locus-tag	class	description
amad1_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
amad1_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
amad1_00025	COG0187	DNA topoisomerase II activity
amad1_00045	COG2818	Glycosylase
amad1_00055	COG3078	GTPase activator activity
amad1_00075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
amad1_00075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
amad1_00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
amad1_00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
amad1_00090	COG0569	domain protein
amad1_00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
amad1_00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
amad1_00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
amad1_00115	COG0758	DNA mediated transformation
amad1_00130	COG0009	L-threonylcarbamoyladenylate synthase
amad1_00135	COG0408	coproporphyrinogen oxidase activity
amad1_00140	COG3047	cAMP biosynthetic process
amad1_00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
amad1_00215	COG2234	aminopeptidase activity
amad1_00220	COG0463	Glycosyl transferase, family 2
amad1_00230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
amad1_00255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
amad1_00285	COG3642	lipopolysaccharide core region biosynthetic process
amad1_00290	COG0859	PFAM glycosyl transferase family 9
amad1_00320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
amad1_00335	COG3161	chorismate lyase activity
amad1_00340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
amad1_00360	COG0210	DNA helicase
amad1_00405	COG1959	2 iron, 2 sulfur cluster binding
amad1_00410	COG0730	response to heat
amad1_00425	COG4771	TonB-dependent receptor
amad1_00440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
amad1_00445	COG4988	ABC transporter
amad1_00455	COG1271	oxidase subunit
amad1_00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
amad1_00465	COG0425	Belongs to the sulfur carrier protein TusA family
amad1_00475	COG0450	alkyl hydroperoxide reductase
amad1_00485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
amad1_00515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
amad1_00560	COG0270	DNA (cytosine-5-)-methyltransferase activity
amad1_00565	COG0556	nucleotide-excision repair
amad1_00575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_00580	COG0842	Transport permease protein
amad1_00580	COG1129	ABC transporter
amad1_00585	COG0842	Transport permease protein
amad1_00600	COG1960	acyl-CoA dehydrogenase activity
amad1_00605	COG0583	DNA-binding transcription factor activity
amad1_00615	COG3106	COG3106 Predicted ATPase
amad1_00635	COG2184	nucleotidyltransferase activity
amad1_00640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
amad1_00655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
amad1_00660	COG0352	thiamine-phosphate diphosphorylase activity
amad1_00670	COG3071	HemY protein
amad1_00675	COG2959	enzyme of heme biosynthesis
amad1_00685	COG0181	hydroxymethylbilane synthase activity
amad1_00705	COG0194	GDP metabolic process
amad1_00715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
amad1_00725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
amad1_00730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
amad1_00740	COG0678	peroxiredoxin activity
amad1_00760	COG1178	ABC-type Fe3 transport system permease component
amad1_00765	COG3842	ATPase activity
amad1_00770	COG0668	transmembrane transport
amad1_00775	COG2081	HI0933 family
amad1_00795	COG2963	transposase activity
amad1_00830	COG0789	Transcriptional regulator
amad1_00835	COG2963	transposase activity
amad1_00840	COG2801	Transposase and inactivated derivatives
amad1_00855	COG2200	EAL domain
amad1_00860	COG0583	DNA-binding transcription factor activity
amad1_00870	COG2076	Multidrug Resistance protein
amad1_00885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_00900	COG0427	acetyl-CoA hydrolase
amad1_00905	COG0123	including yeast histone deacetylase and acetoin utilization protein
amad1_00920	COG0840	transmembrane signaling receptor activity
amad1_00930	COG3064	Membrane
amad1_00940	COG5002	protein histidine kinase activity
amad1_00940	COG5001	Diguanylate cyclase
amad1_00955	COG0514	ATP-dependent DNA helicase (RecQ)
amad1_00960	COG2239	Acts as a magnesium transporter
amad1_00965	COG2962	Rard protein
amad1_00970	COG0745	RESPONSE REGULATOR receiver
amad1_00970	COG3706	GGDEF domain
amad1_00975	COG0210	DNA helicase
amad1_00985	COG1011	Hydrolase
amad1_01000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
amad1_01005	COG0019	diaminopimelate decarboxylase activity
amad1_01035	COG0163	prenyltransferase activity
amad1_01040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
amad1_01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
amad1_01070	COG1077	Cell shape determining protein MreB Mrl
amad1_01080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
amad1_01085	COG2814	Major facilitator Superfamily
amad1_01090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
amad1_01120	COG1085	galactose-1-phosphate uridylyltransferase
amad1_01125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
amad1_01135	COG0629	single-stranded DNA binding
amad1_01150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
amad1_01155	COG3250	beta-galactosidase activity
amad1_01175	COG1349	DNA-binding transcription factor activity
amad1_01225	COG3409	Peptidoglycan-binding domain 1 protein
amad1_01225	COG3267	Type II secretory pathway component ExeA
amad1_01240	COG1459	type II secretion system
amad1_01285	COG1077	Cell shape determining protein MreB Mrl
amad1_01290	COG1792	Involved in formation and maintenance of cell shape
amad1_01295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
amad1_01305	COG1530	ribonuclease E activity
amad1_01315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
amad1_01320	COG0312	modulator of DNA gyrase
amad1_01325	COG3028	Belongs to the UPF0307 family
amad1_01330	COG0312	modulator of DNA gyrase
amad1_01340	COG0745	RESPONSE REGULATOR receiver
amad1_01345	COG4191	Histidine kinase
amad1_01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
amad1_01350	COG0297	glycogen (starch) synthase activity
amad1_01360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
amad1_01365	COG0596	Alpha beta hydrolase
amad1_01385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
amad1_01390	COG5002	protein histidine kinase activity
amad1_01395	COG0745	RESPONSE REGULATOR receiver
amad1_01415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
amad1_01515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
amad1_01545	COG0375	protein maturation
amad1_01555	COG0409	Hydrogenase expression formation protein
amad1_01565	COG0309	Hydrogenase expression formation protein (HypE)
amad1_01570	COG0789	Transcriptional regulator
amad1_01575	COG2217	Heavy metal translocating P-type atpase
amad1_01665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
amad1_01675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
amad1_01685	COG0463	Glycosyl transferase, family 2
amad1_01690	COG0745	RESPONSE REGULATOR receiver
amad1_01695	COG5002	protein histidine kinase activity
amad1_01725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
amad1_01735	COG0789	Transcriptional regulator
amad1_01740	COG2217	Heavy metal translocating P-type atpase
amad1_01780	COG0531	amino acid
amad1_01790	COG2132	Multicopper oxidase
amad1_01850	COG2801	Transposase and inactivated derivatives
amad1_01905	COG0546	phosphoglycolate phosphatase activity
amad1_01930	COG1609	Transcriptional regulator
amad1_01935	COG0673	inositol 2-dehydrogenase activity
amad1_01945	COG2211	Major facilitator Superfamily
amad1_01970	COG1454	alcohol dehydrogenase
amad1_02020	COG0089	rRNA binding
amad1_02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
amad1_02040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
amad1_02055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
amad1_02060	COG0438	transferase activity, transferring glycosyl groups
amad1_02070	COG1519	Transferase
amad1_02105	COG0788	formyltetrahydrofolate deformylase activity
amad1_02115	COG1643	Atp-dependent helicase
amad1_02120	COG2951	lytic endotransglycosylase activity
amad1_02125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
amad1_02140	COG2354	Protein conserved in bacteria
amad1_02145	COG4977	sequence-specific DNA binding
amad1_02160	COG0004	ammonium transporteR
amad1_02165	COG0405	Gamma-glutamyltransferase
amad1_02170	COG2837	iron assimilation
amad1_02185	COG0540	Belongs to the ATCase OTCase family
amad1_02210	COG0784	Response regulator, receiver
amad1_02210	COG2205	protein histidine kinase activity
amad1_02210	COG5002	protein histidine kinase activity
amad1_02225	COG3300	MHYT domain
amad1_02225	COG5001	Diguanylate cyclase
amad1_02235	COG1012	belongs to the aldehyde dehydrogenase family
amad1_02245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
amad1_02260	COG0180	Tryptophanyl-tRNA synthetase
amad1_02265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
amad1_02285	COG0338	D12 class N6 adenine-specific DNA methyltransferase
amad1_02295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
amad1_02330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
amad1_02335	COG0281	malic enzyme
amad1_02350	COG0625	glutathione transferase activity
amad1_02360	COG0753	catalase activity
amad1_02375	COG5001	Diguanylate cyclase
amad1_02375	COG3300	MHYT domain
amad1_02385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
amad1_02385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
amad1_02395	COG0137	argininosuccinate synthase activity
amad1_02415	COG1803	Methylglyoxal synthase
amad1_02425	COG0745	RESPONSE REGULATOR receiver
amad1_02430	COG2205	protein histidine kinase activity
amad1_02435	COG2267	carboxylic ester hydrolase activity
amad1_02440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
amad1_02450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
amad1_02460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
amad1_02465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
amad1_02470	COG4942	peptidase
amad1_02475	COG2861	carbohydrate metabolic process
amad1_02500	COG1162	GTPase activity
amad1_02505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
amad1_02530	COG0028	Belongs to the TPP enzyme family
amad1_02550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
amad1_02555	COG0805	protein transport
amad1_02565	COG0084	hydrolase, TatD family'
amad1_02570	COG4251	negative regulation of phosphorylation
amad1_02570	COG3706	GGDEF domain
amad1_02570	COG2203	Gaf domain
amad1_02570	COG5001	Diguanylate cyclase
amad1_02580	COG0248	Ppx GppA phosphatase
amad1_02585	COG0513	Belongs to the DEAD box helicase family
amad1_02590	COG3118	belongs to the thioredoxin family
amad1_02595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
amad1_02605	COG0784	Response regulator, receiver
amad1_02605	COG5002	protein histidine kinase activity
amad1_02610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
amad1_02620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
amad1_02630	COG0783	Belongs to the Dps family
amad1_02635	COG2133	pyrroloquinoline quinone binding
amad1_02640	COG4946	Tricorn protease homolog
amad1_02640	COG1506	peptidase
amad1_02640	COG0823	Involved in the tonB-independent uptake of proteins
amad1_02650	COG3118	belongs to the thioredoxin family
amad1_02665	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
amad1_02675	COG1012	belongs to the aldehyde dehydrogenase family
amad1_02695	COG1757	Na H antiporter
amad1_02710	COG3876	Protein conserved in bacteria
amad1_02715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
amad1_02725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
amad1_02735	COG0346	lactoylglutathione lyase activity
amad1_02760	COG2824	Alkylphosphonate utilization operon protein PhnA
amad1_02765	COG0454	-acetyltransferase
amad1_02795	COG3093	addiction module antidote protein HigA
amad1_02810	COG2026	Addiction module toxin, RelE StbE family
