locus-tag	class	description
I876_00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
I876_00015	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
I876_00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
I876_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
I876_00035	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
I876_00040	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
I876_00045	ENOG4108R3E	Dna-3-methyladenine glycosylase i
I876_00055	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
I876_00065	ENOG4106RE7	Cytochrome
I876_00070	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
I876_00075	ENOG4105C2M	dna polymerase I
I876_00080	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
I876_00085	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
I876_00090	ENOG4105C1A	potassium transporter peripheral membrane
I876_00095	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
I876_00100	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
I876_00105	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
I876_00115	ENOG4105C79	DNA protecting protein DprA
I876_00120	ENOG4108RPN	Protein smg homolog
I876_00130	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
I876_00135	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
I876_00140	ENOG4105EIF	outer membrane protein W
I876_00150	ENOG4105E2X	shikimate dehydrogenase
I876_00155	ENOG4108Z0R	Transferase
I876_00190	ENOG4105C0B	DNA polymerase III (alpha subunit)
I876_00220	ENOG4105IIU	Aminopeptidase
I876_00225	ENOG4106WTF	Glycosyl transferase, family 2
I876_00230	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
I876_00235	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
I876_00240	ENOG4105W5Q	DNA repair protein (RadC
I876_00260	ENOG4105E3R	(LipO)protein
I876_00265	ENOG4105KDC	50s ribosomal protein l28
I876_00270	ENOG4105W0E	50S ribosomal protein L33
I876_00280	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
I876_00285	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
I876_00290	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
I876_00295	ENOG4105DKP	glycosyl transferase, family 9
I876_00310	ENOG4105BZU	Histidine kinase
I876_00315	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
I876_00320	ENOG4105CPQ	Dehydrogenase
I876_00325	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
I876_00340	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
I876_00345	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
I876_00360	ENOG4105W0Z	cytoplasmic protein
I876_00365	ENOG4105C4R	Atp-dependent dna helicase
I876_00370	ENOG4105BZU	Histidine kinase
I876_00375	ENOG4105MPD	Cytochrome
I876_00395	ENOG4105DFD	Na H antiporter
I876_00415	ENOG4108VCT	Sulfite exporter TauE/SafE
I876_00430	ENOG4105D05	Receptor
I876_00445	ENOG4108JJ8	(ABC) transporter
I876_00450	ENOG4108JJ9	ABC, transporter
I876_00460	ENOG4105C4M	(Ubiquinol oxidase) subunit I
I876_00470	ENOG4105VFE	sira family
I876_00480	ENOG4105D3R	alkyl hydroperoxide reductase
I876_00490	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I876_00520	ENOG4105C94	Transporter
I876_00550	ENOG4105D0S	secretion protein (HlyD
I876_00555	ENOG4105CJ1	ABC, transporter
I876_00560	ENOG4105CMI	transporter
I876_00575	ENOG4105C1G	acyl-Coa dehydrogenase
I876_00580	ENOG4105DQS	Transcriptional regulator
I876_00590	ENOG4105CM6	amino acid regulated cytosolic protein
I876_00610	ENOG4105D41	biosynthesis protein thiH
I876_00615	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
I876_00625	ENOG4105D06	uba thif-type nad fad binding protein
I876_00630	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
I876_00635	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
I876_00640	ENOG410601J	HemY protein
I876_00645	ENOG4105ECF	c-methyltransferase
I876_00650	ENOG41076E6	Uroporphyrinogen-III Synthase
I876_00655	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
I876_00675	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
I876_00680	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
I876_00685	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
I876_00690	ENOG4105KME	endoribonuclease L-psp
I876_00695	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
I876_00700	ENOG4105CB5	ATP-dependent DNA helicase recG
I876_00705	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
I876_00725	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
I876_00730	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
I876_00740	ENOG4105CBX	hi0933 family
I876_00775	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
I876_00780	ENOG4105BZS	acriflavin resistance protein
I876_00790	ENOG4105CYC	Transferase
I876_00810	ENOG4108N3W	hemolysin secretion protein
I876_00820	ENOG4108NST	exported protein
I876_00825	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
I876_00830	ENOG4105BZU	Histidine kinase
I876_00845	ENOG4105C9U	ATP-dependent DNA helicase RecQ
I876_00850	ENOG4105CJW	magnesium transporter
I876_00855	ENOG4105FR1	rard protein
I876_00860	ENOG4105BZU	Histidine kinase
I876_00865	ENOG4105C4R	Atp-dependent dna helicase
I876_00870	ENOG4105D7W	serine acetyltransferase
I876_00875	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
I876_00880	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
I876_00890	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
I876_00895	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
I876_00915	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
I876_00940	ENOG4105EXC	Acyl-transferase
I876_00950	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
I876_00955	ENOG4105DFU	Cell wall formation (By similarity)
I876_00960	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I876_00970	ENOG4105F0N	pyrophosphate phospho-hydrolase
I876_01000	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
I876_01015	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
I876_01020	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
I876_01030	ENOG4107XMK	single-stranded DNA-binding protein
I876_01045	ENOG4105CNT	hydrolase family 2
I876_01065	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
I876_01070	ENOG4105E98	transcriptional regulator DeoR family
I876_01075	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
I876_01125	ENOG4107QHF	type ii secretion system protein e
I876_01130	ENOG4105D7Q	type ii secretion system
I876_01175	ENOG4105DFF	Rod shape-determining protein mreb
I876_01180	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
I876_01185	ENOG4105VQ7	Rod shape-determining protein MreD
I876_01190	ENOG4108Z03	MAF-like protein
I876_01195	ENOG4105C03	ribonuclease
I876_01210	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
I876_01215	ENOG4105N42	UPF0307 protein
I876_01220	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
I876_01230	ENOG4105CNT	hydrolase family 2
I876_01235	ENOG41065U4	response regulator
I876_01240	ENOG4105BZU	Histidine kinase
I876_01245	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
I876_01250	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
I876_01255	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
I876_01260	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
I876_01265	ENOG4105CEN	a g-specific adenine glycosylase
I876_01270	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
I876_01275	ENOG4105MUN	Divergent AAA domain
I876_01355	ENOG4105FE5	Homospermidine synthase
I876_01360	ENOG4105IBP	Cyclic peptide transporter
I876_01380	ENOG4105WQT	MbtH domain protein
I876_01530	ENOG4105PGM	cation diffusion facilitator family transporter
I876_01540	ENOG41080IJ	Diacylglycerol kinase
I876_01545	ENOG4105DIJ	Phosphoethanolamine transferase
I876_01550	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
I876_01560	ENOG4105CKK	Glycosyl transferase, family 2
I876_01570	ENOG4105GR3	Histidine kinase
I876_01625	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
I876_01630	ENOG4105GR3	Histidine kinase
I876_01635	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
I876_01660	ENOG4108IJF	Heavy metal efflux pump, CzcA
I876_01740	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
I876_01755	ENOG4107JPU	
I876_01760	ENOG4108USZ	hydrogenase
I876_01770	ENOG4105E3S	small subunit
I876_01790	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
I876_01795	ENOG4107RSS	Hydrogenase accessory protein HypB
I876_01800	ENOG4105CQS	hydrogenase expression formation protein HypD
I876_01810	ENOG4105C45	hydrogenase expression formation protein (HypE)
I876_01820	ENOG4105C59	p-type ATPase
I876_01915	ENOG4107R7I	amino acid
I876_01925	ENOG4105E3B	Multicopper oxidase
I876_01950	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_01955	ENOG4108VYJ	response regulator receiver protein
I876_01960	ENOG4105CBS	Chea signal transduction histidine kinase
I876_01965	ENOG4108V3W	Chemotaxis protein, CheW
I876_01970	ENOG4107SDU	Methyl-accepting chemotaxis
I876_01975	ENOG4105BZU	Histidine kinase
I876_01980	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
I876_01990	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_01995	ENOG4108VYJ	response regulator receiver protein
I876_02000	ENOG4105CBS	Chea signal transduction histidine kinase
I876_02005	ENOG4108V3W	Chemotaxis protein, CheW
I876_02010	ENOG4107SDU	Methyl-accepting chemotaxis
I876_02015	ENOG4107SDU	Methyl-accepting chemotaxis
I876_02020	ENOG4105BZU	Histidine kinase
I876_02025	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
I876_02055	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
I876_02080	ENOG4105ETE	Transcriptional regulator (LacI family
I876_02095	ENOG4105EAA	nucleoside
I876_02120	ENOG4105C0A	alcohol dehydrogenase
I876_02125	ENOG4105CM2	brancheD-chain amino acid aminotransferase
I876_02130	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
I876_02140	ENOG4107QM5	aconitate hydratase
I876_02150	ENOG4107QHF	type ii secretion system protein e
I876_02160	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
I876_02165	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
I876_02170	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
I876_02175	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I876_02180	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
I876_02185	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
I876_02190	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
I876_02195	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
I876_02200	ENOG41083MP	50s ribosomal protein l29
I876_02205	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
I876_02210	ENOG4107RJ7	Glycosyl transferase (Group 1
I876_02220	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
I876_02240	ENOG41069D7	Methyl-accepting chemotaxis
I876_02245	ENOG4105DGW	oligopeptidase A
I876_02265	ENOG4105CQ7	ATP-dependent helicase
I876_02270	ENOG4105CVE	Lytic murein transglycosylase
I876_02275	ENOG4105BZ4	penicillin-binding protein
I876_02290	ENOG4105CKW	Inner membrane protein yedI
I876_02295	ENOG4108XW0	May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF
I876_02305	ENOG4108YZA	Nitrogen regulatory protein pii
I876_02315	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
I876_02320	ENOG4105EZR	dyp-type peroxidase family protein
I876_02330	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
I876_02335	ENOG4105CXT	aspartate transcarbamylase
I876_02360	ENOG4105BZU	Histidine kinase
I876_02365	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
I876_02390	ENOG4105C26	Dehydrogenase
I876_02400	ENOG4105C8Y	Acetylornithine aminotransferase
I876_02415	ENOG4105C31	Tryptophanyl-tRNA synthetase
I876_02420	ENOG4105DJV	ribulose-phosphate 3-epimerase
I876_02440	ENOG4105DFE	Dna adenine methylase
I876_02450	ENOG4105D49	3-dehydroquinate synthase
I876_02455	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
I876_02460	ENOG4105E4G	Type IV pilus
I876_02485	ENOG4108JQC	penicillin-binding protein 1A
I876_02490	ENOG4107R1I	NAD-dependent malic enzyme
I876_02505	ENOG4105CYM	Glutathione S-transferase
I876_02515	ENOG4105CH6	catalase
I876_02530	ENOG4105BZU	Histidine kinase
I876_02535	ENOG4107QZM	n-acetylglutamate synthase
I876_02540	ENOG4105CH7	arginosuccinase
I876_02545	ENOG4105CDH	Citrulline--aspartate ligase
I876_02555	ENOG4105CAS	nag kinase
I876_02560	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
I876_02565	ENOG4108Z5K	methylglyoxal synthase
I876_02575	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
I876_02580	ENOG4105E0F	Histidine kinase
I876_02585	ENOG4108EUD	Lysophospholipase
I876_02590	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
I876_02600	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
I876_02605	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
I876_02610	ENOG4105VW4	glutaredoxin 3
I876_02615	ENOG4107YZP	Rhodanese domain protein
I876_02620	ENOG41063SB	peptidase
I876_02625	ENOG4105PXI	polysaccharide deacetylase
I876_02645	ENOG4105DJ4	phosphatidylserine decarboxylase
I876_02650	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
I876_02655	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
I876_02675	ENOG4105C7K	acetolactate synthase
I876_02680	ENOG4108ZP8	Acetolactate synthase small subunit
I876_02695	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
I876_02700	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
