2974	May be involved in recombination
MADE_1003845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_1003845	COG4191	Histidine kinase
MADE_1003850	COG0745	RESPONSE REGULATOR receiver
MADE_1003855	COG5002	protein histidine kinase activity
MADE_1003880	COG0811	peptide transport
MADE_1003885	COG0811	peptide transport
MADE_1003890	COG0848	biopolymer transport protein
MADE_1003895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MADE_1003905	COG3437	response regulator, receiver
MADE_1003915	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_1003925	COG2133	pyrroloquinoline quinone binding
MADE_1003935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_1003960	COG0527	aspartate kinase activity
MADE_1003965	COG0840	transmembrane signaling receptor activity
MADE_1003970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MADE_1003975	COG2967	ApaG domain
MADE_1003985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MADE_1003990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_1003995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MADE_1004000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MADE_1004010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MADE_1004030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MADE_1004045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MADE_1004050	COG3956	TIGRFAM MazG family protein
MADE_1004075	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1004085	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_1004095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MADE_1004105	COG0463	Glycosyl transferase, family 2
MADE_1004130	COG0745	RESPONSE REGULATOR receiver
MADE_1004140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MADE_1004145	COG2857	Cytochrome c1
MADE_1004150	COG0625	glutathione transferase activity
MADE_1004155	COG2969	positive regulation of protein catabolic process
MADE_1004160	COG2239	Acts as a magnesium transporter
MADE_1004165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MADE_1004175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MADE_1004185	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MADE_1004190	COG1137	ATPase activity
MADE_1004195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MADE_1004205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MADE_1004220	COG1127	ABC transporter
MADE_1004225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MADE_1004230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MADE_1004235	COG2854	intermembrane phospholipid transfer
MADE_1004245	COG5007	Belongs to the BolA IbaG family
MADE_1004255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MADE_1004260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MADE_1004270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MADE_1004295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_1004305	COG4771	TonB-dependent receptor
MADE_1004310	COG0697	spore germination
MADE_1004320	COG2205	protein histidine kinase activity
MADE_1004320	COG0784	Response regulator, receiver
MADE_1004345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MADE_1004355	COG0126	phosphoglycerate kinase activity
MADE_1004360	COG3588	fructose-bisphosphate aldolase
MADE_1004370	COG4946	Tricorn protease homolog
MADE_1004370	COG1506	peptidase
MADE_1004370	COG0823	Involved in the tonB-independent uptake of proteins
MADE_1004375	COG0248	Ppx GppA phosphatase
MADE_1004380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MADE_1004390	COG0573	inorganic phosphate transmembrane transporter activity
MADE_1004400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MADE_1004410	COG0306	phosphate transporter
MADE_1004420	COG0583	DNA-binding transcription factor activity
MADE_1004430	COG1272	protein, Hemolysin III
MADE_1004435	COG1846	Transcriptional regulator
MADE_1004440	COG1764	response to oxidative stress
MADE_1004455	COG1739	Uncharacterized protein family UPF0029
MADE_1004465	COG0420	3'-5' exonuclease activity
MADE_1004470	COG0419	ATPase involved in DNA repair
MADE_1004485	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MADE_1004510	COG2986	histidine ammonia-lyase
MADE_1004540	COG0488	(ABC) transporter
MADE_1004565	COG0668	transmembrane transport
MADE_1004625	COG1346	cytolysis
MADE_1004655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MADE_1004665	COG0513	Belongs to the DEAD box helicase family
MADE_1004675	COG3267	Type II secretory pathway component ExeA
MADE_1004675	COG3409	Peptidoglycan-binding domain 1 protein
MADE_1004690	COG0066	3-isopropylmalate dehydratase activity
MADE_1004700	COG0473	3-isopropylmalate dehydrogenase activity
MADE_1004705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MADE_1004725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MADE_1004740	COG4555	ABC transporter
MADE_1004745	COG1668	transmembrane transport
MADE_1004765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_1004770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_1004775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MADE_1004785	COG1138	Cytochrome C-type biogenesis protein
MADE_1004790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MADE_1004805	COG2853	Lipoprotein
MADE_1004810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MADE_1004820	COG3104	oligopeptide transport
MADE_1004850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MADE_1004865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MADE_1004870	COG1555	photosystem II stabilization
MADE_1004870	COG1596	polysaccharide export
MADE_1004875	COG0473	3-isopropylmalate dehydrogenase activity
MADE_1004890	COG1611	Belongs to the LOG family
MADE_1004895	COG3706	GGDEF domain
MADE_1004895	COG0745	RESPONSE REGULATOR receiver
MADE_1004900	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MADE_1004900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MADE_1005225	COG2976	Protein conserved in bacteria
MADE_1005230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_1005250	COG1570	exodeoxyribonuclease VII activity
MADE_1005255	COG0516	GMP reductase activity
MADE_1005255	COG0517	IMP dehydrogenase activity
MADE_1005290	COG1234	tRNA 3'-trailer cleavage
MADE_1005300	COG1720	tRNA m6t6A37 methyltransferase activity
MADE_1005340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MADE_1005345	COG0575	Belongs to the CDS family
MADE_1005370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MADE_1005390	COG0587	DNA-directed DNA polymerase activity
MADE_1005395	COG0825	malonyl-CoA metabolic process
MADE_1005400	COG0037	tRNA processing
MADE_1005420	COG0590	tRNA wobble adenosine to inosine editing
MADE_1005435	COG0047	phosphoribosylformylglycinamidine synthase activity
MADE_1005435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MADE_1005445	COG2840	Smr protein MutS2
MADE_1005490	COG1132	(ABC) transporter
MADE_1005555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MADE_1005560	COG0789	Transcriptional regulator
MADE_1005585	COG0789	Transcriptional regulator
MADE_1005625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MADE_1005635	COG4644	lycopene metabolic process
MADE_1005650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1005655	COG2197	response regulator
MADE_1005695	COG0835	chemotaxis
MADE_1005695	COG0784	Response regulator, receiver
MADE_1005700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MADE_1005705	COG1815	bacterial-type flagellum-dependent cell motility
MADE_1005710	COG1558	bacterial-type flagellum-dependent cell motility
MADE_1005715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MADE_1005720	COG1749	Flagellar hook protein flgE
MADE_1005725	COG4787	bacterial-type flagellum-dependent cell motility
MADE_1005730	COG4786	Flagellar basal body rod
MADE_1005745	COG3951	Flagellar rod assembly protein muramidase FlgJ
MADE_1005745	COG1705	Flagellar rod assembly protein muramidase FlgJ
MADE_1005785	COG1516	flagellar protein fliS
MADE_1005820	COG2089	acid synthase
