locus-tag	class	description
I636_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I636_00020	COG0187	DNA topoisomerase II activity
I636_00040	COG2818	Glycosylase
I636_00050	COG3078	GTPase activator activity
I636_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I636_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I636_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I636_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I636_00085	COG0569	domain protein
I636_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I636_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I636_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I636_00110	COG0758	DNA mediated transformation
I636_00125	COG0009	L-threonylcarbamoyladenylate synthase
I636_00130	COG0408	coproporphyrinogen oxidase activity
I636_00135	COG3047	cAMP biosynthetic process
I636_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I636_00210	COG2234	aminopeptidase activity
I636_00215	COG0463	Glycosyl transferase, family 2
I636_00225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I636_00250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_00280	COG3642	lipopolysaccharide core region biosynthetic process
I636_00285	COG0859	PFAM glycosyl transferase family 9
I636_00315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_00330	COG3161	chorismate lyase activity
I636_00335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I636_00355	COG0210	DNA helicase
I636_00400	COG1959	2 iron, 2 sulfur cluster binding
I636_00405	COG0730	response to heat
I636_00420	COG4771	TonB-dependent receptor
I636_00435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I636_00440	COG4988	ABC transporter
I636_00450	COG1271	oxidase subunit
I636_00460	COG0425	Belongs to the sulfur carrier protein TusA family
I636_00460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_00470	COG0450	alkyl hydroperoxide reductase
I636_00480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I636_00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_00555	COG0270	DNA (cytosine-5-)-methyltransferase activity
I636_00560	COG0556	nucleotide-excision repair
I636_00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_00575	COG1129	ABC transporter
I636_00575	COG0842	Transport permease protein
I636_00580	COG0842	Transport permease protein
I636_00595	COG1960	acyl-CoA dehydrogenase activity
I636_00600	COG0583	DNA-binding transcription factor activity
I636_00610	COG3106	COG3106 Predicted ATPase
I636_00630	COG2184	nucleotidyltransferase activity
I636_00635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I636_00650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I636_00655	COG0352	thiamine-phosphate diphosphorylase activity
I636_00665	COG3071	HemY protein
I636_00670	COG2959	enzyme of heme biosynthesis
I636_00680	COG0181	hydroxymethylbilane synthase activity
I636_00700	COG0194	GDP metabolic process
I636_00710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I636_00720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I636_00725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I636_00735	COG0678	peroxiredoxin activity
I636_00755	COG1178	ABC-type Fe3 transport system permease component
I636_00760	COG3842	ATPase activity
I636_00765	COG0668	transmembrane transport
I636_00770	COG2081	HI0933 family
I636_00790	COG4372	Transposase
I636_00805	COG2963	transposase activity
I636_00810	COG2801	Transposase and inactivated derivatives
I636_00825	COG2200	EAL domain
I636_00830	COG0583	DNA-binding transcription factor activity
I636_00840	COG2076	Multidrug Resistance protein
I636_00855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_00870	COG0427	acetyl-CoA hydrolase
I636_00875	COG0123	including yeast histone deacetylase and acetoin utilization protein
I636_00890	COG0840	transmembrane signaling receptor activity
I636_00900	COG3064	Membrane
I636_00910	COG5002	protein histidine kinase activity
I636_00910	COG5001	Diguanylate cyclase
I636_00925	COG0514	ATP-dependent DNA helicase (RecQ)
I636_00930	COG2239	Acts as a magnesium transporter
I636_00935	COG2962	Rard protein
I636_00940	COG0745	RESPONSE REGULATOR receiver
I636_00940	COG3706	GGDEF domain
I636_00945	COG0210	DNA helicase
I636_00955	COG1011	Hydrolase
I636_00970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I636_00975	COG0019	diaminopimelate decarboxylase activity
I636_01005	COG0163	prenyltransferase activity
I636_01010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I636_01020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I636_01040	COG1077	Cell shape determining protein MreB Mrl
I636_01050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I636_01055	COG2814	Major facilitator Superfamily
I636_01060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_01090	COG1085	galactose-1-phosphate uridylyltransferase
I636_01095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I636_01105	COG0629	single-stranded DNA binding
I636_01120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I636_01125	COG3250	beta-galactosidase activity
I636_01150	COG1349	DNA-binding transcription factor activity
I636_01195	COG3267	Type II secretory pathway component ExeA
I636_01195	COG3409	Peptidoglycan-binding domain 1 protein
I636_01210	COG1459	type II secretion system
I636_01255	COG1077	Cell shape determining protein MreB Mrl
I636_01260	COG1792	Involved in formation and maintenance of cell shape
I636_01265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I636_01275	COG1530	ribonuclease E activity
I636_01285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_01290	COG0312	modulator of DNA gyrase
I636_01295	COG3028	Belongs to the UPF0307 family
I636_01300	COG0312	modulator of DNA gyrase
I636_01310	COG0745	RESPONSE REGULATOR receiver
I636_01315	COG4191	Histidine kinase
I636_01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_01320	COG0297	glycogen (starch) synthase activity
I636_01330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I636_01335	COG0596	Alpha beta hydrolase
I636_01355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I636_01360	COG5002	protein histidine kinase activity
I636_01365	COG0745	RESPONSE REGULATOR receiver
I636_01390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_01490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I636_01520	COG0375	protein maturation
I636_01530	COG0409	Hydrogenase expression formation protein
I636_01540	COG0309	Hydrogenase expression formation protein (HypE)
I636_01545	COG0789	Transcriptional regulator
I636_01550	COG2217	Heavy metal translocating P-type atpase
I636_01640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I636_01650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I636_01660	COG0463	Glycosyl transferase, family 2
I636_01665	COG0745	RESPONSE REGULATOR receiver
I636_01670	COG5002	protein histidine kinase activity
I636_01695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I636_01700	COG0789	Transcriptional regulator
I636_01705	COG2217	Heavy metal translocating P-type atpase
I636_01745	COG0531	amino acid
I636_01755	COG2132	Multicopper oxidase
I636_01810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_01835	COG1185	polyribonucleotide nucleotidyltransferase activity
I636_01865	COG1819	glycosyl
I636_01925	COG0546	phosphoglycolate phosphatase activity
I636_01950	COG1609	Transcriptional regulator
I636_01955	COG0673	inositol 2-dehydrogenase activity
I636_01965	COG2211	Major facilitator Superfamily
I636_01990	COG1454	alcohol dehydrogenase
I636_02040	COG0089	rRNA binding
I636_02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I636_02060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I636_02075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I636_02080	COG0438	transferase activity, transferring glycosyl groups
I636_02090	COG1519	Transferase
I636_02125	COG0788	formyltetrahydrofolate deformylase activity
I636_02135	COG1643	Atp-dependent helicase
I636_02140	COG2951	lytic endotransglycosylase activity
I636_02145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I636_02160	COG2354	Protein conserved in bacteria
I636_02165	COG4977	sequence-specific DNA binding
I636_02180	COG0004	ammonium transporteR
I636_02185	COG0405	Gamma-glutamyltransferase
I636_02190	COG2837	iron assimilation
I636_02205	COG0540	Belongs to the ATCase OTCase family
I636_02230	COG0784	Response regulator, receiver
I636_02230	COG5002	protein histidine kinase activity
I636_02230	COG2205	protein histidine kinase activity
I636_02245	COG3300	MHYT domain
I636_02245	COG5001	Diguanylate cyclase
I636_02255	COG1012	belongs to the aldehyde dehydrogenase family
I636_02265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I636_02280	COG0180	Tryptophanyl-tRNA synthetase
I636_02285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I636_02305	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I636_02315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I636_02350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I636_02355	COG0281	malic enzyme
I636_02370	COG0625	glutathione transferase activity
I636_02380	COG0753	catalase activity
I636_02395	COG3300	MHYT domain
I636_02395	COG5001	Diguanylate cyclase
I636_02400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I636_02400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I636_02410	COG0137	argininosuccinate synthase activity
I636_02430	COG1803	Methylglyoxal synthase
I636_02440	COG0745	RESPONSE REGULATOR receiver
I636_02445	COG2205	protein histidine kinase activity
I636_02450	COG2267	carboxylic ester hydrolase activity
I636_02455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I636_02465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I636_02475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I636_02480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_02485	COG4942	peptidase
I636_02490	COG2861	carbohydrate metabolic process
I636_02515	COG1162	GTPase activity
I636_02520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I636_02545	COG0028	Belongs to the TPP enzyme family
I636_02565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I636_02570	COG0805	protein transport
I636_02580	COG0084	hydrolase, TatD family'
I636_02585	COG2203	Gaf domain
I636_02585	COG5001	Diguanylate cyclase
I636_02585	COG3706	GGDEF domain
I636_02585	COG4251	negative regulation of phosphorylation
I636_02595	COG0248	Ppx GppA phosphatase
I636_02600	COG0513	Belongs to the DEAD box helicase family
I636_02605	COG3118	belongs to the thioredoxin family
I636_02610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I636_02620	COG5002	protein histidine kinase activity
I636_02620	COG0784	Response regulator, receiver
I636_02625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I636_02635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I636_02645	COG0783	Belongs to the Dps family
I636_02650	COG2133	pyrroloquinoline quinone binding
I636_02655	COG1506	peptidase
I636_02655	COG4946	Tricorn protease homolog
I636_02655	COG0823	Involved in the tonB-independent uptake of proteins
I636_02665	COG3118	belongs to the thioredoxin family
I636_02680	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I636_02690	COG1012	belongs to the aldehyde dehydrogenase family
I636_02710	COG1757	Na H antiporter
I636_02725	COG3876	Protein conserved in bacteria
