locus-tag	class	description
I533_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I533_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I533_00020	COG0187	DNA topoisomerase II activity
I533_00040	COG2818	Glycosylase
I533_00050	COG3078	GTPase activator activity
I533_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I533_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I533_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I533_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I533_00085	COG0569	domain protein
I533_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I533_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I533_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I533_00110	COG0758	DNA mediated transformation
I533_00125	COG0009	L-threonylcarbamoyladenylate synthase
I533_00130	COG0408	coproporphyrinogen oxidase activity
I533_00135	COG3047	cAMP biosynthetic process
I533_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I533_00160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I533_00205	COG2234	aminopeptidase activity
I533_00210	COG0463	Glycosyl transferase, family 2
I533_00220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I533_00245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_00275	COG3642	lipopolysaccharide core region biosynthetic process
I533_00280	COG0859	PFAM glycosyl transferase family 9
I533_00310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_00325	COG3161	chorismate lyase activity
I533_00330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I533_00350	COG0210	DNA helicase
I533_00395	COG1959	2 iron, 2 sulfur cluster binding
I533_00400	COG0730	response to heat
I533_00415	COG4771	TonB-dependent receptor
I533_00430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I533_00435	COG4988	ABC transporter
I533_00445	COG1271	oxidase subunit
I533_00455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_00455	COG0425	Belongs to the sulfur carrier protein TusA family
I533_00465	COG0450	alkyl hydroperoxide reductase
I533_00475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I533_00505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_00525	COG0582	viral genome integration into host DNA
I533_00555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_00560	COG0842	Transport permease protein
I533_00560	COG1129	ABC transporter
I533_00565	COG0842	Transport permease protein
I533_00575	COG4771	TonB-dependent receptor
I533_00585	COG1960	acyl-CoA dehydrogenase activity
I533_00590	COG0583	DNA-binding transcription factor activity
I533_00600	COG3106	COG3106 Predicted ATPase
I533_00620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I533_00635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I533_00640	COG0352	thiamine-phosphate diphosphorylase activity
I533_00650	COG3071	HemY protein
I533_00655	COG2959	enzyme of heme biosynthesis
I533_00665	COG0181	hydroxymethylbilane synthase activity
I533_00685	COG0194	GDP metabolic process
I533_00695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I533_00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I533_00710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I533_00720	COG0678	peroxiredoxin activity
I533_00735	COG1178	ABC-type Fe3 transport system permease component
I533_00740	COG3842	ATPase activity
I533_00745	COG0668	transmembrane transport
I533_00750	COG2081	HI0933 family
I533_00765	COG2963	transposase activity
I533_00780	COG2200	EAL domain
I533_00785	COG0583	DNA-binding transcription factor activity
I533_00795	COG2076	Multidrug Resistance protein
I533_00810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_00825	COG0427	acetyl-CoA hydrolase
I533_00830	COG0123	including yeast histone deacetylase and acetoin utilization protein
I533_00845	COG0840	transmembrane signaling receptor activity
I533_00855	COG3064	Membrane
I533_00865	COG5002	protein histidine kinase activity
I533_00865	COG5001	Diguanylate cyclase
I533_00880	COG0514	ATP-dependent DNA helicase (RecQ)
I533_00885	COG2239	Acts as a magnesium transporter
I533_00890	COG2962	Rard protein
I533_00895	COG3706	GGDEF domain
I533_00895	COG0745	RESPONSE REGULATOR receiver
I533_00900	COG0210	DNA helicase
I533_00910	COG1011	Hydrolase
I533_00925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I533_00930	COG0019	diaminopimelate decarboxylase activity
I533_00960	COG0163	prenyltransferase activity
I533_00965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I533_00975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I533_00995	COG1077	Cell shape determining protein MreB Mrl
I533_01005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I533_01010	COG2814	Major facilitator Superfamily
I533_01015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_01045	COG1085	galactose-1-phosphate uridylyltransferase
I533_01050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I533_01060	COG0629	single-stranded DNA binding
I533_01075	COG3250	beta-galactosidase activity
I533_01095	COG1349	DNA-binding transcription factor activity
I533_01140	COG3409	Peptidoglycan-binding domain 1 protein
I533_01140	COG3267	Type II secretory pathway component ExeA
I533_01150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I533_01155	COG1459	type II secretion system
I533_01200	COG1077	Cell shape determining protein MreB Mrl
I533_01205	COG1792	Involved in formation and maintenance of cell shape
I533_01210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I533_01220	COG1530	ribonuclease E activity
I533_01230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_01235	COG0312	modulator of DNA gyrase
I533_01240	COG3028	Belongs to the UPF0307 family
I533_01245	COG0312	modulator of DNA gyrase
I533_01260	COG0745	RESPONSE REGULATOR receiver
I533_01265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_01265	COG4191	Histidine kinase
I533_01270	COG0297	glycogen (starch) synthase activity
I533_01280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I533_01285	COG0596	Alpha beta hydrolase
I533_01310	COG1204	response to ionizing radiation
I533_01320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I533_01325	COG5002	protein histidine kinase activity
I533_01330	COG0745	RESPONSE REGULATOR receiver
I533_01350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_01450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I533_01480	COG0375	protein maturation
I533_01490	COG0409	Hydrogenase expression formation protein
I533_01500	COG0309	Hydrogenase expression formation protein (HypE)
I533_01505	COG0789	Transcriptional regulator
I533_01510	COG2217	Heavy metal translocating P-type atpase
I533_01600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I533_01610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I533_01620	COG0463	Glycosyl transferase, family 2
I533_01625	COG0745	RESPONSE REGULATOR receiver
I533_01695	COG2801	Transposase and inactivated derivatives
I533_01700	COG0789	Transcriptional regulator
I533_01705	COG2217	Heavy metal translocating P-type atpase
I533_01745	COG0531	amino acid
I533_01755	COG2132	Multicopper oxidase
I533_01770	COG0840	transmembrane signaling receptor activity
I533_01780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I533_01830	COG0546	phosphoglycolate phosphatase activity
I533_01855	COG1609	Transcriptional regulator
I533_01860	COG0673	inositol 2-dehydrogenase activity
I533_01870	COG2211	Major facilitator Superfamily
I533_01895	COG1454	alcohol dehydrogenase
I533_01945	COG0089	rRNA binding
I533_01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I533_01965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I533_01980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I533_01985	COG0438	transferase activity, transferring glycosyl groups
I533_01995	COG1519	Transferase
I533_02015	COG0840	transmembrane signaling receptor activity
I533_02030	COG0788	formyltetrahydrofolate deformylase activity
I533_02040	COG1643	Atp-dependent helicase
I533_02045	COG2951	lytic endotransglycosylase activity
I533_02050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I533_02065	COG2354	Protein conserved in bacteria
I533_02070	COG4977	sequence-specific DNA binding
I533_02085	COG0004	ammonium transporteR
I533_02090	COG0405	Gamma-glutamyltransferase
I533_02095	COG2837	iron assimilation
I533_02110	COG0540	Belongs to the ATCase OTCase family
I533_02135	COG2205	protein histidine kinase activity
I533_02135	COG5002	protein histidine kinase activity
I533_02135	COG0784	Response regulator, receiver
I533_02150	COG5001	Diguanylate cyclase
I533_02150	COG3300	MHYT domain
I533_02160	COG1012	belongs to the aldehyde dehydrogenase family
I533_02170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I533_02185	COG0180	Tryptophanyl-tRNA synthetase
I533_02190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I533_02210	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I533_02220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I533_02255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I533_02260	COG0281	malic enzyme
I533_02270	COG0625	glutathione transferase activity
I533_02280	COG0753	catalase activity
I533_02305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I533_02305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I533_02315	COG0137	argininosuccinate synthase activity
I533_02335	COG1803	Methylglyoxal synthase
I533_02345	COG0745	RESPONSE REGULATOR receiver
I533_02350	COG2205	protein histidine kinase activity
I533_02355	COG2267	carboxylic ester hydrolase activity
I533_02360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I533_02370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I533_02380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I533_02385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_02390	COG4942	peptidase
I533_02395	COG2861	carbohydrate metabolic process
I533_02420	COG1162	GTPase activity
I533_02425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I533_02455	COG0270	DNA (cytosine-5-)-methyltransferase activity
I533_02465	COG0028	Belongs to the TPP enzyme family
I533_02485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I533_02490	COG0805	protein transport
I533_02500	COG0084	hydrolase, TatD family'
I533_02505	COG5001	Diguanylate cyclase
I533_02505	COG4251	negative regulation of phosphorylation
I533_02505	COG3706	GGDEF domain
I533_02505	COG2203	Gaf domain
I533_02515	COG0248	Ppx GppA phosphatase
I533_02520	COG0513	Belongs to the DEAD box helicase family
I533_02525	COG3118	belongs to the thioredoxin family
I533_02530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I533_02540	COG0784	Response regulator, receiver
I533_02540	COG5002	protein histidine kinase activity
I533_02545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I533_02555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I533_02565	COG0783	Belongs to the Dps family
I533_02570	COG2133	pyrroloquinoline quinone binding
I533_02575	COG1506	peptidase
I533_02575	COG0823	Involved in the tonB-independent uptake of proteins
I533_02575	COG4946	Tricorn protease homolog
I533_02585	COG3118	belongs to the thioredoxin family
I533_02600	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I533_02610	COG1012	belongs to the aldehyde dehydrogenase family
I533_02630	COG1757	Na H antiporter
I533_02645	COG3876	Protein conserved in bacteria
