locus-tag class description I635_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) I635_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) I635_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) I635_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I635_00030 ENOG4105C38 Glycyl-tRNA synthetase beta subunit I635_00035 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit I635_00040 ENOG4108R3E Dna-3-methyladenine glycosylase i I635_00050 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) I635_00060 ENOG4106RE7 Cytochrome I635_00065 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) I635_00070 ENOG4105C2M dna polymerase I I635_00075 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain I635_00080 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) I635_00085 ENOG4105C1A potassium transporter peripheral membrane I635_00090 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B I635_00095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) I635_00100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) I635_00110 ENOG4105C79 DNA protecting protein DprA I635_00115 ENOG4108RPN Protein smg homolog I635_00125 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I635_00130 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) I635_00135 ENOG4105EIF outer membrane protein W I635_00145 ENOG4105E2X shikimate dehydrogenase I635_00150 ENOG4108Z0R Transferase I635_00180 ENOG4105C0B DNA polymerase III (alpha subunit) I635_00210 ENOG4105IIU Aminopeptidase I635_00215 ENOG4106WTF Glycosyl transferase, family 2 I635_00220 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) I635_00225 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase I635_00230 ENOG4105W5Q DNA repair protein (RadC I635_00250 ENOG4105E3R (LipO)protein I635_00255 ENOG4105KDC 50s ribosomal protein l28 I635_00260 ENOG4105W0E 50S ribosomal protein L33 I635_00270 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) I635_00275 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) I635_00280 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) I635_00285 ENOG4105DKP glycosyl transferase, family 9 I635_00300 ENOG4105BZU Histidine kinase I635_00305 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I635_00310 ENOG4105CPQ Dehydrogenase I635_00315 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) I635_00330 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) I635_00335 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) I635_00350 ENOG4105W0Z cytoplasmic protein I635_00355 ENOG4105C4R Atp-dependent dna helicase I635_00360 ENOG4105BZU Histidine kinase I635_00365 ENOG4105MPD Cytochrome I635_00385 ENOG4105DFD Na H antiporter I635_00405 ENOG4108VCT Sulfite exporter TauE/SafE I635_00420 ENOG4105D05 Receptor I635_00435 ENOG4108JJ8 (ABC) transporter I635_00440 ENOG4108JJ9 ABC, transporter I635_00450 ENOG4105C4M (Ubiquinol oxidase) subunit I I635_00460 ENOG4105VFE sira family I635_00470 ENOG4105D3R alkyl hydroperoxide reductase I635_00480 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I635_00510 ENOG4105C94 Transporter I635_00555 ENOG4105DVF Cytosine-specific methyltransferase I635_00560 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) I635_00570 ENOG4105D0S secretion protein (HlyD I635_00575 ENOG4105CJ1 ABC, transporter I635_00580 ENOG4105CMI transporter I635_00595 ENOG4105C1G acyl-Coa dehydrogenase I635_00600 ENOG4105DQS Transcriptional regulator I635_00610 ENOG4105CM6 amino acid regulated cytosolic protein I635_00630 ENOG4105MZU cell filamentation protein I635_00635 ENOG4105D41 biosynthesis protein thiH I635_00640 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) I635_00650 ENOG4105D06 uba thif-type nad fad binding protein I635_00655 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) I635_00660 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) I635_00665 ENOG410601J HemY protein I635_00670 ENOG4105ECF c-methyltransferase I635_00675 ENOG41076E6 Uroporphyrinogen-III Synthase I635_00680 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) I635_00700 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) I635_00705 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) I635_00710 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) I635_00715 ENOG4105KME endoribonuclease L-psp I635_00720 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase I635_00725 ENOG4105CB5 ATP-dependent DNA helicase recG I635_00730 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) I635_00755 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component I635_00760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) I635_00770 ENOG4105CBX hi0933 family I635_00825 ENOG4105W1Y Transcriptional regulator I635_00850 ENOG4105BZU Histidine kinase I635_00855 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) I635_00865 ENOG4105KPY Small multidrug resistance protein I635_00880 ENOG4105C1P efflux transporter, rnd family, mfp subunit I635_00885 ENOG4105BZS acriflavin resistance protein I635_00895 ENOG4105CYC Transferase I635_00915 ENOG4108N3W hemolysin secretion protein I635_00925 ENOG4108NST exported protein I635_00930 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) I635_00935 ENOG4105BZU Histidine kinase I635_00950 ENOG4105C9U ATP-dependent DNA helicase RecQ I635_00955 ENOG4105CJW magnesium transporter I635_00960 ENOG4105FR1 rard protein I635_00965 ENOG4105BZU Histidine kinase I635_00970 ENOG4105C4R Atp-dependent dna helicase I635_00975 ENOG4105D7W serine acetyltransferase I635_00980 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant I635_00985 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I635_00995 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) I635_01000 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) I635_01020 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) I635_01030 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase I635_01035 ENOG4105DFU Cell wall formation (By similarity) I635_01040 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 I635_01045 ENOG4105F0N pyrophosphate phospho-hydrolase I635_01075 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) I635_01080 ENOG4107RDB Major Facilitator I635_01085 ENOG4107VXZ Hydrolase I635_01115 ENOG4105F0Z galactose-1-phosphate uridylyltransferase I635_01120 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) I635_01130 ENOG4107XMK single-stranded DNA-binding protein I635_01145 ENOG4105CMR udp-glucose 4-epimerase I635_01150 ENOG4105CNT hydrolase family 2 I635_01170 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) I635_01175 ENOG4105E98 transcriptional regulator DeoR family I635_01180 ENOG4105C6V Glycerol-3-phosphate dehydrogenase I635_01230 ENOG4107QHF type ii secretion system protein e I635_01235 ENOG4105D7Q type ii secretion system I635_01280 ENOG4105DFF Rod shape-determining protein mreb I635_01285 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) I635_01290 ENOG4105VQ7 Rod shape-determining protein MreD I635_01295 ENOG4108Z03 MAF-like protein I635_01300 ENOG4105C03 ribonuclease I635_01315 ENOG4105D1U peptidase U62 modulator of DNA gyrase I635_01320 ENOG4105N42 UPF0307 protein I635_01325 ENOG4105CMS peptidase U62, modulator of DNA gyrase I635_01330 ENOG4105CNT hydrolase family 2 I635_01335 ENOG41065U4 response regulator I635_01340 ENOG4105BZU Histidine kinase I635_01345 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) I635_01350 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) I635_01355 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) I635_01360 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) I635_01365 ENOG4105CEN a g-specific adenine glycosylase I635_01370 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) I635_01390 ENOG4105GR3 Histidine kinase I635_01395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I635_01420 ENOG4108IJF Heavy metal efflux pump, CzcA I635_01500 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) I635_01515 ENOG4107JPU I635_01520 ENOG4108USZ hydrogenase I635_01530 ENOG4105E3S small subunit I635_01550 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) I635_01555 ENOG4107RSS Hydrogenase accessory protein HypB I635_01560 ENOG4105CQS hydrogenase expression formation protein HypD I635_01570 ENOG4105C45 hydrogenase expression formation protein (HypE) I635_01580 ENOG4105C59 p-type ATPase I635_01660 ENOG4105PGM cation diffusion facilitator family transporter I635_01670 ENOG41080IJ Diacylglycerol kinase I635_01675 ENOG4105DIJ Phosphoethanolamine transferase I635_01680 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) I635_01690 ENOG4105CKK Glycosyl transferase, family 2 I635_01700 ENOG4105GR3 Histidine kinase I635_01740 ENOG4105C59 p-type ATPase I635_01780 ENOG4107R7I amino acid I635_01790 ENOG4105E3B Multicopper oxidase I635_01850 ENOG4105DQ6 Transposase I635_01905 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) I635_01935 ENOG4105ETE Transcriptional regulator (LacI family I635_01950 ENOG4105EAA nucleoside I635_01975 ENOG4105C0A alcohol dehydrogenase I635_01980 ENOG4105CM2 brancheD-chain amino acid aminotransferase I635_01985 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) I635_01995 ENOG4107QM5 aconitate hydratase I635_02005 ENOG4107QHF type ii secretion system protein e I635_02015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) I635_02020 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) I635_02025 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) I635_02030 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity I635_02035 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) I635_02040 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) I635_02045 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) I635_02050 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) I635_02055 ENOG41083MP 50s ribosomal protein l29 I635_02060 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal I635_02065 ENOG4107RJ7 Glycosyl transferase (Group 1 I635_02075 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase I635_02095 ENOG4105C8Q Methyl-accepting chemotaxis I635_02100 ENOG4105DGW oligopeptidase A I635_02120 ENOG4105CQ7 ATP-dependent helicase I635_02125 ENOG4105CVE Lytic murein transglycosylase I635_02130 ENOG4105BZ4 penicillin-binding protein I635_02145 ENOG4105CKW Inner membrane protein yedI I635_02150 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF I635_02160 ENOG4108YZA Nitrogen regulatory protein pii I635_02170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I635_02175 ENOG4105EZR dyp-type peroxidase family protein I635_02185 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase I635_02190 ENOG4105CXT aspartate transcarbamylase I635_02215 ENOG4105BZU Histidine kinase I635_02220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I635_02230 ENOG4105BZU Histidine kinase I635_02240 ENOG4105C26 Dehydrogenase I635_02250 ENOG4105C8Y Acetylornithine aminotransferase I635_02265 ENOG4105C31 Tryptophanyl-tRNA synthetase I635_02270 ENOG4105DJV ribulose-phosphate 3-epimerase I635_02290 ENOG4105DFE Dna adenine methylase I635_02300 ENOG4105D49 3-dehydroquinate synthase I635_02305 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) I635_02310 ENOG4105E4G Type IV pilus I635_02335 ENOG4108JQC penicillin-binding protein 1A I635_02340 ENOG4107R1I NAD-dependent malic enzyme I635_02355 ENOG4105CYM Glutathione S-transferase I635_02365 ENOG4105CH6 catalase I635_02380 ENOG4105BZU Histidine kinase I635_02385 ENOG4107QZM n-acetylglutamate synthase I635_02390 ENOG4105CH7 arginosuccinase I635_02395 ENOG4105CDH Citrulline--aspartate ligase I635_02405 ENOG4105CAS nag kinase I635_02410 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase I635_02415 ENOG4108Z5K methylglyoxal synthase I635_02425 ENOG4105E3W Two component transcriptional regulator (Winged helix family I635_02430 ENOG4105E0F Histidine kinase I635_02435 ENOG4108EUD Lysophospholipase I635_02440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) I635_02450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase I635_02455 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) I635_02460 ENOG4105VW4 glutaredoxin 3 I635_02465 ENOG4107YZP Rhodanese domain protein I635_02470 ENOG41063SB peptidase I635_02475 ENOG4105PXI polysaccharide deacetylase I635_02495 ENOG4105DJ4 phosphatidylserine decarboxylase I635_02500 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) I635_02505 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) I635_02530 ENOG4105C7K acetolactate synthase I635_02535 ENOG4108ZP8 Acetolactate synthase small subunit I635_02545 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) I635_02550 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) I635_02555 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) I635_02565 ENOG4105F8V Hydrolase, tatD family I635_02575 ENOG4105D52 delta-aminolevulinic acid dehydratase I635_02580 ENOG4105C9X ppx gppa phosphatase I635_02585 ENOG4105C1J atp-dependent rna helicase I635_02590 ENOG4105K63 Thioredoxin I635_02600 ENOG4105CH2 amidohydrolase I635_02605 ENOG4105BZU Histidine kinase I635_02610 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) I635_02615 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) I635_02620 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit I635_02640 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I635_02650 ENOG4107QR8 Thioredoxin I635_02670 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis I635_02675 ENOG4105C26 Dehydrogenase I635_02690 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I635_02695 ENOG4107S6Z Na H antiporter I635_02710 ENOG4105EHZ conserved protein UCP016719 I635_02715 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate I635_02720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) I635_02735 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase I635_02750 ENOG4105K3M )-transporter I635_02760 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA I635_02765 ENOG4105I4A GCN5-related N-acetyltransferase I635_02795 ENOG41084S7 Plasmid maintenance system antidote protein I635_02810 ENOG4105K4U addiction module toxin, RelE StbE family I635_02900 ENOG4105CHU acetyl-coa acetyltransferase I635_02905 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I635_02910 ENOG4107SC1 transglycosylase I635_02915 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) I635_02925 ENOG4105EAH synthase I635_02930 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) I635_02935 ENOG4105K46 50S ribosomal protein l27 I635_02940 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control I635_02955 ENOG4108K5P (LipO)protein I635_02960 ENOG4108UM1 dedA family I635_02965 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) I635_02970 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) I635_02975 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) I635_02980 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) I635_02985 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) I635_02995 ENOG4105C8Q Methyl-accepting chemotaxis I635_03035 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) I635_03040 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase I635_03045 ENOG4105HF0 Membrane I635_03050 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) I635_03055 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) I635_03065 ENOG4105BZU Histidine kinase I635_03085 ENOG4105D3G Pseudouridine synthase I635_03090 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) I635_03105 ENOG4108IAB Phoh family I635_03115 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I635_03120 ENOG4105C1J atp-dependent rna helicase I635_03140 ENOG4105DFG type I secretion outer membrane protein I635_03145 ENOG41087AY ADP-Ribose pyrophosphatase I635_03155 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) I635_03160 ENOG4105IPS esterase I635_03165 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I635_03175 ENOG4107VXZ Hydrolase I635_03200 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein I635_03205 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) I635_03210 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) I635_03215 ENOG4105UGU tonB-dependent Receptor I635_03225 ENOG41068WN I635_03230 ENOG4105CNM Receptor I635_03240 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I635_03245 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) I635_03255 ENOG4105M85 Bola protein I635_03285 ENOG4105CHH sulfate transporter I635_03290 ENOG4107QZF nitrite reductase NADPH large subunit I635_03305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I635_03310 ENOG4108I0Q anthranilate phosphoribosyltransferase I635_03315 ENOG4107SDU Methyl-accepting chemotaxis I635_03330 ENOG4105D7T ABC transporter I635_03345 ENOG4108Z33 Thiol disulfide Interchange Protein I635_03350 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I635_03355 ENOG4105E27 serine threonine protein kinase I635_03360 ENOG4105C58 cytochrome c oxidase accessory protein ccog I635_03375 ENOG4105CSU acyl-Coa dehydrogenase I635_03380 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr I635_03390 ENOG4105CXK mandelate racemase muconate lactonizing I635_03395 ENOG4105MP9 class II Aldolase I635_03405 ENOG410624X efflux transporter, rnd family, mfp subunit I635_03410 ENOG4105BZS acriflavin resistance protein I635_03425 ENOG4105C8Q Methyl-accepting chemotaxis I635_03430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I635_03435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) I635_03450 ENOG4105VCC 30S ribosomal protein S21 I635_03455 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I635_03465 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) I635_03470 ENOG4107ZVW dihydroneopterin aldolase I635_03480 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) I635_03485 ENOG4105K59 histidine triad (HIT) protein I635_03500 ENOG4105DKK Benzoate I635_03505 ENOG4108JCI Transcriptional regulator I635_03510 ENOG4105DH7 May be involved in recombination (By similarity) I635_03515 ENOG4105BZU Histidine kinase I635_03520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I635_03525 ENOG4105BZU Histidine kinase I635_03560 ENOG4109015 Biopolymer transport protein exbD tolR I635_03565 ENOG41067XB TonB family I635_03575 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_03580 ENOG4105BZU Histidine kinase I635_03585 ENOG4105CEY Amp-dependent synthetase and ligase I635_03600 ENOG4107QIJ Aconitate hydratase 2 I635_03605 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I635_03620 ENOG4107QIJ Aconitate hydratase 2 I635_03630 ENOG4105CFH Aspartokinase I635_03635 ENOG4105C8Q Methyl-accepting chemotaxis I635_03640 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) I635_03645 ENOG4105NWN ApaG protein I635_03650 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) I635_03655 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) I635_03660 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) I635_03665 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) I635_03670 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) I635_03675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I635_03680 ENOG4105T95 Thiol disulfide interChange protein I635_03685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) I635_03695 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) I635_03700 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) I635_03705 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) I635_03710 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) I635_03715 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) I635_03720 ENOG4105DXN mazG family I635_03755 ENOG4105CEY Amp-dependent synthetase and ligase I635_03765 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) I635_03775 ENOG4105CKK Glycosyl transferase, family 2 I635_03795 ENOG4105DHQ Histidine kinase I635_03810 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) I635_03815 ENOG4108UJD 30S ribosomal protein S9 I635_03820 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) I635_03825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) I635_03830 ENOG4105EIX cytochrome c1 I635_03835 ENOG4107MKT Stringent starvation protein a I635_03840 ENOG4105KB2 stringent starvation protein b I635_03845 ENOG4105CJW magnesium transporter I635_03850 ENOG41080Z8 PHOSPHOCARRIER protein I635_03855 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) I635_03860 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN I635_03865 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA I635_03870 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I635_03875 ENOG4108IUZ ABC transporter I635_03880 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA I635_03890 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase I635_03895 ENOG4105C2X Arabinose 5-phosphate isomerase I635_03905 ENOG4105DHJ ABC, transporter I635_03910 ENOG4105CY3 ABC transporter, permease I635_03915 ENOG4107PE3 Mammalian cell entry related domain protein I635_03920 ENOG4105E3I toluene tolerance I635_03930 ENOG4105VFK BolA family I635_03935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) I635_03940 ENOG4105C0H protease I635_03945 ENOG4105C0H protease I635_03955 ENOG4105D6Z AFG1 family ATPase I635_03960 ENOG4105CDY transcriptional regulatory protein I635_03990 ENOG4105D05 Receptor I635_03995 ENOG4108RNG Permease of the drug metabolite transporter I635_04005 ENOG4105BZU Histidine kinase I635_04025 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP I635_04030 ENOG4105CV1 Transketolase (EC 2.2.1.1) I635_04035 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I635_04040 ENOG4105BZA Phosphoglycerate kinase I635_04045 ENOG4105WYW fructose-bisphosphate aldolase I635_04055 ENOG4105C1P efflux transporter, rnd family, mfp subunit I635_04065 ENOG4105ENJ RND efflux system, outer membrane lipoprotein I635_04070 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I635_04075 ENOG4105C9X ppx gppa phosphatase I635_04090 ENOG4105C8U phosphate abc transporter I635_04100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) I635_04110 ENOG4105CJ3 phosphate transporter I635_04120 ENOG4105C5Q Transcriptional regulator I635_04130 ENOG4108UT2 hemolysin iii I635_04135 ENOG4105K56 Transcriptional regulator I635_04140 ENOG4108ZHJ Organic hydroperoxide resistance protein I635_04155 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein I635_04165 ENOG4107SDU Methyl-accepting chemotaxis I635_04175 ENOG4107RH8 nuclease SbcCD subunit D I635_04180 ENOG4105EYH Exonuclease I635_04195 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) I635_04205 ENOG4105CI2 imidazolone-5-propionate hydrolase I635_04210 ENOG4105CZE histidine utilization repressor I635_04215 ENOG4105CGP Urocanate hydratase I635_04220 ENOG4105C84 Histidine ammonia-lyase I635_04250 ENOG4105C5H ABC transporter I635_04275 ENOG4105D64 Mechanosensitive ion channel I635_04325 ENOG4108KU3 Integrase I635_04330 ENOG4105E5H Transposase I635_04380 ENOG4105F5W AtP-binding protein I635_04400 ENOG4105CVR type I restriction-modification system I635_04415 ENOG4105DZR Type I site-specific deoxyribonuclease I635_04460 ENOG41067MG lrgb family I635_04490 ENOG4105CSA Coproporphyrinogen iii oxidase I635_04500 ENOG4105C1J atp-dependent rna helicase I635_04505 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate I635_04520 ENOG4105CPI Metal Dependent Phosphohydrolase I635_04525 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I635_04530 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I635_04535 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I635_04540 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) I635_04550 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) I635_04555 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) I635_04560 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) I635_04570 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) I635_04575 ENOG4108IUW ABC transporter I635_04580 ENOG4108SDH ABC, transporter I635_04595 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) I635_04600 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) I635_04605 ENOG41060IM Heme exporter protein I635_04610 ENOG4105X3C heme exporter protein I635_04615 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) I635_04620 ENOG4105DA4 cytochrome c-type biogenesis protein I635_04625 ENOG4107QX9 Thiol disulfide interChange protein I635_04630 ENOG4108M1T Cytochrome c-type biogenesis protein I635_04640 ENOG410903C (LipO)protein I635_04645 ENOG4105CMR udp-glucose 4-epimerase I635_04655 ENOG4105DUX Transporter I635_04685 ENOG4105ESV Glycosyl transferase, family 4 I635_04700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase I635_04705 ENOG4105KQC Competence protein I635_04710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I635_04725 ENOG4105EWT decarboxylase family I635_04730 ENOG4105BZU Histidine kinase I635_04735 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) I635_04740 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) I635_04775 ENOG4105DR9 pseudouridine synthase I635_04780 ENOG4105QDK Flavodoxin I635_04785 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) I635_04790 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) I635_04795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) I635_04800 ENOG4105CE9 30S ribosomal protein S2 I635_04805 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) I635_04810 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) I635_04815 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) I635_04820 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) I635_04825 ENOG4105KNE Phosphatidate cytidylyltransferase I635_04830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) I635_04840 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane I635_04845 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) I635_04850 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) I635_04855 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I635_04860 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I635_04865 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I635_04870 ENOG4105C0B DNA polymerase III (alpha subunit) I635_04875 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) I635_04880 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) I635_04885 ENOG4105BZU Histidine kinase I635_04900 ENOG4108Z6B deaminase I635_04910 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) I635_04915 ENOG4108ETH Formylglycinamide ribotide synthetase I635_04925 ENOG4108DG9 Smr protein MutS2 I635_04970 ENOG4105WH1 Two component transcriptional regulator luxr family I635_05010 ENOG4107R88 Chemotaxis protein (CheV) I635_05015 ENOG4105BZU Histidine kinase I635_05020 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) I635_05025 ENOG4108ZC9 flagellar basal-body rod protein flgc I635_05030 ENOG4105W00 Flagellar hook capping protein I635_05035 ENOG4105BZE flagellar hook protein, FlgE I635_05040 ENOG4108KPB Flagellar basal-body rod protein FlgF I635_05045 ENOG4105CGA flagellar basal-body rod protein FlgG I635_05050 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) I635_05055 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) I635_05060 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj I635_05065 ENOG4105E1Q flagellar hook-associated protein I635_05080 ENOG4105I03 Flagellin I635_05085 ENOG4105I03 Flagellin I635_05090 ENOG4105I03 Flagellin I635_05095 ENOG4105I03 Flagellin I635_05100 ENOG41063QE flagellar protein FlaG I635_05110 ENOG4105MQ3 flagellar protein FliS I635_05125 ENOG4105C5E polysaccharide biosynthesis protein I635_05130 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase I635_05140 ENOG4105D2T synthase I635_05155 ENOG4105CHR reductase I635_05160 ENOG4105CEY Amp-dependent synthetase and ligase I635_05195 ENOG4106BQ7 Glycosyl Transferase I635_05205 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) I635_05210 ENOG4107S6X Glycosyl transferase, family 2 I635_05220 ENOG4108RYC glycosyltransferase I635_05235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_05240 ENOG4105BZU Histidine kinase I635_05245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_05250 ENOG4105VQ0 flagellar hook-basal body complex protein fliE I635_05255 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) I635_05260 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I635_05270 ENOG4108JIR Flagellum-specific ATP synthase I635_05290 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I635_05295 ENOG4105DD5 Flagellar motor switch protein I635_05300 ENOG4105VTB flagellar biosynthesis protein fliO I635_05305 ENOG4105CN7 Flagellar biosynthetic protein FliP I635_05310 ENOG4105VS8 Flagellar biosynthetic protein fliq I635_05315 ENOG4105D19 Role in flagellar biosynthesis (By similarity) I635_05320 ENOG4105D00 flagellar biosynthetic protein flhB I635_05325 ENOG4105D7B Flagellar biosynthesis protein flha I635_05330 ENOG4105FZW flagellar biosynthesis regulator FlhF I635_05340 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I635_05345 ENOG4108VYJ response regulator receiver protein I635_05350 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) I635_05355 ENOG4105CBS Chea signal transduction histidine kinase I635_05365 ENOG4107QJE Chromosome Partitioning Protein I635_05375 ENOG4105YFD chemotaxis, protein I635_05385 ENOG4105CVG Homoserine O-transsuccinylase I635_05390 ENOG4105C3R Methionine synthase I635_05395 ENOG4105C3R Methionine synthase I635_05405 ENOG4105NBK UPF0345 protein I635_05410 ENOG4105DZ2 Transcriptional regulator I635_05415 ENOG4105C5Q Transcriptional regulator I635_05420 ENOG4107B2H carbonic anhydrase I635_05425 ENOG4105CHH sulfate transporter I635_05440 ENOG4105C9K Endothelin-converting enzyme 1 I635_05450 ENOG4108004 Modulates RecA activity (By similarity) I635_05455 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) I635_05460 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) I635_05470 ENOG4107QSA Oxaloacetate decarboxylase I635_05475 ENOG4105D9Q decarboxylase (Beta subunit) I635_05480 ENOG4108JQ2 peptide transport system atp-binding protein I635_05485 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein I635_05490 ENOG4108EU3 peptide transport system, permease I635_05495 ENOG4108I5W peptide transport system, permease protein I635_05500 ENOG4105DEF Extracellular solute-binding protein, family 5 I635_05505 ENOG4105E51 psp operon transcriptional activator I635_05510 ENOG41087YS Phage shock protein A I635_05525 ENOG4105MIR Phenylalanine 4-monooxygenase I635_05540 ENOG4108RXX maleylacetoacetate isomerase I635_05545 ENOG4108XM1 transcriptional regulator AsnC family I635_05565 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) I635_05625 ENOG4109015 Biopolymer transport protein exbD tolR I635_05630 ENOG410822N TonB family I635_05640 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) I635_05675 ENOG4105KEG ribosomal-protein-alanine acetyltransferase I635_05690 ENOG4105HEI LysR family (Transcriptional regulator I635_05695 ENOG4105F27 Major Facilitator I635_05700 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) I635_05705 ENOG4105CV8 reductase I635_05725 ENOG4107MII Sugar-specific transcriptional regulator TrmB I635_05775 ENOG4105D64 Mechanosensitive ion channel I635_05785 ENOG4105KT5 UmuD protein I635_05805 ENOG4105CVR type I restriction-modification system I635_05955 ENOG4105KTU Transcriptional regulator, arsr family I635_05960 ENOG4107QN2 dihydrolipoyl dehydrogenase I635_05965 ENOG4107QN2 dihydrolipoyl dehydrogenase I635_05965 ENOG4107QN2 dihydrolipoyl dehydrogenase I635_05970 ENOG4105PGM cation diffusion facilitator family transporter I635_06000 ENOG4105ENJ RND efflux system, outer membrane lipoprotein I635_06040 ENOG4105T95 Thiol disulfide interChange protein I635_06075 ENOG4107QKA exodeoxyribonuclease V beta I635_06110 ENOG4108UUM single-stranded DNA-binding protein I635_06130 ENOG4105GMT ATPase associated with various cellular activities aaa_5 I635_06155 ENOG4108YGG dna repair protein I635_06175 ENOG41064T2 transcriptional regulator, lysR family I635_06240 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) I635_06245 ENOG4105C75 arginyL-tRNA synthetase I635_06275 ENOG4105BZU Histidine kinase I635_06280 ENOG4108KBJ Inner membrane protein YkgB I635_06300 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) I635_06310 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) I635_06315 ENOG4105CRK lysyL-tRNA synthetase I635_06320 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) I635_06325 ENOG4108W1A pseudouridine synthase I635_06340 ENOG4105D9M gamma-glutamylcysteine synthetase I635_06365 ENOG4108DG9 Smr protein MutS2 I635_06370 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) I635_06375 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase I635_06385 ENOG4105ED1 spovr family I635_06390 ENOG4106AKX UPF0229 protein I635_06395 ENOG4105CYN Serine protein kinase I635_06400 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I635_06405 ENOG4105M2J Glutaredoxin I635_06410 ENOG4105D05 Receptor I635_06425 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I635_06435 ENOG4105D3R alkyl hydroperoxide reductase I635_06440 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) I635_06445 ENOG4105EIY sodium-type flagellar protein motY I635_06450 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase I635_06455 ENOG4108UYE Lactoylglutathione lyase I635_06460 ENOG4105VEQ Cold shock protein I635_06480 ENOG4105DZB Electron transport complex I635_06485 ENOG4108UQQ Electron transport complex I635_06490 ENOG4105D6A Electron transport complex I635_06500 ENOG4108R3D Electron transport complex I635_06505 ENOG4105DGN Electron transport complex I635_06510 ENOG4107QJQ Mate efflux family protein I635_06515 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) I635_06525 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) I635_06530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) I635_06540 ENOG4105CAQ asparagine synthetase I635_06570 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) I635_06575 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase I635_06580 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) I635_06585 ENOG4105C11 sulfate adenylyltransferase), subunit 2 I635_06590 ENOG4105CK7 Sodium proline symporter I635_06595 ENOG4105BZU Histidine kinase I635_06640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I635_06645 ENOG4105CHU acetyl-coa acetyltransferase I635_06650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I635_06665 ENOG4105BZU Histidine kinase I635_06675 ENOG4108BY2 phosphohistidine phosphatase I635_06685 ENOG4108JU6 CBS domain protein I635_06690 ENOG4106KVJ cytochrome C assembly protein I635_06695 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY I635_06740 ENOG4105ENT Efflux transporter rnd family, mfp subunit I635_06745 ENOG4105BZ1 (ABC) transporter I635_06760 ENOG4105K5M 30s ribosomal protein S16 I635_06765 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) I635_06770 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) I635_06775 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) I635_06780 ENOG4105EN6 Membrane I635_06785 ENOG4105E39 Enoyl-CoA hydratase I635_06790 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) I635_06810 ENOG4108ZJT translation initiation factor, Sui1 I635_06820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I635_06830 ENOG4105BZU Histidine kinase I635_06840 ENOG4107WP9 Histidine kinase I635_06850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_06855 ENOG4105I03 Flagellin I635_06875 ENOG4105C9M aspartyl-trna synthetase I635_06880 ENOG4108TIT dATP pyrophosphohydrolase I635_06885 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) I635_06890 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) I635_06895 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) I635_06900 ENOG4107YD3 Thioesterase I635_06905 ENOG4105E02 MotA TolQ exbB proton channel I635_06910 ENOG4105M8F Biopolymer transport protein exbD tolR I635_06920 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) I635_06925 ENOG4105KCK Peptidoglycan-associated lipoprotein I635_06930 ENOG4105UFD tol-pal system protein YbgF I635_06940 ENOG4105EKQ RNA-directed DNA polymerase I635_06950 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) I635_06980 ENOG4108NRW Phospholipase, patatin family I635_06985 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) I635_07015 ENOG4105DS1 cytochrome b561 I635_07020 ENOG4105BZU Histidine kinase I635_07035 ENOG4105EJC lysr family transcriptional regulator I635_07040 ENOG4108VKG metal-dependent hydrolase I635_07050 ENOG4105BZS acriflavin resistance protein I635_07060 ENOG4108XG4 DNA-binding transcriptional regulator I635_07065 ENOG4108ESX Receptor I635_07085 ENOG4105BZU Histidine kinase I635_07095 ENOG4105DY2 Paraquat-inducible protein b I635_07100 ENOG4105F1S paraquat-inducible protein a I635_07115 ENOG4105C5S asparaginyl-tRNA synthetase I635_07130 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I635_07150 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) I635_07155 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) I635_07160 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I635_07165 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I635_07170 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) I635_07175 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) I635_07180 ENOG4105KJF protein tyrosine phosphatase I635_07185 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) I635_07190 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) I635_07195 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase I635_07210 ENOG4108JJ7 ABC transporter I635_07215 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) I635_07225 ENOG4105XJC Two component transcriptional regulator (Winged helix family I635_07230 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) I635_07250 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) I635_07265 ENOG4108UJV acyl-CoA thioesterase i I635_07270 ENOG4108I0Y (ABC) transporter I635_07275 ENOG4105CV6 ABC transporter, permease I635_07280 ENOG4105ECP epimerase I635_07285 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase I635_07290 ENOG4105DSF transport protein I635_07300 ENOG4105XJC Two component transcriptional regulator (Winged helix family I635_07315 ENOG4105K9H YciI-like protein I635_07320 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) I635_07325 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) I635_07330 ENOG4105DK0 Indole-3-glycerol phosphate synthase I635_07335 ENOG4108I0Q anthranilate phosphoribosyltransferase I635_07345 ENOG4105CRQ synthase (Component I) I635_07350 ENOG4105DB7 PHP domain protein I635_07355 ENOG4107RTD sua5 ycio yrdc ywlc family protein I635_07360 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) I635_07365 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) I635_07370 ENOG4105FE9 pseudouridine synthase I635_07375 ENOG4105CV8 reductase I635_07380 ENOG4108UW5 maltose o-acetyltransferase I635_07390 ENOG4106BRA Membrane I635_07405 ENOG4108JJ6 Type I secretion system ATPase I635_07415 ENOG4105FQ6 thiopurine methyltransferase I635_07420 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I635_07425 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) I635_07430 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction I635_07435 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) I635_07440 ENOG4105C0A alcohol dehydrogenase I635_07445 ENOG4105DTD Dehydrogenase I635_07455 ENOG4105DWV Homoserine O-trans-acetylase I635_07460 ENOG4105CY2 Citrate transporter I635_07475 ENOG4105BZU Histidine kinase I635_07480 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ I635_07485 ENOG4105CFG Acts as a chaperone (By similarity) I635_07490 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) I635_07495 ENOG41085AF Cytochrome I635_07500 ENOG4108M8H domain protein I635_07505 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) I635_07515 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) I635_07520 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain I635_07525 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain I635_07530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) I635_07550 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) I635_07555 ENOG4105C6K Malic enzyme I635_07570 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) I635_07575 ENOG4108JU5 Magnesium and cobalt efflux protein I635_07580 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) I635_07585 ENOG4105C9A Phoh family I635_07590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) I635_07595 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family I635_07635 ENOG4107RNH Outer membrane receptor FepA I635_07640 ENOG4108S4H thioesterase Superfamily protein I635_07645 ENOG4107XWI flavin reductase domain protein, FMN-binding I635_07665 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I635_07670 ENOG4105C3G gtp-binding protein I635_07675 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) I635_07685 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) I635_07690 ENOG4105DQ4 alcohol dehydrogenase I635_07705 ENOG4105C5T Phosphoribosyl pyrophosphate synthase I635_07710 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) I635_07715 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) I635_07720 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) I635_07725 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) I635_07730 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) I635_07735 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_07740 ENOG4108YY7 Invasion gene expression up-regulator SirB I635_07745 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase I635_07755 ENOG4105ETT transcriptional Regulator, LysR family I635_07765 ENOG4105M08 Membrane I635_07770 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) I635_07775 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) I635_07780 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) I635_07785 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) I635_07790 ENOG4107TPY serine threonine protein kinase I635_07795 ENOG4105TMB Formate nitrite transporter I635_07800 ENOG4105F8C transglutaminase domain-containing protein I635_07810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I635_07815 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) I635_07820 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 I635_07825 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) I635_07830 ENOG4105BZU Histidine kinase I635_07835 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) I635_07845 ENOG4105K8R UPF0145 protein I635_07865 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) I635_07870 ENOG4105KUZ arsenate reductase I635_07875 ENOG4107RBJ symporter I635_07895 ENOG4105F1J Homogentisate 1,2-dioxygenase I635_07915 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) I635_07925 ENOG4105BZU Histidine kinase I635_07930 ENOG4105BZU Histidine kinase I635_07950 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein I635_07975 ENOG4105BZU Histidine kinase I635_07985 ENOG4107QUY Guanine deaminase I635_08005 ENOG4105C7W Xanthine dehydrogenase I635_08020 ENOG4108R86 Transcriptional regulator I635_08035 ENOG4105C7N Xanthine uracil vitamin C permease I635_08040 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) I635_08050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_08065 ENOG4105BZU Histidine kinase I635_08080 ENOG4105C2W permease I635_08095 ENOG4105C5R Aminotransferase I635_08100 ENOG4105HF0 Membrane I635_08105 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I635_08145 ENOG4105CHR reductase I635_08155 ENOG4105C22 threonyL-tRNA synthetase I635_08160 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) I635_08165 ENOG41082NX 50s ribosomal protein l35 I635_08170 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) I635_08175 ENOG4105CJT Mannose-1-phosphate guanylyltransferase I635_08180 ENOG4105D3Q Sugar transferase I635_08190 ENOG4105DAY polysaccharide export protein I635_08195 ENOG4108QV3 biosynthesis protein I635_08200 ENOG4108RB3 Capsular polysaccharide biosynthesis protein I635_08255 ENOG4105K64 Glycosyl transferase, family 2 I635_08270 ENOG4108SHN Glycosyl transferase, family 2 I635_08275 ENOG4107T8Q Glycosyl transferase (Group 1 I635_08285 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family I635_08300 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) I635_08305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) I635_08310 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) I635_08320 ENOG4108Z66 YbaK ebsC protein I635_08330 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) I635_08335 ENOG4108WBT adenosyltransferase I635_08345 ENOG4108JA2 transcriptioN-repair coupling factor I635_08355 ENOG4105D60 lipoprotein releasing system transmembrane protein I635_08380 ENOG4105CGK Exodeoxyribonuclease III I635_08415 ENOG4105DNH Major Facilitator I635_08425 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) I635_08450 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase I635_08460 ENOG4108UKI Enoyl-CoA hydratase I635_08465 ENOG4107QX3 carboxylase I635_08470 ENOG4105C1G acyl-Coa dehydrogenase I635_08475 ENOG4108Z6Z Transcriptional regulator I635_08480 ENOG4105CHU acetyl-coa acetyltransferase I635_08495 ENOG4105BZU Histidine kinase I635_08505 ENOG4105CJB Exodeoxyribonuclease I I635_08550 ENOG4105CNU cell division protein FtsK I635_08595 ENOG4105WH1 Two component transcriptional regulator luxr family I635_08610 ENOG4105WXW Antirepressor I635_08680 ENOG4105CDU Replicative dna helicase I635_08770 ENOG4108TFU terminase (Small subunit) I635_08870 ENOG4105BZU Histidine kinase I635_08875 ENOG4105D44 asparaginase I635_08920 ENOG4105CQ7 ATP-dependent helicase I635_08935 ENOG4105DR4 Methyltransferase I635_08940 ENOG4108JA1 polyketide synthase I635_08945 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I635_08950 ENOG4107RZZ dna polymerase iii epsilon subunit I635_08960 ENOG4108M8H domain protein I635_08970 ENOG4105D60 lipoprotein releasing system transmembrane protein I635_08975 ENOG4105CK2 sodium dicarboxylate symporter I635_08985 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) I635_08995 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) I635_09010 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) I635_09015 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) I635_09020 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit I635_09025 ENOG4107YB6 acetyltransferase, (GNAT) family I635_09040 ENOG4105C03 ribonuclease I635_09045 ENOG4105EI2 Pseudouridine synthase I635_09055 ENOG4108UHJ MAF-like protein I635_09060 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein I635_09065 ENOG4105VGS 50s ribosomal protein l32 I635_09070 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) I635_09075 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) I635_09080 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase I635_09085 ENOG4105CHR reductase I635_09090 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) I635_09095 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) I635_09105 ENOG4105HHA aminodeoxychorismate lyase I635_09110 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) I635_09115 ENOG4107QRG dna polymerase iii I635_09120 ENOG4105F8V Hydrolase, tatD family I635_09135 ENOG4105BZU Histidine kinase I635_09155 ENOG4105CHR reductase I635_09160 ENOG4108J2P Alpha beta hydrolase fold I635_09170 ENOG4105CHU acetyl-coa acetyltransferase I635_09175 ENOG4105CSU acyl-Coa dehydrogenase I635_09190 ENOG4105DKT Transcriptional regulator I635_09195 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 I635_09205 ENOG4105DEI Mannitol dehydrogenase I635_09230 ENOG4105D8X mechanosensitive ion channel I635_09235 ENOG4105D05 Receptor I635_09240 ENOG4105KZX Pterin carbinolamine dehydratase I635_09245 ENOG4105BZU Histidine kinase I635_09250 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_09255 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) I635_09260 ENOG4105CHV Transcription elongation factor NusA I635_09265 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) I635_09270 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) I635_09275 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) I635_09285 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) I635_09290 ENOG4105FE9 pseudouridine synthase I635_09300 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase I635_09340 ENOG4105D3R alkyl hydroperoxide reductase I635_09385 ENOG4105CCT upf0313 protein I635_09400 ENOG4105D05 Receptor I635_09405 ENOG4107QN2 dihydrolipoyl dehydrogenase I635_09415 ENOG4105VNH ABC transporter solute-binding protein I635_09425 ENOG4108VGW abc transporter atp-binding protein I635_09430 ENOG4108T9J Cdp-alcohol phosphatidyltransferase I635_09490 ENOG4105E5H Transposase I635_09500 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I635_09505 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) I635_09510 ENOG4108Z1B Cyclase dehydrase I635_09515 ENOG4105VDB UPF0125 protein I635_09545 ENOG4107RDJ Sulfotransferase I635_09555 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) I635_09560 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) I635_09600 ENOG4105EZE Cupin 4 family protein I635_09610 ENOG4107QTF adenylosuccinate lyase I635_09615 ENOG41075W9 High frequency lysogenization protein HflD homolog I635_09620 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) I635_09625 ENOG4108R99 pseudouridine synthase I635_09635 ENOG4105VEQ Cold shock protein I635_09640 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) I635_09645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit I635_09650 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) I635_09655 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate I635_09660 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) I635_09665 ENOG4105C3M thioredoxin reductase I635_09670 ENOG4105PQ6 UPF0208 membrane protein I635_09675 ENOG4105GPY SprT protein I635_09680 ENOG4105D07 Signal peptide peptidase, SppA I635_09695 ENOG41069NU Nitroreductase I635_09705 ENOG4105HDK L-asparaginase I635_09710 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) I635_09715 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) I635_09720 ENOG4108Z43 UPF0250 protein I635_09725 ENOG4105DZ1 carboxypeptidase I635_09730 ENOG4105K6T rare lipoprotein A I635_09735 ENOG4105CNI cell division protein FtsW I635_09740 ENOG4105CJN penicillin-binding protein I635_09745 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) I635_09750 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) I635_09760 ENOG4105DJF DNA polymerase III, delta' subunit I635_09765 ENOG4108U2H Rare lipoprotein B I635_09770 ENOG4105C8T Leucyl-tRNA synthetase I635_09785 ENOG4105DAN ATP-dependent protease I635_09790 ENOG4107R6F Alpha Beta Hydrolase Fold protein I635_09795 ENOG4105BZU Histidine kinase I635_09805 ENOG4105HBR Rna-binding protein I635_09810 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) I635_09815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) I635_09820 ENOG4105EEI dihydropteroate synthase I635_09825 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) I635_09830 ENOG4105CP7 Triose-phosphate isomerase I635_09840 ENOG4105BZU Histidine kinase I635_09870 ENOG4105CHR reductase I635_09875 ENOG4108KP7 hydrolase I635_09905 ENOG4105CK7 Sodium proline symporter I635_09915 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) I635_09930 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) I635_10040 ENOG4105JAB phenazine biosynthesis protein, phzf family I635_10130 ENOG410822N TonB family I635_10135 ENOG4105E5H Transposase I635_10170 ENOG4105EXN Sulfate transport protein CysZ I635_10175 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) I635_10180 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) I635_10185 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) I635_10205 ENOG4105BZ1 (ABC) transporter I635_10210 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) I635_10215 ENOG4105W49 UPF0434 protein I635_10220 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) I635_10230 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) I635_10245 ENOG4105CUZ uba thif-type nad fad binding protein I635_10250 ENOG4105CHF Glutathione S-transferase I635_10255 ENOG4105EUB pirin domain protein I635_10260 ENOG4107QKV phosphomannomutase I635_10270 ENOG4105BZN citrate synthase I635_10275 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit I635_10280 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein I635_10285 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) I635_10290 ENOG4105E33 succinate dehydrogenase I635_10295 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 I635_10300 ENOG4105C7S Dehydrogenase I635_10305 ENOG4105CMV Succinyl-CoA synthetase subunit beta I635_10310 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha I635_10320 ENOG4105QV4 Tryptophan halogenase I635_10335 ENOG4108NRW Phospholipase, patatin family I635_10355 ENOG4108IUK alpha amylase, catalytic I635_10370 ENOG4105ETE Transcriptional regulator (LacI family I635_10375 ENOG4105CX6 glutaminyL-tRNA synthetase I635_10380 ENOG4105UBK short-chain dehydrogenase reductase I635_10385 ENOG4108M0H Extracellular lipase I635_10390 ENOG4107SQI penicillin amidase I635_10395 ENOG4105ERU peptidase I635_10410 ENOG4107QNR UPF0135 protein I635_10415 ENOG4106371 Methyltransferase I635_10420 ENOG4105C5I Dehydrogenase I635_10425 ENOG4108V06 Glutathione peroxidase I635_10430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase I635_10440 ENOG4105C1G acyl-Coa dehydrogenase I635_10445 ENOG4105E39 Enoyl-CoA hydratase I635_10455 ENOG4105DHI Methyltransferase I635_10460 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase I635_10465 ENOG4105E68 Sulfatase I635_10470 ENOG4105YDX UPF0352 protein I635_10475 ENOG4106V8H Nucleoid-associated protein I635_10505 ENOG4108HRK Histidine kinase I635_10510 ENOG4108VAC response regulator I635_10515 ENOG4105CTQ phosphohexokinase I635_10530 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) I635_10545 ENOG4105BZU Histidine kinase I635_10555 ENOG4105C72 UPF0176 protein I635_10565 ENOG4105C1J atp-dependent rna helicase I635_10575 ENOG4105D6N CoA-transferase, subunit a I635_10580 ENOG4105F04 LysR family Transcriptional regulator I635_10595 ENOG4107R11 Transcriptional regulator I635_10600 ENOG4105EJQ L-serine dehydratase I635_10610 ENOG4105CRQ synthase (Component I) I635_10625 ENOG4105CGY Dna recombination protein I635_10630 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin I635_10640 ENOG4105CPP Dehydrogenase, E1 component I635_10650 ENOG4105D6S protein involved in catabolism of external DNA I635_10660 ENOG4105C29 acyl-CoA thioesterase I635_10665 ENOG4108Z0R Transferase I635_10670 ENOG4105C5R Aminotransferase I635_10680 ENOG4108ZGC gaf domain protein I635_10690 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) I635_10695 ENOG4105CN1 protease I635_10700 ENOG4105C8J )-transporter I635_10705 ENOG4105DFD Na H antiporter I635_10710 ENOG4105CD8 aminopeptidase N I635_10725 ENOG4105D25 secreted protein I635_10740 ENOG4105C7I Dehydrogenase I635_10745 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) I635_10750 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) I635_10760 ENOG4105C5H ABC transporter I635_10770 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) I635_10775 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) I635_10785 ENOG4105CVP deoxyribo-dipyrimidine photolyase I635_10790 ENOG4105CVP deoxyribo-dipyrimidine photolyase I635_10795 ENOG4105CVP deoxyribo-dipyrimidine photolyase I635_10800 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein I635_10815 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I635_10825 ENOG41080IJ Diacylglycerol kinase I635_10830 ENOG41081QV Universal stress protein I635_10840 ENOG4105CBC glutamate synthase I635_10845 ENOG4105CKD glutathione-regulated potassium-efflux system protein I635_10850 ENOG4108UQY Iron-storage protein I635_10865 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i I635_10880 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) I635_10905 ENOG4105DS0 Transcriptional regulator, Crp Fnr family I635_10910 ENOG4105Q9Y Universal stress protein I635_10915 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) I635_10920 ENOG4105D78 K07001 NTE family protein I635_10940 ENOG4105CCF Lysine exporter protein (Lyse ygga) I635_10945 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) I635_10950 ENOG4105KHC sulfurtransferase I635_10955 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) I635_10960 ENOG4106IUH DTW domain containing protein I635_10970 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) I635_10975 ENOG4105WH1 Two component transcriptional regulator luxr family I635_10980 ENOG4105CHM Aminotransferase I635_10995 ENOG4108VGI doxx family I635_11000 ENOG4105CC0 LysR family Transcriptional regulator I635_11015 ENOG4108MN8 Membrane I635_11020 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) I635_11035 ENOG4108Z0T Part of a sulfur-relay system (By similarity) I635_11055 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) I635_11060 ENOG4105WMR Protein CrcB homolog I635_11065 ENOG4105D1H recombination factor protein RarA I635_11075 ENOG4105CNU cell division protein FtsK I635_11080 ENOG4105EW9 transcriptional regulator AsnC family I635_11085 ENOG4105DCF alanine dehydrogenase I635_11090 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) I635_11095 ENOG4105CFV Tetratricopeptide repeat protein I635_11110 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) I635_11115 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) I635_11120 ENOG4105CAT Cytidine monophosphate kinase I635_11125 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase I635_11130 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) I635_11135 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I635_11140 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I635_11145 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I635_11150 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I635_11155 ENOG4105XPH Ferredoxin I635_11170 ENOG4105BZU Histidine kinase I635_11180 ENOG4105C8V SAICAR synthetase I635_11185 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I635_11190 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) I635_11200 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I635_11210 ENOG4105ERG peptidase m48, ste24p I635_11220 ENOG4105K89 arsenate reductase I635_11225 ENOG4105CS1 NAD(P)H quinone oxidoreductase I635_11235 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) I635_11245 ENOG4105CXB phosphoribosylaminoimidazole synthetase I635_11250 ENOG4108V3E phosphoribosylglycinamide formyltransferase I635_11260 ENOG4107QPN acyl-Coa dehydrogenase I635_11275 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) I635_11280 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) I635_11285 ENOG4105DBI uridine monophosphokinase I635_11290 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase I635_11295 ENOG4105C3Q Glycosyl transferase, family 2 I635_11300 ENOG4107QW3 Sucrose phosphorylase I635_11305 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) I635_11310 ENOG4105CVM Molybdenum cofactor synthesis domain protein I635_11315 ENOG4107QI1 Mate efflux family protein I635_11335 ENOG4105C6T cysteine synthase I635_11365 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system I635_11405 ENOG4105JAB phenazine biosynthesis protein, phzf family I635_11410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I635_11415 ENOG41060WC Enoyl-CoA hydratase I635_11435 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) I635_11445 ENOG4105C28 cystathionine I635_11460 ENOG4105CGF Aromatic amino acid aminotransferase I635_11470 ENOG4108UPT UPF0178 protein I635_11475 ENOG4105CHR reductase I635_11480 ENOG4105CHR reductase I635_11485 ENOG4105CSU acyl-Coa dehydrogenase I635_11490 ENOG4105FTV AraC Family Transcriptional Regulator I635_11505 ENOG4105EKQ RNA-directed DNA polymerase I635_11520 ENOG4105ENT Efflux transporter rnd family, mfp subunit I635_11530 ENOG4105C10 Electron transfer flavoprotein I635_11535 ENOG4105BZJ Electron transfer flavoprotein I635_11540 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase I635_11545 ENOG4108YX2 DNA-binding protein I635_11550 ENOG4105EV9 Alpha Beta Hydrolase I635_11560 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) I635_11565 ENOG4108NVR Methyl-accepting chemotaxis I635_11570 ENOG41090R7 Ferric uptake I635_11585 ENOG4105P4J Allophanate hydrolase, subunit 1 I635_11590 ENOG4105E7W lamb ycsf family protein I635_11595 ENOG4105QNR S1 RNA binding domain protein I635_11600 ENOG4108UKZ OsmC family I635_11605 ENOG4105ENT Efflux transporter rnd family, mfp subunit I635_11630 ENOG4105CHM Aminotransferase I635_11635 ENOG4105DK2 UPF0207 protein I635_11640 ENOG4105DK2 UPF0207 protein I635_11650 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding I635_11655 ENOG4108XHQ (2Fe-2S)-binding domain protein I635_11680 ENOG4105ENX hydrolase I635_11685 ENOG4105CF7 AraC family transcriptional regulator I635_11695 ENOG4105DK2 UPF0207 protein I635_11700 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein I635_11725 ENOG4105K5B UPF0225 protein I635_11730 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein I635_11740 ENOG4105C1G acyl-Coa dehydrogenase I635_11750 ENOG4107ZSV Receptor I635_11770 ENOG4105D4P Coproporphyrinogen iii oxidase I635_11775 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) I635_11780 ENOG4105E0C molybdate abc transporter I635_11790 ENOG4108ZAF Molybdopterin I635_11795 ENOG4105M00 molybdopterin converting factor, subunit 1 I635_11800 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) I635_11805 ENOG4108RIR Molybdenum cofactor biosynthesis protein I635_11810 ENOG4105D06 uba thif-type nad fad binding protein I635_11825 ENOG4105KRQ Addiction module toxin, Txe YoeB family I635_11845 ENOG4105EG6 Saccharopine dehydrogenase I635_11850 ENOG4105CIH Imidazole acetol-phosphate transaminase I635_11865 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) I635_11870 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I635_11880 ENOG4107AQZ Membrane I635_11895 ENOG4107QYX exodeoxyribonuclease v alpha I635_11900 ENOG4107QKA exodeoxyribonuclease V beta I635_11905 ENOG4105DSY exodeoxyribonuclease V, gamma I635_11925 ENOG4108IQE Amp-dependent synthetase and ligase I635_11950 ENOG4105CVI Transcriptional regulator I635_11970 ENOG41082SX arsR family transcriptional regulator I635_11980 ENOG4105DUM transcriptional regulator, lysR family I635_11990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_12035 ENOG4105DK2 UPF0207 protein I635_12060 ENOG4105VUT cytoplasmic protein I635_12075 ENOG4105BZG amino acid carrier protein I635_12095 ENOG4105E0X reductase I635_12100 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) I635_12110 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) I635_12115 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) I635_12120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I635_12125 ENOG4105DSB aldose 1-epimerase I635_12130 ENOG4108UHU Aldolase I635_12135 ENOG4105CHC glucokinase (EC 2.7.1.2) I635_12140 ENOG4105C01 Dihydroxy-acid dehydratase I635_12145 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I635_12150 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I635_12155 ENOG4106KNT transcriptional regulator I635_12160 ENOG4105CA9 Pyruvate kinase I635_12175 ENOG4105CSU acyl-Coa dehydrogenase I635_12180 ENOG4105BZJ Electron transfer flavoprotein I635_12185 ENOG4105C10 Electron transfer flavoprotein I635_12190 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase I635_12195 ENOG4107QWE )-transporter I635_12205 ENOG4108UHU Aldolase I635_12210 ENOG4105CHC glucokinase (EC 2.7.1.2) I635_12215 ENOG4105C01 Dihydroxy-acid dehydratase I635_12220 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I635_12225 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I635_12230 ENOG4106KNT transcriptional regulator I635_12235 ENOG4105CA9 Pyruvate kinase I635_12240 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I635_12260 ENOG4105K3G Periplasmic Protein I635_12290 ENOG4105EIG urea carboxylase-associated protein 1 I635_12330 ENOG4108K8S endonuclease I I635_12335 ENOG4105C8Q Methyl-accepting chemotaxis I635_12350 ENOG4108W5M transcriptional regulator I635_12355 ENOG4108I6A alcohol dehydrogenase I635_12360 ENOG4105BZU Histidine kinase I635_12370 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_12375 ENOG4105BZU Histidine kinase I635_12465 ENOG4105C8P )-transporter I635_12470 ENOG4105DHP deoxycytidine triphosphate deaminase I635_12475 ENOG4105D1F ATP-binding protein I635_12480 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) I635_12490 ENOG4105D1A Methyltransferase I635_12495 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) I635_12500 ENOG4105E9H Lytic Murein transglycosylase I635_12525 ENOG4105C8N cysteinyl-tRNA synthetase I635_12530 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) I635_12535 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) I635_12545 ENOG4107S78 Band 7 protein I635_12560 ENOG4105KVH Transcriptional regulator I635_12575 ENOG4105CIS alcohol dehydrogenase I635_12605 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase I635_12615 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase I635_12620 ENOG4105E96 Colicin v production protein I635_12625 ENOG4108S3P Sporulation domain protein I635_12630 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase I635_12635 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) I635_12650 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) I635_12655 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) I635_12660 ENOG4105MP9 class II Aldolase I635_12675 ENOG4105YAJ CopG Arc MetJ I635_12685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) I635_12690 ENOG4105CEY Amp-dependent synthetase and ligase I635_12700 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) I635_12735 ENOG4108Z6Z Transcriptional regulator I635_12740 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family I635_12765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr I635_12770 ENOG4105DKW ABC transporter I635_12775 ENOG4105CRW Short chain fatty acid transporter I635_12780 ENOG4105BZU Histidine kinase I635_12805 ENOG4108BPE -transporting atpase I635_12835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I635_12860 ENOG4105D8T Acyltransferase I635_12870 ENOG4106MP8 UPF0754 membrane protein I635_12895 ENOG4105CUG Oligopeptidase b I635_12900 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) I635_12905 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) I635_12910 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) I635_12915 ENOG4108428 Inherit from COG: -acetyltransferase I635_12925 ENOG4108ZZ3 UPF0260 protein I635_12930 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase I635_12940 ENOG4105VNG YcgL domain-containing protein I635_12945 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) I635_12950 ENOG4105CEY Amp-dependent synthetase and ligase I635_12955 ENOG410832A alpha/beta hydrolase fold I635_12970 ENOG41072GX Peptidase M22 Glycoprotease I635_12975 ENOG4105DVT helicase I635_13025 ENOG4105D05 Receptor I635_13035 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) I635_13040 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) I635_13045 ENOG4105CIH Imidazole acetol-phosphate transaminase I635_13050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase I635_13055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) I635_13060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase I635_13065 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) I635_13070 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase I635_13085 ENOG4105S64 Formate nitrite transporter I635_13090 ENOG4107RAN Peptidase, M16 I635_13095 ENOG4105C3F Signal peptidase i I635_13100 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I635_13120 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) I635_13125 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) I635_13130 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) I635_13145 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) I635_13150 ENOG4107QMP dna polymerase iii subunits gamma and tau I635_13155 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) I635_13165 ENOG4105E18 UPF0276 protein I635_13175 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) I635_13190 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase I635_13210 ENOG4105CXG d-lactate dehydrogenase I635_13215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit I635_13220 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase I635_13225 ENOG4105C34 Pseudouridine synthase I635_13230 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane I635_13240 ENOG4105K6V RNA polymerase I635_13255 ENOG4105EMU Dehydrogenase I635_13270 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase I635_13275 ENOG4106VK6 Flagellar motor protein I635_13280 ENOG4105E14 MotA TolQ exbB proton channel I635_13290 ENOG4105CTB Polyprenyl synthetase I635_13295 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) I635_13300 ENOG4108ZAI phosphatidylglycerophosphatase a I635_13305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) I635_13310 ENOG4107YIM Involved in the transcription termination process (By similarity) I635_13315 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) I635_13330 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) I635_13335 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) I635_13340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) I635_13345 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I635_13350 ENOG4105C5H ABC transporter I635_13360 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) I635_13370 ENOG4105EAC phosphoserine phosphatase I635_13380 ENOG4105EYA deoxyribonuclease I635_13385 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) I635_13395 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) I635_13400 ENOG4105C3F Signal peptidase i I635_13405 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) I635_13425 ENOG4105EMN RNA polymerase sigma factor I635_13430 ENOG4108IYU L-aspartate oxidase I635_13445 ENOG4105Y75 tpr repeat protein I635_13450 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) I635_13455 ENOG4108YZY peptidylprolyl cis-trans isomerase I635_13460 ENOG4108YZA Nitrogen regulatory protein pii I635_13465 ENOG4107RA1 nh(3)-dependent nad( ) synthetase I635_13525 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) I635_13530 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase I635_13535 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) I635_13540 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) I635_13545 ENOG4105DTN riboflavin biosynthesis protein ribF I635_13550 ENOG4105CJR Integral membrane protein (MviN I635_13555 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) I635_13575 ENOG4105C09 Bile acid I635_13595 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) I635_13605 ENOG4105EIN peptidylprolyl cis-trans isomerase I635_13610 ENOG4105K70 DNA-binding protein I635_13620 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) I635_13625 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) I635_13630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) I635_13635 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation I635_13640 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) I635_13650 ENOG4108R96 Methyltransferase, YaeB family I635_13655 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) I635_13660 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) I635_13665 ENOG4105HDD phospholipase I635_13670 ENOG4105DGU Histone deacetylase I635_13675 ENOG4108NVR Methyl-accepting chemotaxis I635_13680 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) I635_13685 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) I635_13690 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) I635_13705 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) I635_13710 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) I635_13715 ENOG4105N21 Membrane I635_13720 ENOG4105CUT histidyl-tRNA synthetase I635_13725 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) I635_13740 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs I635_13745 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) I635_13750 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) I635_13760 ENOG4108Z4V iron-sulfur cluster assembly I635_13765 ENOG4105C9B Cysteine desulfurase I635_13770 ENOG4105JRK feS assembly protein SufD I635_13775 ENOG4105C3K feS assembly ATPase SufC I635_13785 ENOG4105C3J Cysteine desulfurase I635_13795 ENOG4105CT3 Monooxygenase I635_13800 ENOG4105D7W serine acetyltransferase I635_13805 ENOG4105CVS RNA methyltransferase TrmH family, group 1 I635_13825 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) I635_13830 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) I635_13835 ENOG4105VIE preprotein translocase, subunit YajC I635_13840 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) I635_13845 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) I635_13860 ENOG4108P9J Phage shock protein A I635_13885 ENOG4106032 Glutathionylspermidine synthase I635_13900 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) I635_13915 ENOG4105CSV Glutaminase I635_13920 ENOG4105G6Z alkaline phosphatase I635_13930 ENOG4107RET Isocitrate lyase I635_13975 ENOG4105C0H protease I635_13995 ENOG4107T8Q Glycosyl transferase (Group 1 I635_14020 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase I635_14050 ENOG4105EXC Acyl-transferase I635_14055 ENOG4105CAQ asparagine synthetase I635_14060 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) I635_14100 ENOG4105CAQ asparagine synthetase I635_14120 ENOG4105D3Q Sugar transferase I635_14135 ENOG4108QV3 biosynthesis protein I635_14175 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) I635_14205 ENOG4105D1S lipid A biosynthesis I635_14220 ENOG4107QPN acyl-Coa dehydrogenase I635_14235 ENOG4105BZU Histidine kinase I635_14240 ENOG4107104 thymidine kinase I635_14255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) I635_14285 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) I635_14290 ENOG4108RWN rrna methyltransferase I635_14295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I635_14310 ENOG4105C26 Dehydrogenase I635_14315 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) I635_14330 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) I635_14355 ENOG4105CSU acyl-Coa dehydrogenase I635_14385 ENOG4105E3W Two component transcriptional regulator (Winged helix family I635_14390 ENOG4105E0F Histidine kinase I635_14400 ENOG4105NA0 Transcriptional regulator I635_14405 ENOG410822N TonB family I635_14420 ENOG4107XDR Lactoylglutathione lyase I635_14430 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit I635_14435 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding I635_14440 ENOG4105C7W Xanthine dehydrogenase I635_14460 ENOG4105CHR reductase I635_14465 ENOG4105EMU Dehydrogenase I635_14470 ENOG4107RKG DJ-1/PfpI family I635_14475 ENOG4107U9T Pfam:Ribonuclease_BN I635_14485 ENOG4108VWS Yaeq family I635_14515 ENOG4105S8Q sugar efflux transporter I635_14530 ENOG4105C9U ATP-dependent DNA helicase RecQ I635_14550 ENOG4105BZU Histidine kinase I635_14560 ENOG4105BZU Histidine kinase I635_14565 ENOG4105D8V Glucose sorbosone dehydrogenase I635_14570 ENOG4105YAJ CopG Arc MetJ I635_14580 ENOG4105XJC Two component transcriptional regulator (Winged helix family I635_14585 ENOG4105BZU Histidine kinase I635_14605 ENOG4105D82 Glutamate dehydrogenase I635_14610 ENOG4105NXH GreA GreB family elongation factor I635_14645 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein I635_14720 ENOG4105GAV receptor I635_14745 ENOG4105PGM cation diffusion facilitator family transporter I635_14755 ENOG4105PGM cation diffusion facilitator family transporter I635_14765 ENOG4105E5H Transposase I635_14780 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) I635_14785 ENOG4108JUA Transcriptional regulator I635_14800 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor I635_14805 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) I635_14810 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) I635_14815 ENOG4105CE4 GlcNAc 6-P deacetylase I635_14820 ENOG4105RD7 BadF BadG BcrA BcrD I635_14830 ENOG4105DAA L-lactate I635_14855 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family I635_14860 ENOG4105D0A hydroxylase I635_14865 ENOG4107RAQ aminopeptidase I635_14875 ENOG4108RVA ribokinase I635_14890 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase I635_14895 ENOG4105E66 phosphoriboisomerase A I635_14900 ENOG4108JQ1 Dehydrogenase I635_14920 ENOG4105XZD Fe-S protein I635_14950 ENOG4107QN2 dihydrolipoyl dehydrogenase I635_14955 ENOG4107QSN dihydrolipoamide acetyltransferase I635_14960 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) I635_14965 ENOG41073TP transcriptional regulator I635_14975 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase I635_14980 ENOG4108WIW Aspartyl protease I635_14985 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase I635_14995 ENOG4105D7Q type ii secretion system I635_15000 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) I635_15010 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) I635_15015 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) I635_15020 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) I635_15025 ENOG4105M6F mutator MutT protein I635_15030 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving I635_15035 ENOG4105DR5 peptidase I635_15040 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) I635_15045 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) I635_15050 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) I635_15055 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) I635_15060 ENOG4105CPF Cell wall formation (By similarity) I635_15065 ENOG4105DFU Cell wall formation (By similarity) I635_15070 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) I635_15075 ENOG4105CNI cell division protein FtsW I635_15080 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) I635_15085 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) I635_15090 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) I635_15095 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) I635_15100 ENOG4105CJN penicillin-binding protein I635_15105 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) I635_15110 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) I635_15115 ENOG4108V6E Cell division protein mraZ I635_15165 ENOG4105EHV domain protein I635_15180 ENOG4105BZU Histidine kinase I635_15190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_15195 ENOG4105BZU Histidine kinase I635_15230 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) I635_15235 ENOG4105D7Z glutathione synthase I635_15240 ENOG4108UJU UPF0301 protein I635_15245 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) I635_15255 ENOG4105CZX twitching motility protein I635_15260 ENOG4105CZX twitching motility protein I635_15265 ENOG4105DFA alanine racemase domain protein I635_15270 ENOG4105II7 pyrroline-5-carboxylate reductase I635_15275 ENOG4108VIA integral membrane protein I635_15285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I635_15300 ENOG4108SHQ Glutathione S-transferase I635_15305 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I635_15310 ENOG4108Z9K Osmotically inducible protein I635_15330 ENOG4108UMN azlc family I635_15340 ENOG4105F27 Major Facilitator I635_15345 ENOG4105VFU Rna-binding protein I635_15350 ENOG4105D1Q UPF0246 protein I635_15365 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) I635_15370 ENOG4107QP8 phosphohexose isomerase I635_15380 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) I635_15385 ENOG4105D98 threonine synthase I635_15390 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) I635_15405 ENOG4105CC0 LysR family Transcriptional regulator I635_15420 ENOG41082YX Transcriptional regulator, arsr family I635_15430 ENOG4105CAU Arsenical resistance protein, ArsH I635_15435 ENOG4105D6J arsenicaL-resistance protein I635_15440 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) I635_15445 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) I635_15480 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) I635_15510 ENOG4105E3Q saccharopine dehydrogenase I635_15525 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) I635_15530 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) I635_15535 ENOG41082RQ UPF0102 protein I635_15540 ENOG4105CPK Glycosyl transferase (Group 1 I635_15545 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) I635_15550 ENOG4105W4M Transport-associated protein I635_15570 ENOG4105BZU Histidine kinase I635_15600 ENOG4105CR4 methylisocitrate lyase I635_15605 ENOG4105BZN citrate synthase I635_15610 ENOG4108I0Z Aconitate hydratase I635_15615 ENOG4105C7F AcnD-accessory protein PrpF I635_15620 ENOG4105BZU Histidine kinase I635_15665 ENOG4105BZU Histidine kinase I635_15670 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase I635_15675 ENOG4105CBC glutamate synthase I635_15680 ENOG4105BZ8 glutamate synthase I635_15695 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) I635_15700 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) I635_15705 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) I635_15710 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) I635_15725 ENOG4105CJP fad dependent oxidoreductase I635_15730 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) I635_15740 ENOG4108K5P (LipO)protein I635_15745 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) I635_15750 ENOG4105EDR glucose galactose transporter I635_15760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I635_15780 ENOG4107MKT Stringent starvation protein a I635_15785 ENOG4108YX9 iron--sulfur cluster insertion protein erpA I635_15795 ENOG4105CSR polyphosphate kinase 2 I635_15800 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) I635_15805 ENOG4107QMS site-determining protein I635_15810 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) I635_15815 ENOG4105C9Q fumarate hydratase class II I635_15850 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) I635_15855 ENOG4105CHM Aminotransferase I635_15865 ENOG4105CI3 gtp-binding protein typa I635_15875 ENOG4105C5F glutamine synthetase I635_15885 ENOG4105CUX Signal transduction histidine kinase I635_15890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_15895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_15900 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase I635_15905 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) I635_15940 ENOG4105BZU Histidine kinase I635_15945 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) I635_15950 ENOG4105MYG DNA polymerase iii, chi subunit I635_15955 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) I635_15960 ENOG4108M8S permease YjgP YjgQ family protein I635_15965 ENOG4108K5H permease YjgP YjgQ family protein I635_15980 ENOG4105K6V RNA polymerase I635_16050 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I635_16065 ENOG4105M03 Domain of unknown function (DUF955) I635_16180 ENOG4105CNT hydrolase family 2 I635_16190 ENOG4105CXK mandelate racemase muconate lactonizing I635_16195 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) I635_16210 ENOG410620I Diguanylate cyclase I635_16240 ENOG4105BZU Histidine kinase I635_16260 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) I635_16265 ENOG4105EHG Permease protein I635_16270 ENOG4107R4I Periplasmic binding protein I635_16280 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) I635_16290 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) I635_16295 ENOG4105EMK carboxylate amino acid amine transporter I635_16320 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) I635_16330 ENOG4105CY0 Metallo-Beta-Lactamase I635_16345 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) I635_16360 ENOG4108N2Y auxin Efflux I635_16370 ENOG4105DZG Dehydrogenase I635_16390 ENOG4105CJ1 ABC, transporter I635_16400 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) I635_16405 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) I635_16410 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) I635_16415 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d I635_16420 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E I635_16450 ENOG4105BZU Histidine kinase I635_16470 ENOG4105WH1 Two component transcriptional regulator luxr family I635_16475 ENOG4105BZU Histidine kinase I635_16480 ENOG4105JQN Transcriptional regulator I635_16485 ENOG4105C26 Dehydrogenase I635_16490 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase I635_16495 ENOG4105C94 Transporter I635_16510 ENOG4107ZSV Receptor I635_16520 ENOG4105CC0 LysR family Transcriptional regulator I635_16525 ENOG4105DMF Dehydrogenase I635_16530 ENOG4105CXG d-lactate dehydrogenase I635_16535 ENOG41086KC Transcriptional regulator I635_16540 ENOG4105P8Q Curli production assembly transport component CsgG I635_16570 ENOG4105WH1 Two component transcriptional regulator luxr family I635_16585 ENOG4105C1J atp-dependent rna helicase I635_16600 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I635_16605 ENOG4105C4M (Ubiquinol oxidase) subunit I I635_16620 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) I635_16640 ENOG4105VW4 glutaredoxin 3 I635_16650 ENOG4105BZU Histidine kinase I635_16700 ENOG4105MZG transcriptional modulator of maze toxin, mazf I635_16715 ENOG4105DC8 reductase I635_16730 ENOG4105BZ9 Cytochrome C oxidase, subunit I I635_16735 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) I635_16755 ENOG4105C4M (Ubiquinol oxidase) subunit I I635_16760 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I635_16795 ENOG4105EGS Mechanosensitive ion channel I635_16810 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) I635_16840 ENOG4105HF0 Membrane I635_16845 ENOG4105CIH Imidazole acetol-phosphate transaminase I635_16860 ENOG4105BZU Histidine kinase I635_16870 ENOG4105CQ2 DNA polymerase I635_16880 ENOG4105CEY Amp-dependent synthetase and ligase I635_16895 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) I635_16900 ENOG4105EJ2 Transcriptional regulator I635_16910 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) I635_16920 ENOG4108RG0 uracil-dna glycosylase I635_16925 ENOG4105BZU Histidine kinase I635_16935 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) I635_16940 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) I635_16965 ENOG4105FM1 phage shock protein C I635_16970 ENOG41087YS Phage shock protein A I635_16980 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) I635_17000 ENOG4105UYK outer membrane protein a I635_17005 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) I635_17010 ENOG4105BZU Histidine kinase I635_17015 ENOG4105C4W S-formylglutathione hydrolase I635_17020 ENOG4106HNH Acyl-transferase I635_17025 ENOG4106HNH Acyl-transferase I635_17030 ENOG4105CUY Mechanosensitive ion channel I635_17045 ENOG4108535 NAD dependent epimerase/dehydratase family I635_17050 ENOG4105C8J )-transporter I635_17065 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) I635_17080 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) I635_17090 ENOG4109015 Biopolymer transport protein exbD tolR I635_17105 ENOG4105EJG cellulose synthase I635_17110 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) I635_17120 ENOG4107QZ7 Cellulose synthase catalytic subunit I635_17135 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) I635_17140 ENOG4105K4T epimerase I635_17150 ENOG4105KWG Pfam:DUF1696 I635_17155 ENOG4105BZU Histidine kinase I635_17170 ENOG4105EFZ amidohydrolase I635_17180 ENOG4105C5X domain protein I635_17190 ENOG4108WAV Transcriptional regulator I635_17195 ENOG4105E7A Glutamine amidotransferase I635_17200 ENOG4108Z12 YiaAB two helix domain-containing protein I635_17220 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease I635_17230 ENOG4105C26 Dehydrogenase I635_17235 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) I635_17240 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) I635_17245 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) I635_17255 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) I635_17260 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) I635_17265 ENOG4108R86 Transcriptional regulator I635_17280 ENOG4105VYA Uncharacterized conserved protein (DUF2132) I635_17285 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) I635_17295 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I635_17305 ENOG4105CJ2 (LipO)protein I635_17310 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) I635_17315 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I635_17320 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I635_17325 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I635_17330 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I635_17335 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) I635_17340 ENOG4105RKW reductase (By I635_17345 ENOG4108V1T peptidylprolyl cis-trans isomerase I635_17350 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) I635_17370 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) I635_17375 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) I635_17400 ENOG4105DBI uridine monophosphokinase I635_17405 ENOG4105D9N nucleoside I635_17425 ENOG4105BZU Histidine kinase I635_17430 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) I635_17435 ENOG4108IJ8 ABC transporter I635_17440 ENOG4107QN1 sodium solute I635_17450 ENOG4105BZU Histidine kinase I635_17460 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I635_17470 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I635_17485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) I635_17500 ENOG4105CPC Aldo Keto reductase I635_17525 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I635_17530 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) I635_17535 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase I635_17540 ENOG4105D4A Cell wall formation (By similarity) I635_17545 ENOG4108N3W hemolysin secretion protein I635_17570 ENOG4108JJA ABC, transporter I635_17575 ENOG41063Z6 transcriptional regulator, lysR family I635_17605 ENOG4105C1B dTDP-glucose 4-6-dehydratase I635_17615 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase I635_17620 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) I635_17640 ENOG4107RDJ Sulfotransferase I635_17770 ENOG4105E5H Transposase I635_17790 ENOG4105E5H Transposase I635_17840 ENOG41084HI prevent-host-death family I635_17845 ENOG4108ZT0 50S ribosomal protein l17 I635_17850 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I635_17855 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) I635_17860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) I635_17865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits I635_17870 ENOG41067V7 50S ribosomal protein L36 I635_17875 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) I635_17880 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) I635_17885 ENOG4105VPB 50S ribosomal protein L30 I635_17890 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) I635_17895 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) I635_17900 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) I635_17905 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) I635_17910 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) I635_17915 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits I635_17920 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) I635_17925 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) I635_17930 ENOG4105BZU Histidine kinase I635_17940 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I635_17950 ENOG4105C2N RNA methyltransferase TrmH family group 3 I635_17955 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) I635_18000 ENOG4108UV7 flagellar protein motX I635_18010 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) I635_18015 ENOG4107QK7 reductase I635_18030 ENOG4107VAM peptidase, m28 I635_18040 ENOG4105BZU Histidine kinase I635_18050 ENOG4105C4M (Ubiquinol oxidase) subunit I I635_18055 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I635_18065 ENOG4108XM1 transcriptional regulator AsnC family I635_18075 ENOG4105VEQ Cold shock protein I635_18080 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) I635_18100 ENOG4105DGW oligopeptidase A I635_18105 ENOG4107YTP response regulator receiver protein I635_18115 ENOG4105BZU Histidine kinase I635_18120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I635_18125 ENOG4105DC8 reductase I635_18130 ENOG4107QY8 reductase I635_18135 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I635_18185 ENOG4105C42 Type I secretion membrane fusion protein (HlyD I635_18190 ENOG4108JJA ABC, transporter I635_18195 ENOG4105WH1 Two component transcriptional regulator luxr family I635_18205 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) I635_18215 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression I635_18220 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) I635_18225 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) I635_18230 ENOG41063M6 Cell Division Protein I635_18235 ENOG4105C25 Primosomal protein n' I635_18240 ENOG4105VFB Binds the 23S rRNA (By similarity) I635_18250 ENOG4105C6K Malic enzyme I635_18255 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) I635_18260 ENOG4105SYT Methylenetetrahydrofolate reductase I635_18265 ENOG4107S2Z UPF0761 membrane protein I635_18285 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) I635_18290 ENOG4105SUU thioesterase domain I635_18295 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I635_18300 ENOG4105D58 Diguanylate phosphodiesterase I635_18305 ENOG4105D58 Diguanylate phosphodiesterase I635_18310 ENOG4105CRP Part of the ABC transporter FtsEX involved in I635_18315 ENOG4105CAK Cell division ATP-binding protein ftsE I635_18320 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) I635_18330 ENOG4106H78 methyltransferase I635_18340 ENOG41076UM multiple antibiotic resistance (MarC)-related protein I635_18355 ENOG4105PW4 Sugar fermentation stimulation protein homolog I635_18360 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters I635_18365 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) I635_18370 ENOG4105DJ0 Poly(A) Polymerase I635_18375 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase I635_18380 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) I635_18385 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) I635_18390 ENOG4105DY8 decarboxylase I635_18410 ENOG4105E3A (ABC) transporter I635_18415 ENOG4105DA5 (ABC) transporter I635_18420 ENOG4105E3W Two component transcriptional regulator (Winged helix family I635_18425 ENOG4105EB3 Histidine kinase I635_18430 ENOG4108ESX Receptor I635_18435 ENOG4107E2E PKHD-type hydroxylase I635_18495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I635_18500 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I635_18505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) I635_18510 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) I635_18515 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) I635_18520 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I635_18525 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I635_18535 ENOG4108VZM 50s ribosomal protein L10 I635_18540 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) I635_18545 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) I635_18565 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) I635_18570 ENOG4105PM1 preprotein translocase subunit SecE I635_18575 ENOG4105BZ1 (ABC) transporter I635_18580 ENOG4105JSC dimethylmenaquinone methyltransferase I635_18585 ENOG4105C9K Endothelin-converting enzyme 1 I635_18595 ENOG4105C1J atp-dependent rna helicase I635_18600 ENOG4105EKE dihydroorotase I635_18605 ENOG4105QNF Outer membrane lipoprotein I635_18610 ENOG4107RGM aldo keto reductase I635_18615 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase I635_18625 ENOG4105DP8 Major facilitator superfamily MFS_1 I635_18630 ENOG4107QW3 Sucrose phosphorylase I635_18640 ENOG4105EUJ GTP cyclohydrolase i I635_18645 ENOG410642E Short chain dehydrogenase I635_18650 ENOG4105DWY Agmatine deiminase I635_18670 ENOG4107QRT dEAD DEAH box helicase I635_18680 ENOG4107T0X DNA ligase I635_18685 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) I635_18690 ENOG4105D7K pfkb domain protein I635_18700 ENOG4105C3R Methionine synthase I635_18705 ENOG4105CYM Glutathione S-transferase I635_18720 ENOG4107IFA Lipase (EC 3.1.1.3) I635_18725 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) I635_18750 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) I635_18755 ENOG4105CFC Transporter I635_18760 ENOG4105EPW hflc protein I635_18765 ENOG4107QJR hflk protein I635_18770 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) I635_18775 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) I635_18780 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) I635_18785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) I635_18790 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I635_18795 ENOG4105K8N protein family UPF0079, ATPase I635_18800 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) I635_18805 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) I635_18815 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) I635_18825 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor I635_18830 ENOG4105MYN Zinc uptake regulation protein I635_18840 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme I635_18845 ENOG4105CDV Ompa motb domain protein I635_18850 ENOG4105CDU Replicative dna helicase I635_18875 ENOG4108RPX mosc domain containing protein I635_18890 ENOG4105K9Q Binds to the 23S rRNA (By similarity) I635_18895 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) I635_18900 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) I635_18925 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor I635_18930 ENOG4105BZU Histidine kinase I635_18935 ENOG4107SDU Methyl-accepting chemotaxis I635_18945 ENOG4105PGM cation diffusion facilitator family transporter I635_18965 ENOG4105DFD Na H antiporter I635_18985 ENOG41060NJ transcriptional regulator I635_18990 ENOG4107QNK )-transporter I635_18995 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein I635_19005 ENOG4105BZU Histidine kinase I635_19015 ENOG4105Q26 Siderophore-interacting protein I635_19020 ENOG4105VDW Csbd family I635_19045 ENOG4108YZN class I peptide chain release factor I635_19050 ENOG4107TTQ Alpha beta hydrolase fold I635_19070 ENOG4105DS1 cytochrome b561 I635_19080 ENOG4105CEP NADH dehydrogenase I635_19095 ENOG4105CR8 Transcriptional regulator I635_19100 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation I635_19105 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein I635_19115 ENOG4105BZU Histidine kinase I635_19125 ENOG4105DEN Luciferase family I635_19130 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) I635_19135 ENOG4105E98 transcriptional regulator DeoR family I635_19140 ENOG4105D9R oxidoreductase I635_19145 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) I635_19155 ENOG4108Q5Y Membrane I635_19160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) I635_19165 ENOG4105D03 DNA-3-methyladenine glycosylase II I635_19170 ENOG41066YJ Beta-lactamase I635_19175 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) I635_19185 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) I635_19190 ENOG4105W8H transhydrogenase (subunit alpha I635_19195 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) I635_19265 ENOG4105KQ5 peptidylprolyl cis-trans isomerase I635_19270 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I635_19275 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) I635_19280 ENOG4105CCU oxidase (Subunit III) I635_19285 ENOG4105BZ9 Cytochrome C oxidase, subunit I I635_19290 ENOG4105E2S oxidase) subunit II I635_19325 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) I635_19330 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) I635_19335 ENOG4105FS0 cytoplasmic membrane protein I635_19340 ENOG4105VF7 tolerance protein I635_19345 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) I635_19350 ENOG4105DR5 peptidase I635_19355 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) I635_19360 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein I635_19365 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase I635_19415 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) I635_19425 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) I635_19430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) I635_19435 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) I635_19440 ENOG4105DC1 bifunctional purine biosynthesis protein purh I635_19450 ENOG4105C12 Phosphoribosylglycinamide synthetase I635_19465 ENOG4105EYW Ion transport protein I635_19470 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) I635_19480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family I635_19490 ENOG4105E0F Histidine kinase I635_19500 ENOG4105CJQ hydrolase, family 31 I635_19510 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase I635_19515 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) I635_19520 ENOG4105VEJ Heat shock protein I635_19525 ENOG4108XKW General secretion pathway protein C I635_19535 ENOG4107QHF type ii secretion system protein e I635_19540 ENOG4105D7Q type ii secretion system I635_19545 ENOG4108VAU general secretion pathway protein G I635_19550 ENOG4105VWV general secretion pathway protein h I635_19590 ENOG4105C26 Dehydrogenase I635_19600 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 I635_19605 ENOG4107RK2 ADP-ribose diphosphatase NudE I635_19620 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) I635_19625 ENOG4105DJ9 glucan biosynthesis protein I635_19635 ENOG4105YP7 UPF0270 protein I635_19640 ENOG4105DNZ Alpha Beta Hydrolase I635_19650 ENOG4105C5H ABC transporter I635_19670 ENOG41069P5 Protein slyX homolog I635_19680 ENOG4108V1T peptidylprolyl cis-trans isomerase I635_19690 ENOG4108RRZ Transcription elongation factor GreB I635_19695 ENOG4105BZM domain protein I635_19700 ENOG4105QV4 Tryptophan halogenase I635_19725 ENOG4105T16 Transcriptional regulator (AraC family) I635_19730 ENOG4105CT4 transporter I635_19735 ENOG4105DT9 hydrolase family 43 I635_19750 ENOG4105CPC Aldo Keto reductase I635_19755 ENOG4105CV1 Transketolase (EC 2.2.1.1) I635_19760 ENOG4105C93 Xylose Isomerase I635_19765 ENOG4105CMG Carbohydrate kinase I635_19770 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) I635_19805 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) I635_19830 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) I635_19835 ENOG4105MJ2 Competence protein I635_19845 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) I635_19865 ENOG4107R73 Mate efflux family protein I635_19880 ENOG4108ZX6 Electron transport protein SCO1 SenC I635_19885 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I635_19890 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) I635_19910 ENOG4107QS1 Cytochrome C Oxidase, Subunit III I635_19915 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) I635_19920 ENOG4105BZ9 Cytochrome C oxidase, subunit I I635_19930 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) I635_19935 ENOG4105E55 glycerol-3-phosphate acyltransferase I635_19940 ENOG4105C7B Threonine dehydratase I635_19945 ENOG4105C01 Dihydroxy-acid dehydratase I635_19950 ENOG4105EN6 Membrane I635_19955 ENOG4105C0P Mg chelatase subunit ChlI I635_19960 ENOG4105EMY transcriptional regulator I635_19965 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase I635_19970 ENOG4105C2C drug resistance transporter, Bcr CflA I635_19980 ENOG4105CFU surface antigen I635_19985 ENOG4105MA0 exported protein I635_20010 ENOG4105C5I Dehydrogenase I635_20020 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) I635_20065 ENOG4105CI2 imidazolone-5-propionate hydrolase I635_20090 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) I635_20095 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) I635_20100 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) I635_20110 ENOG4105DSJ YicC domain protein I635_20200 ENOG410600T transposase I635_20205 ENOG41061MV Arylsulfatase I635_20210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I635_20225 ENOG4107QVM von Willebrand factor, type A I635_20250 ENOG4107RGH Aldehyde dehydrogenase I635_20260 ENOG410846T CoA-transferase family III I635_20270 ENOG4105C1G acyl-Coa dehydrogenase I635_20280 ENOG4105E39 Enoyl-CoA hydratase I635_20285 ENOG4108ZX5 transcriptional regulator I635_20300 ENOG4108UHU Aldolase I635_20305 ENOG4105CHC glucokinase (EC 2.7.1.2) I635_20310 ENOG4105C01 Dihydroxy-acid dehydratase I635_20315 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) I635_20320 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I635_20325 ENOG4106KNT transcriptional regulator I635_20330 ENOG4105CA9 Pyruvate kinase I635_20360 ENOG4107R3N Filamentation induced by cAMP protein fic I635_20370 ENOG41060NJ transcriptional regulator I635_20380 ENOG4105CDV Ompa motb domain protein I635_20385 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase I635_20400 ENOG4108K3A Glutathione S-transferase I635_20410 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) I635_20415 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) I635_20420 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) I635_20425 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) I635_20430 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) I635_20435 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) I635_20440 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) I635_20445 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) I635_20455 ENOG4105FA0 parb-like partition protein I635_20460 ENOG4107QJE Chromosome Partitioning Protein I635_20465 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) I635_20470 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) I635_20475 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) I635_20490 ENOG4105QTB Flavodoxin I635_20495 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) I635_20500 ENOG4108VPT UPF0234 protein I635_20505 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins I635_20510 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) I635_20515 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) I635_20520 ENOG4105VG0 50S ribosomal protein l34 I635_21034 ENOG4105CZX twitching motility protein I635_21234 ENOG4105BZ1 (ABC) transporter I635_21299 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I635_21334 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) I635_21379 ENOG4105DB4 I635_21419 ENOG4105CNA YD repeat protein I635_21429 ENOG4105CNA YD repeat protein I635_21559 ENOG4105FE5 Homospermidine synthase I635_21564 ENOG4105IBP Cyclic peptide transporter I635_21584 ENOG4105WQT MbtH domain protein I635_21754 ENOG4105ENA helicase I635_21794 ENOG4107QHF type ii secretion system protein e I635_21989 ENOG4105BZU Histidine kinase I635_22004 ENOG4105BZU Histidine kinase