I636_02730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I636_02740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I636_02750	COG0346	lactoylglutathione lyase activity
I636_02775	COG2824	Alkylphosphonate utilization operon protein PhnA
I636_02780	COG0454	-acetyltransferase
I636_02810	COG3093	addiction module antidote protein HigA
I636_02825	COG2026	Addiction module toxin, RelE StbE family
I636_02920	COG0183	Belongs to the thiolase family
I636_02925	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_02925	COG1024	Enoyl-CoA hydratase
I636_02935	COG0006	proline dipeptidase activity
I636_02945	COG0142	geranyltranstransferase activity
I636_02975	COG4942	peptidase
I636_02975	COG1388	LysM domain
I636_02980	COG1238	metal cluster binding
I636_02990	COG0585	pseudouridine synthase activity
I636_02995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I636_03005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I636_03015	COG0840	transmembrane signaling receptor activity
I636_03055	COG0494	nUDIX hydrolase
I636_03060	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I636_03065	COG0730	response to heat
I636_03070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I636_03075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I636_03085	COG3706	GGDEF domain
I636_03085	COG0745	RESPONSE REGULATOR receiver
I636_03110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I636_03125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I636_03135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I636_03135	COG1648	precorrin-2 dehydrogenase activity
I636_03140	COG0513	Belongs to the DEAD box helicase family
I636_03160	COG1538	Outer membrane efflux protein
I636_03165	COG0494	nUDIX hydrolase
I636_03175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I636_03180	COG3150	esterase
I636_03185	COG0187	DNA topoisomerase II activity
I636_03195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_03220	COG1509	lysine 2,3-aminomutase activity
I636_03230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I636_03245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I636_03260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I636_03275	COG0271	Belongs to the BolA IbaG family
I636_03295	COG3707	response regulator
I636_03310	COG0659	secondary active sulfate transmembrane transporter activity
I636_03315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I636_03325	COG0243	molybdopterin cofactor binding
I636_03330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I636_03330	COG1648	precorrin-2 dehydrogenase activity
I636_03335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I636_03345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I636_03345	COG1116	anion transmembrane transporter activity
I636_03355	COG1116	anion transmembrane transporter activity
I636_03370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_03375	COG4206	TonB-dependent receptor
I636_03385	COG0348	domain, Protein
I636_03400	COG1960	acyl-CoA dehydrogenase activity
I636_03405	COG1028	Short-chain dehydrogenase reductase Sdr
I636_03415	COG4948	Mandelate Racemase Muconate Lactonizing
I636_03430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_03435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_03455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I636_03460	COG0358	DNA primase activity
I636_03490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I636_03495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I636_03510	COG0537	adenosine 5'-monophosphoramidase activity
I636_03525	COG3135	benzoate transporter
I636_03530	COG1396	sequence-specific DNA binding
I636_03535	COG2974	May be involved in recombination
I636_03540	COG4191	Histidine kinase
I636_03540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_03545	COG0745	RESPONSE REGULATOR receiver
I636_03550	COG5002	protein histidine kinase activity
I636_03575	COG0811	peptide transport
I636_03580	COG0811	peptide transport
I636_03585	COG0848	biopolymer transport protein
I636_03590	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I636_03600	COG3437	response regulator, receiver
I636_03610	COG0318	PFAM AMP-dependent synthetase and ligase
I636_03620	COG2133	pyrroloquinoline quinone binding
I636_03630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_03655	COG0527	aspartate kinase activity
I636_03660	COG0840	transmembrane signaling receptor activity
I636_03665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I636_03670	COG2967	ApaG domain
I636_03680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I636_03685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_03690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I636_03695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I636_03705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_03725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I636_03740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I636_03745	COG3956	TIGRFAM MazG family protein
I636_03770	COG1028	Short-chain dehydrogenase reductase Sdr
I636_03780	COG0318	PFAM AMP-dependent synthetase and ligase
I636_03790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I636_03800	COG0463	Glycosyl transferase, family 2
I636_03820	COG0642	Histidine kinase
I636_03825	COG0745	RESPONSE REGULATOR receiver
I636_03840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I636_03845	COG0723	plastoquinol--plastocyanin reductase activity
I636_03850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I636_03855	COG2857	Cytochrome c1
I636_03860	COG0625	glutathione transferase activity
I636_03865	COG2969	positive regulation of protein catabolic process
I636_03870	COG2239	Acts as a magnesium transporter
I636_03875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I636_03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I636_03895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I636_03900	COG1137	ATPase activity
I636_03905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I636_03915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I636_03930	COG1127	ABC transporter
I636_03935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I636_03940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I636_03945	COG2854	intermembrane phospholipid transfer
I636_03955	COG5007	Belongs to the BolA IbaG family
I636_03965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I636_03970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I636_03980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I636_04015	COG4771	TonB-dependent receptor
I636_04020	COG0697	spore germination
I636_04030	COG2205	protein histidine kinase activity
I636_04030	COG0784	Response regulator, receiver
I636_04055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I636_04065	COG0126	phosphoglycerate kinase activity
I636_04070	COG3588	fructose-bisphosphate aldolase
I636_04080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_04090	COG1538	Outer membrane efflux protein
I636_04095	COG1506	peptidase
I636_04095	COG0823	Involved in the tonB-independent uptake of proteins
I636_04095	COG4946	Tricorn protease homolog
I636_04100	COG0248	Ppx GppA phosphatase
I636_04105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I636_04115	COG0573	inorganic phosphate transmembrane transporter activity
I636_04125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I636_04135	COG0306	phosphate transporter
I636_04145	COG0583	DNA-binding transcription factor activity
I636_04155	COG1272	protein, Hemolysin III
I636_04160	COG1846	Transcriptional regulator
I636_04165	COG1764	response to oxidative stress
I636_04180	COG1739	Uncharacterized protein family UPF0029
I636_04200	COG0420	3'-5' exonuclease activity
I636_04205	COG0419	ATPase involved in DNA repair
I636_04220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I636_04245	COG2986	histidine ammonia-lyase
I636_04275	COG0488	(ABC) transporter
I636_04300	COG0668	transmembrane transport
I636_04350	COG3547	Transposase (IS116 IS110 IS902 family)
I636_04400	COG0582	viral genome integration into host DNA
I636_04405	COG4372	Transposase
I636_04425	COG1484	DNA-dependent DNA replication
I636_04485	COG1346	cytolysis
I636_04515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I636_04525	COG0513	Belongs to the DEAD box helicase family
I636_04535	COG3267	Type II secretory pathway component ExeA
I636_04535	COG3409	Peptidoglycan-binding domain 1 protein
I636_04550	COG0066	3-isopropylmalate dehydratase activity
I636_04560	COG0473	3-isopropylmalate dehydrogenase activity
I636_04565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I636_04585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I636_04600	COG4555	ABC transporter
I636_04605	COG1668	transmembrane transport
I636_04625	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_04630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_04635	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I636_04645	COG1138	Cytochrome C-type biogenesis protein
I636_04650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I636_04665	COG2853	Lipoprotein
I636_04670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I636_04680	COG3104	oligopeptide transport
I636_04710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I636_04725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I636_04730	COG1555	photosystem II stabilization
I636_04730	COG1596	polysaccharide export
I636_04735	COG0473	3-isopropylmalate dehydrogenase activity
I636_04750	COG1611	Belongs to the LOG family
I636_04755	COG3706	GGDEF domain
I636_04755	COG0745	RESPONSE REGULATOR receiver
I636_04760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I636_04760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I636_04815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I636_04820	COG0024	Methionine aminopeptidase
I636_04825	COG0052	Belongs to the universal ribosomal protein uS2 family
I636_04835	COG0528	UMP kinase activity
I636_04845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I636_04850	COG0575	Belongs to the CDS family
I636_04875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I636_04895	COG0587	DNA-directed DNA polymerase activity
I636_04900	COG0825	malonyl-CoA metabolic process
I636_04905	COG0037	tRNA processing
I636_04925	COG0590	tRNA wobble adenosine to inosine editing
I636_04940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I636_04940	COG0047	phosphoribosylformylglycinamidine synthase activity
I636_04950	COG2840	Smr protein MutS2
I636_04990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_04995	COG2197	response regulator
I636_05030	COG5433	transposase activity
I636_05040	COG0784	Response regulator, receiver
I636_05040	COG0835	chemotaxis
I636_05045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I636_05050	COG1815	bacterial-type flagellum-dependent cell motility
I636_05055	COG1558	bacterial-type flagellum-dependent cell motility
I636_05060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I636_05065	COG1749	Flagellar hook protein flgE
I636_05070	COG4787	bacterial-type flagellum-dependent cell motility
I636_05075	COG4786	Flagellar basal body rod
I636_05090	COG3951	Flagellar rod assembly protein muramidase FlgJ
I636_05090	COG1705	Flagellar rod assembly protein muramidase FlgJ