I533_02650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I533_02660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I533_02695	COG2824	Alkylphosphonate utilization operon protein PhnA
I533_02700	COG0454	-acetyltransferase
I533_02725	COG3093	addiction module antidote protein HigA
I533_02740	COG2026	Addiction module toxin, RelE StbE family
I533_02765	COG3547	Transposase (IS116 IS110 IS902 family)
I533_02800	COG0183	Belongs to the thiolase family
I533_02805	COG1024	Enoyl-CoA hydratase
I533_02805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_02815	COG0006	proline dipeptidase activity
I533_02825	COG0142	geranyltranstransferase activity
I533_02855	COG1388	LysM domain
I533_02855	COG4942	peptidase
I533_02860	COG1238	metal cluster binding
I533_02870	COG0585	pseudouridine synthase activity
I533_02875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I533_02885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I533_02895	COG0840	transmembrane signaling receptor activity
I533_02905	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I533_02905	COG0506	proline dehydrogenase activity
I533_02905	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I533_02935	COG0494	nUDIX hydrolase
I533_02940	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I533_02945	COG0730	response to heat
I533_02950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I533_02955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I533_02965	COG3706	GGDEF domain
I533_02965	COG0745	RESPONSE REGULATOR receiver
I533_02990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I533_03005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I533_03015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I533_03015	COG1648	precorrin-2 dehydrogenase activity
I533_03020	COG0513	Belongs to the DEAD box helicase family
I533_03040	COG1538	Outer membrane efflux protein
I533_03045	COG0494	nUDIX hydrolase
I533_03055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I533_03060	COG3150	esterase
I533_03065	COG0187	DNA topoisomerase II activity
I533_03075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_03100	COG1509	lysine 2,3-aminomutase activity
I533_03110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I533_03125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I533_03140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I533_03155	COG0271	Belongs to the BolA IbaG family
I533_03170	COG3707	response regulator
I533_03185	COG0659	secondary active sulfate transmembrane transporter activity
I533_03190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I533_03200	COG0243	molybdopterin cofactor binding
I533_03205	COG1648	precorrin-2 dehydrogenase activity
I533_03205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I533_03210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I533_03220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I533_03220	COG1116	anion transmembrane transporter activity
I533_03230	COG1116	anion transmembrane transporter activity
I533_03245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_03250	COG4206	TonB-dependent receptor
I533_03260	COG0348	domain, Protein
I533_03275	COG1960	acyl-CoA dehydrogenase activity
I533_03280	COG1028	Short-chain dehydrogenase reductase Sdr
I533_03290	COG4948	Mandelate Racemase Muconate Lactonizing
I533_03315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_03335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I533_03340	COG0358	DNA primase activity
I533_03345	COG1610	YqeY-like protein
I533_03365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I533_03370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I533_03385	COG0537	adenosine 5'-monophosphoramidase activity
I533_03400	COG3135	benzoate transporter
I533_03405	COG1396	sequence-specific DNA binding
I533_03410	COG2974	May be involved in recombination
I533_03415	COG4191	Histidine kinase
I533_03415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_03420	COG0745	RESPONSE REGULATOR receiver
I533_03425	COG5002	protein histidine kinase activity
I533_03450	COG0811	peptide transport
I533_03455	COG0811	peptide transport
I533_03460	COG0848	biopolymer transport protein
I533_03465	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I533_03475	COG3437	response regulator, receiver
I533_03495	COG0527	aspartate kinase activity
I533_03505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I533_03510	COG2967	ApaG domain
I533_03520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I533_03525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_03530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I533_03535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I533_03545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_03565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I533_03580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I533_03585	COG3956	TIGRFAM MazG family protein
I533_03610	COG1028	Short-chain dehydrogenase reductase Sdr
I533_03620	COG0318	PFAM AMP-dependent synthetase and ligase
I533_03630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I533_03640	COG0463	Glycosyl transferase, family 2
I533_03665	COG0745	RESPONSE REGULATOR receiver
I533_03675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I533_03680	COG0723	plastoquinol--plastocyanin reductase activity
I533_03685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I533_03690	COG2857	Cytochrome c1
I533_03695	COG0625	glutathione transferase activity
I533_03700	COG2969	positive regulation of protein catabolic process
I533_03705	COG2239	Acts as a magnesium transporter
I533_03710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I533_03720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I533_03730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I533_03735	COG1137	ATPase activity
I533_03740	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I533_03750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I533_03765	COG1127	ABC transporter
I533_03770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I533_03775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I533_03780	COG2854	intermembrane phospholipid transfer
I533_03790	COG5007	Belongs to the BolA IbaG family
I533_03800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I533_03805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I533_03815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I533_03860	COG4771	TonB-dependent receptor
I533_03865	COG0697	spore germination
I533_03875	COG2205	protein histidine kinase activity
I533_03875	COG0784	Response regulator, receiver
I533_03900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I533_03910	COG0126	phosphoglycerate kinase activity
I533_03915	COG3588	fructose-bisphosphate aldolase
I533_03925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_03935	COG1538	Outer membrane efflux protein
I533_03940	COG0823	Involved in the tonB-independent uptake of proteins
I533_03940	COG1506	peptidase
I533_03940	COG4946	Tricorn protease homolog
I533_03945	COG0248	Ppx GppA phosphatase
I533_03950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I533_03960	COG0573	inorganic phosphate transmembrane transporter activity
I533_03970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I533_03980	COG0306	phosphate transporter
I533_03990	COG0583	DNA-binding transcription factor activity
I533_04000	COG1272	protein, Hemolysin III
I533_04005	COG1846	Transcriptional regulator
I533_04010	COG1764	response to oxidative stress
I533_04080	COG1739	Uncharacterized protein family UPF0029
I533_04090	COG0420	3'-5' exonuclease activity
I533_04095	COG0419	ATPase involved in DNA repair
I533_04100	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I533_04115	COG2188	Transcriptional regulator
I533_04125	COG2986	histidine ammonia-lyase
I533_04155	COG0668	transmembrane transport
I533_04205	COG1346	cytolysis
I533_04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I533_04240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I533_04245	COG0513	Belongs to the DEAD box helicase family
I533_04260	COG3267	Type II secretory pathway component ExeA
I533_04260	COG3409	Peptidoglycan-binding domain 1 protein
I533_04280	COG0066	3-isopropylmalate dehydratase activity
I533_04290	COG0473	3-isopropylmalate dehydrogenase activity
I533_04295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I533_04315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I533_04330	COG4555	ABC transporter
I533_04335	COG1668	transmembrane transport
I533_04360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_04365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_04370	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I533_04380	COG1138	Cytochrome C-type biogenesis protein
I533_04385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I533_04400	COG2853	Lipoprotein
I533_04405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I533_04415	COG3104	oligopeptide transport
I533_04445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I533_04460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I533_04465	COG1555	photosystem II stabilization
I533_04465	COG1596	polysaccharide export
I533_04470	COG0473	3-isopropylmalate dehydrogenase activity
I533_04485	COG1611	Belongs to the LOG family
I533_04490	COG0745	RESPONSE REGULATOR receiver
I533_04490	COG3706	GGDEF domain
I533_04495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I533_04495	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I533_04550	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I533_04555	COG0024	Methionine aminopeptidase
I533_04560	COG0052	Belongs to the universal ribosomal protein uS2 family
I533_04570	COG0528	UMP kinase activity
I533_04580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I533_04585	COG0575	Belongs to the CDS family
I533_04610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I533_04630	COG0587	DNA-directed DNA polymerase activity
I533_04635	COG0825	malonyl-CoA metabolic process
I533_04640	COG0037	tRNA processing
I533_04660	COG0590	tRNA wobble adenosine to inosine editing
I533_04675	COG0047	phosphoribosylformylglycinamidine synthase activity
I533_04675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I533_04685	COG2840	Smr protein MutS2
I533_04730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_04735	COG2197	response regulator
I533_04775	COG0784	Response regulator, receiver
I533_04775	COG0835	chemotaxis
I533_04780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I533_04785	COG1815	bacterial-type flagellum-dependent cell motility
I533_04790	COG1558	bacterial-type flagellum-dependent cell motility
I533_04795	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I533_04800	COG1749	Flagellar hook protein flgE
I533_04805	COG4787	bacterial-type flagellum-dependent cell motility
I533_04810	COG4786	Flagellar basal body rod
I533_04825	COG3951	Flagellar rod assembly protein muramidase FlgJ
I533_04825	COG1705	Flagellar rod assembly protein muramidase FlgJ
I533_04830	COG1256	bacterial-type flagellum assembly
I533_04850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I533_04855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I533_04870	COG1516	flagellar protein fliS
I533_04890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I533_04905	COG2089	acid synthase
I533_04915	COG1083	cytidylyl-transferase
