locus-tag	class	description
I635_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I635_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I635_00020	COG0187	DNA topoisomerase II activity
I635_00040	COG2818	Glycosylase
I635_00050	COG3078	GTPase activator activity
I635_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I635_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I635_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I635_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I635_00085	COG0569	domain protein
I635_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I635_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I635_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I635_00110	COG0758	DNA mediated transformation
I635_00125	COG0009	L-threonylcarbamoyladenylate synthase
I635_00130	COG0408	coproporphyrinogen oxidase activity
I635_00135	COG3047	cAMP biosynthetic process
I635_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I635_00210	COG2234	aminopeptidase activity
I635_00215	COG0463	Glycosyl transferase, family 2
I635_00225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I635_00250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_00280	COG3642	lipopolysaccharide core region biosynthetic process
I635_00285	COG0859	PFAM glycosyl transferase family 9
I635_00315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_00330	COG3161	chorismate lyase activity
I635_00335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I635_00355	COG0210	DNA helicase
I635_00400	COG1959	2 iron, 2 sulfur cluster binding
I635_00405	COG0730	response to heat
I635_00420	COG4771	TonB-dependent receptor
I635_00435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I635_00440	COG4988	ABC transporter
I635_00450	COG1271	oxidase subunit
I635_00460	COG0425	Belongs to the sulfur carrier protein TusA family
I635_00460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_00470	COG0450	alkyl hydroperoxide reductase
I635_00480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I635_00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I635_00555	COG0270	DNA (cytosine-5-)-methyltransferase activity
I635_00560	COG0556	nucleotide-excision repair
I635_00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_00575	COG1129	ABC transporter
I635_00575	COG0842	Transport permease protein
I635_00580	COG0842	Transport permease protein
I635_00595	COG1960	acyl-CoA dehydrogenase activity
I635_00600	COG0583	DNA-binding transcription factor activity
I635_00610	COG3106	COG3106 Predicted ATPase
I635_00630	COG2184	nucleotidyltransferase activity
I635_00635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I635_00650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I635_00655	COG0352	thiamine-phosphate diphosphorylase activity
I635_00665	COG3071	HemY protein
I635_00670	COG2959	enzyme of heme biosynthesis
I635_00680	COG0181	hydroxymethylbilane synthase activity
I635_00700	COG0194	GDP metabolic process
I635_00710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I635_00720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I635_00725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I635_00735	COG0678	peroxiredoxin activity
I635_00755	COG1178	ABC-type Fe3 transport system permease component
I635_00760	COG3842	ATPase activity
I635_00765	COG0668	transmembrane transport
I635_00770	COG2081	HI0933 family
I635_00790	COG2963	transposase activity
I635_00825	COG0789	Transcriptional regulator
I635_00830	COG2963	transposase activity
I635_00835	COG2801	Transposase and inactivated derivatives
I635_00850	COG2200	EAL domain
I635_00855	COG0583	DNA-binding transcription factor activity
I635_00865	COG2076	Multidrug Resistance protein
I635_00880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_00895	COG0427	acetyl-CoA hydrolase
I635_00900	COG0123	including yeast histone deacetylase and acetoin utilization protein
I635_00915	COG0840	transmembrane signaling receptor activity
I635_00925	COG3064	Membrane
I635_00935	COG5001	Diguanylate cyclase
I635_00935	COG5002	protein histidine kinase activity
I635_00950	COG0514	ATP-dependent DNA helicase (RecQ)
I635_00955	COG2239	Acts as a magnesium transporter
I635_00960	COG2962	Rard protein
I635_00965	COG3706	GGDEF domain
I635_00965	COG0745	RESPONSE REGULATOR receiver
I635_00970	COG0210	DNA helicase
I635_00980	COG1011	Hydrolase
I635_00995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I635_01000	COG0019	diaminopimelate decarboxylase activity
I635_01030	COG0163	prenyltransferase activity
I635_01035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I635_01045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I635_01065	COG1077	Cell shape determining protein MreB Mrl
I635_01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I635_01080	COG2814	Major facilitator Superfamily
I635_01085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_01115	COG1085	galactose-1-phosphate uridylyltransferase
I635_01120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I635_01130	COG0629	single-stranded DNA binding
I635_01145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I635_01150	COG3250	beta-galactosidase activity
I635_01175	COG1349	DNA-binding transcription factor activity
I635_01220	COG3267	Type II secretory pathway component ExeA
I635_01220	COG3409	Peptidoglycan-binding domain 1 protein
I635_01235	COG1459	type II secretion system
I635_01280	COG1077	Cell shape determining protein MreB Mrl
I635_01285	COG1792	Involved in formation and maintenance of cell shape
I635_01290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I635_01300	COG1530	ribonuclease E activity
I635_01310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_01315	COG0312	modulator of DNA gyrase
I635_01320	COG3028	Belongs to the UPF0307 family
I635_01325	COG0312	modulator of DNA gyrase
I635_01335	COG0745	RESPONSE REGULATOR receiver
I635_01340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_01340	COG4191	Histidine kinase
I635_01345	COG0297	glycogen (starch) synthase activity
I635_01355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I635_01360	COG0596	Alpha beta hydrolase
I635_01390	COG5002	protein histidine kinase activity
I635_01395	COG0745	RESPONSE REGULATOR receiver
I635_01420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_01520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I635_01550	COG0375	protein maturation
I635_01560	COG0409	Hydrogenase expression formation protein
I635_01570	COG0309	Hydrogenase expression formation protein (HypE)
I635_01575	COG0789	Transcriptional regulator
I635_01580	COG2217	Heavy metal translocating P-type atpase
I635_01670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I635_01680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I635_01690	COG0463	Glycosyl transferase, family 2