I876_02705	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
I876_02715	ENOG4105F8V	Hydrolase, tatD family
I876_02725	ENOG4105D52	delta-aminolevulinic acid dehydratase
I876_02730	ENOG4105C9X	ppx gppa phosphatase
I876_02735	ENOG4105C1J	atp-dependent rna helicase
I876_02740	ENOG4105K63	Thioredoxin
I876_02750	ENOG4105CH2	amidohydrolase
I876_02755	ENOG4105BZU	Histidine kinase
I876_02760	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
I876_02765	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
I876_02770	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
I876_02790	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
I876_02800	ENOG4107QR8	Thioredoxin
I876_02820	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
I876_02825	ENOG4105C26	Dehydrogenase
I876_02840	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
I876_02845	ENOG4107S6Z	Na H antiporter
I876_02860	ENOG4105EHZ	conserved protein UCP016719
I876_02865	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I876_02870	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
I876_02885	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
I876_02900	ENOG4105K3M	)-transporter
I876_02910	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
I876_02915	ENOG4105I4A	GCN5-related N-acetyltransferase
I876_02940	ENOG41084S7	Plasmid maintenance system antidote protein
I876_02955	ENOG4105K4U	addiction module toxin, RelE StbE family
I876_03010	ENOG4105KVH	Transcriptional regulator
I876_03030	ENOG4105CHU	acetyl-coa acetyltransferase
I876_03035	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
I876_03040	ENOG4107SC1	transglycosylase
I876_03045	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
I876_03055	ENOG4105EAH	synthase
I876_03060	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
I876_03065	ENOG4105K46	50S ribosomal protein l27
I876_03070	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I876_03085	ENOG4108K5P	(LipO)protein
I876_03090	ENOG4108UM1	dedA family
I876_03095	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
I876_03100	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
I876_03105	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
I876_03110	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
I876_03115	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
I876_03125	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_03165	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
I876_03170	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
I876_03175	ENOG4105HF0	Membrane
I876_03180	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
I876_03185	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
I876_03195	ENOG4105BZU	Histidine kinase
I876_03215	ENOG4105D3G	Pseudouridine synthase
I876_03220	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
I876_03235	ENOG4108IAB	Phoh family
I876_03245	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
I876_03250	ENOG4105C1J	atp-dependent rna helicase
I876_03270	ENOG4105DFG	type I secretion outer membrane protein
I876_03275	ENOG41087AY	ADP-Ribose pyrophosphatase
I876_03285	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
I876_03290	ENOG4105IPS	esterase
I876_03295	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
I876_03305	ENOG4107VXZ	Hydrolase
I876_03330	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
I876_03335	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
I876_03340	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
I876_03345	ENOG4105UGU	tonB-dependent Receptor
I876_03355	ENOG41068WN	
I876_03360	ENOG4105CNM	Receptor
I876_03370	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
I876_03375	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
I876_03385	ENOG4105M85	Bola protein
I876_03415	ENOG4105CHH	sulfate transporter
I876_03420	ENOG4107QZF	nitrite reductase NADPH large subunit
I876_03435	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
I876_03440	ENOG4108I0Q	anthranilate phosphoribosyltransferase
I876_03445	ENOG4107SDU	Methyl-accepting chemotaxis
I876_03460	ENOG4105D7T	ABC transporter
I876_03475	ENOG4108Z33	Thiol disulfide Interchange Protein
I876_03480	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
I876_03485	ENOG4105E27	serine threonine protein kinase
I876_03490	ENOG4105C58	cytochrome c oxidase accessory protein ccog
I876_03505	ENOG4105CSU	acyl-Coa dehydrogenase
I876_03510	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
I876_03520	ENOG4105CXK	mandelate racemase muconate lactonizing
I876_03525	ENOG4105MP9	class II Aldolase
I876_03535	ENOG410624X	efflux transporter, rnd family, mfp subunit
I876_03540	ENOG4105BZS	acriflavin resistance protein
I876_03555	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_03560	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
I876_03565	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
I876_03580	ENOG4105VCC	30S ribosomal protein S21
I876_03585	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
I876_03595	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
I876_03600	ENOG4107ZVW	dihydroneopterin aldolase
I876_03610	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
I876_03615	ENOG4105K59	histidine triad (HIT) protein
I876_03630	ENOG4105DKK	Benzoate
I876_03635	ENOG4108JCI	Transcriptional regulator
I876_03640	ENOG4105DH7	May be involved in recombination (By similarity)
I876_03645	ENOG4105BZU	Histidine kinase
I876_03650	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
I876_03655	ENOG4105BZU	Histidine kinase
I876_03690	ENOG4109015	Biopolymer transport protein exbD tolR
I876_03695	ENOG41067XB	TonB family
I876_03705	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_03710	ENOG4105BZU	Histidine kinase
I876_03715	ENOG4105CEY	Amp-dependent synthetase and ligase
I876_03730	ENOG4107QIJ	Aconitate hydratase 2
I876_03740	ENOG4107RZZ	dna polymerase iii epsilon subunit
I876_03745	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
I876_03760	ENOG4107QIJ	Aconitate hydratase 2
I876_03770	ENOG4105CFH	Aspartokinase
I876_03775	ENOG4108NVR	Methyl-accepting chemotaxis
I876_03780	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
I876_03785	ENOG4105NWN	ApaG protein
I876_03790	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
I876_03795	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
I876_03800	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
I876_03805	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
I876_03810	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
I876_03815	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
I876_03820	ENOG4105T95	Thiol disulfide interChange protein
I876_03825	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
I876_03835	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
I876_03840	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
I876_03845	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
I876_03850	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
I876_03855	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
I876_03860	ENOG4105DXN	mazG family
I876_03895	ENOG4105CEY	Amp-dependent synthetase and ligase
I876_03905	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
I876_03915	ENOG4105CKK	Glycosyl transferase, family 2
I876_03935	ENOG4105DHQ	Histidine kinase
I876_03950	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
I876_03955	ENOG4108UJD	30S ribosomal protein S9
I876_03960	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
I876_03965	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
I876_03970	ENOG4105EIX	cytochrome c1
I876_03975	ENOG4107MKT	Stringent starvation protein a
I876_03980	ENOG4105KB2	stringent starvation protein b
I876_03985	ENOG4105CJW	magnesium transporter
I876_03990	ENOG41080Z8	PHOSPHOCARRIER protein
I876_03995	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
I876_04000	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
I876_04005	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
I876_04010	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
I876_04015	ENOG4108IUZ	ABC transporter
I876_04020	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
I876_04030	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
I876_04035	ENOG4105C2X	Arabinose 5-phosphate isomerase
I876_04045	ENOG4105DHJ	ABC, transporter
I876_04050	ENOG4105CY3	ABC transporter, permease
I876_04055	ENOG4107PE3	Mammalian cell entry related domain protein
I876_04060	ENOG4105E3I	toluene tolerance
I876_04070	ENOG4105VFK	BolA family
I876_04075	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
I876_04080	ENOG4105C0H	protease
I876_04085	ENOG4105C0H	protease
I876_04095	ENOG4105D6Z	AFG1 family ATPase
I876_04100	ENOG4105CDY	transcriptional regulatory protein
I876_04130	ENOG4105D05	Receptor
I876_04135	ENOG4108RNG	Permease of the drug metabolite transporter
I876_04145	ENOG4105BZU	Histidine kinase
I876_04165	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
I876_04170	ENOG4105CV1	Transketolase (EC 2.2.1.1)
I876_04175	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
I876_04180	ENOG4105BZA	Phosphoglycerate kinase
I876_04185	ENOG4105WYW	fructose-bisphosphate aldolase
I876_04195	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
I876_04210	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
I876_04215	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
I876_04220	ENOG4105C9X	ppx gppa phosphatase
I876_04235	ENOG4105C8U	phosphate abc transporter
I876_04245	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
I876_04255	ENOG4105CJ3	phosphate transporter
I876_04265	ENOG4105C5Q	Transcriptional regulator
I876_04275	ENOG4108UT2	hemolysin iii
I876_04280	ENOG4105K56	Transcriptional regulator
I876_04285	ENOG4108ZHJ	Organic hydroperoxide resistance protein
I876_04300	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
I876_04310	ENOG4107RH8	nuclease SbcCD subunit D
I876_04315	ENOG4105EYH	Exonuclease
I876_04325	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
I876_04345	ENOG4105CZE	histidine utilization repressor
I876_04350	ENOG4105CGP	Urocanate hydratase
I876_04355	ENOG4105C84	Histidine ammonia-lyase
I876_04385	ENOG4105C5H	ABC transporter
I876_04410	ENOG4105D64	Mechanosensitive ion channel
I876_04465	ENOG41067MG	lrgb family
I876_04495	ENOG4105CSA	Coproporphyrinogen iii oxidase
I876_04505	ENOG4105C1J	atp-dependent rna helicase
I876_04510	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
I876_04525	ENOG4105CPI	Metal Dependent Phosphohydrolase
I876_04530	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
I876_04535	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
I876_04540	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
I876_04545	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
I876_04555	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
I876_04560	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
I876_04565	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
I876_04575	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
I876_04580	ENOG4108IUW	ABC transporter
I876_04585	ENOG4108SDH	ABC, transporter
I876_04600	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
I876_04605	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
I876_04610	ENOG41060IM	Heme exporter protein
I876_04615	ENOG4105X3C	heme exporter protein
I876_04620	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
I876_04625	ENOG4105DA4	cytochrome c-type biogenesis protein
I876_04630	ENOG4107QX9	Thiol disulfide interChange protein
I876_04635	ENOG4108M1T	Cytochrome c-type biogenesis protein
I876_04645	ENOG410903C	(LipO)protein
I876_04650	ENOG4105CMR	udp-glucose 4-epimerase
I876_04660	ENOG4105DUX	Transporter
I876_04690	ENOG4105ESV	Glycosyl transferase, family 4
I876_04705	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
I876_04710	ENOG4105KQC	Competence protein
I876_04715	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
I876_04730	ENOG4105EWT	decarboxylase family
I876_04735	ENOG4105BZU	Histidine kinase
I876_04740	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
I876_04745	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
I876_04780	ENOG4105DR9	pseudouridine synthase
I876_04785	ENOG4105QDK	Flavodoxin
I876_04790	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
I876_04795	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
I876_04800	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
I876_04805	ENOG4105CE9	30S ribosomal protein S2
I876_04810	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
I876_04815	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
I876_04820	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
I876_04825	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
I876_04830	ENOG4105KNE	Phosphatidate cytidylyltransferase
I876_04835	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
I876_04845	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_04850	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
I876_04855	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
I876_04860	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
I876_04865	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
I876_04870	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