MADE_1005840	COG2963	transposase activity
MADE_1005860	COG1083	cytidylyl-transferase
MADE_1005865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MADE_1005870	COG1086	Polysaccharide biosynthesis protein
MADE_1005880	COG2204	response regulator
MADE_1005885	COG3852	Histidine kinase
MADE_1005890	COG2204	response regulator
MADE_1005895	COG1677	Flagellar hook-basal body complex protein FliE
MADE_1005900	COG1766	The M ring may be actively involved in energy transduction
MADE_1005905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MADE_1005955	COG1987	bacterial-type flagellum assembly
MADE_1005970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MADE_1005980	COG0455	bacterial-type flagellum organization
MADE_1005995	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MADE_1006000	COG2198	Histidine kinase
MADE_1006000	COG0643	Histidine kinase
MADE_1006010	COG1192	Involved in chromosome partitioning
MADE_1006020	COG0835	chemotaxis
MADE_1006035	COG1410	methionine synthase
MADE_1006035	COG0646	methionine synthase
MADE_1006040	COG0646	methionine synthase
MADE_1006040	COG1410	methionine synthase
MADE_1006050	COG3123	guanosine phosphorylase activity
MADE_1006055	COG0583	DNA-binding transcription factor activity
MADE_1006060	COG0583	DNA-binding transcription factor activity
MADE_1006070	COG0659	secondary active sulfate transmembrane transporter activity
MADE_1006085	COG3590	peptidase
MADE_1006095	COG2137	regulation of response to DNA damage stimulus
MADE_1006100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MADE_1006120	COG5016	pyruvate
MADE_1006120	COG0511	ligase activity, forming carbon-carbon bonds
MADE_1006125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MADE_1006130	COG4172	Belongs to the ABC transporter superfamily
MADE_1006140	COG4171	peptide transport system, permease
MADE_1006145	COG4168	peptide transport system, permease
MADE_1006150	COG0747	negative chemotaxis
MADE_1006155	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MADE_1006160	COG1842	Phage shock protein A
MADE_1006190	COG0625	glutathione transferase activity
MADE_1006195	COG1522	sequence-specific DNA binding
MADE_1006260	COG0811	peptide transport
MADE_1006265	COG0848	biopolymer transport protein
MADE_1006285	COG1444	tRNA N-acetyltransferase activity
MADE_1006320	COG0456	acetyltransferase
MADE_1006335	COG0583	DNA-binding transcription factor activity
MADE_1006350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MADE_1006355	COG0656	L-ascorbic acid biosynthetic process
MADE_1006395	COG3344	reverse transcriptase
MADE_1006415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MADE_1006425	COG3706	GGDEF domain
MADE_1006455	COG0543	2 iron, 2 sulfur cluster binding
MADE_1006455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MADE_1006470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MADE_1006475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MADE_1006480	COG0564	pseudouridine synthase activity
MADE_1006490	COG0612	Peptidase, M16
MADE_1006495	COG2918	glutathione biosynthetic process
MADE_1006520	COG2840	Smr protein MutS2
MADE_1006525	COG2890	protein-(glutamine-N5) methyltransferase activity
MADE_1006540	COG2719	SpoVR family
MADE_1006545	COG2718	Belongs to the UPF0229 family
MADE_1006550	COG2766	serine protein kinase
MADE_1006560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MADE_1006565	COG4771	TonB-dependent receptor
MADE_1006590	COG0450	alkyl hydroperoxide reductase
MADE_1006595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_1006600	COG2885	chlorophyll binding
MADE_1006605	COG0584	glycerophosphoryl diester phosphodiesterase
MADE_1006610	COG0346	lactoylglutathione lyase activity
MADE_1006615	COG1278	Cold shock
MADE_1006630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MADE_1006635	COG4660	Part of a membrane complex involved in electron transport
MADE_1006640	COG4659	FMN binding
MADE_1006645	COG4658	electron transport chain
MADE_1006650	COG4656	Part of a membrane complex involved in electron transport
MADE_1006655	COG2878	Part of a membrane complex involved in electron transport
MADE_1006665	COG0534	Mate efflux family protein
MADE_1006670	COG0556	nucleotide-excision repair
MADE_1006685	COG0602	queuosine metabolic process
MADE_1006695	COG0367	asparagine synthase
MADE_1006720	COG3273	potassium ion transport
MADE_1006720	COG0471	metal ion transport
MADE_1006735	COG0529	Catalyzes the synthesis of activated sulfate
MADE_1006740	COG0175	sulfate reduction
MADE_1006745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MADE_1006750	COG2199	diguanylate cyclase activity
MADE_1006750	COG2203	Gaf domain
MADE_1006775	COG2304	oxidoreductase activity
MADE_1006795	COG0714	Associated with various cellular activities
MADE_1006820	COG2755	lipolytic protein G-D-S-L family
MADE_1006825	COG4181	ATPase activity
MADE_1006830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MADE_1006835	COG1090	epimerase
MADE_1006840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MADE_1006845	COG0628	permease
MADE_1006855	COG0745	RESPONSE REGULATOR receiver
MADE_1006870	COG2350	Protein conserved in bacteria
MADE_1006875	COG0159	tryptophan synthase activity
MADE_1006885	COG0134	indole-3-glycerol-phosphate synthase activity
MADE_1006885	COG0135	phosphoribosylanthranilate isomerase activity
MADE_1006890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MADE_1006900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MADE_1006905	COG0613	PHP domain protein
MADE_1006910	COG0009	L-threonylcarbamoyladenylate synthase
MADE_1006915	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MADE_1006920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MADE_1006930	COG0656	L-ascorbic acid biosynthetic process
MADE_1006935	COG0110	maltose O-acetyltransferase activity
MADE_1006945	COG2733	membrane
MADE_1006965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1006970	COG0500	methyltransferase
MADE_1006975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MADE_1006980	COG0497	DNA recombination
MADE_1006985	COG0783	Belongs to the Dps family
MADE_1006995	COG1454	alcohol dehydrogenase
MADE_1007000	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1007010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MADE_1007015	COG2610	gluconate transmembrane transporter activity
MADE_1007020	COG4771	TonB-dependent receptor
MADE_1007040	COG2801	Transposase and inactivated derivatives
MADE_1007045	COG2202	Pas domain
MADE_1007045	COG2205	protein histidine kinase activity
MADE_1007050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MADE_1007060	COG0484	heat shock protein binding
MADE_1007065	COG3909	cytochrome
MADE_1007070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MADE_1007085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MADE_1007090	COG0505	Belongs to the CarA family
MADE_1007095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MADE_1007100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MADE_1007120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MADE_1007125	COG0857	belongs to the CobB CobQ family
MADE_1007125	COG0280	phosphate acetyltransferase
MADE_1007135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MADE_1007140	COG4535	Mg2 and Co2 transporter CorC
MADE_1007150	COG1702	phosphate starvation-inducible protein PhoH
MADE_1007160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_1007205	COG1607	acyl-coa hydrolase
MADE_1007210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MADE_1007220	COG1115	amino acid carrier protein
MADE_1007230	COG0189	ligase activity
MADE_1007260	COG0156	8-amino-7-oxononanoate synthase activity
MADE_1007265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_1007275	COG3340	Belongs to the peptidase S51 family
MADE_1007280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MADE_1007285	COG4139	cobalamin transport