I635_01695	COG0745	RESPONSE REGULATOR receiver
I635_01700	COG5002	protein histidine kinase activity
I635_01735	COG0789	Transcriptional regulator
I635_01740	COG2217	Heavy metal translocating P-type atpase
I635_01780	COG0531	amino acid
I635_01790	COG2132	Multicopper oxidase
I635_01850	COG2801	Transposase and inactivated derivatives
I635_01905	COG0546	phosphoglycolate phosphatase activity
I635_01935	COG1609	Transcriptional regulator
I635_01940	COG0673	inositol 2-dehydrogenase activity
I635_01950	COG2211	Major facilitator Superfamily
I635_01975	COG1454	alcohol dehydrogenase
I635_02025	COG0089	rRNA binding
I635_02035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I635_02045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I635_02060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I635_02065	COG0438	transferase activity, transferring glycosyl groups
I635_02075	COG1519	Transferase
I635_02110	COG0788	formyltetrahydrofolate deformylase activity
I635_02120	COG1643	Atp-dependent helicase
I635_02125	COG2951	lytic endotransglycosylase activity
I635_02130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I635_02145	COG2354	Protein conserved in bacteria
I635_02150	COG4977	sequence-specific DNA binding
I635_02165	COG0004	ammonium transporteR
I635_02170	COG0405	Gamma-glutamyltransferase
I635_02175	COG2837	iron assimilation
I635_02190	COG0540	Belongs to the ATCase OTCase family
I635_02215	COG5002	protein histidine kinase activity
I635_02215	COG2205	protein histidine kinase activity
I635_02215	COG0784	Response regulator, receiver
I635_02230	COG3300	MHYT domain
I635_02230	COG5001	Diguanylate cyclase
I635_02240	COG1012	belongs to the aldehyde dehydrogenase family
I635_02250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I635_02265	COG0180	Tryptophanyl-tRNA synthetase
I635_02270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I635_02290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I635_02300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I635_02335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I635_02340	COG0281	malic enzyme
I635_02355	COG0625	glutathione transferase activity
I635_02365	COG0753	catalase activity
I635_02380	COG3300	MHYT domain
I635_02380	COG5001	Diguanylate cyclase
I635_02385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I635_02385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I635_02395	COG0137	argininosuccinate synthase activity
I635_02415	COG1803	Methylglyoxal synthase
I635_02425	COG0745	RESPONSE REGULATOR receiver
I635_02430	COG2205	protein histidine kinase activity
I635_02435	COG2267	carboxylic ester hydrolase activity
I635_02440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I635_02450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I635_02460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I635_02465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_02470	COG4942	peptidase
I635_02475	COG2861	carbohydrate metabolic process
I635_02500	COG1162	GTPase activity
I635_02505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I635_02530	COG0028	Belongs to the TPP enzyme family
I635_02550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I635_02555	COG0805	protein transport
I635_02565	COG0084	hydrolase, TatD family'
I635_02570	COG2203	Gaf domain
I635_02570	COG5001	Diguanylate cyclase
I635_02570	COG4251	negative regulation of phosphorylation
I635_02570	COG3706	GGDEF domain
I635_02580	COG0248	Ppx GppA phosphatase
I635_02585	COG0513	Belongs to the DEAD box helicase family
I635_02590	COG3118	belongs to the thioredoxin family
I635_02595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I635_02605	COG5002	protein histidine kinase activity
I635_02605	COG0784	Response regulator, receiver
I635_02610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I635_02620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I635_02630	COG0783	Belongs to the Dps family
I635_02635	COG2133	pyrroloquinoline quinone binding
I635_02640	COG1506	peptidase
I635_02640	COG0823	Involved in the tonB-independent uptake of proteins
I635_02640	COG4946	Tricorn protease homolog
I635_02650	COG3118	belongs to the thioredoxin family
I635_02665	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I635_02675	COG1012	belongs to the aldehyde dehydrogenase family
I635_02695	COG1757	Na H antiporter
I635_02710	COG3876	Protein conserved in bacteria
I635_02715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I635_02725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I635_02735	COG0346	lactoylglutathione lyase activity
I635_02760	COG2824	Alkylphosphonate utilization operon protein PhnA
I635_02765	COG0454	-acetyltransferase
I635_02795	COG3093	addiction module antidote protein HigA
I635_02810	COG2026	Addiction module toxin, RelE StbE family
I635_02900	COG0183	Belongs to the thiolase family
I635_02905	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_02905	COG1024	Enoyl-CoA hydratase
I635_02915	COG0006	proline dipeptidase activity
I635_02925	COG0142	geranyltranstransferase activity
I635_02955	COG4942	peptidase
I635_02955	COG1388	LysM domain
I635_02960	COG1238	metal cluster binding
I635_02970	COG0585	pseudouridine synthase activity
I635_02975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I635_02985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I635_02995	COG0840	transmembrane signaling receptor activity
I635_03035	COG0494	nUDIX hydrolase
I635_03040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I635_03045	COG0730	response to heat
I635_03050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I635_03055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I635_03065	COG3706	GGDEF domain
I635_03065	COG0745	RESPONSE REGULATOR receiver
I635_03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I635_03105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I635_03115	COG1648	precorrin-2 dehydrogenase activity
I635_03115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I635_03120	COG0513	Belongs to the DEAD box helicase family
I635_03140	COG1538	Outer membrane efflux protein
I635_03145	COG0494	nUDIX hydrolase
I635_03155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I635_03160	COG3150	esterase
I635_03165	COG0187	DNA topoisomerase II activity
I635_03175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_03200	COG1509	lysine 2,3-aminomutase activity
I635_03210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I635_03225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I635_03240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I635_03255	COG0271	Belongs to the BolA IbaG family
I635_03275	COG3707	response regulator
I635_03285	COG0659	secondary active sulfate transmembrane transporter activity