amad1_02835	COG3547	Transposase (IS116 IS110 IS902 family)
amad1_02880	COG2801	Transposase and inactivated derivatives
amad1_02890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
amad1_02895	COG1620	l-lactate permease
amad1_02910	COG0514	ATP-dependent DNA helicase (RecQ)
amad1_02935	COG0183	Belongs to the thiolase family
amad1_02940	COG1024	Enoyl-CoA hydratase
amad1_02940	COG1250	3-hydroxyacyl-CoA dehydrogenase
amad1_02950	COG0006	proline dipeptidase activity
amad1_02960	COG0142	geranyltranstransferase activity
amad1_02990	COG4942	peptidase
amad1_02990	COG1388	LysM domain
amad1_02995	COG1238	metal cluster binding
amad1_03005	COG0585	pseudouridine synthase activity
amad1_03010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
amad1_03020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
amad1_03030	COG0840	transmembrane signaling receptor activity
amad1_03070	COG0494	nUDIX hydrolase
amad1_03075	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
amad1_03080	COG0730	response to heat
amad1_03085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
amad1_03090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
amad1_03100	COG0745	RESPONSE REGULATOR receiver
amad1_03100	COG3706	GGDEF domain
amad1_03125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
amad1_03140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
amad1_03150	COG1648	precorrin-2 dehydrogenase activity
amad1_03150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
amad1_03155	COG0513	Belongs to the DEAD box helicase family
amad1_03175	COG1538	Outer membrane efflux protein
amad1_03180	COG0494	nUDIX hydrolase
amad1_03190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
amad1_03195	COG3150	esterase
amad1_03200	COG0187	DNA topoisomerase II activity
amad1_03210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
amad1_03235	COG1509	lysine 2,3-aminomutase activity
amad1_03245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
amad1_03260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
amad1_03275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
amad1_03290	COG0271	Belongs to the BolA IbaG family
amad1_03310	COG3707	response regulator
amad1_03320	COG0659	secondary active sulfate transmembrane transporter activity
amad1_03325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
amad1_03335	COG0243	molybdopterin cofactor binding
amad1_03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
amad1_03340	COG1648	precorrin-2 dehydrogenase activity
amad1_03345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
amad1_03355	COG1116	anion transmembrane transporter activity
amad1_03355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
amad1_03365	COG1116	anion transmembrane transporter activity
amad1_03380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
amad1_03385	COG4206	TonB-dependent receptor
amad1_03395	COG0348	domain, Protein
amad1_03410	COG1960	acyl-CoA dehydrogenase activity
amad1_03415	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_03425	COG4948	Mandelate Racemase Muconate Lactonizing
amad1_03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_03445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
amad1_03465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
amad1_03470	COG0358	DNA primase activity
amad1_03500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
amad1_03505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
amad1_03520	COG0537	adenosine 5'-monophosphoramidase activity
amad1_03535	COG3135	benzoate transporter
amad1_03540	COG1396	sequence-specific DNA binding
amad1_03545	COG2974	May be involved in recombination
amad1_03550	COG4191	Histidine kinase
amad1_03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
amad1_03555	COG0745	RESPONSE REGULATOR receiver
amad1_03560	COG5002	protein histidine kinase activity
amad1_03585	COG0811	peptide transport
amad1_03590	COG0811	peptide transport
amad1_03595	COG0848	biopolymer transport protein
amad1_03600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
amad1_03610	COG3437	response regulator, receiver
amad1_03620	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_03630	COG2133	pyrroloquinoline quinone binding
amad1_03640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
amad1_03665	COG0527	aspartate kinase activity
amad1_03670	COG0840	transmembrane signaling receptor activity
amad1_03675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
amad1_03680	COG2967	ApaG domain
amad1_03690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
amad1_03695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
amad1_03700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
amad1_03705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
amad1_03715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
amad1_03735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
amad1_03750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
amad1_03755	COG3956	TIGRFAM MazG family protein
amad1_03780	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_03790	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_03800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
amad1_03810	COG0463	Glycosyl transferase, family 2
amad1_03830	COG0642	Histidine kinase
amad1_03835	COG0745	RESPONSE REGULATOR receiver
amad1_03850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
amad1_03855	COG0723	plastoquinol--plastocyanin reductase activity
amad1_03860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
amad1_03865	COG2857	Cytochrome c1
amad1_03870	COG0625	glutathione transferase activity
amad1_03875	COG2969	positive regulation of protein catabolic process
amad1_03880	COG2239	Acts as a magnesium transporter
amad1_03885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
amad1_03895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
amad1_03905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
amad1_03910	COG1137	ATPase activity
amad1_03915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
amad1_03925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
amad1_03940	COG1127	ABC transporter
amad1_03945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
amad1_03950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
amad1_03955	COG2854	intermembrane phospholipid transfer
amad1_03965	COG5007	Belongs to the BolA IbaG family
amad1_03975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
amad1_03980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
amad1_03990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
amad1_04025	COG4771	TonB-dependent receptor
amad1_04030	COG0697	spore germination
amad1_04040	COG0784	Response regulator, receiver
amad1_04040	COG2205	protein histidine kinase activity
amad1_04065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
amad1_04075	COG0126	phosphoglycerate kinase activity
amad1_04080	COG3588	fructose-bisphosphate aldolase
amad1_04090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_04100	COG1538	Outer membrane efflux protein
amad1_04105	COG0823	Involved in the tonB-independent uptake of proteins
amad1_04105	COG1506	peptidase
amad1_04105	COG4946	Tricorn protease homolog
amad1_04110	COG0248	Ppx GppA phosphatase
amad1_04115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
amad1_04125	COG0573	inorganic phosphate transmembrane transporter activity
amad1_04135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
amad1_04145	COG0306	phosphate transporter
amad1_04155	COG0583	DNA-binding transcription factor activity
amad1_04165	COG1272	protein, Hemolysin III
amad1_04170	COG1846	Transcriptional regulator
amad1_04175	COG1764	response to oxidative stress
amad1_04190	COG1739	Uncharacterized protein family UPF0029
amad1_04210	COG0420	3'-5' exonuclease activity
amad1_04215	COG0419	ATPase involved in DNA repair
amad1_04230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
amad1_04245	COG2188	Transcriptional regulator
amad1_04255	COG2986	histidine ammonia-lyase
amad1_04285	COG0488	(ABC) transporter
amad1_04310	COG0668	transmembrane transport
amad1_04330	COG2801	Transposase and inactivated derivatives
amad1_04355	COG0582	viral genome integration into host DNA
amad1_04360	COG4372	Transposase
amad1_04410	COG1484	DNA-dependent DNA replication
amad1_04420	COG2801	Transposase and inactivated derivatives
amad1_04430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
amad1_04445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
amad1_04490	COG1346	cytolysis
amad1_04520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
amad1_04530	COG0513	Belongs to the DEAD box helicase family
amad1_04540	COG3409	Peptidoglycan-binding domain 1 protein
amad1_04540	COG3267	Type II secretory pathway component ExeA
amad1_04555	COG0066	3-isopropylmalate dehydratase activity
amad1_04565	COG0473	3-isopropylmalate dehydrogenase activity
amad1_04570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
amad1_04590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
amad1_04605	COG4555	ABC transporter
amad1_04610	COG1668	transmembrane transport
amad1_04630	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
amad1_04635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
amad1_04640	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
amad1_04650	COG1138	Cytochrome C-type biogenesis protein
amad1_04655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
amad1_04670	COG2853	Lipoprotein
amad1_04675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
amad1_04685	COG3104	oligopeptide transport
amad1_04715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
amad1_04730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
amad1_04735	COG1555	photosystem II stabilization
amad1_04735	COG1596	polysaccharide export
amad1_04740	COG0473	3-isopropylmalate dehydrogenase activity
amad1_04755	COG1611	Belongs to the LOG family
amad1_04760	COG3706	GGDEF domain
amad1_04760	COG0745	RESPONSE REGULATOR receiver
amad1_04765	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
amad1_04765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
amad1_04820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
amad1_04825	COG0024	Methionine aminopeptidase
amad1_04830	COG0052	Belongs to the universal ribosomal protein uS2 family
amad1_04840	COG0528	UMP kinase activity
amad1_04850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
amad1_04855	COG0575	Belongs to the CDS family
amad1_04880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
amad1_04900	COG0587	DNA-directed DNA polymerase activity
amad1_04905	COG0825	malonyl-CoA metabolic process
amad1_04910	COG0037	tRNA processing
amad1_04930	COG0590	tRNA wobble adenosine to inosine editing
amad1_04945	COG0047	phosphoribosylformylglycinamidine synthase activity
amad1_04945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
amad1_04955	COG2840	Smr protein MutS2
amad1_04990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_04995	COG2197	response regulator
amad1_05035	COG0835	chemotaxis
amad1_05035	COG0784	Response regulator, receiver
amad1_05040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
amad1_05045	COG1815	bacterial-type flagellum-dependent cell motility
amad1_05050	COG1558	bacterial-type flagellum-dependent cell motility
amad1_05055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
amad1_05060	COG1749	Flagellar hook protein flgE
amad1_05065	COG4787	bacterial-type flagellum-dependent cell motility
amad1_05070	COG4786	Flagellar basal body rod
amad1_05085	COG1705	Flagellar rod assembly protein muramidase FlgJ
amad1_05085	COG3951	Flagellar rod assembly protein muramidase FlgJ
amad1_05090	COG1256	bacterial-type flagellum assembly
amad1_05105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
amad1_05110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
amad1_05115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
amad1_05120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
amad1_05135	COG1516	flagellar protein fliS
amad1_05150	COG1086	Polysaccharide biosynthesis protein
amad1_05155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