MADE_1007290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MADE_1007295	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MADE_1007310	COG5265	(ABC) transporter
MADE_1007315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MADE_1007325	COG0745	RESPONSE REGULATOR receiver
MADE_1007350	COG3300	MHYT domain
MADE_1007350	COG5001	Diguanylate cyclase
MADE_1007385	COG2801	Transposase and inactivated derivatives
MADE_1007395	COG1960	acyl-CoA dehydrogenase activity
MADE_1007410	COG1560	Kdo2-lipid A biosynthetic process
MADE_1007440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MADE_1007440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MADE_1007445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MADE_1007445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MADE_1007450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MADE_1007450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MADE_1007455	COG3409	Peptidoglycan-binding domain 1 protein
MADE_1007455	COG3267	Type II secretory pathway component ExeA
MADE_1007465	COG0489	protein tyrosine kinase activity
MADE_1007480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MADE_1007535	COG3562	capsule polysaccharide
MADE_1007540	COG0463	Glycosyl transferase, family 2
MADE_1007550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MADE_1007555	COG0012	GTP binding
MADE_1007575	COG1064	alcohol dehydrogenase
MADE_1007595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MADE_1007600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MADE_1007640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MADE_1007650	COG2890	protein-(glutamine-N5) methyltransferase activity
MADE_1007655	COG0784	Response regulator, receiver
MADE_1007655	COG3437	response regulator, receiver
MADE_1007665	COG3094	Invasion gene expression up-regulator, SirB
MADE_1007680	COG0583	DNA-binding transcription factor activity
MADE_1007690	COG2363	Small membrane protein
MADE_1007715	COG0515	serine threonine protein kinase
MADE_1007720	COG2116	formate transmembrane transporter activity
MADE_1007735	COG0714	Associated with various cellular activities
MADE_1007740	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MADE_1007745	COG0033	Phosphoglucomutase
MADE_1007750	COG0058	SHG alpha-glucan phosphorylase activity
MADE_1007760	COG2988	succinylglutamate desuccinylase activity
MADE_1007795	COG1393	Belongs to the ArsC family
MADE_1007850	COG3300	MHYT domain
MADE_1007850	COG5001	Diguanylate cyclase
MADE_1007880	COG2249	NAD(P)H dehydrogenase (quinone) activity
MADE_1007900	COG1733	regulation of RNA biosynthetic process
MADE_1007905	COG3447	MASE1 domain protein
MADE_1007905	COG5002	protein histidine kinase activity
MADE_1007905	COG5001	Diguanylate cyclase
MADE_1007915	COG0402	S-adenosylhomocysteine deaminase activity
MADE_1007920	COG2351	hydroxyisourate hydrolase activity
MADE_1007935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MADE_1007945	COG1309	transcriptional regulator
MADE_1007960	COG2252	PERMEase
MADE_1007965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MADE_1007980	COG4251	negative regulation of phosphorylation
MADE_1007980	COG3706	GGDEF domain
MADE_1007980	COG5001	Diguanylate cyclase
MADE_1007980	COG2203	Gaf domain
MADE_1007985	COG0745	RESPONSE REGULATOR receiver
MADE_1007985	COG3706	GGDEF domain
MADE_1007990	COG0784	Response regulator, receiver
MADE_1007990	COG2205	protein histidine kinase activity
MADE_1008005	COG2233	PERMEase
MADE_1008020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MADE_1008025	COG0730	response to heat
MADE_1008070	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1008085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MADE_1008100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MADE_1008100	COG0662	Cupin 2, conserved barrel domain protein
MADE_1008105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MADE_1008115	COG1596	polysaccharide export
MADE_1008120	COG0489	protein tyrosine kinase activity
MADE_1008125	COG4464	protein tyrosine phosphatase activity
MADE_1008150	COG5001	Diguanylate cyclase
MADE_1008150	COG3300	MHYT domain
MADE_1008180	COG1215	transferase activity, transferring glycosyl groups
MADE_1008190	COG2244	polysaccharide biosynthetic process
MADE_1008215	COG0438	transferase activity, transferring glycosyl groups
MADE_1008220	COG1484	DNA-dependent DNA replication
MADE_1008225	COG4584	PFAM Integrase catalytic
MADE_1008240	COG3039	Transposase
MADE_1008245	COG2755	lipolytic protein G-D-S-L family
MADE_1008245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MADE_1008265	COG0297	glycogen (starch) synthase activity
MADE_1008280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_1008280	COG0072	phenylalanine-tRNA ligase activity
MADE_1008305	COG1472	Belongs to the glycosyl hydrolase 3 family
MADE_1008310	COG2096	Adenosyltransferase
MADE_1008320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MADE_1008330	COG4591	ABC-type transport system involved in lipoprotein release permease component
MADE_1008355	COG0708	Exodeoxyribonuclease III
MADE_1008390	COG2814	Major facilitator Superfamily
MADE_1008435	COG1024	Enoyl-CoA hydratase
MADE_1008440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MADE_1008445	COG1960	acyl-CoA dehydrogenase activity
MADE_1008450	COG0789	Transcriptional regulator
MADE_1008455	COG0183	Belongs to the thiolase family
MADE_1008470	COG3706	GGDEF domain
MADE_1008480	COG2925	Exonuclease
MADE_1008535	COG1643	Atp-dependent helicase
MADE_1008555	COG0604	alcohol dehydrogenase
MADE_1008555	COG3321	synthase
MADE_1008560	COG0328	RNA-DNA hybrid ribonuclease activity
MADE_1008565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MADE_1008585	COG0457	Tetratricopeptide repeat
MADE_1008600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MADE_1008600	COG0574	Belongs to the PEP-utilizing enzyme family
MADE_1008625	COG0746	molybdenum cofactor guanylyltransferase activity
MADE_1008630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MADE_1008635	COG0243	molybdopterin cofactor binding
MADE_1008640	COG2153	protein acetylation
MADE_1008655	COG1530	ribonuclease E activity
MADE_1008660	COG0564	pseudouridine synthase activity
MADE_1008670	COG0424	maF-like protein
MADE_1008675	COG1399	metal-binding, possibly nucleic acid-binding protein
MADE_1008695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MADE_1008705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MADE_1008710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MADE_1008720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MADE_1008735	COG0084	hydrolase, TatD family'
MADE_1008745	COG0702	epimerase
MADE_1008750	COG3706	GGDEF domain
MADE_1008770	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1008775	COG0596	Alpha beta hydrolase
MADE_1008785	COG0183	Belongs to the thiolase family
MADE_1008790	COG1960	acyl-CoA dehydrogenase activity
MADE_1008795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MADE_1008800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1008815	COG4948	Mandelate Racemase Muconate Lactonizing
MADE_1008825	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1008830	COG1960	acyl-CoA dehydrogenase activity
MADE_1008845	COG0348	domain, Protein
MADE_1008855	COG0246	Mannitol dehydrogenase
MADE_1008860	COG3039	Transposase
MADE_1008885	COG0668	transmembrane transport
MADE_1008890	COG4771	TonB-dependent receptor
MADE_1008905	COG3437	response regulator, receiver
MADE_1008915	COG0195	Participates in both transcription termination and antitermination
MADE_1008930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MADE_1008945	COG1187	pseudouridine synthase activity
MADE_1008955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MADE_1008955	COG3153	acetyltransferase
MADE_1008995	COG0450	alkyl hydroperoxide reductase
MADE_1009040	COG1032	radical SAM domain protein
MADE_1009055	COG4771	TonB-dependent receptor
MADE_1009060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_1009070	COG4134	Bacterial extracellular solute-binding protein