I533_04920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I533_04925	COG1086	Polysaccharide biosynthesis protein
I533_04930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I533_04940	COG2204	response regulator
I533_04945	COG3852	Histidine kinase
I533_04950	COG2204	response regulator
I533_04955	COG1677	Flagellar hook-basal body complex protein FliE
I533_04960	COG1766	The M ring may be actively involved in energy transduction
I533_04965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I533_05015	COG1987	bacterial-type flagellum assembly
I533_05025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I533_05030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I533_05040	COG0455	bacterial-type flagellum organization
I533_05055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I533_05060	COG0643	Histidine kinase
I533_05060	COG2198	Histidine kinase
I533_05070	COG1192	Involved in chromosome partitioning
I533_05080	COG0835	chemotaxis
I533_05095	COG1410	methionine synthase
I533_05095	COG0646	methionine synthase
I533_05100	COG0646	methionine synthase
I533_05100	COG1410	methionine synthase
I533_05110	COG3123	guanosine phosphorylase activity
I533_05120	COG0583	DNA-binding transcription factor activity
I533_05125	COG0583	DNA-binding transcription factor activity
I533_05135	COG0659	secondary active sulfate transmembrane transporter activity
I533_05150	COG3590	peptidase
I533_05160	COG2137	regulation of response to DNA damage stimulus
I533_05165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I533_05185	COG0511	ligase activity, forming carbon-carbon bonds
I533_05185	COG5016	pyruvate
I533_05190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I533_05195	COG4172	Belongs to the ABC transporter superfamily
I533_05205	COG4171	peptide transport system, permease
I533_05210	COG4168	peptide transport system, permease
I533_05215	COG0747	negative chemotaxis
I533_05220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I533_05235	COG0625	glutathione transferase activity
I533_05240	COG1522	sequence-specific DNA binding
I533_05305	COG0811	peptide transport
I533_05310	COG0811	peptide transport
I533_05315	COG0848	biopolymer transport protein
I533_05330	COG1444	tRNA N-acetyltransferase activity
I533_05365	COG0583	DNA-binding transcription factor activity
I533_05370	COG2814	Major facilitator Superfamily
I533_05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_05380	COG0656	L-ascorbic acid biosynthetic process
I533_05400	COG1846	Transcriptional regulator
I533_05455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I533_05480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I533_05495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I533_05500	COG1401	restriction endodeoxyribonuclease activity
I533_05545	COG4584	PFAM Integrase catalytic
I533_05555	COG1484	DNA-dependent DNA replication
I533_05610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I533_05625	COG0681	Belongs to the peptidase S26 family
I533_05665	COG0629	single-stranded DNA binding
I533_05685	COG0714	Associated with various cellular activities
I533_05710	COG2003	Belongs to the UPF0758 family
I533_05825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_05915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_05925	COG3706	GGDEF domain
I533_05965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I533_05970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I533_05975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I533_05980	COG0564	pseudouridine synthase activity
I533_05990	COG0612	Peptidase, M16
I533_05995	COG2918	glutathione biosynthetic process
I533_06020	COG2840	Smr protein MutS2
I533_06025	COG2890	protein-(glutamine-N5) methyltransferase activity
I533_06040	COG2719	SpoVR family
I533_06045	COG2718	Belongs to the UPF0229 family
I533_06050	COG2766	serine protein kinase
I533_06060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I533_06065	COG4771	TonB-dependent receptor
I533_06090	COG0450	alkyl hydroperoxide reductase
I533_06095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I533_06100	COG2885	chlorophyll binding
I533_06105	COG0584	glycerophosphoryl diester phosphodiesterase
I533_06110	COG0346	lactoylglutathione lyase activity
I533_06115	COG1278	Cold shock
I533_06135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I533_06140	COG4660	Part of a membrane complex involved in electron transport
I533_06145	COG4659	FMN binding
I533_06150	COG4658	electron transport chain
I533_06155	COG4656	Part of a membrane complex involved in electron transport
I533_06160	COG2878	Part of a membrane complex involved in electron transport
I533_06170	COG0534	Mate efflux family protein
I533_06175	COG0556	nucleotide-excision repair
I533_06190	COG0602	queuosine metabolic process
I533_06200	COG0367	asparagine synthase
I533_06225	COG3273	potassium ion transport
I533_06225	COG0471	metal ion transport
I533_06240	COG0529	Catalyzes the synthesis of activated sulfate
I533_06245	COG0175	sulfate reduction
I533_06250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_06255	COG2203	Gaf domain
I533_06255	COG2199	diguanylate cyclase activity
I533_06280	COG2304	oxidoreductase activity
I533_06300	COG0714	Associated with various cellular activities
I533_06310	COG1024	Enoyl-CoA hydratase
I533_06310	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_06330	COG1025	Belongs to the peptidase M16 family
I533_06335	COG2062	phosphohistidine phosphatase, SixA
I533_06345	COG4536	flavin adenine dinucleotide binding
I533_06350	COG4137	Cytochrome C assembly protein
I533_06355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I533_06405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_06410	COG1132	(ABC) transporter
I533_06425	COG0228	four-way junction DNA binding
I533_06430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I533_06435	COG0336	Belongs to the RNA methyltransferase TrmD family
I533_06440	COG0335	large ribosomal subunit rRNA binding
I533_06445	COG2860	membrane
I533_06455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I533_06460	COG0287	Prephenate dehydrogenase
I533_06460	COG1605	Chorismate mutase
I533_06465	COG0077	Prephenate dehydratase
I533_06465	COG1605	Chorismate mutase
I533_06475	COG0023	Translation Initiation Factor
I533_06505	COG2205	protein histidine kinase activity
I533_06515	COG2204	response regulator
I533_06535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I533_06540	COG0494	nUDIX hydrolase
I533_06545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I533_06555	COG2255	four-way junction helicase activity
I533_06560	COG0824	Thioesterase
I533_06565	COG0811	peptide transport
I533_06580	COG0823	Involved in the tonB-independent uptake of proteins
I533_06585	COG2885	chlorophyll binding
I533_06590	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I533_06595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I533_06605	COG4667	esterase of the alpha-beta hydrolase superfamily
I533_06610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I533_06640	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I533_06645	COG3038	cytochrome b561
I533_06665	COG0583	DNA-binding transcription factor activity
I533_06670	COG1451	nucleotide metabolic process
I533_06680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_06690	COG3706	GGDEF domain
I533_06700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I533_06700	COG3008	intermembrane lipid transfer
I533_06705	COG2995	paraquat-inducible protein a
I533_06720	COG0017	Asparaginyl-tRNA synthetase
I533_06735	COG0189	ligase activity
I533_06765	COG0156	8-amino-7-oxononanoate synthase activity
I533_06770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_06780	COG3340	Belongs to the peptidase S51 family
I533_06785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I533_06790	COG4139	cobalamin transport
I533_06795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I533_06800	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I533_06815	COG5265	(ABC) transporter
I533_06820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I533_06830	COG0745	RESPONSE REGULATOR receiver
I533_06835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_06845	COG2755	lipolytic protein G-D-S-L family
I533_06850	COG4181	ATPase activity
I533_06855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I533_06860	COG1090	epimerase
I533_06865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I533_06870	COG0628	permease
I533_06880	COG0745	RESPONSE REGULATOR receiver
I533_06895	COG2350	Protein conserved in bacteria
I533_06900	COG0159	tryptophan synthase activity
I533_06910	COG0135	phosphoribosylanthranilate isomerase activity
I533_06910	COG0134	indole-3-glycerol-phosphate synthase activity
I533_06915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I533_06925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I533_06930	COG0613	PHP domain protein
I533_06935	COG0009	L-threonylcarbamoyladenylate synthase
I533_06940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I533_06945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I533_06955	COG0656	L-ascorbic acid biosynthetic process
I533_06960	COG0110	maltose O-acetyltransferase activity
I533_06970	COG2733	membrane
I533_06975	COG0500	methyltransferase
I533_06980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_06985	COG0497	DNA recombination
I533_06990	COG0783	Belongs to the Dps family
I533_07000	COG1454	alcohol dehydrogenase
I533_07005	COG1028	Short-chain dehydrogenase reductase Sdr
I533_07015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I533_07020	COG2610	gluconate transmembrane transporter activity
I533_07035	COG2205	protein histidine kinase activity
I533_07035	COG2198	Histidine kinase
I533_07035	COG0784	Response regulator, receiver
I533_07040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I533_07050	COG0484	heat shock protein binding
I533_07055	COG3909	cytochrome
I533_07060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I533_07075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I533_07080	COG0505	Belongs to the CarA family
I533_07085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I533_07090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I533_07095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I533_07100	COG0857	belongs to the CobB CobQ family
I533_07100	COG0280	phosphate acetyltransferase
I533_07115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I533_07120	COG4535	Mg2 and Co2 transporter CorC
I533_07130	COG1702	phosphate starvation-inducible protein PhoH
I533_07140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_07185	COG1607	acyl-coa hydrolase
I533_07190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I533_07205	COG1115	amino acid carrier protein
I533_07210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I533_07215	COG0012	GTP binding
I533_07235	COG1064	alcohol dehydrogenase
I533_07250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I533_07255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I533_07260	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I533_07265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I533_07275	COG2890	protein-(glutamine-N5) methyltransferase activity
I533_07280	COG3437	response regulator, receiver
I533_07280	COG0784	Response regulator, receiver
I533_07285	COG3094	Invasion gene expression up-regulator, SirB
