locus-tag	class	description
I634_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I634_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I634_00020	COG0187	DNA topoisomerase II activity
I634_00040	COG2818	Glycosylase
I634_00050	COG3078	GTPase activator activity
I634_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I634_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I634_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I634_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I634_00085	COG0569	domain protein
I634_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I634_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I634_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I634_00110	COG0758	DNA mediated transformation
I634_00125	COG0009	L-threonylcarbamoyladenylate synthase
I634_00130	COG0408	coproporphyrinogen oxidase activity
I634_00135	COG3047	cAMP biosynthetic process
I634_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I634_00205	COG2234	aminopeptidase activity
I634_00210	COG0463	Glycosyl transferase, family 2
I634_00220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I634_00245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_00275	COG3642	lipopolysaccharide core region biosynthetic process
I634_00280	COG0859	PFAM glycosyl transferase family 9
I634_00310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_00325	COG3161	chorismate lyase activity
I634_00330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I634_00350	COG0210	DNA helicase
I634_00395	COG1959	2 iron, 2 sulfur cluster binding
I634_00400	COG0730	response to heat
I634_00415	COG4771	TonB-dependent receptor
I634_00435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I634_00440	COG4988	ABC transporter
I634_00450	COG1271	oxidase subunit
I634_00460	COG0425	Belongs to the sulfur carrier protein TusA family
I634_00460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_00470	COG0450	alkyl hydroperoxide reductase
I634_00480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I634_00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_00540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_00545	COG1129	ABC transporter
I634_00545	COG0842	Transport permease protein
I634_00550	COG0842	Transport permease protein
I634_00565	COG1960	acyl-CoA dehydrogenase activity
I634_00570	COG0583	DNA-binding transcription factor activity
I634_00580	COG3106	COG3106 Predicted ATPase
I634_00595	COG2184	nucleotidyltransferase activity
I634_00600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I634_00620	COG0352	thiamine-phosphate diphosphorylase activity
I634_00630	COG3071	HemY protein
I634_00635	COG2959	enzyme of heme biosynthesis
I634_00645	COG0181	hydroxymethylbilane synthase activity
I634_00650	COG3706	GGDEF domain
I634_00665	COG0194	GDP metabolic process
I634_00675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I634_00685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I634_00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I634_00700	COG0678	peroxiredoxin activity
I634_00715	COG1178	ABC-type Fe3 transport system permease component
I634_00720	COG3842	ATPase activity
I634_00725	COG0668	transmembrane transport
I634_00730	COG2081	HI0933 family
I634_00745	COG2963	transposase activity
I634_00760	COG4772	TonB-dependent receptor
I634_00795	COG1230	cation diffusion facilitator family transporter
I634_00870	COG0789	Transcriptional regulator
I634_00875	COG2963	transposase activity
I634_00880	COG2801	Transposase and inactivated derivatives
I634_00895	COG2200	EAL domain
I634_00900	COG0583	DNA-binding transcription factor activity
I634_00910	COG2076	Multidrug Resistance protein
I634_00925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_00940	COG0427	acetyl-CoA hydrolase
I634_00945	COG0123	including yeast histone deacetylase and acetoin utilization protein
I634_00960	COG0840	transmembrane signaling receptor activity
I634_00970	COG3064	Membrane
I634_00980	COG5001	Diguanylate cyclase
I634_00980	COG5002	protein histidine kinase activity
I634_00995	COG0514	ATP-dependent DNA helicase (RecQ)
I634_01000	COG2239	Acts as a magnesium transporter
I634_01005	COG2962	Rard protein
I634_01010	COG3706	GGDEF domain
I634_01010	COG0745	RESPONSE REGULATOR receiver
I634_01015	COG0210	DNA helicase
I634_01025	COG1011	Hydrolase
I634_01040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I634_01045	COG0019	diaminopimelate decarboxylase activity
I634_01075	COG0163	prenyltransferase activity
I634_01080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I634_01095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I634_01115	COG1077	Cell shape determining protein MreB Mrl
I634_01125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I634_01130	COG2814	Major facilitator Superfamily
I634_01135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_01165	COG1085	galactose-1-phosphate uridylyltransferase
I634_01170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I634_01180	COG0629	single-stranded DNA binding
I634_01195	COG3250	beta-galactosidase activity
I634_01220	COG1349	DNA-binding transcription factor activity
I634_01265	COG3409	Peptidoglycan-binding domain 1 protein
I634_01265	COG3267	Type II secretory pathway component ExeA
I634_01275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I634_01280	COG1459	type II secretion system
I634_01325	COG1077	Cell shape determining protein MreB Mrl
I634_01330	COG1792	Involved in formation and maintenance of cell shape
I634_01335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I634_01345	COG1530	ribonuclease E activity
I634_01355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_01360	COG0312	modulator of DNA gyrase
I634_01365	COG3028	Belongs to the UPF0307 family
I634_01370	COG0312	modulator of DNA gyrase
I634_01385	COG0745	RESPONSE REGULATOR receiver
I634_01390	COG4191	Histidine kinase
I634_01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_01395	COG0297	glycogen (starch) synthase activity
I634_01405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I634_01410	COG0596	Alpha beta hydrolase
I634_01455	COG5310	Homospermidine synthase
I634_01480	COG3251	PFAM MbtH domain protein
I634_01585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I634_01590	COG5002	protein histidine kinase activity
I634_01595	COG0745	RESPONSE REGULATOR receiver
I634_01620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_01720	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I634_01750	COG0375	protein maturation
I634_01760	COG0409	Hydrogenase expression formation protein
I634_01770	COG0309	Hydrogenase expression formation protein (HypE)
I634_01775	COG0789	Transcriptional regulator
I634_01780	COG2217	Heavy metal translocating P-type atpase
I634_01865	COG0531	amino acid
I634_01875	COG2132	Multicopper oxidase
I634_01945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I634_01965	COG0835	chemotaxis
I634_01975	COG0745	RESPONSE REGULATOR receiver
I634_01990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I634_02005	COG0835	chemotaxis
I634_02015	COG0745	RESPONSE REGULATOR receiver
I634_02030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I634_02040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I634_02050	COG0463	Glycosyl transferase, family 2
I634_02055	COG0745	RESPONSE REGULATOR receiver
I634_02060	COG5002	protein histidine kinase activity
I634_02120	COG0546	phosphoglycolate phosphatase activity
I634_02145	COG1609	Transcriptional regulator
I634_02150	COG0673	inositol 2-dehydrogenase activity
I634_02160	COG2211	Major facilitator Superfamily
I634_02185	COG1454	alcohol dehydrogenase
I634_02235	COG0089	rRNA binding
I634_02245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I634_02255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I634_02270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I634_02275	COG0438	transferase activity, transferring glycosyl groups
I634_02285	COG1519	Transferase
I634_02305	COG0840	transmembrane signaling receptor activity
I634_02320	COG0788	formyltetrahydrofolate deformylase activity
I634_02330	COG1643	Atp-dependent helicase
I634_02335	COG2951	lytic endotransglycosylase activity
I634_02340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I634_02355	COG2354	Protein conserved in bacteria
I634_02360	COG4977	sequence-specific DNA binding
I634_02375	COG0004	ammonium transporteR
I634_02380	COG0405	Gamma-glutamyltransferase
I634_02385	COG2837	iron assimilation
I634_02400	COG0540	Belongs to the ATCase OTCase family
I634_02425	COG5002	protein histidine kinase activity
I634_02425	COG2205	protein histidine kinase activity
I634_02425	COG0784	Response regulator, receiver
I634_02455	COG1012	belongs to the aldehyde dehydrogenase family
I634_02465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I634_02480	COG0180	Tryptophanyl-tRNA synthetase
I634_02485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I634_02505	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I634_02515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I634_02550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I634_02555	COG0281	malic enzyme
I634_02570	COG0625	glutathione transferase activity
I634_02580	COG0753	catalase activity
I634_02595	COG3300	MHYT domain
I634_02595	COG5001	Diguanylate cyclase
I634_02600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I634_02600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I634_02610	COG0137	argininosuccinate synthase activity
I634_02630	COG1803	Methylglyoxal synthase
I634_02640	COG0745	RESPONSE REGULATOR receiver
I634_02645	COG2205	protein histidine kinase activity
I634_02650	COG2267	carboxylic ester hydrolase activity
I634_02655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I634_02665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I634_02675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I634_02680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_02685	COG4942	peptidase
I634_02690	COG2861	carbohydrate metabolic process
I634_02715	COG1162	GTPase activity
I634_02720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I634_02740	COG0028	Belongs to the TPP enzyme family
I634_02760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I634_02765	COG0805	protein transport
I634_02775	COG0084	hydrolase, TatD family'
I634_02780	COG4251	negative regulation of phosphorylation
I634_02780	COG3706	GGDEF domain
I634_02780	COG2203	Gaf domain
I634_02780	COG5001	Diguanylate cyclase
I634_02790	COG0248	Ppx GppA phosphatase
I634_02795	COG0513	Belongs to the DEAD box helicase family
I634_02800	COG3118	belongs to the thioredoxin family
I634_02805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I634_02815	COG0784	Response regulator, receiver
I634_02815	COG5002	protein histidine kinase activity
I634_02820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I634_02830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I634_02835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I634_02860	COG0783	Belongs to the Dps family
I634_02865	COG2133	pyrroloquinoline quinone binding
I634_02870	COG1506	peptidase
I634_02870	COG0823	Involved in the tonB-independent uptake of proteins
I634_02870	COG4946	Tricorn protease homolog
I634_02880	COG3118	belongs to the thioredoxin family