MADE_1009080	COG4136	ATPase activity
MADE_1009085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MADE_1009110	COG2203	Gaf domain
MADE_1009110	COG3706	GGDEF domain
MADE_1009110	COG4251	negative regulation of phosphorylation
MADE_1009110	COG5001	Diguanylate cyclase
MADE_1009155	COG1131	(ABC) transporter
MADE_1009160	COG1902	pentaerythritol trinitrate reductase activity
MADE_1009170	COG2867	negative regulation of translational initiation
MADE_1009175	COG2914	Belongs to the UPF0125 (RnfH) family
MADE_1009185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_1009235	COG2226	methyltransferase
MADE_1009250	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1009290	COG2801	Transposase and inactivated derivatives
MADE_1009300	COG2801	Transposase and inactivated derivatives
MADE_1009360	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MADE_1009365	COG1196	nuclear chromosome segregation
MADE_1009410	COG1663	tetraacyldisaccharide 4'-kinase activity
MADE_1009445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MADE_1009450	COG0435	Glutathione S-transferase
MADE_1009455	COG1741	Belongs to the pirin family
MADE_1009460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MADE_1009470	COG0372	Belongs to the citrate synthase family
MADE_1009475	COG2009	succinate dehydrogenase
MADE_1009480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MADE_1009485	COG1053	succinate dehydrogenase
MADE_1009490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MADE_1009495	COG0567	Dehydrogenase, E1 component
MADE_1009500	COG0508	dehydrogenase complex catalyzes the overall conversion of
MADE_1009535	COG4667	esterase of the alpha-beta hydrolase superfamily
MADE_1009560	COG0366	Alpha amylase catalytic
MADE_1009585	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1009590	COG2267	carboxylic ester hydrolase activity
MADE_1009600	COG0616	signal peptide processing
MADE_1009620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_1009625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MADE_1009630	COG0386	Belongs to the glutathione peroxidase family
MADE_1009635	COG2084	Dehydrogenase
MADE_1009645	COG1960	acyl-CoA dehydrogenase activity
MADE_1009650	COG1024	Enoyl-CoA hydratase
MADE_1009660	COG2226	methyltransferase
MADE_1009665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MADE_1009670	COG3083	sulfuric ester hydrolase activity
MADE_1009675	COG3082	Protein of unknown function (DUF1414)
MADE_1009680	COG3081	Nucleoid-associated protein
MADE_1009710	COG3275	phosphorelay sensor kinase activity
MADE_1009715	COG3279	Response regulator of the LytR AlgR family
MADE_1009720	COG0205	6-phosphofructokinase activity
MADE_1009740	COG5433	transposase activity
MADE_1009760	COG4221	oxidoreductase activity
MADE_1009765	COG0583	DNA-binding transcription factor activity
MADE_1009805	COG2205	protein histidine kinase activity
MADE_1009805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_1009825	COG0513	Belongs to the DEAD box helicase family
MADE_1009835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MADE_1009840	COG0583	DNA-binding transcription factor activity
MADE_1009885	COG1322	Protein conserved in bacteria
MADE_1009890	COG1404	Belongs to the peptidase S8 family
MADE_1009900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MADE_1009905	COG0022	dehydrogenase e1 component
MADE_1009915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MADE_1009920	COG0515	serine threonine protein kinase
MADE_1009930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MADE_1009955	COG0583	DNA-binding transcription factor activity
MADE_1009960	COG0604	alcohol dehydrogenase
MADE_1009965	COG0753	catalase activity
MADE_1009975	COG0604	alcohol dehydrogenase
MADE_1009980	COG1733	regulation of RNA biosynthetic process
MADE_1009995	COG2268	Band 7 protein
MADE_1010005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MADE_1010010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MADE_1010015	COG0215	cysteine-tRNA ligase activity
MADE_1010040	COG1388	LysM domain
MADE_1010040	COG0741	lytic transglycosylase activity
MADE_1010045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MADE_1010050	COG2226	methyltransferase
MADE_1010055	COG0668	transmembrane transport
MADE_1010060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_1010060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MADE_1010065	COG0489	protein tyrosine kinase activity
MADE_1010075	COG0471	metal ion transport
MADE_1010110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MADE_1010120	COG1956	GAF domain-containing protein
MADE_1010135	COG0793	Belongs to the peptidase S41A family
MADE_1010140	COG0733	neurotransmitter:sodium symporter activity
MADE_1010150	COG0308	aminopeptidase N
MADE_1010165	COG2902	Dehydrogenase
MADE_1010170	COG0167	dihydroorotate dehydrogenase activity
MADE_1010195	COG0415	Belongs to the DNA photolyase family
MADE_1010200	COG0415	Belongs to the DNA photolyase family
MADE_1010205	COG0415	Belongs to the DNA photolyase family
MADE_1010210	COG0415	Belongs to the DNA photolyase family
MADE_1010215	COG3046	protein related to deoxyribodipyrimidine photolyase
MADE_1010305	COG4772	TonB-dependent receptor
MADE_1010360	COG4974	Belongs to the 'phage' integrase family
MADE_1010370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MADE_1010390	COG0069	glutamate synthase activity
MADE_1010400	COG2193	ferroxidase activity
MADE_1010410	COG3278	Belongs to the heme-copper respiratory oxidase family
MADE_1010445	COG2217	Heavy metal translocating P-type atpase
MADE_1010460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MADE_1010465	COG0589	response to stress
MADE_1010470	COG0037	tRNA processing
MADE_1010475	COG1752	Esterase of the alpha-beta hydrolase superfamily
MADE_1010500	COG1280	lysine exporter protein (LysE YggA)
MADE_1010505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MADE_1010510	COG2897	thiosulfate sulfurtransferase activity
MADE_1010515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MADE_1010550	COG2801	Transposase and inactivated derivatives
MADE_1010570	COG0582	viral genome integration into host DNA
MADE_1010575	COG0322	excinuclease ABC activity
MADE_1010620	COG0436	Aminotransferase
MADE_1010640	COG2259	Doxx family
MADE_1010645	COG0583	DNA-binding transcription factor activity
MADE_1010675	COG2920	part of a sulfur-relay system
MADE_1010690	COG4771	TonB-dependent receptor
MADE_1010705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MADE_1010710	COG0686	Belongs to the AlaDH PNT family
MADE_1010725	COG0284	orotidine-5'-phosphate decarboxylase activity
MADE_1010730	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MADE_1010765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MADE_1010770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MADE_1010775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MADE_1010780	COG0633	Ferredoxin
MADE_1010815	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MADE_1010835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MADE_1010845	COG4783	chaperone-mediated protein folding
MADE_1010855	COG1393	Belongs to the ArsC family
MADE_1010870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MADE_1010885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MADE_1010895	COG1960	acyl-CoA dehydrogenase activity
MADE_1010920	COG0572	uridine kinase
MADE_1010925	COG3769	mannosylglycerate metabolic process
MADE_1010930	COG1215	transferase activity, transferring glycosyl groups
MADE_1010935	COG0366	Alpha amylase catalytic
MADE_1010950	COG0534	Mate efflux family protein
MADE_1010965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MADE_1010970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MADE_1010985	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1011010	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1011030	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MADE_1011090	COG0405	Gamma-glutamyltransferase