I635_03290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I635_03300	COG0243	molybdopterin cofactor binding
I635_03305	COG1648	precorrin-2 dehydrogenase activity
I635_03305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I635_03310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I635_03320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I635_03320	COG1116	anion transmembrane transporter activity
I635_03330	COG1116	anion transmembrane transporter activity
I635_03345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_03350	COG4206	TonB-dependent receptor
I635_03360	COG0348	domain, Protein
I635_03375	COG1960	acyl-CoA dehydrogenase activity
I635_03380	COG1028	Short-chain dehydrogenase reductase Sdr
I635_03390	COG4948	Mandelate Racemase Muconate Lactonizing
I635_03405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_03410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_03430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I635_03435	COG0358	DNA primase activity
I635_03465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I635_03470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I635_03485	COG0537	adenosine 5'-monophosphoramidase activity
I635_03500	COG3135	benzoate transporter
I635_03505	COG1396	sequence-specific DNA binding
I635_03510	COG2974	May be involved in recombination
I635_03515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_03515	COG4191	Histidine kinase
I635_03520	COG0745	RESPONSE REGULATOR receiver
I635_03525	COG5002	protein histidine kinase activity
I635_03550	COG0811	peptide transport
I635_03555	COG0811	peptide transport
I635_03560	COG0848	biopolymer transport protein
I635_03565	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I635_03575	COG3437	response regulator, receiver
I635_03585	COG0318	PFAM AMP-dependent synthetase and ligase
I635_03595	COG2133	pyrroloquinoline quinone binding
I635_03605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_03630	COG0527	aspartate kinase activity
I635_03635	COG0840	transmembrane signaling receptor activity
I635_03640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I635_03645	COG2967	ApaG domain
I635_03655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I635_03660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_03665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I635_03670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I635_03680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_03700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I635_03715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I635_03720	COG3956	TIGRFAM MazG family protein
I635_03745	COG1028	Short-chain dehydrogenase reductase Sdr
I635_03755	COG0318	PFAM AMP-dependent synthetase and ligase
I635_03765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I635_03775	COG0463	Glycosyl transferase, family 2
I635_03795	COG0642	Histidine kinase
I635_03800	COG0745	RESPONSE REGULATOR receiver
I635_03815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I635_03820	COG0723	plastoquinol--plastocyanin reductase activity
I635_03825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I635_03830	COG2857	Cytochrome c1
I635_03835	COG0625	glutathione transferase activity
I635_03840	COG2969	positive regulation of protein catabolic process
I635_03845	COG2239	Acts as a magnesium transporter
I635_03850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I635_03860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I635_03870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I635_03875	COG1137	ATPase activity
I635_03880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I635_03890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I635_03905	COG1127	ABC transporter
I635_03910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I635_03915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I635_03920	COG2854	intermembrane phospholipid transfer
I635_03930	COG5007	Belongs to the BolA IbaG family
I635_03940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I635_03945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I635_03955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I635_03990	COG4771	TonB-dependent receptor
I635_03995	COG0697	spore germination
I635_04005	COG2205	protein histidine kinase activity
I635_04005	COG0784	Response regulator, receiver
I635_04030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I635_04040	COG0126	phosphoglycerate kinase activity
I635_04045	COG3588	fructose-bisphosphate aldolase
I635_04055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_04065	COG1538	Outer membrane efflux protein
I635_04070	COG0823	Involved in the tonB-independent uptake of proteins
I635_04070	COG1506	peptidase
I635_04070	COG4946	Tricorn protease homolog
I635_04075	COG0248	Ppx GppA phosphatase
I635_04080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I635_04090	COG0573	inorganic phosphate transmembrane transporter activity
I635_04100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I635_04110	COG0306	phosphate transporter
I635_04120	COG0583	DNA-binding transcription factor activity
I635_04130	COG1272	protein, Hemolysin III
I635_04135	COG1846	Transcriptional regulator
I635_04140	COG1764	response to oxidative stress
I635_04155	COG1739	Uncharacterized protein family UPF0029
I635_04175	COG0420	3'-5' exonuclease activity
I635_04180	COG0419	ATPase involved in DNA repair
I635_04195	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I635_04210	COG2188	Transcriptional regulator
I635_04220	COG2986	histidine ammonia-lyase
I635_04250	COG0488	(ABC) transporter
I635_04275	COG0668	transmembrane transport
I635_04325	COG0582	viral genome integration into host DNA
I635_04330	COG4372	Transposase
I635_04380	COG1484	DNA-dependent DNA replication
I635_04390	COG2801	Transposase and inactivated derivatives
I635_04400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I635_04415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I635_04460	COG1346	cytolysis
I635_04490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I635_04500	COG0513	Belongs to the DEAD box helicase family
I635_04510	COG3267	Type II secretory pathway component ExeA
I635_04510	COG3409	Peptidoglycan-binding domain 1 protein
I635_04525	COG0066	3-isopropylmalate dehydratase activity
I635_04535	COG0473	3-isopropylmalate dehydrogenase activity
I635_04540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I635_04560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I635_04575	COG4555	ABC transporter
I635_04580	COG1668	transmembrane transport
I635_04600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_04605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_04610	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I635_04620	COG1138	Cytochrome C-type biogenesis protein