I876_04875	ENOG4105C0B	DNA polymerase III (alpha subunit)
I876_04880	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
I876_04885	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
I876_04890	ENOG4105BZU	Histidine kinase
I876_04905	ENOG4108Z6B	deaminase
I876_04915	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
I876_04920	ENOG4108ETH	Formylglycinamide ribotide synthetase
I876_04930	ENOG4108DG9	Smr protein MutS2
I876_05030	ENOG4107QIZ	NADH dehydrogenase
I876_05040	ENOG4107QIZ	NADH dehydrogenase
I876_05055	ENOG4105CZE	histidine utilization repressor
I876_05060	ENOG4105DWD	nucleoside recognition domain protein
I876_05075	ENOG4105CGP	Urocanate hydratase
I876_05080	ENOG4105CZE	histidine utilization repressor
I876_05085	ENOG4105CI2	imidazolone-5-propionate hydrolase
I876_05090	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
I876_05125	ENOG4105CDV	Ompa motb domain protein
I876_05130	ENOG4108JJA	ABC, transporter
I876_05140	ENOG4105WH1	Two component transcriptional regulator luxr family
I876_05180	ENOG4107R88	Chemotaxis protein (CheV)
I876_05185	ENOG4105BZU	Histidine kinase
I876_05190	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
I876_05195	ENOG4108ZC9	flagellar basal-body rod protein flgc
I876_05200	ENOG4105W00	Flagellar hook capping protein
I876_05205	ENOG4105BZE	flagellar hook protein, FlgE
I876_05210	ENOG4108KPB	Flagellar basal-body rod protein FlgF
I876_05215	ENOG4105CGA	flagellar basal-body rod protein FlgG
I876_05220	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
I876_05225	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
I876_05230	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
I876_05235	ENOG4105E1Q	flagellar hook-associated protein
I876_05250	ENOG4105I03	Flagellin
I876_05255	ENOG4105I03	Flagellin
I876_05260	ENOG4105I03	Flagellin
I876_05265	ENOG41063QE	flagellar protein FlaG
I876_05275	ENOG4105MQ3	flagellar protein FliS
I876_05300	ENOG4105D2T	synthase
I876_05305	ENOG4107DKY	pseudaminic acid biosynthesis-associated protein PseG
I876_05310	ENOG4105F0R	Cytidylyltransferase
I876_05315	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
I876_05320	ENOG4105C5E	polysaccharide biosynthesis protein
I876_05330	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_05335	ENOG4105BZU	Histidine kinase
I876_05340	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_05345	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
I876_05350	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
I876_05355	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
I876_05365	ENOG4108JIR	Flagellum-specific ATP synthase
I876_05385	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
I876_05390	ENOG4105DD5	Flagellar motor switch protein
I876_05395	ENOG4105VTB	flagellar biosynthesis protein fliO
I876_05400	ENOG4105CN7	Flagellar biosynthetic protein FliP
I876_05405	ENOG4105VS8	Flagellar biosynthetic protein fliq
I876_05410	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
I876_05415	ENOG4105D00	flagellar biosynthetic protein flhB
I876_05420	ENOG4105D7B	Flagellar biosynthesis protein flha
I876_05425	ENOG4105FZW	flagellar biosynthesis regulator FlhF
I876_05435	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
I876_05440	ENOG4108VYJ	response regulator receiver protein
I876_05445	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
I876_05450	ENOG4105CBS	Chea signal transduction histidine kinase
I876_05460	ENOG4107QJE	Chromosome Partitioning Protein
I876_05470	ENOG4105YFD	chemotaxis, protein
I876_05480	ENOG4105CVG	Homoserine O-transsuccinylase
I876_05485	ENOG4105C3R	Methionine synthase
I876_05490	ENOG4105C3R	Methionine synthase
I876_05500	ENOG4105NBK	UPF0345 protein
I876_05505	ENOG4105DZ2	Transcriptional regulator
I876_05510	ENOG4105C5Q	Transcriptional regulator
I876_05515	ENOG4107B2H	carbonic anhydrase
I876_05520	ENOG4105CHH	sulfate transporter
I876_05535	ENOG4105C9K	Endothelin-converting enzyme 1
I876_05545	ENOG4108004	Modulates RecA activity (By similarity)
I876_05550	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
I876_05555	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
I876_05570	ENOG4107QSA	Oxaloacetate decarboxylase
I876_05575	ENOG4105D9Q	decarboxylase (Beta subunit)
I876_05580	ENOG4108JQ2	peptide transport system atp-binding protein
I876_05585	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
I876_05590	ENOG4108EU3	peptide transport system, permease
I876_05595	ENOG4108I5W	peptide transport system, permease protein
I876_05600	ENOG4105DEF	Extracellular solute-binding protein, family 5
I876_05605	ENOG4105E51	psp operon transcriptional activator
I876_05610	ENOG41087YS	Phage shock protein A
I876_05625	ENOG4105MIR	Phenylalanine 4-monooxygenase
I876_05640	ENOG4108RXX	maleylacetoacetate isomerase
I876_05645	ENOG4108XM1	transcriptional regulator AsnC family
I876_05660	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
I876_05720	ENOG4109015	Biopolymer transport protein exbD tolR
I876_05725	ENOG410822N	TonB family
I876_05735	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
I876_05770	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
I876_05780	ENOG4105HEI	LysR family (Transcriptional regulator
I876_05785	ENOG4105F27	Major Facilitator
I876_05795	ENOG4105CV8	reductase
I876_05810	ENOG4107MII	Sugar-specific transcriptional regulator TrmB
I876_05830	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
I876_05835	ENOG4105C75	arginyL-tRNA synthetase
I876_05865	ENOG4105BZU	Histidine kinase
I876_05870	ENOG4108KBJ	Inner membrane protein YkgB
I876_05890	ENOG4105F57	Anthranilate dioxygenase reductase
I876_05900	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
I876_05905	ENOG4105CRK	lysyL-tRNA synthetase
I876_05910	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
I876_05915	ENOG4108W1A	pseudouridine synthase
I876_05930	ENOG4105D9M	gamma-glutamylcysteine synthetase
I876_05955	ENOG4108DG9	Smr protein MutS2
I876_05960	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
I876_05965	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
I876_05975	ENOG4105ED1	spovr family
I876_05980	ENOG4106AKX	UPF0229 protein
I876_05985	ENOG4105CYN	Serine protein kinase
I876_05990	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
I876_05995	ENOG4105M2J	Glutaredoxin
I876_06000	ENOG4105D05	Receptor
I876_06025	ENOG4105D3R	alkyl hydroperoxide reductase
I876_06030	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
I876_06035	ENOG4105EIY	sodium-type flagellar protein motY
I876_06040	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
I876_06045	ENOG4108UYE	Lactoylglutathione lyase
I876_06050	ENOG4105VEQ	Cold shock protein
I876_06070	ENOG4105DZB	Electron transport complex
I876_06075	ENOG4108UQQ	Electron transport complex
I876_06080	ENOG4105D6A	Electron transport complex
I876_06090	ENOG4108R3D	Electron transport complex
I876_06095	ENOG4105DGN	Electron transport complex
I876_06100	ENOG4107QJQ	Mate efflux family protein
I876_06105	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
I876_06115	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
I876_06120	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
I876_06130	ENOG4105CAQ	asparagine synthetase
I876_06160	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
I876_06165	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
I876_06170	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
I876_06175	ENOG4105C11	sulfate adenylyltransferase), subunit 2
I876_06180	ENOG4105CK7	Sodium proline symporter
I876_06185	ENOG4105BZU	Histidine kinase
I876_06210	ENOG4107QVM	von Willebrand factor, type A
I876_06230	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
I876_06235	ENOG4105CHU	acetyl-coa acetyltransferase
I876_06240	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
I876_06255	ENOG4105BZU	Histidine kinase
I876_06265	ENOG4108BY2	phosphohistidine phosphatase
I876_06275	ENOG4108JU6	CBS domain protein
I876_06280	ENOG4106KVJ	cytochrome C assembly protein
I876_06285	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I876_06335	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
I876_06340	ENOG4105BZ1	(ABC) transporter
I876_06355	ENOG4105K5M	30s ribosomal protein S16
I876_06360	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
I876_06365	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
I876_06370	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
I876_06375	ENOG4105EN6	Membrane
I876_06380	ENOG4105E39	Enoyl-CoA hydratase
I876_06385	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
I876_06405	ENOG4108ZJT	translation initiation factor, Sui1
I876_06415	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
I876_06425	ENOG4105BZU	Histidine kinase
I876_06435	ENOG4107WP9	Histidine kinase
I876_06445	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_06450	ENOG4105I03	Flagellin
I876_06465	ENOG4105C9M	aspartyl-trna synthetase
I876_06470	ENOG4108TIT	dATP pyrophosphohydrolase
I876_06475	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
I876_06480	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
I876_06485	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
I876_06490	ENOG4107YD3	Thioesterase
I876_06495	ENOG4105E02	MotA TolQ exbB proton channel
I876_06500	ENOG4105M8F	Biopolymer transport protein exbD tolR
I876_06510	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
I876_06515	ENOG4105KCK	Peptidoglycan-associated lipoprotein
I876_06520	ENOG4105UFD	tol-pal system protein YbgF
I876_06525	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
I876_06535	ENOG4108NRW	Phospholipase, patatin family
I876_06540	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
I876_06560	ENOG4105DS1	cytochrome b561
I876_06565	ENOG4105BZU	Histidine kinase
I876_06590	ENOG4108VKG	metal-dependent hydrolase
I876_06600	ENOG4105BZS	acriflavin resistance protein
I876_06610	ENOG4108XG4	DNA-binding transcriptional regulator
I876_06615	ENOG4108ESX	Receptor
I876_06635	ENOG4105BZU	Histidine kinase
I876_06645	ENOG4105DY2	Paraquat-inducible protein b
I876_06650	ENOG4105F1S	paraquat-inducible protein a
I876_06665	ENOG4105C5S	asparaginyl-tRNA synthetase
I876_06680	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
I876_06700	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
I876_06705	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
I876_06710	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
I876_06715	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
I876_06720	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
I876_06725	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
I876_06730	ENOG4105KJF	protein tyrosine phosphatase
I876_06735	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
I876_06740	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
I876_06745	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
I876_06760	ENOG4108JJ7	ABC transporter
I876_06765	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
I876_06775	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
I876_06780	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
I876_06800	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
I876_06815	ENOG4108UJV	acyl-CoA thioesterase i
I876_06820	ENOG4108I0Y	(ABC) transporter
I876_06825	ENOG4105CV6	ABC transporter, permease
I876_06830	ENOG4105ECP	epimerase
I876_06835	ENOG4105KKP	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase
I876_06840	ENOG4105DSF	transport protein
I876_06850	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
I876_06865	ENOG4105K9H	YciI-like protein
I876_06870	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
I876_06875	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
I876_06880	ENOG4105DK0	Indole-3-glycerol phosphate synthase
I876_06885	ENOG4108I0Q	anthranilate phosphoribosyltransferase
I876_06895	ENOG4105CRQ	synthase (Component I)
I876_06900	ENOG4105DB7	PHP domain protein
I876_06905	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
I876_06910	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
I876_06915	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
I876_06920	ENOG4105FE9	pseudouridine synthase
I876_06925	ENOG4105CV8	reductase
I876_06930	ENOG4108UW5	maltose o-acetyltransferase
I876_06940	ENOG4106BRA	Membrane
I876_06945	ENOG4105FQ6	thiopurine methyltransferase
I876_06950	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
I876_06955	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
I876_06960	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
I876_06965	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
I876_06970	ENOG4105C0A	alcohol dehydrogenase
I876_06975	ENOG4105DTD	Dehydrogenase
I876_06985	ENOG4105DWV	Homoserine O-trans-acetylase
I876_06990	ENOG4105CY2	Citrate transporter
I876_07005	ENOG4105BZU	Histidine kinase
I876_07010	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I876_07015	ENOG4105CFG	Acts as a chaperone (By similarity)
I876_07020	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
I876_07025	ENOG41085AF	Cytochrome
I876_07030	ENOG4108M8H	domain protein
I876_07035	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
I876_07045	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
I876_07050	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
I876_07055	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