MADE_1011475	COG2246	polysaccharide biosynthetic process
MADE_1011480	COG0463	Glycosyl transferase, family 2
MADE_1011485	COG0463	Glycosyl transferase, family 2
MADE_1011495	COG4372	Transposase
MADE_1011500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MADE_1011500	COG2755	lipolytic protein G-D-S-L family
MADE_1011525	COG0640	Transcriptional regulator
MADE_1011545	COG2204	response regulator
MADE_1011555	COG4251	negative regulation of phosphorylation
MADE_1011560	COG0784	Response regulator, receiver
MADE_1011565	COG2205	protein histidine kinase activity
MADE_1011565	COG0784	Response regulator, receiver
MADE_1011590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MADE_1011615	COG3139	Protein of unknown function (DUF1315)
MADE_1011630	COG1115	amino acid carrier protein
MADE_1011635	COG2866	Carboxypeptidase
MADE_1011655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MADE_1011665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MADE_1011670	COG1640	4-alpha-glucanotransferase
MADE_1011675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MADE_1011680	COG0676	glucose-6-phosphate 1-epimerase activity
MADE_1011685	COG0800	Aldolase
MADE_1011695	COG0129	dihydroxy-acid dehydratase activity
MADE_1011705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MADE_1011710	COG1737	Transcriptional regulator
MADE_1011715	COG0469	pyruvate kinase activity
MADE_1011720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_1011735	COG2823	Periplasmic or secreted lipoprotein
MADE_1011765	COG3665	Urea carboxylase-associated protein
MADE_1011800	COG2356	endonuclease I
MADE_1011820	COG0583	DNA-binding transcription factor activity
MADE_1011825	COG1979	alcohol dehydrogenase
MADE_1011840	COG0784	Response regulator, receiver
MADE_1011840	COG3437	response regulator, receiver
MADE_1011845	COG4191	Histidine kinase
MADE_1011845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MADE_1011880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MADE_1011885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MADE_1011890	COG0285	dihydrofolate synthase activity
MADE_1011915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MADE_1011920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MADE_1011940	COG3609	addiction module antidote protein, CC2985 family
MADE_1011950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MADE_1011955	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_1011970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MADE_1011970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MADE_1012005	COG0789	Transcriptional regulator
MADE_1012010	COG0604	alcohol dehydrogenase
MADE_1012015	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1012035	COG1119	ATPase activity
MADE_1012040	COG2031	fatty acid transporter
MADE_1012045	COG2205	protein histidine kinase activity
MADE_1012045	COG0784	Response regulator, receiver
MADE_1012045	COG5002	protein histidine kinase activity
MADE_1012055	COG0612	Peptidase, M16
MADE_1012070	COG3101	peptidyl-lysine hydroxylation
MADE_1012100	COG0446	pyridine nucleotide-disulphide oxidoreductase
MADE_1012100	COG1902	pentaerythritol trinitrate reductase activity
MADE_1012135	COG4399	Belongs to the UPF0754 family
MADE_1012155	COG1770	oligopeptidase
MADE_1012160	COG2186	Transcriptional regulator
MADE_1012170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MADE_1012175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MADE_1012185	COG2983	Belongs to the UPF0260 family
MADE_1012190	COG0179	Fumarylacetoacetate (FAA) hydrolase
MADE_1012205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MADE_1012210	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_1012215	COG2267	carboxylic ester hydrolase activity
MADE_1012230	COG1214	PFAM Peptidase M22, glycoprotease
MADE_1012235	COG1199	ATP-dependent helicase activity
MADE_1012285	COG4771	TonB-dependent receptor
MADE_1012295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MADE_1012300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MADE_1012305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MADE_1012310	COG0131	Imidazoleglycerol-phosphate dehydratase
MADE_1012310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MADE_1012315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MADE_1012345	COG0564	pseudouridine synthase activity
MADE_1012360	COG1595	DNA-templated transcription, initiation
MADE_1012375	COG4221	oxidoreductase activity
MADE_1012390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MADE_1012400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MADE_1012410	COG0142	geranyltranstransferase activity
MADE_1012420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MADE_1012425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MADE_1012435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MADE_1012450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MADE_1012450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MADE_1012470	COG0488	(ABC) transporter
MADE_1012480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MADE_1012490	COG0560	Phosphoserine phosphatase
MADE_1012500	COG0084	hydrolase, TatD family'
MADE_1012510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MADE_1012515	COG0571	ribonuclease III activity
MADE_1012520	COG0681	Belongs to the peptidase S26 family
MADE_1012545	COG1595	DNA-templated transcription, initiation
MADE_1012550	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MADE_1012565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MADE_1012645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MADE_1012650	COG1047	Peptidyl-prolyl cis-trans
MADE_1012670	COG0196	riboflavin kinase activity
MADE_1012675	COG0728	peptidoglycan biosynthetic process
MADE_1012680	COG0268	Binds directly to 16S ribosomal RNA
MADE_1012695	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1012700	COG0385	Bile acid
MADE_1012730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_1012735	COG0776	regulation of translation
MADE_1012745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MADE_1012750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MADE_1012755	COG0740	serine-type endopeptidase activity
MADE_1012760	COG0544	peptidyl-prolyl cis-trans isomerase activity
MADE_1012865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MADE_1012875	COG2166	iron-sulfur cluster assembly
MADE_1012890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MADE_1012895	COG0719	Fe-S assembly protein
MADE_1012900	COG0396	ATPase activity
MADE_1012905	COG0719	Fe-S assembly protein
MADE_1012910	COG1104	cysteine desulfurase activity
MADE_1012920	COG2072	flavoprotein involved in K transport
MADE_1012925	COG1045	serine acetyltransferase
MADE_1012930	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MADE_1012935	COG0483	inositol monophosphate 1-phosphatase activity
MADE_1012950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_1012955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MADE_1012960	COG1862	Preprotein translocase
MADE_1012985	COG1842	Phage shock protein A
MADE_1012990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MADE_1013010	COG0754	glutathionylspermidine amidase activity
MADE_1013040	COG2066	Belongs to the glutaminase family
MADE_1013045	COG1785	Belongs to the alkaline phosphatase family
MADE_1013170	COG0367	asparagine synthase
MADE_1013190	COG0438	transferase activity, transferring glycosyl groups
MADE_1013225	COG2116	formate transmembrane transporter activity
MADE_1013230	COG0840	transmembrane signaling receptor activity
MADE_1013255	COG0326	Molecular chaperone. Has ATPase activity
MADE_1013260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MADE_1013285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MADE_1013290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MADE_1013300	COG3220	belongs to the UPF0276 family