I636_05095	COG1256	bacterial-type flagellum assembly
I636_05110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I636_05125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I636_05140	COG1516	flagellar protein fliS
I636_05155	COG1086	Polysaccharide biosynthesis protein
I636_05160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I636_05170	COG2089	acid synthase
I636_05185	COG1028	Short-chain dehydrogenase reductase Sdr
I636_05190	COG0318	PFAM AMP-dependent synthetase and ligase
I636_05235	COG1660	Displays ATPase and GTPase activities
I636_05240	COG1216	Glycosyl transferase, family 2
I636_05255	COG1083	cytidylyl-transferase
I636_05265	COG2204	response regulator
I636_05270	COG3852	Histidine kinase
I636_05275	COG2204	response regulator
I636_05280	COG1677	Flagellar hook-basal body complex protein FliE
I636_05285	COG1766	The M ring may be actively involved in energy transduction
I636_05290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I636_05340	COG1987	bacterial-type flagellum assembly
I636_05355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I636_05365	COG0455	bacterial-type flagellum organization
I636_05380	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I636_05385	COG2198	Histidine kinase
I636_05385	COG0643	Histidine kinase
I636_05395	COG1192	Involved in chromosome partitioning
I636_05405	COG0835	chemotaxis
I636_05420	COG1410	methionine synthase
I636_05420	COG0646	methionine synthase
I636_05425	COG1410	methionine synthase
I636_05425	COG0646	methionine synthase
I636_05435	COG3123	guanosine phosphorylase activity
I636_05440	COG0583	DNA-binding transcription factor activity
I636_05445	COG0583	DNA-binding transcription factor activity
I636_05455	COG0288	reversible hydration of carbon dioxide
I636_05460	COG0659	secondary active sulfate transmembrane transporter activity
I636_05475	COG3590	peptidase
I636_05485	COG2137	regulation of response to DNA damage stimulus
I636_05490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I636_05505	COG0511	ligase activity, forming carbon-carbon bonds
I636_05505	COG5016	pyruvate
I636_05510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I636_05515	COG4172	Belongs to the ABC transporter superfamily
I636_05525	COG4171	peptide transport system, permease
I636_05530	COG4168	peptide transport system, permease
I636_05535	COG0747	negative chemotaxis
I636_05540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I636_05545	COG1842	Phage shock protein A
I636_05575	COG0625	glutathione transferase activity
I636_05580	COG1522	sequence-specific DNA binding
I636_05650	COG0811	peptide transport
I636_05655	COG0811	peptide transport
I636_05660	COG0848	biopolymer transport protein
I636_05675	COG1444	tRNA N-acetyltransferase activity
I636_05710	COG0456	acetyltransferase
I636_05725	COG0583	DNA-binding transcription factor activity
I636_05730	COG2814	Major facilitator Superfamily
I636_05735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_05740	COG0656	L-ascorbic acid biosynthetic process
I636_05760	COG1846	Transcriptional regulator
I636_05775	COG3620	sequence-specific DNA binding
I636_05780	COG3550	peptidyl-serine autophosphorylation
I636_05810	COG0668	transmembrane transport
I636_05820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I636_05840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I636_05920	COG0789	Transcriptional regulator
I636_05935	COG1283	sodium-dependent phosphate transmembrane transporter activity
I636_05990	COG0789	Transcriptional regulator
I636_06010	COG0789	Transcriptional regulator
I636_06015	COG0640	Transcriptional regulator
I636_06020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_06030	COG1230	cation diffusion facilitator family transporter
I636_06060	COG1538	Outer membrane efflux protein
I636_06095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I636_06110	COG0681	Belongs to the peptidase S26 family
I636_06130	COG1074	ATP-dependent DNA helicase activity
I636_06140	COG1404	Belongs to the peptidase S8 family
I636_06145	COG0464	growth
I636_06165	COG0629	single-stranded DNA binding
I636_06185	COG0714	Associated with various cellular activities
I636_06210	COG2003	Belongs to the UPF0758 family
I636_06230	COG0583	DNA-binding transcription factor activity
I636_06320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I636_06330	COG3706	GGDEF domain
I636_06365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I636_06370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I636_06375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I636_06380	COG0564	pseudouridine synthase activity
I636_06390	COG0612	Peptidase, M16
I636_06395	COG2918	glutathione biosynthetic process
I636_06420	COG2840	Smr protein MutS2
I636_06425	COG2890	protein-(glutamine-N5) methyltransferase activity
I636_06440	COG2719	SpoVR family
I636_06445	COG2718	Belongs to the UPF0229 family
I636_06450	COG2766	serine protein kinase
I636_06460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I636_06465	COG4771	TonB-dependent receptor
I636_06490	COG0450	alkyl hydroperoxide reductase
I636_06495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I636_06500	COG2885	chlorophyll binding
I636_06505	COG0584	glycerophosphoryl diester phosphodiesterase
I636_06510	COG0346	lactoylglutathione lyase activity
I636_06515	COG1278	Cold shock
I636_06530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I636_06535	COG4660	Part of a membrane complex involved in electron transport
I636_06540	COG4659	FMN binding
I636_06545	COG4658	electron transport chain
I636_06550	COG4656	Part of a membrane complex involved in electron transport
I636_06555	COG2878	Part of a membrane complex involved in electron transport
I636_06565	COG0534	Mate efflux family protein
I636_06570	COG0556	nucleotide-excision repair
I636_06585	COG0602	queuosine metabolic process
I636_06595	COG0367	asparagine synthase
I636_06620	COG3273	potassium ion transport
I636_06620	COG0471	metal ion transport
I636_06635	COG0529	Catalyzes the synthesis of activated sulfate
I636_06640	COG0175	sulfate reduction
I636_06665	COG3273	potassium ion transport
I636_06665	COG0471	metal ion transport
I636_06680	COG0529	Catalyzes the synthesis of activated sulfate
I636_06685	COG0175	sulfate reduction
I636_06690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_06695	COG3706	GGDEF domain
I636_06720	COG2304	oxidoreductase activity
I636_06740	COG0714	Associated with various cellular activities
I636_06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_06750	COG1024	Enoyl-CoA hydratase
I636_06770	COG1025	Belongs to the peptidase M16 family
I636_06775	COG2062	phosphohistidine phosphatase, SixA
I636_06785	COG4536	flavin adenine dinucleotide binding
I636_06790	COG4137	Cytochrome C assembly protein
I636_06795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I636_06840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_06845	COG1132	(ABC) transporter
I636_06860	COG0228	four-way junction DNA binding
I636_06865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I636_06870	COG0336	Belongs to the RNA methyltransferase TrmD family
I636_06875	COG0335	large ribosomal subunit rRNA binding
I636_06880	COG2860	membrane
I636_06890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I636_06895	COG1605	Chorismate mutase
I636_06895	COG0287	Prephenate dehydrogenase
I636_06900	COG1605	Chorismate mutase
I636_06900	COG0077	Prephenate dehydratase
I636_06910	COG0023	Translation Initiation Factor
I636_06940	COG2205	protein histidine kinase activity
I636_06950	COG2204	response regulator
I636_06975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I636_06980	COG0494	nUDIX hydrolase
I636_06985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I636_06995	COG2255	four-way junction helicase activity
I636_07000	COG0824	Thioesterase
I636_07005	COG0811	peptide transport
I636_07020	COG0823	Involved in the tonB-independent uptake of proteins
I636_07025	COG2885	chlorophyll binding
I636_07030	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I636_07040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I636_07055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I636_07070	COG4667	esterase of the alpha-beta hydrolase superfamily
I636_07075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I636_07085	COG2205	protein histidine kinase activity
I636_07085	COG0784	Response regulator, receiver
I636_07105	COG3038	cytochrome b561
I636_07125	COG0583	DNA-binding transcription factor activity
I636_07130	COG1451	nucleotide metabolic process
I636_07140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_07150	COG1309	transcriptional regulator
I636_07155	COG4774	siderophore transport
I636_07175	COG3706	GGDEF domain
I636_07185	COG3008	intermembrane lipid transfer
I636_07185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I636_07190	COG2995	paraquat-inducible protein a
I636_07205	COG0017	Asparaginyl-tRNA synthetase
I636_07220	COG0189	ligase activity
I636_07250	COG0156	8-amino-7-oxononanoate synthase activity
I636_07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_07265	COG3340	Belongs to the peptidase S51 family
I636_07270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I636_07275	COG4139	cobalamin transport
I636_07280	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I636_07285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I636_07300	COG5265	(ABC) transporter
I636_07305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I636_07315	COG0745	RESPONSE REGULATOR receiver
I636_07320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I636_07340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_07355	COG2755	lipolytic protein G-D-S-L family
I636_07360	COG4181	ATPase activity
I636_07365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I636_07370	COG1090	epimerase
I636_07375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I636_07380	COG0628	permease
I636_07390	COG0745	RESPONSE REGULATOR receiver
I636_07405	COG2350	Protein conserved in bacteria
I636_07410	COG0159	tryptophan synthase activity
I636_07420	COG0135	phosphoribosylanthranilate isomerase activity
I636_07420	COG0134	indole-3-glycerol-phosphate synthase activity
I636_07425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I636_07435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I636_07440	COG0613	PHP domain protein
I636_07445	COG0009	L-threonylcarbamoyladenylate synthase
I636_07450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I636_07455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I636_07465	COG0656	L-ascorbic acid biosynthetic process
I636_07470	COG0110	maltose O-acetyltransferase activity
I636_07480	COG2733	membrane
I636_07505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_07510	COG0500	methyltransferase
I636_07515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_07520	COG0497	DNA recombination
I636_07525	COG0783	Belongs to the Dps family
I636_07535	COG1454	alcohol dehydrogenase
I636_07540	COG1028	Short-chain dehydrogenase reductase Sdr
I636_07550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I636_07555	COG2610	gluconate transmembrane transporter activity
I636_07560	COG4771	TonB-dependent receptor
I636_07570	COG0784	Response regulator, receiver
I636_07570	COG2198	Histidine kinase
I636_07570	COG2205	protein histidine kinase activity