I533_07300	COG0583	DNA-binding transcription factor activity
I533_07310	COG2363	Small membrane protein
I533_07325	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I533_07330	COG0515	serine threonine protein kinase
I533_07335	COG2116	formate transmembrane transporter activity
I533_07350	COG0714	Associated with various cellular activities
I533_07355	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I533_07360	COG0033	Phosphoglucomutase
I533_07365	COG0058	SHG alpha-glucan phosphorylase activity
I533_07375	COG2988	succinylglutamate desuccinylase activity
I533_07410	COG1393	Belongs to the ArsC family
I533_07435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I533_07460	COG5001	Diguanylate cyclase
I533_07460	COG3300	MHYT domain
I533_07470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_07485	COG2249	NAD(P)H dehydrogenase (quinone) activity
I533_07505	COG1733	regulation of RNA biosynthetic process
I533_07510	COG5001	Diguanylate cyclase
I533_07510	COG3447	MASE1 domain protein
I533_07510	COG5002	protein histidine kinase activity
I533_07520	COG0402	S-adenosylhomocysteine deaminase activity
I533_07525	COG2351	hydroxyisourate hydrolase activity
I533_07540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_07550	COG1309	transcriptional regulator
I533_07565	COG2252	PERMEase
I533_07570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I533_07585	COG5001	Diguanylate cyclase
I533_07585	COG4251	negative regulation of phosphorylation
I533_07585	COG2203	Gaf domain
I533_07585	COG3706	GGDEF domain
I533_07590	COG2203	Gaf domain
I533_07590	COG4251	negative regulation of phosphorylation
I533_07590	COG3706	GGDEF domain
I533_07590	COG5001	Diguanylate cyclase
I533_07595	COG2205	protein histidine kinase activity
I533_07595	COG0784	Response regulator, receiver
I533_07610	COG2233	PERMEase
I533_07625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I533_07630	COG0730	response to heat
I533_07675	COG1028	Short-chain dehydrogenase reductase Sdr
I533_07690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I533_07720	COG4774	siderophore transport
I533_07725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_07745	COG4464	protein tyrosine phosphatase activity
I533_07770	COG5001	Diguanylate cyclase
I533_07770	COG1716	ATPase activity
I533_07780	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I533_07790	COG0438	transferase activity, transferring glycosyl groups
I533_07805	COG1216	Glycosyl transferase, family 2
I533_07805	COG0463	Glycosyl transferase, family 2
I533_07815	COG2327	Polysaccharide pyruvyl transferase
I533_07825	COG3039	Transposase
I533_07840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I533_07840	COG2755	lipolytic protein G-D-S-L family
I533_07845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_07850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I533_07880	COG1309	transcriptional regulator
I533_07890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_07890	COG0072	phenylalanine-tRNA ligase activity
I533_07920	COG1472	Belongs to the glycosyl hydrolase 3 family
I533_07925	COG2096	Adenosyltransferase
I533_07935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I533_07945	COG4591	ABC-type transport system involved in lipoprotein release permease component
I533_07970	COG0708	Exodeoxyribonuclease III
I533_08005	COG2814	Major facilitator Superfamily
I533_08050	COG1024	Enoyl-CoA hydratase
I533_08055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I533_08060	COG1960	acyl-CoA dehydrogenase activity
I533_08065	COG0789	Transcriptional regulator
I533_08070	COG0183	Belongs to the thiolase family
I533_08085	COG3706	GGDEF domain
I533_08095	COG2925	Exonuclease
I533_08150	COG1643	Atp-dependent helicase
I533_08170	COG3321	synthase
I533_08170	COG0604	alcohol dehydrogenase
I533_08175	COG0328	RNA-DNA hybrid ribonuclease activity
I533_08180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I533_08190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I533_08200	COG4591	ABC-type transport system involved in lipoprotein release permease component
I533_08205	COG1301	dicarboxylic acid transport
I533_08215	COG3724	N-succinylarginine dihydrolase activity
I533_08225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I533_08250	COG0746	molybdenum cofactor guanylyltransferase activity
I533_08255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I533_08260	COG0243	molybdopterin cofactor binding
I533_08265	COG2153	protein acetylation
I533_08280	COG1530	ribonuclease E activity
I533_08285	COG0564	pseudouridine synthase activity
I533_08295	COG0424	maF-like protein
I533_08300	COG1399	metal-binding, possibly nucleic acid-binding protein
I533_08310	COG0416	fatty acid biosynthetic process
I533_08315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I533_08320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I533_08330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I533_08335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I533_08345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I533_08360	COG0084	hydrolase, TatD family'
I533_08370	COG0702	epimerase
I533_08375	COG3706	GGDEF domain
I533_08395	COG1028	Short-chain dehydrogenase reductase Sdr
I533_08400	COG0596	Alpha beta hydrolase
I533_08410	COG0183	Belongs to the thiolase family
I533_08415	COG1960	acyl-CoA dehydrogenase activity
I533_08435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I533_08445	COG0246	Mannitol dehydrogenase
I533_08470	COG0668	transmembrane transport
I533_08475	COG4771	TonB-dependent receptor
I533_08485	COG2198	Histidine kinase
I533_08485	COG2205	protein histidine kinase activity
I533_08485	COG0784	Response regulator, receiver
I533_08490	COG3437	response regulator, receiver
I533_08500	COG0195	Participates in both transcription termination and antitermination
I533_08515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I533_08530	COG1187	pseudouridine synthase activity
I533_08540	COG3153	acetyltransferase
I533_08540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_08580	COG0450	alkyl hydroperoxide reductase
I533_08625	COG1032	radical SAM domain protein
I533_08645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_08655	COG4134	Bacterial extracellular solute-binding protein
I533_08665	COG4136	ATPase activity
I533_08670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I533_08695	COG5001	Diguanylate cyclase
I533_08695	COG2203	Gaf domain
I533_08695	COG4251	negative regulation of phosphorylation
I533_08695	COG3706	GGDEF domain
I533_08740	COG1131	(ABC) transporter
I533_08755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_08760	COG0385	Bile acid
I533_08780	COG0446	pyridine nucleotide-disulphide oxidoreductase
I533_08780	COG1902	pentaerythritol trinitrate reductase activity
I533_08790	COG2867	negative regulation of translational initiation
I533_08795	COG2914	Belongs to the UPF0125 (RnfH) family
I533_08805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_08810	COG4771	TonB-dependent receptor
I533_08815	COG0457	Tetratricopeptide repeat
I533_08830	COG0574	Belongs to the PEP-utilizing enzyme family
I533_08830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I533_08870	COG2850	peptidyl-arginine hydroxylation
I533_08880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I533_08885	COG2915	High frequency lysogenization protein hflD homolog
I533_08890	COG0482	sulfurtransferase activity
I533_08895	COG1187	pseudouridine synthase activity
I533_08905	COG1278	Cold shock
I533_08910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I533_08915	COG0542	response to heat
I533_08920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I533_08925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I533_08930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I533_08935	COG0492	ferredoxin-NADP+ reductase activity
I533_08940	COG3092	negative regulation of chromosome organization
I533_08945	COG3091	SprT-like family
I533_08950	COG0616	signal peptide processing
I533_08965	COG0778	Nitroreductase
I533_08975	COG0252	asparaginase activity
I533_08980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I533_08985	COG0321	lipoyl(octanoyl) transferase activity
I533_08990	COG2921	Belongs to the UPF0250 family
I533_08995	COG1686	Belongs to the peptidase S11 family
I533_09000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I533_09005	COG0772	Belongs to the SEDS family
I533_09010	COG0768	penicillin binding
I533_09015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I533_09020	COG0799	negative regulation of ribosome biogenesis
I533_09030	COG1466	dna polymerase III delta subunit
I533_09035	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I533_09040	COG0495	leucyl-tRNA aminoacylation
I533_09055	COG1067	ATP-dependent peptidase activity
I533_09060	COG0596	Alpha beta hydrolase
I533_09065	COG3706	GGDEF domain
I533_09075	COG1534	Rna-binding protein
I533_09080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I533_09085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I533_09090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I533_09095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I533_09100	COG0149	triose-phosphate isomerase activity
I533_09105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I533_09120	COG1028	Short-chain dehydrogenase reductase Sdr
I533_09125	COG0561	phosphatase activity
I533_09140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_09165	COG1185	polyribonucleotide nucleotidyltransferase activity
I533_09205	COG2856	Zn peptidase
I533_09345	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I533_09350	COG1196	nuclear chromosome segregation
I533_09360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I533_09375	COG1132	(ABC) transporter
I533_09380	COG1663	tetraacyldisaccharide 4'-kinase activity
I533_09415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I533_09420	COG0435	Glutathione S-transferase
I533_09425	COG1741	Belongs to the pirin family
I533_09430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I533_09440	COG0372	Belongs to the citrate synthase family
I533_09445	COG2009	succinate dehydrogenase
I533_09450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I533_09455	COG1053	succinate dehydrogenase
I533_09460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I533_09465	COG0567	Dehydrogenase, E1 component
I533_09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_09505	COG4667	esterase of the alpha-beta hydrolase superfamily
I533_09525	COG0366	Alpha amylase catalytic
I533_09550	COG1028	Short-chain dehydrogenase reductase Sdr
I533_09555	COG2267	carboxylic ester hydrolase activity
I533_09565	COG0616	signal peptide processing
I533_09585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I533_09595	COG0386	Belongs to the glutathione peroxidase family
I533_09600	COG2084	Dehydrogenase
I533_09610	COG1960	acyl-CoA dehydrogenase activity
I533_09615	COG1024	Enoyl-CoA hydratase
I533_09625	COG2226	methyltransferase
I533_09630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I533_09635	COG3083	sulfuric ester hydrolase activity
I533_09640	COG3082	Protein of unknown function (DUF1414)
I533_09645	COG3081	Nucleoid-associated protein
I533_09675	COG3275	phosphorelay sensor kinase activity
I533_09680	COG3279	Response regulator of the LytR AlgR family