MADE_1013320	COG4251	negative regulation of phosphorylation
MADE_1013320	COG2203	Gaf domain
MADE_1013320	COG5001	Diguanylate cyclase
MADE_1013320	COG3706	GGDEF domain
MADE_1013330	COG0596	Alpha beta hydrolase
MADE_1013340	COG0716	FMN binding
MADE_1013350	COG0735	belongs to the Fur family
MADE_1013360	COG1984	allophanate hydrolase subunit 2
MADE_1013365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MADE_1013370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MADE_1013375	COG2996	Protein conserved in bacteria
MADE_1013380	COG1765	OsmC-like protein
MADE_1013385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1013410	COG0436	Aminotransferase
MADE_1013415	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MADE_1013420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MADE_1013445	COG3012	SEC-C Motif Domain Protein
MADE_1013460	COG0604	alcohol dehydrogenase
MADE_1013470	COG1960	acyl-CoA dehydrogenase activity
MADE_1013480	COG4771	TonB-dependent receptor
MADE_1013500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MADE_1013505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MADE_1013525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MADE_1013535	COG0521	Mo-molybdopterin cofactor biosynthetic process
MADE_1013540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MADE_1013550	COG2161	toxin-antitoxin pair type II binding
MADE_1013555	COG4115	mRNA cleavage
MADE_1013570	COG0436	Aminotransferase
MADE_1013575	COG3268	Saccharopine dehydrogenase
MADE_1013580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MADE_1013595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MADE_1013600	COG4206	TonB-dependent receptor
MADE_1013610	COG5006	permease, DMT superfamily
MADE_1013625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MADE_1013630	COG1074	ATP-dependent DNA helicase activity
MADE_1013635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MADE_1013650	COG1022	Amp-dependent synthetase and ligase
MADE_1013655	COG4251	negative regulation of phosphorylation
MADE_1013655	COG5001	Diguanylate cyclase
MADE_1013655	COG2203	Gaf domain
MADE_1013655	COG3706	GGDEF domain
MADE_1013675	COG0583	DNA-binding transcription factor activity
MADE_1013705	COG1448	Aminotransferase
MADE_1013715	COG1671	Belongs to the UPF0178 family
MADE_1013720	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1013725	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1013730	COG1960	acyl-CoA dehydrogenase activity
MADE_1013735	COG0662	Cupin 2, conserved barrel domain protein
MADE_1013735	COG2207	Transcriptional regulator
MADE_1013750	COG1505	serine-type exopeptidase activity
MADE_1013760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1013805	COG1091	dTDP-4-dehydrorhamnose reductase activity
MADE_1013860	COG2801	Transposase and inactivated derivatives
MADE_1013895	COG3119	arylsulfatase activity
MADE_1013910	COG0438	transferase activity, transferring glycosyl groups
MADE_1013910	COG1216	Glycosyl transferase, family 2
MADE_1013915	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MADE_1013915	COG0662	Cupin 2, conserved barrel domain protein
MADE_1013935	COG0202	RNA polymerase activity
MADE_1013960	COG0201	protein transport
MADE_1013980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MADE_1014030	COG1960	acyl-CoA dehydrogenase activity
MADE_1014060	COG0745	RESPONSE REGULATOR receiver
MADE_1014065	COG2205	protein histidine kinase activity
MADE_1014115	COG2080	2 iron, 2 sulfur cluster binding
MADE_1014120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MADE_1014125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MADE_1014145	COG1028	Short-chain dehydrogenase reductase Sdr
MADE_1014150	COG4221	oxidoreductase activity
MADE_1014155	COG0693	protein deglycase activity
MADE_1014160	COG1295	ribonuclease BN
MADE_1014170	COG4681	YaeQ
MADE_1014200	COG2814	Major facilitator Superfamily
MADE_1014215	COG0514	ATP-dependent DNA helicase (RecQ)
MADE_1014245	COG4251	negative regulation of phosphorylation
MADE_1014250	COG2133	pyrroloquinoline quinone binding
MADE_1014270	COG0830	nickel cation binding
MADE_1014295	COG0829	nickel cation binding
MADE_1014300	COG0410	ABC transporter
MADE_1014335	COG0745	RESPONSE REGULATOR receiver
MADE_1014340	COG3177	Filamentation induced by cAMP protein fic
MADE_1014380	COG1518	maintenance of DNA repeat elements
MADE_1014415	COG1203	CRISPR-associated helicase, Cas3
MADE_1014440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MADE_1014445	COG2971	BadF BadG BcrA BcrD
MADE_1014450	COG0583	DNA-binding transcription factor activity
MADE_1014455	COG1620	l-lactate permease
MADE_1014480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_1014485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MADE_1014490	COG0006	proline dipeptidase activity
MADE_1014885	COG0582	viral genome integration into host DNA
MADE_1014890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_1014905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MADE_1014910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MADE_1014915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MADE_1014935	COG3313	Fe-S protein
MADE_1014970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_1014975	COG0508	dehydrogenase complex catalyzes the overall conversion of
MADE_1014980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MADE_1014985	COG2186	Transcriptional regulator
MADE_1014995	COG3023	N-Acetylmuramoyl-L-alanine amidase
MADE_1015000	COG3577	Aspartyl protease
MADE_1015005	COG0157	Belongs to the NadC ModD family
MADE_1015015	COG1459	type II secretion system
MADE_1015020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MADE_1015045	COG3608	succinylglutamate desuccinylase aspartoacylase
MADE_1015050	COG0840	transmembrane signaling receptor activity
MADE_1015055	COG4566	intracellular signal transduction
MADE_1015060	COG1192	Involved in chromosome partitioning
MADE_1015070	COG2198	Histidine kinase
MADE_1015070	COG0643	Histidine kinase
MADE_1015075	COG0745	RESPONSE REGULATOR receiver
MADE_1015080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MADE_1015090	COG2201	protein-glutamate methylesterase activity
MADE_1015095	COG0835	chemotaxis
MADE_1015100	COG0840	transmembrane signaling receptor activity
MADE_1015105	COG0494	nUDIX hydrolase
MADE_1015115	COG0739	heme binding
MADE_1015120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MADE_1015125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MADE_1015140	COG1181	Belongs to the D-alanine--D-alanine ligase family
MADE_1015145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MADE_1015155	COG0772	Belongs to the SEDS family
MADE_1015160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MADE_1015170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MADE_1015175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MADE_1015180	COG0768	penicillin binding
MADE_1015185	COG3116	cell division
MADE_1015195	COG2001	Belongs to the MraZ family
MADE_1015250	COG0678	peroxiredoxin activity
MADE_1015250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MADE_1015265	COG3706	GGDEF domain
MADE_1015275	COG2204	response regulator
MADE_1015280	COG2205	protein histidine kinase activity
MADE_1015280	COG0784	Response regulator, receiver
MADE_1015310	COG0668	transmembrane transport
MADE_1015315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MADE_1015320	COG0189	ligase activity
MADE_1015325	COG1678	Uncharacterized ACR, COG1678
MADE_1015330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MADE_1015355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MADE_1015360	COG0762	integral membrane protein
MADE_1015370	COG0446	pyridine nucleotide-disulphide oxidoreductase
MADE_1015370	COG1902	pentaerythritol trinitrate reductase activity
MADE_1015385	COG0625	glutathione transferase activity
MADE_1015395	COG1764	response to oxidative stress