I636_07575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I636_07585	COG0484	heat shock protein binding
I636_07590	COG3909	cytochrome
I636_07595	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I636_07610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I636_07615	COG0505	Belongs to the CarA family
I636_07620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I636_07625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I636_07645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I636_07650	COG0857	belongs to the CobB CobQ family
I636_07650	COG0280	phosphate acetyltransferase
I636_07665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I636_07670	COG4535	Mg2 and Co2 transporter CorC
I636_07680	COG1702	phosphate starvation-inducible protein PhoH
I636_07690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I636_07735	COG1607	acyl-coa hydrolase
I636_07740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I636_07750	COG1115	amino acid carrier protein
I636_07755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I636_07760	COG0012	GTP binding
I636_07780	COG1064	alcohol dehydrogenase
I636_07795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I636_07800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I636_07805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I636_07810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I636_07820	COG2890	protein-(glutamine-N5) methyltransferase activity
I636_07825	COG3437	response regulator, receiver
I636_07825	COG0784	Response regulator, receiver
I636_07830	COG3094	Invasion gene expression up-regulator, SirB
I636_07845	COG0583	DNA-binding transcription factor activity
I636_07855	COG2363	Small membrane protein
I636_07870	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I636_07875	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I636_07880	COG0515	serine threonine protein kinase
I636_07885	COG2116	formate transmembrane transporter activity
I636_07900	COG0714	Associated with various cellular activities
I636_07905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I636_07910	COG0033	Phosphoglucomutase
I636_07915	COG0058	SHG alpha-glucan phosphorylase activity
I636_07925	COG2988	succinylglutamate desuccinylase activity
I636_07960	COG1393	Belongs to the ArsC family
I636_07985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I636_08015	COG3300	MHYT domain
I636_08015	COG5001	Diguanylate cyclase
I636_08040	COG1733	regulation of RNA biosynthetic process
I636_08045	COG5002	protein histidine kinase activity
I636_08045	COG3447	MASE1 domain protein
I636_08045	COG5001	Diguanylate cyclase
I636_08055	COG0402	S-adenosylhomocysteine deaminase activity
I636_08060	COG2351	hydroxyisourate hydrolase activity
I636_08075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_08090	COG1309	transcriptional regulator
I636_08105	COG2252	PERMEase
I636_08110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I636_08125	COG5001	Diguanylate cyclase
I636_08125	COG4251	negative regulation of phosphorylation
I636_08125	COG2203	Gaf domain
I636_08125	COG3706	GGDEF domain
I636_08130	COG3706	GGDEF domain
I636_08130	COG2203	Gaf domain
I636_08130	COG5001	Diguanylate cyclase
I636_08130	COG4251	negative regulation of phosphorylation
I636_08135	COG2205	protein histidine kinase activity
I636_08135	COG0784	Response regulator, receiver
I636_08150	COG2233	PERMEase
I636_08165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I636_08170	COG0730	response to heat
I636_08215	COG1028	Short-chain dehydrogenase reductase Sdr
I636_08230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I636_08245	COG0662	Cupin 2, conserved barrel domain protein
I636_08245	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I636_08250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I636_08260	COG1596	polysaccharide export
I636_08265	COG0489	protein tyrosine kinase activity
I636_08270	COG4464	protein tyrosine phosphatase activity
I636_08330	COG1216	Glycosyl transferase, family 2
I636_08345	COG1215	transferase activity, transferring glycosyl groups
I636_08350	COG0438	transferase activity, transferring glycosyl groups
I636_08360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I636_08395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_08395	COG0072	phenylalanine-tRNA ligase activity
I636_08410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I636_08420	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_08425	COG2096	Adenosyltransferase
I636_08435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I636_08445	COG4591	ABC-type transport system involved in lipoprotein release permease component
I636_08470	COG0708	Exodeoxyribonuclease III
I636_08505	COG2814	Major facilitator Superfamily
I636_08550	COG1024	Enoyl-CoA hydratase
I636_08555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I636_08560	COG1960	acyl-CoA dehydrogenase activity
I636_08565	COG0789	Transcriptional regulator
I636_08570	COG0183	Belongs to the thiolase family
I636_08585	COG3706	GGDEF domain
I636_08595	COG2925	Exonuclease
I636_08650	COG1643	Atp-dependent helicase
I636_08670	COG0604	alcohol dehydrogenase
I636_08670	COG3321	synthase
I636_08675	COG0328	RNA-DNA hybrid ribonuclease activity
I636_08680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I636_08690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I636_08700	COG4591	ABC-type transport system involved in lipoprotein release permease component
I636_08715	COG3724	N-succinylarginine dihydrolase activity
I636_08725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I636_08740	COG0746	molybdenum cofactor guanylyltransferase activity
I636_08745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I636_08750	COG0243	molybdopterin cofactor binding
I636_08755	COG2153	protein acetylation
I636_08770	COG1530	ribonuclease E activity
I636_08785	COG0424	maF-like protein
I636_08790	COG1399	metal-binding, possibly nucleic acid-binding protein
I636_08800	COG0416	fatty acid biosynthetic process
I636_08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I636_08810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I636_08820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I636_08825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I636_08835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I636_08850	COG0084	hydrolase, TatD family'
I636_08860	COG0702	epimerase
I636_08865	COG3706	GGDEF domain
I636_08865	COG0745	RESPONSE REGULATOR receiver
I636_08885	COG1028	Short-chain dehydrogenase reductase Sdr
I636_08890	COG0596	Alpha beta hydrolase
I636_08900	COG0183	Belongs to the thiolase family
I636_08905	COG1960	acyl-CoA dehydrogenase activity
I636_08925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I636_08935	COG0246	Mannitol dehydrogenase
I636_08960	COG0668	transmembrane transport
I636_08965	COG4771	TonB-dependent receptor
I636_08980	COG3437	response regulator, receiver
I636_08990	COG0195	Participates in both transcription termination and antitermination
I636_09005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I636_09020	COG1187	pseudouridine synthase activity
I636_09030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_09030	COG3153	acetyltransferase
I636_09070	COG0450	alkyl hydroperoxide reductase
I636_09115	COG1032	radical SAM domain protein
I636_09130	COG4771	TonB-dependent receptor
I636_09135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_09145	COG4134	Bacterial extracellular solute-binding protein
I636_09155	COG4136	ATPase activity
I636_09160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I636_09185	COG5001	Diguanylate cyclase
I636_09185	COG4251	negative regulation of phosphorylation
I636_09185	COG2203	Gaf domain
I636_09185	COG3706	GGDEF domain
I636_09210	COG1902	pentaerythritol trinitrate reductase activity
I636_09220	COG2867	negative regulation of translational initiation
I636_09225	COG2914	Belongs to the UPF0125 (RnfH) family
I636_09235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_09240	COG4771	TonB-dependent receptor
I636_09245	COG0457	Tetratricopeptide repeat
I636_09260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I636_09260	COG0574	Belongs to the PEP-utilizing enzyme family
I636_09300	COG2850	peptidyl-arginine hydroxylation
I636_09310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I636_09315	COG2915	High frequency lysogenization protein hflD homolog
I636_09320	COG0482	sulfurtransferase activity
I636_09325	COG1187	pseudouridine synthase activity
I636_09335	COG1278	Cold shock
I636_09340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I636_09345	COG0542	response to heat
I636_09350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I636_09355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I636_09360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I636_09365	COG0492	ferredoxin-NADP+ reductase activity
I636_09370	COG3092	negative regulation of chromosome organization
I636_09375	COG3091	SprT-like family
I636_09380	COG0616	signal peptide processing
I636_09395	COG0778	Nitroreductase
I636_09405	COG0252	asparaginase activity
I636_09410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I636_09415	COG0321	lipoyl(octanoyl) transferase activity
I636_09420	COG2921	Belongs to the UPF0250 family
I636_09425	COG1686	Belongs to the peptidase S11 family
I636_09430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I636_09435	COG0772	Belongs to the SEDS family
I636_09440	COG0768	penicillin binding
I636_09445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I636_09450	COG0799	negative regulation of ribosome biogenesis
I636_09460	COG1466	dna polymerase III delta subunit
I636_09465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I636_09470	COG0495	leucyl-tRNA aminoacylation
I636_09485	COG1067	ATP-dependent peptidase activity
I636_09490	COG0596	Alpha beta hydrolase
I636_09495	COG3706	GGDEF domain
I636_09505	COG1534	Rna-binding protein
I636_09510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I636_09515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I636_09520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I636_09525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I636_09530	COG0149	triose-phosphate isomerase activity
I636_09535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I636_09540	COG5001	Diguanylate cyclase
I636_09540	COG3300	MHYT domain
I636_09560	COG1597	lipid kinase activity
I636_09560	COG1803	Methylglyoxal synthase
I636_09570	COG1028	Short-chain dehydrogenase reductase Sdr
I636_09575	COG0561	phosphatase activity
I636_09590	COG2801	Transposase and inactivated derivatives
I636_09615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_09640	COG1185	polyribonucleotide nucleotidyltransferase activity
I636_09660	COG3547	Transposase (IS116 IS110 IS902 family)
I636_09745	COG4372	Transposase
I636_09780	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I636_09785	COG1196	nuclear chromosome segregation
I636_09795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I636_09810	COG1132	(ABC) transporter
I636_09815	COG1663	tetraacyldisaccharide 4'-kinase activity
I636_09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I636_09855	COG0435	Glutathione S-transferase
I636_09860	COG1741	Belongs to the pirin family