I634_02895	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I634_02905	COG1012	belongs to the aldehyde dehydrogenase family
I634_02925	COG1757	Na H antiporter
I634_02940	COG3876	Protein conserved in bacteria
I634_02945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I634_02955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I634_02965	COG0346	lactoylglutathione lyase activity
I634_02990	COG2824	Alkylphosphonate utilization operon protein PhnA
I634_02995	COG0454	-acetyltransferase
I634_03020	COG3093	addiction module antidote protein HigA
I634_03035	COG2026	Addiction module toxin, RelE StbE family
I634_03075	COG1733	regulation of RNA biosynthetic process
I634_03120	COG3550	peptidyl-serine autophosphorylation
I634_03135	COG0183	Belongs to the thiolase family
I634_03140	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_03140	COG1024	Enoyl-CoA hydratase
I634_03150	COG0006	proline dipeptidase activity
I634_03160	COG0142	geranyltranstransferase activity
I634_03190	COG1388	LysM domain
I634_03190	COG4942	peptidase
I634_03195	COG1238	metal cluster binding
I634_03205	COG0585	pseudouridine synthase activity
I634_03210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I634_03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I634_03230	COG0840	transmembrane signaling receptor activity
I634_03270	COG0494	nUDIX hydrolase
I634_03275	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I634_03280	COG0730	response to heat
I634_03285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I634_03290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I634_03300	COG0745	RESPONSE REGULATOR receiver
I634_03300	COG3706	GGDEF domain
I634_03325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I634_03340	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I634_03350	COG1648	precorrin-2 dehydrogenase activity
I634_03350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I634_03355	COG0513	Belongs to the DEAD box helicase family
I634_03375	COG1538	Outer membrane efflux protein
I634_03380	COG0494	nUDIX hydrolase
I634_03390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I634_03395	COG3150	esterase
I634_03400	COG0187	DNA topoisomerase II activity
I634_03410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_03435	COG1509	lysine 2,3-aminomutase activity
I634_03445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I634_03460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I634_03475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I634_03490	COG0271	Belongs to the BolA IbaG family
I634_03505	COG3707	response regulator
I634_03520	COG0659	secondary active sulfate transmembrane transporter activity
I634_03525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I634_03535	COG0243	molybdopterin cofactor binding
I634_03540	COG1648	precorrin-2 dehydrogenase activity
I634_03540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I634_03545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I634_03555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I634_03555	COG1116	anion transmembrane transporter activity
I634_03565	COG1116	anion transmembrane transporter activity
I634_03580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I634_03585	COG4206	TonB-dependent receptor
I634_03595	COG0348	domain, Protein
I634_03610	COG1960	acyl-CoA dehydrogenase activity
I634_03615	COG1028	Short-chain dehydrogenase reductase Sdr
I634_03625	COG4948	Mandelate Racemase Muconate Lactonizing
I634_03640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_03645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_03665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I634_03670	COG0358	DNA primase activity
I634_03690	COG1253	flavin adenine dinucleotide binding
I634_03700	COG1966	Carbon starvation protein
I634_03745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I634_03750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I634_03765	COG0537	adenosine 5'-monophosphoramidase activity
I634_03780	COG3135	benzoate transporter
I634_03785	COG1396	sequence-specific DNA binding
I634_03790	COG2974	May be involved in recombination
I634_03795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_03795	COG4191	Histidine kinase
I634_03800	COG0745	RESPONSE REGULATOR receiver
I634_03805	COG5002	protein histidine kinase activity
I634_03835	COG0811	peptide transport
I634_03840	COG0811	peptide transport
I634_03845	COG0848	biopolymer transport protein
I634_03850	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I634_03860	COG3437	response regulator, receiver
I634_03870	COG0318	PFAM AMP-dependent synthetase and ligase
I634_03880	COG2133	pyrroloquinoline quinone binding
I634_03890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I634_03895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_03920	COG0527	aspartate kinase activity
I634_03930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I634_03935	COG2967	ApaG domain
I634_03945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I634_03950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_03955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I634_03960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I634_03970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I634_03990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I634_04010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I634_04015	COG3956	TIGRFAM MazG family protein
I634_04040	COG1028	Short-chain dehydrogenase reductase Sdr
I634_04050	COG0318	PFAM AMP-dependent synthetase and ligase
I634_04060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I634_04070	COG0463	Glycosyl transferase, family 2
I634_04090	COG0642	Histidine kinase
I634_04095	COG0745	RESPONSE REGULATOR receiver
I634_04110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I634_04115	COG0723	plastoquinol--plastocyanin reductase activity
I634_04120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I634_04125	COG2857	Cytochrome c1
I634_04130	COG0625	glutathione transferase activity
I634_04135	COG2969	positive regulation of protein catabolic process
I634_04140	COG2239	Acts as a magnesium transporter
I634_04145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I634_04155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I634_04165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I634_04170	COG1137	ATPase activity
I634_04175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I634_04185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I634_04200	COG1127	ABC transporter
I634_04205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I634_04210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I634_04215	COG2854	intermembrane phospholipid transfer
I634_04225	COG5007	Belongs to the BolA IbaG family
I634_04235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I634_04240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I634_04250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I634_04285	COG4771	TonB-dependent receptor
I634_04290	COG0697	spore germination
I634_04300	COG2205	protein histidine kinase activity
I634_04300	COG0784	Response regulator, receiver
I634_04325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I634_04335	COG0126	phosphoglycerate kinase activity
I634_04340	COG3588	fructose-bisphosphate aldolase
I634_04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_04365	COG1538	Outer membrane efflux protein
I634_04370	COG0823	Involved in the tonB-independent uptake of proteins
I634_04370	COG1506	peptidase
I634_04370	COG4946	Tricorn protease homolog
I634_04375	COG0248	Ppx GppA phosphatase
I634_04380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I634_04390	COG0573	inorganic phosphate transmembrane transporter activity
I634_04400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I634_04410	COG0306	phosphate transporter
I634_04420	COG0583	DNA-binding transcription factor activity
I634_04430	COG1272	protein, Hemolysin III
I634_04435	COG1846	Transcriptional regulator
I634_04440	COG1764	response to oxidative stress
I634_04455	COG1739	Uncharacterized protein family UPF0029
I634_04465	COG0420	3'-5' exonuclease activity
I634_04470	COG0419	ATPase involved in DNA repair
I634_04480	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I634_04505	COG2986	histidine ammonia-lyase
I634_04535	COG0488	(ABC) transporter
I634_04560	COG0668	transmembrane transport
I634_04640	COG1346	cytolysis
I634_04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I634_04680	COG0513	Belongs to the DEAD box helicase family
I634_04690	COG3409	Peptidoglycan-binding domain 1 protein
I634_04690	COG3267	Type II secretory pathway component ExeA
I634_04705	COG0066	3-isopropylmalate dehydratase activity
I634_04715	COG0473	3-isopropylmalate dehydrogenase activity
I634_04720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I634_04740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I634_04755	COG4555	ABC transporter
I634_04760	COG1668	transmembrane transport
I634_04775	COG4133	protoheme IX ABC transporter activity
I634_04780	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_04785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_04790	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I634_04800	COG1138	Cytochrome C-type biogenesis protein
I634_04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I634_04820	COG2853	Lipoprotein
I634_04825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I634_04835	COG3104	oligopeptide transport
I634_04865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I634_04880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I634_04885	COG1555	photosystem II stabilization
I634_04885	COG1596	polysaccharide export
I634_04890	COG0473	3-isopropylmalate dehydrogenase activity
I634_04905	COG1611	Belongs to the LOG family
I634_04910	COG0745	RESPONSE REGULATOR receiver
I634_04910	COG3706	GGDEF domain
I634_04915	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I634_04915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I634_04970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I634_04975	COG0024	Methionine aminopeptidase
I634_04980	COG0052	Belongs to the universal ribosomal protein uS2 family
I634_04990	COG0528	UMP kinase activity
I634_05000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I634_05005	COG0575	Belongs to the CDS family
I634_05030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I634_05050	COG0587	DNA-directed DNA polymerase activity
I634_05055	COG0825	malonyl-CoA metabolic process
I634_05060	COG0037	tRNA processing
I634_05080	COG0590	tRNA wobble adenosine to inosine editing
I634_05095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I634_05095	COG0047	phosphoribosylformylglycinamidine synthase activity
I634_05105	COG2840	Smr protein MutS2
I634_05160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_05165	COG2197	response regulator
I634_05205	COG0835	chemotaxis
I634_05205	COG0784	Response regulator, receiver
I634_05210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I634_05215	COG1815	bacterial-type flagellum-dependent cell motility
I634_05220	COG1558	bacterial-type flagellum-dependent cell motility
I634_05225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I634_05230	COG1749	Flagellar hook protein flgE