amad1_05165	COG2089	acid synthase
amad1_05180	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_05185	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_05230	COG1660	Displays ATPase and GTPase activities
amad1_05235	COG1216	Glycosyl transferase, family 2
amad1_05250	COG1083	cytidylyl-transferase
amad1_05260	COG2204	response regulator
amad1_05265	COG3852	Histidine kinase
amad1_05270	COG2204	response regulator
amad1_05275	COG1677	Flagellar hook-basal body complex protein FliE
amad1_05280	COG1766	The M ring may be actively involved in energy transduction
amad1_05285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
amad1_05335	COG1987	bacterial-type flagellum assembly
amad1_05350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
amad1_05360	COG0455	bacterial-type flagellum organization
amad1_05375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
amad1_05380	COG0643	Histidine kinase
amad1_05380	COG2198	Histidine kinase
amad1_05390	COG1192	Involved in chromosome partitioning
amad1_05400	COG0835	chemotaxis
amad1_05415	COG1410	methionine synthase
amad1_05415	COG0646	methionine synthase
amad1_05420	COG0646	methionine synthase
amad1_05420	COG1410	methionine synthase
amad1_05430	COG3123	guanosine phosphorylase activity
amad1_05435	COG0583	DNA-binding transcription factor activity
amad1_05440	COG0583	DNA-binding transcription factor activity
amad1_05450	COG0659	secondary active sulfate transmembrane transporter activity
amad1_05465	COG3590	peptidase
amad1_05475	COG2137	regulation of response to DNA damage stimulus
amad1_05480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
amad1_05495	COG0511	ligase activity, forming carbon-carbon bonds
amad1_05495	COG5016	pyruvate
amad1_05500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
amad1_05505	COG4172	Belongs to the ABC transporter superfamily
amad1_05515	COG4171	peptide transport system, permease
amad1_05520	COG4168	peptide transport system, permease
amad1_05525	COG0747	negative chemotaxis
amad1_05530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
amad1_05535	COG1842	Phage shock protein A
amad1_05565	COG0625	glutathione transferase activity
amad1_05570	COG1522	sequence-specific DNA binding
amad1_05640	COG0811	peptide transport
amad1_05645	COG0811	peptide transport
amad1_05650	COG0848	biopolymer transport protein
amad1_05665	COG1444	tRNA N-acetyltransferase activity
amad1_05700	COG0456	acetyltransferase
amad1_05715	COG0583	DNA-binding transcription factor activity
amad1_05720	COG2814	Major facilitator Superfamily
amad1_05725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
amad1_05730	COG0656	L-ascorbic acid biosynthetic process
amad1_05750	COG1846	Transcriptional regulator
amad1_05760	COG3620	sequence-specific DNA binding
amad1_05765	COG3550	peptidyl-serine autophosphorylation
amad1_05795	COG0668	transmembrane transport
amad1_05805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
amad1_05825	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
amad1_05945	COG0789	Transcriptional regulator
amad1_05965	COG0789	Transcriptional regulator
amad1_05970	COG0640	Transcriptional regulator
amad1_05975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_05980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_05980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_05985	COG1230	cation diffusion facilitator family transporter
amad1_06020	COG1538	Outer membrane efflux protein
amad1_06035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
amad1_06055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
amad1_06070	COG0681	Belongs to the peptidase S26 family
amad1_06090	COG1074	ATP-dependent DNA helicase activity
amad1_06100	COG1404	Belongs to the peptidase S8 family
amad1_06105	COG0464	growth
amad1_06125	COG0629	single-stranded DNA binding
amad1_06145	COG0714	Associated with various cellular activities
amad1_06170	COG2003	Belongs to the UPF0758 family
amad1_06190	COG0583	DNA-binding transcription factor activity
amad1_06280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
amad1_06290	COG3706	GGDEF domain
amad1_06325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
amad1_06330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
amad1_06335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
amad1_06340	COG0564	pseudouridine synthase activity
amad1_06350	COG0612	Peptidase, M16
amad1_06355	COG2918	glutathione biosynthetic process
amad1_06380	COG2840	Smr protein MutS2
amad1_06385	COG2890	protein-(glutamine-N5) methyltransferase activity
amad1_06400	COG2719	SpoVR family
amad1_06405	COG2718	Belongs to the UPF0229 family
amad1_06410	COG2766	serine protein kinase
amad1_06420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
amad1_06425	COG4771	TonB-dependent receptor
amad1_06450	COG0450	alkyl hydroperoxide reductase
amad1_06455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
amad1_06460	COG2885	chlorophyll binding
amad1_06465	COG0584	glycerophosphoryl diester phosphodiesterase
amad1_06470	COG0346	lactoylglutathione lyase activity
amad1_06475	COG1278	Cold shock
amad1_06490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
amad1_06495	COG4660	Part of a membrane complex involved in electron transport
amad1_06500	COG4659	FMN binding
amad1_06505	COG4658	electron transport chain
amad1_06520	COG2878	Part of a membrane complex involved in electron transport
amad1_06530	COG0534	Mate efflux family protein
amad1_06535	COG0556	nucleotide-excision repair
amad1_06550	COG0602	queuosine metabolic process
amad1_06560	COG0367	asparagine synthase
amad1_06585	COG0471	metal ion transport
amad1_06585	COG3273	potassium ion transport
amad1_06600	COG0529	Catalyzes the synthesis of activated sulfate
amad1_06605	COG0175	sulfate reduction
amad1_06610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
amad1_06615	COG3706	GGDEF domain
amad1_06640	COG2304	oxidoreductase activity
amad1_06660	COG0714	Associated with various cellular activities
amad1_06670	COG1024	Enoyl-CoA hydratase
amad1_06670	COG1250	3-hydroxyacyl-CoA dehydrogenase
amad1_06690	COG1025	Belongs to the peptidase M16 family
amad1_06695	COG2062	phosphohistidine phosphatase, SixA
amad1_06705	COG4536	flavin adenine dinucleotide binding
amad1_06710	COG4137	Cytochrome C assembly protein
amad1_06715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
amad1_06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_06765	COG1132	(ABC) transporter
amad1_06780	COG0228	four-way junction DNA binding
amad1_06785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
amad1_06790	COG0336	Belongs to the RNA methyltransferase TrmD family
amad1_06795	COG0335	large ribosomal subunit rRNA binding
amad1_06800	COG2860	membrane
amad1_06810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
amad1_06815	COG1605	Chorismate mutase
amad1_06815	COG0287	Prephenate dehydrogenase
amad1_06820	COG1605	Chorismate mutase
amad1_06820	COG0077	Prephenate dehydratase
amad1_06830	COG0023	Translation Initiation Factor
amad1_06860	COG2205	protein histidine kinase activity
amad1_06870	COG2204	response regulator
amad1_06895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
amad1_06900	COG0494	nUDIX hydrolase
amad1_06905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
amad1_06915	COG2255	four-way junction helicase activity
amad1_06920	COG0824	Thioesterase
amad1_06925	COG0811	peptide transport
amad1_06940	COG0823	Involved in the tonB-independent uptake of proteins
amad1_06945	COG2885	chlorophyll binding
amad1_06950	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
amad1_06960	COG3344	reverse transcriptase
amad1_06965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
amad1_06980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
amad1_06995	COG4667	esterase of the alpha-beta hydrolase superfamily
amad1_07000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
amad1_07010	COG0784	Response regulator, receiver
amad1_07010	COG2205	protein histidine kinase activity
amad1_07030	COG3038	cytochrome b561
amad1_07050	COG0583	DNA-binding transcription factor activity
amad1_07055	COG1451	nucleotide metabolic process
amad1_07065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
amad1_07075	COG1309	transcriptional regulator
amad1_07080	COG4774	siderophore transport
amad1_07100	COG3706	GGDEF domain
amad1_07110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
amad1_07110	COG3008	intermembrane lipid transfer
amad1_07115	COG2995	paraquat-inducible protein a
amad1_07130	COG0017	Asparaginyl-tRNA synthetase
amad1_07145	COG0189	ligase activity
amad1_07175	COG0156	8-amino-7-oxononanoate synthase activity
amad1_07180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
amad1_07190	COG3340	Belongs to the peptidase S51 family
amad1_07195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
amad1_07200	COG4139	cobalamin transport
amad1_07205	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
amad1_07210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
amad1_07225	COG5265	(ABC) transporter
amad1_07230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
amad1_07240	COG0745	RESPONSE REGULATOR receiver
amad1_07245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
amad1_07265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
amad1_07280	COG2755	lipolytic protein G-D-S-L family
amad1_07285	COG4181	ATPase activity
amad1_07290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
amad1_07295	COG1090	epimerase
amad1_07300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
amad1_07305	COG0628	permease
amad1_07315	COG0745	RESPONSE REGULATOR receiver
amad1_07330	COG2350	Protein conserved in bacteria
amad1_07335	COG0159	tryptophan synthase activity
amad1_07345	COG0135	phosphoribosylanthranilate isomerase activity
amad1_07345	COG0134	indole-3-glycerol-phosphate synthase activity
amad1_07350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
amad1_07360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
amad1_07365	COG0613	PHP domain protein
amad1_07370	COG0009	L-threonylcarbamoyladenylate synthase
amad1_07375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
amad1_07380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
amad1_07390	COG0656	L-ascorbic acid biosynthetic process
amad1_07395	COG0110	maltose O-acetyltransferase activity
amad1_07405	COG2733	membrane
amad1_07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_07430	COG0500	methyltransferase
amad1_07435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
amad1_07440	COG0497	DNA recombination
amad1_07445	COG0783	Belongs to the Dps family
amad1_07455	COG1454	alcohol dehydrogenase
amad1_07460	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_07470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
amad1_07475	COG2610	gluconate transmembrane transporter activity
amad1_07480	COG4771	TonB-dependent receptor
amad1_07490	COG2198	Histidine kinase
amad1_07490	COG0784	Response regulator, receiver
amad1_07490	COG2205	protein histidine kinase activity
amad1_07495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
amad1_07505	COG0484	heat shock protein binding
amad1_07510	COG3909	cytochrome
amad1_07515	COG4943	cyclic-guanylate-specific phosphodiesterase activity
amad1_07530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
amad1_07535	COG0505	Belongs to the CarA family
amad1_07540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
amad1_07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
amad1_07565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
amad1_07570	COG0857	belongs to the CobB CobQ family
amad1_07570	COG0280	phosphate acetyltransferase
amad1_07585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
amad1_07590	COG4535	Mg2 and Co2 transporter CorC
amad1_07600	COG1702	phosphate starvation-inducible protein PhoH
amad1_07610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
amad1_07655	COG1607	acyl-coa hydrolase
amad1_07660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
amad1_07670	COG1115	amino acid carrier protein
amad1_07675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