I636_09865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I636_09875	COG0372	Belongs to the citrate synthase family
I636_09880	COG2009	succinate dehydrogenase
I636_09885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I636_09890	COG1053	succinate dehydrogenase
I636_09895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I636_09900	COG0567	Dehydrogenase, E1 component
I636_09905	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_09940	COG4667	esterase of the alpha-beta hydrolase superfamily
I636_09960	COG0366	Alpha amylase catalytic
I636_09985	COG1028	Short-chain dehydrogenase reductase Sdr
I636_09990	COG2267	carboxylic ester hydrolase activity
I636_10000	COG0616	signal peptide processing
I636_10020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_10025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I636_10030	COG0386	Belongs to the glutathione peroxidase family
I636_10035	COG2084	Dehydrogenase
I636_10045	COG1960	acyl-CoA dehydrogenase activity
I636_10050	COG1024	Enoyl-CoA hydratase
I636_10060	COG2226	methyltransferase
I636_10065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I636_10070	COG3083	sulfuric ester hydrolase activity
I636_10075	COG3082	Protein of unknown function (DUF1414)
I636_10080	COG3081	Nucleoid-associated protein
I636_10110	COG3275	phosphorelay sensor kinase activity
I636_10115	COG3279	Response regulator of the LytR AlgR family
I636_10120	COG0205	6-phosphofructokinase activity
I636_10135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_10150	COG2205	protein histidine kinase activity
I636_10150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_10170	COG0513	Belongs to the DEAD box helicase family
I636_10180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I636_10185	COG0583	DNA-binding transcription factor activity
I636_10205	COG1760	l-serine dehydratase
I636_10230	COG1322	Protein conserved in bacteria
I636_10235	COG1404	Belongs to the peptidase S8 family
I636_10240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I636_10245	COG0022	dehydrogenase e1 component
I636_10255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I636_10260	COG0515	serine threonine protein kinase
I636_10265	COG1946	Acyl-CoA thioesterase
I636_10275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I636_10285	COG1956	GAF domain-containing protein
I636_10300	COG0793	Belongs to the peptidase S41A family
I636_10305	COG0733	neurotransmitter:sodium symporter activity
I636_10315	COG0308	aminopeptidase N
I636_10345	COG2902	Dehydrogenase
I636_10350	COG0167	dihydroorotate dehydrogenase activity
I636_10375	COG3130	regulation of translation
I636_10380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I636_10390	COG0415	Belongs to the DNA photolyase family
I636_10395	COG0415	Belongs to the DNA photolyase family
I636_10400	COG0415	Belongs to the DNA photolyase family
I636_10405	COG3046	protein related to deoxyribodipyrimidine photolyase
I636_10430	COG2193	ferroxidase activity
I636_10440	COG3278	Belongs to the heme-copper respiratory oxidase family
I636_10455	COG2010	Cytochrome c
I636_10480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I636_10485	COG0589	response to stress
I636_10490	COG0037	tRNA processing
I636_10495	COG1752	Esterase of the alpha-beta hydrolase superfamily
I636_10515	COG1280	lysine exporter protein (LysE YggA)
I636_10520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I636_10525	COG2897	thiosulfate sulfurtransferase activity
I636_10530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I636_10545	COG0322	excinuclease ABC activity
I636_10550	COG2197	response regulator
I636_10555	COG0436	Aminotransferase
I636_10570	COG2259	Doxx family
I636_10575	COG0583	DNA-binding transcription factor activity
I636_10590	COG0670	Belongs to the BI1 family
I636_10595	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I636_10610	COG2920	part of a sulfur-relay system
I636_10640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I636_10650	COG0531	amino acid
I636_10650	COG1674	ftsk spoiiie
I636_10660	COG0686	Belongs to the AlaDH PNT family
I636_10665	COG0284	orotidine-5'-phosphate decarboxylase activity
I636_10670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I636_10685	COG0776	regulation of translation
I636_10690	COG0539	negative regulation of cytoplasmic translation
I636_10695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I636_10700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I636_10705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I636_10715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I636_10720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I636_10725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I636_10730	COG0633	Ferredoxin
I636_10760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I636_10765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I636_10775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I636_10785	COG4783	chaperone-mediated protein folding
I636_10795	COG1393	Belongs to the ArsC family
I636_10810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I636_10825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I636_10835	COG1960	acyl-CoA dehydrogenase activity
I636_10860	COG0572	uridine kinase
I636_10865	COG3769	mannosylglycerate metabolic process
I636_10870	COG1215	transferase activity, transferring glycosyl groups
I636_10875	COG0366	Alpha amylase catalytic
I636_10885	COG0303	'Molybdopterin
I636_10890	COG0534	Mate efflux family protein
I636_10905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I636_10910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I636_10965	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I636_10985	COG3547	Transposase (IS116 IS110 IS902 family)
I636_11010	COG0405	Gamma-glutamyltransferase
I636_11015	COG1024	Enoyl-CoA hydratase
I636_11060	COG1448	Aminotransferase
I636_11070	COG1671	Belongs to the UPF0178 family
I636_11075	COG1028	Short-chain dehydrogenase reductase Sdr
I636_11080	COG1028	Short-chain dehydrogenase reductase Sdr
I636_11085	COG1960	acyl-CoA dehydrogenase activity
I636_11090	COG2207	Transcriptional regulator
I636_11090	COG0662	Cupin 2, conserved barrel domain protein
I636_11105	COG1505	serine-type exopeptidase activity
I636_11115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_11145	COG0596	Alpha beta hydrolase
I636_11155	COG0716	FMN binding
I636_11165	COG0735	belongs to the Fur family
I636_11175	COG1984	allophanate hydrolase subunit 2
I636_11180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I636_11185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I636_11190	COG2996	Protein conserved in bacteria
I636_11195	COG1765	OsmC-like protein
I636_11200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I636_11225	COG0436	Aminotransferase
I636_11230	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_11235	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_11245	COG2010	Cytochrome c
I636_11245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_11250	COG2080	2 iron, 2 sulfur cluster binding
I636_11275	COG1073	alpha beta
I636_11280	COG2207	Transcriptional regulator
I636_11290	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_11295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I636_11320	COG3012	SEC-C Motif Domain Protein
I636_11325	COG0604	alcohol dehydrogenase
I636_11335	COG1960	acyl-CoA dehydrogenase activity
I636_11345	COG4771	TonB-dependent receptor
I636_11365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I636_11370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I636_11390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I636_11395	COG0315	cyclic pyranopterin monophosphate synthase activity
I636_11400	COG0521	Mo-molybdopterin cofactor biosynthetic process
I636_11415	COG2161	toxin-antitoxin pair type II binding
I636_11420	COG4115	mRNA cleavage
I636_11435	COG0436	Aminotransferase
I636_11440	COG3268	Saccharopine dehydrogenase
I636_11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I636_11460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I636_11465	COG4206	TonB-dependent receptor
I636_11475	COG5006	permease, DMT superfamily
I636_11490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I636_11495	COG1074	ATP-dependent DNA helicase activity
I636_11500	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I636_11520	COG1022	Amp-dependent synthetase and ligase
I636_11525	COG3706	GGDEF domain
I636_11525	COG5001	Diguanylate cyclase
I636_11525	COG4251	negative regulation of phosphorylation
I636_11525	COG2203	Gaf domain
I636_11545	COG0583	DNA-binding transcription factor activity
I636_11565	COG0640	Transcriptional regulator
I636_11585	COG2204	response regulator
I636_11595	COG4251	negative regulation of phosphorylation
I636_11600	COG0784	Response regulator, receiver
I636_11605	COG2205	protein histidine kinase activity
I636_11605	COG0784	Response regulator, receiver
I636_11630	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I636_11655	COG3139	Protein of unknown function (DUF1315)
I636_11670	COG1115	amino acid carrier protein
I636_11675	COG2866	Carboxypeptidase
I636_11695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I636_11705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I636_11710	COG1640	4-alpha-glucanotransferase
I636_11715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I636_11720	COG0676	glucose-6-phosphate 1-epimerase activity
I636_11725	COG0800	Aldolase
I636_11735	COG0129	dihydroxy-acid dehydratase activity
I636_11745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I636_11750	COG1737	Transcriptional regulator
I636_11755	COG0469	pyruvate kinase activity
I636_11770	COG1960	acyl-CoA dehydrogenase activity
I636_11790	COG0490	domain, Protein
I636_11790	COG0471	metal ion transport
I636_11800	COG0800	Aldolase
I636_11810	COG0129	dihydroxy-acid dehydratase activity
I636_11820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I636_11825	COG1737	Transcriptional regulator
I636_11830	COG0469	pyruvate kinase activity
I636_11835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_11855	COG2823	Periplasmic or secreted lipoprotein
I636_11885	COG3665	Urea carboxylase-associated protein
I636_11925	COG2356	endonuclease I
I636_11930	COG0840	transmembrane signaling receptor activity
I636_11945	COG0583	DNA-binding transcription factor activity
I636_11950	COG1979	alcohol dehydrogenase
I636_11965	COG3437	response regulator, receiver
I636_11965	COG0784	Response regulator, receiver
I636_11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_11970	COG4191	Histidine kinase
I636_12100	COG0471	metal ion transport
I636_12110	COG0489	protein tyrosine kinase activity
I636_12115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_12115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I636_12120	COG0668	transmembrane transport
I636_12125	COG2226	methyltransferase
I636_12130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_12135	COG0741	lytic transglycosylase activity
I636_12135	COG1388	LysM domain
I636_12160	COG0215	cysteine-tRNA ligase activity
I636_12165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I636_12170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I636_12180	COG2268	Band 7 protein
I636_12195	COG1733	regulation of RNA biosynthetic process
I636_12200	COG0604	alcohol dehydrogenase
