locus-tag class description I533_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) I533_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) I533_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) I533_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I533_00030 ENOG4105C38 Glycyl-tRNA synthetase beta subunit I533_00035 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit I533_00040 ENOG4108R3E Dna-3-methyladenine glycosylase i I533_00050 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) I533_00060 ENOG4106RE7 Cytochrome I533_00065 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) I533_00070 ENOG4105C2M dna polymerase I I533_00075 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain I533_00080 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) I533_00085 ENOG4105C1A potassium transporter peripheral membrane I533_00090 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B I533_00095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) I533_00100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) I533_00110 ENOG4105C79 DNA protecting protein DprA I533_00115 ENOG4108RPN Protein smg homolog I533_00125 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I533_00130 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) I533_00135 ENOG4105EIF outer membrane protein W I533_00145 ENOG4105E2X shikimate dehydrogenase I533_00150 ENOG4108Z0R Transferase I533_00160 ENOG41061N2 exported protein I533_00175 ENOG4105C0B DNA polymerase III (alpha subunit) I533_00205 ENOG4105IIU Aminopeptidase I533_00210 ENOG4106WTF Glycosyl transferase, family 2 I533_00215 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) I533_00220 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase I533_00225 ENOG4105W5Q DNA repair protein (RadC I533_00245 ENOG4105E3R (LipO)protein I533_00250 ENOG4105KDC 50s ribosomal protein l28 I533_00255 ENOG4105W0E 50S ribosomal protein L33 I533_00265 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) I533_00270 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) I533_00275 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) I533_00280 ENOG4105DKP glycosyl transferase, family 9 I533_00295 ENOG4105BZU Histidine kinase I533_00300 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I533_00305 ENOG4105CPQ Dehydrogenase I533_00310 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) I533_00325 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) I533_00330 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) I533_00345 ENOG4105W0Z cytoplasmic protein I533_00350 ENOG4105C4R Atp-dependent dna helicase I533_00355 ENOG4105BZU Histidine kinase I533_00360 ENOG4105MPD Cytochrome I533_00380 ENOG4105DFD Na H antiporter I533_00400 ENOG4108VCT Sulfite exporter TauE/SafE I533_00415 ENOG4105D05 Receptor I533_00430 ENOG4108JJ8 (ABC) transporter I533_00435 ENOG4108JJ9 ABC, transporter I533_00445 ENOG4105C4M (Ubiquinol oxidase) subunit I I533_00455 ENOG4105VFE sira family I533_00465 ENOG4105D3R alkyl hydroperoxide reductase I533_00475 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I533_00505 ENOG4105C94 Transporter I533_00525 ENOG4108KU3 Integrase I533_00555 ENOG4105D0S secretion protein (HlyD I533_00560 ENOG4105CJ1 ABC, transporter I533_00565 ENOG4105CMI transporter I533_00575 ENOG4107RNH Outer membrane receptor FepA I533_00585 ENOG4105C1G acyl-Coa dehydrogenase I533_00590 ENOG4105DQS Transcriptional regulator I533_00600 ENOG4105CM6 amino acid regulated cytosolic protein I533_00620 ENOG4105D41 biosynthesis protein thiH I533_00625 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) I533_00635 ENOG4105D06 uba thif-type nad fad binding protein I533_00640 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) I533_00645 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) I533_00650 ENOG410601J HemY protein I533_00655 ENOG4105ECF c-methyltransferase I533_00660 ENOG41076E6 Uroporphyrinogen-III Synthase I533_00665 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) I533_00685 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) I533_00690 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) I533_00695 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) I533_00700 ENOG4105KME endoribonuclease L-psp I533_00705 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase I533_00710 ENOG4105CB5 ATP-dependent DNA helicase recG I533_00715 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) I533_00735 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component I533_00740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) I533_00750 ENOG4105CBX hi0933 family I533_00780 ENOG4105BZU Histidine kinase I533_00785 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) I533_00795 ENOG4105KPY Small multidrug resistance protein I533_00810 ENOG4105C1P efflux transporter, rnd family, mfp subunit I533_00815 ENOG4105BZS acriflavin resistance protein I533_00825 ENOG4105CYC Transferase I533_00845 ENOG4108N3W hemolysin secretion protein I533_00855 ENOG4108NST exported protein I533_00860 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) I533_00865 ENOG4105BZU Histidine kinase I533_00880 ENOG4105C9U ATP-dependent DNA helicase RecQ I533_00885 ENOG4105CJW magnesium transporter I533_00890 ENOG4105FR1 rard protein I533_00895 ENOG4105BZU Histidine kinase I533_00900 ENOG4105C4R Atp-dependent dna helicase I533_00905 ENOG4105D7W serine acetyltransferase I533_00910 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant I533_00915 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I533_00925 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) I533_00930 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) I533_00950 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) I533_00960 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase I533_00965 ENOG4105DFU Cell wall formation (By similarity) I533_00970 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 I533_00975 ENOG4105F0N pyrophosphate phospho-hydrolase I533_01005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) I533_01010 ENOG4107RDB Major Facilitator I533_01015 ENOG4107VXZ Hydrolase I533_01045 ENOG4105F0Z galactose-1-phosphate uridylyltransferase I533_01050 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) I533_01060 ENOG4107XMK single-stranded DNA-binding protein I533_01075 ENOG4105CNT hydrolase family 2 I533_01090 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) I533_01095 ENOG4105E98 transcriptional regulator DeoR family I533_01100 ENOG4105C6V Glycerol-3-phosphate dehydrogenase I533_01150 ENOG4107QHF type ii secretion system protein e I533_01155 ENOG4105D7Q type ii secretion system I533_01200 ENOG4105DFF Rod shape-determining protein mreb I533_01205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) I533_01210 ENOG4105VQ7 Rod shape-determining protein MreD I533_01215 ENOG4108Z03 MAF-like protein I533_01220 ENOG4105C03 ribonuclease I533_01235 ENOG4105D1U peptidase U62 modulator of DNA gyrase I533_01240 ENOG4105N42 UPF0307 protein I533_01245 ENOG4105CMS peptidase U62, modulator of DNA gyrase I533_01255 ENOG4105CNT hydrolase family 2 I533_01260 ENOG41065U4 response regulator I533_01265 ENOG4105BZU Histidine kinase I533_01270 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) I533_01275 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) I533_01280 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) I533_01285 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) I533_01290 ENOG4105CEN a g-specific adenine glycosylase I533_01295 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) I533_01310 ENOG4107UNZ domain protein I533_01320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) I533_01325 ENOG4105GR3 Histidine kinase I533_01330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I533_01350 ENOG4108IJF Heavy metal efflux pump, CzcA I533_01430 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) I533_01445 ENOG4107JPU I533_01450 ENOG4108USZ hydrogenase I533_01460 ENOG4105E3S small subunit I533_01480 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) I533_01485 ENOG4107RSS Hydrogenase accessory protein HypB I533_01490 ENOG4105CQS hydrogenase expression formation protein HypD I533_01500 ENOG4105C45 hydrogenase expression formation protein (HypE) I533_01510 ENOG4105C59 p-type ATPase I533_01590 ENOG4105PGM cation diffusion facilitator family transporter I533_01600 ENOG41080IJ Diacylglycerol kinase I533_01605 ENOG4105DIJ Phosphoethanolamine transferase I533_01610 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) I533_01620 ENOG4105CKK Glycosyl transferase, family 2 I533_01705 ENOG4105C59 p-type ATPase I533_01745 ENOG4107R7I amino acid I533_01755 ENOG4105E3B Multicopper oxidase I533_01770 ENOG4105C8Q Methyl-accepting chemotaxis I533_01775 ENOG4105BZU Histidine kinase I533_01780 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) I533_01830 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) I533_01855 ENOG4105ETE Transcriptional regulator (LacI family I533_01870 ENOG4105EAA nucleoside I533_01895 ENOG4105C0A alcohol dehydrogenase I533_01900 ENOG4105CM2 brancheD-chain amino acid aminotransferase I533_01905 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) I533_01915 ENOG4107QM5 aconitate hydratase I533_01925 ENOG4107QHF type ii secretion system protein e I533_01935 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) I533_01940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) I533_01945 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) I533_01950 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity I533_01955 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) I533_01960 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) I533_01965 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) I533_01970 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) I533_01975 ENOG41083MP 50s ribosomal protein l29 I533_01980 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal I533_01985 ENOG4107RJ7 Glycosyl transferase (Group 1 I533_01995 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase I533_02015 ENOG41069D7 Methyl-accepting chemotaxis I533_02020 ENOG4105DGW oligopeptidase A I533_02040 ENOG4105CQ7 ATP-dependent helicase I533_02045 ENOG4105CVE Lytic murein transglycosylase I533_02050 ENOG4105BZ4 penicillin-binding protein I533_02065 ENOG4105CKW Inner membrane protein yedI I533_02070 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF I533_02080 ENOG4108YZA Nitrogen regulatory protein pii I533_02090 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I533_02095 ENOG4105EZR dyp-type peroxidase family protein I533_02105 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase I533_02110 ENOG4105CXT aspartate transcarbamylase I533_02135 ENOG4105BZU Histidine kinase I533_02140 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I533_02150 ENOG4105BZU Histidine kinase I533_02160 ENOG4105C26 Dehydrogenase I533_02170 ENOG4105C8Y Acetylornithine aminotransferase I533_02185 ENOG4105C31 Tryptophanyl-tRNA synthetase I533_02190 ENOG4105DJV ribulose-phosphate 3-epimerase I533_02210 ENOG4105DFE Dna adenine methylase I533_02220 ENOG4105D49 3-dehydroquinate synthase I533_02225 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) I533_02230 ENOG4105E4G Type IV pilus I533_02255 ENOG4108JQC penicillin-binding protein 1A I533_02260 ENOG4107R1I NAD-dependent malic enzyme I533_02270 ENOG4105CYM Glutathione S-transferase I533_02280 ENOG4105CH6 catalase I533_02305 ENOG4107QZM n-acetylglutamate synthase I533_02310 ENOG4105CH7 arginosuccinase I533_02315 ENOG4105CDH Citrulline--aspartate ligase I533_02325 ENOG4105CAS nag kinase I533_02330 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase I533_02335 ENOG4108Z5K methylglyoxal synthase I533_02345 ENOG4105E3W Two component transcriptional regulator (Winged helix family I533_02350 ENOG4105E0F Histidine kinase I533_02355 ENOG4108EUD Lysophospholipase I533_02360 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) I533_02370 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase I533_02375 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) I533_02380 ENOG4105VW4 glutaredoxin 3 I533_02385 ENOG4107YZP Rhodanese domain protein I533_02390 ENOG41063SB peptidase I533_02395 ENOG4105PXI polysaccharide deacetylase I533_02415 ENOG4105DJ4 phosphatidylserine decarboxylase I533_02420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) I533_02425 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) I533_02455 ENOG4105DVF Cytosine-specific methyltransferase I533_02465 ENOG4105C7K acetolactate synthase I533_02470 ENOG4108ZP8 Acetolactate synthase small subunit I533_02480 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) I533_02485 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) I533_02490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) I533_02500 ENOG4105F8V Hydrolase, tatD family I533_02510 ENOG4105D52 delta-aminolevulinic acid dehydratase I533_02515 ENOG4105C9X ppx gppa phosphatase I533_02520 ENOG4105C1J atp-dependent rna helicase I533_02525 ENOG4105K63 Thioredoxin I533_02535 ENOG4105CH2 amidohydrolase I533_02540 ENOG4105BZU Histidine kinase I533_02545 