MADE_1015400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MADE_1015415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MADE_1015425	COG2814	Major facilitator Superfamily
MADE_1015430	COG0724	RNA recognition motif
MADE_1015465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MADE_1015470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MADE_1015475	COG0083	homoserine kinase activity
MADE_1015490	COG0583	DNA-binding transcription factor activity
MADE_1015505	COG0640	Transcriptional regulator
MADE_1015515	COG0431	NADPH-dependent FMN reductase
MADE_1015520	COG0798	PFAM Bile acid sodium symporter
MADE_1015525	COG2201	protein-glutamate methylesterase activity
MADE_1015530	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MADE_1015540	COG0642	Histidine kinase
MADE_1015570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MADE_1015600	COG1748	Saccharopine dehydrogenase
MADE_1015615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MADE_1015620	COG3107	peptidoglycan biosynthetic process
MADE_1015635	COG0438	transferase activity, transferring glycosyl groups
MADE_1015645	COG2823	Periplasmic or secreted lipoprotein
MADE_1015665	COG4585	Histidine kinase
MADE_1015670	COG2197	response regulator
MADE_1015695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MADE_1015705	COG0372	Belongs to the citrate synthase family
MADE_1015710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MADE_1015715	COG2828	Protein conserved in bacteria
MADE_1015720	COG2203	Gaf domain
MADE_1015720	COG2199	diguanylate cyclase activity
MADE_1015725	COG1940	carbohydrate kinase activity
MADE_1015740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MADE_1015745	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MADE_1015770	COG2198	Histidine kinase
MADE_1015770	COG5002	protein histidine kinase activity
MADE_1015770	COG0784	Response regulator, receiver
MADE_1015775	COG3023	N-Acetylmuramoyl-L-alanine amidase
MADE_1015790	COG0493	'glutamate synthase
MADE_1015805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MADE_1015810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MADE_1015815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MADE_1015820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MADE_1015835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MADE_1015840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MADE_1015850	COG4942	peptidase
MADE_1015855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MADE_1015860	COG0738	Major facilitator superfamily
MADE_1015870	COG1902	pentaerythritol trinitrate reductase activity
MADE_1015890	COG0625	glutathione transferase activity
MADE_1015915	COG2894	cell division
MADE_1015920	COG0850	regulation of cytokinetic process
MADE_1015930	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MADE_1015960	COG1914	H( )-stimulated, divalent metal cation uptake system
MADE_1015965	COG0436	Aminotransferase
MADE_1015985	COG0174	glutamine synthetase
MADE_1015995	COG3852	Histidine kinase
MADE_1016000	COG2204	response regulator
MADE_1016005	COG3437	response regulator, receiver
MADE_1016010	COG0204	Acyl-transferase
MADE_1016025	COG3706	GGDEF domain
MADE_1016045	COG3850	Histidine kinase
MADE_1016045	COG4999	Histidine kinase
MADE_1016045	COG2205	protein histidine kinase activity
MADE_1016045	COG3437	response regulator, receiver
MADE_1016050	COG0525	valine-tRNA ligase activity
MADE_1016055	COG2927	DNA polymerase III (CHI subunit)
MADE_1016060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MADE_1016065	COG0795	lipopolysaccharide-transporting ATPase activity
MADE_1016070	COG0795	lipopolysaccharide-transporting ATPase activity
MADE_1016150	COG0673	inositol 2-dehydrogenase activity
MADE_1016180	COG2801	Transposase and inactivated derivatives
MADE_1016190	COG1858	cytochrome C peroxidase
MADE_1016210	COG3547	Transposase (IS116 IS110 IS902 family)
MADE_1016245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MADE_1016250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MADE_1016255	COG4558	Periplasmic binding protein
MADE_1016265	COG4206	TonB-dependent receptor
MADE_1016275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MADE_1016280	COG0697	spore germination
MADE_1016315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MADE_1016330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MADE_1016375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MADE_1016380	COG0277	FAD linked oxidase domain protein
MADE_1016390	COG1462	curli production assembly transport component CsgG
MADE_1016420	COG2197	response regulator
MADE_1016435	COG0513	Belongs to the DEAD box helicase family
MADE_1016445	COG5001	Diguanylate cyclase
MADE_1016460	COG0800	Aldolase
MADE_1016465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_1016510	COG2337	Toxic component of a toxin-antitoxin (TA) module
MADE_1016540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MADE_1016570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MADE_1016590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MADE_1016590	COG3264	Mechanosensitive ion channel
MADE_1016635	COG0730	response to heat
MADE_1016655	COG4191	Histidine kinase
MADE_1016665	COG0417	DNA replication proofreading
MADE_1016675	COG0318	PFAM AMP-dependent synthetase and ligase
MADE_1016695	COG1309	transcriptional regulator
MADE_1016705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_1016715	COG1573	uracil-dna glycosylase
MADE_1016720	COG3300	MHYT domain
MADE_1016720	COG5001	Diguanylate cyclase
MADE_1016740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MADE_1016760	COG1983	PspC domain protein
MADE_1016765	COG1842	Phage shock protein A
MADE_1016775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_1016780	COG0582	viral genome integration into host DNA
MADE_1016790	COG4372	Transposase
MADE_1016840	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MADE_1016930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MADE_1016930	COG2885	chlorophyll binding
MADE_1016935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MADE_1016945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MADE_1016950	COG0204	Acyl-transferase
MADE_1016955	COG0204	Acyl-transferase
MADE_1016960	COG0668	transmembrane transport
MADE_1016975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MADE_1016980	COG0733	neurotransmitter:sodium symporter activity
MADE_1016995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MADE_1017015	COG0716	FMN binding
MADE_1017375	COG0840	transmembrane signaling receptor activity
MADE_1017380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MADE_1018020	COG0557	exoribonuclease II activity
MADE_1018050	COG4771	TonB-dependent receptor
MADE_1018065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MADE_1018095	COG2234	aminopeptidase activity
MADE_1018105	COG4251	negative regulation of phosphorylation
MADE_1018115	COG1271	oxidase subunit
MADE_1018120	COG1294	oxidase, subunit
MADE_1018130	COG1522	sequence-specific DNA binding
MADE_1018140	COG1278	Cold shock
MADE_1018145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MADE_1018165	COG0339	signal peptide processing
MADE_1018170	COG0745	RESPONSE REGULATOR receiver
MADE_1018180	COG3852	Histidine kinase
MADE_1018190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MADE_1018195	COG0243	molybdopterin cofactor binding
MADE_1018200	COG0823	Involved in the tonB-independent uptake of proteins
MADE_1018200	COG4946	Tricorn protease homolog
MADE_1018200	COG1506	peptidase
MADE_1018250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MADE_1018260	COG2197	response regulator
MADE_1018270	COG0189	ligase activity
MADE_1018290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MADE_1018295	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MADE_1018300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MADE_1018315	COG0281	malic enzyme
MADE_1018325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MADE_1018355	COG0456	acetyltransferase