amad1_07680	COG0012	GTP binding
amad1_07700	COG1064	alcohol dehydrogenase
amad1_07715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
amad1_07720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
amad1_07725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
amad1_07730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
amad1_07740	COG2890	protein-(glutamine-N5) methyltransferase activity
amad1_07745	COG0784	Response regulator, receiver
amad1_07745	COG3437	response regulator, receiver
amad1_07750	COG3094	Invasion gene expression up-regulator, SirB
amad1_07765	COG0583	DNA-binding transcription factor activity
amad1_07775	COG2363	Small membrane protein
amad1_07790	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
amad1_07795	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
amad1_07800	COG0515	serine threonine protein kinase
amad1_07805	COG2116	formate transmembrane transporter activity
amad1_07820	COG0714	Associated with various cellular activities
amad1_07825	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
amad1_07830	COG0033	Phosphoglucomutase
amad1_07835	COG0058	SHG alpha-glucan phosphorylase activity
amad1_07845	COG2988	succinylglutamate desuccinylase activity
amad1_07880	COG1393	Belongs to the ArsC family
amad1_07905	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
amad1_07935	COG5001	Diguanylate cyclase
amad1_07935	COG3300	MHYT domain
amad1_07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
amad1_07980	COG1733	regulation of RNA biosynthetic process
amad1_07985	COG5001	Diguanylate cyclase
amad1_07985	COG5002	protein histidine kinase activity
amad1_07985	COG3447	MASE1 domain protein
amad1_07995	COG0402	S-adenosylhomocysteine deaminase activity
amad1_08000	COG2351	hydroxyisourate hydrolase activity
amad1_08015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
amad1_08030	COG1309	transcriptional regulator
amad1_08045	COG2252	PERMEase
amad1_08050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
amad1_08065	COG3706	GGDEF domain
amad1_08065	COG4251	negative regulation of phosphorylation
amad1_08065	COG5001	Diguanylate cyclase
amad1_08065	COG2203	Gaf domain
amad1_08070	COG4251	negative regulation of phosphorylation
amad1_08070	COG5001	Diguanylate cyclase
amad1_08070	COG3706	GGDEF domain
amad1_08070	COG2203	Gaf domain
amad1_08075	COG2205	protein histidine kinase activity
amad1_08075	COG0784	Response regulator, receiver
amad1_08090	COG2233	PERMEase
amad1_08105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
amad1_08110	COG0730	response to heat
amad1_08155	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_08170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
amad1_08185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
amad1_08185	COG0662	Cupin 2, conserved barrel domain protein
amad1_08190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
amad1_08200	COG1596	polysaccharide export
amad1_08205	COG0489	protein tyrosine kinase activity
amad1_08210	COG4464	protein tyrosine phosphatase activity
amad1_08265	COG1216	Glycosyl transferase, family 2
amad1_08280	COG1215	transferase activity, transferring glycosyl groups
amad1_08285	COG0438	transferase activity, transferring glycosyl groups
amad1_08295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
amad1_08315	COG0072	phenylalanine-tRNA ligase activity
amad1_08315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
amad1_08330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
amad1_08340	COG1472	Belongs to the glycosyl hydrolase 3 family
amad1_08345	COG2096	Adenosyltransferase
amad1_08355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
amad1_08365	COG4591	ABC-type transport system involved in lipoprotein release permease component
amad1_08390	COG0708	Exodeoxyribonuclease III
amad1_08425	COG2814	Major facilitator Superfamily
amad1_08470	COG1024	Enoyl-CoA hydratase
amad1_08475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
amad1_08480	COG1960	acyl-CoA dehydrogenase activity
amad1_08485	COG0789	Transcriptional regulator
amad1_08490	COG0183	Belongs to the thiolase family
amad1_08505	COG3706	GGDEF domain
amad1_08515	COG2925	Exonuclease
amad1_08520	COG0582	viral genome integration into host DNA
amad1_08560	COG1674	ftsk spoiiie
amad1_08560	COG0531	amino acid
amad1_08605	COG2197	response regulator
amad1_08620	COG3617	BRO family, N-terminal domain
amad1_08690	COG0305	Participates in initiation and elongation during chromosome replication
amad1_08780	COG3728	DNA packaging
amad1_08780	COG5484	DNA packaging
amad1_08930	COG1643	Atp-dependent helicase
amad1_08950	COG0604	alcohol dehydrogenase
amad1_08950	COG3321	synthase
amad1_08955	COG0328	RNA-DNA hybrid ribonuclease activity
amad1_08960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
amad1_08970	COG4943	cyclic-guanylate-specific phosphodiesterase activity
amad1_08980	COG4591	ABC-type transport system involved in lipoprotein release permease component
amad1_08995	COG3724	N-succinylarginine dihydrolase activity
amad1_09025	COG0746	molybdenum cofactor guanylyltransferase activity
amad1_09030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
amad1_09035	COG0243	molybdopterin cofactor binding
amad1_09040	COG2153	protein acetylation
amad1_09055	COG1530	ribonuclease E activity
amad1_09070	COG0424	maF-like protein
amad1_09075	COG1399	metal-binding, possibly nucleic acid-binding protein
amad1_09085	COG0416	fatty acid biosynthetic process
amad1_09090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
amad1_09095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
amad1_09105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
amad1_09110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
amad1_09120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
amad1_09135	COG0084	hydrolase, TatD family'
amad1_09145	COG0702	epimerase
amad1_09150	COG0745	RESPONSE REGULATOR receiver
amad1_09150	COG3706	GGDEF domain
amad1_09170	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_09175	COG0596	Alpha beta hydrolase
amad1_09185	COG0183	Belongs to the thiolase family
amad1_09190	COG1960	acyl-CoA dehydrogenase activity
amad1_09210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
amad1_09220	COG0246	Mannitol dehydrogenase
amad1_09245	COG0668	transmembrane transport
amad1_09250	COG4771	TonB-dependent receptor
amad1_09265	COG3437	response regulator, receiver
amad1_09275	COG0195	Participates in both transcription termination and antitermination
amad1_09290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
amad1_09305	COG1187	pseudouridine synthase activity
amad1_09320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
amad1_09320	COG3153	acetyltransferase
amad1_09360	COG0450	alkyl hydroperoxide reductase
amad1_09405	COG1032	radical SAM domain protein
amad1_09420	COG4771	TonB-dependent receptor
amad1_09425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_09435	COG4134	Bacterial extracellular solute-binding protein
amad1_09445	COG4136	ATPase activity
amad1_09450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
amad1_09475	COG3706	GGDEF domain
amad1_09475	COG2203	Gaf domain
amad1_09475	COG5001	Diguanylate cyclase
amad1_09475	COG4251	negative regulation of phosphorylation
amad1_09510	COG4372	Transposase
amad1_09520	COG1902	pentaerythritol trinitrate reductase activity
amad1_09530	COG2867	negative regulation of translational initiation
amad1_09535	COG2914	Belongs to the UPF0125 (RnfH) family
amad1_09545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
amad1_09550	COG4771	TonB-dependent receptor
amad1_09560	COG0457	Tetratricopeptide repeat
amad1_09575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
amad1_09575	COG0574	Belongs to the PEP-utilizing enzyme family
amad1_09615	COG2850	peptidyl-arginine hydroxylation
amad1_09625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
amad1_09630	COG2915	High frequency lysogenization protein hflD homolog
amad1_09635	COG0482	sulfurtransferase activity
amad1_09640	COG1187	pseudouridine synthase activity
amad1_09650	COG1278	Cold shock
amad1_09655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
amad1_09660	COG0542	response to heat
amad1_09665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
amad1_09670	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
amad1_09675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
amad1_09680	COG0492	ferredoxin-NADP+ reductase activity
amad1_09685	COG3092	negative regulation of chromosome organization
amad1_09690	COG3091	SprT-like family
amad1_09695	COG0616	signal peptide processing
amad1_09710	COG0778	Nitroreductase
amad1_09720	COG0252	asparaginase activity
amad1_09725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
amad1_09730	COG0321	lipoyl(octanoyl) transferase activity
amad1_09735	COG2921	Belongs to the UPF0250 family
amad1_09740	COG1686	Belongs to the peptidase S11 family
amad1_09745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
amad1_09750	COG0772	Belongs to the SEDS family
amad1_09755	COG0768	penicillin binding
amad1_09760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
amad1_09765	COG0799	negative regulation of ribosome biogenesis
amad1_09775	COG1466	dna polymerase III delta subunit
amad1_09780	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
amad1_09785	COG0495	leucyl-tRNA aminoacylation
amad1_09800	COG1067	ATP-dependent peptidase activity
amad1_09805	COG0596	Alpha beta hydrolase
amad1_09810	COG3706	GGDEF domain
amad1_09820	COG1534	Rna-binding protein
amad1_09825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
amad1_09830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
amad1_09835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
amad1_09840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
amad1_09845	COG0149	triose-phosphate isomerase activity
amad1_09850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
amad1_09855	COG5001	Diguanylate cyclase
amad1_09855	COG3300	MHYT domain
amad1_09875	COG1597	lipid kinase activity
amad1_09875	COG1803	Methylglyoxal synthase
amad1_09885	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_09890	COG0561	phosphatase activity
amad1_09905	COG2801	Transposase and inactivated derivatives
amad1_09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
amad1_09940	COG1185	polyribonucleotide nucleotidyltransferase activity
amad1_09970	COG1819	glycosyl
amad1_10010	COG3547	Transposase (IS116 IS110 IS902 family)
amad1_10060	COG2801	Transposase and inactivated derivatives
amad1_10140	COG4372	Transposase
amad1_10175	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
amad1_10180	COG1196	nuclear chromosome segregation
amad1_10190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
amad1_10210	COG1132	(ABC) transporter
amad1_10215	COG1663	tetraacyldisaccharide 4'-kinase activity
amad1_10250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
amad1_10255	COG0435	Glutathione S-transferase
amad1_10260	COG1741	Belongs to the pirin family
amad1_10265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
amad1_10275	COG0372	Belongs to the citrate synthase family
amad1_10280	COG2009	succinate dehydrogenase
amad1_10285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
amad1_10290	COG1053	succinate dehydrogenase
amad1_10295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
amad1_10300	COG0567	Dehydrogenase, E1 component
amad1_10305	COG0508	dehydrogenase complex catalyzes the overall conversion of
amad1_10340	COG4667	esterase of the alpha-beta hydrolase superfamily
amad1_10360	COG0366	Alpha amylase catalytic
amad1_10385	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_10390	COG2267	carboxylic ester hydrolase activity
amad1_10400	COG0616	signal peptide processing
amad1_10420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
amad1_10425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
amad1_10430	COG0386	Belongs to the glutathione peroxidase family
amad1_10435	COG2084	Dehydrogenase
amad1_10445	COG1960	acyl-CoA dehydrogenase activity
amad1_10450	COG1024	Enoyl-CoA hydratase