I634_05235	COG4787	bacterial-type flagellum-dependent cell motility
I634_05240	COG4786	Flagellar basal body rod
I634_05255	COG3951	Flagellar rod assembly protein muramidase FlgJ
I634_05255	COG1705	Flagellar rod assembly protein muramidase FlgJ
I634_05260	COG1256	bacterial-type flagellum assembly
I634_05290	COG1334	flagellar protein FlaG
I634_05295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I634_05325	COG2089	acid synthase
I634_05330	COG3980	spore coat polysaccharide biosynthesis protein
I634_05335	COG1083	cytidylyl-transferase
I634_05340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I634_05345	COG1086	Polysaccharide biosynthesis protein
I634_05355	COG2204	response regulator
I634_05360	COG3852	Histidine kinase
I634_05365	COG2204	response regulator
I634_05370	COG1677	Flagellar hook-basal body complex protein FliE
I634_05375	COG1766	The M ring may be actively involved in energy transduction
I634_05380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I634_05430	COG1987	bacterial-type flagellum assembly
I634_05445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I634_05455	COG0455	bacterial-type flagellum organization
I634_05470	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I634_05475	COG0643	Histidine kinase
I634_05475	COG2198	Histidine kinase
I634_05485	COG1192	Involved in chromosome partitioning
I634_05495	COG0835	chemotaxis
I634_05510	COG0646	methionine synthase
I634_05510	COG1410	methionine synthase
I634_05515	COG0646	methionine synthase
I634_05515	COG1410	methionine synthase
I634_05525	COG3123	guanosine phosphorylase activity
I634_05530	COG0583	DNA-binding transcription factor activity
I634_05535	COG0583	DNA-binding transcription factor activity
I634_05545	COG0659	secondary active sulfate transmembrane transporter activity
I634_05560	COG3590	peptidase
I634_05570	COG2137	regulation of response to DNA damage stimulus
I634_05575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I634_05595	COG0511	ligase activity, forming carbon-carbon bonds
I634_05595	COG5016	pyruvate
I634_05600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I634_05605	COG4172	Belongs to the ABC transporter superfamily
I634_05615	COG4171	peptide transport system, permease
I634_05620	COG4168	peptide transport system, permease
I634_05625	COG0747	negative chemotaxis
I634_05630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I634_05635	COG1842	Phage shock protein A
I634_05665	COG0625	glutathione transferase activity
I634_05670	COG1522	sequence-specific DNA binding
I634_05735	COG0811	peptide transport
I634_05740	COG0811	peptide transport
I634_05745	COG0848	biopolymer transport protein
I634_05760	COG1444	tRNA N-acetyltransferase activity
I634_05790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I634_05795	COG0250	Participates in transcription elongation, termination and antitermination
I634_05805	COG0456	acetyltransferase
I634_05815	COG0583	DNA-binding transcription factor activity
I634_05820	COG2814	Major facilitator Superfamily
I634_05830	COG0656	L-ascorbic acid biosynthetic process
I634_05845	COG1846	Transcriptional regulator
I634_05890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I634_05900	COG3706	GGDEF domain
I634_05925	COG0543	2 iron, 2 sulfur cluster binding
I634_05925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I634_05935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I634_05940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I634_05945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I634_05950	COG0564	pseudouridine synthase activity
I634_05960	COG0612	Peptidase, M16
I634_05965	COG2918	glutathione biosynthetic process
I634_05990	COG2840	Smr protein MutS2
I634_05995	COG2890	protein-(glutamine-N5) methyltransferase activity
I634_06010	COG2719	SpoVR family
I634_06015	COG2718	Belongs to the UPF0229 family
I634_06020	COG2766	serine protein kinase
I634_06030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I634_06035	COG4771	TonB-dependent receptor
I634_06060	COG0450	alkyl hydroperoxide reductase
I634_06065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I634_06070	COG2885	chlorophyll binding
I634_06075	COG0584	glycerophosphoryl diester phosphodiesterase
I634_06080	COG0346	lactoylglutathione lyase activity
I634_06085	COG1278	Cold shock
I634_06100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I634_06105	COG4660	Part of a membrane complex involved in electron transport
I634_06110	COG4659	FMN binding
I634_06115	COG4658	electron transport chain
I634_06120	COG4656	Part of a membrane complex involved in electron transport
I634_06125	COG2878	Part of a membrane complex involved in electron transport
I634_06135	COG0534	Mate efflux family protein
I634_06140	COG0556	nucleotide-excision repair
I634_06155	COG0602	queuosine metabolic process
I634_06165	COG0367	asparagine synthase
I634_06190	COG3273	potassium ion transport
I634_06190	COG0471	metal ion transport
I634_06205	COG0529	Catalyzes the synthesis of activated sulfate
I634_06210	COG0175	sulfate reduction
I634_06215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_06220	COG3706	GGDEF domain
I634_06245	COG2304	oxidoreductase activity
I634_06265	COG0714	Associated with various cellular activities
I634_06275	COG1024	Enoyl-CoA hydratase
I634_06275	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_06300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I634_06320	COG0402	S-adenosylhomocysteine deaminase activity
I634_06325	COG1228	amidohydrolase
I634_06330	COG2188	Transcriptional regulator
I634_06335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I634_06380	COG1025	Belongs to the peptidase M16 family
I634_06385	COG2062	phosphohistidine phosphatase, SixA
I634_06395	COG4536	flavin adenine dinucleotide binding
I634_06400	COG4137	Cytochrome C assembly protein
I634_06405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I634_06460	COG1132	(ABC) transporter
I634_06475	COG0228	four-way junction DNA binding
I634_06480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I634_06485	COG0336	Belongs to the RNA methyltransferase TrmD family
I634_06490	COG0335	large ribosomal subunit rRNA binding
I634_06495	COG2860	membrane
I634_06505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I634_06510	COG0287	Prephenate dehydrogenase
I634_06510	COG1605	Chorismate mutase
I634_06515	COG0077	Prephenate dehydratase
I634_06515	COG1605	Chorismate mutase
I634_06525	COG0023	Translation Initiation Factor
I634_06555	COG2205	protein histidine kinase activity
I634_06565	COG2204	response regulator
I634_06585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I634_06590	COG0494	nUDIX hydrolase
I634_06595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I634_06605	COG2255	four-way junction helicase activity
I634_06610	COG0824	Thioesterase
I634_06615	COG0811	peptide transport
I634_06630	COG0823	Involved in the tonB-independent uptake of proteins
I634_06635	COG2885	chlorophyll binding
I634_06640	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I634_06645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I634_06655	COG4667	esterase of the alpha-beta hydrolase superfamily
I634_06660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I634_06675	COG1028	Short-chain dehydrogenase reductase Sdr
I634_06680	COG3038	cytochrome b561
I634_06710	COG1451	nucleotide metabolic process
I634_06720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_06730	COG1309	transcriptional regulator
I634_06735	COG4774	siderophore transport
I634_06755	COG3706	GGDEF domain
I634_06765	COG3008	intermembrane lipid transfer
I634_06765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I634_06770	COG2995	paraquat-inducible protein a
I634_06785	COG0017	Asparaginyl-tRNA synthetase
I634_06800	COG0189	ligase activity
I634_06830	COG0156	8-amino-7-oxononanoate synthase activity
I634_06835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_06845	COG3340	Belongs to the peptidase S51 family
I634_06850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I634_06855	COG4139	cobalamin transport
I634_06860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I634_06865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I634_06880	COG5265	(ABC) transporter
I634_06885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I634_06895	COG0745	RESPONSE REGULATOR receiver
I634_06900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I634_06920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_06935	COG2755	lipolytic protein G-D-S-L family
I634_06940	COG4181	ATPase activity
I634_06945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I634_06950	COG1090	epimerase
I634_06955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I634_06960	COG0628	permease
I634_06970	COG0745	RESPONSE REGULATOR receiver
I634_06985	COG2350	Protein conserved in bacteria
I634_06990	COG0159	tryptophan synthase activity
I634_07000	COG0134	indole-3-glycerol-phosphate synthase activity
I634_07000	COG0135	phosphoribosylanthranilate isomerase activity
I634_07005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I634_07015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I634_07020	COG0613	PHP domain protein
I634_07025	COG0009	L-threonylcarbamoyladenylate synthase
I634_07030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I634_07035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I634_07045	COG0656	L-ascorbic acid biosynthetic process
I634_07050	COG0110	maltose O-acetyltransferase activity
I634_07060	COG2733	membrane
I634_07065	COG0500	methyltransferase
I634_07070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_07075	COG0497	DNA recombination
I634_07080	COG0783	Belongs to the Dps family
I634_07090	COG1454	alcohol dehydrogenase
I634_07095	COG1028	Short-chain dehydrogenase reductase Sdr
I634_07105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I634_07110	COG2610	gluconate transmembrane transporter activity
I634_07125	COG2205	protein histidine kinase activity
I634_07125	COG2198	Histidine kinase
I634_07125	COG0784	Response regulator, receiver
I634_07130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I634_07140	COG0484	heat shock protein binding
I634_07145	COG3909	cytochrome
I634_07150	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I634_07165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I634_07170	COG0505	Belongs to the CarA family
I634_07175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I634_07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I634_07200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I634_07205	COG0280	phosphate acetyltransferase
I634_07205	COG0857	belongs to the CobB CobQ family
I634_07220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I634_07225	COG4535	Mg2 and Co2 transporter CorC
I634_07235	COG1702	phosphate starvation-inducible protein PhoH
I634_07245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_07285	COG1607	acyl-coa hydrolase
I634_07290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I634_07300	COG1115	amino acid carrier protein
I634_07305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I634_07310	COG0012	GTP binding
I634_07325	COG1064	alcohol dehydrogenase