I635_04625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I635_04640	COG2853	Lipoprotein
I635_04645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I635_04655	COG3104	oligopeptide transport
I635_04685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I635_04700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I635_04705	COG1555	photosystem II stabilization
I635_04705	COG1596	polysaccharide export
I635_04710	COG0473	3-isopropylmalate dehydrogenase activity
I635_04725	COG1611	Belongs to the LOG family
I635_04730	COG3706	GGDEF domain
I635_04730	COG0745	RESPONSE REGULATOR receiver
I635_04735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I635_04735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I635_04790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I635_04795	COG0024	Methionine aminopeptidase
I635_04800	COG0052	Belongs to the universal ribosomal protein uS2 family
I635_04810	COG0528	UMP kinase activity
I635_04820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I635_04825	COG0575	Belongs to the CDS family
I635_04850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I635_04870	COG0587	DNA-directed DNA polymerase activity
I635_04875	COG0825	malonyl-CoA metabolic process
I635_04880	COG0037	tRNA processing
I635_04900	COG0590	tRNA wobble adenosine to inosine editing
I635_04915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I635_04915	COG0047	phosphoribosylformylglycinamidine synthase activity
I635_04925	COG2840	Smr protein MutS2
I635_04965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_04970	COG2197	response regulator
I635_05010	COG0784	Response regulator, receiver
I635_05010	COG0835	chemotaxis
I635_05015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I635_05020	COG1815	bacterial-type flagellum-dependent cell motility
I635_05025	COG1558	bacterial-type flagellum-dependent cell motility
I635_05030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I635_05035	COG1749	Flagellar hook protein flgE
I635_05040	COG4787	bacterial-type flagellum-dependent cell motility
I635_05045	COG4786	Flagellar basal body rod
I635_05060	COG1705	Flagellar rod assembly protein muramidase FlgJ
I635_05060	COG3951	Flagellar rod assembly protein muramidase FlgJ
I635_05065	COG1256	bacterial-type flagellum assembly
I635_05080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_05085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_05090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_05095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I635_05110	COG1516	flagellar protein fliS
I635_05125	COG1086	Polysaccharide biosynthesis protein
I635_05130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I635_05140	COG2089	acid synthase
I635_05155	COG1028	Short-chain dehydrogenase reductase Sdr
I635_05160	COG0318	PFAM AMP-dependent synthetase and ligase
I635_05205	COG1660	Displays ATPase and GTPase activities
I635_05210	COG1216	Glycosyl transferase, family 2
I635_05225	COG1083	cytidylyl-transferase
I635_05235	COG2204	response regulator
I635_05240	COG3852	Histidine kinase
I635_05245	COG2204	response regulator
I635_05250	COG1677	Flagellar hook-basal body complex protein FliE
I635_05255	COG1766	The M ring may be actively involved in energy transduction
I635_05260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I635_05310	COG1987	bacterial-type flagellum assembly
I635_05325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I635_05335	COG0455	bacterial-type flagellum organization
I635_05350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I635_05355	COG2198	Histidine kinase
I635_05355	COG0643	Histidine kinase
I635_05365	COG1192	Involved in chromosome partitioning
I635_05375	COG0835	chemotaxis
I635_05390	COG0646	methionine synthase
I635_05390	COG1410	methionine synthase
I635_05395	COG1410	methionine synthase
I635_05395	COG0646	methionine synthase
I635_05405	COG3123	guanosine phosphorylase activity
I635_05410	COG0583	DNA-binding transcription factor activity
I635_05415	COG0583	DNA-binding transcription factor activity
I635_05425	COG0659	secondary active sulfate transmembrane transporter activity
I635_05440	COG3590	peptidase
I635_05450	COG2137	regulation of response to DNA damage stimulus
I635_05455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I635_05470	COG0511	ligase activity, forming carbon-carbon bonds
I635_05470	COG5016	pyruvate
I635_05475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I635_05480	COG4172	Belongs to the ABC transporter superfamily
I635_05490	COG4171	peptide transport system, permease
I635_05495	COG4168	peptide transport system, permease
I635_05500	COG0747	negative chemotaxis
I635_05505	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I635_05510	COG1842	Phage shock protein A
I635_05540	COG0625	glutathione transferase activity
I635_05545	COG1522	sequence-specific DNA binding
I635_05615	COG0811	peptide transport
I635_05620	COG0811	peptide transport
I635_05625	COG0848	biopolymer transport protein
I635_05640	COG1444	tRNA N-acetyltransferase activity
I635_05675	COG0456	acetyltransferase
I635_05690	COG0583	DNA-binding transcription factor activity
I635_05695	COG2814	Major facilitator Superfamily
I635_05700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_05705	COG0656	L-ascorbic acid biosynthetic process
I635_05725	COG1846	Transcriptional regulator
I635_05740	COG3620	sequence-specific DNA binding
I635_05745	COG3550	peptidyl-serine autophosphorylation
I635_05775	COG0668	transmembrane transport
I635_05785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I635_05805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I635_05930	COG0789	Transcriptional regulator
I635_05950	COG0789	Transcriptional regulator
I635_05955	COG0640	Transcriptional regulator
I635_05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_05965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_05965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_05970	COG1230	cation diffusion facilitator family transporter
I635_06000	COG1538	Outer membrane efflux protein
I635_06040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I635_06055	COG0681	Belongs to the peptidase S26 family
I635_06075	COG1074	ATP-dependent DNA helicase activity
I635_06085	COG1404	Belongs to the peptidase S8 family
I635_06090	COG0464	growth
I635_06110	COG0629	single-stranded DNA binding
I635_06130	COG0714	Associated with various cellular activities
I635_06155	COG2003	Belongs to the UPF0758 family
I635_06175	COG0583	DNA-binding transcription factor activity
I635_06265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I635_06275	COG3706	GGDEF domain
I635_06310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I635_06315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I635_06320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I635_06325	COG0564	pseudouridine synthase activity
I635_06335	COG0612	Peptidase, M16
I635_06340	COG2918	glutathione biosynthetic process
I635_06365	COG2840	Smr protein MutS2
I635_06370	COG2890	protein-(glutamine-N5) methyltransferase activity
I635_06385	COG2719	SpoVR family
I635_06390	COG2718	Belongs to the UPF0229 family
I635_06395	COG2766	serine protein kinase
I635_06405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I635_06410	COG4771	TonB-dependent receptor
I635_06435	COG0450	alkyl hydroperoxide reductase
I635_06440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I635_06445	COG2885	chlorophyll binding
I635_06450	COG0584	glycerophosphoryl diester phosphodiesterase
I635_06455	COG0346	lactoylglutathione lyase activity
I635_06460	COG1278	Cold shock
I635_06475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I635_06480	COG4660	Part of a membrane complex involved in electron transport
I635_06485	COG4659	FMN binding
I635_06490	COG4658	electron transport chain
I635_06495	COG4656	Part of a membrane complex involved in electron transport
I635_06500	COG2878	Part of a membrane complex involved in electron transport
I635_06510	COG0534	Mate efflux family protein
I635_06515	COG0556	nucleotide-excision repair
I635_06530	COG0602	queuosine metabolic process
I635_06540	COG0367	asparagine synthase
I635_06565	COG0471	metal ion transport
I635_06565	COG3273	potassium ion transport
I635_06580	COG0529	Catalyzes the synthesis of activated sulfate
I635_06585	COG0175	sulfate reduction
I635_06590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_06595	COG3706	GGDEF domain
I635_06620	COG2304	oxidoreductase activity
I635_06640	COG0714	Associated with various cellular activities
I635_06650	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_06650	COG1024	Enoyl-CoA hydratase
I635_06670	COG1025	Belongs to the peptidase M16 family
I635_06675	COG2062	phosphohistidine phosphatase, SixA
I635_06685	COG4536	flavin adenine dinucleotide binding
I635_06690	COG4137	Cytochrome C assembly protein
I635_06695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I635_06740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_06745	COG1132	(ABC) transporter
I635_06760	COG0228	four-way junction DNA binding
I635_06765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I635_06770	COG0336	Belongs to the RNA methyltransferase TrmD family
I635_06775	COG0335	large ribosomal subunit rRNA binding
I635_06780	COG2860	membrane
I635_06790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I635_06795	COG1605	Chorismate mutase
I635_06795	COG0287	Prephenate dehydrogenase
I635_06800	COG0077	Prephenate dehydratase
I635_06800	COG1605	Chorismate mutase
I635_06810	COG0023	Translation Initiation Factor
I635_06840	COG2205	protein histidine kinase activity
I635_06850	COG2204	response regulator
I635_06875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I635_06880	COG0494	nUDIX hydrolase
I635_06885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I635_06895	COG2255	four-way junction helicase activity
I635_06900	COG0824	Thioesterase
I635_06905	COG0811	peptide transport
I635_06920	COG0823	Involved in the tonB-independent uptake of proteins
I635_06925	COG2885	chlorophyll binding
I635_06930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I635_06940	COG3344	reverse transcriptase
I635_06950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I635_06965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I635_06980	COG4667	esterase of the alpha-beta hydrolase superfamily
I635_06985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I635_06995	COG2205	protein histidine kinase activity
I635_06995	COG0784	Response regulator, receiver
I635_07015	COG3038	cytochrome b561
I635_07035	COG0583	DNA-binding transcription factor activity
I635_07040	COG1451	nucleotide metabolic process
I635_07050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_07060	COG1309	transcriptional regulator
I635_07065	COG4774	siderophore transport
I635_07085	COG3706	GGDEF domain
I635_07095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I635_07095	COG3008	intermembrane lipid transfer
I635_07100	COG2995	paraquat-inducible protein a
I635_07115	COG0017	Asparaginyl-tRNA synthetase
I635_07130	COG0189	ligase activity
I635_07160	COG0156	8-amino-7-oxononanoate synthase activity
I635_07165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_07175	COG3340	Belongs to the peptidase S51 family
I635_07180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I635_07185	COG4139	cobalamin transport
I635_07190	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I635_07195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I635_07210	COG5265	(ABC) transporter
I635_07215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I635_07225	COG0745	RESPONSE REGULATOR receiver
I635_07230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I635_07250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_07265	COG2755	lipolytic protein G-D-S-L family
I635_07270	COG4181	ATPase activity
I635_07275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I635_07280	COG1090	epimerase
I635_07285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I635_07290	COG0628	permease
I635_07300	COG0745	RESPONSE REGULATOR receiver
I635_07315	COG2350	Protein conserved in bacteria
I635_07320	COG0159	tryptophan synthase activity
I635_07330	COG0135	phosphoribosylanthranilate isomerase activity
I635_07330	COG0134	indole-3-glycerol-phosphate synthase activity
I635_07335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I635_07345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I635_07350	COG0613	PHP domain protein
I635_07355	COG0009	L-threonylcarbamoyladenylate synthase
I635_07360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I635_07365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I635_07375	COG0656	L-ascorbic acid biosynthetic process
I635_07380	COG0110	maltose O-acetyltransferase activity
I635_07390	COG2733	membrane
I635_07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_07415	COG0500	methyltransferase
I635_07420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_07425	COG0497	DNA recombination
I635_07430	COG0783	Belongs to the Dps family
I635_07440	COG1454	alcohol dehydrogenase
I635_07445	COG1028	Short-chain dehydrogenase reductase Sdr
I635_07455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I635_07460	COG2610	gluconate transmembrane transporter activity
I635_07465	COG4771	TonB-dependent receptor
I635_07475	COG2205	protein histidine kinase activity
I635_07475	COG2198	Histidine kinase
I635_07475	COG0784	Response regulator, receiver
I635_07480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I635_07490	COG0484	heat shock protein binding
I635_07495	COG3909	cytochrome
I635_07500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I635_07515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I635_07520	COG0505	Belongs to the CarA family
I635_07525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I635_07530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_07550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I635_07555	COG0857	belongs to the CobB CobQ family
I635_07555	COG0280	phosphate acetyltransferase
I635_07570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I635_07575	COG4535	Mg2 and Co2 transporter CorC
I635_07585	COG1702	phosphate starvation-inducible protein PhoH
I635_07595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_07640	COG1607	acyl-coa hydrolase
I635_07645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I635_07655	COG1115	amino acid carrier protein
I635_07665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I635_07670	COG0012	GTP binding
I635_07690	COG1064	alcohol dehydrogenase
I635_07705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I635_07710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I635_07715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I635_07720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I635_07730	COG2890	protein-(glutamine-N5) methyltransferase activity
I635_07735	COG3437	response regulator, receiver
I635_07735	COG0784	Response regulator, receiver
I635_07740	COG3094	Invasion gene expression up-regulator, SirB
I635_07755	COG0583	DNA-binding transcription factor activity
I635_07765	COG2363	Small membrane protein
I635_07780	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I635_07785	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I635_07790	COG0515	serine threonine protein kinase
I635_07795	COG2116	formate transmembrane transporter activity
I635_07810	COG0714	Associated with various cellular activities
I635_07815	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I635_07820	COG0033	Phosphoglucomutase
I635_07825	COG0058	SHG alpha-glucan phosphorylase activity
I635_07835	COG2988	succinylglutamate desuccinylase activity
I635_07870	COG1393	Belongs to the ArsC family
I635_07895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I635_07925	COG5001	Diguanylate cyclase
I635_07925	COG3300	MHYT domain
I635_07950	COG2249	NAD(P)H dehydrogenase (quinone) activity
I635_07970	COG1733	regulation of RNA biosynthetic process
I635_07975	COG5002	protein histidine kinase activity
I635_07975	COG5001	Diguanylate cyclase
I635_07975	COG3447	MASE1 domain protein
I635_07985	COG0402	S-adenosylhomocysteine deaminase activity
I635_07990	COG2351	hydroxyisourate hydrolase activity
I635_08005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_08020	COG1309	transcriptional regulator
I635_08035	COG2252	PERMEase
I635_08040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I635_08055	COG2203	Gaf domain
I635_08055	COG3706	GGDEF domain
I635_08055	COG4251	negative regulation of phosphorylation
I635_08055	COG5001	Diguanylate cyclase
I635_08060	COG5001	Diguanylate cyclase
I635_08060	COG3706	GGDEF domain
I635_08060	COG4251	negative regulation of phosphorylation
I635_08060	COG2203	Gaf domain
I635_08065	COG0784	Response regulator, receiver
I635_08065	COG2205	protein histidine kinase activity
I635_08080	COG2233	PERMEase
I635_08095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I635_08100	COG0730	response to heat
I635_08145	COG1028	Short-chain dehydrogenase reductase Sdr
I635_08160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I635_08175	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I635_08175	COG0662	Cupin 2, conserved barrel domain protein
I635_08180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I635_08190	COG1596	polysaccharide export
I635_08195	COG0489	protein tyrosine kinase activity
I635_08200	COG4464	protein tyrosine phosphatase activity
I635_08255	COG1216	Glycosyl transferase, family 2
I635_08270	COG1215	transferase activity, transferring glycosyl groups
I635_08275	COG0438	transferase activity, transferring glycosyl groups
I635_08285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I635_08305	COG0072	phenylalanine-tRNA ligase activity
I635_08305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_08320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I635_08330	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_08335	COG2096	Adenosyltransferase
I635_08345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I635_08355	COG4591	ABC-type transport system involved in lipoprotein release permease component
I635_08380	COG0708	Exodeoxyribonuclease III
I635_08415	COG2814	Major facilitator Superfamily
I635_08460	COG1024	Enoyl-CoA hydratase
I635_08465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I635_08470	COG1960	acyl-CoA dehydrogenase activity
I635_08475	COG0789	Transcriptional regulator
I635_08480	COG0183	Belongs to the thiolase family
I635_08495	COG3706	GGDEF domain
I635_08505	COG2925	Exonuclease
I635_08510	COG0582	viral genome integration into host DNA
I635_08550	COG1674	ftsk spoiiie
I635_08550	COG0531	amino acid
I635_08595	COG2197	response regulator
I635_08610	COG3617	BRO family, N-terminal domain
I635_08680	COG0305	Participates in initiation and elongation during chromosome replication
I635_08770	COG5484	DNA packaging
I635_08770	COG3728	DNA packaging
I635_08920	COG1643	Atp-dependent helicase
I635_08940	COG3321	synthase
I635_08940	COG0604	alcohol dehydrogenase
I635_08945	COG0328	RNA-DNA hybrid ribonuclease activity
I635_08950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I635_08960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I635_08970	COG4591	ABC-type transport system involved in lipoprotein release permease component
I635_08985	COG3724	N-succinylarginine dihydrolase activity
I635_08995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I635_09010	COG0746	molybdenum cofactor guanylyltransferase activity
I635_09015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I635_09020	COG0243	molybdopterin cofactor binding
I635_09025	COG2153	protein acetylation
I635_09040	COG1530	ribonuclease E activity
I635_09055	COG0424	maF-like protein
I635_09060	COG1399	metal-binding, possibly nucleic acid-binding protein
I635_09070	COG0416	fatty acid biosynthetic process
I635_09075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I635_09080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I635_09090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I635_09095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I635_09105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I635_09120	COG0084	hydrolase, TatD family'
I635_09130	COG0702	epimerase
I635_09135	COG3706	GGDEF domain
I635_09135	COG0745	RESPONSE REGULATOR receiver
I635_09155	COG1028	Short-chain dehydrogenase reductase Sdr
I635_09160	COG0596	Alpha beta hydrolase
I635_09170	COG0183	Belongs to the thiolase family
I635_09175	COG1960	acyl-CoA dehydrogenase activity
I635_09195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I635_09205	COG0246	Mannitol dehydrogenase
I635_09230	COG0668	transmembrane transport
I635_09235	COG4771	TonB-dependent receptor
I635_09250	COG3437	response regulator, receiver
I635_09260	COG0195	Participates in both transcription termination and antitermination
I635_09275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I635_09290	COG1187	pseudouridine synthase activity
I635_09300	COG3153	acetyltransferase
I635_09300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_09340	COG0450	alkyl hydroperoxide reductase
I635_09385	COG1032	radical SAM domain protein
I635_09400	COG4771	TonB-dependent receptor
I635_09405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_09415	COG4134	Bacterial extracellular solute-binding protein
I635_09425	COG4136	ATPase activity
I635_09430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I635_09455	COG4251	negative regulation of phosphorylation
I635_09455	COG2203	Gaf domain
I635_09455	COG5001	Diguanylate cyclase
I635_09455	COG3706	GGDEF domain
I635_09490	COG4372	Transposase
I635_09500	COG1902	pentaerythritol trinitrate reductase activity
I635_09510	COG2867	negative regulation of translational initiation
I635_09515	COG2914	Belongs to the UPF0125 (RnfH) family
I635_09535	COG4771	TonB-dependent receptor
I635_09545	COG0457	Tetratricopeptide repeat
I635_09560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I635_09560	COG0574	Belongs to the PEP-utilizing enzyme family
I635_09600	COG2850	peptidyl-arginine hydroxylation
I635_09610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I635_09615	COG2915	High frequency lysogenization protein hflD homolog
I635_09620	COG0482	sulfurtransferase activity
I635_09625	COG1187	pseudouridine synthase activity
I635_09635	COG1278	Cold shock
I635_09640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I635_09645	COG0542	response to heat
I635_09650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I635_09655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I635_09660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I635_09665	COG0492	ferredoxin-NADP+ reductase activity
I635_09670	COG3092	negative regulation of chromosome organization
I635_09675	COG3091	SprT-like family
I635_09680	COG0616	signal peptide processing
I635_09695	COG0778	Nitroreductase
I635_09705	COG0252	asparaginase activity
I635_09710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I635_09715	COG0321	lipoyl(octanoyl) transferase activity
I635_09720	COG2921	Belongs to the UPF0250 family
I635_09725	COG1686	Belongs to the peptidase S11 family
I635_09730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I635_09735	COG0772	Belongs to the SEDS family
I635_09740	COG0768	penicillin binding
I635_09745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I635_09750	COG0799	negative regulation of ribosome biogenesis
I635_09760	COG1466	dna polymerase III delta subunit
I635_09765	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I635_09770	COG0495	leucyl-tRNA aminoacylation
I635_09785	COG1067	ATP-dependent peptidase activity
I635_09790	COG0596	Alpha beta hydrolase
I635_09795	COG3706	GGDEF domain
I635_09805	COG1534	Rna-binding protein
I635_09810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I635_09815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I635_09820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I635_09825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I635_09830	COG0149	triose-phosphate isomerase activity
I635_09835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I635_09840	COG3300	MHYT domain
I635_09840	COG5001	Diguanylate cyclase
I635_09860	COG1803	Methylglyoxal synthase
I635_09860	COG1597	lipid kinase activity
I635_09870	COG1028	Short-chain dehydrogenase reductase Sdr
I635_09875	COG0561	phosphatase activity
I635_09890	COG2801	Transposase and inactivated derivatives
I635_09905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_09930	COG1185	polyribonucleotide nucleotidyltransferase activity
I635_09960	COG1819	glycosyl
I635_10000	COG3547	Transposase (IS116 IS110 IS902 family)
I635_10050	COG2801	Transposase and inactivated derivatives
I635_10135	COG4372	Transposase
I635_10170	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I635_10175	COG1196	nuclear chromosome segregation
I635_10185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I635_10205	COG1132	(ABC) transporter
I635_10210	COG1663	tetraacyldisaccharide 4'-kinase activity
I635_10245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I635_10250	COG0435	Glutathione S-transferase
I635_10255	COG1741	Belongs to the pirin family
I635_10260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I635_10270	COG0372	Belongs to the citrate synthase family
I635_10275	COG2009	succinate dehydrogenase
I635_10280	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I635_10285	COG1053	succinate dehydrogenase
I635_10290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I635_10295	COG0567	Dehydrogenase, E1 component
I635_10300	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_10335	COG4667	esterase of the alpha-beta hydrolase superfamily
I635_10355	COG0366	Alpha amylase catalytic
I635_10380	COG1028	Short-chain dehydrogenase reductase Sdr
I635_10385	COG2267	carboxylic ester hydrolase activity
I635_10395	COG0616	signal peptide processing
I635_10415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_10420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I635_10425	COG0386	Belongs to the glutathione peroxidase family
I635_10430	COG2084	Dehydrogenase
I635_10440	COG1960	acyl-CoA dehydrogenase activity
I635_10445	COG1024	Enoyl-CoA hydratase
I635_10455	COG2226	methyltransferase
I635_10460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I635_10465	COG3083	sulfuric ester hydrolase activity
I635_10470	COG3082	Protein of unknown function (DUF1414)
I635_10475	COG3081	Nucleoid-associated protein
I635_10505	COG3275	phosphorelay sensor kinase activity
I635_10510	COG3279	Response regulator of the LytR AlgR family
I635_10515	COG0205	6-phosphofructokinase activity
I635_10530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_10545	COG2205	protein histidine kinase activity
I635_10545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_10565	COG0513	Belongs to the DEAD box helicase family
I635_10575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I635_10580	COG0583	DNA-binding transcription factor activity
I635_10600	COG1760	l-serine dehydratase
I635_10625	COG1322	Protein conserved in bacteria
I635_10630	COG1404	Belongs to the peptidase S8 family
I635_10635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I635_10640	COG0022	dehydrogenase e1 component