amad1_10460	COG2226	methyltransferase
amad1_10465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
amad1_10470	COG3083	sulfuric ester hydrolase activity
amad1_10475	COG3082	Protein of unknown function (DUF1414)
amad1_10480	COG3081	Nucleoid-associated protein
amad1_10510	COG3275	phosphorelay sensor kinase activity
amad1_10515	COG3279	Response regulator of the LytR AlgR family
amad1_10520	COG0205	6-phosphofructokinase activity
amad1_10535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
amad1_10550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
amad1_10550	COG2205	protein histidine kinase activity
amad1_10570	COG0513	Belongs to the DEAD box helicase family
amad1_10580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
amad1_10585	COG0583	DNA-binding transcription factor activity
amad1_10605	COG1760	l-serine dehydratase
amad1_10630	COG1322	Protein conserved in bacteria
amad1_10635	COG1404	Belongs to the peptidase S8 family
amad1_10640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
amad1_10645	COG0022	dehydrogenase e1 component
amad1_10655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
amad1_10660	COG0515	serine threonine protein kinase
amad1_10665	COG1946	Acyl-CoA thioesterase
amad1_10675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
amad1_10685	COG1956	GAF domain-containing protein
amad1_10700	COG0793	Belongs to the peptidase S41A family
amad1_10705	COG0733	neurotransmitter:sodium symporter activity
amad1_10715	COG0308	aminopeptidase N
amad1_10745	COG2902	Dehydrogenase
amad1_10750	COG0167	dihydroorotate dehydrogenase activity
amad1_10775	COG3130	regulation of translation
amad1_10780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
amad1_10790	COG0415	Belongs to the DNA photolyase family
amad1_10795	COG0415	Belongs to the DNA photolyase family
amad1_10800	COG0415	Belongs to the DNA photolyase family
amad1_10805	COG3046	protein related to deoxyribodipyrimidine photolyase
amad1_10820	COG4974	Belongs to the 'phage' integrase family
amad1_10830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
amad1_10835	COG0589	response to stress
amad1_10845	COG0069	glutamate synthase activity
amad1_10860	COG2193	ferroxidase activity
amad1_10870	COG3278	Belongs to the heme-copper respiratory oxidase family
amad1_10885	COG2010	Cytochrome c
amad1_10910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
amad1_10915	COG0589	response to stress
amad1_10920	COG0037	tRNA processing
amad1_10925	COG1752	Esterase of the alpha-beta hydrolase superfamily
amad1_10945	COG1280	lysine exporter protein (LysE YggA)
amad1_10950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
amad1_10955	COG2897	thiosulfate sulfurtransferase activity
amad1_10960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
amad1_10975	COG0322	excinuclease ABC activity
amad1_10980	COG2197	response regulator
amad1_10985	COG0436	Aminotransferase
amad1_11000	COG2259	Doxx family
amad1_11005	COG0583	DNA-binding transcription factor activity
amad1_11020	COG0670	Belongs to the BI1 family
amad1_11025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
amad1_11040	COG2920	part of a sulfur-relay system
amad1_11070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
amad1_11080	COG0531	amino acid
amad1_11080	COG1674	ftsk spoiiie
amad1_11090	COG0686	Belongs to the AlaDH PNT family
amad1_11095	COG0284	orotidine-5'-phosphate decarboxylase activity
amad1_11100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
amad1_11115	COG0776	regulation of translation
amad1_11120	COG0539	negative regulation of cytoplasmic translation
amad1_11125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
amad1_11140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
amad1_11150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
amad1_11155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
amad1_11160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
amad1_11165	COG0633	Ferredoxin
amad1_11195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
amad1_11200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
amad1_11210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
amad1_11220	COG4783	chaperone-mediated protein folding
amad1_11230	COG1393	Belongs to the ArsC family
amad1_11245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
amad1_11260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
amad1_11270	COG1960	acyl-CoA dehydrogenase activity
amad1_11295	COG0572	uridine kinase
amad1_11300	COG3769	mannosylglycerate metabolic process
amad1_11305	COG1215	transferase activity, transferring glycosyl groups
amad1_11310	COG0366	Alpha amylase catalytic
amad1_11320	COG0303	'Molybdopterin
amad1_11325	COG0534	Mate efflux family protein
amad1_11340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
amad1_11345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
amad1_11375	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
amad1_11395	COG3547	Transposase (IS116 IS110 IS902 family)
amad1_11420	COG0405	Gamma-glutamyltransferase
amad1_11425	COG1024	Enoyl-CoA hydratase
amad1_11470	COG1448	Aminotransferase
amad1_11480	COG1671	Belongs to the UPF0178 family
amad1_11485	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_11490	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_11495	COG1960	acyl-CoA dehydrogenase activity
amad1_11500	COG2207	Transcriptional regulator
amad1_11500	COG0662	Cupin 2, conserved barrel domain protein
amad1_11515	COG3344	reverse transcriptase
amad1_11525	COG1505	serine-type exopeptidase activity
amad1_11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_11565	COG0596	Alpha beta hydrolase
amad1_11575	COG0716	FMN binding
amad1_11585	COG0735	belongs to the Fur family
amad1_11595	COG1984	allophanate hydrolase subunit 2
amad1_11600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
amad1_11605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
amad1_11610	COG2996	Protein conserved in bacteria
amad1_11615	COG1765	OsmC-like protein
amad1_11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_11630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
amad1_11645	COG0436	Aminotransferase
amad1_11650	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
amad1_11655	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
amad1_11665	COG2010	Cytochrome c
amad1_11665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
amad1_11670	COG2080	2 iron, 2 sulfur cluster binding
amad1_11695	COG1073	alpha beta
amad1_11700	COG2207	Transcriptional regulator
amad1_11710	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
amad1_11715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
amad1_11740	COG3012	SEC-C Motif Domain Protein
amad1_11750	COG0604	alcohol dehydrogenase
amad1_11760	COG1960	acyl-CoA dehydrogenase activity
amad1_11770	COG4771	TonB-dependent receptor
amad1_11790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
amad1_11795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
amad1_11815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
amad1_11820	COG0315	cyclic pyranopterin monophosphate synthase activity
amad1_11825	COG0521	Mo-molybdopterin cofactor biosynthetic process
amad1_11840	COG2161	toxin-antitoxin pair type II binding
amad1_11845	COG4115	mRNA cleavage
amad1_11860	COG0436	Aminotransferase
amad1_11865	COG3268	Saccharopine dehydrogenase
amad1_11870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
amad1_11885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
amad1_11890	COG4206	TonB-dependent receptor
amad1_11900	COG5006	permease, DMT superfamily
amad1_11915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
amad1_11920	COG1074	ATP-dependent DNA helicase activity
amad1_11925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
amad1_11945	COG1022	Amp-dependent synthetase and ligase
amad1_11950	COG5001	Diguanylate cyclase
amad1_11950	COG2203	Gaf domain
amad1_11950	COG3706	GGDEF domain
amad1_11950	COG4251	negative regulation of phosphorylation
amad1_11970	COG0583	DNA-binding transcription factor activity
amad1_11990	COG0640	Transcriptional regulator
amad1_12010	COG2204	response regulator
amad1_12020	COG4251	negative regulation of phosphorylation
amad1_12025	COG0784	Response regulator, receiver
amad1_12030	COG0784	Response regulator, receiver
amad1_12030	COG2205	protein histidine kinase activity
amad1_12055	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
amad1_12080	COG3139	Protein of unknown function (DUF1315)
amad1_12095	COG1115	amino acid carrier protein
amad1_12100	COG2866	Carboxypeptidase
amad1_12120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
amad1_12130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
amad1_12135	COG1640	4-alpha-glucanotransferase
amad1_12140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
amad1_12145	COG0676	glucose-6-phosphate 1-epimerase activity
amad1_12150	COG0800	Aldolase
amad1_12160	COG0129	dihydroxy-acid dehydratase activity
amad1_12170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
amad1_12175	COG1737	Transcriptional regulator
amad1_12180	COG0469	pyruvate kinase activity
amad1_12195	COG1960	acyl-CoA dehydrogenase activity
amad1_12215	COG0490	domain, Protein
amad1_12215	COG0471	metal ion transport
amad1_12225	COG0800	Aldolase
amad1_12235	COG0129	dihydroxy-acid dehydratase activity
amad1_12245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
amad1_12250	COG1737	Transcriptional regulator
amad1_12255	COG0469	pyruvate kinase activity
amad1_12260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
amad1_12280	COG2823	Periplasmic or secreted lipoprotein
amad1_12310	COG3665	Urea carboxylase-associated protein
amad1_12350	COG2356	endonuclease I
amad1_12370	COG0583	DNA-binding transcription factor activity
amad1_12375	COG1979	alcohol dehydrogenase
amad1_12390	COG3437	response regulator, receiver
amad1_12390	COG0784	Response regulator, receiver
amad1_12395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
amad1_12395	COG4191	Histidine kinase
amad1_12485	COG0471	metal ion transport
amad1_12495	COG0489	protein tyrosine kinase activity
amad1_12500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
amad1_12500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
amad1_12505	COG0668	transmembrane transport
amad1_12510	COG2226	methyltransferase
amad1_12515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
amad1_12520	COG1388	LysM domain
amad1_12520	COG0741	lytic transglycosylase activity
amad1_12545	COG0215	cysteine-tRNA ligase activity
amad1_12550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
amad1_12555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
amad1_12565	COG2268	Band 7 protein
amad1_12580	COG1733	regulation of RNA biosynthetic process
amad1_12585	COG0604	alcohol dehydrogenase
amad1_12590	COG0753	catalase activity
amad1_12595	COG0604	alcohol dehydrogenase
amad1_12600	COG0583	DNA-binding transcription factor activity
amad1_12635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
amad1_12640	COG1286	toxin biosynthetic process
amad1_12645	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
amad1_12650	COG0285	dihydrofolate synthase activity
amad1_12670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
amad1_12675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
amad1_12695	COG3609	addiction module antidote protein, CC2985 family
amad1_12705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
amad1_12710	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_12720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
amad1_12720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
amad1_12755	COG0789	Transcriptional regulator
amad1_12760	COG0604	alcohol dehydrogenase
amad1_12785	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_12790	COG1119	ATPase activity
amad1_12795	COG2031	fatty acid transporter
amad1_12800	COG2205	protein histidine kinase activity
amad1_12800	COG0784	Response regulator, receiver
amad1_12800	COG5002	protein histidine kinase activity
amad1_12810	COG0612	Peptidase, M16
amad1_12825	COG3101	peptidyl-lysine hydroxylation