I533_09685	COG0205	6-phosphofructokinase activity
I533_09720	COG4221	oxidoreductase activity
I533_09725	COG0583	DNA-binding transcription factor activity
I533_09745	COG2801	Transposase and inactivated derivatives
I533_09775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_09775	COG2205	protein histidine kinase activity
I533_09795	COG0513	Belongs to the DEAD box helicase family
I533_09805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I533_09810	COG0583	DNA-binding transcription factor activity
I533_09830	COG1760	l-serine dehydratase
I533_09855	COG1322	Protein conserved in bacteria
I533_09860	COG1404	Belongs to the peptidase S8 family
I533_09865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I533_09870	COG0022	dehydrogenase e1 component
I533_09880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I533_09885	COG0515	serine threonine protein kinase
I533_09890	COG1946	Acyl-CoA thioesterase
I533_09900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I533_09910	COG1956	GAF domain-containing protein
I533_09925	COG0793	Belongs to the peptidase S41A family
I533_09930	COG0733	neurotransmitter:sodium symporter activity
I533_09940	COG0308	aminopeptidase N
I533_09970	COG2902	Dehydrogenase
I533_09975	COG0167	dihydroorotate dehydrogenase activity
I533_10000	COG3130	regulation of translation
I533_10005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I533_10015	COG0415	Belongs to the DNA photolyase family
I533_10020	COG0415	Belongs to the DNA photolyase family
I533_10025	COG0415	Belongs to the DNA photolyase family
I533_10030	COG3046	protein related to deoxyribodipyrimidine photolyase
I533_10045	COG4974	Belongs to the 'phage' integrase family
I533_10055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I533_10060	COG0589	response to stress
I533_10070	COG0069	glutamate synthase activity
I533_10085	COG2193	ferroxidase activity
I533_10095	COG3278	Belongs to the heme-copper respiratory oxidase family
I533_10110	COG2010	Cytochrome c
I533_10120	COG2217	Heavy metal translocating P-type atpase
I533_10135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I533_10140	COG0589	response to stress
I533_10145	COG0037	tRNA processing
I533_10150	COG1752	Esterase of the alpha-beta hydrolase superfamily
I533_10170	COG1280	lysine exporter protein (LysE YggA)
I533_10175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I533_10180	COG2897	thiosulfate sulfurtransferase activity
I533_10185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I533_10200	COG0322	excinuclease ABC activity
I533_10205	COG2197	response regulator
I533_10210	COG0436	Aminotransferase
I533_10215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I533_10245	COG0556	nucleotide-excision repair
I533_10250	COG4974	Belongs to the 'phage' integrase family
I533_10285	COG0789	Transcriptional regulator
I533_10290	COG3547	Transposase (IS116 IS110 IS902 family)
I533_10300	COG2259	Doxx family
I533_10305	COG0583	DNA-binding transcription factor activity
I533_10320	COG0670	Belongs to the BI1 family
I533_10325	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I533_10340	COG2920	part of a sulfur-relay system
I533_10365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I533_10375	COG0531	amino acid
I533_10375	COG1674	ftsk spoiiie
I533_10385	COG0686	Belongs to the AlaDH PNT family
I533_10390	COG0284	orotidine-5'-phosphate decarboxylase activity
I533_10395	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I533_10410	COG0776	regulation of translation
I533_10415	COG0539	negative regulation of cytoplasmic translation
I533_10420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I533_10425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I533_10430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I533_10440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I533_10445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I533_10450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I533_10455	COG0633	Ferredoxin
I533_10485	COG3344	reverse transcriptase
I533_10495	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I533_10500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I533_10510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I533_10520	COG4783	chaperone-mediated protein folding
I533_10530	COG1393	Belongs to the ArsC family
I533_10545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I533_10560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I533_10570	COG1960	acyl-CoA dehydrogenase activity
I533_10595	COG0572	uridine kinase
I533_10600	COG3769	mannosylglycerate metabolic process
I533_10605	COG1215	transferase activity, transferring glycosyl groups
I533_10610	COG0366	Alpha amylase catalytic
I533_10620	COG0303	'Molybdopterin
I533_10625	COG0534	Mate efflux family protein
I533_10640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I533_10645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I533_10665	COG3547	Transposase (IS116 IS110 IS902 family)
I533_10685	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I533_10705	COG3547	Transposase (IS116 IS110 IS902 family)
I533_10730	COG0405	Gamma-glutamyltransferase
I533_10735	COG1024	Enoyl-CoA hydratase
I533_10780	COG1448	Aminotransferase
I533_10795	COG1671	Belongs to the UPF0178 family
I533_10800	COG1028	Short-chain dehydrogenase reductase Sdr
I533_10805	COG1028	Short-chain dehydrogenase reductase Sdr
I533_10810	COG1960	acyl-CoA dehydrogenase activity
I533_10815	COG2207	Transcriptional regulator
I533_10815	COG0662	Cupin 2, conserved barrel domain protein
I533_10830	COG1505	serine-type exopeptidase activity
I533_10840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_10870	COG0596	Alpha beta hydrolase
I533_10880	COG0716	FMN binding
I533_10905	COG4772	TonB-dependent receptor
I533_10915	COG0735	belongs to the Fur family
I533_10925	COG1984	allophanate hydrolase subunit 2
I533_10930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I533_10935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I533_10940	COG2996	Protein conserved in bacteria
I533_10945	COG1765	OsmC-like protein
I533_10950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_10960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_10975	COG0436	Aminotransferase
I533_10980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_10985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_10995	COG2010	Cytochrome c
I533_10995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_11025	COG1073	alpha beta
I533_11030	COG2207	Transcriptional regulator
I533_11045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_11050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I533_11075	COG3012	SEC-C Motif Domain Protein
I533_11085	COG0604	alcohol dehydrogenase
I533_11095	COG1960	acyl-CoA dehydrogenase activity
I533_11105	COG4771	TonB-dependent receptor
I533_11125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I533_11130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I533_11150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I533_11155	COG0315	cyclic pyranopterin monophosphate synthase activity
I533_11160	COG0521	Mo-molybdopterin cofactor biosynthetic process
I533_11175	COG2161	toxin-antitoxin pair type II binding
I533_11180	COG4115	mRNA cleavage
I533_11195	COG0436	Aminotransferase
I533_11200	COG3268	Saccharopine dehydrogenase
I533_11205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I533_11220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I533_11225	COG4206	TonB-dependent receptor
I533_11235	COG5006	permease, DMT superfamily
I533_11250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I533_11255	COG1074	ATP-dependent DNA helicase activity
I533_11260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I533_11280	COG1022	Amp-dependent synthetase and ligase
I533_11285	COG5001	Diguanylate cyclase
I533_11285	COG4251	negative regulation of phosphorylation
I533_11285	COG3706	GGDEF domain
I533_11285	COG2203	Gaf domain
I533_11305	COG0583	DNA-binding transcription factor activity
I533_11325	COG0640	Transcriptional regulator
I533_11345	COG2204	response regulator
I533_11355	COG4251	negative regulation of phosphorylation
I533_11360	COG0784	Response regulator, receiver
I533_11365	COG2205	protein histidine kinase activity
I533_11365	COG0784	Response regulator, receiver
I533_11390	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I533_11415	COG3139	Protein of unknown function (DUF1315)
I533_11430	COG1115	amino acid carrier protein
I533_11435	COG2866	Carboxypeptidase
I533_11455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I533_11465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I533_11470	COG1640	4-alpha-glucanotransferase
I533_11475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I533_11480	COG0676	glucose-6-phosphate 1-epimerase activity
I533_11485	COG0800	Aldolase
I533_11495	COG0129	dihydroxy-acid dehydratase activity
I533_11505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_11510	COG1737	Transcriptional regulator
I533_11515	COG0469	pyruvate kinase activity
I533_11530	COG1960	acyl-CoA dehydrogenase activity
I533_11550	COG0490	domain, Protein
I533_11550	COG0471	metal ion transport
I533_11575	COG0129	dihydroxy-acid dehydratase activity
I533_11585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_11590	COG1737	Transcriptional regulator
I533_11595	COG0469	pyruvate kinase activity
I533_11600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_11620	COG2823	Periplasmic or secreted lipoprotein
I533_11645	COG3665	Urea carboxylase-associated protein
I533_11680	COG2356	endonuclease I
I533_11700	COG0583	DNA-binding transcription factor activity
I533_11705	COG1979	alcohol dehydrogenase
I533_11720	COG3437	response regulator, receiver
I533_11720	COG0784	Response regulator, receiver
I533_11725	COG4191	Histidine kinase
I533_11725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I533_11735	COG0471	metal ion transport
I533_11745	COG0489	protein tyrosine kinase activity
I533_11750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_11750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I533_11755	COG0668	transmembrane transport
I533_11760	COG2226	methyltransferase
I533_11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_11770	COG1388	LysM domain
I533_11770	COG0741	lytic transglycosylase activity
I533_11780	COG0215	cysteine-tRNA ligase activity
I533_11785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I533_11790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I533_11800	COG2268	Band 7 protein
I533_11815	COG1733	regulation of RNA biosynthetic process
I533_11820	COG0604	alcohol dehydrogenase
I533_11825	COG0753	catalase activity
I533_11830	COG0604	alcohol dehydrogenase
I533_11835	COG0583	DNA-binding transcription factor activity
I533_11870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I533_11875	COG1286	toxin biosynthetic process
I533_11880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I533_11885	COG0285	dihydrofolate synthase activity
I533_11905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I533_11910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I533_11930	COG3609	addiction module antidote protein, CC2985 family
I533_11940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I533_11950	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I533_11950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I533_11995	COG0789	Transcriptional regulator