I636_12205	COG0753	catalase activity
I636_12210	COG0604	alcohol dehydrogenase
I636_12215	COG0583	DNA-binding transcription factor activity
I636_12250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I636_12255	COG1286	toxin biosynthetic process
I636_12260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I636_12265	COG0285	dihydrofolate synthase activity
I636_12285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I636_12290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I636_12310	COG3609	addiction module antidote protein, CC2985 family
I636_12320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I636_12325	COG0318	PFAM AMP-dependent synthetase and ligase
I636_12335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I636_12335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I636_12370	COG0789	Transcriptional regulator
I636_12375	COG0604	alcohol dehydrogenase
I636_12400	COG1028	Short-chain dehydrogenase reductase Sdr
I636_12405	COG1119	ATPase activity
I636_12410	COG2031	fatty acid transporter
I636_12415	COG0784	Response regulator, receiver
I636_12415	COG2205	protein histidine kinase activity
I636_12415	COG5002	protein histidine kinase activity
I636_12425	COG0612	Peptidase, M16
I636_12440	COG3101	peptidyl-lysine hydroxylation
I636_12470	COG1902	pentaerythritol trinitrate reductase activity
I636_12470	COG0446	pyridine nucleotide-disulphide oxidoreductase
I636_12495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I636_12505	COG4399	Belongs to the UPF0754 family
I636_12530	COG1770	oligopeptidase
I636_12535	COG2186	Transcriptional regulator
I636_12545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I636_12550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I636_12560	COG2983	Belongs to the UPF0260 family
I636_12565	COG0179	Fumarylacetoacetate (FAA) hydrolase
I636_12580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I636_12585	COG0318	PFAM AMP-dependent synthetase and ligase
I636_12590	COG2267	carboxylic ester hydrolase activity
I636_12605	COG1214	PFAM Peptidase M22, glycoprotease
I636_12610	COG1199	ATP-dependent helicase activity
I636_12660	COG4771	TonB-dependent receptor
I636_12670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I636_12675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I636_12680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I636_12685	COG0131	Imidazoleglycerol-phosphate dehydratase
I636_12685	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I636_12690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I636_12705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I636_12705	COG0140	phosphoribosyl-ATP diphosphatase activity
I636_12720	COG2116	formate transmembrane transporter activity
I636_12725	COG0612	Peptidase, M16
I636_12760	COG0326	Molecular chaperone. Has ATPase activity
I636_12765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I636_12795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I636_12805	COG3220	belongs to the UPF0276 family
I636_12815	COG1136	(ABC) transporter
I636_12815	COG0577	efflux transmembrane transporter activity
I636_12825	COG2203	Gaf domain
I636_12825	COG5001	Diguanylate cyclase
I636_12825	COG4251	negative regulation of phosphorylation
I636_12825	COG3706	GGDEF domain
I636_12830	COG1183	phosphatidylcholine synthase activity
I636_12850	COG0277	FAD linked oxidase domain protein
I636_12855	COG0542	response to heat
I636_12865	COG0564	pseudouridine synthase activity
I636_12880	COG1595	DNA-templated transcription, initiation
I636_12895	COG4221	oxidoreductase activity
I636_12910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I636_12920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I636_12930	COG0142	geranyltranstransferase activity
I636_12940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I636_12945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I636_12955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I636_12970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I636_12970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I636_12990	COG0488	(ABC) transporter
I636_13000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I636_13010	COG0560	Phosphoserine phosphatase
I636_13020	COG0084	hydrolase, TatD family'
I636_13035	COG0571	ribonuclease III activity
I636_13040	COG0681	Belongs to the peptidase S26 family
I636_13065	COG1595	DNA-templated transcription, initiation
I636_13075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I636_13090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I636_13170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I636_13175	COG1047	Peptidyl-prolyl cis-trans
I636_13185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I636_13190	COG0196	riboflavin kinase activity
I636_13195	COG0728	peptidoglycan biosynthetic process
I636_13200	COG0268	Binds directly to 16S ribosomal RNA
I636_13220	COG0385	Bile acid
I636_13250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_13255	COG0776	regulation of translation
I636_13265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I636_13270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I636_13275	COG0740	serine-type endopeptidase activity
I636_13280	COG0544	peptidyl-prolyl cis-trans isomerase activity
I636_13290	COG1234	tRNA 3'-trailer cleavage
I636_13300	COG0123	including yeast histone deacetylase and acetoin utilization protein
I636_13315	COG0517	IMP dehydrogenase activity
I636_13315	COG0516	GMP reductase activity
I636_13320	COG1570	exodeoxyribonuclease VII activity
I636_13340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I636_13345	COG2976	Protein conserved in bacteria
I636_13370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I636_13380	COG2166	iron-sulfur cluster assembly
I636_13395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I636_13400	COG0719	Fe-S assembly protein
I636_13405	COG0396	ATPase activity
I636_13410	COG0719	Fe-S assembly protein
I636_13415	COG1104	cysteine desulfurase activity
I636_13425	COG2072	flavoprotein involved in K transport
I636_13430	COG1045	serine acetyltransferase
I636_13435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I636_13440	COG0483	inositol monophosphate 1-phosphatase activity
I636_13455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I636_13460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I636_13465	COG1862	Preprotein translocase
I636_13470	COG0343	queuine tRNA-ribosyltransferase activity
I636_13490	COG1842	Phage shock protein A
I636_13495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I636_13515	COG0754	glutathionylspermidine amidase activity
I636_13545	COG2066	Belongs to the glutaminase family
I636_13550	COG1785	Belongs to the alkaline phosphatase family
I636_13605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I636_13625	COG0438	transferase activity, transferring glycosyl groups
I636_13645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I636_13650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I636_13680	COG2755	lipolytic protein G-D-S-L family
I636_13680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I636_13685	COG0367	asparagine synthase
I636_13690	COG0438	transferase activity, transferring glycosyl groups
I636_13700	COG2244	polysaccharide biosynthetic process
I636_13730	COG0367	asparagine synthase
I636_13765	COG0489	protein tyrosine kinase activity
I636_13775	COG3267	Type II secretory pathway component ExeA
I636_13775	COG3409	Peptidoglycan-binding domain 1 protein
I636_13830	COG1560	Kdo2-lipid A biosynthetic process
I636_13845	COG1960	acyl-CoA dehydrogenase activity
I636_13860	COG3300	MHYT domain
I636_13860	COG5001	Diguanylate cyclase
I636_13865	COG1435	thymidine kinase activity
I636_13875	COG1609	Transcriptional regulator
I636_13880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I636_13910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I636_13915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I636_13920	COG1250	3-hydroxyacyl-CoA dehydrogenase
I636_13920	COG1024	Enoyl-CoA hydratase
I636_13935	COG1012	belongs to the aldehyde dehydrogenase family
I636_13955	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I636_13980	COG1960	acyl-CoA dehydrogenase activity
I636_14010	COG0745	RESPONSE REGULATOR receiver
I636_14015	COG2205	protein histidine kinase activity
I636_14055	COG2080	2 iron, 2 sulfur cluster binding
I636_14060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I636_14065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I636_14085	COG1028	Short-chain dehydrogenase reductase Sdr
I636_14090	COG4221	oxidoreductase activity
I636_14095	COG0693	protein deglycase activity
I636_14100	COG1295	ribonuclease BN
I636_14110	COG4681	YaeQ
I636_14140	COG2814	Major facilitator Superfamily
I636_14155	COG0514	ATP-dependent DNA helicase (RecQ)
I636_14185	COG4251	negative regulation of phosphorylation
I636_14190	COG2133	pyrroloquinoline quinone binding
I636_14195	COG3609	addiction module antidote protein, CC2985 family
I636_14230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I636_14240	COG0330	HflC and HflK could
I636_14335	COG4772	TonB-dependent receptor
I636_14370	COG1230	cation diffusion facilitator family transporter
I636_14380	COG4372	Transposase
I636_14395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_14400	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_14405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I636_14410	COG2186	Transcriptional regulator
I636_14420	COG3023	N-Acetylmuramoyl-L-alanine amidase
I636_14425	COG3577	Aspartyl protease
I636_14430	COG0157	Belongs to the NadC ModD family
I636_14440	COG1459	type II secretion system
I636_14445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I636_14455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I636_14465	COG3608	succinylglutamate desuccinylase aspartoacylase
I636_14470	COG0494	nUDIX hydrolase
I636_14480	COG0739	heme binding
I636_14485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I636_14490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I636_14495	COG0849	cell division
I636_14500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I636_14505	COG1181	Belongs to the D-alanine--D-alanine ligase family
I636_14510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I636_14520	COG0772	Belongs to the SEDS family
I636_14525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I636_14535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I636_14540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I636_14545	COG0768	penicillin binding
I636_14550	COG3116	cell division
I636_14560	COG2001	Belongs to the MraZ family
I636_14610	COG0678	peroxiredoxin activity
I636_14610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I636_14625	COG3706	GGDEF domain
I636_14635	COG2204	response regulator
I636_14640	COG2205	protein histidine kinase activity
I636_14640	COG0784	Response regulator, receiver
I636_14670	COG0668	transmembrane transport
I636_14675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I636_14680	COG0189	ligase activity
I636_14685	COG1678	Uncharacterized ACR, COG1678
I636_14690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I636_14715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I636_14720	COG0762	integral membrane protein