I634_07340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I634_07345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I634_07350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I634_07355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I634_07365	COG2890	protein-(glutamine-N5) methyltransferase activity
I634_07370	COG3437	response regulator, receiver
I634_07370	COG0784	Response regulator, receiver
I634_07380	COG3094	Invasion gene expression up-regulator, SirB
I634_07395	COG0583	DNA-binding transcription factor activity
I634_07405	COG2363	Small membrane protein
I634_07425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I634_07430	COG0515	serine threonine protein kinase
I634_07435	COG2116	formate transmembrane transporter activity
I634_07450	COG0714	Associated with various cellular activities
I634_07455	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I634_07460	COG0033	Phosphoglucomutase
I634_07465	COG0058	SHG alpha-glucan phosphorylase activity
I634_07475	COG2988	succinylglutamate desuccinylase activity
I634_07510	COG1393	Belongs to the ArsC family
I634_07540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I634_07610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I634_07610	COG0475	glutathione-regulated potassium exporter activity
I634_07625	COG1733	regulation of RNA biosynthetic process
I634_07630	COG5001	Diguanylate cyclase
I634_07630	COG5002	protein histidine kinase activity
I634_07630	COG3447	MASE1 domain protein
I634_07640	COG0402	S-adenosylhomocysteine deaminase activity
I634_07645	COG2351	hydroxyisourate hydrolase activity
I634_07660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_07675	COG1309	transcriptional regulator
I634_07690	COG2252	PERMEase
I634_07695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I634_07710	COG2203	Gaf domain
I634_07710	COG3706	GGDEF domain
I634_07710	COG4251	negative regulation of phosphorylation
I634_07710	COG5001	Diguanylate cyclase
I634_07715	COG4251	negative regulation of phosphorylation
I634_07715	COG3706	GGDEF domain
I634_07715	COG2203	Gaf domain
I634_07715	COG5001	Diguanylate cyclase
I634_07720	COG2205	protein histidine kinase activity
I634_07720	COG0784	Response regulator, receiver
I634_07735	COG2233	PERMEase
I634_07750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I634_07755	COG0730	response to heat
I634_07800	COG1028	Short-chain dehydrogenase reductase Sdr
I634_07815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I634_07835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I634_07845	COG1596	polysaccharide export
I634_07850	COG0489	protein tyrosine kinase activity
I634_07855	COG4464	protein tyrosine phosphatase activity
I634_07880	COG3300	MHYT domain
I634_07880	COG5001	Diguanylate cyclase
I634_07890	COG0297	glycogen (starch) synthase activity
I634_07905	COG1215	transferase activity, transferring glycosyl groups
I634_07910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I634_07915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I634_07940	COG0297	glycogen (starch) synthase activity
I634_07955	COG0072	phenylalanine-tRNA ligase activity
I634_07955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_07970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I634_07980	COG1472	Belongs to the glycosyl hydrolase 3 family
I634_07985	COG2096	Adenosyltransferase
I634_07995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I634_08005	COG4591	ABC-type transport system involved in lipoprotein release permease component
I634_08030	COG0708	Exodeoxyribonuclease III
I634_08065	COG2814	Major facilitator Superfamily
I634_08110	COG1024	Enoyl-CoA hydratase
I634_08115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I634_08120	COG1960	acyl-CoA dehydrogenase activity
I634_08125	COG0789	Transcriptional regulator
I634_08130	COG0183	Belongs to the thiolase family
I634_08145	COG3706	GGDEF domain
I634_08155	COG2925	Exonuclease
I634_08210	COG1643	Atp-dependent helicase
I634_08230	COG3321	synthase
I634_08230	COG0604	alcohol dehydrogenase
I634_08235	COG0328	RNA-DNA hybrid ribonuclease activity
I634_08240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I634_08250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I634_08260	COG4591	ABC-type transport system involved in lipoprotein release permease component
I634_08265	COG1301	dicarboxylic acid transport
I634_08275	COG3724	N-succinylarginine dihydrolase activity
I634_08285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I634_08310	COG0746	molybdenum cofactor guanylyltransferase activity
I634_08315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I634_08320	COG0243	molybdopterin cofactor binding
I634_08325	COG2153	protein acetylation
I634_08340	COG1530	ribonuclease E activity
I634_08355	COG0424	maF-like protein
I634_08360	COG1399	metal-binding, possibly nucleic acid-binding protein
I634_08370	COG0416	fatty acid biosynthetic process
I634_08375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I634_08380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I634_08390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I634_08395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I634_08405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I634_08420	COG0084	hydrolase, TatD family'
I634_08430	COG0702	epimerase
I634_08435	COG3706	GGDEF domain
I634_08455	COG1028	Short-chain dehydrogenase reductase Sdr
I634_08460	COG0596	Alpha beta hydrolase
I634_08470	COG0183	Belongs to the thiolase family
I634_08475	COG1960	acyl-CoA dehydrogenase activity
I634_08495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I634_08505	COG0246	Mannitol dehydrogenase
I634_08530	COG0668	transmembrane transport
I634_08535	COG4771	TonB-dependent receptor
I634_08545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_08545	COG2205	protein histidine kinase activity
I634_08550	COG3437	response regulator, receiver
I634_08560	COG0195	Participates in both transcription termination and antitermination
I634_08575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I634_08590	COG1187	pseudouridine synthase activity
I634_08600	COG3153	acetyltransferase
I634_08600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_08640	COG0450	alkyl hydroperoxide reductase
I634_08685	COG1032	radical SAM domain protein
I634_08700	COG4771	TonB-dependent receptor
I634_08705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_08715	COG4134	Bacterial extracellular solute-binding protein
I634_08725	COG4136	ATPase activity
I634_08730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I634_08750	COG5001	Diguanylate cyclase
I634_08750	COG4251	negative regulation of phosphorylation
I634_08750	COG2203	Gaf domain
I634_08750	COG3706	GGDEF domain
I634_08780	COG1902	pentaerythritol trinitrate reductase activity
I634_08790	COG2867	negative regulation of translational initiation
I634_08795	COG2914	Belongs to the UPF0125 (RnfH) family
I634_08805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_08810	COG4771	TonB-dependent receptor
I634_08815	COG0457	Tetratricopeptide repeat
I634_08830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I634_08830	COG0574	Belongs to the PEP-utilizing enzyme family
I634_08870	COG2850	peptidyl-arginine hydroxylation
I634_08880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I634_08885	COG2915	High frequency lysogenization protein hflD homolog
I634_08890	COG0482	sulfurtransferase activity
I634_08895	COG1187	pseudouridine synthase activity
I634_08905	COG1278	Cold shock
I634_08910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I634_08915	COG0542	response to heat
I634_08920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I634_08925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I634_08930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I634_08935	COG0492	ferredoxin-NADP+ reductase activity
I634_08940	COG3092	negative regulation of chromosome organization
I634_08945	COG3091	SprT-like family
I634_08950	COG0616	signal peptide processing
I634_08965	COG0778	Nitroreductase
I634_08975	COG0252	asparaginase activity
I634_08980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I634_08985	COG0321	lipoyl(octanoyl) transferase activity
I634_08990	COG2921	Belongs to the UPF0250 family
I634_08995	COG1686	Belongs to the peptidase S11 family
I634_09000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I634_09005	COG0772	Belongs to the SEDS family
I634_09010	COG0768	penicillin binding
I634_09015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I634_09020	COG0799	negative regulation of ribosome biogenesis
I634_09025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I634_09030	COG1466	dna polymerase III delta subunit
I634_09035	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I634_09040	COG0495	leucyl-tRNA aminoacylation
I634_09055	COG1067	ATP-dependent peptidase activity
I634_09060	COG0596	Alpha beta hydrolase
I634_09065	COG3706	GGDEF domain
I634_09075	COG1534	Rna-binding protein
I634_09080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I634_09085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I634_09090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I634_09095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I634_09100	COG0149	triose-phosphate isomerase activity
I634_09105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I634_09110	COG3300	MHYT domain
I634_09110	COG5001	Diguanylate cyclase
I634_09130	COG1597	lipid kinase activity
I634_09130	COG1803	Methylglyoxal synthase
I634_09140	COG1028	Short-chain dehydrogenase reductase Sdr
I634_09145	COG0561	phosphatase activity
I634_09160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_09185	COG1185	polyribonucleotide nucleotidyltransferase activity
I634_09310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I634_09310	COG2755	lipolytic protein G-D-S-L family
I634_09460	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I634_09465	COG1196	nuclear chromosome segregation
I634_09475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I634_09495	COG1132	(ABC) transporter
I634_09500	COG1663	tetraacyldisaccharide 4'-kinase activity
I634_09535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I634_09540	COG0435	Glutathione S-transferase
I634_09545	COG1741	Belongs to the pirin family
I634_09550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I634_09560	COG0372	Belongs to the citrate synthase family
I634_09565	COG2009	succinate dehydrogenase
I634_09570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I634_09575	COG1053	succinate dehydrogenase
I634_09580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I634_09585	COG0567	Dehydrogenase, E1 component
I634_09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_09630	COG4667	esterase of the alpha-beta hydrolase superfamily
I634_09650	COG0366	Alpha amylase catalytic
I634_09675	COG1028	Short-chain dehydrogenase reductase Sdr
I634_09680	COG2267	carboxylic ester hydrolase activity
I634_09690	COG0616	signal peptide processing
I634_09710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_09715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I634_09720	COG0386	Belongs to the glutathione peroxidase family
I634_09725	COG2084	Dehydrogenase
I634_09735	COG1960	acyl-CoA dehydrogenase activity
I634_09740	COG1024	Enoyl-CoA hydratase
I634_09750	COG2226	methyltransferase
I634_09755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I634_09760	COG3083	sulfuric ester hydrolase activity