I533_12000	COG0604	alcohol dehydrogenase
I533_12020	COG1119	ATPase activity
I533_12025	COG2031	fatty acid transporter
I533_12030	COG2205	protein histidine kinase activity
I533_12030	COG5002	protein histidine kinase activity
I533_12030	COG0784	Response regulator, receiver
I533_12040	COG0612	Peptidase, M16
I533_12055	COG3101	peptidyl-lysine hydroxylation
I533_12080	COG0446	pyridine nucleotide-disulphide oxidoreductase
I533_12080	COG1902	pentaerythritol trinitrate reductase activity
I533_12105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I533_12115	COG4399	Belongs to the UPF0754 family
I533_12140	COG1770	oligopeptidase
I533_12145	COG2186	Transcriptional regulator
I533_12155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I533_12160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I533_12170	COG2983	Belongs to the UPF0260 family
I533_12175	COG0179	Fumarylacetoacetate (FAA) hydrolase
I533_12190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I533_12195	COG0318	PFAM AMP-dependent synthetase and ligase
I533_12200	COG2267	carboxylic ester hydrolase activity
I533_12215	COG1214	PFAM Peptidase M22, glycoprotease
I533_12220	COG1199	ATP-dependent helicase activity
I533_12270	COG4771	TonB-dependent receptor
I533_12280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I533_12285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I533_12290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I533_12295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I533_12295	COG0131	Imidazoleglycerol-phosphate dehydratase
I533_12300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I533_12315	COG0140	phosphoribosyl-ATP diphosphatase activity
I533_12315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I533_12320	COG2116	formate transmembrane transporter activity
I533_12325	COG0840	transmembrane signaling receptor activity
I533_12360	COG0326	Molecular chaperone. Has ATPase activity
I533_12365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I533_12385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I533_12390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I533_12400	COG3220	belongs to the UPF0276 family
I533_12410	COG1136	(ABC) transporter
I533_12410	COG0577	efflux transmembrane transporter activity
I533_12420	COG5001	Diguanylate cyclase
I533_12420	COG3706	GGDEF domain
I533_12420	COG4251	negative regulation of phosphorylation
I533_12420	COG2203	Gaf domain
I533_12430	COG1183	phosphatidylcholine synthase activity
I533_12450	COG0277	FAD linked oxidase domain protein
I533_12455	COG0542	response to heat
I533_12465	COG0564	pseudouridine synthase activity
I533_12480	COG1595	DNA-templated transcription, initiation
I533_12495	COG4221	oxidoreductase activity
I533_12510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I533_12520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I533_12530	COG0142	geranyltranstransferase activity
I533_12540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I533_12545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I533_12555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I533_12570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I533_12570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I533_12590	COG0488	(ABC) transporter
I533_12600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I533_12610	COG0560	Phosphoserine phosphatase
I533_12620	COG0084	hydrolase, TatD family'
I533_12635	COG0571	ribonuclease III activity
I533_12640	COG0681	Belongs to the peptidase S26 family
I533_12665	COG1595	DNA-templated transcription, initiation
I533_12670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I533_12685	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I533_12765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I533_12770	COG1047	Peptidyl-prolyl cis-trans
I533_12780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I533_12785	COG0196	riboflavin kinase activity
I533_12790	COG0728	peptidoglycan biosynthetic process
I533_12795	COG0268	Binds directly to 16S ribosomal RNA
I533_12810	COG1028	Short-chain dehydrogenase reductase Sdr
I533_12815	COG0385	Bile acid
I533_12820	COG0583	DNA-binding transcription factor activity
I533_12840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_12845	COG0776	regulation of translation
I533_12855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I533_12860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I533_12865	COG0740	serine-type endopeptidase activity
I533_12870	COG0544	peptidyl-prolyl cis-trans isomerase activity
I533_12885	COG1720	tRNA m6t6A37 methyltransferase activity
I533_12895	COG1234	tRNA 3'-trailer cleavage
I533_12905	COG0123	including yeast histone deacetylase and acetoin utilization protein
I533_12920	COG0517	IMP dehydrogenase activity
I533_12920	COG0516	GMP reductase activity
I533_12925	COG1570	exodeoxyribonuclease VII activity
I533_12945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I533_12950	COG2976	Protein conserved in bacteria
I533_12975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I533_12985	COG2166	iron-sulfur cluster assembly
I533_13000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I533_13005	COG0719	Fe-S assembly protein
I533_13010	COG0396	ATPase activity
I533_13015	COG0719	Fe-S assembly protein
I533_13020	COG1104	cysteine desulfurase activity
I533_13030	COG2072	flavoprotein involved in K transport
I533_13035	COG1045	serine acetyltransferase
I533_13040	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I533_13045	COG0483	inositol monophosphate 1-phosphatase activity
I533_13060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I533_13065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I533_13070	COG1862	Preprotein translocase
I533_13075	COG0343	queuine tRNA-ribosyltransferase activity
I533_13095	COG1842	Phage shock protein A
I533_13100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I533_13120	COG0754	glutathionylspermidine amidase activity
I533_13150	COG2066	Belongs to the glutaminase family
I533_13155	COG1785	Belongs to the alkaline phosphatase family
I533_13195	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I533_13300	COG0438	transferase activity, transferring glycosyl groups
I533_13325	COG0438	transferase activity, transferring glycosyl groups
I533_13350	COG0367	asparagine synthase
I533_13355	COG0438	transferase activity, transferring glycosyl groups
I533_13375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I533_13390	COG0489	protein tyrosine kinase activity
I533_13400	COG3409	Peptidoglycan-binding domain 1 protein
I533_13400	COG3267	Type II secretory pathway component ExeA
I533_13405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I533_13405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I533_13410	COG2827	Endonuclease containing a URI domain
I533_13435	COG1560	Kdo2-lipid A biosynthetic process
I533_13465	COG1960	acyl-CoA dehydrogenase activity
I533_13480	COG3300	MHYT domain
I533_13480	COG5001	Diguanylate cyclase
I533_13485	COG1435	thymidine kinase activity
I533_13495	COG1609	Transcriptional regulator
I533_13500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I533_13525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I533_13530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I533_13535	COG1024	Enoyl-CoA hydratase
I533_13535	COG1250	3-hydroxyacyl-CoA dehydrogenase
I533_13550	COG1012	belongs to the aldehyde dehydrogenase family
I533_13570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I533_13595	COG1960	acyl-CoA dehydrogenase activity
I533_13625	COG0745	RESPONSE REGULATOR receiver
I533_13630	COG2205	protein histidine kinase activity
I533_13670	COG2080	2 iron, 2 sulfur cluster binding
I533_13675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I533_13680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I533_13700	COG1028	Short-chain dehydrogenase reductase Sdr
I533_13710	COG4221	oxidoreductase activity
I533_13715	COG0693	protein deglycase activity
I533_13720	COG1295	ribonuclease BN
I533_13730	COG4681	YaeQ
I533_13760	COG2814	Major facilitator Superfamily
I533_13775	COG0514	ATP-dependent DNA helicase (RecQ)
I533_13805	COG4251	negative regulation of phosphorylation
I533_13810	COG2133	pyrroloquinoline quinone binding
I533_13830	COG0830	nickel cation binding
I533_13855	COG0829	nickel cation binding
I533_13860	COG0410	ABC transporter
I533_13895	COG0745	RESPONSE REGULATOR receiver
I533_13900	COG3177	Filamentation induced by cAMP protein fic
I533_13920	COG4942	peptidase
I533_13930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I533_13945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I533_13970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I533_13975	COG2971	BadF BadG BcrA BcrD
I533_13980	COG0583	DNA-binding transcription factor activity
I533_13985	COG1620	l-lactate permease
I533_14010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_14015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I533_14020	COG0006	proline dipeptidase activity
I533_14030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_14045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I533_14050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I533_14055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I533_14075	COG3313	Fe-S protein
I533_14105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_14110	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_14115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I533_14120	COG2186	Transcriptional regulator
I533_14130	COG3023	N-Acetylmuramoyl-L-alanine amidase
I533_14135	COG3577	Aspartyl protease
I533_14140	COG0157	Belongs to the NadC ModD family
I533_14150	COG1459	type II secretion system
I533_14160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I533_14160	COG0237	dephospho-CoA kinase activity
I533_14165	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I533_14175	COG3608	succinylglutamate desuccinylase aspartoacylase
I533_14180	COG0494	nUDIX hydrolase
I533_14190	COG0739	heme binding
I533_14195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I533_14200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I533_14205	COG0849	cell division
I533_14210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I533_14215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I533_14220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I533_14230	COG0772	Belongs to the SEDS family
I533_14235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I533_14245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I533_14250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I533_14255	COG0768	penicillin binding
I533_14260	COG3116	cell division
I533_14270	COG2001	Belongs to the MraZ family
I533_14290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I533_14315	COG0678	peroxiredoxin activity
I533_14315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I533_14330	COG3706	GGDEF domain
I533_14340	COG2204	response regulator
I533_14345	COG2205	protein histidine kinase activity
I533_14345	COG0784	Response regulator, receiver
I533_14375	COG0668	transmembrane transport
I533_14380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I533_14385	COG0189	ligase activity
I533_14390	COG1678	Uncharacterized ACR, COG1678