I876_07060	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
I876_07080	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
I876_07085	ENOG4105C6K	Malic enzyme
I876_07100	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
I876_07105	ENOG4108JU5	Magnesium and cobalt efflux protein
I876_07110	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
I876_07115	ENOG4105C9A	Phoh family
I876_07120	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
I876_07125	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
I876_07160	ENOG4107RNH	Outer membrane receptor FepA
I876_07165	ENOG4108S4H	thioesterase Superfamily protein
I876_07170	ENOG4107XWI	flavin reductase domain protein, FMN-binding
I876_07180	ENOG4105BZG	amino acid carrier protein
I876_07190	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
I876_07195	ENOG4105C3G	gtp-binding protein
I876_07200	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
I876_07205	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
I876_07210	ENOG4105DQ4	alcohol dehydrogenase
I876_07225	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
I876_07230	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
I876_07235	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
I876_07240	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
I876_07245	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
I876_07250	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
I876_07255	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_07265	ENOG4108YY7	Invasion gene expression up-regulator SirB
I876_07270	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
I876_07280	ENOG4105ETT	transcriptional Regulator, LysR family
I876_07290	ENOG4105M08	Membrane
I876_07295	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
I876_07300	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
I876_07305	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
I876_07310	ENOG4107TPY	serine threonine protein kinase
I876_07315	ENOG4105TMB	Formate nitrite transporter
I876_07320	ENOG4105F8C	transglutaminase domain-containing protein
I876_07330	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
I876_07335	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
I876_07340	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
I876_07345	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
I876_07350	ENOG4105BZU	Histidine kinase
I876_07355	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
I876_07365	ENOG4105K8R	UPF0145 protein
I876_07385	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
I876_07390	ENOG4105KUZ	arsenate reductase
I876_07400	ENOG4107RBJ	symporter
I876_07420	ENOG4105F1J	Homogentisate 1,2-dioxygenase
I876_07455	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
I876_07475	ENOG4105BZU	Histidine kinase
I876_07490	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
I876_07510	ENOG4105BZU	Histidine kinase
I876_07520	ENOG4107QUY	Guanine deaminase
I876_07540	ENOG4105C7W	Xanthine dehydrogenase
I876_07555	ENOG4108R86	Transcriptional regulator
I876_07570	ENOG4105C7N	Xanthine uracil vitamin C permease
I876_07575	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
I876_07585	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_07600	ENOG4105BZU	Histidine kinase
I876_07615	ENOG4105C2W	permease
I876_07630	ENOG4105C5R	Aminotransferase
I876_07635	ENOG4105HF0	Membrane
I876_07640	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
I876_07680	ENOG4105CHR	reductase
I876_07690	ENOG4105C22	threonyL-tRNA synthetase
I876_07695	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
I876_07700	ENOG41082NX	50s ribosomal protein l35
I876_07705	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
I876_07730	ENOG4105DAY	polysaccharide export protein
I876_07735	ENOG4108QV3	biosynthesis protein
I876_07740	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
I876_07765	ENOG4105BZU	Histidine kinase
I876_07775	ENOG4107QPH	glycogen) synthase
I876_07790	ENOG4108SHN	Glycosyl transferase, family 2
I876_07795	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
I876_07800	ENOG4107R4N	Cell wall formation (By similarity)
I876_07805	ENOG4107T8Q	Glycosyl transferase (Group 1
I876_07830	ENOG4107QPH	glycogen) synthase
I876_07840	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
I876_07845	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
I876_07850	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
I876_07860	ENOG4108Z66	YbaK ebsC protein
I876_07870	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
I876_07875	ENOG4108WBT	adenosyltransferase
I876_07885	ENOG4108JA2	transcriptioN-repair coupling factor
I876_07895	ENOG4105D60	lipoprotein releasing system transmembrane protein
I876_07920	ENOG4105CGK	Exodeoxyribonuclease III
I876_07955	ENOG4105DNH	Major Facilitator
I876_07965	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
I876_07990	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
I876_08000	ENOG4108UKI	Enoyl-CoA hydratase
I876_08005	ENOG4107QX3	carboxylase
I876_08010	ENOG4105C1G	acyl-Coa dehydrogenase
I876_08015	ENOG4108Z6Z	Transcriptional regulator
I876_08020	ENOG4105CHU	acetyl-coa acetyltransferase
I876_08035	ENOG4105BZU	Histidine kinase
I876_08045	ENOG4105CJB	Exodeoxyribonuclease I
I876_08050	ENOG4105BZU	Histidine kinase
I876_08105	ENOG4105CQ7	ATP-dependent helicase
I876_08120	ENOG4105DR4	Methyltransferase
I876_08125	ENOG4108JA1	polyketide synthase
I876_08130	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
I876_08135	ENOG4107RZZ	dna polymerase iii epsilon subunit
I876_08145	ENOG4108M8H	domain protein
I876_08155	ENOG4105D60	lipoprotein releasing system transmembrane protein
I876_08170	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
I876_08180	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
I876_08205	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
I876_08210	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
I876_08215	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
I876_08220	ENOG4107YB6	acetyltransferase, (GNAT) family
I876_08235	ENOG4105C03	ribonuclease
I876_08240	ENOG4105EI2	Pseudouridine synthase
I876_08250	ENOG4108UHJ	MAF-like protein
I876_08255	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
I876_08260	ENOG4105VGS	50s ribosomal protein l32
I876_08265	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
I876_08270	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
I876_08275	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
I876_08280	ENOG4105CHR	reductase
I876_08285	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
I876_08290	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
I876_08300	ENOG4105HHA	aminodeoxychorismate lyase
I876_08305	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
I876_08310	ENOG4107QRG	dna polymerase iii
I876_08315	ENOG4105F8V	Hydrolase, tatD family
I876_08330	ENOG4105BZU	Histidine kinase
I876_08350	ENOG4105CHR	reductase
I876_08355	ENOG4108J2P	Alpha beta hydrolase fold
I876_08365	ENOG4105CHU	acetyl-coa acetyltransferase
I876_08370	ENOG4105CSU	acyl-Coa dehydrogenase
I876_08385	ENOG4105DKT	Transcriptional regulator
I876_08390	ENOG4107UB3	HAD-superfamily hydrolase subfamily IA variant 3
I876_08400	ENOG4105DEI	Mannitol dehydrogenase
I876_08425	ENOG4105D8X	mechanosensitive ion channel
I876_08430	ENOG4105D05	Receptor
I876_08435	ENOG4105KZX	Pterin carbinolamine dehydratase
I876_08440	ENOG4105BZU	Histidine kinase
I876_08445	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_08450	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
I876_08455	ENOG4105CHV	Transcription elongation factor NusA
I876_08460	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
I876_08465	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
I876_08470	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
I876_08480	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
I876_08485	ENOG4105FE9	pseudouridine synthase
I876_08495	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
I876_08535	ENOG4105D3R	alkyl hydroperoxide reductase
I876_08580	ENOG4105CCT	upf0313 protein
I876_08595	ENOG4105D05	Receptor
I876_08600	ENOG4107QN2	dihydrolipoyl dehydrogenase
I876_08610	ENOG4105VNH	ABC transporter solute-binding protein
I876_08620	ENOG4108VGW	abc transporter atp-binding protein
I876_08625	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
I876_08695	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
I876_08700	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
I876_08705	ENOG4108Z1B	Cyclase dehydrase
I876_08710	ENOG4105VDB	UPF0125 protein
I876_08720	ENOG4105C94	Transporter
I876_08735	ENOG4107RDJ	Sulfotransferase
I876_08745	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
I876_08750	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
I876_08790	ENOG4105EZE	Cupin 4 family protein
I876_08800	ENOG4107QTF	adenylosuccinate lyase
I876_08805	ENOG41075W9	High frequency lysogenization protein HflD homolog
I876_08810	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
I876_08815	ENOG4108R99	pseudouridine synthase
I876_08825	ENOG4105VEQ	Cold shock protein
I876_08830	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
I876_08835	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
I876_08840	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
I876_08845	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
I876_08850	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
I876_08855	ENOG4105C3M	thioredoxin reductase
I876_08860	ENOG4105PQ6	UPF0208 membrane protein
I876_08865	ENOG4105GPY	SprT protein
I876_08870	ENOG4105D07	Signal peptide peptidase, SppA
I876_08885	ENOG41069NU	Nitroreductase
I876_08895	ENOG4105HDK	L-asparaginase
I876_08900	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
I876_08905	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
I876_08910	ENOG4108Z43	UPF0250 protein
I876_08915	ENOG4105DZ1	carboxypeptidase
I876_08920	ENOG4105K6T	rare lipoprotein A
I876_08925	ENOG4105CNI	cell division protein FtsW
I876_08930	ENOG4105CJN	penicillin-binding protein
I876_08935	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
I876_08940	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
I876_08945	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
I876_08950	ENOG4105DJF	DNA polymerase III, delta' subunit
I876_08955	ENOG4108U2H	Rare lipoprotein B
I876_08960	ENOG4105C8T	Leucyl-tRNA synthetase
I876_08975	ENOG4105DAN	ATP-dependent protease
I876_08980	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
I876_08985	ENOG4105BZU	Histidine kinase
I876_08995	ENOG4105HBR	Rna-binding protein
I876_09000	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
I876_09005	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
I876_09010	ENOG4105EEI	dihydropteroate synthase
I876_09015	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
I876_09020	ENOG4105CP7	Triose-phosphate isomerase
I876_09030	ENOG4105BZU	Histidine kinase
I876_09060	ENOG4105CHR	reductase
I876_09065	ENOG4108KP7	hydrolase
I876_09080	ENOG4105CK7	Sodium proline symporter
I876_09090	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
I876_09105	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
I876_09140	ENOG4105EQR	Transposase IS116 IS110 IS902
I876_09150	ENOG4105EQR	Transposase IS116 IS110 IS902
I876_09255	ENOG4105JAB	phenazine biosynthesis protein, phzf family
I876_09355	ENOG410822N	TonB family
I876_09385	ENOG4105EXN	Sulfate transport protein CysZ
I876_09390	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
I876_09395	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
I876_09400	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
I876_09415	ENOG4105BZ1	(ABC) transporter
I876_09420	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
I876_09425	ENOG4105W49	UPF0434 protein
I876_09430	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
I876_09440	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
I876_09455	ENOG4105CUZ	uba thif-type nad fad binding protein
I876_09460	ENOG4105CHF	Glutathione S-transferase
I876_09465	ENOG4105EUB	pirin domain protein
I876_09470	ENOG4107QKV	phosphomannomutase
I876_09480	ENOG4105BZN	citrate synthase
I876_09485	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
I876_09490	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
I876_09495	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
I876_09500	ENOG4105E33	succinate dehydrogenase
I876_09505	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
I876_09510	ENOG4105C7S	Dehydrogenase
I876_09515	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
I876_09520	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
I876_09530	ENOG4105QV4	Tryptophan halogenase
I876_09535	ENOG4105QV4	Tryptophan halogenase
I876_09550	ENOG4108NRW	Phospholipase, patatin family
I876_09570	ENOG4108IUK	alpha amylase, catalytic
I876_09585	ENOG4105ETE	Transcriptional regulator (LacI family
I876_09590	ENOG4105CX6	glutaminyL-tRNA synthetase
I876_09595	ENOG4105UBK	short-chain dehydrogenase reductase
I876_09600	ENOG4108M0H	Extracellular lipase
I876_09605	ENOG4107SQI	penicillin amidase
I876_09610	ENOG4105ERU	peptidase
I876_09625	ENOG4107QNR	UPF0135 protein
I876_09630	ENOG4106371	Methyltransferase