I636_14730	COG0446	pyridine nucleotide-disulphide oxidoreductase
I636_14730	COG1902	pentaerythritol trinitrate reductase activity
I636_14745	COG0625	glutathione transferase activity
I636_14755	COG1764	response to oxidative stress
I636_14760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I636_14775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I636_14785	COG2814	Major facilitator Superfamily
I636_14790	COG0724	RNA recognition motif
I636_14805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I636_14810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I636_14830	COG0583	DNA-binding transcription factor activity
I636_14845	COG0640	Transcriptional regulator
I636_14855	COG0431	NADPH-dependent FMN reductase
I636_14860	COG0798	PFAM Bile acid sodium symporter
I636_14865	COG2201	protein-glutamate methylesterase activity
I636_14870	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I636_14880	COG0642	Histidine kinase
I636_14905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I636_14935	COG1748	Saccharopine dehydrogenase
I636_14950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I636_14955	COG3107	peptidoglycan biosynthetic process
I636_14965	COG0438	transferase activity, transferring glycosyl groups
I636_14975	COG2823	Periplasmic or secreted lipoprotein
I636_14995	COG4585	Histidine kinase
I636_15000	COG2197	response regulator
I636_15015	COG4771	TonB-dependent receptor
I636_15025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I636_15030	COG0372	Belongs to the citrate synthase family
I636_15035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I636_15040	COG2828	Protein conserved in bacteria
I636_15045	COG2199	diguanylate cyclase activity
I636_15045	COG2203	Gaf domain
I636_15050	COG1940	carbohydrate kinase activity
I636_15090	COG5002	protein histidine kinase activity
I636_15090	COG2198	Histidine kinase
I636_15090	COG0784	Response regulator, receiver
I636_15095	COG3023	N-Acetylmuramoyl-L-alanine amidase
I636_15100	COG0067	glutamate synthase
I636_15100	COG0070	glutamate synthase
I636_15100	COG0069	glutamate synthase activity
I636_15105	COG0493	'glutamate synthase
I636_15120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I636_15125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I636_15130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I636_15135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I636_15150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I636_15155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I636_15165	COG4942	peptidase
I636_15170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I636_15175	COG0738	Major facilitator superfamily
I636_15185	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I636_15215	COG1914	H( )-stimulated, divalent metal cation uptake system
I636_15220	COG0436	Aminotransferase
I636_15240	COG0174	glutamine synthetase
I636_15250	COG3852	Histidine kinase
I636_15255	COG2204	response regulator
I636_15260	COG3437	response regulator, receiver
I636_15265	COG0204	Acyl-transferase
I636_15305	COG4999	Histidine kinase
I636_15305	COG3437	response regulator, receiver
I636_15305	COG2205	protein histidine kinase activity
I636_15305	COG3850	Histidine kinase
I636_15310	COG0525	valine-tRNA ligase activity
I636_15315	COG2927	DNA polymerase III (CHI subunit)
I636_15320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I636_15325	COG0795	lipopolysaccharide-transporting ATPase activity
I636_15330	COG0795	lipopolysaccharide-transporting ATPase activity
I636_15410	COG4974	Belongs to the 'phage' integrase family
I636_15425	COG2856	Zn peptidase
I636_15540	COG3250	beta-galactosidase activity
I636_15550	COG4948	Mandelate Racemase Muconate Lactonizing
I636_15555	COG3661	Belongs to the glycosyl hydrolase 67 family
I636_15570	COG2203	Gaf domain
I636_15570	COG2199	diguanylate cyclase activity
I636_15595	COG0673	inositol 2-dehydrogenase activity
I636_15600	COG2198	Histidine kinase
I636_15600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I636_15600	COG0784	Response regulator, receiver
I636_15600	COG2205	protein histidine kinase activity
I636_15605	COG0628	permease
I636_15620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I636_15625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I636_15630	COG4558	Periplasmic binding protein
I636_15640	COG4206	TonB-dependent receptor
I636_15650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I636_15655	COG0697	spore germination
I636_15680	COG1971	Probably functions as a manganese efflux pump
I636_15690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I636_15705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I636_15720	COG0679	Auxin Efflux Carrier
I636_15750	COG1131	(ABC) transporter
I636_15760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I636_15770	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I636_15810	COG2205	protein histidine kinase activity
I636_15820	COG3901	Regulator of nitric oxide reductase transcription
I636_15820	COG0348	domain, Protein
I636_15830	COG2197	response regulator
I636_15855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I636_15870	COG4771	TonB-dependent receptor
I636_15880	COG0583	DNA-binding transcription factor activity
I636_15885	COG1304	FMN binding
I636_15890	COG0277	FAD linked oxidase domain protein
I636_15900	COG1462	curli production assembly transport component CsgG
I636_15930	COG2197	response regulator
I636_15945	COG0513	Belongs to the DEAD box helicase family
I636_15950	COG1294	oxidase, subunit
I636_15955	COG1271	oxidase subunit
I636_15965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I636_15975	COG2124	cytochrome p450
I636_15995	COG2203	Gaf domain
I636_15995	COG2199	diguanylate cyclase activity
I636_16020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I636_16050	COG2337	Toxic component of a toxin-antitoxin (TA) module
I636_16110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I636_16110	COG3264	Mechanosensitive ion channel
I636_16135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I636_16150	COG1309	transcriptional regulator
I636_16160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_16170	COG1573	uracil-dna glycosylase
I636_16175	COG3300	MHYT domain
I636_16175	COG5001	Diguanylate cyclase
I636_16195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I636_16220	COG1983	PspC domain protein
I636_16225	COG1842	Phage shock protein A
I636_16235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_16255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I636_16255	COG2885	chlorophyll binding
I636_16260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I636_16270	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I636_16275	COG0204	Acyl-transferase
I636_16280	COG0204	Acyl-transferase
I636_16285	COG0668	transmembrane transport
I636_16300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I636_16305	COG0733	neurotransmitter:sodium symporter activity
I636_16320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I636_16335	COG0716	FMN binding
I636_16345	COG0848	biopolymer transport protein
I636_16360	COG0457	Tetratricopeptide repeat
I636_16365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I636_16375	COG1215	transferase activity, transferring glycosyl groups
I636_16390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I636_16395	COG0702	epimerase
I636_16410	COG5002	protein histidine kinase activity
I636_16410	COG5001	Diguanylate cyclase
I636_16425	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I636_16435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_16445	COG0583	DNA-binding transcription factor activity
I636_16450	COG0121	glutamine amidotransferase
I636_16455	COG4682	membrane
I636_16475	COG1953	Uracil, thiamine, allantoin
I636_16480	COG4771	TonB-dependent receptor
I636_16490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I636_16495	COG0778	Nitroreductase
I636_16500	COG0596	Alpha beta hydrolase
I636_16505	COG0251	oxidation-reduction process
I636_16510	COG1335	isochorismatase
I636_16515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_16520	COG1309	transcriptional regulator
I636_16535	COG4628	conserved protein (DUF2132)
I636_16540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I636_16550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I636_16560	COG1477	protein flavinylation
I636_16565	COG2871	sodium ion transport
I636_16570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_16575	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_16580	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_16585	COG1805	sodium ion transport
I636_16590	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I636_16595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I636_16600	COG0545	Peptidyl-prolyl cis-trans isomerase
I636_16605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I636_16610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I636_16625	COG0039	L-malate dehydrogenase activity
I636_16630	COG1438	arginine binding
I636_16655	COG0572	uridine kinase
I636_16660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I636_16680	COG0745	RESPONSE REGULATOR receiver
I636_16680	COG3706	GGDEF domain
I636_16685	COG2176	DNA-directed DNA polymerase activity
I636_16690	COG1125	glycine betaine transport
I636_16690	COG0517	IMP dehydrogenase activity
I636_16695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I636_16705	COG2205	protein histidine kinase activity
I636_16715	COG0189	ligase activity
I636_16725	COG0189	ligase activity
I636_16725	COG4067	protein conserved in archaea
I636_16750	COG1283	sodium-dependent phosphate transmembrane transporter activity
I636_16755	COG0667	Aldo Keto reductase
I636_16770	COG5001	Diguanylate cyclase
I636_16785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I636_16795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I636_16800	COG0840	transmembrane signaling receptor activity
I636_16820	COG2274	protein secretion by the type I secretion system
I636_16825	COG0583	DNA-binding transcription factor activity
I636_16850	COG1216	Glycosyl transferase, family 2
I636_16850	COG0438	transferase activity, transferring glycosyl groups
I636_16890	COG0457	Tetratricopeptide repeat
I636_16920	COG1216	Glycosyl transferase, family 2
I636_16920	COG0463	Glycosyl transferase, family 2
I636_17010	COG4372	Transposase
I636_17030	COG4372	Transposase
I636_17080	COG2161	toxin-antitoxin pair type II binding
I636_17090	COG0202	RNA polymerase activity
I636_17115	COG0201	protein transport
I636_17135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I636_17170	COG0784	Response regulator, receiver
I636_17170	COG5002	protein histidine kinase activity
I636_17195	COG0557	exoribonuclease II activity
I636_17225	COG4771	TonB-dependent receptor
I636_17240	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I636_17255	COG0543	2 iron, 2 sulfur cluster binding
I636_17270	COG2234	aminopeptidase activity
I636_17280	COG4251	negative regulation of phosphorylation
I636_17290	COG1271	oxidase subunit
I636_17295	COG1294	oxidase, subunit
I636_17305	COG1522	sequence-specific DNA binding
I636_17315	COG1278	Cold shock
I636_17320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I636_17340	COG0339	signal peptide processing
I636_17345	COG2201	protein-glutamate methylesterase activity
I636_17355	COG3852	Histidine kinase
I636_17365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I636_17370	COG0243	molybdopterin cofactor binding
I636_17375	COG0823	Involved in the tonB-independent uptake of proteins
I636_17375	COG1506	peptidase
I636_17375	COG4946	Tricorn protease homolog
I636_17425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I636_17435	COG2197	response regulator
I636_17445	COG0189	ligase activity
I636_17465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I636_17470	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I636_17475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I636_17490	COG0281	malic enzyme
I636_17500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I636_17530	COG0456	acetyltransferase
I636_17540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I636_17545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I636_17550	COG2177	Part of the ABC transporter FtsEX involved in
I636_17555	COG2884	Cell division ATP-binding protein ftsE
I636_17560	COG0552	protein localization to endoplasmic reticulum
I636_17575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I636_17580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I636_17585	COG0617	tRNA 3'-terminal CCA addition
I636_17590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I636_17605	COG0076	glutamate decarboxylase activity
I636_17625	COG0842	Transport permease protein
I636_17630	COG1131	(ABC) transporter
I636_17635	COG0745	RESPONSE REGULATOR receiver
I636_17640	COG2205	protein histidine kinase activity
I636_17645	COG4774	siderophore transport
I636_17665	COG1253	flavin adenine dinucleotide binding
I636_17675	COG1966	Carbon starvation protein
I636_17695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I636_17700	COG0049	tRNA binding
I636_17705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I636_17710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I636_17715	COG0085	RNA polymerase activity
I636_17720	COG0222	ribosome binding
I636_17725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I636_17730	COG0081	regulation of translation
I636_17735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I636_17755	COG0250	Participates in transcription elongation, termination and antitermination
I636_17760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I636_17765	COG1132	(ABC) transporter
I636_17770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I636_17775	COG3590	peptidase
I636_17785	COG0513	Belongs to the DEAD box helicase family
I636_17790	COG0418	dihydroorotase activity
I636_17795	COG3040	lipid binding
I636_17800	COG4989	oxidoreductase activity
I636_17805	COG0346	lactoylglutathione lyase activity
I636_17810	COG0668	transmembrane transport
I636_17830	COG0302	gtp cyclohydrolase
I636_17840	COG2957	Belongs to the agmatine deiminase family
I636_17845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I636_17860	COG1201	RNA secondary structure unwinding
I636_17870	COG1793	dna ligase
I636_17875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I636_17880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I636_17890	COG1410	methionine synthase
I636_17890	COG0646	methionine synthase
I636_17895	COG0625	glutathione transferase activity
I636_17900	COG0625	glutathione transferase activity
I636_17910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I636_17915	COG0330	HflC and HflK could
I636_17920	COG0330	HflC and HflK could
I636_17925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I636_17930	COG1923	regulation of RNA biosynthetic process
I636_17935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I636_17950	COG0802	atpase or kinase
I636_17955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I636_17955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I636_17960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I636_17970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I636_17980	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I636_17985	COG0735	belongs to the Fur family
I636_17995	COG0432	Pfam Uncharacterised protein family UPF0047
I636_18005	COG0305	Participates in initiation and elongation during chromosome replication
I636_18030	COG2258	MOSC domain
I636_18060	COG2205	protein histidine kinase activity
I636_18080	COG0840	transmembrane signaling receptor activity
I636_18085	COG5002	protein histidine kinase activity
I636_18090	COG0840	transmembrane signaling receptor activity
I636_18125	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_18135	COG2723	6-phospho-beta-galactosidase activity
I636_18140	COG1609	Transcriptional regulator
I636_18145	COG0477	Major facilitator Superfamily
I636_18145	COG2814	Major facilitator Superfamily
I636_18150	COG4319	ketosteroid isomerase
I636_18170	COG2375	cellular response to nickel ion
I636_18175	COG3237	CsbD-like
I636_18205	COG0596	Alpha beta hydrolase
I636_18205	COG0508	dehydrogenase complex catalyzes the overall conversion of
I636_18225	COG3038	cytochrome b561
I636_18235	COG1252	NADH dehydrogenase
I636_18250	COG0583	DNA-binding transcription factor activity
I636_18255	COG2067	long-chain fatty acid transport protein
I636_18260	COG2130	NADP-dependent
I636_18265	COG5001	Diguanylate cyclase
I636_18265	COG2203	Gaf domain
I636_18265	COG4251	negative regulation of phosphorylation
I636_18265	COG3706	GGDEF domain
I636_18270	COG0784	Response regulator, receiver
I636_18270	COG2205	protein histidine kinase activity
I636_18280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I636_18285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I636_18290	COG1349	DNA-binding transcription factor activity
I636_18295	COG0673	inositol 2-dehydrogenase activity
I636_18310	COG0697	spore germination
I636_18315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I636_18320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I636_18325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I636_18330	COG1166	arginine decarboxylase activity
I636_18340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I636_18345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I636_18350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I636_18420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I636_18425	COG0109	protoheme IX farnesyltransferase activity
I636_18445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I636_18490	COG3030	protein affecting phage T7 exclusion by the F plasmid
I636_18495	COG1324	tolerance protein
I636_18500	COG4232	protein-disulfide reductase activity
I636_18505	COG0739	heme binding
I636_18510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I636_18515	COG0511	ligase activity, forming carbon-carbon bonds
I636_18520	COG0439	Biotin carboxylase
I636_18565	COG0154	amidase activity
I636_18580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I636_18585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I636_18600	COG0151	Belongs to the GarS family
I636_18615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I636_18620	COG3954	Phosphoribulokinase
I636_18630	COG0745	RESPONSE REGULATOR receiver
I636_18650	COG1501	Belongs to the glycosyl hydrolase 31 family
I636_18660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I636_18670	COG3031	protein transport across the cell outer membrane
I636_18680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I636_18685	COG1459	type II secretion system
I636_18690	COG2165	general secretion pathway protein
I636_18695	COG2165	general secretion pathway protein
I636_18700	COG2165	general secretion pathway protein
I636_18705	COG4795	General secretion pathway protein
I636_18720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I636_18735	COG1012	belongs to the aldehyde dehydrogenase family
I636_18745	COG1011	Hydrolase
I636_18750	COG0494	nUDIX hydrolase
I636_18755	COG1218	3'(2'),5'-bisphosphate nucleotidase
I636_18770	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I636_18780	COG3089	Belongs to the UPF0270 family
I636_18785	COG0429	hydrolase of the alpha beta-hydrolase fold
I636_18795	COG0488	(ABC) transporter
I636_18815	COG2900	Belongs to the SlyX family
I636_18825	COG0545	Peptidyl-prolyl cis-trans isomerase
I636_18835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I636_18840	COG2183	response to ionizing radiation
I636_18875	COG2207	Transcriptional regulator
I636_18875	COG1609	Transcriptional regulator
I636_18880	COG2211	Major facilitator Superfamily
I636_18895	COG3693	PFAM glycoside hydrolase, family 10
I636_18900	COG0667	Aldo Keto reductase
I636_18905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I636_18910	COG2115	Belongs to the xylose isomerase family
I636_18915	COG1070	Carbohydrate kinase
I636_18930	COG1472	Belongs to the glycosyl hydrolase 3 family
I636_18935	COG0477	Major facilitator Superfamily
I636_18980	COG0596	Alpha beta hydrolase
I636_18985	COG1040	competence protein
I636_19005	COG1794	racemase activity, acting on amino acids and derivatives
I636_19015	COG0534	Mate efflux family protein
I636_19030	COG1999	signal sequence binding
I636_19035	COG0109	protoheme IX farnesyltransferase activity
I636_19040	COG1612	heme a metabolic process
I636_19060	COG1845	cytochrome c oxidase, subunit III
I636_19065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I636_19070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I636_19075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I636_19095	COG0129	dihydroxy-acid dehydratase activity
I636_19105	COG0606	chelatase, subunit chli
I636_19110	COG0583	DNA-binding transcription factor activity
I636_19120	COG2814	Major facilitator Superfamily
I636_19130	COG0729	surface antigen
I636_19135	COG2911	Protein conserved in bacteria
I636_19160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I636_19170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I636_19190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I636_19215	COG1228	amidohydrolase
I636_19240	COG0425	Belongs to the sulfur carrier protein TusA family
I636_19260	COG1561	YicC-like family, N-terminal region
I636_19270	COG3550	peptidyl-serine autophosphorylation
I636_19275	COG3620	sequence-specific DNA binding
I636_19365	COG3119	arylsulfatase activity
I636_19370	COG0714	Associated with various cellular activities
I636_19385	COG2304	oxidoreductase activity
I636_19420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I636_19430	COG1960	acyl-CoA dehydrogenase activity
I636_19440	COG1024	Enoyl-CoA hydratase
I636_19475	COG3177	Filamentation induced by cAMP protein fic
I636_19485	COG1609	Transcriptional regulator
I636_19500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I636_19500	COG2199	diguanylate cyclase activity
I636_19525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I636_19545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I636_19550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I636_19570	COG1475	DNA binding
I636_19575	COG1192	Involved in chromosome partitioning
I636_19600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I636_19605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I636_19615	COG0706	membrane insertase activity
I636_19620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I636_19625	COG0594	ribonuclease P activity
I636_19630	COG0230	Belongs to the bacterial ribosomal protein bL34 family