I533_14395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I533_14420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I533_14425	COG0762	integral membrane protein
I533_14435	COG1902	pentaerythritol trinitrate reductase activity
I533_14435	COG0446	pyridine nucleotide-disulphide oxidoreductase
I533_14450	COG0625	glutathione transferase activity
I533_14460	COG1764	response to oxidative stress
I533_14465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I533_14480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I533_14490	COG2814	Major facilitator Superfamily
I533_14495	COG0724	RNA recognition motif
I533_14525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I533_14530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I533_14535	COG0083	homoserine kinase activity
I533_14550	COG0583	DNA-binding transcription factor activity
I533_14565	COG0640	Transcriptional regulator
I533_14575	COG0431	NADPH-dependent FMN reductase
I533_14580	COG0798	PFAM Bile acid sodium symporter
I533_14585	COG2201	protein-glutamate methylesterase activity
I533_14590	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I533_14600	COG0642	Histidine kinase
I533_14625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I533_14650	COG1748	Saccharopine dehydrogenase
I533_14665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I533_14670	COG3107	peptidoglycan biosynthetic process
I533_14680	COG0438	transferase activity, transferring glycosyl groups
I533_14690	COG2823	Periplasmic or secreted lipoprotein
I533_14710	COG4585	Histidine kinase
I533_14715	COG2197	response regulator
I533_14730	COG4771	TonB-dependent receptor
I533_14740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I533_14745	COG0372	Belongs to the citrate synthase family
I533_14750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I533_14755	COG2828	Protein conserved in bacteria
I533_14760	COG2199	diguanylate cyclase activity
I533_14760	COG2203	Gaf domain
I533_14780	COG0784	Response regulator, receiver
I533_14780	COG5002	protein histidine kinase activity
I533_14780	COG2198	Histidine kinase
I533_14785	COG3023	N-Acetylmuramoyl-L-alanine amidase
I533_14790	COG0069	glutamate synthase activity
I533_14790	COG0070	glutamate synthase
I533_14790	COG0067	glutamate synthase
I533_14795	COG0493	'glutamate synthase
I533_14810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_14815	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I533_14820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I533_14825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I533_14840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I533_14845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I533_14855	COG4942	peptidase
I533_14860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I533_14865	COG0738	Major facilitator superfamily
I533_14875	COG1902	pentaerythritol trinitrate reductase activity
I533_14895	COG0625	glutathione transferase activity
I533_14920	COG2894	cell division
I533_14925	COG0850	regulation of cytokinetic process
I533_14935	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I533_14965	COG1914	H( )-stimulated, divalent metal cation uptake system
I533_14970	COG0436	Aminotransferase
I533_14990	COG0174	glutamine synthetase
I533_15000	COG3852	Histidine kinase
I533_15005	COG2204	response regulator
I533_15010	COG3437	response regulator, receiver
I533_15015	COG0204	Acyl-transferase
I533_15055	COG4999	Histidine kinase
I533_15055	COG3850	Histidine kinase
I533_15055	COG3437	response regulator, receiver
I533_15055	COG2205	protein histidine kinase activity
I533_15060	COG0525	valine-tRNA ligase activity
I533_15065	COG2927	DNA polymerase III (CHI subunit)
I533_15070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I533_15075	COG0795	lipopolysaccharide-transporting ATPase activity
I533_15080	COG0795	lipopolysaccharide-transporting ATPase activity
I533_15160	COG2856	Zn peptidase
I533_15250	COG0673	inositol 2-dehydrogenase activity
I533_15265	COG0628	permease
I533_15280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I533_15285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I533_15290	COG4558	Periplasmic binding protein
I533_15300	COG4206	TonB-dependent receptor
I533_15315	COG0149	triose-phosphate isomerase activity
I533_15320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I533_15325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I533_15340	COG3842	ATPase activity
I533_15375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I533_15380	COG0697	spore germination
I533_15415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I533_15430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I533_15435	COG3706	GGDEF domain
I533_15435	COG0745	RESPONSE REGULATOR receiver
I533_15440	COG0679	Auxin Efflux Carrier
I533_15475	COG1131	(ABC) transporter
I533_15485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I533_15495	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I533_15535	COG2205	protein histidine kinase activity
I533_15545	COG3901	Regulator of nitric oxide reductase transcription
I533_15545	COG0348	domain, Protein
I533_15555	COG2197	response regulator
I533_15580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I533_15585	COG0277	FAD linked oxidase domain protein
I533_15595	COG1462	curli production assembly transport component CsgG
I533_15625	COG2197	response regulator
I533_15640	COG0513	Belongs to the DEAD box helicase family
I533_15645	COG5001	Diguanylate cyclase
I533_15660	COG0800	Aldolase
I533_15665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_15680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I533_15680	COG3264	Mechanosensitive ion channel
I533_15720	COG0730	response to heat
I533_15740	COG4191	Histidine kinase
I533_15750	COG0417	DNA replication proofreading
I533_15760	COG0318	PFAM AMP-dependent synthetase and ligase
I533_15780	COG1309	transcriptional regulator
I533_15790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_15800	COG1573	uracil-dna glycosylase
I533_15805	COG5001	Diguanylate cyclase
I533_15805	COG3300	MHYT domain
I533_15825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I533_15845	COG1983	PspC domain protein
I533_15850	COG1842	Phage shock protein A
I533_15860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I533_15880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I533_15880	COG2885	chlorophyll binding
I533_15885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I533_15895	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I533_15900	COG0204	Acyl-transferase
I533_15905	COG0204	Acyl-transferase
I533_15910	COG0668	transmembrane transport
I533_15925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_15930	COG0733	neurotransmitter:sodium symporter activity
I533_15945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I533_15960	COG0716	FMN binding
I533_15970	COG0848	biopolymer transport protein
I533_15990	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I533_16005	COG1215	transferase activity, transferring glycosyl groups
I533_16020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I533_16025	COG0702	epimerase
I533_16040	COG5001	Diguanylate cyclase
I533_16040	COG5002	protein histidine kinase activity
I533_16055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I533_16065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_16075	COG0583	DNA-binding transcription factor activity
I533_16080	COG0121	glutamine amidotransferase
I533_16085	COG4682	membrane
I533_16105	COG1953	Uracil, thiamine, allantoin
I533_16110	COG4771	TonB-dependent receptor
I533_16120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I533_16125	COG0778	Nitroreductase
I533_16130	COG0596	Alpha beta hydrolase
I533_16135	COG0251	oxidation-reduction process
I533_16140	COG1335	isochorismatase
I533_16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_16150	COG1309	transcriptional regulator
I533_16165	COG4628	conserved protein (DUF2132)
I533_16190	COG1609	Transcriptional regulator
I533_16195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I533_16205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I533_16215	COG1477	protein flavinylation
I533_16220	COG2871	sodium ion transport
I533_16225	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_16230	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_16235	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_16240	COG1805	sodium ion transport
I533_16245	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I533_16250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I533_16255	COG0545	Peptidyl-prolyl cis-trans isomerase
I533_16260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I533_16265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I533_16265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I533_16280	COG0039	L-malate dehydrogenase activity
I533_16285	COG1438	arginine binding
I533_16310	COG0572	uridine kinase
I533_16315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I533_16335	COG3706	GGDEF domain
I533_16335	COG0745	RESPONSE REGULATOR receiver
I533_16340	COG2176	DNA-directed DNA polymerase activity
I533_16350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I533_16370	COG0189	ligase activity
I533_16380	COG0189	ligase activity
I533_16380	COG4067	protein conserved in archaea
I533_16405	COG1283	sodium-dependent phosphate transmembrane transporter activity
I533_16410	COG0667	Aldo Keto reductase
I533_16445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I533_16455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I533_16460	COG0840	transmembrane signaling receptor activity
I533_16480	COG2274	protein secretion by the type I secretion system
I533_16485	COG0583	DNA-binding transcription factor activity
I533_16510	COG1091	dTDP-4-dehydrorhamnose reductase activity
I533_16540	COG1051	belongs to the nudix hydrolase family
I533_16545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I533_16575	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I533_16645	COG0110	maltose O-acetyltransferase activity
I533_16680	COG1216	Glycosyl transferase, family 2
I533_16680	COG0438	transferase activity, transferring glycosyl groups
I533_16735	COG0438	transferase activity, transferring glycosyl groups
I533_16735	COG1216	Glycosyl transferase, family 2
I533_16760	COG2161	toxin-antitoxin pair type II binding
I533_16770	COG0202	RNA polymerase activity
I533_16795	COG0201	protein transport
I533_16815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I533_16850	COG0784	Response regulator, receiver
I533_16850	COG5002	protein histidine kinase activity
I533_16875	COG0557	exoribonuclease II activity
I533_16905	COG4771	TonB-dependent receptor
I533_16920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I533_16935	COG0543	2 iron, 2 sulfur cluster binding
I533_16950	COG2234	aminopeptidase activity
I533_16960	COG4251	negative regulation of phosphorylation
I533_16970	COG1271	oxidase subunit
I533_16975	COG1294	oxidase, subunit
I533_16985	COG1522	sequence-specific DNA binding
I533_16995	COG1278	Cold shock
I533_17000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I533_17020	COG0339	signal peptide processing
I533_17025	COG2201	protein-glutamate methylesterase activity
I533_17035	COG3852	Histidine kinase
I533_17045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I533_17050	COG0243	molybdopterin cofactor binding