I634_09765	COG3082	Protein of unknown function (DUF1414)
I634_09770	COG3081	Nucleoid-associated protein
I634_09800	COG3275	phosphorelay sensor kinase activity
I634_09805	COG3279	Response regulator of the LytR AlgR family
I634_09810	COG0205	6-phosphofructokinase activity
I634_09860	COG2201	protein-glutamate methylesterase activity
I634_09885	COG0675	Transposase, IS605 OrfB family
I634_09930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_09945	COG2205	protein histidine kinase activity
I634_09945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_09965	COG0513	Belongs to the DEAD box helicase family
I634_09975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I634_09980	COG0583	DNA-binding transcription factor activity
I634_10000	COG5001	Diguanylate cyclase
I634_10000	COG2203	Gaf domain
I634_10000	COG3706	GGDEF domain
I634_10000	COG4251	negative regulation of phosphorylation
I634_10005	COG1760	l-serine dehydratase
I634_10030	COG1322	Protein conserved in bacteria
I634_10035	COG1404	Belongs to the peptidase S8 family
I634_10040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I634_10045	COG0022	dehydrogenase e1 component
I634_10055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I634_10060	COG0515	serine threonine protein kinase
I634_10065	COG1946	Acyl-CoA thioesterase
I634_10075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I634_10085	COG1956	GAF domain-containing protein
I634_10100	COG0793	Belongs to the peptidase S41A family
I634_10105	COG0733	neurotransmitter:sodium symporter activity
I634_10115	COG0308	aminopeptidase N
I634_10150	COG2902	Dehydrogenase
I634_10155	COG0167	dihydroorotate dehydrogenase activity
I634_10180	COG3130	regulation of translation
I634_10185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I634_10195	COG0415	Belongs to the DNA photolyase family
I634_10215	COG2059	Chromate
I634_10230	COG0415	Belongs to the DNA photolyase family
I634_10235	COG0415	Belongs to the DNA photolyase family
I634_10240	COG0415	Belongs to the DNA photolyase family
I634_10245	COG0415	Belongs to the DNA photolyase family
I634_10250	COG3046	protein related to deoxyribodipyrimidine photolyase
I634_10270	COG4974	Belongs to the 'phage' integrase family
I634_10280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I634_10285	COG0589	response to stress
I634_10295	COG0069	glutamate synthase activity
I634_10310	COG2193	ferroxidase activity
I634_10320	COG3278	Belongs to the heme-copper respiratory oxidase family
I634_10335	COG2010	Cytochrome c
I634_10360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I634_10365	COG0589	response to stress
I634_10370	COG0037	tRNA processing
I634_10375	COG1752	Esterase of the alpha-beta hydrolase superfamily
I634_10395	COG1280	lysine exporter protein (LysE YggA)
I634_10400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I634_10405	COG2897	thiosulfate sulfurtransferase activity
I634_10410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I634_10495	COG0582	viral genome integration into host DNA
I634_10505	COG0322	excinuclease ABC activity
I634_10510	COG2197	response regulator
I634_10515	COG0436	Aminotransferase
I634_10535	COG2259	Doxx family
I634_10540	COG0583	DNA-binding transcription factor activity
I634_10555	COG0670	Belongs to the BI1 family
I634_10560	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I634_10575	COG2920	part of a sulfur-relay system
I634_10615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I634_10625	COG0531	amino acid
I634_10625	COG1674	ftsk spoiiie
I634_10635	COG0686	Belongs to the AlaDH PNT family
I634_10640	COG0284	orotidine-5'-phosphate decarboxylase activity
I634_10645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I634_10660	COG0776	regulation of translation
I634_10665	COG0539	negative regulation of cytoplasmic translation
I634_10670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I634_10675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I634_10680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I634_10690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I634_10695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I634_10700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I634_10705	COG0633	Ferredoxin
I634_10740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I634_10745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I634_10755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I634_10765	COG4783	chaperone-mediated protein folding
I634_10775	COG1393	Belongs to the ArsC family
I634_10790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I634_10805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I634_10815	COG1960	acyl-CoA dehydrogenase activity
I634_10840	COG0572	uridine kinase
I634_10845	COG3769	mannosylglycerate metabolic process
I634_10850	COG1215	transferase activity, transferring glycosyl groups
I634_10855	COG0366	Alpha amylase catalytic
I634_10865	COG0303	'Molybdopterin
I634_10870	COG0534	Mate efflux family protein
I634_10885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I634_10890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I634_10940	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I634_10970	COG0405	Gamma-glutamyltransferase
I634_10975	COG1024	Enoyl-CoA hydratase
I634_11020	COG1448	Aminotransferase
I634_11040	COG1671	Belongs to the UPF0178 family
I634_11045	COG1028	Short-chain dehydrogenase reductase Sdr
I634_11050	COG1028	Short-chain dehydrogenase reductase Sdr
I634_11055	COG1960	acyl-CoA dehydrogenase activity
I634_11060	COG0662	Cupin 2, conserved barrel domain protein
I634_11060	COG2207	Transcriptional regulator
I634_11065	COG4771	TonB-dependent receptor
I634_11075	COG1505	serine-type exopeptidase activity
I634_11085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_11115	COG0596	Alpha beta hydrolase
I634_11125	COG0716	FMN binding
I634_11135	COG0735	belongs to the Fur family
I634_11145	COG1984	allophanate hydrolase subunit 2
I634_11150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I634_11155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I634_11160	COG2996	Protein conserved in bacteria
I634_11165	COG1765	OsmC-like protein
I634_11170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_11180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_11195	COG0436	Aminotransferase
I634_11200	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_11205	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_11215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_11215	COG2010	Cytochrome c
I634_11220	COG2080	2 iron, 2 sulfur cluster binding
I634_11245	COG1073	alpha beta
I634_11250	COG2207	Transcriptional regulator
I634_11260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_11265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I634_11290	COG3012	SEC-C Motif Domain Protein
I634_11300	COG0604	alcohol dehydrogenase
I634_11310	COG1960	acyl-CoA dehydrogenase activity
I634_11320	COG4771	TonB-dependent receptor
I634_11345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I634_11350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I634_11370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I634_11380	COG0521	Mo-molybdopterin cofactor biosynthetic process
I634_11395	COG2161	toxin-antitoxin pair type II binding
I634_11400	COG4115	mRNA cleavage
I634_11415	COG0436	Aminotransferase
I634_11420	COG3268	Saccharopine dehydrogenase
I634_11425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I634_11440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I634_11445	COG4206	TonB-dependent receptor
I634_11455	COG5006	permease, DMT superfamily
I634_11470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I634_11475	COG1074	ATP-dependent DNA helicase activity
I634_11480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I634_11495	COG1022	Amp-dependent synthetase and ligase
I634_11500	COG2203	Gaf domain
I634_11500	COG4251	negative regulation of phosphorylation
I634_11500	COG3706	GGDEF domain
I634_11500	COG5001	Diguanylate cyclase
I634_11520	COG0583	DNA-binding transcription factor activity
I634_11540	COG0640	Transcriptional regulator
I634_11560	COG2204	response regulator
I634_11570	COG4251	negative regulation of phosphorylation
I634_11575	COG0784	Response regulator, receiver
I634_11580	COG0784	Response regulator, receiver
I634_11580	COG2205	protein histidine kinase activity
I634_11605	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I634_11630	COG3139	Protein of unknown function (DUF1315)
I634_11645	COG1115	amino acid carrier protein
I634_11650	COG2866	Carboxypeptidase
I634_11670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I634_11680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I634_11685	COG1640	4-alpha-glucanotransferase
I634_11690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I634_11695	COG0676	glucose-6-phosphate 1-epimerase activity
I634_11700	COG0800	Aldolase
I634_11710	COG0129	dihydroxy-acid dehydratase activity
I634_11720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I634_11725	COG1737	Transcriptional regulator
I634_11730	COG0469	pyruvate kinase activity
I634_11735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_11755	COG2823	Periplasmic or secreted lipoprotein
I634_11785	COG3665	Urea carboxylase-associated protein
I634_11810	COG1028	Short-chain dehydrogenase reductase Sdr
I634_11825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I634_11840	COG2721	sulfolactate sulfo-lyase activity
I634_11845	COG1904	glucuronate isomerase
I634_11850	COG0246	Mannitol dehydrogenase
I634_11855	COG0800	Aldolase
I634_11860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_11865	COG2755	lipolytic protein G-D-S-L family
I634_11875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I634_11885	COG4677	pectinesterase activity
I634_11905	COG2356	endonuclease I
I634_11910	COG0840	transmembrane signaling receptor activity
I634_11925	COG0583	DNA-binding transcription factor activity
I634_11930	COG1979	alcohol dehydrogenase
I634_11935	COG5001	Diguanylate cyclase
I634_11945	COG0784	Response regulator, receiver
I634_11945	COG3437	response regulator, receiver
I634_11950	COG4191	Histidine kinase
I634_11950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I634_11960	COG0471	metal ion transport
I634_11970	COG0489	protein tyrosine kinase activity
I634_11975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_11975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I634_11980	COG0668	transmembrane transport
I634_11985	COG2226	methyltransferase
I634_11990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_11995	COG1388	LysM domain
I634_11995	COG0741	lytic transglycosylase activity
I634_12020	COG0215	cysteine-tRNA ligase activity
I634_12025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I634_12035	COG1785	Belongs to the alkaline phosphatase family
I634_12040	COG1785	Belongs to the alkaline phosphatase family
I634_12055	COG2268	Band 7 protein
I634_12060	COG0583	DNA-binding transcription factor activity
I634_12065	COG1028	Short-chain dehydrogenase reductase Sdr
I634_12080	COG1733	regulation of RNA biosynthetic process
I634_12085	COG0604	alcohol dehydrogenase
I634_12090	COG0753	catalase activity
I634_12095	COG0604	alcohol dehydrogenase