amad1_12855	COG1902	pentaerythritol trinitrate reductase activity
amad1_12855	COG0446	pyridine nucleotide-disulphide oxidoreductase
amad1_12880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
amad1_12890	COG4399	Belongs to the UPF0754 family
amad1_12915	COG1770	oligopeptidase
amad1_12920	COG2186	Transcriptional regulator
amad1_12930	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
amad1_12935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
amad1_12945	COG2983	Belongs to the UPF0260 family
amad1_12950	COG0179	Fumarylacetoacetate (FAA) hydrolase
amad1_12965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
amad1_12970	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_12975	COG2267	carboxylic ester hydrolase activity
amad1_12990	COG1214	PFAM Peptidase M22, glycoprotease
amad1_12995	COG1199	ATP-dependent helicase activity
amad1_13045	COG4771	TonB-dependent receptor
amad1_13055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
amad1_13060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
amad1_13065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
amad1_13070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
amad1_13070	COG0131	Imidazoleglycerol-phosphate dehydratase
amad1_13075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
amad1_13090	COG0140	phosphoribosyl-ATP diphosphatase activity
amad1_13090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
amad1_13105	COG2116	formate transmembrane transporter activity
amad1_13110	COG0612	Peptidase, M16
amad1_13145	COG0326	Molecular chaperone. Has ATPase activity
amad1_13150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
amad1_13180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
amad1_13190	COG3220	belongs to the UPF0276 family
amad1_13200	COG1136	(ABC) transporter
amad1_13200	COG0577	efflux transmembrane transporter activity
amad1_13210	COG5001	Diguanylate cyclase
amad1_13210	COG4251	negative regulation of phosphorylation
amad1_13210	COG3706	GGDEF domain
amad1_13210	COG2203	Gaf domain
amad1_13215	COG1183	phosphatidylcholine synthase activity
amad1_13235	COG0277	FAD linked oxidase domain protein
amad1_13240	COG0542	response to heat
amad1_13250	COG0564	pseudouridine synthase activity
amad1_13265	COG1595	DNA-templated transcription, initiation
amad1_13280	COG4221	oxidoreductase activity
amad1_13295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
amad1_13305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
amad1_13315	COG0142	geranyltranstransferase activity
amad1_13325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
amad1_13330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
amad1_13340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
amad1_13355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
amad1_13355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
amad1_13375	COG0488	(ABC) transporter
amad1_13385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
amad1_13395	COG0560	Phosphoserine phosphatase
amad1_13405	COG0084	hydrolase, TatD family'
amad1_13420	COG0571	ribonuclease III activity
amad1_13425	COG0681	Belongs to the peptidase S26 family
amad1_13450	COG1595	DNA-templated transcription, initiation
amad1_13455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
amad1_13470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
amad1_13550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
amad1_13555	COG1047	Peptidyl-prolyl cis-trans
amad1_13565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amad1_13570	COG0196	riboflavin kinase activity
amad1_13575	COG0728	peptidoglycan biosynthetic process
amad1_13580	COG0268	Binds directly to 16S ribosomal RNA
amad1_13600	COG0385	Bile acid
amad1_13630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
amad1_13635	COG0776	regulation of translation
amad1_13645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
amad1_13650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
amad1_13655	COG0740	serine-type endopeptidase activity
amad1_13660	COG0544	peptidyl-prolyl cis-trans isomerase activity
amad1_13675	COG1720	tRNA m6t6A37 methyltransferase activity
amad1_13685	COG1234	tRNA 3'-trailer cleavage
amad1_13695	COG0123	including yeast histone deacetylase and acetoin utilization protein
amad1_13710	COG0516	GMP reductase activity
amad1_13710	COG0517	IMP dehydrogenase activity
amad1_13715	COG1570	exodeoxyribonuclease VII activity
amad1_13735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
amad1_13740	COG2976	Protein conserved in bacteria
amad1_13765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
amad1_13775	COG2166	iron-sulfur cluster assembly
amad1_13790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
amad1_13795	COG0719	Fe-S assembly protein
amad1_13800	COG0396	ATPase activity
amad1_13805	COG0719	Fe-S assembly protein
amad1_13810	COG1104	cysteine desulfurase activity
amad1_13820	COG2072	flavoprotein involved in K transport
amad1_13825	COG1045	serine acetyltransferase
amad1_13830	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
amad1_13835	COG0483	inositol monophosphate 1-phosphatase activity
amad1_13850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
amad1_13855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
amad1_13860	COG1862	Preprotein translocase
amad1_13865	COG0343	queuine tRNA-ribosyltransferase activity
amad1_13885	COG1842	Phage shock protein A
amad1_13890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
amad1_13910	COG0754	glutathionylspermidine amidase activity
amad1_13940	COG2066	Belongs to the glutaminase family
amad1_13945	COG1785	Belongs to the alkaline phosphatase family
amad1_14000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
amad1_14020	COG0438	transferase activity, transferring glycosyl groups
amad1_14040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
amad1_14045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
amad1_14075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
amad1_14075	COG2755	lipolytic protein G-D-S-L family
amad1_14080	COG0367	asparagine synthase
amad1_14085	COG0438	transferase activity, transferring glycosyl groups
amad1_14095	COG2244	polysaccharide biosynthetic process
amad1_14125	COG0367	asparagine synthase
amad1_14160	COG0489	protein tyrosine kinase activity
amad1_14170	COG3409	Peptidoglycan-binding domain 1 protein
amad1_14170	COG3267	Type II secretory pathway component ExeA
amad1_14230	COG1560	Kdo2-lipid A biosynthetic process
amad1_14245	COG1960	acyl-CoA dehydrogenase activity
amad1_14260	COG3300	MHYT domain
amad1_14260	COG5001	Diguanylate cyclase
amad1_14265	COG1435	thymidine kinase activity
amad1_14275	COG1609	Transcriptional regulator
amad1_14280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
amad1_14310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
amad1_14315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
amad1_14320	COG1024	Enoyl-CoA hydratase
amad1_14320	COG1250	3-hydroxyacyl-CoA dehydrogenase
amad1_14335	COG1012	belongs to the aldehyde dehydrogenase family
amad1_14355	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
amad1_14380	COG1960	acyl-CoA dehydrogenase activity
amad1_14410	COG0745	RESPONSE REGULATOR receiver
amad1_14415	COG2205	protein histidine kinase activity
amad1_14455	COG2080	2 iron, 2 sulfur cluster binding
amad1_14460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
amad1_14465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
amad1_14485	COG1028	Short-chain dehydrogenase reductase Sdr
amad1_14490	COG4221	oxidoreductase activity
amad1_14495	COG0693	protein deglycase activity
amad1_14500	COG1295	ribonuclease BN
amad1_14510	COG4681	YaeQ
amad1_14540	COG2814	Major facilitator Superfamily
amad1_14555	COG0514	ATP-dependent DNA helicase (RecQ)
amad1_14585	COG4251	negative regulation of phosphorylation
amad1_14590	COG2133	pyrroloquinoline quinone binding
amad1_14595	COG3609	addiction module antidote protein, CC2985 family
amad1_14630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
amad1_14635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
amad1_14650	COG0330	HflC and HflK could
amad1_14745	COG4772	TonB-dependent receptor
amad1_14780	COG1230	cation diffusion facilitator family transporter
amad1_14790	COG4372	Transposase
amad1_14805	COG1017	nitric oxide dioxygenase activity
amad1_14805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
amad1_14810	COG3604	Transcriptional regulator
amad1_14840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
amad1_14845	COG2971	BadF BadG BcrA BcrD
amad1_14850	COG0583	DNA-binding transcription factor activity
amad1_14855	COG1620	l-lactate permease
amad1_14880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
amad1_14885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
amad1_14890	COG0006	proline dipeptidase activity
amad1_14900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
amad1_14915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
amad1_14920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
amad1_14925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
amad1_14945	COG3313	Fe-S protein
amad1_14980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_14985	COG0508	dehydrogenase complex catalyzes the overall conversion of
amad1_14990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
amad1_14995	COG2186	Transcriptional regulator
amad1_15005	COG3023	N-Acetylmuramoyl-L-alanine amidase
amad1_15010	COG3577	Aspartyl protease
amad1_15015	COG0157	Belongs to the NadC ModD family
amad1_15025	COG1459	type II secretion system
amad1_15030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
amad1_15040	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
amad1_15050	COG3608	succinylglutamate desuccinylase aspartoacylase
amad1_15055	COG0494	nUDIX hydrolase
amad1_15065	COG0739	heme binding
amad1_15070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
amad1_15075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
amad1_15080	COG0849	cell division
amad1_15085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
amad1_15090	COG1181	Belongs to the D-alanine--D-alanine ligase family
amad1_15095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
amad1_15105	COG0772	Belongs to the SEDS family
amad1_15110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
amad1_15120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
amad1_15125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
amad1_15130	COG0768	penicillin binding
amad1_15135	COG3116	cell division
amad1_15145	COG2001	Belongs to the MraZ family
amad1_15195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
amad1_15195	COG0678	peroxiredoxin activity
amad1_15210	COG3706	GGDEF domain
amad1_15220	COG2204	response regulator
amad1_15225	COG2205	protein histidine kinase activity
amad1_15225	COG0784	Response regulator, receiver
amad1_15255	COG0668	transmembrane transport
amad1_15260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
amad1_15265	COG0189	ligase activity
amad1_15270	COG1678	Uncharacterized ACR, COG1678
amad1_15275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
amad1_15300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
amad1_15305	COG0762	integral membrane protein
amad1_15315	COG0446	pyridine nucleotide-disulphide oxidoreductase
amad1_15315	COG1902	pentaerythritol trinitrate reductase activity
amad1_15330	COG0625	glutathione transferase activity
amad1_15340	COG1764	response to oxidative stress
amad1_15345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
amad1_15360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
amad1_15370	COG2814	Major facilitator Superfamily
amad1_15375	COG0724	RNA recognition motif
amad1_15405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
amad1_15410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
amad1_15430	COG0583	DNA-binding transcription factor activity
amad1_15445	COG0640	Transcriptional regulator
amad1_15455	COG0431	NADPH-dependent FMN reductase
amad1_15460	COG0798	PFAM Bile acid sodium symporter
amad1_15465	COG2201	protein-glutamate methylesterase activity