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) I533_02550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) I533_02555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit I533_02575 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I533_02585 ENOG4107QR8 Thioredoxin I533_02605 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis I533_02610 ENOG4105C26 Dehydrogenase I533_02625 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I533_02630 ENOG4107S6Z Na H antiporter I533_02645 ENOG4105EHZ conserved protein UCP016719 I533_02650 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate I533_02655 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) I533_02685 ENOG4105K3M )-transporter I533_02695 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA I533_02700 ENOG4105I4A GCN5-related N-acetyltransferase I533_02725 ENOG41084S7 Plasmid maintenance system antidote protein I533_02740 ENOG4105K4U addiction module toxin, RelE StbE family I533_02800 ENOG4105CHU acetyl-coa acetyltransferase I533_02805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I533_02810 ENOG4107SC1 transglycosylase I533_02815 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) I533_02825 ENOG4105EAH synthase I533_02830 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) I533_02835 ENOG4105K46 50S ribosomal protein l27 I533_02840 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control I533_02855 ENOG4108K5P (LipO)protein I533_02860 ENOG4108UM1 dedA family I533_02865 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) I533_02870 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) I533_02875 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) I533_02880 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) I533_02885 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) I533_02895 ENOG4105C8Q Methyl-accepting chemotaxis I533_02905 ENOG4105C26 Dehydrogenase I533_02935 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) I533_02940 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase I533_02945 ENOG4105HF0 Membrane I533_02950 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) I533_02955 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) I533_02965 ENOG4105BZU Histidine kinase I533_02985 ENOG4105D3G Pseudouridine synthase I533_02990 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) I533_03005 ENOG4108IAB Phoh family I533_03015 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I533_03020 ENOG4105C1J atp-dependent rna helicase I533_03040 ENOG4105DFG type I secretion outer membrane protein I533_03045 ENOG41087AY ADP-Ribose pyrophosphatase I533_03055 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) I533_03060 ENOG4105IPS esterase I533_03065 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I533_03075 ENOG4107VXZ Hydrolase I533_03100 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein I533_03105 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) I533_03110 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) I533_03115 ENOG4105UGU tonB-dependent Receptor I533_03125 ENOG41068WN I533_03130 ENOG4105CNM Receptor I533_03140 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I533_03145 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) I533_03155 ENOG4105M85 Bola protein I533_03185 ENOG4105CHH sulfate transporter I533_03190 ENOG4107QZF nitrite reductase NADPH large subunit I533_03205 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I533_03210 ENOG4108I0Q anthranilate phosphoribosyltransferase I533_03215 ENOG4107SDU Methyl-accepting chemotaxis I533_03230 ENOG4105D7T ABC transporter I533_03245 ENOG4108Z33 Thiol disulfide Interchange Protein I533_03250 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I533_03255 ENOG4105E27 serine threonine protein kinase I533_03260 ENOG4105C58 cytochrome c oxidase accessory protein ccog I533_03275 ENOG4105CSU acyl-Coa dehydrogenase I533_03280 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr I533_03290 ENOG4105CXK mandelate racemase muconate lactonizing I533_03295 ENOG4105MP9 class II Aldolase I533_03315 ENOG4105BZS acriflavin resistance protein I533_03330 ENOG4105C8Q Methyl-accepting chemotaxis I533_03335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I533_03340 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) I533_03345 ENOG4105KTH gatB Yqey I533_03350 ENOG4105VCC 30S ribosomal protein S21 I533_03355 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I533_03365 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) I533_03370 ENOG4107ZVW dihydroneopterin aldolase I533_03380 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) I533_03385 ENOG4105K59 histidine triad (HIT) protein I533_03400 ENOG4105DKK Benzoate I533_03405 ENOG4108JCI Transcriptional regulator I533_03410 ENOG4105DH7 May be involved in recombination (By similarity) I533_03415 ENOG4105BZU Histidine kinase I533_03420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I533_03425 ENOG4105BZU Histidine kinase I533_03460 ENOG4109015 Biopolymer transport protein exbD tolR I533_03465 ENOG41067XB TonB family I533_03475 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_03480 ENOG4105BZU Histidine kinase I533_03485 ENOG4107QIJ Aconitate hydratase 2 I533_03495 ENOG4105CFH Aspartokinase I533_03500 ENOG4108NVR Methyl-accepting chemotaxis I533_03505 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) I533_03510 ENOG4105NWN ApaG protein I533_03515 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) I533_03520 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) I533_03525 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) I533_03530 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) I533_03535 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) I533_03540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I533_03545 ENOG4105T95 Thiol disulfide interChange protein I533_03550 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) I533_03560 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) I533_03565 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) I533_03570 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) I533_03575 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) I533_03580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) I533_03585 ENOG4105DXN mazG family I533_03620 ENOG4105CEY Amp-dependent synthetase and ligase I533_03630 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) I533_03640 ENOG4105CKK Glycosyl transferase, family 2 I533_03660 ENOG4105DHQ Histidine kinase I533_03670 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) I533_03675 ENOG4108UJD 30S ribosomal protein S9 I533_03680 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) I533_03685 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) I533_03690 ENOG4105EIX cytochrome c1 I533_03695 ENOG4107MKT Stringent starvation protein a I533_03700 ENOG4105KB2 stringent starvation protein b I533_03705 ENOG4105CJW magnesium transporter I533_03710 ENOG41080Z8 PHOSPHOCARRIER protein I533_03715 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) I533_03720 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN I533_03725 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA I533_03730 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I533_03735 ENOG4108IUZ ABC transporter I533_03740 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA I533_03750 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase I533_03755 ENOG4105C2X Arabinose 5-phosphate isomerase I533_03765 ENOG4105DHJ ABC, transporter I533_03770 ENOG4105CY3 ABC transporter, permease I533_03775 ENOG4107PE3 Mammalian cell entry related domain protein I533_03780 ENOG4105E3I toluene tolerance I533_03790 ENOG4105VFK BolA family I533_03795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) I533_03800 ENOG4105C0H protease I533_03805 ENOG4105C0H protease I533_03815 ENOG4105D6Z AFG1 family ATPase I533_03820 ENOG4105CDY transcriptional regulatory protein I533_03835 ENOG4105BZU Histidine kinase I533_03840 ENOG4108RCM Nitroreductase I533_03860 ENOG4105D05 Receptor I533_03865 ENOG4108RNG Permease of the drug metabolite transporter I533_03875 ENOG4105BZU Histidine kinase I533_03895 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP I533_03900 ENOG4105CV1 Transketolase (EC 2.2.1.1) I533_03905 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I533_03910 ENOG4105BZA Phosphoglycerate kinase I533_03915 ENOG4105WYW fructose-bisphosphate aldolase I533_03925 ENOG4105C1P efflux transporter, rnd family, mfp subunit I533_03935 ENOG4105ENJ RND efflux system, outer membrane lipoprotein I533_03940 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I533_03945 ENOG4105C9X ppx gppa phosphatase I533_03960 ENOG4105C8U phosphate abc transporter I533_03970 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) I533_03980 ENOG4105CJ3 phosphate transporter I533_03990 ENOG4105C5Q Transcriptional regulator I533_04000 ENOG4108UT2 hemolysin iii I533_04005 ENOG4105K56 Transcriptional regulator I533_04010 ENOG4108ZHJ Organic hydroperoxide resistance protein I533_04080 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein I533_04090 ENOG4107RH8 nuclease SbcCD subunit D I533_04095 ENOG4105EYH Exonuclease I533_04100 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) I533_04110 ENOG4105CI2 imidazolone-5-propionate hydrolase I533_04115 ENOG4105CZE histidine utilization repressor I533_04120 ENOG4105CGP Urocanate hydratase I533_04125 ENOG4105C84 Histidine ammonia-lyase I533_04155 ENOG4105D64 Mechanosensitive ion channel I533_04205 ENOG41067MG lrgb family I533_04235 ENOG4105CSA Coproporphyrinogen iii oxidase I533_04240 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) I533_04245 ENOG4105C1J atp-dependent rna helicase I533_04255 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate I533_04280 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I533_04285 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I533_04290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I533_04295 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) I533_04305 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) I533_04310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) I533_04315 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) I533_04325 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) I533_04330 ENOG4108IUW ABC transporter I533_04335 ENOG4108SDH ABC, transporter I533_04355 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) I533_04360 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) I533_04365 ENOG41060IM Heme exporter protein I533_04370 ENOG4105X3C heme exporter protein I533_04375 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) I533_04380 ENOG4105DA4 cytochrome c-type biogenesis protein I533_04385 ENOG4107QX9 Thiol disulfide interChange protein I533_04390 ENOG4108M1T Cytochrome c-type biogenesis protein I533_04400 ENOG410903C (LipO)protein I533_04405 ENOG4105CMR udp-glucose 4-epimerase I533_04415 ENOG4105DUX Transporter I533_04445 ENOG4105ESV Glycosyl transferase, family 4 I533_04460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase I533_04465 ENOG4105KQC Competence protein I533_04470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I533_04485 ENOG4105EWT decarboxylase family I533_04490 ENOG4105BZU Histidine kinase I533_04495 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) I533_04500 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) I533_04535 ENOG4105DR9 pseudouridine synthase I533_04540 ENOG4105QDK Flavodoxin I533_04545 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) I533_04550 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) I533_04555 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) I533_04560 ENOG4105CE9 30S ribosomal protein S2 I533_04565 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) I533_04570 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) I533_04575 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) I533_04580 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) I533_04585 ENOG4105KNE Phosphatidate cytidylyltransferase I533_04590 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) I533_04600 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane I533_04605 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) I533_04610 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) I533_04615 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I533_04620 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I533_04625 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I533_04630 ENOG4105C0B DNA polymerase III (alpha subunit) I533_04635 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) I533_04640 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) I533_04645 ENOG4105BZU Histidine kinase I533_04660 ENOG4108Z6B deaminase I533_04670 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) I533_04675 ENOG4108ETH Formylglycinamide ribotide synthetase I533_04685 ENOG4108DG9 Smr protein MutS2 I533_04720 ENOG4105CDV Ompa motb domain protein I533_04725 ENOG4108JJA ABC, transporter I533_04735 ENOG4105WH1 Two component transcriptional regulator luxr family I533_04775 ENOG4107R88 Chemotaxis protein (CheV) I533_04780 ENOG4105BZU Histidine kinase I533_04785 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) I533_04790 ENOG4108ZC9 flagellar basal-body rod protein flgc I533_04795 ENOG4105W00 Flagellar hook capping protein I533_04800 ENOG4105BZE flagellar hook protein, FlgE I533_04805 ENOG4108KPB Flagellar basal-body rod protein FlgF I533_04810 ENOG4105CGA flagellar basal-body rod protein FlgG I533_04815 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) I533_04820 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) I533_04825 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj I533_04830 ENOG4105E1Q flagellar hook-associated protein I533_04850 ENOG4105I03 Flagellin I533_04855 ENOG4105I03 Flagellin I533_04860 ENOG41063QE flagellar protein FlaG I533_04870 ENOG4105MQ3 flagellar protein FliS I533_04885 ENOG4105CHR reductase I533_04890 ENOG4105CEY Amp-dependent synthetase and ligase I533_04915 ENOG4105F0R Cytidylyltransferase I533_04920 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase I533_04925 ENOG4105C5E polysaccharide biosynthesis protein I533_04930 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase I533_04935 ENOG4105I03 Flagellin I533_04940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_04945 ENOG4105BZU Histidine kinase I533_04950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_04955 ENOG4105VQ0 flagellar hook-basal body complex protein fliE I533_04960 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) I533_04965 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I533_04975 ENOG4108JIR Flagellum-specific ATP synthase I533_04995 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I533_05000 ENOG4105DD5 Flagellar motor switch protein I533_05005 ENOG4105VTB flagellar biosynthesis protein fliO I533_05010 ENOG4105CN7 Flagellar biosynthetic protein FliP I533_05015 ENOG4105VS8 Flagellar biosynthetic protein fliq I533_05020 ENOG4105D19 Role in flagellar biosynthesis (By similarity) I533_05025 ENOG4105D00 flagellar biosynthetic protein flhB I533_05030 ENOG4105D7B Flagellar biosynthesis protein flha I533_05035 ENOG4105FZW flagellar biosynthesis regulator FlhF I533_05045 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I533_05050 ENOG4108VYJ response regulator receiver protein I533_05055 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) I533_05060 ENOG4105CBS Chea signal transduction histidine kinase I533_05070 ENOG4107QJE Chromosome Partitioning Protein I533_05080 ENOG4105YFD chemotaxis, protein I533_05090 ENOG4105CVG Homoserine O-transsuccinylase I533_05095 ENOG4105C3R Methionine synthase I533_05100 ENOG4105C3R Methionine synthase I533_05110 ENOG4105NBK UPF0345 protein I533_05115 ENOG4105C8Q Methyl-accepting chemotaxis I533_05120 ENOG4105DZ2 Transcriptional regulator I533_05125 ENOG4105C5Q Transcriptional regulator I533_05130 ENOG4107B2H carbonic anhydrase I533_05135 ENOG4105CHH sulfate transporter I533_05150 ENOG4105C9K Endothelin-converting enzyme 1 I533_05160 ENOG4108004 Modulates RecA activity (By similarity) I533_05165 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) I533_05170 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) I533_05185 ENOG4107QSA Oxaloacetate decarboxylase I533_05190 ENOG4105D9Q decarboxylase (Beta subunit) I533_05195 ENOG4108JQ2 peptide transport system atp-binding protein I533_05200 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein I533_05205 ENOG4108EU3 peptide transport system, permease I533_05210 ENOG4108I5W peptide transport system, permease protein I533_05215 ENOG4105DEF Extracellular solute-binding protein, family 5 I533_05220 ENOG4105E51 psp operon transcriptional activator I533_05235 ENOG4108RXX maleylacetoacetate isomerase I533_05240 ENOG4108XM1 transcriptional regulator AsnC family I533_05260 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) I533_05265 ENOG4108KPZ tonB-dependent Receptor I533_05315 ENOG4109015 Biopolymer transport protein exbD tolR I533_05320 ENOG410822N TonB family I533_05330 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) I533_05365 ENOG4105HEI LysR family (Transcriptional regulator I533_05370 ENOG4105F27 Major Facilitator I533_05375 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) I533_05380 ENOG4105CV8 reductase I533_05400 ENOG4107MII Sugar-specific transcriptional regulator TrmB I533_05425 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I533_05455 ENOG4105KT5 UmuD protein I533_05480 ENOG4105CVR type I restriction-modification system I533_05495 ENOG4105DZR Type I site-specific deoxyribonuclease I533_05500 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 I533_05545 ENOG4105D70 Integrase catalytic subunit I533_05555 ENOG4105F5W AtP-binding protein I533_05610 ENOG4105T95 Thiol disulfide interChange protein I533_05665 ENOG4108UUM single-stranded DNA-binding protein I533_05685 ENOG4105GMT ATPase associated with various cellular activities aaa_5 I533_05710 ENOG4108YGG dna repair protein I533_05800 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) I533_05805 ENOG4105C75 arginyL-tRNA synthetase I533_05890 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) I533_05895 ENOG4105C75 arginyL-tRNA synthetase I533_05925 ENOG4105BZU Histidine kinase I533_05930 ENOG4108KBJ Inner membrane protein YkgB I533_05965 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) I533_05970 ENOG4105CRK lysyL-tRNA synthetase I533_05975 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) I533_05980 ENOG4108W1A pseudouridine synthase I533_05995 ENOG4105D9M gamma-glutamylcysteine synthetase I533_06020 ENOG4108DG9 Smr protein MutS2 I533_06025 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) I533_06030 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase I533_06040 ENOG4105ED1 spovr family I533_06045 ENOG4106AKX UPF0229 protein I533_06050 ENOG4105CYN Serine protein kinase I533_06055 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I533_06060 ENOG4105M2J Glutaredoxin I533_06065 ENOG4105D05 Receptor I533_06090 ENOG4105D3R alkyl hydroperoxide reductase I533_06095 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) I533_06100 ENOG4105EIY sodium-type flagellar protein motY I533_06105 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase I533_06110 ENOG4108UYE Lactoylglutathione lyase I533_06115 ENOG4105VEQ Cold shock protein I533_06140 ENOG4105DZB Electron transport complex I533_06145 ENOG4108UQQ Electron transport complex I533_06150 ENOG4105D6A Electron transport complex I533_06160 ENOG4108R3D Electron transport complex I533_06165 ENOG4105DGN Electron transport complex I533_06170 ENOG4107QJQ Mate efflux family protein I533_06175 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) I533_06185 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) I533_06190 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) I533_06200 ENOG4105CAQ asparagine synthetase I533_06230 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) I533_06235 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase I533_06240 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) I533_06245 ENOG4105C11 sulfate adenylyltransferase), subunit 2 I533_06250 ENOG4105CK7 Sodium proline symporter I533_06255 ENOG4105BZU Histidine kinase I533_06280 ENOG4107QVM von Willebrand factor, type A I533_06300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I533_06305 ENOG4105CHU acetyl-coa acetyltransferase I533_06310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I533_06325 ENOG4105BZU Histidine kinase I533_06335 ENOG4108BY2 phosphohistidine phosphatase I533_06345 ENOG4108JU6 CBS domain protein I533_06350 ENOG4106KVJ cytochrome C assembly protein I533_06355 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY I533_06405 ENOG4105ENT Efflux transporter rnd family, mfp subunit I533_06410 ENOG4105BZ1 (ABC) transporter I533_06425 ENOG4105K5M 30s ribosomal protein S16 I533_06430 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) I533_06435 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) I533_06440 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) I533_06445 ENOG4105EN6 Membrane I533_06450 ENOG4105E39 Enoyl-CoA hydratase I533_06455 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) I533_06475 ENOG4108ZJT translation initiation factor, Sui1 I533_06485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I533_06495 ENOG4105BZU Histidine kinase I533_06505 ENOG4107WP9 Histidine kinase I533_06515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_06520 ENOG4105I03 Flagellin I533_06535 ENOG4105C9M aspartyl-trna synthetase I533_06540 ENOG4108TIT dATP pyrophosphohydrolase I533_06545 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) I533_06550 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) I533_06555 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) I533_06560 ENOG4107YD3 Thioesterase I533_06565 ENOG4105E02 MotA TolQ exbB proton channel I533_06570 ENOG4105M8F Biopolymer transport protein exbD tolR I533_06580 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) I533_06585 ENOG4105KCK Peptidoglycan-associated lipoprotein I533_06590 ENOG4105UFD tol-pal system protein YbgF I533_06595 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) I533_06605 ENOG4108NRW Phospholipase, patatin family I533_06610 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) I533_06640 ENOG4108VHC Short-chain dehydrogenase reductase Sdr I533_06645 ENOG4105DS1 cytochrome b561 I533_06650 ENOG4105BZU Histidine kinase I533_06665 ENOG4105HEI LysR family (Transcriptional regulator I533_06670 ENOG4108VKG metal-dependent hydrolase I533_06680 ENOG4105BZS acriflavin resistance protein I533_06690 ENOG4105BZU Histidine kinase I533_06700 ENOG4105DY2 Paraquat-inducible protein b I533_06705 ENOG4105F1S paraquat-inducible protein a I533_06720 ENOG4105C5S asparaginyl-tRNA synthetase I533_06735 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I533_06755 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) I533_06760 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) I533_06765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I533_06770 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I533_06775 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) I533_06780 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) I533_06785 ENOG4105KJF protein tyrosine phosphatase I533_06790 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) I533_06795 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) I533_06800 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase I533_06815 ENOG4108JJ7 ABC transporter I533_06820 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) I533_06830 ENOG4105XJC Two component transcriptional regulator (Winged helix family I533_06835 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) I533_06845 ENOG4108UJV acyl-CoA thioesterase i I533_06850 ENOG4108I0Y (ABC) transporter I533_06855 ENOG4105CV6 ABC transporter, permease I533_06860 ENOG4105ECP epimerase I533_06865 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase I533_06870 ENOG4105DSF transport protein I533_06880 ENOG4105XJC Two component transcriptional regulator (Winged helix family I533_06895 ENOG4105K9H YciI-like protein I533_06900 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) I533_06905 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) I533_06910 ENOG4105DK0 Indole-3-glycerol phosphate synthase I533_06915 ENOG4108I0Q anthranilate phosphoribosyltransferase I533_06925 ENOG4105CRQ synthase (Component I) I533_06930 ENOG4105DB7 PHP domain protein I533_06935 ENOG4107RTD sua5 ycio yrdc ywlc family protein I533_06940 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) I533_06945 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) I533_06950 ENOG4105FE9 pseudouridine synthase I533_06955 ENOG4105CV8 reductase I533_06960 ENOG4108UW5 maltose o-acetyltransferase I533_06970 ENOG4106BRA Membrane I533_06975 ENOG4105FQ6 thiopurine methyltransferase I533_06980 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I533_06985 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) I533_06990 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction I533_06995 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) I533_07000 ENOG4105C0A alcohol dehydrogenase I533_07005 ENOG4105DTD Dehydrogenase I533_07015 ENOG4105DWV Homoserine O-trans-acetylase I533_07020 ENOG4105CY2 Citrate transporter I533_07035 ENOG4105BZU Histidine kinase I533_07040 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ I533_07045 ENOG4105CFG Acts as a chaperone (By similarity) I533_07050 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) I533_07055 ENOG41085AF Cytochrome I533_07060 ENOG4108M8H domain protein I533_07065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) I533_07075 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) I533_07080 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain I533_07085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain I533_07090 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) I533_07095 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) I533_07100 ENOG4105C6K Malic enzyme I533_07115 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) I533_07120 ENOG4108JU5 Magnesium and cobalt efflux protein I533_07125 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) I533_07130 ENOG4105C9A Phoh family I533_07135 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) I533_07140 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family I533_07180 ENOG4107RNH Outer membrane receptor FepA I533_07185 ENOG4108S4H thioesterase Superfamily protein I533_07190 ENOG4107XWI flavin reductase domain protein, FMN-binding I533_07205 ENOG4105BZG amino acid carrier protein I533_07210 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I533_07215 ENOG4105C3G gtp-binding protein I533_07220 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) I533_07230 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) I533_07235 ENOG4105DQ4 alcohol dehydrogenase I533_07250 ENOG4105C5T Phosphoribosyl pyrophosphate synthase I533_07255 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) I533_07260 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) I533_07265 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) I533_07270 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) I533_07275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) I533_07280 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_07285 ENOG4108YY7 Invasion gene expression up-regulator SirB I533_07290 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase I533_07300 ENOG4105ETT transcriptional Regulator, LysR family I533_07310 ENOG4105M08 Membrane I533_07315 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) I533_07320 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) I533_07325 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) I533_07330 ENOG4107TPY serine threonine protein kinase I533_07335 ENOG4105TMB Formate nitrite transporter I533_07340 ENOG4105F8C transglutaminase domain-containing protein I533_07350 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I533_07355 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) I533_07360 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 I533_07365 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) I533_07370 ENOG4105BZU Histidine kinase I533_07375 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) I533_07385 ENOG4105K8R UPF0145 protein I533_07405 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) I533_07410 ENOG4105KUZ arsenate reductase I533_07415 ENOG4107RBJ symporter I533_07435 ENOG4105F1J Homogentisate 1,2-dioxygenase I533_07450 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) I533_07460 ENOG4105BZU Histidine kinase I533_07465 ENOG4105BZU Histidine kinase I533_07470 ENOG4105BZS acriflavin resistance protein I533_07485 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein I533_07510 ENOG4105BZU Histidine kinase I533_07520 ENOG4107QUY Guanine deaminase I533_07540 ENOG4105C7W Xanthine dehydrogenase I533_07550 ENOG4108R86 Transcriptional regulator I533_07565 ENOG4105C7N Xanthine uracil vitamin C permease I533_07570 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) I533_07580 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_07595 ENOG4105BZU Histidine kinase I533_07610 ENOG4105C2W permease I533_07625 ENOG4105C5R Aminotransferase I533_07630 ENOG4105HF0 Membrane I533_07635 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I533_07675 ENOG4105K6S Short-chain dehydrogenase reductase Sdr I533_07685 ENOG4105C22 threonyL-tRNA synthetase I533_07690 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) I533_07695 ENOG41082NX 50s ribosomal protein l35 I533_07700 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) I533_07720 ENOG4108ESX Receptor I533_07725 ENOG4105D3Q Sugar transferase I533_07740 ENOG4105D75 Capsular exopolysaccharide family I533_07745 ENOG4108RB3 Capsular polysaccharide biosynthesis protein I533_07780 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family I533_07785 ENOG4105CG5 Glycosyl transferase (Group 1 I533_07790 ENOG4105CG5 Glycosyl transferase (Group 1 I533_07825 ENOG4105F2I Transposase I533_07840 ENOG4105EXC Acyl-transferase I533_07845 ENOG4105D3Q Sugar transferase I533_07850 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase I533_07855 ENOG4105FAW cDP-glucose 4,6-dehydratase I533_07880 ENOG4108XG4 DNA-binding transcriptional regulator I533_07885 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) I533_07890 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) I533_07895 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) I533_07910 ENOG4108Z66 YbaK ebsC protein I533_07920 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) I533_07925 ENOG4108WBT adenosyltransferase I533_07935 ENOG4108JA2 transcriptioN-repair coupling factor I533_07945 ENOG4105D60 lipoprotein releasing system transmembrane protein I533_07970 ENOG4105CGK Exodeoxyribonuclease III I533_08005 ENOG4105DNH Major Facilitator I533_08015 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) I533_08040 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase I533_08050 ENOG4108UKI Enoyl-CoA hydratase I533_08055 ENOG4107QX3 carboxylase I533_08060 ENOG4105C1G acyl-Coa dehydrogenase I533_08065 ENOG4108Z6Z Transcriptional regulator I533_08070 ENOG4105CHU acetyl-coa acetyltransferase I533_08085 ENOG4105BZU Histidine kinase I533_08095 ENOG4105CJB Exodeoxyribonuclease I I533_08100 ENOG4105BZU Histidine kinase I533_08105 ENOG4105D44 asparaginase I533_08150 ENOG4105CQ7 ATP-dependent helicase I533_08165 ENOG4105DR4 Methyltransferase I533_08170 ENOG4108JA1 polyketide synthase I533_08175 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I533_08180 ENOG4107RZZ dna polymerase iii epsilon subunit I533_08190 ENOG4108M8H domain protein I533_08200 ENOG4105D60 lipoprotein releasing system transmembrane protein I533_08215 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) I533_08225 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) I533_08250 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) I533_08255 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) I533_08260 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit I533_08265 ENOG4107YB6 acetyltransferase, (GNAT) family I533_08280 ENOG4105C03 ribonuclease I533_08285 ENOG4105EI2 Pseudouridine synthase I533_08295 ENOG4108UHJ MAF-like protein I533_08300 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein I533_08305 ENOG4105VGS 50s ribosomal protein l32 I533_08310 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) I533_08315 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) I533_08320 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase I533_08325 ENOG4105CHR reductase I533_08330 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) I533_08335 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) I533_08345 ENOG4105HHA aminodeoxychorismate lyase I533_08350 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) I533_08355 ENOG4107QRG dna polymerase iii I533_08360 ENOG4105F8V Hydrolase, tatD family I533_08375 ENOG4105BZU Histidine kinase I533_08395 ENOG4105CHR reductase I533_08400 ENOG4108J2P Alpha beta hydrolase fold I533_08410 ENOG4105CHU acetyl-coa acetyltransferase I533_08415 ENOG4105CSU acyl-Coa dehydrogenase I533_08430 ENOG4105DKT Transcriptional regulator I533_08435 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 I533_08445 ENOG4105DEI Mannitol dehydrogenase I533_08470 ENOG4105D8X mechanosensitive ion channel I533_08475 ENOG4105D05 Receptor I533_08480 ENOG4105KZX Pterin carbinolamine dehydratase I533_08485 ENOG4105BZU Histidine kinase I533_08490 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_08495 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) I533_08500 ENOG4105CHV Transcription elongation factor NusA I533_08505 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) I533_08510 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) I533_08515 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) I533_08525 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) I533_08530 ENOG4105FE9 pseudouridine synthase I533_08540 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase I533_08580 ENOG4105D3R alkyl hydroperoxide reductase I533_08625 ENOG4105CCT upf0313 protein I533_08645 ENOG4107QN2 dihydrolipoyl dehydrogenase I533_08655 ENOG4105VNH ABC transporter solute-binding protein I533_08665 ENOG4108VGW abc transporter atp-binding protein I533_08670 ENOG4108T9J Cdp-alcohol phosphatidyltransferase I533_08715 ENOG4105W7K Transcriptional regulator I533_08740 ENOG4105CJ1 ABC, transporter I533_08755 ENOG4105DMT epimerase dehydratase I533_08760 ENOG4105C09 Bile acid I533_08780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I533_08785 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) I533_08790 ENOG4108Z1B Cyclase dehydrase I533_08795 ENOG4105VDB UPF0125 protein I533_08805 ENOG4105C94 Transporter I533_08815 ENOG4107RDJ Sulfotransferase I533_08825 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) I533_08830 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) I533_08870 ENOG4105EZE Cupin 4 family protein I533_08880 ENOG4107QTF adenylosuccinate lyase I533_08885 ENOG41075W9 High frequency lysogenization protein HflD homolog I533_08890 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) I533_08895 ENOG4108R99 pseudouridine synthase I533_08905 ENOG4105VEQ Cold shock protein I533_08910 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) I533_08915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit I533_08920 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) I533_08925 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate I533_08930 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) I533_08935 ENOG4105C3M thioredoxin reductase I533_08940 ENOG4105PQ6 UPF0208 membrane protein I533_08945 ENOG4105GPY SprT protein I533_08950 ENOG4105D07 Signal peptide peptidase, SppA I533_08965 ENOG41069NU Nitroreductase I533_08975 ENOG4105HDK L-asparaginase I533_08980 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) I533_08985 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) I533_08990 ENOG4108Z43 UPF0250 protein I533_08995 ENOG4105DZ1 carboxypeptidase I533_09000 ENOG4105K6T rare lipoprotein A I533_09005 ENOG4105CNI cell division protein FtsW I533_09010 ENOG4105CJN penicillin-binding protein I533_09015 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) I533_09020 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) I533_09030 ENOG4105DJF DNA polymerase III, delta' subunit I533_09035 ENOG4108U2H Rare lipoprotein B I533_09040 ENOG4105C8T Leucyl-tRNA synthetase I533_09055 ENOG4105DAN ATP-dependent protease I533_09060 ENOG4107R6F Alpha Beta Hydrolase Fold protein I533_09065 ENOG4105BZU Histidine kinase I533_09075 ENOG4105HBR Rna-binding protein I533_09080 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) I533_09085 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) I533_09090 ENOG4105EEI dihydropteroate synthase I533_09095 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) I533_09100 ENOG4105CP7 Triose-phosphate isomerase I533_09120 ENOG4105CHR reductase I533_09125 ENOG4108KP7 hydrolase I533_09140 ENOG4105CK7 Sodium proline symporter I533_09150 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) I533_09165 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) I533_09205 ENOG4105M03 Domain of unknown function (DUF955) I533_09315 ENOG410822N TonB family I533_09345 ENOG4105EXN Sulfate transport protein CysZ I533_09350 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) I533_09355 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) I533_09360 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) I533_09375 ENOG4105BZ1 (ABC) transporter I533_09380 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) I533_09385 ENOG4105W49 UPF0434 protein I533_09390 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) I533_09400 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) I533_09415 ENOG4105CUZ uba thif-type nad fad binding protein I533_09420 ENOG4105CHF Glutathione S-transferase I533_09425 ENOG4105EUB pirin domain protein I533_09430 ENOG4107QKV phosphomannomutase I533_09440 ENOG4105BZN citrate synthase I533_09445 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit I533_09450 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein I533_09455 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) I533_09460 ENOG4105E33 succinate dehydrogenase I533_09465 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 I533_09470 ENOG4105C7S Dehydrogenase I533_09475 ENOG4105CMV Succinyl-CoA synthetase subunit beta I533_09480 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha I533_09490 ENOG4105QV4 Tryptophan halogenase I533_09505 ENOG4108NRW Phospholipase, patatin family I533_09525 ENOG4108IUK alpha amylase, catalytic I533_09540 ENOG4105ETE Transcriptional regulator (LacI family I533_09545 ENOG4105CX6 glutaminyL-tRNA synthetase I533_09550 ENOG4105UBK short-chain dehydrogenase reductase I533_09555 ENOG4108M0H Extracellular lipase I533_09560 ENOG4107SQI penicillin amidase I533_09565 ENOG4105ERU peptidase I533_09580 ENOG4107QNR UPF0135 protein I533_09585 ENOG4106371 Methyltransferase I533_09590 ENOG4105C5I Dehydrogenase I533_09595 ENOG4108V06 Glutathione peroxidase I533_09600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase I533_09610 ENOG4105C1G acyl-Coa dehydrogenase I533_09615 ENOG4105E39 Enoyl-CoA hydratase I533_09625 ENOG4105DHI Methyltransferase I533_09630 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase I533_09635 ENOG4105E68 Sulfatase I533_09640 ENOG4105YDX UPF0352 protein I533_09645 ENOG4106V8H Nucleoid-associated protein I533_09675 ENOG4108HRK Histidine kinase I533_09680 ENOG4108VAC response regulator I533_09685 ENOG4105CTQ phosphohexokinase I533_09710 ENOG4105CPQ Dehydrogenase I533_09720 ENOG4105EMU Dehydrogenase I533_09725 ENOG4105EJC lysr family transcriptional regulator I533_09775 ENOG4105BZU Histidine kinase I533_09785 ENOG4105C72 UPF0176 protein I533_09795 ENOG4105C1J atp-dependent rna helicase I533_09805 ENOG4105D6N CoA-transferase, subunit a I533_09810 ENOG4105F04 LysR family Transcriptional regulator I533_09825 ENOG4107R11 Transcriptional regulator I533_09830 ENOG4105EJQ L-serine dehydratase I533_09840 ENOG4105CRQ synthase (Component I) I533_09855 ENOG4105CGY Dna recombination protein I533_09860 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin I533_09870 ENOG4105CPP Dehydrogenase, E1 component I533_09880 ENOG4105D6S protein involved in catabolism of external DNA I533_09890 ENOG4105C29 acyl-CoA thioesterase I533_09895 ENOG4108Z0R Transferase I533_09900 ENOG4105C5R Aminotransferase I533_09910 ENOG4108ZGC gaf domain protein I533_09920 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) I533_09925 ENOG4105CN1 protease I533_09930 ENOG4105C8J )-transporter I533_09935 ENOG4105DFD Na H antiporter I533_09940 ENOG4105CD8 aminopeptidase N I533_09955 ENOG4105D25 secreted protein I533_09970 ENOG4105C7I Dehydrogenase I533_09975 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) I533_09980 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) I533_09990 ENOG4105C5H ABC transporter I533_10000 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) I533_10005 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) I533_10015 ENOG4105CVP deoxyribo-dipyrimidine photolyase I533_10020 ENOG4105CVP deoxyribo-dipyrimidine photolyase I533_10025 ENOG4105CVP deoxyribo-dipyrimidine photolyase I533_10030 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein I533_10045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I533_10055 ENOG41080IJ Diacylglycerol kinase I533_10060 ENOG41081QV Universal stress protein I533_10070 ENOG4105CBC glutamate synthase I533_10075 ENOG4105CKD glutathione-regulated potassium-efflux system protein I533_10080 ENOG4108UQY Iron-storage protein I533_10095 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i I533_10110 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) I533_10120 ENOG4105C59 p-type ATPase I533_10135 ENOG4105DS0 Transcriptional regulator, Crp Fnr family I533_10140 ENOG4105Q9Y Universal stress protein I533_10145 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) I533_10150 ENOG4105D78 K07001 NTE family protein I533_10170 ENOG4105CCF Lysine exporter protein (Lyse ygga) I533_10175 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) I533_10180 ENOG4105KHC sulfurtransferase I533_10185 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) I533_10190 ENOG4106IUH DTW domain containing protein I533_10200 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) I533_10205 ENOG4105WH1 Two component transcriptional regulator luxr family I533_10210 ENOG4105CHM Aminotransferase I533_10215 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process I533_10245 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) I533_10300 ENOG4108VGI doxx family I533_10305 ENOG4105CC0 LysR family Transcriptional regulator I533_10320 ENOG4108MN8 Membrane I533_10325 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) I533_10340 ENOG4108Z0T Part of a sulfur-relay system (By similarity) I533_10355 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) I533_10360 ENOG4105WMR Protein CrcB homolog I533_10365 ENOG4105D1H recombination factor protein RarA I533_10375 ENOG4105CNU cell division protein FtsK I533_10380 ENOG4105EW9 transcriptional regulator AsnC family I533_10385 ENOG4105DCF alanine dehydrogenase I533_10390 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) I533_10395 ENOG4105CFV Tetratricopeptide repeat protein I533_10410 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) I533_10415 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) I533_10420 ENOG4105CAT Cytidine monophosphate kinase I533_10425 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase I533_10430 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) I533_10435 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I533_10440 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I533_10445 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I533_10450 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I533_10455 ENOG4105XPH Ferredoxin I533_10475 ENOG4105BZU Histidine kinase I533_10485 ENOG4105EKQ RNA-directed DNA polymerase I533_10490 ENOG4105C8V SAICAR synthetase I533_10495 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I533_10500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) I533_10510 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I533_10520 ENOG4105ERG peptidase m48, ste24p I533_10530 ENOG4105K89 arsenate reductase I533_10535 ENOG4105CS1 NAD(P)H quinone oxidoreductase I533_10545 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) I533_10555 ENOG4105CXB phosphoribosylaminoimidazole synthetase I533_10560 ENOG4108V3E phosphoribosylglycinamide formyltransferase I533_10570 ENOG4107QPN acyl-Coa dehydrogenase I533_10585 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) I533_10590 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) I533_10595 ENOG4105DBI uridine monophosphokinase I533_10600 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase I533_10605 ENOG4105C3Q Glycosyl transferase, family 2 I533_10610 ENOG4107QW3 Sucrose phosphorylase I533_10615 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) I533_10620 ENOG4105CVM Molybdenum cofactor synthesis domain protein I533_10625 ENOG4107QI1 Mate efflux family protein I533_10645 ENOG4105C6T cysteine synthase I533_10685 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system I533_10725 ENOG4105JAB phenazine biosynthesis protein, phzf family I533_10730 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I533_10735 ENOG41060WC Enoyl-CoA hydratase I533_10755 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) I533_10765 ENOG4105C28 cystathionine I533_10780 ENOG4105CGF Aromatic amino acid aminotransferase I533_10795 ENOG4108UPT UPF0178 protein I533_10800 ENOG4105CHR reductase I533_10805 ENOG4105CHR reductase I533_10810 ENOG4105CSU acyl-Coa dehydrogenase I533_10815 ENOG4105FTV AraC Family Transcriptional Regulator I533_10840 ENOG4105ENT Efflux transporter rnd family, mfp subunit I533_10850 ENOG4105C10 Electron transfer flavoprotein I533_10855 ENOG4105BZJ Electron transfer flavoprotein I533_10860 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase I533_10865 ENOG4108YX2 DNA-binding protein I533_10870 ENOG4105EV9 Alpha Beta Hydrolase I533_10880 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) I533_10905 ENOG4105CHB tonB-dependent Receptor I533_10910 ENOG4108NVR Methyl-accepting chemotaxis I533_10915 ENOG41090R7 Ferric uptake I533_10930 ENOG4105P4J Allophanate hydrolase, subunit 1 I533_10935 ENOG4105E7W lamb ycsf family protein I533_10940 ENOG4105QNR S1 RNA binding domain protein I533_10945 ENOG4108UKZ OsmC family I533_10950 ENOG4105ENT Efflux transporter rnd family, mfp subunit I533_10975 ENOG4105CHM Aminotransferase I533_10980 ENOG4105DK2 UPF0207 protein I533_10985 ENOG4105DK2 UPF0207 protein I533_10995 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding I533_11025 ENOG4105ENX hydrolase I533_11030 ENOG4105CF7 AraC family transcriptional regulator I533_11045 ENOG4105DK2 UPF0207 protein I533_11050 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein I533_11075 ENOG4105K5B UPF0225 protein I533_11085 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein I533_11095 ENOG4105C1G acyl-Coa dehydrogenase I533_11105 ENOG4107ZSV Receptor I533_11125 ENOG4105D4P Coproporphyrinogen iii oxidase I533_11130 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) I533_11135 ENOG4105E0C molybdate abc transporter I533_11145 ENOG4108ZAF Molybdopterin I533_11150 ENOG4105M00 molybdopterin converting factor, subunit 1 I533_11155 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) I533_11160 ENOG4108RIR Molybdenum cofactor biosynthesis protein I533_11165 ENOG4105D06 uba thif-type nad fad binding protein I533_11180 ENOG4105KRQ Addiction module toxin, Txe YoeB family I533_11200 ENOG4105EG6 Saccharopine dehydrogenase I533_11205 ENOG4105CIH Imidazole acetol-phosphate transaminase I533_11225 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I533_11235 ENOG4107AQZ Membrane I533_11250 ENOG4107QYX exodeoxyribonuclease v alpha I533_11255 ENOG4107QKA exodeoxyribonuclease V beta I533_11260 ENOG4105DSY exodeoxyribonuclease V, gamma I533_11280 ENOG4108IQE Amp-dependent synthetase and ligase I533_11305 ENOG4105CVI Transcriptional regulator I533_11325 ENOG41082SX arsR family transcriptional regulator I533_11335 ENOG4105DUM transcriptional regulator, lysR family I533_11345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_11390 ENOG4105DK2 UPF0207 protein I533_11415 ENOG4105VUT cytoplasmic protein I533_11430 ENOG4105BZG amino acid carrier protein I533_11450 ENOG4105E0X reductase I533_11455 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) I533_11465 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) I533_11470 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) I533_11475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I533_11480 ENOG4105DSB aldose 1-epimerase I533_11485 ENOG4108UHU Aldolase I533_11490 ENOG4105CHC glucokinase (EC 2.7.1.2) I533_11495 ENOG4105C01 Dihydroxy-acid dehydratase I533_11500 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I533_11505 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I533_11510 ENOG4106KNT transcriptional regulator I533_11515 ENOG4105CA9 Pyruvate kinase I533_11530 ENOG4105CSU acyl-Coa dehydrogenase I533_11535 ENOG4105BZJ Electron transfer flavoprotein I533_11540 ENOG4105C10 Electron transfer flavoprotein I533_11545 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase I533_11550 ENOG4107QWE )-transporter I533_11570 ENOG4105CHC glucokinase (EC 2.7.1.2) I533_11575 ENOG4105C01 Dihydroxy-acid dehydratase I533_11580 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I533_11585 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I533_11590 ENOG4106KNT transcriptional regulator I533_11595 ENOG4105CA9 Pyruvate kinase I533_11600 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I533_11620 ENOG4105K3G Periplasmic Protein I533_11645 ENOG4105EIG urea carboxylase-associated protein 1 I533_11680 ENOG4108K8S endonuclease I I533_11685 ENOG4105C8Q Methyl-accepting chemotaxis I533_11700 ENOG4108W5M transcriptional regulator I533_11705 ENOG4108I6A alcohol dehydrogenase I533_11710 ENOG4105BZU Histidine kinase I533_11720 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_11725 ENOG4105BZU Histidine kinase I533_11735 ENOG4105C8P )-transporter I533_11740 ENOG4105DHP deoxycytidine triphosphate deaminase I533_11745 ENOG4105D1F ATP-binding protein I533_11750 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) I533_11760 ENOG4105D1A Methyltransferase I533_11765 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) I533_11770 ENOG4105E9H Lytic Murein transglycosylase I533_11780 ENOG4105C8N cysteinyl-tRNA synthetase I533_11785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I533_11790 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) I533_11800 ENOG4107S78 Band 7 protein I533_11815 ENOG4105KVH Transcriptional regulator I533_11830 ENOG4105CIS alcohol dehydrogenase I533_11860 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase I533_11870 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase I533_11875 ENOG4105E96 Colicin v production protein I533_11880 ENOG4108S3P Sporulation domain protein I533_11885 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase I533_11890 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) I533_11905 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) I533_11910 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) I533_11915 ENOG4105MP9 class II Aldolase I533_11930 ENOG4105YAJ CopG Arc MetJ I533_11940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) I533_11950 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) I533_11970 ENOG4108Z7F N-acetyltransferase I533_11995 ENOG4108Z6Z Transcriptional regulator I533_12000 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family I533_12020 ENOG4105DKW ABC transporter I533_12025 ENOG4105CRW Short chain fatty acid transporter I533_12030 ENOG4105BZU Histidine kinase I533_12055 ENOG4108BPE -transporting atpase I533_12080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I533_12105 ENOG4105D8T Acyltransferase I533_12115 ENOG4108UH6 UPF0754 membrane protein I533_12140 ENOG4105CUG Oligopeptidase b I533_12145 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) I533_12150 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) I533_12155 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) I533_12160 ENOG4108428 Inherit from COG: -acetyltransferase I533_12170 ENOG4108ZZ3 UPF0260 protein I533_12175 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase I533_12185 ENOG4105VNG YcgL domain-containing protein I533_12190 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) I533_12195 ENOG4105CEY Amp-dependent synthetase and ligase I533_12200 ENOG410832A alpha/beta hydrolase fold I533_12215 ENOG41072GX Peptidase M22 Glycoprotease I533_12220 ENOG4105DVT helicase I533_12270 ENOG4105D05 Receptor I533_12280 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) I533_12285 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) I533_12290 ENOG4105CIH Imidazole acetol-phosphate transaminase I533_12295 ENOG4105ECC imidazole-glycerol-phosphate dehydratase I533_12300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) I533_12305 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase I533_12310 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) I533_12315 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase I533_12320 ENOG4105S64 Formate nitrite transporter I533_12325 ENOG4105C8Q Methyl-accepting chemotaxis I533_12355 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) I533_12360 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) I533_12365 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) I533_12375 ENOG4105BZU Histidine kinase I533_12380 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) I533_12385 ENOG4107QMP dna polymerase iii subunits gamma and tau I533_12390 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) I533_12400 ENOG4105E18 UPF0276 protein I533_12410 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) I533_12430 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase I533_12450 ENOG4105CXG d-lactate dehydrogenase I533_12455 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit I533_12460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase I533_12465 ENOG4105C34 Pseudouridine synthase I533_12470 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane I533_12480 ENOG4105K6V RNA polymerase I533_12495 ENOG4105EMU Dehydrogenase I533_12510 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase I533_12515 ENOG4106VK6 Flagellar motor protein I533_12520 ENOG4105E14 MotA TolQ exbB proton channel I533_12530 ENOG4105CTB Polyprenyl synthetase I533_12535 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) I533_12540 ENOG4108ZAI phosphatidylglycerophosphatase a I533_12545 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) I533_12550 ENOG4107YIM Involved in the transcription termination process (By similarity) I533_12555 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) I533_12570 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) I533_12575 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) I533_12580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) I533_12585 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I533_12590 ENOG4105C5H ABC transporter I533_12600 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) I533_12610 ENOG4105EAC phosphoserine phosphatase I533_12620 ENOG4105EYA deoxyribonuclease I533_12625 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) I533_12635 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) I533_12640 ENOG4105C3F Signal peptidase i I533_12645 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) I533_12665 ENOG4105EMN RNA polymerase sigma factor I533_12670 ENOG4108IYU L-aspartate oxidase I533_12685 ENOG4105Y75 tpr repeat protein I533_12690 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) I533_12695 ENOG4108YZY peptidylprolyl cis-trans isomerase I533_12700 ENOG4108YZA Nitrogen regulatory protein pii I533_12705 ENOG4107RA1 nh(3)-dependent nad( ) synthetase I533_12765 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) I533_12770 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase I533_12775 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) I533_12780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) I533_12785 ENOG4105DTN riboflavin biosynthesis protein ribF I533_12790 ENOG4105CJR Integral membrane protein (MviN I533_12795 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) I533_12810 ENOG4105EWI Short-chain dehydrogenase reductase Sdr I533_12815 ENOG4105C09 Bile acid I533_12820 ENOG4105DQS Transcriptional regulator I533_12835 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) I533_12840 ENOG4105EIN peptidylprolyl cis-trans isomerase I533_12845 ENOG4105K70 DNA-binding protein I533_12855 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) I533_12860 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) I533_12865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) I533_12870 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation I533_12875 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) I533_12885 ENOG4108R96 Methyltransferase, YaeB family I533_12890 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) I533_12895 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) I533_12900 ENOG4105HDD phospholipase I533_12905 ENOG4105DGU Histone deacetylase I533_12910 ENOG4108NVR Methyl-accepting chemotaxis I533_12915 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) I533_12920 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) I533_12925 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) I533_12940 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) I533_12945 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I533_12950 ENOG4105N21 Membrane I533_12955 ENOG4105CUT histidyl-tRNA synthetase I533_12960 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) I533_12975 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs I533_12980 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) I533_12985 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) I533_12995 ENOG4108Z4V iron-sulfur cluster assembly I533_13000 ENOG4105C9B Cysteine desulfurase I533_13005 ENOG4105JRK feS assembly protein SufD I533_13010 ENOG4105C3K feS assembly ATPase SufC I533_13020 ENOG4105C3J Cysteine desulfurase I533_13030 ENOG4105CT3 Monooxygenase I533_13035 ENOG4105D7W serine acetyltransferase I533_13040 ENOG4105CVS RNA methyltransferase TrmH family, group 1 I533_13060 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) I533_13065 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) I533_13070 ENOG4105VIE preprotein translocase, subunit YajC I533_13075 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) I533_13080 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) I533_13095 ENOG4108P9J Phage shock protein A I533_13120 ENOG4106032 Glutathionylspermidine synthase I533_13135 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) I533_13150 ENOG4105CSV Glutaminase I533_13155 ENOG4105G6Z alkaline phosphatase I533_13165 ENOG4107RET Isocitrate lyase I533_13195 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) I533_13240 ENOG4105D06 uba thif-type nad fad binding protein I533_13300 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) I533_13325 ENOG4105BZF Glycosyl transferase (Group 1 I533_13350 ENOG4105CAQ asparagine synthetase I533_13355 ENOG4105CPK Glycosyl transferase (Group 1 I533_13390 ENOG4108QV3 biosynthesis protein I533_13405 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) I533_13410 ENOG41082IR Excinuclease ABC C subunit domain protein I533_13425 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) I533_13435 ENOG4105D1S lipid A biosynthesis I533_13465 ENOG4107QPN acyl-Coa dehydrogenase I533_13480 ENOG4105BZU Histidine kinase I533_13485 ENOG4107104 thymidine kinase I533_13500 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) I533_13525 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) I533_13530 ENOG4108RWN rrna methyltransferase I533_13535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I533_13550 ENOG4105C26 Dehydrogenase I533_13555 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) I533_13570 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) I533_13595 ENOG4105CSU acyl-Coa dehydrogenase I533_13625 ENOG4105E3W Two component transcriptional regulator (Winged helix family I533_13630 ENOG4105E0F Histidine kinase I533_13640 ENOG4105NA0 Transcriptional regulator I533_13645 ENOG410822N TonB family I533_13660 ENOG4107XDR Lactoylglutathione lyase I533_13670 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit I533_13675 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding I533_13680 ENOG4105C7W Xanthine dehydrogenase I533_13700 ENOG4105CHR reductase I533_13710 ENOG4105EMU Dehydrogenase I533_13715 ENOG4107RKG DJ-1/PfpI family I533_13720 ENOG4107U9T Pfam:Ribonuclease_BN I533_13730 ENOG4108VWS Yaeq family I533_13760 ENOG4105S8Q sugar efflux transporter I533_13775 ENOG4105C9U ATP-dependent DNA helicase RecQ I533_13795 ENOG4105BZU Histidine kinase I533_13805 ENOG4105BZU Histidine kinase I533_13810 ENOG4105D8V Glucose sorbosone dehydrogenase I533_13825 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) I533_13830 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) I533_13835 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) I533_13840 ENOG4105CQM Urea amidohydrolase subunit alpha I533_13845 ENOG4105KI2 Urea amidohydrolase subunit beta I533_13850 ENOG4108YZ9 Urea amidohydrolase subunit gamma I533_13855 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) I533_13860 ENOG4108IV0 ABC, transporter I533_13865 ENOG4105C0Z ABC transporter I533_13875 ENOG4105C32 Amino acid ABC transporter (Permease) I533_13890 ENOG4105BZU Histidine kinase I533_13895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I533_13920 ENOG4105E7D Protein of unknown function (DUF3375) I533_13930 ENOG4105CVR type I restriction-modification system I533_13945 ENOG4105DZR Type I site-specific deoxyribonuclease I533_13955 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor I533_13960 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) I533_13965 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) I533_13970 ENOG4105CE4 GlcNAc 6-P deacetylase I533_13975 ENOG4105RD7 BadF BadG BcrA BcrD I533_13985 ENOG4105DAA L-lactate I533_14010 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family I533_14015 ENOG4105D0A hydroxylase I533_14020 ENOG4107RAQ aminopeptidase I533_14030 ENOG4108RVA ribokinase I533_14045 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase I533_14050 ENOG4105E66 phosphoriboisomerase A I533_14055 ENOG4108JQ1 Dehydrogenase I533_14075 ENOG4105XZD Fe-S protein I533_14105 ENOG4107QN2 dihydrolipoyl dehydrogenase I533_14110 ENOG4107QSN dihydrolipoamide acetyltransferase I533_14115 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) I533_14120 ENOG41073TP transcriptional regulator I533_14130 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase I533_14135 ENOG4108WIW Aspartyl protease I533_14140 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase I533_14150 ENOG4105D7Q type ii secretion system I533_14165 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) I533_14170 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) I533_14175 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) I533_14180 ENOG4105M6F mutator MutT protein I533_14185 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving I533_14190 ENOG4105DR5 peptidase I533_14195 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I533_14200 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) I533_14205 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) I533_14210 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) I533_14215 ENOG4105CPF Cell wall formation (By similarity) I533_14220 ENOG4105DFU Cell wall formation (By similarity) I533_14225 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) I533_14230 ENOG4105CNI cell division protein FtsW I533_14235 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) I533_14240 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) I533_14245 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) I533_14250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) I533_14255 ENOG4105CJN penicillin-binding protein I533_14260 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) I533_14265 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) I533_14270 ENOG4108V6E Cell division protein mraZ I533_14290 ENOG4108IJF Heavy metal efflux pump, CzcA I533_14315 ENOG4105EHV domain protein I533_14330 ENOG4105BZU Histidine kinase I533_14340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_14345 ENOG4105BZU Histidine kinase I533_14380 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) I533_14385 ENOG4105D7Z glutathione synthase I533_14390 ENOG4108UJU UPF0301 protein I533_14395 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) I533_14405 ENOG4105CZX twitching motility protein I533_14410 ENOG4105CZX twitching motility protein I533_14415 ENOG4105DFA alanine racemase domain protein I533_14420 ENOG4105II7 pyrroline-5-carboxylate reductase I533_14425 ENOG4108VIA integral membrane protein I533_14435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I533_14450 ENOG4108SHQ Glutathione S-transferase I533_14455 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I533_14460 ENOG4108Z9K Osmotically inducible protein I533_14465 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) I533_14480 ENOG4108UMN azlc family I533_14490 ENOG4105F27 Major Facilitator I533_14495 ENOG4105VFU Rna-binding protein I533_14500 ENOG4105D1Q UPF0246 protein I533_14510 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) I533_14515 ENOG4107QP8 phosphohexose isomerase I533_14525 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) I533_14530 ENOG4105D98 threonine synthase I533_14535 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) I533_14550 ENOG4105CC0 LysR family Transcriptional regulator I533_14565 ENOG41082YX Transcriptional regulator, arsr family I533_14575 ENOG4105CAU Arsenical resistance protein, ArsH I533_14580 ENOG4105D6J arsenicaL-resistance protein I533_14585 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) I533_14590 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) I533_14625 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) I533_14650 ENOG4105E3Q saccharopine dehydrogenase I533_14665 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) I533_14670 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) I533_14675 ENOG41082RQ UPF0102 protein I533_14680 ENOG4105CPK Glycosyl transferase (Group 1 I533_14685 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) I533_14690 ENOG4105W4M Transport-associated protein I533_14710 ENOG4105BZU Histidine kinase I533_14740 ENOG4105CR4 methylisocitrate lyase I533_14745 ENOG4105BZN citrate synthase I533_14750 ENOG4108I0Z Aconitate hydratase I533_14755 ENOG4105C7F AcnD-accessory protein PrpF I533_14760 ENOG4105BZU Histidine kinase I533_14780 ENOG4105BZU Histidine kinase I533_14785 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase I533_14790 ENOG4105CBC glutamate synthase I533_14795 ENOG4105BZ8 glutamate synthase I533_14810 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I533_14815 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) I533_14820 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) I533_14825 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) I533_14840 ENOG4105CJP fad dependent oxidoreductase I533_14845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) I533_14855 ENOG4108K5P (LipO)protein I533_14860 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) I533_14865 ENOG4105EDR glucose galactose transporter I533_14875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I533_14895 ENOG4108U78 Glutathione S-transferase I533_14900 ENOG4108YX9 iron--sulfur cluster insertion protein erpA I533_14910 ENOG4105CSR polyphosphate kinase 2 I533_14915 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) I533_14920 ENOG4107QMS site-determining protein I533_14925 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) I533_14930 ENOG4105C9Q fumarate hydratase class II I533_14965 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) I533_14970 ENOG4105CHM Aminotransferase I533_14980 ENOG4105CI3 gtp-binding protein typa I533_14990 ENOG4105C5F glutamine synthetase I533_15000 ENOG4105CUX Signal transduction histidine kinase I533_15005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_15010 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I533_15015 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase I533_15020 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) I533_15055 ENOG4105BZU Histidine kinase I533_15060 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) I533_15065 ENOG4105MYG DNA polymerase iii, chi subunit I533_15070 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) I533_15075 ENOG4108M8S permease YjgP YjgQ family protein I533_15080 ENOG4108K5H permease YjgP YjgQ family protein I533_15095 ENOG4105K6V RNA polymerase I533_15160 ENOG4105M03 Domain of unknown function (DUF955) I533_15280 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) I533_15285 ENOG4105EHG Permease protein I533_15290 ENOG4107R4I Periplasmic binding protein I533_15300 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I533_15315 ENOG4105CP7 Triose-phosphate isomerase I533_15320 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 I533_15325 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 I533_15330 ENOG4105C6V Glycerol-3-phosphate dehydrogenase I533_15335 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) I533_15340 ENOG4108IJ9 (ABC) transporter I533_15375 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) I533_15380 ENOG4105EMK carboxylate amino acid amine transporter I533_15405 ENOG4107RF2 cellulose-binding family II protein I533_15415 ENOG4105CY0 Metallo-Beta-Lactamase I533_15430 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) I533_15435 ENOG4105BZU Histidine kinase I533_15440 ENOG4108N2Y auxin Efflux I533_15455 ENOG4105DZG Dehydrogenase I533_15475 ENOG4105CJ1 ABC, transporter I533_15485 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) I533_15490 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) I533_15495 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) I533_15505 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E I533_15535 ENOG4105BZU Histidine kinase I533_15555 ENOG4105WH1 Two component transcriptional regulator luxr family I533_15560 ENOG4105BZU Histidine kinase I533_15565 ENOG4105JQN Transcriptional regulator I533_15570 ENOG4105C26 Dehydrogenase I533_15575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase I533_15580 ENOG4105C94 Transporter I533_15585 ENOG4105CXG d-lactate dehydrogenase I533_15590 ENOG41086KC Transcriptional regulator I533_15595 ENOG4105P8Q Curli production assembly transport component CsgG I533_15625 ENOG4105WH1 Two component transcriptional regulator luxr family I533_15640 ENOG4105C1J atp-dependent rna helicase I533_15645 ENOG4105BZU Histidine kinase I533_15660 ENOG4108UHU Aldolase I533_15665 ENOG4107SS6 2-dehydro-3-deoxygluconokinase I533_15680 ENOG4105EGS Mechanosensitive ion channel I533_15690 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) I533_15720 ENOG4105HF0 Membrane I533_15725 ENOG4105CIH Imidazole acetol-phosphate transaminase I533_15740 ENOG4105BZU Histidine kinase I533_15750 ENOG4105CQ2 DNA polymerase I533_15760 ENOG4105CEY Amp-dependent synthetase and ligase I533_15775 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) I533_15780 ENOG4105EJ2 Transcriptional regulator I533_15790 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) I533_15800 ENOG4108RG0 uracil-dna glycosylase I533_15805 ENOG4105BZU Histidine kinase I533_15815 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) I533_15820 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) I533_15845 ENOG4105FM1 phage shock protein C I533_15850 ENOG41087YS Phage shock protein A I533_15860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) I533_15880 ENOG4105UYK outer membrane protein a I533_15885 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) I533_15890 ENOG4105BZU Histidine kinase I533_15895 ENOG4105C4W S-formylglutathione hydrolase I533_15900 ENOG4106HNH Acyl-transferase I533_15905 ENOG4106HNH Acyl-transferase I533_15910 ENOG4105CUY Mechanosensitive ion channel I533_15925 ENOG4108535 NAD dependent epimerase/dehydratase family I533_15930 ENOG4105C8J )-transporter I533_15945 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) I533_15960 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) I533_15970 ENOG4109015 Biopolymer transport protein exbD tolR I533_15990 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) I533_16005 ENOG4107QZ7 Cellulose synthase catalytic subunit I533_16020 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) I533_16025 ENOG4105K4T epimerase I533_16035 ENOG4105KWG Pfam:DUF1696 I533_16040 ENOG4105BZU Histidine kinase I533_16055 ENOG4105EFZ amidohydrolase I533_16065 ENOG4105C5X domain protein I533_16075 ENOG4108WAV Transcriptional regulator I533_16080 ENOG4105E7A Glutamine amidotransferase I533_16085 ENOG4108Z12 YiaAB two helix domain-containing protein I533_16105 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease I533_16115 ENOG4105C26 Dehydrogenase I533_16120 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) I533_16125 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) I533_16130 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) I533_16140 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) I533_16145 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) I533_16150 ENOG4108R86 Transcriptional regulator I533_16165 ENOG4105VYA Uncharacterized conserved protein (DUF2132) I533_16180 ENOG4105C6Z Gluconate I533_16190 ENOG4105K2J Transcriptional regulator I533_16195 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) I533_16205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I533_16215 ENOG4105CJ2 (LipO)protein I533_16220 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) I533_16225 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I533_16230 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I533_16235 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I533_16240 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I533_16245 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I533_16250 ENOG4105RKW reductase (By I533_16255 ENOG4108V1T peptidylprolyl cis-trans isomerase I533_16260 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) I533_16270 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) I533_16280 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) I533_16285 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) I533_16295 ENOG4108KPZ tonB-dependent Receptor I533_16310 ENOG4105DBI uridine monophosphokinase I533_16315 ENOG4105D9N nucleoside I533_16335 ENOG4105BZU Histidine kinase I533_16340 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) I533_16350 ENOG4107QN1 sodium solute I533_16370 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I533_16380 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I533_16395 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) I533_16410 ENOG4105CPC Aldo Keto reductase I533_16430 ENOG4105BZU Histidine kinase I533_16440 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I533_16445 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) I533_16450 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase I533_16455 ENOG4105D4A Cell wall formation (By similarity) I533_16460 ENOG4108N3W hemolysin secretion protein I533_16480 ENOG4108JJA ABC, transporter I533_16485 ENOG41063Z6 transcriptional regulator, lysR family I533_16505 ENOG4105C1B dTDP-glucose 4-6-dehydratase I533_16510 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase I533_16515 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase I533_16520 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) I533_16540 ENOG4105FGF GDP-mannose mannosyl hydrolase I533_16545 ENOG4105C30 Nad-dependent epimerase dehydratase I533_16575 ENOG4105C0K Gdp-mannose 4,6-dehydratase I533_16590 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) I533_16645 ENOG4105EQK -acetyltransferase I533_16700 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) I533_16740 ENOG4105CJT Mannose-1-phosphate guanylyltransferase I533_16760 ENOG41084HI prevent-host-death family I533_16765 ENOG4108ZT0 50S ribosomal protein l17 I533_16770 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I533_16775 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) I533_16780 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) I533_16785 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits I533_16790 ENOG41067V7 50S ribosomal protein L36 I533_16795 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) I533_16800 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) I533_16805 ENOG4105VPB 50S ribosomal protein L30 I533_16810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) I533_16815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) I533_16820 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) I533_16825 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) I533_16830 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) I533_16835 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits I533_16840 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) I533_16845 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) I533_16850 ENOG4105BZU Histidine kinase I533_16860 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I533_16870 ENOG4105C2N RNA methyltransferase TrmH family group 3 I533_16875 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) I533_16920 ENOG4108UV7 flagellar protein motX I533_16930 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) I533_16935 ENOG4107QK7 reductase I533_16950 ENOG4107VAM peptidase, m28 I533_16960 ENOG4105BZU Histidine kinase I533_16970 ENOG4105C4M (Ubiquinol oxidase) subunit I I533_16975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I533_16985 ENOG4108XM1 transcriptional regulator AsnC family I533_16995 ENOG4105VEQ Cold shock protein I533_17000 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) I533_17020 ENOG4105DGW oligopeptidase A I533_17025 ENOG4107YTP response regulator receiver protein I533_17035 ENOG4105BZU Histidine kinase I533_17040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_17045 ENOG4105DC8 reductase I533_17050 ENOG4107QY8 reductase I533_17055 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I533_17105 ENOG4105C42 Type I secretion membrane fusion protein (HlyD I533_17110 ENOG4108JJA ABC, transporter I533_17115 ENOG4105WH1 Two component transcriptional regulator luxr family I533_17125 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I533_17135 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression I533_17140 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) I533_17145 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) I533_17150 ENOG41063M6 Cell Division Protein I533_17155 ENOG4105C25 Primosomal protein n' I533_17160 ENOG4105VFB Binds the 23S rRNA (By similarity) I533_17170 ENOG4105C6K Malic enzyme I533_17175 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) I533_17180 ENOG4105SYT Methylenetetrahydrofolate reductase I533_17185 ENOG4107S2Z UPF0761 membrane protein I533_17205 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) I533_17210 ENOG4105SUU thioesterase domain I533_17215 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I533_17220 ENOG4105D58 Diguanylate phosphodiesterase I533_17225 ENOG4105D58 Diguanylate phosphodiesterase I533_17230 ENOG4105CRP Part of the ABC transporter FtsEX involved in I533_17235 ENOG4105CAK Cell division ATP-binding protein ftsE I533_17240 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) I533_17245 ENOG4106H78 methyltransferase I533_17255 ENOG41076UM multiple antibiotic resistance (MarC)-related protein I533_17270 ENOG4105PW4 Sugar fermentation stimulation protein homolog I533_17275 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters I533_17280 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) I533_17285 ENOG4105DJ0 Poly(A) Polymerase I533_17290 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase I533_17295 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) I533_17300 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) I533_17305 ENOG4105DY8 decarboxylase I533_17320 ENOG4105E3A (ABC) transporter I533_17325 ENOG4105DA5 (ABC) transporter I533_17330 ENOG4105E3W Two component transcriptional regulator (Winged helix family I533_17335 ENOG4105EB3 Histidine kinase I533_17340 ENOG4108ESX Receptor I533_17345 ENOG4107E2E PKHD-type hydroxylase I533_17370 ENOG4105D22 carbon starvation protein I533_17390 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I533_17395 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) I533_17400 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) I533_17405 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) I533_17410 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I533_17415 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I533_17420 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) I533_17425 ENOG4108VZM 50s ribosomal protein L10 I533_17430 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) I533_17435 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) I533_17455 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) I533_17460 ENOG4105PM1 preprotein translocase subunit SecE I533_17465 ENOG4105BZ1 (ABC) transporter I533_17470 ENOG4105JSC dimethylmenaquinone methyltransferase I533_17475 ENOG4105C9K Endothelin-converting enzyme 1 I533_17485 ENOG4105C1J atp-dependent rna helicase I533_17490 ENOG4105EKE dihydroorotase I533_17495 ENOG4105QNF Outer membrane lipoprotein I533_17500 ENOG4107RGM aldo keto reductase I533_17505 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase I533_17515 ENOG4105DP8 Major facilitator superfamily MFS_1 I533_17520 ENOG4107QW3 Sucrose phosphorylase I533_17530 ENOG4105EUJ GTP cyclohydrolase i I533_17535 ENOG410642E Short chain dehydrogenase I533_17540 ENOG4105DWY Agmatine deiminase I533_17555 ENOG4107QRT dEAD DEAH box helicase I533_17565 ENOG4107T0X DNA ligase I533_17570 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) I533_17575 ENOG4105D7K pfkb domain protein I533_17590 ENOG4105CYM Glutathione S-transferase I533_17605 ENOG4107IFA Lipase (EC 3.1.1.3) I533_17610 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I533_17635 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) I533_17640 ENOG4105CFC Transporter I533_17645 ENOG4105EPW hflc protein I533_17650 ENOG4107QJR hflk protein I533_17655 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) I533_17660 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) I533_17665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) I533_17670 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) I533_17675 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I533_17680 ENOG4105K8N protein family UPF0079, ATPase I533_17685 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) I533_17690 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) I533_17700 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) I533_17710 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor I533_17715 ENOG4105MYN Zinc uptake regulation protein I533_17725 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme I533_17730 ENOG4105CDV Ompa motb domain protein I533_17735 ENOG4105CDU Replicative dna helicase I533_17760 ENOG4108RPX mosc domain containing protein I533_17775 ENOG4105K9Q Binds to the 23S rRNA (By similarity) I533_17780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) I533_17785 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) I533_17790 ENOG4105BZU Histidine kinase I533_17800 ENOG4105C19 ABC transporter I533_17810 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor I533_17815 ENOG4105BZU Histidine kinase I533_17820 ENOG4105C8Q Methyl-accepting chemotaxis I533_17830 ENOG4105PGM cation diffusion facilitator family transporter I533_17845 ENOG4105DFD Na H antiporter I533_17865 ENOG41060NJ transcriptional regulator I533_17875 ENOG4108JJ8 (ABC) transporter I533_17880 ENOG4108JJ9 ABC, transporter I533_17890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I533_17895 ENOG4105C4M (Ubiquinol oxidase) subunit I I533_17905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I533_17930 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein I533_17950 ENOG4105Q26 Siderophore-interacting protein I533_17955 ENOG4105VDW Csbd family I533_17985 ENOG4108YZN class I peptide chain release factor I533_17990 ENOG4107TTQ Alpha beta hydrolase fold I533_18010 ENOG4105DS1 cytochrome b561 I533_18020 ENOG4105CEP NADH dehydrogenase I533_18035 ENOG4105CR8 Transcriptional regulator I533_18040 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation I533_18045 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein I533_18055 ENOG4105BZU Histidine kinase I533_18065 ENOG4105DEN Luciferase family I533_18125 ENOG4108M4U conserved membrane protein I533_18155 ENOG4105PGM cation diffusion facilitator family transporter I533_18170 ENOG4105W1Y Transcriptional regulator I533_18200 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) I533_18205 ENOG4105E98 transcriptional regulator DeoR family I533_18210 ENOG4105D9R oxidoreductase I533_18215 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) I533_18225 ENOG4108Q5Y Membrane I533_18230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) I533_18235 ENOG4105D03 DNA-3-methyladenine glycosylase II I533_18240 ENOG41066YJ Beta-lactamase I533_18245 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) I533_18255 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) I533_18260 ENOG4105W8H transhydrogenase (subunit alpha I533_18265 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) I533_18310 ENOG4105KQ5 peptidylprolyl cis-trans isomerase I533_18320 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I533_18325 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) I533_18330 ENOG4105CCU oxidase (Subunit III) I533_18335 ENOG4105BZ9 Cytochrome C oxidase, subunit I I533_18340 ENOG4105E2S oxidase) subunit II I533_18375 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) I533_18380 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) I533_18385 ENOG4105FS0 cytoplasmic membrane protein I533_18390 ENOG4105VF7 tolerance protein I533_18395 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) I533_18400 ENOG4105DR5 peptidase I533_18405 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) I533_18410 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein I533_18415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase I533_18460 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) I533_18470 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) I533_18475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) I533_18480 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) I533_18485 ENOG4105DC1 bifunctional purine biosynthesis protein purh I533_18495 ENOG4105C12 Phosphoribosylglycinamide synthetase I533_18510 ENOG4105EYW Ion transport protein I533_18515 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) I533_18525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family I533_18535 ENOG4105E0F Histidine kinase I533_18545 ENOG4105CJQ hydrolase, family 31 I533_18550 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase I533_18555 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) I533_18560 ENOG4105VEJ Heat shock protein I533_18565 ENOG4108XKW General secretion pathway protein C I533_18575 ENOG4107QHF type ii secretion system protein e I533_18580 ENOG4105D7Q type ii secretion system I533_18585 ENOG4108VAU general secretion pathway protein G I533_18590 ENOG4105VWV general secretion pathway protein h I533_18630 ENOG4105C26 Dehydrogenase I533_18640 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 I533_18645 ENOG4107RK2 ADP-ribose diphosphatase NudE I533_18660 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) I533_18665 ENOG4105DJ9 glucan biosynthesis protein I533_18675 ENOG4105YP7 UPF0270 protein I533_18680 ENOG4105DNZ Alpha Beta Hydrolase I533_18690 ENOG4105C5H ABC transporter I533_18710 ENOG41069P5 Protein slyX homolog I533_18720 ENOG4108V1T peptidylprolyl cis-trans isomerase I533_18730 ENOG4108RRZ Transcription elongation factor GreB I533_18735 ENOG4105BZM domain protein I533_18755 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) I533_18760 ENOG4105MJ2 Competence protein I533_18770 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) I533_18790 ENOG4107R73 Mate efflux family protein I533_18795 ENOG4107BJW polysaccharide deacetylase I533_18805 ENOG4108ZX6 Electron transport protein SCO1 SenC I533_18810 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I533_18815 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) I533_18835 ENOG4107QS1 Cytochrome C Oxidase, Subunit III I533_18840 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) I533_18845 ENOG4105BZ9 Cytochrome C oxidase, subunit I I533_18855 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) I533_18860 ENOG4105E55 glycerol-3-phosphate acyltransferase I533_18865 ENOG4105C7B Threonine dehydratase I533_18870 ENOG4105C01 Dihydroxy-acid dehydratase I533_18875 ENOG4105EN6 Membrane I533_18880 ENOG4105C0P Mg chelatase subunit ChlI I533_18885 ENOG4105EMY transcriptional regulator I533_18890 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase I533_18895 ENOG4105C2C drug resistance transporter, Bcr CflA I533_18905 ENOG4105CFU surface antigen I533_18910 ENOG4105MA0 exported protein I533_18935 ENOG4105C5I Dehydrogenase I533_18945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) I533_18990 ENOG4105CI2 imidazolone-5-propionate hydrolase I533_19015 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) I533_19020 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) I533_19025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) I533_19035 ENOG4105DSJ YicC domain protein I533_19075 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) I533_19100 ENOG4105ENH Sulfatase I533_19105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I533_19120 ENOG4107QVM von Willebrand factor, type A I533_19145 ENOG4107RGH Aldehyde dehydrogenase I533_19155 ENOG410846T CoA-transferase family III I533_19165 ENOG4105C1G acyl-Coa dehydrogenase I533_19175 ENOG4105E39 Enoyl-CoA hydratase I533_19180 ENOG4108ZX5 transcriptional regulator I533_19200 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) I533_19205 ENOG4105CHC glucokinase (EC 2.7.1.2) I533_19210 ENOG4105C01 Dihydroxy-acid dehydratase I533_19215 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I533_19220 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I533_19225 ENOG4106KNT transcriptional regulator I533_19230 ENOG4105CA9 Pyruvate kinase I533_19235 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I533_19270 ENOG4107R3N Filamentation induced by cAMP protein fic I533_19285 ENOG4105QTB Flavodoxin I533_19295 ENOG4108VPT UPF0234 protein I533_19300 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins I533_19305 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) I533_19310 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) I533_19315 ENOG4105VG0 50S ribosomal protein l34