I634_12100	COG0583	DNA-binding transcription factor activity
I634_12125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I634_12130	COG1286	toxin biosynthetic process
I634_12135	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I634_12140	COG0285	dihydrofolate synthase activity
I634_12170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I634_12175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I634_12195	COG3609	addiction module antidote protein, CC2985 family
I634_12200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I634_12205	COG0318	PFAM AMP-dependent synthetase and ligase
I634_12215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I634_12215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I634_12250	COG0789	Transcriptional regulator
I634_12255	COG0604	alcohol dehydrogenase
I634_12270	COG1119	ATPase activity
I634_12275	COG2031	fatty acid transporter
I634_12280	COG0784	Response regulator, receiver
I634_12280	COG5002	protein histidine kinase activity
I634_12280	COG2205	protein histidine kinase activity
I634_12290	COG0612	Peptidase, M16
I634_12305	COG3101	peptidyl-lysine hydroxylation
I634_12330	COG1902	pentaerythritol trinitrate reductase activity
I634_12330	COG0446	pyridine nucleotide-disulphide oxidoreductase
I634_12365	COG4399	Belongs to the UPF0754 family
I634_12390	COG1770	oligopeptidase
I634_12395	COG2186	Transcriptional regulator
I634_12405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I634_12410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I634_12420	COG2983	Belongs to the UPF0260 family
I634_12425	COG0179	Fumarylacetoacetate (FAA) hydrolase
I634_12440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I634_12445	COG0318	PFAM AMP-dependent synthetase and ligase
I634_12450	COG2267	carboxylic ester hydrolase activity
I634_12465	COG1214	PFAM Peptidase M22, glycoprotease
I634_12470	COG1199	ATP-dependent helicase activity
I634_12520	COG4771	TonB-dependent receptor
I634_12530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I634_12535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I634_12540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I634_12545	COG0131	Imidazoleglycerol-phosphate dehydratase
I634_12545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I634_12550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I634_12565	COG0140	phosphoribosyl-ATP diphosphatase activity
I634_12565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I634_12580	COG2116	formate transmembrane transporter activity
I634_12585	COG0612	Peptidase, M16
I634_12610	COG0326	Molecular chaperone. Has ATPase activity
I634_12615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I634_12645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I634_12655	COG3220	belongs to the UPF0276 family
I634_12665	COG1136	(ABC) transporter
I634_12665	COG0577	efflux transmembrane transporter activity
I634_12675	COG2203	Gaf domain
I634_12675	COG3706	GGDEF domain
I634_12675	COG5001	Diguanylate cyclase
I634_12675	COG4251	negative regulation of phosphorylation
I634_12680	COG1183	phosphatidylcholine synthase activity
I634_12695	COG0457	Tetratricopeptide repeat
I634_12700	COG0277	FAD linked oxidase domain protein
I634_12705	COG0542	response to heat
I634_12715	COG0564	pseudouridine synthase activity
I634_12730	COG1595	DNA-templated transcription, initiation
I634_12745	COG4221	oxidoreductase activity
I634_12760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I634_12770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I634_12780	COG0142	geranyltranstransferase activity
I634_12790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I634_12795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I634_12805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I634_12820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I634_12820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I634_12840	COG0488	(ABC) transporter
I634_12850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I634_12860	COG0560	Phosphoserine phosphatase
I634_12870	COG0084	hydrolase, TatD family'
I634_12885	COG0571	ribonuclease III activity
I634_12890	COG0681	Belongs to the peptidase S26 family
I634_12915	COG1595	DNA-templated transcription, initiation
I634_12925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I634_12940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I634_13020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I634_13025	COG1047	Peptidyl-prolyl cis-trans
I634_13035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I634_13040	COG0196	riboflavin kinase activity
I634_13045	COG0728	peptidoglycan biosynthetic process
I634_13050	COG0268	Binds directly to 16S ribosomal RNA
I634_13070	COG0385	Bile acid
I634_13100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_13105	COG0776	regulation of translation
I634_13110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I634_13115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I634_13120	COG0740	serine-type endopeptidase activity
I634_13125	COG0544	peptidyl-prolyl cis-trans isomerase activity
I634_13140	COG1720	tRNA m6t6A37 methyltransferase activity
I634_13150	COG1234	tRNA 3'-trailer cleavage
I634_13160	COG0123	including yeast histone deacetylase and acetoin utilization protein
I634_13185	COG0516	GMP reductase activity
I634_13185	COG0517	IMP dehydrogenase activity
I634_13190	COG1570	exodeoxyribonuclease VII activity
I634_13210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I634_13215	COG2976	Protein conserved in bacteria
I634_13240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I634_13250	COG2166	iron-sulfur cluster assembly
I634_13265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I634_13270	COG0719	Fe-S assembly protein
I634_13275	COG0396	ATPase activity
I634_13280	COG0719	Fe-S assembly protein
I634_13285	COG1104	cysteine desulfurase activity
I634_13290	COG1959	2 iron, 2 sulfur cluster binding
I634_13295	COG2072	flavoprotein involved in K transport
I634_13300	COG1045	serine acetyltransferase
I634_13305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I634_13310	COG0483	inositol monophosphate 1-phosphatase activity
I634_13325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I634_13330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I634_13335	COG1862	Preprotein translocase
I634_13340	COG0343	queuine tRNA-ribosyltransferase activity
I634_13360	COG1842	Phage shock protein A
I634_13365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I634_13385	COG0754	glutathionylspermidine amidase activity
I634_13415	COG2066	Belongs to the glutaminase family
I634_13420	COG1785	Belongs to the alkaline phosphatase family
I634_13485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I634_13515	COG0438	transferase activity, transferring glycosyl groups
I634_13530	COG0367	asparagine synthase
I634_13535	COG0438	transferase activity, transferring glycosyl groups
I634_13555	COG0110	maltose O-acetyltransferase activity
I634_13560	COG2244	polysaccharide biosynthetic process
I634_13585	COG2327	Polysaccharide pyruvyl transferase
I634_13625	COG0489	protein tyrosine kinase activity
I634_13635	COG3267	Type II secretory pathway component ExeA
I634_13635	COG3409	Peptidoglycan-binding domain 1 protein
I634_13640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I634_13640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I634_13670	COG1560	Kdo2-lipid A biosynthetic process
I634_13685	COG1960	acyl-CoA dehydrogenase activity
I634_13700	COG5001	Diguanylate cyclase
I634_13700	COG3300	MHYT domain
I634_13705	COG1435	thymidine kinase activity
I634_13715	COG1609	Transcriptional regulator
I634_13720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I634_13760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I634_13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I634_13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
I634_13770	COG1024	Enoyl-CoA hydratase
I634_13785	COG1012	belongs to the aldehyde dehydrogenase family
I634_13805	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I634_13810	COG0789	Transcriptional regulator
I634_13840	COG1960	acyl-CoA dehydrogenase activity
I634_13870	COG0745	RESPONSE REGULATOR receiver
I634_13875	COG2205	protein histidine kinase activity
I634_13915	COG2080	2 iron, 2 sulfur cluster binding
I634_13920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I634_13925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I634_13945	COG1028	Short-chain dehydrogenase reductase Sdr
I634_13950	COG4221	oxidoreductase activity
I634_13955	COG0693	protein deglycase activity
I634_13960	COG1295	ribonuclease BN
I634_13970	COG4681	YaeQ
I634_14000	COG2814	Major facilitator Superfamily
I634_14015	COG0514	ATP-dependent DNA helicase (RecQ)
I634_14045	COG4251	negative regulation of phosphorylation
I634_14060	COG2133	pyrroloquinoline quinone binding
I634_14075	COG0830	nickel cation binding
I634_14100	COG0829	nickel cation binding
I634_14105	COG0410	ABC transporter
I634_14140	COG0745	RESPONSE REGULATOR receiver
I634_14150	COG1484	DNA-dependent DNA replication
I634_14165	COG1192	Involved in chromosome partitioning
I634_14205	COG5002	protein histidine kinase activity
I634_14205	COG5001	Diguanylate cyclase
I634_14205	COG3447	MASE1 domain protein
I634_14215	COG0840	transmembrane signaling receptor activity
I634_14220	COG5001	Diguanylate cyclase
I634_14220	COG3300	MHYT domain
I634_14225	COG3177	Filamentation induced by cAMP protein fic
I634_14260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I634_14385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I634_14390	COG2971	BadF BadG BcrA BcrD
I634_14395	COG0583	DNA-binding transcription factor activity
I634_14400	COG1620	l-lactate permease
I634_14425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_14430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I634_14435	COG0006	proline dipeptidase activity
I634_14445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_14460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I634_14465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I634_14470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I634_14490	COG3313	Fe-S protein
I634_14520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_14525	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_14530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I634_14535	COG2186	Transcriptional regulator
I634_14545	COG3023	N-Acetylmuramoyl-L-alanine amidase
I634_14550	COG3577	Aspartyl protease
I634_14555	COG0157	Belongs to the NadC ModD family
I634_14560	COG4969	Belongs to the N-Me-Phe pilin family
I634_14565	COG1459	type II secretion system
I634_14575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I634_14575	COG0237	dephospho-CoA kinase activity
I634_14580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I634_14590	COG3608	succinylglutamate desuccinylase aspartoacylase
I634_14595	COG0494	nUDIX hydrolase
I634_14605	COG0739	heme binding
I634_14610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I634_14615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I634_14620	COG0849	cell division
I634_14625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I634_14630	COG1181	Belongs to the D-alanine--D-alanine ligase family