I876_09635	ENOG4105C5I	Dehydrogenase
I876_09640	ENOG4108V06	Glutathione peroxidase
I876_09645	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
I876_09655	ENOG4105C1G	acyl-Coa dehydrogenase
I876_09660	ENOG4105E39	Enoyl-CoA hydratase
I876_09670	ENOG4105DHI	Methyltransferase
I876_09675	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
I876_09680	ENOG4105E68	Sulfatase
I876_09685	ENOG4105YDX	UPF0352 protein
I876_09690	ENOG4106V8H	Nucleoid-associated protein
I876_09720	ENOG4108HRK	Histidine kinase
I876_09725	ENOG4108VAC	response regulator
I876_09730	ENOG4105CTQ	phosphohexokinase
I876_09740	ENOG4105EKQ	RNA-directed DNA polymerase
I876_09805	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
I876_09830	ENOG4105D7V	transposase
I876_09875	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
I876_09925	ENOG4105CPQ	Dehydrogenase
I876_09935	ENOG4105EMU	Dehydrogenase
I876_09940	ENOG4105EJC	lysr family transcriptional regulator
I876_09950	ENOG4108KSB	HipA-like N-terminal domain
I876_09955	ENOG4105MHH	HipA N-terminal domain protein
I876_09980	ENOG4105F2I	Transposase
I876_09990	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
I876_10005	ENOG4105BZU	Histidine kinase
I876_10015	ENOG4105C72	UPF0176 protein
I876_10025	ENOG4105C1J	atp-dependent rna helicase
I876_10035	ENOG4105D6N	CoA-transferase, subunit a
I876_10040	ENOG4105F04	LysR family Transcriptional regulator
I876_10055	ENOG4107R11	Transcriptional regulator
I876_10060	ENOG4105EJQ	L-serine dehydratase
I876_10070	ENOG4105CRQ	synthase (Component I)
I876_10085	ENOG4105CGY	Dna recombination protein
I876_10090	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
I876_10100	ENOG4105CPP	Dehydrogenase, E1 component
I876_10110	ENOG4105D6S	protein involved in catabolism of external DNA
I876_10120	ENOG4105C29	acyl-CoA thioesterase
I876_10125	ENOG4108Z0R	Transferase
I876_10130	ENOG4105C5R	Aminotransferase
I876_10140	ENOG4108ZGC	gaf domain protein
I876_10150	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
I876_10155	ENOG4105CN1	protease
I876_10160	ENOG4105C8J	)-transporter
I876_10165	ENOG4105DFD	Na H antiporter
I876_10170	ENOG4105CD8	aminopeptidase N
I876_10190	ENOG4105D25	secreted protein
I876_10205	ENOG4105C7I	Dehydrogenase
I876_10210	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
I876_10215	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
I876_10225	ENOG4105C5H	ABC transporter
I876_10235	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
I876_10240	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
I876_10250	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
I876_10270	ENOG4105CAH	Chromate
I876_10285	ENOG4105BZU	Histidine kinase
I876_10290	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
I876_10300	ENOG4105BZU	Histidine kinase
I876_10305	ENOG4105BZU	Histidine kinase
I876_10335	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
I876_10340	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
I876_10355	ENOG4105F5W	AtP-binding protein
I876_10360	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
I876_10365	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
I876_10370	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
I876_10375	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
I876_10380	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
I876_10400	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
I876_10410	ENOG41080IJ	Diacylglycerol kinase
I876_10415	ENOG41081QV	Universal stress protein
I876_10425	ENOG4105CBC	glutamate synthase
I876_10430	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
I876_10435	ENOG4108UQY	Iron-storage protein
I876_10450	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
I876_10465	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
I876_10490	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
I876_10495	ENOG4105Q9Y	Universal stress protein
I876_10500	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
I876_10505	ENOG4105D78	K07001 NTE family protein
I876_10525	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
I876_10530	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
I876_10535	ENOG4105KHC	sulfurtransferase
I876_10540	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
I876_10545	ENOG4106IUH	DTW domain containing protein
I876_10625	ENOG4105DFP	Integrase
I876_10635	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
I876_10640	ENOG4105WH1	Two component transcriptional regulator luxr family
I876_10645	ENOG4105CHM	Aminotransferase
I876_10665	ENOG4108VGI	doxx family
I876_10670	ENOG4105CC0	LysR family Transcriptional regulator
I876_10685	ENOG4108MN8	Membrane
I876_10690	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
I876_10705	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
I876_10735	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
I876_10740	ENOG4105WMR	Protein CrcB homolog
I876_10745	ENOG4105D1H	recombination factor protein RarA
I876_10755	ENOG4105CNU	cell division protein FtsK
I876_10760	ENOG4105EW9	transcriptional regulator AsnC family
I876_10765	ENOG4105DCF	alanine dehydrogenase
I876_10770	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
I876_10775	ENOG4105CFV	Tetratricopeptide repeat protein
I876_10790	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
I876_10795	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
I876_10800	ENOG4105CAT	Cytidine monophosphate kinase
I876_10805	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
I876_10810	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
I876_10815	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
I876_10820	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
I876_10825	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
I876_10830	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
I876_10835	ENOG4105XPH	Ferredoxin
I876_10855	ENOG4105BZU	Histidine kinase
I876_10865	ENOG4105C8V	SAICAR synthetase
I876_10870	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
I876_10875	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
I876_10885	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I876_10895	ENOG4105ERG	peptidase m48, ste24p
I876_10905	ENOG4105K89	arsenate reductase
I876_10910	ENOG4105CS1	NAD(P)H quinone oxidoreductase
I876_10920	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
I876_10930	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
I876_10935	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
I876_10945	ENOG4107QPN	acyl-Coa dehydrogenase
I876_10960	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
I876_10965	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
I876_10970	ENOG4105DBI	uridine monophosphokinase
I876_10975	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
I876_10980	ENOG4105C3Q	Glycosyl transferase, family 2
I876_10985	ENOG4107QW3	Sucrose phosphorylase
I876_10990	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
I876_10995	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
I876_11000	ENOG4107QI1	Mate efflux family protein
I876_11020	ENOG4105C6T	cysteine synthase
I876_11060	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
I876_11105	ENOG4105JAB	phenazine biosynthesis protein, phzf family
I876_11110	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
I876_11115	ENOG41060WC	Enoyl-CoA hydratase
I876_11135	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
I876_11145	ENOG4105C28	cystathionine
I876_11160	ENOG4105CGF	Aromatic amino acid aminotransferase
I876_11180	ENOG4108UPT	UPF0178 protein
I876_11185	ENOG4105CHR	reductase
I876_11190	ENOG4105CHR	reductase
I876_11195	ENOG4105CSU	acyl-Coa dehydrogenase
I876_11200	ENOG4105FTV	AraC Family Transcriptional Regulator
I876_11230	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
I876_11240	ENOG4105C10	Electron transfer flavoprotein
I876_11245	ENOG4105BZJ	Electron transfer flavoprotein
I876_11250	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
I876_11255	ENOG4108YX2	DNA-binding protein
I876_11260	ENOG4105EV9	Alpha Beta Hydrolase
I876_11270	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
I876_11275	ENOG4108NVR	Methyl-accepting chemotaxis
I876_11280	ENOG41090R7	Ferric uptake
I876_11295	ENOG4105P4J	Allophanate hydrolase, subunit 1
I876_11300	ENOG4105E7W	lamb ycsf family protein
I876_11305	ENOG4105QNR	S1 RNA binding domain protein
I876_11310	ENOG4108UKZ	OsmC family
I876_11315	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
I876_11340	ENOG4105CHM	Aminotransferase
I876_11345	ENOG4105DK2	UPF0207 protein
I876_11350	ENOG4105DK2	UPF0207 protein
I876_11360	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
I876_11365	ENOG4108XHQ	(2Fe-2S)-binding domain protein
I876_11390	ENOG4105ENX	hydrolase
I876_11395	ENOG4105CF7	AraC family transcriptional regulator
I876_11405	ENOG4105DK2	UPF0207 protein
I876_11410	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
I876_11435	ENOG4105K5B	UPF0225 protein
I876_11445	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
I876_11455	ENOG4105C1G	acyl-Coa dehydrogenase
I876_11465	ENOG4107ZSV	Receptor
I876_11485	ENOG4105D4P	Coproporphyrinogen iii oxidase
I876_11490	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
I876_11495	ENOG4105E0C	molybdate abc transporter
I876_11505	ENOG4108ZAF	Molybdopterin
I876_11510	ENOG4105M00	molybdopterin converting factor, subunit 1
I876_11520	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
I876_11530	ENOG4105D06	uba thif-type nad fad binding protein
I876_11545	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
I876_11565	ENOG4105EG6	Saccharopine dehydrogenase
I876_11570	ENOG4105CIH	Imidazole acetol-phosphate transaminase
I876_11590	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
I876_11600	ENOG4107AQZ	Membrane
I876_11615	ENOG4107QYX	exodeoxyribonuclease v alpha
I876_11620	ENOG4107QKA	exodeoxyribonuclease V beta
I876_11625	ENOG4105DSY	exodeoxyribonuclease V, gamma
I876_11640	ENOG4108IQE	Amp-dependent synthetase and ligase
I876_11665	ENOG4105CVI	Transcriptional regulator
I876_11685	ENOG41082SX	arsR family transcriptional regulator
I876_11695	ENOG4105DUM	transcriptional regulator, lysR family
I876_11705	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_11750	ENOG4105DK2	UPF0207 protein
I876_11775	ENOG4105VUT	cytoplasmic protein
I876_11790	ENOG4105BZG	amino acid carrier protein
I876_11810	ENOG4105E0X	reductase
I876_11815	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
I876_11825	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
I876_11830	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
I876_11835	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
I876_11840	ENOG4105DSB	aldose 1-epimerase
I876_11845	ENOG4108UHU	Aldolase
I876_11850	ENOG4105CHC	glucokinase (EC 2.7.1.2)
I876_11855	ENOG4105C01	Dihydroxy-acid dehydratase
I876_11860	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
I876_11865	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
I876_11870	ENOG4106KNT	transcriptional regulator
I876_11875	ENOG4105CA9	Pyruvate kinase
I876_11880	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
I876_11900	ENOG4105K3G	Periplasmic Protein
I876_11930	ENOG4105EIG	urea carboxylase-associated protein 1
I876_11955	ENOG4105CHR	reductase
I876_11965	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
I876_11970	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
I876_11975	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
I876_11980	ENOG4105ETE	Transcriptional regulator (LacI family
I876_11985	ENOG4105CTX	dehydratase
I876_11990	ENOG4105D2H	Uronic isomerase
I876_11995	ENOG4105DEI	Mannitol dehydrogenase
I876_12000	ENOG4108UHU	Aldolase
I876_12005	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
I876_12010	ENOG4107TDE	lipolytic protein G-D-S-L family
I876_12020	ENOG4107XII	Glycosyl Hydrolase Family 88
I876_12030	ENOG4105NBR	Pectinesterase
I876_12035	ENOG4105BZU	Histidine kinase
I876_12050	ENOG4108K8S	endonuclease I
I876_12055	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_12070	ENOG4108W5M	transcriptional regulator
I876_12075	ENOG4108I6A	alcohol dehydrogenase
I876_12090	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_12095	ENOG4105BZU	Histidine kinase
I876_12105	ENOG4105C8P	)-transporter
I876_12110	ENOG4105DHP	deoxycytidine triphosphate deaminase
I876_12115	ENOG4105D1F	ATP-binding protein
I876_12120	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
I876_12130	ENOG4105D1A	Methyltransferase
I876_12135	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
I876_12140	ENOG4105E9H	Lytic Murein transglycosylase
I876_12165	ENOG4105C8N	cysteinyl-tRNA synthetase
I876_12170	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
I876_12180	ENOG4105G6Z	alkaline phosphatase
I876_12185	ENOG4105G6Z	alkaline phosphatase
I876_12200	ENOG4107S78	Band 7 protein
I876_12205	ENOG4105CBN	LysR family transcriptional regulator
I876_12225	ENOG4105KVH	Transcriptional regulator
I876_12240	ENOG4105CIS	alcohol dehydrogenase
I876_12260	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
I876_12270	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
I876_12275	ENOG4105E96	Colicin v production protein
I876_12280	ENOG4108S3P	Sporulation domain protein
I876_12285	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
I876_12290	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
I876_12320	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
I876_12325	ENOG4105MP9	class II Aldolase
I876_12340	ENOG4105YAJ	CopG Arc MetJ
I876_12345	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
I876_12350	ENOG4105CEY	Amp-dependent synthetase and ligase
I876_12360	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
I876_12395	ENOG4108Z6Z	Transcriptional regulator
I876_12400	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
I876_12415	ENOG4105DKW	ABC transporter
I876_12420	ENOG4105CRW	Short chain fatty acid transporter
I876_12425	ENOG4105BZU	Histidine kinase
I876_12450	ENOG4108BPE	-transporting atpase
I876_12475	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
I876_12510	ENOG4108UH6	UPF0754 membrane protein
I876_12535	ENOG4105CUG	Oligopeptidase b
I876_12540	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
I876_12545	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
I876_12550	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
I876_12555	ENOG4108428	Inherit from COG: -acetyltransferase
I876_12565	ENOG4108ZZ3	UPF0260 protein
I876_12570	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
I876_12580	ENOG4105VNG	YcgL domain-containing protein
I876_12585	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
I876_12590	ENOG4105CEY	Amp-dependent synthetase and ligase
I876_12595	ENOG410832A	alpha/beta hydrolase fold
I876_12610	ENOG41072GX	Peptidase M22 Glycoprotease
I876_12615	ENOG4105DVT	helicase
I876_12665	ENOG4105D05	Receptor
I876_12675	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
I876_12680	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
I876_12685	ENOG4105CIH	Imidazole acetol-phosphate transaminase
I876_12690	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
I876_12700	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
I876_12705	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
I876_12710	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
I876_12725	ENOG4105S64	Formate nitrite transporter
I876_12730	ENOG4107RAN	Peptidase, M16
I876_12735	ENOG4105C3F	Signal peptidase i
I876_12750	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
I876_12755	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
I876_12760	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
I876_12770	ENOG4105BZU	Histidine kinase
I876_12775	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
I876_12780	ENOG4107QMP	dna polymerase iii subunits gamma and tau
I876_12785	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
I876_12795	ENOG4105E18	UPF0276 protein
I876_12805	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
I876_12820	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
I876_12835	ENOG41068YB	TPR repeat-containing protein
I876_12840	ENOG4105CXG	d-lactate dehydrogenase
I876_12845	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
I876_12850	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
I876_12855	ENOG4105C34	Pseudouridine synthase
I876_12860	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_12870	ENOG4105K6V	RNA polymerase
I876_12885	ENOG4105EMU	Dehydrogenase
I876_12900	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
I876_12905	ENOG4106VK6	Flagellar motor protein
I876_12910	ENOG4105E14	MotA TolQ exbB proton channel
I876_12920	ENOG4105CTB	Polyprenyl synthetase
I876_12925	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
I876_12930	ENOG4108ZAI	phosphatidylglycerophosphatase a
I876_12935	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
I876_12940	ENOG4107YIM	Involved in the transcription termination process (By similarity)
I876_12945	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
I876_12960	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
I876_12965	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
I876_12970	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
I876_12975	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
I876_12980	ENOG4105C5H	ABC transporter
I876_12990	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
I876_13000	ENOG4105EAC	phosphoserine phosphatase
I876_13010	ENOG4105EYA	deoxyribonuclease
I876_13015	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
I876_13020	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
I876_13025	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
I876_13030	ENOG4105C3F	Signal peptidase i
I876_13035	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
I876_13055	ENOG4105EMN	RNA polymerase sigma factor
I876_13065	ENOG4108IYU	L-aspartate oxidase
I876_13080	ENOG4105Y75	tpr repeat protein
I876_13085	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
I876_13090	ENOG4108YZY	peptidylprolyl cis-trans isomerase
I876_13095	ENOG4108YZA	Nitrogen regulatory protein pii
I876_13100	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
I876_13160	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
I876_13165	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
I876_13170	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
I876_13175	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
I876_13180	ENOG4105DTN	riboflavin biosynthesis protein ribF
I876_13185	ENOG4105CJR	Integral membrane protein (MviN
I876_13190	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
I876_13210	ENOG4105C09	Bile acid
I876_13230	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
I876_13240	ENOG4105EIN	peptidylprolyl cis-trans isomerase
I876_13245	ENOG4105K70	DNA-binding protein
I876_13250	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
I876_13255	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
I876_13260	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
I876_13265	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
I876_13270	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
I876_13280	ENOG4108R96	Methyltransferase, YaeB family
I876_13285	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
I876_13290	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
I876_13295	ENOG4105HDD	phospholipase
I876_13300	ENOG4105DGU	Histone deacetylase
I876_13305	ENOG4108NVR	Methyl-accepting chemotaxis
I876_13320	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
I876_13325	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
I876_13330	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
I876_13345	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
I876_13350	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
I876_13355	ENOG4105N21	Membrane
I876_13360	ENOG4105CUT	histidyl-tRNA synthetase
I876_13365	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
I876_13380	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
I876_13385	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
I876_13390	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
I876_13400	ENOG4108Z4V	iron-sulfur cluster assembly
I876_13410	ENOG4105JRK	feS assembly protein SufD
I876_13415	ENOG4105C3K	feS assembly ATPase SufC
I876_13425	ENOG4105C3J	Cysteine desulfurase
I876_13430	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
I876_13435	ENOG4105CT3	Monooxygenase
I876_13440	ENOG4105D7W	serine acetyltransferase
I876_13445	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
I876_13465	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
I876_13470	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
I876_13475	ENOG4105VIE	preprotein translocase, subunit YajC
I876_13480	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
I876_13485	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
I876_13500	ENOG4108P9J	Phage shock protein A
I876_13525	ENOG4106032	Glutathionylspermidine synthase
I876_13540	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
I876_13555	ENOG4105CSV	Glutaminase
I876_13560	ENOG4105G6Z	alkaline phosphatase
I876_13570	ENOG4107RET	Isocitrate lyase
I876_13625	ENOG4105C0H	protease
I876_13650	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
I876_13670	ENOG4105CPK	Glycosyl transferase (Group 1
I876_13685	ENOG4105CAQ	asparagine synthetase
I876_13690	ENOG4105CPK	Glycosyl transferase (Group 1
I876_13710	ENOG4105MME	Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family
I876_13765	ENOG4105D3Q	Sugar transferase
I876_13780	ENOG4108QV3	biosynthesis protein
I876_13795	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
I876_13815	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
I876_13825	ENOG4105D1S	lipid A biosynthesis
I876_13840	ENOG4107QPN	acyl-Coa dehydrogenase
I876_13855	ENOG4105BZU	Histidine kinase
I876_13860	ENOG4107104	thymidine kinase
I876_13875	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
I876_13915	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
I876_13920	ENOG4108RWN	rrna methyltransferase
I876_13925	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
I876_13940	ENOG4105C26	Dehydrogenase
I876_13945	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
I876_13960	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
I876_13965	ENOG4108Z4X	TRANSCRIPTIONal
I876_13995	ENOG4105CSU	acyl-Coa dehydrogenase
I876_14025	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
I876_14030	ENOG4105E0F	Histidine kinase
I876_14040	ENOG4105NA0	Transcriptional regulator
I876_14060	ENOG4107XDR	Lactoylglutathione lyase
I876_14070	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
I876_14075	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
I876_14080	ENOG4105C7W	Xanthine dehydrogenase
I876_14100	ENOG4105CHR	reductase
I876_14105	ENOG4105EMU	Dehydrogenase
I876_14110	ENOG4107RKG	DJ-1/PfpI family
I876_14115	ENOG4107U9T	Pfam:Ribonuclease_BN
I876_14125	ENOG4108VWS	Yaeq family
I876_14155	ENOG4105S8Q	sugar efflux transporter
I876_14170	ENOG4105C9U	ATP-dependent DNA helicase RecQ
I876_14190	ENOG4105BZU	Histidine kinase
I876_14200	ENOG4105BZU	Histidine kinase
I876_14210	ENOG4105D8V	Glucose sorbosone dehydrogenase
I876_14220	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
I876_14225	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
I876_14230	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
I876_14235	ENOG4105CQM	Urea amidohydrolase subunit alpha
I876_14240	ENOG4105KI2	Urea amidohydrolase subunit beta
I876_14245	ENOG4108YZ9	Urea amidohydrolase subunit gamma
I876_14250	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
I876_14255	ENOG4108IV0	ABC, transporter
I876_14260	ENOG4105C0Z	ABC transporter
I876_14270	ENOG4105C32	Amino acid ABC transporter (Permease)
I876_14285	ENOG4105BZU	Histidine kinase
I876_14290	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
I876_14295	ENOG4105F5W	AtP-binding protein
I876_14345	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
I876_14360	ENOG4106H31	ATP-dependent protease ATP-binding subunit-like protein
I876_14445	ENOG4105GAV	receptor
I876_14470	ENOG4105PGM	cation diffusion facilitator family transporter
I876_14480	ENOG4105PGM	cation diffusion facilitator family transporter
I876_14490	ENOG4105E5H	Transposase
I876_14515	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
I876_14520	ENOG4105E66	phosphoriboisomerase A
I876_14525	ENOG4108JQ1	Dehydrogenase
I876_14545	ENOG4105XZD	Fe-S protein
I876_14575	ENOG4107QN2	dihydrolipoyl dehydrogenase
I876_14580	ENOG4107QSN	dihydrolipoamide acetyltransferase
I876_14585	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
I876_14590	ENOG41073TP	transcriptional regulator
I876_14600	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
I876_14605	ENOG4108WIW	Aspartyl protease
I876_14610	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
I876_14615	ENOG4108ZUW	Major pilin subunit
I876_14620	ENOG4105D7Q	type ii secretion system
I876_14635	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
I876_14640	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
I876_14645	ENOG4108Q6X	Aspartoacylase (EC 3.5.1.15)
I876_14650	ENOG4105M6F	mutator MutT protein
I876_14655	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
I876_14660	ENOG4105DR5	peptidase
I876_14665	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
I876_14670	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
I876_14675	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
I876_14680	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
I876_14685	ENOG4105CPF	Cell wall formation (By similarity)
I876_14690	ENOG4105DFU	Cell wall formation (By similarity)
I876_14695	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
I876_14700	ENOG4105CNI	cell division protein FtsW
I876_14705	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
I876_14710	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
I876_14715	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
I876_14720	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
I876_14725	ENOG4105CJN	penicillin-binding protein
I876_14730	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
I876_14735	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
I876_14740	ENOG4108V6E	Cell division protein mraZ
I876_14765	ENOG4108IJF	Heavy metal efflux pump, CzcA
I876_14790	ENOG4105EHV	domain protein
I876_14805	ENOG4105BZU	Histidine kinase
I876_14815	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_14820	ENOG4105BZU	Histidine kinase
I876_14855	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
I876_14860	ENOG4105D7Z	glutathione synthase
I876_14865	ENOG4108UJU	UPF0301 protein
I876_14870	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
I876_14880	ENOG4105CZX	twitching motility protein
I876_14885	ENOG4105CZX	twitching motility protein
I876_14890	ENOG4105DFA	alanine racemase domain protein
I876_14895	ENOG4105II7	pyrroline-5-carboxylate reductase
I876_14900	ENOG4108VIA	integral membrane protein
I876_14910	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
I876_14925	ENOG4108SHQ	Glutathione S-transferase
I876_14930	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
I876_14935	ENOG4108Z9K	Osmotically inducible protein
I876_14940	ENOG4107R50	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
I876_14955	ENOG4108UMN	azlc family
I876_14965	ENOG4105F27	Major Facilitator
I876_14970	ENOG4105VFU	Rna-binding protein
I876_14975	ENOG4105D1Q	UPF0246 protein
I876_14985	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
I876_14990	ENOG4107QP8	phosphohexose isomerase
I876_15000	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
I876_15005	ENOG4105D98	threonine synthase
I876_15010	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
I876_15025	ENOG4105CC0	LysR family Transcriptional regulator
I876_15040	ENOG41082YX	Transcriptional regulator, arsr family
I876_15050	ENOG4105CAU	Arsenical resistance protein, ArsH
I876_15055	ENOG4105D6J	arsenicaL-resistance protein
I876_15060	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
I876_15065	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
I876_15095	ENOG4105K6H	D-cysteine desulfhydrase
I876_15125	ENOG4105E3Q	saccharopine dehydrogenase
I876_15140	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
I876_15145	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
I876_15150	ENOG41082RQ	UPF0102 protein
I876_15160	ENOG4105CPK	Glycosyl transferase (Group 1
I876_15165	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
I876_15170	ENOG4105W4M	Transport-associated protein
I876_15190	ENOG4105BZU	Histidine kinase
I876_15220	ENOG4105CR4	methylisocitrate lyase
I876_15225	ENOG4105BZN	citrate synthase
I876_15230	ENOG4108I0Z	Aconitate hydratase
I876_15235	ENOG4105C7F	AcnD-accessory protein PrpF
I876_15240	ENOG4105BZU	Histidine kinase
I876_15285	ENOG4105BZU	Histidine kinase
I876_15290	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
I876_15295	ENOG4105CBC	glutamate synthase
I876_15300	ENOG4105BZ8	glutamate synthase
I876_15315	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
I876_15320	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
I876_15325	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
I876_15330	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
I876_15345	ENOG4105CJP	fad dependent oxidoreductase
I876_15350	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
I876_15360	ENOG4108K5P	(LipO)protein
I876_15365	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
I876_15370	ENOG4105EDR	glucose galactose transporter
I876_15380	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
I876_15400	ENOG4107MKT	Stringent starvation protein a
I876_15405	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
I876_15415	ENOG4105CSR	polyphosphate kinase 2
I876_15420	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
I876_15425	ENOG4107QMS	site-determining protein
I876_15430	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
I876_15435	ENOG4105C9Q	fumarate hydratase class II
I876_15470	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
I876_15475	ENOG4105CHM	Aminotransferase
I876_15485	ENOG4105CI3	gtp-binding protein typa
I876_15495	ENOG4105C5F	glutamine synthetase
I876_15505	ENOG4105CUX	Signal transduction histidine kinase
I876_15510	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_15515	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_15520	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
I876_15525	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
I876_15535	ENOG4105BZU	Histidine kinase
I876_15555	ENOG4105BZU	Histidine kinase
I876_15560	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
I876_15565	ENOG4105MYG	DNA polymerase iii, chi subunit
I876_15570	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
I876_15575	ENOG4108M8S	permease YjgP YjgQ family protein
I876_15580	ENOG4108K5H	permease YjgP YjgQ family protein
I876_15595	ENOG4105K6V	RNA polymerase
I876_15670	ENOG4105CNT	hydrolase family 2
I876_15680	ENOG4105CXK	mandelate racemase muconate lactonizing
I876_15685	ENOG4105D0H	Alpha-glucuronidase (EC 3.2.1.139)
I876_15700	ENOG410620I	Diguanylate cyclase
I876_15730	ENOG4105BZU	Histidine kinase
I876_15750	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
I876_15755	ENOG4105EHG	Permease protein
I876_15760	ENOG4107R4I	Periplasmic binding protein
I876_15770	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
I876_15780	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
I876_15785	ENOG4105EMK	carboxylate amino acid amine transporter
I876_15805	ENOG4107RF2	cellulose-binding family II protein
I876_15815	ENOG4105CY0	Metallo-Beta-Lactamase
I876_15835	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
I876_15870	ENOG4105DZG	Dehydrogenase
I876_15890	ENOG4105CJ1	ABC, transporter
I876_15900	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
I876_15905	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
I876_15910	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
I876_15915	ENOG4105WF7	pyrroloquinoline quinone biosynthesis protein d
I876_15920	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
I876_15950	ENOG4105BZU	Histidine kinase
I876_15970	ENOG4105WH1	Two component transcriptional regulator luxr family
I876_15975	ENOG4105BZU	Histidine kinase
I876_15980	ENOG4107SDU	Methyl-accepting chemotaxis
I876_15990	ENOG4105C26	Dehydrogenase
I876_15995	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
I876_16000	ENOG4105C94	Transporter
I876_16015	ENOG4107ZSV	Receptor
I876_16025	ENOG4105CC0	LysR family Transcriptional regulator
I876_16030	ENOG4105DMF	Dehydrogenase
I876_16035	ENOG4105CXG	d-lactate dehydrogenase
I876_16040	ENOG41086KC	Transcriptional regulator
I876_16045	ENOG4105P8Q	Curli production assembly transport component CsgG
I876_16075	ENOG4105WH1	Two component transcriptional regulator luxr family
I876_16085	ENOG4105DTD	Dehydrogenase
I876_16100	ENOG4105C1J	atp-dependent rna helicase
I876_16125	ENOG4108UHU	Aldolase
I876_16130	ENOG4108RVA	ribokinase
I876_16135	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
I876_16150	ENOG4105EGS	Mechanosensitive ion channel
I876_16160	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
I876_16170	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_16195	ENOG4105HF0	Membrane
I876_16200	ENOG4105CIH	Imidazole acetol-phosphate transaminase
I876_16215	ENOG4105BZU	Histidine kinase
I876_16225	ENOG4105CQ2	DNA polymerase
I876_16235	ENOG4105CEY	Amp-dependent synthetase and ligase
I876_16250	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
I876_16255	ENOG4105EJ2	Transcriptional regulator
I876_16265	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
I876_16275	ENOG4108RG0	uracil-dna glycosylase
I876_16280	ENOG4105BZU	Histidine kinase
I876_16290	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
I876_16295	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
I876_16320	ENOG4105FM1	phage shock protein C
I876_16325	ENOG41087YS	Phage shock protein A
I876_16335	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
I876_16370	ENOG4105UYK	outer membrane protein a
I876_16375	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
I876_16380	ENOG4105BZU	Histidine kinase
I876_16385	ENOG4105C4W	S-formylglutathione hydrolase
I876_16390	ENOG4106HNH	Acyl-transferase
I876_16395	ENOG4106HNH	Acyl-transferase
I876_16400	ENOG4105CUY	Mechanosensitive ion channel
I876_16415	ENOG4108535	NAD dependent epimerase/dehydratase family
I876_16420	ENOG4105C8J	)-transporter
I876_16435	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
I876_16450	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
I876_16460	ENOG4109015	Biopolymer transport protein exbD tolR
I876_16480	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
I876_16495	ENOG4107QZ7	Cellulose synthase catalytic subunit
I876_16505	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
I876_16510	ENOG4105K4T	epimerase
I876_16520	ENOG4105KWG	Pfam:DUF1696
I876_16525	ENOG4105BZU	Histidine kinase
I876_16535	ENOG4105EFZ	amidohydrolase
I876_16545	ENOG4105C5X	domain protein
I876_16555	ENOG4108WAV	Transcriptional regulator
I876_16560	ENOG4105E7A	Glutamine amidotransferase
I876_16570	ENOG4108Z12	YiaAB two helix domain-containing protein
I876_16590	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
I876_16600	ENOG4105C26	Dehydrogenase
I876_16605	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
I876_16610	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
I876_16615	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
I876_16625	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
I876_16630	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
I876_16635	ENOG4108R86	Transcriptional regulator
I876_16650	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
I876_16655	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
I876_16665	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
I876_16685	ENOG4105CJ2	(LipO)protein
I876_16690	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
I876_16695	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
I876_16700	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
I876_16705	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
I876_16710	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
I876_16715	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
I876_16720	ENOG4105RKW	reductase (By
I876_16725	ENOG4108V1T	peptidylprolyl cis-trans isomerase
I876_16730	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
I876_16745	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
I876_16750	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
I876_16760	ENOG4108KPZ	tonB-dependent Receptor
I876_16775	ENOG4105DBI	uridine monophosphokinase
I876_16780	ENOG4105D9N	nucleoside
I876_16800	ENOG4105BZU	Histidine kinase
I876_16805	ENOG4107S1V	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
I876_16815	ENOG4107QN1	sodium solute
I876_16835	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
I876_16845	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
I876_16860	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
I876_16875	ENOG4105CPC	Aldo Keto reductase
I876_16895	ENOG4105BZU	Histidine kinase
I876_16900	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
I876_16905	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
I876_16910	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
I876_16915	ENOG4105D4A	Cell wall formation (By similarity)
I876_16945	ENOG4108JJA	ABC, transporter
I876_16950	ENOG41063Z6	transcriptional regulator, lysR family
I876_16980	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
I876_16985	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
I876_16990	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
I876_16995	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
I876_17000	ENOG4107RDJ	Sulfotransferase
I876_17065	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
I876_17195	ENOG41084HI	prevent-host-death family
I876_17200	ENOG4108ZT0	50S ribosomal protein l17
I876_17205	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
I876_17210	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
I876_17215	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
I876_17220	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I876_17225	ENOG41067V7	50S ribosomal protein L36
I876_17230	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
I876_17235	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
I876_17240	ENOG4105VPB	50S ribosomal protein L30
I876_17245	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
I876_17250	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
I876_17255	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
I876_17260	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
I876_17265	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
I876_17270	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I876_17275	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
I876_17280	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
I876_17285	ENOG4105BZU	Histidine kinase
I876_17295	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
I876_17305	ENOG4105C2N	RNA methyltransferase TrmH family group 3
I876_17310	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
I876_17355	ENOG4108UV7	flagellar protein motX
I876_17365	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
I876_17370	ENOG4107QK7	reductase
I876_17385	ENOG4107VAM	peptidase, m28
I876_17395	ENOG4105BZU	Histidine kinase
I876_17405	ENOG4105C4M	(Ubiquinol oxidase) subunit I
I876_17410	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
I876_17420	ENOG4108XM1	transcriptional regulator AsnC family
I876_17430	ENOG4105VEQ	Cold shock protein
I876_17435	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
I876_17455	ENOG4105DGW	oligopeptidase A
I876_17460	ENOG4107YTP	response regulator receiver protein
I876_17470	ENOG4105BZU	Histidine kinase
I876_17475	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_17480	ENOG4105DC8	reductase
I876_17485	ENOG4107QY8	reductase
I876_17490	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
I876_17540	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
I876_17545	ENOG4108JJA	ABC, transporter
I876_17550	ENOG4105WH1	Two component transcriptional regulator luxr family
I876_17560	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
I876_17570	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
I876_17575	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
I876_17580	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
I876_17585	ENOG41063M6	Cell Division Protein
I876_17590	ENOG4105C25	Primosomal protein n'
I876_17595	ENOG4105VFB	Binds the 23S rRNA (By similarity)
I876_17605	ENOG4105C6K	Malic enzyme
I876_17610	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
I876_17615	ENOG4105SYT	Methylenetetrahydrofolate reductase
I876_17620	ENOG4107S2Z	UPF0761 membrane protein
I876_17640	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
I876_17645	ENOG4105SUU	thioesterase domain
I876_17650	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
I876_17655	ENOG4105D58	Diguanylate phosphodiesterase
I876_17660	ENOG4105D58	Diguanylate phosphodiesterase
I876_17665	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
I876_17670	ENOG4105CAK	Cell division ATP-binding protein ftsE
I876_17675	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
I876_17680	ENOG4106H78	methyltransferase
I876_17690	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
I876_17705	ENOG4105PW4	Sugar fermentation stimulation protein homolog
I876_17710	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I876_17715	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
I876_17720	ENOG4105DJ0	Poly(A) Polymerase
I876_17725	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I876_17730	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
I876_17735	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
I876_17740	ENOG4105DY8	decarboxylase
I876_17755	ENOG4105E3A	(ABC) transporter
I876_17760	ENOG4105DA5	(ABC) transporter
I876_17765	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
I876_17770	ENOG4105EB3	Histidine kinase
I876_17775	ENOG4108ESX	Receptor
I876_17780	ENOG4107E2E	PKHD-type hydroxylase
I876_17805	ENOG4105D22	carbon starvation protein
I876_17830	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
I876_17835	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
I876_17840	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
I876_17845	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
I876_17850	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
I876_17855	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
I876_17865	ENOG4108VZM	50s ribosomal protein L10
I876_17870	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
I876_17875	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
I876_17895	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
I876_17900	ENOG4105PM1	preprotein translocase subunit SecE
I876_17905	ENOG4105BZ1	(ABC) transporter
I876_17910	ENOG4105JSC	dimethylmenaquinone methyltransferase
I876_17915	ENOG4105C9K	Endothelin-converting enzyme 1
I876_17925	ENOG4105C1J	atp-dependent rna helicase
I876_17930	ENOG4105EKE	dihydroorotase
I876_17935	ENOG4105QNF	Outer membrane lipoprotein
I876_17940	ENOG4107RGM	aldo keto reductase
I876_17945	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
I876_17955	ENOG4105DP8	Major facilitator superfamily MFS_1
I876_17960	ENOG4107QW3	Sucrose phosphorylase
I876_17970	ENOG4105EUJ	GTP cyclohydrolase i
I876_17975	ENOG410642E	Short chain dehydrogenase
I876_17980	ENOG4105DWY	Agmatine deiminase
I876_17995	ENOG4107QRT	dEAD DEAH box helicase
I876_18005	ENOG4107T0X	DNA ligase
I876_18010	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
I876_18015	ENOG4105D7K	pfkb domain protein
I876_18030	ENOG4105CYM	Glutathione S-transferase
I876_18045	ENOG4107IFA	Lipase (EC 3.1.1.3)
I876_18050	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
I876_18075	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
I876_18080	ENOG4105CFC	Transporter
I876_18085	ENOG4105EPW	hflc protein
I876_18090	ENOG4107QJR	hflk protein
I876_18095	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
I876_18100	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
I876_18105	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
I876_18110	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
I876_18115	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
I876_18120	ENOG4105K8N	protein family UPF0079, ATPase
I876_18125	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
I876_18130	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
I876_18140	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
I876_18150	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
I876_18155	ENOG4105MYN	Zinc uptake regulation protein
I876_18165	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
I876_18170	ENOG4105CDV	Ompa motb domain protein
I876_18175	ENOG4105CDU	Replicative dna helicase
I876_18200	ENOG4108RPX	mosc domain containing protein
I876_18215	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
I876_18220	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
I876_18225	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
I876_18230	ENOG4105BZU	Histidine kinase
I876_18240	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
I876_18250	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
I876_18255	ENOG4105BZU	Histidine kinase
I876_18260	ENOG4105C8Q	Methyl-accepting chemotaxis
I876_18270	ENOG4105PGM	cation diffusion facilitator family transporter
I876_18285	ENOG4105DFD	Na H antiporter
I876_18305	ENOG41060NJ	transcriptional regulator
I876_18310	ENOG4107QNK	)-transporter
I876_18315	ENOG4108JJ8	(ABC) transporter
I876_18320	ENOG4108JJ9	ABC, transporter
I876_18330	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
I876_18335	ENOG4105C4M	(Ubiquinol oxidase) subunit I
I876_18345	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
I876_18370	ENOG4108VSZ	Inherit from COG: ketosteroid isomerase-like protein
I876_18380	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
I876_18390	ENOG4105Q26	Siderophore-interacting protein
I876_18395	ENOG4105VDW	Csbd family
I876_18415	ENOG4108YZN	class I peptide chain release factor
I876_18420	ENOG4107TTQ	Alpha beta hydrolase fold
I876_18440	ENOG4105DS1	cytochrome b561
I876_18450	ENOG4105CEP	NADH dehydrogenase
I876_18465	ENOG4105CR8	Transcriptional regulator
I876_18470	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
I876_18475	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
I876_18485	ENOG4105BZU	Histidine kinase
I876_18500	ENOG4105DEN	Luciferase family
I876_18505	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
I876_18510	ENOG4105E98	transcriptional regulator DeoR family
I876_18515	ENOG4105D9R	oxidoreductase
I876_18520	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
I876_18530	ENOG4108Q5Y	Membrane
I876_18535	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
I876_18540	ENOG4105D03	DNA-3-methyladenine glycosylase II
I876_18545	ENOG41066YJ	Beta-lactamase
I876_18550	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
I876_18560	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
I876_18565	ENOG4105W8H	transhydrogenase (subunit alpha
I876_18570	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
I876_18615	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
I876_18620	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
I876_18625	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
I876_18630	ENOG4105CCU	oxidase (Subunit III)
I876_18635	ENOG4105BZ9	Cytochrome C oxidase, subunit I
I876_18640	ENOG4105E2S	oxidase) subunit II
I876_18675	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
I876_18680	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
I876_18685	ENOG4105FS0	cytoplasmic membrane protein
I876_18690	ENOG4105VF7	tolerance protein
I876_18695	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
I876_18700	ENOG4105DR5	peptidase
I876_18705	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
I876_18710	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
I876_18715	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
I876_18760	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
I876_18770	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
I876_18775	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
I876_18780	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
I876_18785	ENOG4105DC1	bifunctional purine biosynthesis protein purh
I876_18795	ENOG4105C12	Phosphoribosylglycinamide synthetase
I876_18810	ENOG4105EYW	Ion transport protein
I876_18815	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
I876_18825	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
I876_18835	ENOG4105E0F	Histidine kinase
I876_18845	ENOG4105CJQ	hydrolase, family 31
I876_18850	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
I876_18855	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
I876_18860	ENOG4105VEJ	Heat shock protein
I876_18865	ENOG4108XKW	General secretion pathway protein C
I876_18875	ENOG4107QHF	type ii secretion system protein e
I876_18880	ENOG4105D7Q	type ii secretion system
I876_18885	ENOG4108VAU	general secretion pathway protein G
I876_18890	ENOG4105VWV	general secretion pathway protein h
I876_18930	ENOG4105C26	Dehydrogenase
I876_18940	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
I876_18945	ENOG4107RK2	ADP-ribose diphosphatase NudE
I876_18960	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
I876_18965	ENOG4105DJ9	glucan biosynthesis protein
I876_18975	ENOG4105YP7	UPF0270 protein
I876_18980	ENOG4105DNZ	Alpha Beta Hydrolase
I876_18990	ENOG4105C5H	ABC transporter
I876_19010	ENOG41069P5	Protein slyX homolog
I876_19020	ENOG4108V1T	peptidylprolyl cis-trans isomerase
I876_19030	ENOG4108RRZ	Transcription elongation factor GreB
I876_19035	ENOG4105BZM	domain protein
I876_19055	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
I876_19060	ENOG4105MJ2	Competence protein
I876_19070	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
I876_19090	ENOG4107R73	Mate efflux family protein
I876_19105	ENOG4108ZX6	Electron transport protein SCO1 SenC
I876_19110	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
I876_19115	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
I876_19135	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
I876_19140	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
I876_19145	ENOG4105BZ9	Cytochrome C oxidase, subunit I
I876_19155	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
I876_19160	ENOG4105BZU	Histidine kinase
I876_19165	ENOG4105E55	glycerol-3-phosphate acyltransferase
I876_19170	ENOG4105C7B	Threonine dehydratase
I876_19175	ENOG4105C01	Dihydroxy-acid dehydratase
I876_19180	ENOG4105EN6	Membrane
I876_19185	ENOG4105C0P	Mg chelatase subunit ChlI
I876_19190	ENOG4105EMY	transcriptional regulator
I876_19195	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
I876_19200	ENOG4105C2C	drug resistance transporter, Bcr CflA
I876_19210	ENOG4105CFU	surface antigen
I876_19215	ENOG4105MA0	exported protein
I876_19240	ENOG4105C5I	Dehydrogenase
I876_19250	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
I876_19290	ENOG4105CI2	imidazolone-5-propionate hydrolase
I876_19315	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
I876_19320	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
I876_19325	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
I876_19335	ENOG4105DSJ	YicC domain protein
I876_19405	ENOG4105DZR	Type I site-specific deoxyribonuclease
I876_19450	ENOG4107R3N	Filamentation induced by cAMP protein fic
I876_19460	ENOG41060NJ	transcriptional regulator
I876_19470	ENOG4105CDV	Ompa motb domain protein
I876_19475	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
I876_19490	ENOG4108K3A	Glutathione S-transferase
I876_19505	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
I876_19510	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
I876_19515	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
I876_19520	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
I876_19525	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
I876_19530	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
I876_19535	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
I876_19540	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
I876_19550	ENOG4105FA0	parb-like partition protein
I876_19555	ENOG4107QJE	Chromosome Partitioning Protein
I876_19560	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
I876_19565	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
I876_19580	ENOG4105QTB	Flavodoxin
I876_19590	ENOG4108VPT	UPF0234 protein
I876_19595	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
I876_19600	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
I876_19605	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
I876_19610	ENOG4105VG0	50S ribosomal protein l34