amad1_15470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
amad1_15480	COG0642	Histidine kinase
amad1_15510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
amad1_15540	COG1748	Saccharopine dehydrogenase
amad1_15555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
amad1_15560	COG3107	peptidoglycan biosynthetic process
amad1_15570	COG0438	transferase activity, transferring glycosyl groups
amad1_15580	COG2823	Periplasmic or secreted lipoprotein
amad1_15600	COG4585	Histidine kinase
amad1_15605	COG2197	response regulator
amad1_15620	COG4771	TonB-dependent receptor
amad1_15630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
amad1_15635	COG0372	Belongs to the citrate synthase family
amad1_15640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
amad1_15645	COG2828	Protein conserved in bacteria
amad1_15650	COG2203	Gaf domain
amad1_15650	COG2199	diguanylate cyclase activity
amad1_15655	COG1940	carbohydrate kinase activity
amad1_15705	COG0784	Response regulator, receiver
amad1_15705	COG2198	Histidine kinase
amad1_15705	COG5002	protein histidine kinase activity
amad1_15710	COG3023	N-Acetylmuramoyl-L-alanine amidase
amad1_15715	COG0067	glutamate synthase
amad1_15715	COG0070	glutamate synthase
amad1_15715	COG0069	glutamate synthase activity
amad1_15720	COG0493	'glutamate synthase
amad1_15735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
amad1_15740	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
amad1_15745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
amad1_15750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
amad1_15765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
amad1_15770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
amad1_15780	COG4942	peptidase
amad1_15785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
amad1_15790	COG0738	Major facilitator superfamily
amad1_15800	COG1902	pentaerythritol trinitrate reductase activity
amad1_15820	COG0625	glutathione transferase activity
amad1_15845	COG2894	cell division
amad1_15850	COG0850	regulation of cytokinetic process
amad1_15860	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
amad1_15890	COG1914	H( )-stimulated, divalent metal cation uptake system
amad1_15895	COG0436	Aminotransferase
amad1_15915	COG0174	glutamine synthetase
amad1_15925	COG3852	Histidine kinase
amad1_15930	COG2204	response regulator
amad1_15935	COG3437	response regulator, receiver
amad1_15940	COG0204	Acyl-transferase
amad1_15985	COG3850	Histidine kinase
amad1_15985	COG4999	Histidine kinase
amad1_15985	COG3437	response regulator, receiver
amad1_15985	COG2205	protein histidine kinase activity
amad1_15990	COG0525	valine-tRNA ligase activity
amad1_15995	COG2927	DNA polymerase III (CHI subunit)
amad1_16000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
amad1_16005	COG0795	lipopolysaccharide-transporting ATPase activity
amad1_16010	COG0795	lipopolysaccharide-transporting ATPase activity
amad1_16095	COG4974	Belongs to the 'phage' integrase family
amad1_16110	COG2856	Zn peptidase
amad1_16225	COG3250	beta-galactosidase activity
amad1_16235	COG4948	Mandelate Racemase Muconate Lactonizing
amad1_16240	COG3661	Belongs to the glycosyl hydrolase 67 family
amad1_16255	COG2199	diguanylate cyclase activity
amad1_16255	COG2203	Gaf domain
amad1_16280	COG0673	inositol 2-dehydrogenase activity
amad1_16285	COG2205	protein histidine kinase activity
amad1_16285	COG0784	Response regulator, receiver
amad1_16285	COG2198	Histidine kinase
amad1_16285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
amad1_16290	COG0628	permease
amad1_16305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
amad1_16310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
amad1_16315	COG4558	Periplasmic binding protein
amad1_16325	COG4206	TonB-dependent receptor
amad1_16335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
amad1_16340	COG0697	spore germination
amad1_16365	COG1971	Probably functions as a manganese efflux pump
amad1_16375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
amad1_16390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
amad1_16405	COG0679	Auxin Efflux Carrier
amad1_16435	COG1131	(ABC) transporter
amad1_16445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
amad1_16455	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
amad1_16495	COG2205	protein histidine kinase activity
amad1_16505	COG3901	Regulator of nitric oxide reductase transcription
amad1_16505	COG0348	domain, Protein
amad1_16515	COG2197	response regulator
amad1_16540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
amad1_16555	COG4771	TonB-dependent receptor
amad1_16565	COG0583	DNA-binding transcription factor activity
amad1_16570	COG1304	FMN binding
amad1_16575	COG0277	FAD linked oxidase domain protein
amad1_16585	COG1462	curli production assembly transport component CsgG
amad1_16615	COG2197	response regulator
amad1_16630	COG0513	Belongs to the DEAD box helicase family
amad1_16640	COG1294	oxidase, subunit
amad1_16645	COG1271	oxidase subunit
amad1_16660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
amad1_16670	COG2124	cytochrome p450
amad1_16690	COG2203	Gaf domain
amad1_16690	COG2199	diguanylate cyclase activity
amad1_16740	COG2337	Toxic component of a toxin-antitoxin (TA) module
amad1_16770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
amad1_16780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
amad1_16795	COG1271	oxidase subunit
amad1_16800	COG1294	oxidase, subunit
amad1_16835	COG3264	Mechanosensitive ion channel
amad1_16835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
amad1_16880	COG0730	response to heat
amad1_16900	COG4191	Histidine kinase
amad1_16910	COG0417	DNA replication proofreading
amad1_16920	COG0318	PFAM AMP-dependent synthetase and ligase
amad1_16940	COG1309	transcriptional regulator
amad1_16950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_16960	COG1573	uracil-dna glycosylase
amad1_16965	COG5001	Diguanylate cyclase
amad1_16965	COG3300	MHYT domain
amad1_16985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
amad1_17005	COG1983	PspC domain protein
amad1_17010	COG1842	Phage shock protein A
amad1_17020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
amad1_17040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
amad1_17040	COG2885	chlorophyll binding
amad1_17045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
amad1_17055	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
amad1_17060	COG0204	Acyl-transferase
amad1_17065	COG0204	Acyl-transferase
amad1_17070	COG0668	transmembrane transport
amad1_17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
amad1_17090	COG0733	neurotransmitter:sodium symporter activity
amad1_17105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
amad1_17120	COG0716	FMN binding
amad1_17130	COG0848	biopolymer transport protein
amad1_17145	COG0457	Tetratricopeptide repeat
amad1_17150	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
amad1_17160	COG1215	transferase activity, transferring glycosyl groups
amad1_17175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
amad1_17180	COG0702	epimerase
amad1_17195	COG5001	Diguanylate cyclase
amad1_17195	COG5002	protein histidine kinase activity
amad1_17210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
amad1_17220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
amad1_17230	COG0583	DNA-binding transcription factor activity
amad1_17235	COG0121	glutamine amidotransferase
amad1_17240	COG4682	membrane
amad1_17260	COG1953	Uracil, thiamine, allantoin
amad1_17265	COG4771	TonB-dependent receptor
amad1_17275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
amad1_17280	COG0778	Nitroreductase
amad1_17285	COG0596	Alpha beta hydrolase
amad1_17290	COG0251	oxidation-reduction process
amad1_17295	COG1335	isochorismatase
amad1_17300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
amad1_17305	COG1309	transcriptional regulator
amad1_17320	COG4628	conserved protein (DUF2132)
amad1_17325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
amad1_17335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
amad1_17345	COG1477	protein flavinylation
amad1_17350	COG2871	sodium ion transport
amad1_17355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
amad1_17360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
amad1_17365	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
amad1_17370	COG1805	sodium ion transport
amad1_17375	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
amad1_17380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
amad1_17385	COG0545	Peptidyl-prolyl cis-trans isomerase
amad1_17390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
amad1_17395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
amad1_17410	COG0039	L-malate dehydrogenase activity
amad1_17415	COG1438	arginine binding
amad1_17440	COG0572	uridine kinase
amad1_17445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
amad1_17465	COG3706	GGDEF domain
amad1_17465	COG0745	RESPONSE REGULATOR receiver
amad1_17470	COG2176	DNA-directed DNA polymerase activity
amad1_17475	COG0517	IMP dehydrogenase activity
amad1_17475	COG1125	glycine betaine transport
amad1_17480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
amad1_17490	COG2205	protein histidine kinase activity
amad1_17500	COG0189	ligase activity
amad1_17510	COG0189	ligase activity
amad1_17510	COG4067	protein conserved in archaea
amad1_17535	COG1283	sodium-dependent phosphate transmembrane transporter activity
amad1_17540	COG0667	Aldo Keto reductase
amad1_17555	COG5001	Diguanylate cyclase
amad1_17570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
amad1_17580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
amad1_17585	COG0840	transmembrane signaling receptor activity
amad1_17610	COG2274	protein secretion by the type I secretion system
amad1_17615	COG0583	DNA-binding transcription factor activity
amad1_17640	COG0438	transferase activity, transferring glycosyl groups
amad1_17640	COG1216	Glycosyl transferase, family 2
amad1_17680	COG0457	Tetratricopeptide repeat
amad1_17720	COG1216	Glycosyl transferase, family 2
amad1_17720	COG0463	Glycosyl transferase, family 2
amad1_17805	COG4372	Transposase
amad1_17825	COG4372	Transposase
amad1_17875	COG2161	toxin-antitoxin pair type II binding
amad1_17885	COG0202	RNA polymerase activity
amad1_17910	COG0201	protein transport
amad1_17930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
amad1_17965	COG0784	Response regulator, receiver
amad1_17965	COG5002	protein histidine kinase activity
amad1_17990	COG0557	exoribonuclease II activity
amad1_18020	COG4771	TonB-dependent receptor
amad1_18035	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
amad1_18050	COG0543	2 iron, 2 sulfur cluster binding
amad1_18065	COG2234	aminopeptidase activity
amad1_18075	COG4251	negative regulation of phosphorylation
amad1_18085	COG1271	oxidase subunit
amad1_18090	COG1294	oxidase, subunit
amad1_18100	COG1522	sequence-specific DNA binding
amad1_18110	COG1278	Cold shock
amad1_18115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
amad1_18135	COG0339	signal peptide processing
amad1_18140	COG2201	protein-glutamate methylesterase activity
amad1_18150	COG3852	Histidine kinase
amad1_18160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
amad1_18165	COG0243	molybdopterin cofactor binding
amad1_18170	COG4946	Tricorn protease homolog
amad1_18170	COG0823	Involved in the tonB-independent uptake of proteins
amad1_18170	COG1506	peptidase
amad1_18220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
amad1_18230	COG2197	response regulator
amad1_18240	COG0189	ligase activity
amad1_18260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
amad1_18265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
amad1_18270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
amad1_18285	COG0281	malic enzyme
amad1_18295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
amad1_18325	COG0456	acetyltransferase
amad1_18335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