I634_14635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I634_14645	COG0772	Belongs to the SEDS family
I634_14650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I634_14660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I634_14665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I634_14670	COG0768	penicillin binding
I634_14675	COG3116	cell division
I634_14685	COG2001	Belongs to the MraZ family
I634_14710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I634_14735	COG0678	peroxiredoxin activity
I634_14735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I634_14750	COG3706	GGDEF domain
I634_14760	COG2204	response regulator
I634_14765	COG0784	Response regulator, receiver
I634_14765	COG2205	protein histidine kinase activity
I634_14795	COG0668	transmembrane transport
I634_14800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I634_14805	COG0189	ligase activity
I634_14810	COG1678	Uncharacterized ACR, COG1678
I634_14815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I634_14840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I634_14845	COG0762	integral membrane protein
I634_14855	COG1902	pentaerythritol trinitrate reductase activity
I634_14855	COG0446	pyridine nucleotide-disulphide oxidoreductase
I634_14870	COG0625	glutathione transferase activity
I634_14880	COG1764	response to oxidative stress
I634_14885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I634_14900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I634_14910	COG2814	Major facilitator Superfamily
I634_14915	COG0724	RNA recognition motif
I634_14945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I634_14950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I634_14955	COG0083	homoserine kinase activity
I634_14970	COG0583	DNA-binding transcription factor activity
I634_14985	COG0640	Transcriptional regulator
I634_14995	COG0431	NADPH-dependent FMN reductase
I634_15000	COG0798	PFAM Bile acid sodium symporter
I634_15005	COG2201	protein-glutamate methylesterase activity
I634_15010	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I634_15020	COG0642	Histidine kinase
I634_15040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I634_15070	COG1748	Saccharopine dehydrogenase
I634_15085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I634_15090	COG3107	peptidoglycan biosynthetic process
I634_15105	COG0438	transferase activity, transferring glycosyl groups
I634_15115	COG2823	Periplasmic or secreted lipoprotein
I634_15135	COG4585	Histidine kinase
I634_15140	COG2197	response regulator
I634_15155	COG4771	TonB-dependent receptor
I634_15165	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I634_15170	COG0372	Belongs to the citrate synthase family
I634_15175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I634_15180	COG2828	Protein conserved in bacteria
I634_15185	COG2199	diguanylate cyclase activity
I634_15185	COG2203	Gaf domain
I634_15190	COG1940	carbohydrate kinase activity
I634_15230	COG0784	Response regulator, receiver
I634_15230	COG2198	Histidine kinase
I634_15230	COG5002	protein histidine kinase activity
I634_15235	COG3023	N-Acetylmuramoyl-L-alanine amidase
I634_15240	COG0070	glutamate synthase
I634_15240	COG0069	glutamate synthase activity
I634_15240	COG0067	glutamate synthase
I634_15245	COG0493	'glutamate synthase
I634_15260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I634_15265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I634_15270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I634_15275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I634_15290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I634_15295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I634_15305	COG4942	peptidase
I634_15310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I634_15315	COG0738	Major facilitator superfamily
I634_15325	COG1902	pentaerythritol trinitrate reductase activity
I634_15345	COG0625	glutathione transferase activity
I634_15370	COG2894	cell division
I634_15375	COG0850	regulation of cytokinetic process
I634_15385	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I634_15415	COG1914	H( )-stimulated, divalent metal cation uptake system
I634_15420	COG0436	Aminotransferase
I634_15440	COG0174	glutamine synthetase
I634_15450	COG3852	Histidine kinase
I634_15455	COG2204	response regulator
I634_15460	COG3437	response regulator, receiver
I634_15465	COG0204	Acyl-transferase
I634_15480	COG3706	GGDEF domain
I634_15500	COG2205	protein histidine kinase activity
I634_15500	COG3437	response regulator, receiver
I634_15500	COG3850	Histidine kinase
I634_15500	COG4999	Histidine kinase
I634_15505	COG0525	valine-tRNA ligase activity
I634_15510	COG2927	DNA polymerase III (CHI subunit)
I634_15515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I634_15520	COG0795	lipopolysaccharide-transporting ATPase activity
I634_15525	COG0795	lipopolysaccharide-transporting ATPase activity
I634_15615	COG3250	beta-galactosidase activity
I634_15625	COG4948	Mandelate Racemase Muconate Lactonizing
I634_15630	COG3661	Belongs to the glycosyl hydrolase 67 family
I634_15645	COG2199	diguanylate cyclase activity
I634_15645	COG2203	Gaf domain
I634_15670	COG0673	inositol 2-dehydrogenase activity
I634_15675	COG5002	protein histidine kinase activity
I634_15680	COG0628	permease
I634_15695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I634_15700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I634_15705	COG4558	Periplasmic binding protein
I634_15715	COG4206	TonB-dependent receptor
I634_15725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I634_15730	COG0697	spore germination
I634_15760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I634_15780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I634_15835	COG1131	(ABC) transporter
I634_15845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I634_15855	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I634_15895	COG2205	protein histidine kinase activity
I634_15905	COG3901	Regulator of nitric oxide reductase transcription
I634_15905	COG0348	domain, Protein
I634_15915	COG2197	response regulator
I634_15945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I634_15960	COG4771	TonB-dependent receptor
I634_15970	COG0583	DNA-binding transcription factor activity
I634_15975	COG1304	FMN binding
I634_15980	COG0277	FAD linked oxidase domain protein
I634_15990	COG1462	curli production assembly transport component CsgG
I634_16020	COG2197	response regulator
I634_16030	COG1028	Short-chain dehydrogenase reductase Sdr
I634_16045	COG0513	Belongs to the DEAD box helicase family
I634_16070	COG0800	Aldolase
I634_16075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_16080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_16095	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I634_16095	COG3264	Mechanosensitive ion channel
I634_16115	COG0840	transmembrane signaling receptor activity
I634_16140	COG0730	response to heat
I634_16160	COG4191	Histidine kinase
I634_16170	COG0417	DNA replication proofreading
I634_16180	COG0318	PFAM AMP-dependent synthetase and ligase
I634_16200	COG1309	transcriptional regulator
I634_16210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_16220	COG1573	uracil-dna glycosylase
I634_16225	COG0784	Response regulator, receiver
I634_16225	COG3437	response regulator, receiver
I634_16245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I634_16270	COG1983	PspC domain protein
I634_16275	COG1842	Phage shock protein A
I634_16285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_16315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I634_16315	COG2885	chlorophyll binding
I634_16320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I634_16330	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I634_16345	COG0204	Acyl-transferase
I634_16350	COG0668	transmembrane transport
I634_16365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I634_16370	COG0733	neurotransmitter:sodium symporter activity
I634_16385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I634_16400	COG0716	FMN binding
I634_16410	COG0848	biopolymer transport protein
I634_16430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I634_16445	COG1215	transferase activity, transferring glycosyl groups
I634_16455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I634_16460	COG0702	epimerase
I634_16475	COG5001	Diguanylate cyclase
I634_16475	COG5002	protein histidine kinase activity
I634_16485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I634_16495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_16505	COG0583	DNA-binding transcription factor activity
I634_16510	COG0121	glutamine amidotransferase
I634_16520	COG4682	membrane
I634_16540	COG1953	Uracil, thiamine, allantoin
I634_16545	COG4771	TonB-dependent receptor
I634_16555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I634_16560	COG0778	Nitroreductase
I634_16565	COG0596	Alpha beta hydrolase
I634_16570	COG0251	oxidation-reduction process
I634_16575	COG1335	isochorismatase
I634_16580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I634_16585	COG1309	transcriptional regulator
I634_16600	COG4628	conserved protein (DUF2132)
I634_16605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I634_16615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I634_16635	COG1477	protein flavinylation
I634_16640	COG2871	sodium ion transport
I634_16645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_16650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_16655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_16660	COG1805	sodium ion transport
I634_16665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I634_16670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I634_16675	COG0545	Peptidyl-prolyl cis-trans isomerase
I634_16680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I634_16695	COG0039	L-malate dehydrogenase activity
I634_16700	COG1438	arginine binding
I634_16725	COG0572	uridine kinase
I634_16730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I634_16750	COG0745	RESPONSE REGULATOR receiver
I634_16750	COG3706	GGDEF domain
I634_16755	COG2176	DNA-directed DNA polymerase activity
I634_16765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I634_16785	COG0189	ligase activity
I634_16795	COG0189	ligase activity
I634_16795	COG4067	protein conserved in archaea
I634_16820	COG1283	sodium-dependent phosphate transmembrane transporter activity
I634_16825	COG0667	Aldo Keto reductase
I634_16835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I634_16845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I634_16875	COG2274	protein secretion by the type I secretion system
I634_16880	COG0583	DNA-binding transcription factor activity
I634_16905	COG0438	transferase activity, transferring glycosyl groups
I634_16905	COG1216	Glycosyl transferase, family 2
I634_16915	COG1091	dTDP-4-dehydrorhamnose reductase activity
I634_16925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I634_16930	COG0457	Tetratricopeptide repeat
I634_16995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I634_17005	COG2161	toxin-antitoxin pair type II binding
I634_17015	COG0202	RNA polymerase activity
I634_17040	COG0201	protein transport
I634_17060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I634_17095	COG5002	protein histidine kinase activity