MADE_1018365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MADE_1018370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MADE_1018375	COG2177	Part of the ABC transporter FtsEX involved in
MADE_1018380	COG2884	Cell division ATP-binding protein ftsE
MADE_1018385	COG0552	protein localization to endoplasmic reticulum
MADE_1018390	COG0742	ribosomal rna small subunit methyltransferase
MADE_1018400	COG2095	MarC family integral membrane protein
MADE_1018420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MADE_1018425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MADE_1018430	COG0617	tRNA 3'-terminal CCA addition
MADE_1018435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MADE_1018450	COG0076	glutamate decarboxylase activity
MADE_1018465	COG0842	Transport permease protein
MADE_1018470	COG1131	(ABC) transporter
MADE_1018475	COG0745	RESPONSE REGULATOR receiver
MADE_1018480	COG2205	protein histidine kinase activity
MADE_1018485	COG4774	siderophore transport
MADE_1018505	COG1253	flavin adenine dinucleotide binding
MADE_1018515	COG1966	Carbon starvation protein
MADE_1018540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MADE_1018545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MADE_1018925	COG2258	MOSC domain
MADE_1018955	COG2205	protein histidine kinase activity
MADE_1018975	COG0840	transmembrane signaling receptor activity
MADE_1018980	COG5002	protein histidine kinase activity
MADE_1019030	COG1472	Belongs to the glycosyl hydrolase 3 family
MADE_1019040	COG2723	6-phospho-beta-galactosidase activity
MADE_1019045	COG1609	Transcriptional regulator
MADE_1019050	COG2814	Major facilitator Superfamily
MADE_1019055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MADE_1019060	COG4988	ABC transporter
MADE_1019065	COG4890	Cyd operon protein YbgT
MADE_1019070	COG1294	oxidase, subunit
MADE_1019085	COG2204	response regulator
MADE_1019110	COG4319	ketosteroid isomerase
MADE_1019130	COG2375	cellular response to nickel ion
MADE_1019135	COG3237	CsbD-like
MADE_1019180	COG3038	cytochrome b561
MADE_1019215	COG2067	long-chain fatty acid transport protein
MADE_1019220	COG2130	NADP-dependent
MADE_1019225	COG2203	Gaf domain
MADE_1019225	COG4251	negative regulation of phosphorylation
MADE_1019225	COG3706	GGDEF domain
MADE_1019225	COG5001	Diguanylate cyclase
MADE_1019230	COG2205	protein histidine kinase activity
MADE_1019230	COG0784	Response regulator, receiver
MADE_1019255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_1019260	COG2181	nitrate reductase activity
MADE_1019265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MADE_1019275	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MADE_1019280	COG3850	Histidine kinase
MADE_1019285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MADE_1019305	COG2197	response regulator
MADE_1019325	COG0314	molybdopterin synthase activity
MADE_1019330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MADE_1019345	COG0746	molybdenum cofactor guanylyltransferase activity
MADE_1019350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MADE_1019370	COG0028	Belongs to the TPP enzyme family
MADE_1019395	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MADE_1019400	COG3604	Transcriptional regulator
MADE_1019405	COG3094	Invasion gene expression up-regulator, SirB
MADE_1019420	COG2223	nitrite transmembrane transporter activity
MADE_1019425	COG0515	serine threonine protein kinase
MADE_1019435	COG1136	(ABC) transporter
MADE_1019455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MADE_1019460	COG1349	DNA-binding transcription factor activity
MADE_1019465	COG0673	inositol 2-dehydrogenase activity
MADE_1019480	COG0697	spore germination
MADE_1019485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MADE_1019495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MADE_1019500	COG1166	arginine decarboxylase activity
MADE_1019510	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MADE_1019515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MADE_1019520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MADE_1019565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MADE_1019570	COG0109	protoheme IX farnesyltransferase activity
MADE_1019590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MADE_1019635	COG3030	protein affecting phage T7 exclusion by the F plasmid
MADE_1019640	COG1324	tolerance protein
MADE_1019645	COG4232	protein-disulfide reductase activity
MADE_1019650	COG0739	heme binding
MADE_1019655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MADE_1019660	COG0511	ligase activity, forming carbon-carbon bonds
MADE_1019665	COG0439	Biotin carboxylase
MADE_1019715	COG0154	amidase activity
MADE_1019730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MADE_1019735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MADE_1019765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MADE_1019770	COG3954	Phosphoribulokinase
MADE_1019780	COG0745	RESPONSE REGULATOR receiver
MADE_1019800	COG1501	Belongs to the glycosyl hydrolase 31 family
MADE_1019810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MADE_1019830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MADE_1019835	COG1459	type II secretion system
MADE_1019840	COG2165	general secretion pathway protein
MADE_1019845	COG2165	general secretion pathway protein
MADE_1019850	COG2165	general secretion pathway protein
MADE_1019855	COG4795	General secretion pathway protein
MADE_1019870	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MADE_1019885	COG1012	belongs to the aldehyde dehydrogenase family
MADE_1019895	COG1011	Hydrolase
MADE_1019905	COG1218	3'(2'),5'-bisphosphate nucleotidase
MADE_1019930	COG3089	Belongs to the UPF0270 family
MADE_1019935	COG0429	hydrolase of the alpha beta-hydrolase fold
MADE_1019965	COG2900	Belongs to the SlyX family
MADE_1019975	COG0545	Peptidyl-prolyl cis-trans isomerase
MADE_1019985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MADE_1020010	COG0596	Alpha beta hydrolase
MADE_1020015	COG1040	competence protein
MADE_1020035	COG1794	racemase activity, acting on amino acids and derivatives
MADE_1020050	COG0726	polysaccharide deacetylase
MADE_1020050	COG1649	PFAM Uncharacterised BCR, COG1649
MADE_1020060	COG1999	signal sequence binding
MADE_1020065	COG0109	protoheme IX farnesyltransferase activity
MADE_1020070	COG1612	heme a metabolic process
MADE_1020095	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MADE_1020100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MADE_1020105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MADE_1020125	COG0129	dihydroxy-acid dehydratase activity
MADE_1020140	COG0583	DNA-binding transcription factor activity
MADE_1020150	COG2814	Major facilitator Superfamily
MADE_1020160	COG0729	surface antigen
MADE_1020165	COG2911	Protein conserved in bacteria
MADE_1020190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MADE_1020200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MADE_1020220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MADE_1020245	COG1228	amidohydrolase
MADE_1020270	COG0425	Belongs to the sulfur carrier protein TusA family
MADE_1020290	COG1561	YicC-like family, N-terminal region
MADE_1020300	COG3550	peptidyl-serine autophosphorylation
MADE_1020305	COG3620	sequence-specific DNA binding
MADE_1020395	COG3177	Filamentation induced by cAMP protein fic
MADE_1020405	COG1609	Transcriptional regulator
MADE_1020420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MADE_1020420	COG2199	diguanylate cyclase activity
MADE_1020445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MADE_1020475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MADE_1020495	COG1475	DNA binding
MADE_1020500	COG1192	Involved in chromosome partitioning
MADE_1020525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MADE_1020530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MADE_1020550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane