locus-tag	class	description
I876_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I876_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I876_00025	COG0187	DNA topoisomerase II activity
I876_00045	COG2818	Glycosylase
I876_00055	COG3078	GTPase activator activity
I876_00075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I876_00075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I876_00080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I876_00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I876_00090	COG0569	domain protein
I876_00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I876_00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I876_00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I876_00115	COG0758	DNA mediated transformation
I876_00130	COG0009	L-threonylcarbamoyladenylate synthase
I876_00135	COG0408	coproporphyrinogen oxidase activity
I876_00140	COG3047	cAMP biosynthetic process
I876_00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I876_00220	COG2234	aminopeptidase activity
I876_00225	COG0463	Glycosyl transferase, family 2
I876_00235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I876_00260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_00290	COG3642	lipopolysaccharide core region biosynthetic process
I876_00295	COG0859	PFAM glycosyl transferase family 9
I876_00325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_00340	COG3161	chorismate lyase activity
I876_00345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I876_00365	COG0210	DNA helicase
I876_00410	COG1959	2 iron, 2 sulfur cluster binding
I876_00415	COG0730	response to heat
I876_00430	COG4771	TonB-dependent receptor
I876_00445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I876_00450	COG4988	ABC transporter
I876_00460	COG1271	oxidase subunit
I876_00470	COG0425	Belongs to the sulfur carrier protein TusA family
I876_00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_00480	COG0450	alkyl hydroperoxide reductase
I876_00490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I876_00520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_00555	COG1129	ABC transporter
I876_00555	COG0842	Transport permease protein
I876_00560	COG0842	Transport permease protein
I876_00575	COG1960	acyl-CoA dehydrogenase activity
I876_00580	COG0583	DNA-binding transcription factor activity
I876_00590	COG3106	COG3106 Predicted ATPase
I876_00610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I876_00630	COG0352	thiamine-phosphate diphosphorylase activity
I876_00640	COG3071	HemY protein
I876_00645	COG2959	enzyme of heme biosynthesis
I876_00655	COG0181	hydroxymethylbilane synthase activity
I876_00675	COG0194	GDP metabolic process
I876_00685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I876_00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I876_00700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I876_00710	COG0678	peroxiredoxin activity
I876_00725	COG1178	ABC-type Fe3 transport system permease component
I876_00730	COG3842	ATPase activity
I876_00735	COG0668	transmembrane transport
I876_00740	COG2081	HI0933 family
I876_00755	COG2963	transposase activity
I876_00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_00790	COG0427	acetyl-CoA hydrolase
I876_00795	COG0123	including yeast histone deacetylase and acetoin utilization protein
I876_00810	COG0840	transmembrane signaling receptor activity
I876_00820	COG3064	Membrane
I876_00830	COG5001	Diguanylate cyclase
I876_00830	COG5002	protein histidine kinase activity
I876_00845	COG0514	ATP-dependent DNA helicase (RecQ)
I876_00850	COG2239	Acts as a magnesium transporter
I876_00855	COG2962	Rard protein
I876_00860	COG3706	GGDEF domain
I876_00860	COG0745	RESPONSE REGULATOR receiver
I876_00865	COG0210	DNA helicase
I876_00875	COG1011	Hydrolase
I876_00890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I876_00895	COG0019	diaminopimelate decarboxylase activity
I876_00940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I876_00940	COG2755	lipolytic protein G-D-S-L family
I876_00950	COG0163	prenyltransferase activity
I876_00955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I876_00970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I876_00990	COG1077	Cell shape determining protein MreB Mrl
I876_01000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I876_01015	COG1085	galactose-1-phosphate uridylyltransferase
I876_01020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I876_01030	COG0629	single-stranded DNA binding
I876_01045	COG3250	beta-galactosidase activity
I876_01070	COG1349	DNA-binding transcription factor activity
I876_01115	COG3409	Peptidoglycan-binding domain 1 protein
I876_01115	COG3267	Type II secretory pathway component ExeA
I876_01130	COG1459	type II secretion system
I876_01175	COG1077	Cell shape determining protein MreB Mrl
I876_01180	COG1792	Involved in formation and maintenance of cell shape
I876_01185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I876_01195	COG1530	ribonuclease E activity
I876_01205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_01210	COG0312	modulator of DNA gyrase
I876_01215	COG3028	Belongs to the UPF0307 family
I876_01220	COG0312	modulator of DNA gyrase
I876_01235	COG0745	RESPONSE REGULATOR receiver
I876_01240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_01240	COG4191	Histidine kinase
I876_01245	COG0297	glycogen (starch) synthase activity
I876_01255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I876_01260	COG0596	Alpha beta hydrolase
I876_01275	COG2865	translation initiation factor activity
I876_01355	COG5310	Homospermidine synthase
I876_01380	COG3251	PFAM MbtH domain protein
I876_01540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I876_01550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I876_01560	COG0463	Glycosyl transferase, family 2
I876_01565	COG0745	RESPONSE REGULATOR receiver
I876_01570	COG5002	protein histidine kinase activity
I876_01625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I876_01630	COG5002	protein histidine kinase activity
I876_01635	COG0745	RESPONSE REGULATOR receiver
I876_01660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_01760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I876_01790	COG0375	protein maturation
I876_01800	COG0409	Hydrogenase expression formation protein
I876_01810	COG0309	Hydrogenase expression formation protein (HypE)
I876_01815	COG0789	Transcriptional regulator
I876_01820	COG2217	Heavy metal translocating P-type atpase
I876_01915	COG0531	amino acid
I876_01925	COG2132	Multicopper oxidase
I876_01955	COG0745	RESPONSE REGULATOR receiver
I876_01965	COG0835	chemotaxis
I876_01980	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I876_01995	COG0745	RESPONSE REGULATOR receiver
I876_02005	COG0835	chemotaxis
I876_02025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I876_02055	COG0546	phosphoglycolate phosphatase activity
I876_02080	COG1609	Transcriptional regulator
I876_02085	COG0673	inositol 2-dehydrogenase activity
I876_02095	COG2211	Major facilitator Superfamily
I876_02120	COG1454	alcohol dehydrogenase
I876_02170	COG0089	rRNA binding
I876_02180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I876_02190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I876_02205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I876_02210	COG0438	transferase activity, transferring glycosyl groups
I876_02220	COG1519	Transferase
I876_02240	COG0840	transmembrane signaling receptor activity
I876_02255	COG0788	formyltetrahydrofolate deformylase activity
I876_02265	COG1643	Atp-dependent helicase
I876_02270	COG2951	lytic endotransglycosylase activity
I876_02275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I876_02290	COG2354	Protein conserved in bacteria
I876_02295	COG4977	sequence-specific DNA binding
I876_02310	COG0004	ammonium transporteR
I876_02315	COG0405	Gamma-glutamyltransferase
I876_02320	COG2837	iron assimilation
I876_02335	COG0540	Belongs to the ATCase OTCase family
I876_02360	COG5002	protein histidine kinase activity
I876_02360	COG0784	Response regulator, receiver
I876_02360	COG2205	protein histidine kinase activity
I876_02390	COG1012	belongs to the aldehyde dehydrogenase family
I876_02400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I876_02415	COG0180	Tryptophanyl-tRNA synthetase
I876_02420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I876_02440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I876_02450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I876_02485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I876_02490	COG0281	malic enzyme
I876_02505	COG0625	glutathione transferase activity
I876_02515	COG0753	catalase activity
I876_02530	COG5001	Diguanylate cyclase
I876_02530	COG3300	MHYT domain
I876_02535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I876_02535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I876_02545	COG0137	argininosuccinate synthase activity
I876_02565	COG1803	Methylglyoxal synthase
I876_02575	COG0745	RESPONSE REGULATOR receiver
I876_02580	COG2205	protein histidine kinase activity
I876_02585	COG2267	carboxylic ester hydrolase activity
I876_02590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I876_02600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I876_02610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I876_02615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_02620	COG4942	peptidase
I876_02625	COG2861	carbohydrate metabolic process
I876_02650	COG1162	GTPase activity
I876_02655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I876_02675	COG0028	Belongs to the TPP enzyme family
I876_02700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I876_02705	COG0805	protein transport
I876_02715	COG0084	hydrolase, TatD family'
I876_02720	COG3706	GGDEF domain
I876_02720	COG5001	Diguanylate cyclase
I876_02720	COG2203	Gaf domain
I876_02720	COG4251	negative regulation of phosphorylation
I876_02730	COG0248	Ppx GppA phosphatase
I876_02735	COG0513	Belongs to the DEAD box helicase family
I876_02740	COG3118	belongs to the thioredoxin family
I876_02745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I876_02755	COG0784	Response regulator, receiver
I876_02755	COG5002	protein histidine kinase activity
I876_02760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I876_02770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I876_02780	COG0783	Belongs to the Dps family
I876_02785	COG2133	pyrroloquinoline quinone binding
I876_02790	COG4946	Tricorn protease homolog
I876_02790	COG0823	Involved in the tonB-independent uptake of proteins
I876_02790	COG1506	peptidase
I876_02800	COG3118	belongs to the thioredoxin family
I876_02815	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I876_02825	COG1012	belongs to the aldehyde dehydrogenase family
I876_02845	COG1757	Na H antiporter
I876_02860	COG3876	Protein conserved in bacteria
I876_02865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I876_02875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I876_02885	COG0346	lactoylglutathione lyase activity
I876_02910	COG2824	Alkylphosphonate utilization operon protein PhnA
I876_02915	COG0454	-acetyltransferase
I876_02940	COG3093	addiction module antidote protein HigA
I876_02955	COG2026	Addiction module toxin, RelE StbE family
I876_03010	COG1733	regulation of RNA biosynthetic process
I876_03030	COG0183	Belongs to the thiolase family
I876_03035	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_03035	COG1024	Enoyl-CoA hydratase
I876_03045	COG0006	proline dipeptidase activity
I876_03055	COG0142	geranyltranstransferase activity
I876_03085	COG4942	peptidase
I876_03085	COG1388	LysM domain
I876_03090	COG1238	metal cluster binding
I876_03100	COG0585	pseudouridine synthase activity
I876_03105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I876_03115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I876_03125	COG0840	transmembrane signaling receptor activity
I876_03165	COG0494	nUDIX hydrolase
I876_03170	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I876_03175	COG0730	response to heat
I876_03180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I876_03185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I876_03195	COG3706	GGDEF domain
I876_03195	COG0745	RESPONSE REGULATOR receiver
I876_03220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I876_03235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I876_03245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I876_03245	COG1648	precorrin-2 dehydrogenase activity
I876_03250	COG0513	Belongs to the DEAD box helicase family
I876_03270	COG1538	Outer membrane efflux protein
I876_03275	COG0494	nUDIX hydrolase
I876_03285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I876_03290	COG3150	esterase
I876_03295	COG0187	DNA topoisomerase II activity
I876_03305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I876_03330	COG1509	lysine 2,3-aminomutase activity
I876_03340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I876_03355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I876_03370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I876_03385	COG0271	Belongs to the BolA IbaG family
I876_03400	COG3707	response regulator
I876_03415	COG0659	secondary active sulfate transmembrane transporter activity
I876_03420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I876_03430	COG0243	molybdopterin cofactor binding
I876_03435	COG1648	precorrin-2 dehydrogenase activity
I876_03435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I876_03440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I876_03450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I876_03450	COG1116	anion transmembrane transporter activity
I876_03460	COG1116	anion transmembrane transporter activity
I876_03475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I876_03480	COG4206	TonB-dependent receptor
I876_03490	COG0348	domain, Protein
I876_03505	COG1960	acyl-CoA dehydrogenase activity
I876_03510	COG1028	Short-chain dehydrogenase reductase Sdr
I876_03520	COG4948	Mandelate Racemase Muconate Lactonizing
I876_03535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_03540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_03560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I876_03565	COG0358	DNA primase activity
I876_03595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I876_03600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I876_03615	COG0537	adenosine 5'-monophosphoramidase activity
I876_03630	COG3135	benzoate transporter
I876_03635	COG1396	sequence-specific DNA binding
I876_03640	COG2974	May be involved in recombination
I876_03645	COG4191	Histidine kinase
I876_03645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_03650	COG0745	RESPONSE REGULATOR receiver
I876_03655	COG5002	protein histidine kinase activity
I876_03680	COG0811	peptide transport
I876_03685	COG0811	peptide transport
I876_03690	COG0848	biopolymer transport protein
I876_03695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I876_03705	COG3437	response regulator, receiver
I876_03715	COG0318	PFAM AMP-dependent synthetase and ligase
I876_03725	COG2133	pyrroloquinoline quinone binding
I876_03730	COG1049	propionate catabolic process, 2-methylcitrate cycle
I876_03740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I876_03745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_03770	COG0527	aspartate kinase activity
I876_03780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I876_03785	COG2967	ApaG domain
I876_03795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I876_03800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_03805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I876_03810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I876_03820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I876_03840	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I876_03855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I876_03860	COG3956	TIGRFAM MazG family protein
I876_03885	COG1028	Short-chain dehydrogenase reductase Sdr
I876_03895	COG0318	PFAM AMP-dependent synthetase and ligase
I876_03905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I876_03915	COG0463	Glycosyl transferase, family 2
I876_03935	COG0642	Histidine kinase
I876_03940	COG0745	RESPONSE REGULATOR receiver
I876_03955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I876_03960	COG0723	plastoquinol--plastocyanin reductase activity
I876_03965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I876_03970	COG2857	Cytochrome c1
I876_03975	COG0625	glutathione transferase activity
I876_03980	COG2969	positive regulation of protein catabolic process
I876_03985	COG2239	Acts as a magnesium transporter
I876_03990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I876_04000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I876_04010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I876_04015	COG1137	ATPase activity
I876_04020	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I876_04030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I876_04045	COG1127	ABC transporter
I876_04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I876_04055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I876_04060	COG2854	intermembrane phospholipid transfer
I876_04070	COG5007	Belongs to the BolA IbaG family
I876_04080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I876_04085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I876_04095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I876_04130	COG4771	TonB-dependent receptor
I876_04135	COG0697	spore germination
I876_04145	COG0784	Response regulator, receiver
I876_04145	COG2205	protein histidine kinase activity
I876_04170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I876_04180	COG0126	phosphoglycerate kinase activity
I876_04185	COG3588	fructose-bisphosphate aldolase
I876_04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_04210	COG1538	Outer membrane efflux protein
I876_04215	COG4946	Tricorn protease homolog
I876_04215	COG0823	Involved in the tonB-independent uptake of proteins
I876_04215	COG1506	peptidase
I876_04220	COG0248	Ppx GppA phosphatase
I876_04225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I876_04235	COG0573	inorganic phosphate transmembrane transporter activity
I876_04245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I876_04255	COG0306	phosphate transporter
I876_04265	COG0583	DNA-binding transcription factor activity
I876_04275	COG1272	protein, Hemolysin III
I876_04280	COG1846	Transcriptional regulator
I876_04285	COG1764	response to oxidative stress
I876_04300	COG1739	Uncharacterized protein family UPF0029
I876_04310	COG0420	3'-5' exonuclease activity
I876_04315	COG0419	ATPase involved in DNA repair
I876_04325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I876_04345	COG2188	Transcriptional regulator
I876_04355	COG2986	histidine ammonia-lyase
I876_04385	COG0488	(ABC) transporter
I876_04410	COG0668	transmembrane transport
I876_04465	COG1346	cytolysis
I876_04495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I876_04505	COG0513	Belongs to the DEAD box helicase family
I876_04515	COG3267	Type II secretory pathway component ExeA
I876_04515	COG3409	Peptidoglycan-binding domain 1 protein
I876_04530	COG0066	3-isopropylmalate dehydratase activity
I876_04540	COG0473	3-isopropylmalate dehydrogenase activity
I876_04545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I876_04565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I876_04580	COG4555	ABC transporter
I876_04585	COG1668	transmembrane transport
I876_04600	COG4133	protoheme IX ABC transporter activity
I876_04605	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_04610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_04615	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I876_04625	COG1138	Cytochrome C-type biogenesis protein
I876_04630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I876_04645	COG2853	Lipoprotein
I876_04650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I876_04660	COG3104	oligopeptide transport
I876_04690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I876_04705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I876_04710	COG1596	polysaccharide export
I876_04710	COG1555	photosystem II stabilization
I876_04715	COG0473	3-isopropylmalate dehydrogenase activity
I876_04730	COG1611	Belongs to the LOG family
I876_04735	COG0745	RESPONSE REGULATOR receiver
I876_04735	COG3706	GGDEF domain
I876_04740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I876_04740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I876_04795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I876_04800	COG0024	Methionine aminopeptidase
I876_04805	COG0052	Belongs to the universal ribosomal protein uS2 family
I876_04815	COG0528	UMP kinase activity
I876_04825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I876_04830	COG0575	Belongs to the CDS family
I876_04855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I876_04875	COG0587	DNA-directed DNA polymerase activity
I876_04880	COG0825	malonyl-CoA metabolic process
I876_04885	COG0037	tRNA processing
I876_04905	COG0590	tRNA wobble adenosine to inosine editing
I876_04920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I876_04920	COG0047	phosphoribosylformylglycinamidine synthase activity
I876_04930	COG2840	Smr protein MutS2
I876_05030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I876_05075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I876_05080	COG2188	Transcriptional regulator
I876_05085	COG1228	amidohydrolase
I876_05090	COG0402	S-adenosylhomocysteine deaminase activity
I876_05135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_05140	COG2197	response regulator
I876_05180	COG0835	chemotaxis
I876_05180	COG0784	Response regulator, receiver
I876_05185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I876_05190	COG1815	bacterial-type flagellum-dependent cell motility
I876_05195	COG1558	bacterial-type flagellum-dependent cell motility
I876_05200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I876_05205	COG1749	Flagellar hook protein flgE
I876_05210	COG4787	bacterial-type flagellum-dependent cell motility
I876_05215	COG4786	Flagellar basal body rod
I876_05230	COG3951	Flagellar rod assembly protein muramidase FlgJ
I876_05230	COG1705	Flagellar rod assembly protein muramidase FlgJ
I876_05235	COG1256	bacterial-type flagellum assembly
I876_05265	COG1334	flagellar protein FlaG
I876_05270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I876_05300	COG2089	acid synthase
I876_05305	COG3980	spore coat polysaccharide biosynthesis protein
I876_05310	COG1083	cytidylyl-transferase
I876_05315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I876_05320	COG1086	Polysaccharide biosynthesis protein
I876_05330	COG2204	response regulator
I876_05335	COG3852	Histidine kinase
I876_05340	COG2204	response regulator
I876_05345	COG1677	Flagellar hook-basal body complex protein FliE
I876_05350	COG1766	The M ring may be actively involved in energy transduction
I876_05355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I876_05405	COG1987	bacterial-type flagellum assembly
I876_05420	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I876_05430	COG0455	bacterial-type flagellum organization
I876_05445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I876_05450	COG2198	Histidine kinase
I876_05450	COG0643	Histidine kinase
I876_05460	COG1192	Involved in chromosome partitioning
I876_05470	COG0835	chemotaxis
I876_05485	COG0646	methionine synthase
I876_05485	COG1410	methionine synthase
I876_05490	COG0646	methionine synthase
I876_05490	COG1410	methionine synthase
I876_05500	COG3123	guanosine phosphorylase activity
I876_05505	COG0583	DNA-binding transcription factor activity
I876_05510	COG0583	DNA-binding transcription factor activity
I876_05520	COG0659	secondary active sulfate transmembrane transporter activity
I876_05535	COG3590	peptidase
I876_05545	COG2137	regulation of response to DNA damage stimulus
I876_05550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I876_05570	COG0511	ligase activity, forming carbon-carbon bonds
I876_05570	COG5016	pyruvate
I876_05575	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I876_05580	COG4172	Belongs to the ABC transporter superfamily
I876_05590	COG4171	peptide transport system, permease
I876_05595	COG4168	peptide transport system, permease
I876_05600	COG0747	negative chemotaxis
I876_05605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I876_05610	COG1842	Phage shock protein A
I876_05640	COG0625	glutathione transferase activity
I876_05645	COG1522	sequence-specific DNA binding
I876_05710	COG0811	peptide transport
I876_05715	COG0811	peptide transport
I876_05720	COG0848	biopolymer transport protein
I876_05735	COG1444	tRNA N-acetyltransferase activity
I876_05770	COG0456	acetyltransferase
I876_05780	COG0583	DNA-binding transcription factor activity
I876_05785	COG2814	Major facilitator Superfamily
I876_05795	COG0656	L-ascorbic acid biosynthetic process
I876_05810	COG1846	Transcriptional regulator
I876_05855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I876_05865	COG3706	GGDEF domain
I876_05890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I876_05890	COG0543	2 iron, 2 sulfur cluster binding
I876_05900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I876_05905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I876_05910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I876_05915	COG0564	pseudouridine synthase activity
I876_05925	COG0612	Peptidase, M16
I876_05930	COG2918	glutathione biosynthetic process
I876_05955	COG2840	Smr protein MutS2
I876_05960	COG2890	protein-(glutamine-N5) methyltransferase activity
I876_05975	COG2719	SpoVR family
I876_05980	COG2718	Belongs to the UPF0229 family
I876_05985	COG2766	serine protein kinase
I876_05995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I876_06000	COG4771	TonB-dependent receptor
I876_06025	COG0450	alkyl hydroperoxide reductase
I876_06030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I876_06035	COG2885	chlorophyll binding
I876_06040	COG0584	glycerophosphoryl diester phosphodiesterase
I876_06045	COG0346	lactoylglutathione lyase activity
I876_06050	COG1278	Cold shock
I876_06065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I876_06070	COG4660	Part of a membrane complex involved in electron transport
I876_06075	COG4659	FMN binding
I876_06080	COG4658	electron transport chain
I876_06085	COG4656	Part of a membrane complex involved in electron transport
I876_06090	COG2878	Part of a membrane complex involved in electron transport
I876_06100	COG0534	Mate efflux family protein
I876_06105	COG0556	nucleotide-excision repair
I876_06120	COG0602	queuosine metabolic process
I876_06130	COG0367	asparagine synthase
I876_06155	COG0471	metal ion transport
I876_06155	COG3273	potassium ion transport
I876_06170	COG0529	Catalyzes the synthesis of activated sulfate
I876_06175	COG0175	sulfate reduction
I876_06180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_06185	COG3706	GGDEF domain
I876_06210	COG2304	oxidoreductase activity
I876_06230	COG0714	Associated with various cellular activities
I876_06240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_06240	COG1024	Enoyl-CoA hydratase
I876_06260	COG1025	Belongs to the peptidase M16 family
I876_06265	COG2062	phosphohistidine phosphatase, SixA
I876_06275	COG4536	flavin adenine dinucleotide binding
I876_06280	COG4137	Cytochrome C assembly protein
I876_06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I876_06340	COG1132	(ABC) transporter
I876_06355	COG0228	four-way junction DNA binding
I876_06360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I876_06365	COG0336	Belongs to the RNA methyltransferase TrmD family
I876_06370	COG0335	large ribosomal subunit rRNA binding
I876_06375	COG2860	membrane
I876_06385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I876_06390	COG0287	Prephenate dehydrogenase
I876_06390	COG1605	Chorismate mutase
I876_06395	COG0077	Prephenate dehydratase
I876_06395	COG1605	Chorismate mutase
I876_06405	COG0023	Translation Initiation Factor
I876_06435	COG2205	protein histidine kinase activity
I876_06445	COG2204	response regulator
I876_06465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I876_06470	COG0494	nUDIX hydrolase
I876_06475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I876_06485	COG2255	four-way junction helicase activity
I876_06490	COG0824	Thioesterase
I876_06495	COG0811	peptide transport
I876_06510	COG0823	Involved in the tonB-independent uptake of proteins
I876_06515	COG2885	chlorophyll binding
I876_06520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I876_06525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I876_06535	COG4667	esterase of the alpha-beta hydrolase superfamily
I876_06540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I876_06555	COG1028	Short-chain dehydrogenase reductase Sdr
I876_06560	COG3038	cytochrome b561
I876_06590	COG1451	nucleotide metabolic process
I876_06600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_06610	COG1309	transcriptional regulator
I876_06615	COG4774	siderophore transport
I876_06635	COG3706	GGDEF domain
I876_06645	COG3008	intermembrane lipid transfer
I876_06645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I876_06650	COG2995	paraquat-inducible protein a
I876_06665	COG0017	Asparaginyl-tRNA synthetase
I876_06680	COG0189	ligase activity
I876_06710	COG0156	8-amino-7-oxononanoate synthase activity
I876_06715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_06725	COG3340	Belongs to the peptidase S51 family
I876_06730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I876_06735	COG4139	cobalamin transport
I876_06740	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I876_06745	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I876_06760	COG5265	(ABC) transporter
I876_06765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I876_06775	COG0745	RESPONSE REGULATOR receiver
I876_06780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I876_06800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_06815	COG2755	lipolytic protein G-D-S-L family
I876_06820	COG4181	ATPase activity
I876_06825	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I876_06830	COG1090	epimerase
I876_06835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I876_06840	COG0628	permease
I876_06850	COG0745	RESPONSE REGULATOR receiver
I876_06865	COG2350	Protein conserved in bacteria
I876_06870	COG0159	tryptophan synthase activity
I876_06880	COG0135	phosphoribosylanthranilate isomerase activity
I876_06880	COG0134	indole-3-glycerol-phosphate synthase activity
I876_06885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I876_06895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I876_06900	COG0613	PHP domain protein
I876_06905	COG0009	L-threonylcarbamoyladenylate synthase
I876_06910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I876_06915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I876_06925	COG0656	L-ascorbic acid biosynthetic process
I876_06930	COG0110	maltose O-acetyltransferase activity
I876_06940	COG2733	membrane
I876_06945	COG0500	methyltransferase
I876_06950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_06955	COG0497	DNA recombination
I876_06960	COG0783	Belongs to the Dps family
I876_06970	COG1454	alcohol dehydrogenase
I876_06975	COG1028	Short-chain dehydrogenase reductase Sdr
I876_06985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I876_06990	COG2610	gluconate transmembrane transporter activity
I876_07005	COG2205	protein histidine kinase activity
I876_07005	COG2198	Histidine kinase
I876_07005	COG0784	Response regulator, receiver
I876_07010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I876_07020	COG0484	heat shock protein binding
I876_07025	COG3909	cytochrome
I876_07030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I876_07045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I876_07050	COG0505	Belongs to the CarA family
I876_07055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I876_07060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I876_07080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I876_07085	COG0857	belongs to the CobB CobQ family
I876_07085	COG0280	phosphate acetyltransferase
I876_07100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I876_07105	COG4535	Mg2 and Co2 transporter CorC
I876_07115	COG1702	phosphate starvation-inducible protein PhoH
I876_07125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I876_07165	COG1607	acyl-coa hydrolase
I876_07170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I876_07180	COG1115	amino acid carrier protein
I876_07190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I876_07195	COG0012	GTP binding
I876_07210	COG1064	alcohol dehydrogenase
I876_07225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I876_07230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I876_07235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I876_07240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I876_07250	COG2890	protein-(glutamine-N5) methyltransferase activity
I876_07255	COG3437	response regulator, receiver
I876_07255	COG0784	Response regulator, receiver
I876_07265	COG3094	Invasion gene expression up-regulator, SirB
I876_07280	COG0583	DNA-binding transcription factor activity
I876_07290	COG2363	Small membrane protein
I876_07305	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I876_07310	COG0515	serine threonine protein kinase
I876_07315	COG2116	formate transmembrane transporter activity
I876_07330	COG0714	Associated with various cellular activities
I876_07335	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I876_07340	COG0033	Phosphoglucomutase
I876_07345	COG0058	SHG alpha-glucan phosphorylase activity
I876_07355	COG2988	succinylglutamate desuccinylase activity
I876_07390	COG1393	Belongs to the ArsC family
I876_07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I876_07490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I876_07490	COG0475	glutathione-regulated potassium exporter activity
I876_07505	COG1733	regulation of RNA biosynthetic process
I876_07510	COG5001	Diguanylate cyclase
I876_07510	COG5002	protein histidine kinase activity
I876_07510	COG3447	MASE1 domain protein
I876_07520	COG0402	S-adenosylhomocysteine deaminase activity
I876_07525	COG2351	hydroxyisourate hydrolase activity
I876_07540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_07555	COG1309	transcriptional regulator
I876_07570	COG2252	PERMEase
I876_07575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I876_07590	COG3706	GGDEF domain
I876_07590	COG2203	Gaf domain
I876_07590	COG5001	Diguanylate cyclase
I876_07590	COG4251	negative regulation of phosphorylation
I876_07595	COG4251	negative regulation of phosphorylation
I876_07595	COG2203	Gaf domain
I876_07595	COG5001	Diguanylate cyclase
I876_07595	COG3706	GGDEF domain
I876_07600	COG0784	Response regulator, receiver
I876_07600	COG2205	protein histidine kinase activity
I876_07615	COG2233	PERMEase
I876_07630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I876_07635	COG0730	response to heat
I876_07680	COG1028	Short-chain dehydrogenase reductase Sdr
I876_07695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I876_07730	COG1596	polysaccharide export
I876_07735	COG0489	protein tyrosine kinase activity
I876_07740	COG4464	protein tyrosine phosphatase activity
I876_07765	COG3300	MHYT domain
I876_07765	COG5001	Diguanylate cyclase
I876_07775	COG0297	glycogen (starch) synthase activity
I876_07790	COG1215	transferase activity, transferring glycosyl groups
I876_07795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I876_07800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I876_07830	COG0297	glycogen (starch) synthase activity
I876_07845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_07845	COG0072	phenylalanine-tRNA ligase activity
I876_07860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I876_07870	COG1472	Belongs to the glycosyl hydrolase 3 family
I876_07875	COG2096	Adenosyltransferase
I876_07885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I876_07895	COG4591	ABC-type transport system involved in lipoprotein release permease component
I876_07920	COG0708	Exodeoxyribonuclease III
I876_07955	COG2814	Major facilitator Superfamily
I876_08000	COG1024	Enoyl-CoA hydratase
I876_08005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I876_08010	COG1960	acyl-CoA dehydrogenase activity
I876_08015	COG0789	Transcriptional regulator
I876_08020	COG0183	Belongs to the thiolase family
I876_08035	COG3706	GGDEF domain
I876_08045	COG2925	Exonuclease
I876_08105	COG1643	Atp-dependent helicase
I876_08125	COG3321	synthase
I876_08125	COG0604	alcohol dehydrogenase
I876_08130	COG0328	RNA-DNA hybrid ribonuclease activity
I876_08135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I876_08145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I876_08155	COG4591	ABC-type transport system involved in lipoprotein release permease component
I876_08160	COG1301	dicarboxylic acid transport
I876_08170	COG3724	N-succinylarginine dihydrolase activity
I876_08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I876_08205	COG0746	molybdenum cofactor guanylyltransferase activity
I876_08210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I876_08215	COG0243	molybdopterin cofactor binding
I876_08220	COG2153	protein acetylation
I876_08235	COG1530	ribonuclease E activity
I876_08250	COG0424	maF-like protein
I876_08255	COG1399	metal-binding, possibly nucleic acid-binding protein
I876_08265	COG0416	fatty acid biosynthetic process
I876_08270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I876_08275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I876_08285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I876_08290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I876_08300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I876_08315	COG0084	hydrolase, TatD family'
I876_08325	COG0702	epimerase
I876_08330	COG3706	GGDEF domain
I876_08350	COG1028	Short-chain dehydrogenase reductase Sdr
I876_08355	COG0596	Alpha beta hydrolase
I876_08365	COG0183	Belongs to the thiolase family
I876_08370	COG1960	acyl-CoA dehydrogenase activity
I876_08390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I876_08400	COG0246	Mannitol dehydrogenase
I876_08425	COG0668	transmembrane transport
I876_08430	COG4771	TonB-dependent receptor
I876_08445	COG3437	response regulator, receiver
I876_08455	COG0195	Participates in both transcription termination and antitermination
I876_08470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I876_08485	COG1187	pseudouridine synthase activity
I876_08495	COG3153	acetyltransferase
I876_08495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_08535	COG0450	alkyl hydroperoxide reductase
I876_08580	COG1032	radical SAM domain protein
I876_08595	COG4771	TonB-dependent receptor
I876_08600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_08610	COG4134	Bacterial extracellular solute-binding protein
I876_08620	COG4136	ATPase activity
I876_08625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I876_08645	COG2203	Gaf domain
I876_08645	COG3706	GGDEF domain
I876_08645	COG5001	Diguanylate cyclase
I876_08645	COG4251	negative regulation of phosphorylation
I876_08685	COG2801	Transposase and inactivated derivatives
I876_08695	COG1902	pentaerythritol trinitrate reductase activity
I876_08705	COG2867	negative regulation of translational initiation
I876_08710	COG2914	Belongs to the UPF0125 (RnfH) family
I876_08720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_08725	COG4771	TonB-dependent receptor
I876_08735	COG0457	Tetratricopeptide repeat
I876_08750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I876_08750	COG0574	Belongs to the PEP-utilizing enzyme family
I876_08790	COG2850	peptidyl-arginine hydroxylation
I876_08800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I876_08805	COG2915	High frequency lysogenization protein hflD homolog
I876_08810	COG0482	sulfurtransferase activity
I876_08815	COG1187	pseudouridine synthase activity
I876_08825	COG1278	Cold shock
I876_08830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I876_08835	COG0542	response to heat
I876_08840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I876_08845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I876_08850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I876_08855	COG0492	ferredoxin-NADP+ reductase activity
I876_08860	COG3092	negative regulation of chromosome organization
I876_08865	COG3091	SprT-like family
I876_08870	COG0616	signal peptide processing
I876_08885	COG0778	Nitroreductase
I876_08895	COG0252	asparaginase activity
I876_08900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I876_08905	COG0321	lipoyl(octanoyl) transferase activity
I876_08910	COG2921	Belongs to the UPF0250 family
I876_08915	COG1686	Belongs to the peptidase S11 family
I876_08920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I876_08925	COG0772	Belongs to the SEDS family
I876_08930	COG0768	penicillin binding
I876_08935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I876_08940	COG0799	negative regulation of ribosome biogenesis
I876_08945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I876_08950	COG1466	dna polymerase III delta subunit
I876_08955	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I876_08960	COG0495	leucyl-tRNA aminoacylation
I876_08975	COG1067	ATP-dependent peptidase activity
I876_08980	COG0596	Alpha beta hydrolase
I876_08985	COG3706	GGDEF domain
I876_08995	COG1534	Rna-binding protein
I876_09000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I876_09005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I876_09010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I876_09015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I876_09020	COG0149	triose-phosphate isomerase activity
I876_09025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I876_09030	COG5001	Diguanylate cyclase
I876_09030	COG3300	MHYT domain
I876_09050	COG1803	Methylglyoxal synthase
I876_09050	COG1597	lipid kinase activity
I876_09060	COG1028	Short-chain dehydrogenase reductase Sdr
I876_09065	COG0561	phosphatase activity
I876_09080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_09105	COG1185	polyribonucleotide nucleotidyltransferase activity
I876_09140	COG3547	Transposase (IS116 IS110 IS902 family)
I876_09150	COG3547	Transposase (IS116 IS110 IS902 family)
I876_09240	COG3550	peptidyl-serine autophosphorylation
I876_09245	COG2801	Transposase and inactivated derivatives
I876_09385	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I876_09390	COG1196	nuclear chromosome segregation
I876_09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I876_09415	COG1132	(ABC) transporter
I876_09420	COG1663	tetraacyldisaccharide 4'-kinase activity
I876_09455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I876_09460	COG0435	Glutathione S-transferase
I876_09465	COG1741	Belongs to the pirin family
I876_09470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I876_09480	COG0372	Belongs to the citrate synthase family
I876_09485	COG2009	succinate dehydrogenase
I876_09490	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I876_09495	COG1053	succinate dehydrogenase
I876_09500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I876_09505	COG0567	Dehydrogenase, E1 component
I876_09510	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_09550	COG4667	esterase of the alpha-beta hydrolase superfamily
I876_09570	COG0366	Alpha amylase catalytic
I876_09595	COG1028	Short-chain dehydrogenase reductase Sdr
I876_09600	COG2267	carboxylic ester hydrolase activity
I876_09610	COG0616	signal peptide processing
I876_09630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_09635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I876_09640	COG0386	Belongs to the glutathione peroxidase family
I876_09645	COG2084	Dehydrogenase
I876_09655	COG1960	acyl-CoA dehydrogenase activity
I876_09660	COG1024	Enoyl-CoA hydratase
I876_09670	COG2226	methyltransferase
I876_09675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I876_09680	COG3083	sulfuric ester hydrolase activity
I876_09685	COG3082	Protein of unknown function (DUF1414)
I876_09690	COG3081	Nucleoid-associated protein
I876_09720	COG3275	phosphorelay sensor kinase activity
I876_09725	COG3279	Response regulator of the LytR AlgR family
I876_09730	COG0205	6-phosphofructokinase activity
I876_09740	COG3344	reverse transcriptase
I876_09805	COG2201	protein-glutamate methylesterase activity
I876_09830	COG0675	Transposase, IS605 OrfB family
I876_09875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_09935	COG4221	oxidoreductase activity
I876_09940	COG0583	DNA-binding transcription factor activity
I876_09950	COG3550	peptidyl-serine autophosphorylation
I876_09955	COG3550	peptidyl-serine autophosphorylation
I876_09980	COG3039	Transposase
I876_09990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_10005	COG2205	protein histidine kinase activity
I876_10005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_10025	COG0513	Belongs to the DEAD box helicase family
I876_10035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I876_10040	COG0583	DNA-binding transcription factor activity
I876_10060	COG1760	l-serine dehydratase
I876_10085	COG1322	Protein conserved in bacteria
I876_10090	COG1404	Belongs to the peptidase S8 family
I876_10095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I876_10100	COG0022	dehydrogenase e1 component
I876_10110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I876_10115	COG0515	serine threonine protein kinase
I876_10120	COG1946	Acyl-CoA thioesterase
I876_10130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I876_10140	COG1956	GAF domain-containing protein
I876_10155	COG0793	Belongs to the peptidase S41A family
I876_10160	COG0733	neurotransmitter:sodium symporter activity
I876_10170	COG0308	aminopeptidase N
I876_10205	COG2902	Dehydrogenase
I876_10210	COG0167	dihydroorotate dehydrogenase activity
I876_10235	COG3130	regulation of translation
I876_10240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I876_10250	COG0415	Belongs to the DNA photolyase family
I876_10270	COG2059	Chromate
I876_10285	COG3300	MHYT domain
I876_10285	COG5001	Diguanylate cyclase
I876_10290	COG0840	transmembrane signaling receptor activity
I876_10300	COG5001	Diguanylate cyclase
I876_10300	COG3447	MASE1 domain protein
I876_10300	COG5002	protein histidine kinase activity
I876_10340	COG1192	Involved in chromosome partitioning
I876_10355	COG1484	DNA-dependent DNA replication
I876_10360	COG0415	Belongs to the DNA photolyase family
I876_10365	COG0415	Belongs to the DNA photolyase family
I876_10370	COG0415	Belongs to the DNA photolyase family
I876_10375	COG0415	Belongs to the DNA photolyase family
I876_10380	COG3046	protein related to deoxyribodipyrimidine photolyase
I876_10400	COG4974	Belongs to the 'phage' integrase family
I876_10410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I876_10415	COG0589	response to stress
I876_10425	COG0069	glutamate synthase activity
I876_10440	COG2193	ferroxidase activity
I876_10450	COG3278	Belongs to the heme-copper respiratory oxidase family
I876_10465	COG2010	Cytochrome c
I876_10490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I876_10495	COG0589	response to stress
I876_10500	COG0037	tRNA processing
I876_10505	COG1752	Esterase of the alpha-beta hydrolase superfamily
I876_10525	COG1280	lysine exporter protein (LysE YggA)
I876_10530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I876_10535	COG2897	thiosulfate sulfurtransferase activity
I876_10540	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I876_10625	COG0582	viral genome integration into host DNA
I876_10635	COG0322	excinuclease ABC activity
I876_10640	COG2197	response regulator
I876_10645	COG0436	Aminotransferase
I876_10665	COG2259	Doxx family
I876_10670	COG0583	DNA-binding transcription factor activity
I876_10685	COG0670	Belongs to the BI1 family
I876_10690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I876_10705	COG2920	part of a sulfur-relay system
I876_10745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I876_10755	COG1674	ftsk spoiiie
I876_10755	COG0531	amino acid
I876_10765	COG0686	Belongs to the AlaDH PNT family
I876_10770	COG0284	orotidine-5'-phosphate decarboxylase activity
I876_10775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I876_10790	COG0776	regulation of translation
I876_10795	COG0539	negative regulation of cytoplasmic translation
I876_10800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I876_10805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I876_10810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I876_10820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I876_10825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I876_10830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I876_10835	COG0633	Ferredoxin
I876_10870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I876_10875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I876_10885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I876_10895	COG4783	chaperone-mediated protein folding
I876_10905	COG1393	Belongs to the ArsC family
I876_10920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I876_10935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I876_10945	COG1960	acyl-CoA dehydrogenase activity
I876_10970	COG0572	uridine kinase
I876_10975	COG3769	mannosylglycerate metabolic process
I876_10980	COG1215	transferase activity, transferring glycosyl groups
I876_10985	COG0366	Alpha amylase catalytic
I876_10995	COG0303	'Molybdopterin
I876_11000	COG0534	Mate efflux family protein
I876_11015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I876_11020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I876_11040	COG3547	Transposase (IS116 IS110 IS902 family)
I876_11060	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I876_11080	COG3547	Transposase (IS116 IS110 IS902 family)
I876_11110	COG0405	Gamma-glutamyltransferase
I876_11115	COG1024	Enoyl-CoA hydratase
I876_11160	COG1448	Aminotransferase
I876_11180	COG1671	Belongs to the UPF0178 family
I876_11185	COG1028	Short-chain dehydrogenase reductase Sdr
I876_11190	COG1028	Short-chain dehydrogenase reductase Sdr
I876_11195	COG1960	acyl-CoA dehydrogenase activity
I876_11200	COG0662	Cupin 2, conserved barrel domain protein
I876_11200	COG2207	Transcriptional regulator
I876_11205	COG4771	TonB-dependent receptor
I876_11220	COG1505	serine-type exopeptidase activity
I876_11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_11260	COG0596	Alpha beta hydrolase
I876_11270	COG0716	FMN binding
I876_11280	COG0735	belongs to the Fur family
I876_11290	COG1984	allophanate hydrolase subunit 2
I876_11295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I876_11300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I876_11305	COG2996	Protein conserved in bacteria
I876_11310	COG1765	OsmC-like protein
I876_11315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_11325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_11340	COG0436	Aminotransferase
I876_11345	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_11350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_11360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_11360	COG2010	Cytochrome c
I876_11365	COG2080	2 iron, 2 sulfur cluster binding
I876_11390	COG1073	alpha beta
I876_11395	COG2207	Transcriptional regulator
I876_11405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_11410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I876_11435	COG3012	SEC-C Motif Domain Protein
I876_11445	COG0604	alcohol dehydrogenase
I876_11455	COG1960	acyl-CoA dehydrogenase activity
I876_11465	COG4771	TonB-dependent receptor
I876_11485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I876_11490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I876_11510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I876_11520	COG0521	Mo-molybdopterin cofactor biosynthetic process
I876_11540	COG2161	toxin-antitoxin pair type II binding
I876_11545	COG4115	mRNA cleavage
I876_11560	COG0436	Aminotransferase
I876_11565	COG3268	Saccharopine dehydrogenase
I876_11570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I876_11585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I876_11590	COG4206	TonB-dependent receptor
I876_11600	COG5006	permease, DMT superfamily
I876_11615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I876_11620	COG1074	ATP-dependent DNA helicase activity
I876_11625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I876_11640	COG1022	Amp-dependent synthetase and ligase
I876_11645	COG2203	Gaf domain
I876_11645	COG4251	negative regulation of phosphorylation
I876_11645	COG5001	Diguanylate cyclase
I876_11645	COG3706	GGDEF domain
I876_11665	COG0583	DNA-binding transcription factor activity
I876_11685	COG0640	Transcriptional regulator
I876_11705	COG2204	response regulator
I876_11715	COG4251	negative regulation of phosphorylation
I876_11720	COG0784	Response regulator, receiver
I876_11725	COG0784	Response regulator, receiver
I876_11725	COG2205	protein histidine kinase activity
I876_11750	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I876_11775	COG3139	Protein of unknown function (DUF1315)
I876_11790	COG1115	amino acid carrier protein
I876_11795	COG2866	Carboxypeptidase
I876_11815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I876_11825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I876_11830	COG1640	4-alpha-glucanotransferase
I876_11835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I876_11840	COG0676	glucose-6-phosphate 1-epimerase activity
I876_11845	COG0800	Aldolase
I876_11855	COG0129	dihydroxy-acid dehydratase activity
I876_11865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I876_11870	COG1737	Transcriptional regulator
I876_11875	COG0469	pyruvate kinase activity
I876_11880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_11900	COG2823	Periplasmic or secreted lipoprotein
I876_11930	COG3665	Urea carboxylase-associated protein
I876_11955	COG1028	Short-chain dehydrogenase reductase Sdr
I876_11970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I876_11985	COG2721	sulfolactate sulfo-lyase activity
I876_11990	COG1904	glucuronate isomerase
I876_11995	COG0246	Mannitol dehydrogenase
I876_12000	COG0800	Aldolase
I876_12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_12010	COG2755	lipolytic protein G-D-S-L family
I876_12020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I876_12030	COG4677	pectinesterase activity
I876_12050	COG2356	endonuclease I
I876_12055	COG0840	transmembrane signaling receptor activity
I876_12070	COG0583	DNA-binding transcription factor activity
I876_12075	COG1979	alcohol dehydrogenase
I876_12080	COG5001	Diguanylate cyclase
I876_12090	COG0784	Response regulator, receiver
I876_12090	COG3437	response regulator, receiver
I876_12095	COG4191	Histidine kinase
I876_12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_12105	COG0471	metal ion transport
I876_12115	COG0489	protein tyrosine kinase activity
I876_12120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_12120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I876_12125	COG0668	transmembrane transport
I876_12130	COG2226	methyltransferase
I876_12135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_12140	COG1388	LysM domain
I876_12140	COG0741	lytic transglycosylase activity
I876_12165	COG0215	cysteine-tRNA ligase activity
I876_12170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I876_12180	COG1785	Belongs to the alkaline phosphatase family
I876_12185	COG1785	Belongs to the alkaline phosphatase family
I876_12200	COG2268	Band 7 protein
I876_12205	COG0583	DNA-binding transcription factor activity
I876_12210	COG1028	Short-chain dehydrogenase reductase Sdr
I876_12225	COG1733	regulation of RNA biosynthetic process
I876_12230	COG0604	alcohol dehydrogenase
I876_12235	COG0753	catalase activity
I876_12240	COG0604	alcohol dehydrogenase
I876_12245	COG0583	DNA-binding transcription factor activity
I876_12270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I876_12275	COG1286	toxin biosynthetic process
I876_12280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I876_12285	COG0285	dihydrofolate synthase activity
I876_12320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I876_12340	COG3609	addiction module antidote protein, CC2985 family
I876_12345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I876_12350	COG0318	PFAM AMP-dependent synthetase and ligase
I876_12360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I876_12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I876_12395	COG0789	Transcriptional regulator
I876_12400	COG0604	alcohol dehydrogenase
I876_12415	COG1119	ATPase activity
I876_12420	COG2031	fatty acid transporter
I876_12425	COG2205	protein histidine kinase activity
I876_12425	COG0784	Response regulator, receiver
I876_12425	COG5002	protein histidine kinase activity
I876_12435	COG0612	Peptidase, M16
I876_12450	COG3101	peptidyl-lysine hydroxylation
I876_12475	COG1902	pentaerythritol trinitrate reductase activity
I876_12475	COG0446	pyridine nucleotide-disulphide oxidoreductase
I876_12510	COG4399	Belongs to the UPF0754 family
I876_12535	COG1770	oligopeptidase
I876_12540	COG2186	Transcriptional regulator
I876_12550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I876_12555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I876_12565	COG2983	Belongs to the UPF0260 family
I876_12570	COG0179	Fumarylacetoacetate (FAA) hydrolase
I876_12585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I876_12590	COG0318	PFAM AMP-dependent synthetase and ligase
I876_12595	COG2267	carboxylic ester hydrolase activity
I876_12610	COG1214	PFAM Peptidase M22, glycoprotease
I876_12615	COG1199	ATP-dependent helicase activity
I876_12665	COG4771	TonB-dependent receptor
I876_12675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I876_12680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I876_12685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I876_12690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I876_12690	COG0131	Imidazoleglycerol-phosphate dehydratase
I876_12695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I876_12710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I876_12710	COG0140	phosphoribosyl-ATP diphosphatase activity
I876_12725	COG2116	formate transmembrane transporter activity
I876_12730	COG0612	Peptidase, M16
I876_12755	COG0326	Molecular chaperone. Has ATPase activity
I876_12760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I876_12780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I876_12785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I876_12795	COG3220	belongs to the UPF0276 family
I876_12805	COG1136	(ABC) transporter
I876_12805	COG0577	efflux transmembrane transporter activity
I876_12815	COG2203	Gaf domain
I876_12815	COG3706	GGDEF domain
I876_12815	COG5001	Diguanylate cyclase
I876_12815	COG4251	negative regulation of phosphorylation
I876_12820	COG1183	phosphatidylcholine synthase activity
I876_12835	COG0457	Tetratricopeptide repeat
I876_12840	COG0277	FAD linked oxidase domain protein
I876_12845	COG0542	response to heat
I876_12855	COG0564	pseudouridine synthase activity
I876_12870	COG1595	DNA-templated transcription, initiation
I876_12885	COG4221	oxidoreductase activity
I876_12900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I876_12910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I876_12920	COG0142	geranyltranstransferase activity
I876_12930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I876_12935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I876_12945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I876_12960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I876_12960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I876_12980	COG0488	(ABC) transporter
I876_12990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I876_13000	COG0560	Phosphoserine phosphatase
I876_13010	COG0084	hydrolase, TatD family'
I876_13025	COG0571	ribonuclease III activity
I876_13030	COG0681	Belongs to the peptidase S26 family
I876_13055	COG1595	DNA-templated transcription, initiation
I876_13065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I876_13080	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I876_13160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I876_13165	COG1047	Peptidyl-prolyl cis-trans
I876_13175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I876_13180	COG0196	riboflavin kinase activity
I876_13185	COG0728	peptidoglycan biosynthetic process
I876_13190	COG0268	Binds directly to 16S ribosomal RNA
I876_13210	COG0385	Bile acid
I876_13240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_13245	COG0776	regulation of translation
I876_13250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I876_13255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I876_13260	COG0740	serine-type endopeptidase activity
I876_13265	COG0544	peptidyl-prolyl cis-trans isomerase activity
I876_13280	COG1720	tRNA m6t6A37 methyltransferase activity
I876_13290	COG1234	tRNA 3'-trailer cleavage
I876_13300	COG0123	including yeast histone deacetylase and acetoin utilization protein
I876_13325	COG0516	GMP reductase activity
I876_13325	COG0517	IMP dehydrogenase activity
I876_13330	COG1570	exodeoxyribonuclease VII activity
I876_13350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I876_13355	COG2976	Protein conserved in bacteria
I876_13380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I876_13390	COG2166	iron-sulfur cluster assembly
I876_13405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I876_13410	COG0719	Fe-S assembly protein
I876_13415	COG0396	ATPase activity
I876_13420	COG0719	Fe-S assembly protein
I876_13425	COG1104	cysteine desulfurase activity
I876_13430	COG1959	2 iron, 2 sulfur cluster binding
I876_13435	COG2072	flavoprotein involved in K transport
I876_13440	COG1045	serine acetyltransferase
I876_13445	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I876_13450	COG0483	inositol monophosphate 1-phosphatase activity
I876_13465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I876_13470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I876_13475	COG1862	Preprotein translocase
I876_13480	COG0343	queuine tRNA-ribosyltransferase activity
I876_13500	COG1842	Phage shock protein A
I876_13505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I876_13525	COG0754	glutathionylspermidine amidase activity
I876_13555	COG2066	Belongs to the glutaminase family
I876_13560	COG1785	Belongs to the alkaline phosphatase family
I876_13625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I876_13650	COG2171	N-acyltransferase activity
I876_13670	COG0438	transferase activity, transferring glycosyl groups
I876_13685	COG0367	asparagine synthase
I876_13690	COG0438	transferase activity, transferring glycosyl groups
I876_13710	COG0110	maltose O-acetyltransferase activity
I876_13715	COG2244	polysaccharide biosynthetic process
I876_13740	COG2327	Polysaccharide pyruvyl transferase
I876_13780	COG0489	protein tyrosine kinase activity
I876_13790	COG3267	Type II secretory pathway component ExeA
I876_13790	COG3409	Peptidoglycan-binding domain 1 protein
I876_13795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I876_13795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I876_13825	COG1560	Kdo2-lipid A biosynthetic process
I876_13840	COG1960	acyl-CoA dehydrogenase activity
I876_13855	COG5001	Diguanylate cyclase
I876_13855	COG3300	MHYT domain
I876_13860	COG1435	thymidine kinase activity
I876_13870	COG1609	Transcriptional regulator
I876_13875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I876_13915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I876_13920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I876_13925	COG1250	3-hydroxyacyl-CoA dehydrogenase
I876_13925	COG1024	Enoyl-CoA hydratase
I876_13940	COG1012	belongs to the aldehyde dehydrogenase family
I876_13960	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I876_13965	COG0789	Transcriptional regulator
I876_13995	COG1960	acyl-CoA dehydrogenase activity
I876_14025	COG0745	RESPONSE REGULATOR receiver
I876_14030	COG2205	protein histidine kinase activity
I876_14070	COG2080	2 iron, 2 sulfur cluster binding
I876_14075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I876_14080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I876_14100	COG1028	Short-chain dehydrogenase reductase Sdr
I876_14105	COG4221	oxidoreductase activity
I876_14110	COG0693	protein deglycase activity
I876_14115	COG1295	ribonuclease BN
I876_14125	COG4681	YaeQ
I876_14155	COG2814	Major facilitator Superfamily
I876_14170	COG0514	ATP-dependent DNA helicase (RecQ)
I876_14200	COG4251	negative regulation of phosphorylation
I876_14210	COG2133	pyrroloquinoline quinone binding
I876_14225	COG0830	nickel cation binding
I876_14250	COG0829	nickel cation binding
I876_14255	COG0410	ABC transporter
I876_14290	COG0745	RESPONSE REGULATOR receiver
I876_14295	COG1484	DNA-dependent DNA replication
I876_14305	COG3177	Filamentation induced by cAMP protein fic
I876_14345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I876_14445	COG4772	TonB-dependent receptor
I876_14480	COG1230	cation diffusion facilitator family transporter
I876_14490	COG4372	Transposase
I876_14515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I876_14520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I876_14525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I876_14545	COG3313	Fe-S protein
I876_14575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_14580	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_14585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I876_14590	COG2186	Transcriptional regulator
I876_14600	COG3023	N-Acetylmuramoyl-L-alanine amidase
I876_14605	COG3577	Aspartyl protease
I876_14610	COG0157	Belongs to the NadC ModD family
I876_14615	COG4969	Belongs to the N-Me-Phe pilin family
I876_14620	COG1459	type II secretion system
I876_14630	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I876_14630	COG0237	dephospho-CoA kinase activity
I876_14635	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I876_14645	COG3608	succinylglutamate desuccinylase aspartoacylase
I876_14650	COG0494	nUDIX hydrolase
I876_14660	COG0739	heme binding
I876_14665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I876_14670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I876_14675	COG0849	cell division
I876_14680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I876_14685	COG1181	Belongs to the D-alanine--D-alanine ligase family
I876_14690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I876_14700	COG0772	Belongs to the SEDS family
I876_14705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I876_14715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I876_14720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I876_14725	COG0768	penicillin binding
I876_14730	COG3116	cell division
I876_14740	COG2001	Belongs to the MraZ family
I876_14765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I876_14790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I876_14790	COG0678	peroxiredoxin activity
I876_14805	COG3706	GGDEF domain
I876_14815	COG2204	response regulator
I876_14820	COG2205	protein histidine kinase activity
I876_14820	COG0784	Response regulator, receiver
I876_14850	COG0668	transmembrane transport
I876_14855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I876_14860	COG0189	ligase activity
I876_14865	COG1678	Uncharacterized ACR, COG1678
I876_14870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I876_14895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I876_14900	COG0762	integral membrane protein
I876_14910	COG1902	pentaerythritol trinitrate reductase activity
I876_14910	COG0446	pyridine nucleotide-disulphide oxidoreductase
I876_14925	COG0625	glutathione transferase activity
I876_14935	COG1764	response to oxidative stress
I876_14940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I876_14955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I876_14965	COG2814	Major facilitator Superfamily
I876_14970	COG0724	RNA recognition motif
I876_15000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I876_15005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I876_15010	COG0083	homoserine kinase activity
I876_15025	COG0583	DNA-binding transcription factor activity
I876_15040	COG0640	Transcriptional regulator
I876_15050	COG0431	NADPH-dependent FMN reductase
I876_15055	COG0798	PFAM Bile acid sodium symporter
I876_15060	COG2201	protein-glutamate methylesterase activity
I876_15065	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I876_15075	COG0642	Histidine kinase
I876_15095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I876_15125	COG1748	Saccharopine dehydrogenase
I876_15140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I876_15145	COG3107	peptidoglycan biosynthetic process
I876_15160	COG0438	transferase activity, transferring glycosyl groups
I876_15170	COG2823	Periplasmic or secreted lipoprotein
I876_15190	COG4585	Histidine kinase
I876_15195	COG2197	response regulator
I876_15210	COG4771	TonB-dependent receptor
I876_15220	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I876_15225	COG0372	Belongs to the citrate synthase family
I876_15230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I876_15235	COG2828	Protein conserved in bacteria
I876_15240	COG2203	Gaf domain
I876_15240	COG2199	diguanylate cyclase activity
I876_15245	COG1940	carbohydrate kinase activity
I876_15285	COG0784	Response regulator, receiver
I876_15285	COG2198	Histidine kinase
I876_15285	COG5002	protein histidine kinase activity
I876_15290	COG3023	N-Acetylmuramoyl-L-alanine amidase
I876_15295	COG0069	glutamate synthase activity
I876_15295	COG0067	glutamate synthase
I876_15295	COG0070	glutamate synthase
I876_15300	COG0493	'glutamate synthase
I876_15315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I876_15320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I876_15325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I876_15330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I876_15345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I876_15350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I876_15360	COG4942	peptidase
I876_15365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I876_15370	COG0738	Major facilitator superfamily
I876_15380	COG1902	pentaerythritol trinitrate reductase activity
I876_15400	COG0625	glutathione transferase activity
I876_15425	COG2894	cell division
I876_15430	COG0850	regulation of cytokinetic process
I876_15440	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I876_15470	COG1914	H( )-stimulated, divalent metal cation uptake system
I876_15475	COG0436	Aminotransferase
I876_15495	COG0174	glutamine synthetase
I876_15505	COG3852	Histidine kinase
I876_15510	COG2204	response regulator
I876_15515	COG3437	response regulator, receiver
I876_15520	COG0204	Acyl-transferase
I876_15535	COG3706	GGDEF domain
I876_15555	COG3850	Histidine kinase
I876_15555	COG3437	response regulator, receiver
I876_15555	COG2205	protein histidine kinase activity
I876_15555	COG4999	Histidine kinase
I876_15560	COG0525	valine-tRNA ligase activity
I876_15565	COG2927	DNA polymerase III (CHI subunit)
I876_15570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I876_15575	COG0795	lipopolysaccharide-transporting ATPase activity
I876_15580	COG0795	lipopolysaccharide-transporting ATPase activity
I876_15670	COG3250	beta-galactosidase activity
I876_15680	COG4948	Mandelate Racemase Muconate Lactonizing
I876_15685	COG3661	Belongs to the glycosyl hydrolase 67 family
I876_15700	COG2203	Gaf domain
I876_15700	COG2199	diguanylate cyclase activity
I876_15725	COG0673	inositol 2-dehydrogenase activity
I876_15730	COG0784	Response regulator, receiver
I876_15730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I876_15730	COG2198	Histidine kinase
I876_15730	COG2205	protein histidine kinase activity
I876_15735	COG0628	permease
I876_15750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I876_15755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I876_15760	COG4558	Periplasmic binding protein
I876_15770	COG4206	TonB-dependent receptor
I876_15780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I876_15785	COG0697	spore germination
I876_15815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I876_15835	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I876_15890	COG1131	(ABC) transporter
I876_15900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I876_15910	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I876_15950	COG2205	protein histidine kinase activity
I876_15960	COG0348	domain, Protein
I876_15960	COG3901	Regulator of nitric oxide reductase transcription
I876_15970	COG2197	response regulator
I876_16000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I876_16015	COG4771	TonB-dependent receptor
I876_16025	COG0583	DNA-binding transcription factor activity
I876_16030	COG1304	FMN binding
I876_16035	COG0277	FAD linked oxidase domain protein
I876_16045	COG1462	curli production assembly transport component CsgG
I876_16075	COG2197	response regulator
I876_16085	COG1028	Short-chain dehydrogenase reductase Sdr
I876_16100	COG0513	Belongs to the DEAD box helicase family
I876_16125	COG0800	Aldolase
I876_16130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_16135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_16150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I876_16150	COG3264	Mechanosensitive ion channel
I876_16170	COG0840	transmembrane signaling receptor activity
I876_16195	COG0730	response to heat
I876_16215	COG4191	Histidine kinase
I876_16225	COG0417	DNA replication proofreading
I876_16235	COG0318	PFAM AMP-dependent synthetase and ligase
I876_16255	COG1309	transcriptional regulator
I876_16265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_16275	COG1573	uracil-dna glycosylase
I876_16280	COG3300	MHYT domain
I876_16280	COG5001	Diguanylate cyclase
I876_16300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I876_16320	COG1983	PspC domain protein
I876_16325	COG1842	Phage shock protein A
I876_16335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_16370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I876_16370	COG2885	chlorophyll binding
I876_16375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I876_16385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I876_16390	COG0204	Acyl-transferase
I876_16395	COG0204	Acyl-transferase
I876_16400	COG0668	transmembrane transport
I876_16415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I876_16420	COG0733	neurotransmitter:sodium symporter activity
I876_16435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I876_16450	COG0716	FMN binding
I876_16460	COG0848	biopolymer transport protein
I876_16480	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I876_16495	COG1215	transferase activity, transferring glycosyl groups
I876_16505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I876_16510	COG0702	epimerase
I876_16525	COG5002	protein histidine kinase activity
I876_16525	COG5001	Diguanylate cyclase
I876_16535	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I876_16545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_16555	COG0583	DNA-binding transcription factor activity
I876_16560	COG0121	glutamine amidotransferase
I876_16570	COG4682	membrane
I876_16590	COG1953	Uracil, thiamine, allantoin
I876_16595	COG4771	TonB-dependent receptor
I876_16605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I876_16610	COG0778	Nitroreductase
I876_16615	COG0596	Alpha beta hydrolase
I876_16620	COG0251	oxidation-reduction process
I876_16625	COG1335	isochorismatase
I876_16630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I876_16635	COG1309	transcriptional regulator
I876_16650	COG4628	conserved protein (DUF2132)
I876_16655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I876_16665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I876_16685	COG1477	protein flavinylation
I876_16690	COG2871	sodium ion transport
I876_16695	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_16700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_16705	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_16710	COG1805	sodium ion transport
I876_16715	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I876_16720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I876_16725	COG0545	Peptidyl-prolyl cis-trans isomerase
I876_16730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I876_16745	COG0039	L-malate dehydrogenase activity
I876_16750	COG1438	arginine binding
I876_16775	COG0572	uridine kinase
I876_16780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I876_16800	COG0745	RESPONSE REGULATOR receiver
I876_16800	COG3706	GGDEF domain
I876_16805	COG2176	DNA-directed DNA polymerase activity
I876_16815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I876_16835	COG0189	ligase activity
I876_16845	COG0189	ligase activity
I876_16845	COG4067	protein conserved in archaea
I876_16870	COG1283	sodium-dependent phosphate transmembrane transporter activity
I876_16875	COG0667	Aldo Keto reductase
I876_16905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I876_16915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I876_16945	COG2274	protein secretion by the type I secretion system
I876_16950	COG0583	DNA-binding transcription factor activity
I876_16975	COG1216	Glycosyl transferase, family 2
I876_16975	COG0438	transferase activity, transferring glycosyl groups
I876_16985	COG1091	dTDP-4-dehydrorhamnose reductase activity
I876_16995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I876_17000	COG0457	Tetratricopeptide repeat
I876_17185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I876_17195	COG2161	toxin-antitoxin pair type II binding
I876_17205	COG0202	RNA polymerase activity
I876_17230	COG0201	protein transport
I876_17250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I876_17285	COG0784	Response regulator, receiver
I876_17285	COG5002	protein histidine kinase activity
I876_17310	COG0557	exoribonuclease II activity
I876_17355	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I876_17370	COG0543	2 iron, 2 sulfur cluster binding
I876_17385	COG2234	aminopeptidase activity
I876_17395	COG4251	negative regulation of phosphorylation
I876_17405	COG1271	oxidase subunit
I876_17410	COG1294	oxidase, subunit
I876_17420	COG1522	sequence-specific DNA binding
I876_17430	COG1278	Cold shock
I876_17435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I876_17455	COG0339	signal peptide processing
I876_17460	COG2201	protein-glutamate methylesterase activity
I876_17470	COG3852	Histidine kinase
I876_17480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I876_17485	COG0243	molybdopterin cofactor binding
I876_17490	COG1506	peptidase
I876_17490	COG4946	Tricorn protease homolog
I876_17490	COG0823	Involved in the tonB-independent uptake of proteins
I876_17540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I876_17550	COG2197	response regulator
I876_17560	COG0189	ligase activity
I876_17580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I876_17585	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I876_17590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I876_17605	COG0281	malic enzyme
I876_17615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I876_17645	COG0456	acetyltransferase
I876_17655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I876_17660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I876_17665	COG2177	Part of the ABC transporter FtsEX involved in
I876_17670	COG2884	Cell division ATP-binding protein ftsE
I876_17675	COG0552	protein localization to endoplasmic reticulum
I876_17680	COG0742	ribosomal rna small subunit methyltransferase
I876_17690	COG2095	MarC family integral membrane protein
I876_17710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I876_17715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I876_17720	COG0617	tRNA 3'-terminal CCA addition
I876_17725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I876_17740	COG0076	glutamate decarboxylase activity
I876_17755	COG0842	Transport permease protein
I876_17760	COG1131	(ABC) transporter
I876_17765	COG0745	RESPONSE REGULATOR receiver
I876_17770	COG2205	protein histidine kinase activity
I876_17775	COG4774	siderophore transport
I876_17795	COG1253	flavin adenine dinucleotide binding
I876_17805	COG1966	Carbon starvation protein
I876_17835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I876_17840	COG0049	tRNA binding
I876_17845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I876_17850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I876_17855	COG0085	RNA polymerase activity
I876_17865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I876_17870	COG0081	regulation of translation
I876_17875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I876_17895	COG0250	Participates in transcription elongation, termination and antitermination
I876_17900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I876_17905	COG1132	(ABC) transporter
I876_17910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I876_17915	COG3590	peptidase
I876_17925	COG0513	Belongs to the DEAD box helicase family
I876_17930	COG0418	dihydroorotase activity
I876_17935	COG3040	lipid binding
I876_17940	COG4989	oxidoreductase activity
I876_17945	COG0346	lactoylglutathione lyase activity
I876_17950	COG0668	transmembrane transport
I876_17970	COG0302	gtp cyclohydrolase
I876_17980	COG2957	Belongs to the agmatine deiminase family
I876_17985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I876_17995	COG1201	RNA secondary structure unwinding
I876_18005	COG1793	dna ligase
I876_18010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I876_18015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I876_18030	COG0625	glutathione transferase activity
I876_18035	COG0625	glutathione transferase activity
I876_18045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I876_18060	COG1012	belongs to the aldehyde dehydrogenase family
I876_18065	COG0028	Belongs to the TPP enzyme family
I876_18075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I876_18080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I876_18085	COG0330	HflC and HflK could
I876_18090	COG0330	HflC and HflK could
I876_18095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I876_18100	COG1923	regulation of RNA biosynthetic process
I876_18105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I876_18120	COG0802	atpase or kinase
I876_18125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I876_18125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I876_18130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I876_18140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I876_18150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I876_18155	COG0735	belongs to the Fur family
I876_18165	COG0432	Pfam Uncharacterised protein family UPF0047
I876_18175	COG0305	Participates in initiation and elongation during chromosome replication
I876_18200	COG2258	MOSC domain
I876_18230	COG2198	Histidine kinase
I876_18230	COG2205	protein histidine kinase activity
I876_18230	COG0784	Response regulator, receiver
I876_18240	COG1136	(ABC) transporter
I876_18240	COG0577	efflux transmembrane transporter activity
I876_18250	COG0840	transmembrane signaling receptor activity
I876_18255	COG5002	protein histidine kinase activity
I876_18260	COG0840	transmembrane signaling receptor activity
I876_18290	COG1472	Belongs to the glycosyl hydrolase 3 family
I876_18300	COG2723	6-phospho-beta-galactosidase activity
I876_18305	COG1609	Transcriptional regulator
I876_18310	COG2814	Major facilitator Superfamily
I876_18310	COG0477	Major facilitator Superfamily
I876_18315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I876_18320	COG4988	ABC transporter
I876_18325	COG4890	Cyd operon protein YbgT
I876_18330	COG1294	oxidase, subunit
I876_18345	COG2204	response regulator
I876_18370	COG4319	ketosteroid isomerase
I876_18380	COG3706	GGDEF domain
I876_18390	COG2375	cellular response to nickel ion
I876_18395	COG3237	CsbD-like
I876_18420	COG0596	Alpha beta hydrolase
I876_18420	COG0508	dehydrogenase complex catalyzes the overall conversion of
I876_18440	COG3038	cytochrome b561
I876_18450	COG1252	NADH dehydrogenase
I876_18465	COG0583	DNA-binding transcription factor activity
I876_18470	COG2067	long-chain fatty acid transport protein
I876_18475	COG2130	NADP-dependent
I876_18480	COG4251	negative regulation of phosphorylation
I876_18480	COG2203	Gaf domain
I876_18480	COG5001	Diguanylate cyclase
I876_18480	COG3706	GGDEF domain
I876_18485	COG2205	protein histidine kinase activity
I876_18485	COG0784	Response regulator, receiver
I876_18500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I876_18505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I876_18510	COG1349	DNA-binding transcription factor activity
I876_18515	COG0673	inositol 2-dehydrogenase activity
I876_18530	COG0697	spore germination
I876_18535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I876_18540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I876_18545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I876_18550	COG1166	arginine decarboxylase activity
I876_18560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I876_18565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I876_18570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I876_18615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I876_18620	COG0109	protoheme IX farnesyltransferase activity
I876_18640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I876_18685	COG3030	protein affecting phage T7 exclusion by the F plasmid
I876_18690	COG1324	tolerance protein
I876_18695	COG4232	protein-disulfide reductase activity
I876_18700	COG0739	heme binding
I876_18705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I876_18710	COG0511	ligase activity, forming carbon-carbon bonds
I876_18715	COG0439	Biotin carboxylase
I876_18760	COG0154	amidase activity
I876_18775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I876_18780	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I876_18795	COG0151	Belongs to the GarS family
I876_18810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I876_18815	COG3954	Phosphoribulokinase
I876_18825	COG0745	RESPONSE REGULATOR receiver
I876_18845	COG1501	Belongs to the glycosyl hydrolase 31 family
I876_18855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I876_18865	COG3031	protein transport across the cell outer membrane
I876_18875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I876_18880	COG1459	type II secretion system
I876_18885	COG2165	general secretion pathway protein
I876_18890	COG2165	general secretion pathway protein
I876_18895	COG2165	general secretion pathway protein
I876_18900	COG4795	General secretion pathway protein
I876_18915	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I876_18930	COG1012	belongs to the aldehyde dehydrogenase family
I876_18940	COG1011	Hydrolase
I876_18945	COG0494	nUDIX hydrolase
I876_18950	COG1218	3'(2'),5'-bisphosphate nucleotidase
I876_18965	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I876_18975	COG3089	Belongs to the UPF0270 family
I876_18980	COG0429	hydrolase of the alpha beta-hydrolase fold
I876_18990	COG0488	(ABC) transporter
I876_19010	COG2900	Belongs to the SlyX family
I876_19020	COG0545	Peptidyl-prolyl cis-trans isomerase
I876_19030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I876_19035	COG2183	response to ionizing radiation
I876_19055	COG0596	Alpha beta hydrolase
I876_19060	COG1040	competence protein
I876_19080	COG1794	racemase activity, acting on amino acids and derivatives
I876_19090	COG0534	Mate efflux family protein
I876_19105	COG1999	signal sequence binding
I876_19110	COG0109	protoheme IX farnesyltransferase activity
I876_19115	COG1612	heme a metabolic process
I876_19135	COG1845	cytochrome c oxidase, subunit III
I876_19140	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I876_19145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I876_19150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I876_19160	COG3706	GGDEF domain
I876_19175	COG0129	dihydroxy-acid dehydratase activity
I876_19185	COG0606	chelatase, subunit chli
I876_19190	COG0583	DNA-binding transcription factor activity
I876_19200	COG2814	Major facilitator Superfamily
I876_19210	COG0729	surface antigen
I876_19215	COG2911	Protein conserved in bacteria
I876_19240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I876_19250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I876_19270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I876_19290	COG1228	amidohydrolase
I876_19315	COG0425	Belongs to the sulfur carrier protein TusA family
I876_19335	COG1561	YicC-like family, N-terminal region
I876_19345	COG3550	peptidyl-serine autophosphorylation
I876_19350	COG3620	sequence-specific DNA binding
I876_19450	COG3177	Filamentation induced by cAMP protein fic
I876_19460	COG1609	Transcriptional regulator
I876_19475	COG2199	diguanylate cyclase activity
I876_19475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I876_19505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I876_19525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I876_19530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I876_19550	COG1475	DNA binding
I876_19555	COG1192	Involved in chromosome partitioning
I876_19580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I876_19595	COG0706	membrane insertase activity
I876_19600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I876_19605	COG0594	ribonuclease P activity
I876_19610	COG0230	Belongs to the bacterial ribosomal protein bL34 family