I634_17095	COG0784	Response regulator, receiver
I634_17125	COG0557	exoribonuclease II activity
I634_17170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I634_17185	COG0543	2 iron, 2 sulfur cluster binding
I634_17200	COG2234	aminopeptidase activity
I634_17210	COG4251	negative regulation of phosphorylation
I634_17220	COG1271	oxidase subunit
I634_17225	COG1294	oxidase, subunit
I634_17235	COG1522	sequence-specific DNA binding
I634_17245	COG1278	Cold shock
I634_17250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I634_17270	COG0339	signal peptide processing
I634_17275	COG2201	protein-glutamate methylesterase activity
I634_17285	COG3852	Histidine kinase
I634_17295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I634_17300	COG0243	molybdopterin cofactor binding
I634_17305	COG0823	Involved in the tonB-independent uptake of proteins
I634_17305	COG1506	peptidase
I634_17305	COG4946	Tricorn protease homolog
I634_17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I634_17365	COG2197	response regulator
I634_17375	COG0189	ligase activity
I634_17395	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I634_17400	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I634_17405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I634_17420	COG0281	malic enzyme
I634_17430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I634_17460	COG0456	acetyltransferase
I634_17470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I634_17475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I634_17480	COG2177	Part of the ABC transporter FtsEX involved in
I634_17485	COG2884	Cell division ATP-binding protein ftsE
I634_17500	COG0742	ribosomal rna small subunit methyltransferase
I634_17510	COG2095	MarC family integral membrane protein
I634_17530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I634_17535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I634_17540	COG0617	tRNA 3'-terminal CCA addition
I634_17545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I634_17560	COG0076	glutamate decarboxylase activity
I634_17575	COG0842	Transport permease protein
I634_17580	COG1131	(ABC) transporter
I634_17585	COG0745	RESPONSE REGULATOR receiver
I634_17590	COG2205	protein histidine kinase activity
I634_17595	COG4774	siderophore transport
I634_17610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I634_17615	COG0049	tRNA binding
I634_17620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I634_17625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I634_17630	COG0085	RNA polymerase activity
I634_17640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I634_17645	COG0081	regulation of translation
I634_17650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I634_17670	COG1132	(ABC) transporter
I634_17675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I634_17680	COG3590	peptidase
I634_17690	COG0513	Belongs to the DEAD box helicase family
I634_17695	COG0418	dihydroorotase activity
I634_17700	COG3040	lipid binding
I634_17705	COG4989	oxidoreductase activity
I634_17710	COG0346	lactoylglutathione lyase activity
I634_17715	COG0668	transmembrane transport
I634_17735	COG0302	gtp cyclohydrolase
I634_17745	COG2957	Belongs to the agmatine deiminase family
I634_17750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I634_17760	COG1201	RNA secondary structure unwinding
I634_17770	COG1793	dna ligase
I634_17775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I634_17780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I634_17795	COG0625	glutathione transferase activity
I634_17800	COG0625	glutathione transferase activity
I634_17810	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I634_17825	COG1012	belongs to the aldehyde dehydrogenase family
I634_17830	COG0028	Belongs to the TPP enzyme family
I634_17840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I634_17845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I634_17850	COG0330	HflC and HflK could
I634_17855	COG0330	HflC and HflK could
I634_17860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I634_17865	COG1923	regulation of RNA biosynthetic process
I634_17870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I634_17885	COG0802	atpase or kinase
I634_17890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I634_17890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I634_17895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I634_17905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I634_17915	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I634_17920	COG0735	belongs to the Fur family
I634_17930	COG0432	Pfam Uncharacterised protein family UPF0047
I634_17940	COG0305	Participates in initiation and elongation during chromosome replication
I634_17965	COG2258	MOSC domain
I634_17995	COG0784	Response regulator, receiver
I634_17995	COG2205	protein histidine kinase activity
I634_17995	COG2198	Histidine kinase
I634_18005	COG0577	efflux transmembrane transporter activity
I634_18005	COG1136	(ABC) transporter
I634_18015	COG0840	transmembrane signaling receptor activity
I634_18020	COG5002	protein histidine kinase activity
I634_18025	COG0840	transmembrane signaling receptor activity
I634_18055	COG1472	Belongs to the glycosyl hydrolase 3 family
I634_18065	COG2723	6-phospho-beta-galactosidase activity
I634_18070	COG1609	Transcriptional regulator
I634_18075	COG2814	Major facilitator Superfamily
I634_18075	COG0477	Major facilitator Superfamily
I634_18080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I634_18085	COG4988	ABC transporter
I634_18090	COG4890	Cyd operon protein YbgT
I634_18095	COG1294	oxidase, subunit
I634_18110	COG2204	response regulator
I634_18135	COG4319	ketosteroid isomerase
I634_18145	COG3706	GGDEF domain
I634_18155	COG2375	cellular response to nickel ion
I634_18160	COG3237	CsbD-like
I634_18185	COG0508	dehydrogenase complex catalyzes the overall conversion of
I634_18185	COG0596	Alpha beta hydrolase
I634_18205	COG3038	cytochrome b561
I634_18215	COG1252	NADH dehydrogenase
I634_18230	COG0583	DNA-binding transcription factor activity
I634_18235	COG2067	long-chain fatty acid transport protein
I634_18240	COG2130	NADP-dependent
I634_18245	COG5001	Diguanylate cyclase
I634_18245	COG3706	GGDEF domain
I634_18245	COG2203	Gaf domain
I634_18245	COG4251	negative regulation of phosphorylation
I634_18250	COG0784	Response regulator, receiver
I634_18250	COG2205	protein histidine kinase activity
I634_18265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I634_18270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I634_18275	COG1349	DNA-binding transcription factor activity
I634_18280	COG0673	inositol 2-dehydrogenase activity
I634_18295	COG0697	spore germination
I634_18300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I634_18305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I634_18310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I634_18315	COG1166	arginine decarboxylase activity
I634_18325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I634_18330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I634_18335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I634_18380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I634_18385	COG0109	protoheme IX farnesyltransferase activity
I634_18405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I634_18455	COG1324	tolerance protein
I634_18460	COG4232	protein-disulfide reductase activity
I634_18465	COG0739	heme binding
I634_18470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I634_18475	COG0511	ligase activity, forming carbon-carbon bonds
I634_18480	COG0439	Biotin carboxylase
I634_18525	COG0154	amidase activity
I634_18540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I634_18545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I634_18560	COG0151	Belongs to the GarS family
I634_18575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I634_18580	COG3954	Phosphoribulokinase
I634_18590	COG0745	RESPONSE REGULATOR receiver
I634_18610	COG1501	Belongs to the glycosyl hydrolase 31 family
I634_18620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I634_18630	COG3031	protein transport across the cell outer membrane
I634_18640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I634_18645	COG1459	type II secretion system
I634_18650	COG2165	general secretion pathway protein
I634_18655	COG2165	general secretion pathway protein
I634_18660	COG2165	general secretion pathway protein
I634_18665	COG4795	General secretion pathway protein
I634_18680	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I634_18695	COG1012	belongs to the aldehyde dehydrogenase family
I634_18705	COG1011	Hydrolase
I634_18710	COG0494	nUDIX hydrolase
I634_18715	COG1218	3'(2'),5'-bisphosphate nucleotidase
I634_18730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I634_18740	COG3089	Belongs to the UPF0270 family
I634_18745	COG0429	hydrolase of the alpha beta-hydrolase fold
I634_18755	COG0488	(ABC) transporter
I634_18775	COG2900	Belongs to the SlyX family
I634_18785	COG0545	Peptidyl-prolyl cis-trans isomerase
I634_18795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I634_18800	COG2183	response to ionizing radiation
I634_18820	COG0596	Alpha beta hydrolase
I634_18825	COG1040	competence protein
I634_18845	COG1794	racemase activity, acting on amino acids and derivatives
I634_18855	COG0534	Mate efflux family protein
I634_18870	COG1999	signal sequence binding
I634_18875	COG0109	protoheme IX farnesyltransferase activity
I634_18880	COG1612	heme a metabolic process
I634_18900	COG1845	cytochrome c oxidase, subunit III
I634_18905	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I634_18910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I634_18915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I634_18930	COG3706	GGDEF domain
I634_18945	COG0129	dihydroxy-acid dehydratase activity
I634_18955	COG0606	chelatase, subunit chli
I634_18960	COG0583	DNA-binding transcription factor activity
I634_18970	COG2814	Major facilitator Superfamily
I634_18980	COG0729	surface antigen
I634_18985	COG2911	Protein conserved in bacteria
I634_19010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I634_19020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I634_19040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I634_19060	COG1228	amidohydrolase
I634_19085	COG0425	Belongs to the sulfur carrier protein TusA family
I634_19105	COG1561	YicC-like family, N-terminal region
I634_19200	COG3177	Filamentation induced by cAMP protein fic
I634_19210	COG1609	Transcriptional regulator
I634_19225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I634_19225	COG2199	diguanylate cyclase activity
I634_19250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I634_19270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I634_19275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I634_19295	COG1475	DNA binding
I634_19300	COG1192	Involved in chromosome partitioning
I634_19325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I634_19340	COG0706	membrane insertase activity
I634_19345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I634_19350	COG0594	ribonuclease P activity
I634_19355	COG0230	Belongs to the bacterial ribosomal protein bL34 family