amad1_18340	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
amad1_18345	COG2177	Part of the ABC transporter FtsEX involved in
amad1_18350	COG2884	Cell division ATP-binding protein ftsE
amad1_18355	COG0552	protein localization to endoplasmic reticulum
amad1_18360	COG0742	ribosomal rna small subunit methyltransferase
amad1_18370	COG2095	MarC family integral membrane protein
amad1_18390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
amad1_18395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
amad1_18400	COG0617	tRNA 3'-terminal CCA addition
amad1_18405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
amad1_18420	COG0076	glutamate decarboxylase activity
amad1_18440	COG0842	Transport permease protein
amad1_18445	COG1131	(ABC) transporter
amad1_18450	COG0745	RESPONSE REGULATOR receiver
amad1_18455	COG2205	protein histidine kinase activity
amad1_18460	COG4774	siderophore transport
amad1_18480	COG1253	flavin adenine dinucleotide binding
amad1_18490	COG1966	Carbon starvation protein
amad1_18515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
amad1_18520	COG0049	tRNA binding
amad1_18525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
amad1_18530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
amad1_18535	COG0085	RNA polymerase activity
amad1_18540	COG0222	ribosome binding
amad1_18545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
amad1_18550	COG0081	regulation of translation
amad1_18555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
amad1_18575	COG0250	Participates in transcription elongation, termination and antitermination
amad1_18580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
amad1_18585	COG1132	(ABC) transporter
amad1_18590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
amad1_18595	COG3590	peptidase
amad1_18605	COG0513	Belongs to the DEAD box helicase family
amad1_18610	COG0418	dihydroorotase activity
amad1_18615	COG3040	lipid binding
amad1_18620	COG4989	oxidoreductase activity
amad1_18625	COG0346	lactoylglutathione lyase activity
amad1_18630	COG0668	transmembrane transport
amad1_18650	COG0302	gtp cyclohydrolase
amad1_18660	COG2957	Belongs to the agmatine deiminase family
amad1_18665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
amad1_18680	COG1201	RNA secondary structure unwinding
amad1_18690	COG1793	dna ligase
amad1_18695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
amad1_18700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
amad1_18710	COG0646	methionine synthase
amad1_18710	COG1410	methionine synthase
amad1_18715	COG0625	glutathione transferase activity
amad1_18720	COG0625	glutathione transferase activity
amad1_18730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
amad1_18745	COG1012	belongs to the aldehyde dehydrogenase family
amad1_18750	COG0028	Belongs to the TPP enzyme family
amad1_18760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
amad1_18765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
amad1_18770	COG0330	HflC and HflK could
amad1_18775	COG0330	HflC and HflK could
amad1_18780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
amad1_18785	COG1923	regulation of RNA biosynthetic process
amad1_18790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
amad1_18805	COG0802	atpase or kinase
amad1_18810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
amad1_18810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
amad1_18815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
amad1_18825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
amad1_18835	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
amad1_18840	COG0735	belongs to the Fur family
amad1_18850	COG0432	Pfam Uncharacterised protein family UPF0047
amad1_18860	COG0305	Participates in initiation and elongation during chromosome replication
amad1_18885	COG2258	MOSC domain
amad1_18915	COG2205	protein histidine kinase activity
amad1_18935	COG0840	transmembrane signaling receptor activity
amad1_18940	COG5002	protein histidine kinase activity
amad1_18980	COG1472	Belongs to the glycosyl hydrolase 3 family
amad1_18990	COG2723	6-phospho-beta-galactosidase activity
amad1_18995	COG1609	Transcriptional regulator
amad1_19000	COG2814	Major facilitator Superfamily
amad1_19000	COG0477	Major facilitator Superfamily
amad1_19005	COG4319	ketosteroid isomerase
amad1_19025	COG2375	cellular response to nickel ion
amad1_19030	COG3237	CsbD-like
amad1_19060	COG0596	Alpha beta hydrolase
amad1_19060	COG0508	dehydrogenase complex catalyzes the overall conversion of
amad1_19080	COG3038	cytochrome b561
amad1_19090	COG1252	NADH dehydrogenase
amad1_19105	COG0583	DNA-binding transcription factor activity
amad1_19110	COG2067	long-chain fatty acid transport protein
amad1_19115	COG2130	NADP-dependent
amad1_19120	COG5001	Diguanylate cyclase
amad1_19120	COG4251	negative regulation of phosphorylation
amad1_19120	COG3706	GGDEF domain
amad1_19120	COG2203	Gaf domain
amad1_19125	COG0784	Response regulator, receiver
amad1_19125	COG2205	protein histidine kinase activity
amad1_19135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
amad1_19140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
amad1_19145	COG1349	DNA-binding transcription factor activity
amad1_19150	COG0673	inositol 2-dehydrogenase activity
amad1_19165	COG0697	spore germination
amad1_19170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
amad1_19175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
amad1_19180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
amad1_19185	COG1166	arginine decarboxylase activity
amad1_19195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
amad1_19200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
amad1_19205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
amad1_19275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
amad1_19280	COG0109	protoheme IX farnesyltransferase activity
amad1_19300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
amad1_19345	COG3030	protein affecting phage T7 exclusion by the F plasmid
amad1_19350	COG1324	tolerance protein
amad1_19355	COG4232	protein-disulfide reductase activity
amad1_19360	COG0739	heme binding
amad1_19365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
amad1_19370	COG0511	ligase activity, forming carbon-carbon bonds
amad1_19375	COG0439	Biotin carboxylase
amad1_19425	COG0154	amidase activity
amad1_19440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
amad1_19445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
amad1_19460	COG0151	Belongs to the GarS family
amad1_19475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
amad1_19480	COG3954	Phosphoribulokinase
amad1_19490	COG0745	RESPONSE REGULATOR receiver
amad1_19510	COG1501	Belongs to the glycosyl hydrolase 31 family
amad1_19525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
amad1_19535	COG3031	protein transport across the cell outer membrane
amad1_19545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
amad1_19550	COG1459	type II secretion system
amad1_19555	COG2165	general secretion pathway protein
amad1_19560	COG2165	general secretion pathway protein
amad1_19565	COG2165	general secretion pathway protein
amad1_19570	COG4795	General secretion pathway protein
amad1_19585	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
amad1_19600	COG1012	belongs to the aldehyde dehydrogenase family
amad1_19610	COG1011	Hydrolase
amad1_19615	COG0494	nUDIX hydrolase
amad1_19620	COG1218	3'(2'),5'-bisphosphate nucleotidase
amad1_19635	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
amad1_19645	COG3089	Belongs to the UPF0270 family
amad1_19650	COG0429	hydrolase of the alpha beta-hydrolase fold
amad1_19660	COG0488	(ABC) transporter
amad1_19680	COG2900	Belongs to the SlyX family
amad1_19690	COG0545	Peptidyl-prolyl cis-trans isomerase
amad1_19700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
amad1_19705	COG2183	response to ionizing radiation
amad1_19735	COG2207	Transcriptional regulator
amad1_19735	COG1609	Transcriptional regulator
amad1_19740	COG2211	Major facilitator Superfamily
amad1_19755	COG3693	PFAM glycoside hydrolase, family 10
amad1_19760	COG0667	Aldo Keto reductase
amad1_19765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
amad1_19770	COG2115	Belongs to the xylose isomerase family
amad1_19775	COG1070	Carbohydrate kinase
amad1_19790	COG1472	Belongs to the glycosyl hydrolase 3 family
amad1_19795	COG0477	Major facilitator Superfamily
amad1_19840	COG0596	Alpha beta hydrolase
amad1_19845	COG1040	competence protein
amad1_19865	COG1794	racemase activity, acting on amino acids and derivatives
amad1_19875	COG0534	Mate efflux family protein
amad1_19890	COG1999	signal sequence binding
amad1_19895	COG0109	protoheme IX farnesyltransferase activity
amad1_19900	COG1612	heme a metabolic process
amad1_19920	COG1845	cytochrome c oxidase, subunit III
amad1_19925	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
amad1_19930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
amad1_19935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
amad1_19960	COG0129	dihydroxy-acid dehydratase activity
amad1_19970	COG0606	chelatase, subunit chli
amad1_19975	COG0583	DNA-binding transcription factor activity
amad1_19985	COG2814	Major facilitator Superfamily
amad1_19995	COG0729	surface antigen
amad1_20000	COG2911	Protein conserved in bacteria
amad1_20025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
amad1_20035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
amad1_20055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
amad1_20080	COG1228	amidohydrolase
amad1_20105	COG0425	Belongs to the sulfur carrier protein TusA family
amad1_20125	COG1561	YicC-like family, N-terminal region
amad1_20135	COG3550	peptidyl-serine autophosphorylation
amad1_20140	COG3620	sequence-specific DNA binding
amad1_20210	COG5433	transposase activity
amad1_20215	COG3119	arylsulfatase activity
amad1_20220	COG0714	Associated with various cellular activities
amad1_20235	COG2304	oxidoreductase activity
amad1_20270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
amad1_20280	COG1960	acyl-CoA dehydrogenase activity
amad1_20290	COG1024	Enoyl-CoA hydratase
amad1_20300	COG2801	Transposase and inactivated derivatives
amad1_20310	COG0800	Aldolase
amad1_20320	COG0129	dihydroxy-acid dehydratase activity
amad1_20330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
amad1_20335	COG1737	Transcriptional regulator
amad1_20340	COG0469	pyruvate kinase activity
amad1_20370	COG3177	Filamentation induced by cAMP protein fic
amad1_20380	COG1609	Transcriptional regulator
amad1_20395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
amad1_20395	COG2199	diguanylate cyclase activity
amad1_20420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
amad1_20440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
amad1_20445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
amad1_20465	COG1475	DNA binding
amad1_20470	COG1192	Involved in chromosome partitioning
amad1_20495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
amad1_20500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
amad1_20510	COG0706	membrane insertase activity
amad1_20515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
amad1_20520	COG0594	ribonuclease P activity
amad1_21238	COG1132	(ABC) transporter
amad1_21258	COG2801	Transposase and inactivated derivatives
amad1_21338	COG2201	protein-glutamate methylesterase activity
amad1_21378	COG5290	Psort location Cytoplasmic, score
amad1_21418	COG3209	COG3209 Rhs family protein
amad1_21428	COG3209	COG3209 Rhs family protein
amad1_21553	COG5310	Homospermidine synthase
amad1_21578	COG3251	PFAM MbtH domain protein
amad1_21743	COG0210	DNA helicase
amad1_21783	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
amad1_21813	COG4584	PFAM Integrase catalytic
amad1_21953	COG4584	PFAM Integrase catalytic
amad1_21958	COG1484	DNA-dependent DNA replication
amad1_21973	COG5001	Diguanylate cyclase
amad1_21973	COG3300	MHYT domain
amad1_21988	COG3706	GGDEF domain
amad1_22073	COG1192	Involved in chromosome partitioning