I533_17055	COG1506	peptidase
I533_17055	COG4946	Tricorn protease homolog
I533_17055	COG0823	Involved in the tonB-independent uptake of proteins
I533_17105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I533_17115	COG2197	response regulator
I533_17125	COG0189	ligase activity
I533_17145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I533_17150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I533_17155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I533_17170	COG0281	malic enzyme
I533_17180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I533_17210	COG0456	acetyltransferase
I533_17220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I533_17225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I533_17230	COG2177	Part of the ABC transporter FtsEX involved in
I533_17235	COG2884	Cell division ATP-binding protein ftsE
I533_17240	COG0552	protein localization to endoplasmic reticulum
I533_17245	COG0742	ribosomal rna small subunit methyltransferase
I533_17255	COG2095	MarC family integral membrane protein
I533_17275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I533_17280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_17285	COG0617	tRNA 3'-terminal CCA addition
I533_17290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I533_17305	COG0076	glutamate decarboxylase activity
I533_17320	COG0842	Transport permease protein
I533_17325	COG1131	(ABC) transporter
I533_17330	COG0745	RESPONSE REGULATOR receiver
I533_17335	COG2205	protein histidine kinase activity
I533_17340	COG4774	siderophore transport
I533_17360	COG1253	flavin adenine dinucleotide binding
I533_17370	COG1966	Carbon starvation protein
I533_17395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I533_17400	COG0049	tRNA binding
I533_17405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I533_17410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I533_17415	COG0085	RNA polymerase activity
I533_17420	COG0222	ribosome binding
I533_17425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I533_17430	COG0081	regulation of translation
I533_17435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I533_17455	COG0250	Participates in transcription elongation, termination and antitermination
I533_17460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I533_17465	COG1132	(ABC) transporter
I533_17470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I533_17475	COG3590	peptidase
I533_17485	COG0513	Belongs to the DEAD box helicase family
I533_17490	COG0418	dihydroorotase activity
I533_17495	COG3040	lipid binding
I533_17500	COG4989	oxidoreductase activity
I533_17505	COG0346	lactoylglutathione lyase activity
I533_17510	COG0668	transmembrane transport
I533_17530	COG0302	gtp cyclohydrolase
I533_17540	COG2957	Belongs to the agmatine deiminase family
I533_17545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I533_17555	COG1201	RNA secondary structure unwinding
I533_17565	COG1793	dna ligase
I533_17570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I533_17575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I533_17590	COG0625	glutathione transferase activity
I533_17595	COG0625	glutathione transferase activity
I533_17605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I533_17620	COG1012	belongs to the aldehyde dehydrogenase family
I533_17625	COG0028	Belongs to the TPP enzyme family
I533_17635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I533_17640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I533_17645	COG0330	HflC and HflK could
I533_17650	COG0330	HflC and HflK could
I533_17655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I533_17660	COG1923	regulation of RNA biosynthetic process
I533_17665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I533_17680	COG0802	atpase or kinase
I533_17685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I533_17685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I533_17690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I533_17700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I533_17710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I533_17715	COG0735	belongs to the Fur family
I533_17725	COG0432	Pfam Uncharacterised protein family UPF0047
I533_17735	COG0305	Participates in initiation and elongation during chromosome replication
I533_17760	COG2258	MOSC domain
I533_17790	COG2205	protein histidine kinase activity
I533_17790	COG2198	Histidine kinase
I533_17790	COG0784	Response regulator, receiver
I533_17800	COG1136	(ABC) transporter
I533_17810	COG0840	transmembrane signaling receptor activity
I533_17815	COG5002	protein histidine kinase activity
I533_17820	COG0840	transmembrane signaling receptor activity
I533_17850	COG1472	Belongs to the glycosyl hydrolase 3 family
I533_17860	COG2723	6-phospho-beta-galactosidase activity
I533_17865	COG1609	Transcriptional regulator
I533_17870	COG2814	Major facilitator Superfamily
I533_17875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I533_17880	COG4988	ABC transporter
I533_17885	COG4890	Cyd operon protein YbgT
I533_17890	COG1294	oxidase, subunit
I533_17905	COG2204	response regulator
I533_17930	COG4319	ketosteroid isomerase
I533_17950	COG2375	cellular response to nickel ion
I533_17955	COG3237	CsbD-like
I533_17990	COG0596	Alpha beta hydrolase
I533_17990	COG0508	dehydrogenase complex catalyzes the overall conversion of
I533_18010	COG3038	cytochrome b561
I533_18020	COG1252	NADH dehydrogenase
I533_18035	COG0583	DNA-binding transcription factor activity
I533_18040	COG2067	long-chain fatty acid transport protein
I533_18045	COG2130	NADP-dependent
I533_18050	COG5001	Diguanylate cyclase
I533_18050	COG4251	negative regulation of phosphorylation
I533_18050	COG3706	GGDEF domain
I533_18050	COG2203	Gaf domain
I533_18055	COG0784	Response regulator, receiver
I533_18055	COG2205	protein histidine kinase activity
I533_18065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I533_18125	COG0701	Predicted permease
I533_18170	COG0789	Transcriptional regulator
I533_18200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I533_18205	COG1349	DNA-binding transcription factor activity
I533_18210	COG0673	inositol 2-dehydrogenase activity
I533_18225	COG0697	spore germination
I533_18230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I533_18235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I533_18240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I533_18245	COG1166	arginine decarboxylase activity
I533_18255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I533_18260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I533_18265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I533_18310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I533_18320	COG0109	protoheme IX farnesyltransferase activity
I533_18340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I533_18385	COG3030	protein affecting phage T7 exclusion by the F plasmid
I533_18390	COG1324	tolerance protein
I533_18395	COG4232	protein-disulfide reductase activity
I533_18400	COG0739	heme binding
I533_18405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I533_18410	COG0511	ligase activity, forming carbon-carbon bonds
I533_18415	COG0439	Biotin carboxylase
I533_18460	COG0154	amidase activity
I533_18475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I533_18480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I533_18495	COG0151	Belongs to the GarS family
I533_18510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I533_18515	COG3954	Phosphoribulokinase
I533_18525	COG0745	RESPONSE REGULATOR receiver
I533_18545	COG1501	Belongs to the glycosyl hydrolase 31 family
I533_18555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I533_18565	COG3031	protein transport across the cell outer membrane
I533_18575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I533_18580	COG1459	type II secretion system
I533_18585	COG2165	general secretion pathway protein
I533_18590	COG2165	general secretion pathway protein
I533_18595	COG2165	general secretion pathway protein
I533_18600	COG4795	General secretion pathway protein
I533_18615	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I533_18630	COG1012	belongs to the aldehyde dehydrogenase family
I533_18640	COG1011	Hydrolase
I533_18645	COG0494	nUDIX hydrolase
I533_18650	COG1218	3'(2'),5'-bisphosphate nucleotidase
I533_18665	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I533_18675	COG3089	Belongs to the UPF0270 family
I533_18680	COG0429	hydrolase of the alpha beta-hydrolase fold
I533_18690	COG0488	(ABC) transporter
I533_18710	COG2900	Belongs to the SlyX family
I533_18720	COG0545	Peptidyl-prolyl cis-trans isomerase
I533_18730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I533_18735	COG2183	response to ionizing radiation
I533_18755	COG0596	Alpha beta hydrolase
I533_18760	COG1040	competence protein
I533_18780	COG1794	racemase activity, acting on amino acids and derivatives
I533_18790	COG0534	Mate efflux family protein
I533_18795	COG0726	polysaccharide deacetylase
I533_18795	COG1649	PFAM Uncharacterised BCR, COG1649
I533_18805	COG1999	signal sequence binding
I533_18810	COG0109	protoheme IX farnesyltransferase activity
I533_18815	COG1612	heme a metabolic process
I533_18835	COG1845	cytochrome c oxidase, subunit III
I533_18840	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I533_18845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I533_18850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I533_18870	COG0129	dihydroxy-acid dehydratase activity
I533_18880	COG0606	chelatase, subunit chli
I533_18885	COG0583	DNA-binding transcription factor activity
I533_18895	COG2814	Major facilitator Superfamily
I533_18905	COG0729	surface antigen
I533_18910	COG2911	Protein conserved in bacteria
I533_18935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I533_18945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I533_18965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I533_18990	COG1228	amidohydrolase
I533_19015	COG0425	Belongs to the sulfur carrier protein TusA family
I533_19035	COG1561	YicC-like family, N-terminal region
I533_19045	COG3550	peptidyl-serine autophosphorylation
I533_19050	COG3620	sequence-specific DNA binding
I533_19075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I533_19090	COG4771	TonB-dependent receptor
I533_19100	COG3119	arylsulfatase activity
I533_19105	COG0714	Associated with various cellular activities
I533_19120	COG2304	oxidoreductase activity
I533_19155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I533_19165	COG1960	acyl-CoA dehydrogenase activity
I533_19175	COG1024	Enoyl-CoA hydratase
I533_19185	COG2801	Transposase and inactivated derivatives
I533_19210	COG0129	dihydroxy-acid dehydratase activity
I533_19220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I533_19225	COG1737	Transcriptional regulator
I533_19230	COG0469	pyruvate kinase activity
I533_19235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I533_19270	COG3177	Filamentation induced by cAMP protein fic
I533_19285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I533_19300	COG0706	membrane insertase activity
I533_19305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I533_19310	COG0594	ribonuclease P activity
I533_19315	COG0230	Belongs to the bacterial ribosomal protein bL34 family