I635_10650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I635_10655	COG0515	serine threonine protein kinase
I635_10660	COG1946	Acyl-CoA thioesterase
I635_10670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I635_10680	COG1956	GAF domain-containing protein
I635_10695	COG0793	Belongs to the peptidase S41A family
I635_10700	COG0733	neurotransmitter:sodium symporter activity
I635_10710	COG0308	aminopeptidase N
I635_10740	COG2902	Dehydrogenase
I635_10745	COG0167	dihydroorotate dehydrogenase activity
I635_10770	COG3130	regulation of translation
I635_10775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I635_10785	COG0415	Belongs to the DNA photolyase family
I635_10790	COG0415	Belongs to the DNA photolyase family
I635_10795	COG0415	Belongs to the DNA photolyase family
I635_10800	COG3046	protein related to deoxyribodipyrimidine photolyase
I635_10815	COG4974	Belongs to the 'phage' integrase family
I635_10825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I635_10830	COG0589	response to stress
I635_10840	COG0069	glutamate synthase activity
I635_10855	COG2193	ferroxidase activity
I635_10865	COG3278	Belongs to the heme-copper respiratory oxidase family
I635_10880	COG2010	Cytochrome c
I635_10905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I635_10910	COG0589	response to stress
I635_10915	COG0037	tRNA processing
I635_10920	COG1752	Esterase of the alpha-beta hydrolase superfamily
I635_10940	COG1280	lysine exporter protein (LysE YggA)
I635_10945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I635_10950	COG2897	thiosulfate sulfurtransferase activity
I635_10955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I635_10970	COG0322	excinuclease ABC activity
I635_10975	COG2197	response regulator
I635_10980	COG0436	Aminotransferase
I635_10995	COG2259	Doxx family
I635_11000	COG0583	DNA-binding transcription factor activity
I635_11015	COG0670	Belongs to the BI1 family
I635_11020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I635_11035	COG2920	part of a sulfur-relay system
I635_11065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I635_11075	COG1674	ftsk spoiiie
I635_11075	COG0531	amino acid
I635_11085	COG0686	Belongs to the AlaDH PNT family
I635_11090	COG0284	orotidine-5'-phosphate decarboxylase activity
I635_11095	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I635_11110	COG0776	regulation of translation
I635_11115	COG0539	negative regulation of cytoplasmic translation
I635_11120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I635_11125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I635_11130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I635_11140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I635_11145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I635_11150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I635_11155	COG0633	Ferredoxin
I635_11185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I635_11190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I635_11200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I635_11210	COG4783	chaperone-mediated protein folding
I635_11220	COG1393	Belongs to the ArsC family
I635_11235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I635_11250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I635_11260	COG1960	acyl-CoA dehydrogenase activity
I635_11285	COG0572	uridine kinase
I635_11290	COG3769	mannosylglycerate metabolic process
I635_11295	COG1215	transferase activity, transferring glycosyl groups
I635_11300	COG0366	Alpha amylase catalytic
I635_11310	COG0303	'Molybdopterin
I635_11315	COG0534	Mate efflux family protein
I635_11330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I635_11335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I635_11365	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I635_11385	COG3547	Transposase (IS116 IS110 IS902 family)
I635_11410	COG0405	Gamma-glutamyltransferase
I635_11415	COG1024	Enoyl-CoA hydratase
I635_11460	COG1448	Aminotransferase
I635_11470	COG1671	Belongs to the UPF0178 family
I635_11475	COG1028	Short-chain dehydrogenase reductase Sdr
I635_11480	COG1028	Short-chain dehydrogenase reductase Sdr
I635_11485	COG1960	acyl-CoA dehydrogenase activity
I635_11490	COG0662	Cupin 2, conserved barrel domain protein
I635_11490	COG2207	Transcriptional regulator
I635_11505	COG3344	reverse transcriptase
I635_11510	COG1505	serine-type exopeptidase activity
I635_11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_11550	COG0596	Alpha beta hydrolase
I635_11560	COG0716	FMN binding
I635_11570	COG0735	belongs to the Fur family
I635_11580	COG1984	allophanate hydrolase subunit 2
I635_11585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I635_11590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I635_11595	COG2996	Protein conserved in bacteria
I635_11600	COG1765	OsmC-like protein
I635_11605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_11615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I635_11630	COG0436	Aminotransferase
I635_11635	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_11640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_11650	COG2010	Cytochrome c
I635_11650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_11655	COG2080	2 iron, 2 sulfur cluster binding
I635_11680	COG1073	alpha beta
I635_11685	COG2207	Transcriptional regulator
I635_11695	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_11700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I635_11725	COG3012	SEC-C Motif Domain Protein
I635_11730	COG0604	alcohol dehydrogenase
I635_11740	COG1960	acyl-CoA dehydrogenase activity
I635_11750	COG4771	TonB-dependent receptor
I635_11770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I635_11775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I635_11795	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I635_11800	COG0315	cyclic pyranopterin monophosphate synthase activity
I635_11805	COG0521	Mo-molybdopterin cofactor biosynthetic process
I635_11820	COG2161	toxin-antitoxin pair type II binding
I635_11825	COG4115	mRNA cleavage
I635_11840	COG0436	Aminotransferase
I635_11845	COG3268	Saccharopine dehydrogenase
I635_11850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I635_11865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I635_11870	COG4206	TonB-dependent receptor
I635_11880	COG5006	permease, DMT superfamily
I635_11895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I635_11900	COG1074	ATP-dependent DNA helicase activity
I635_11905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I635_11925	COG1022	Amp-dependent synthetase and ligase
I635_11930	COG5001	Diguanylate cyclase
I635_11930	COG4251	negative regulation of phosphorylation
I635_11930	COG3706	GGDEF domain
I635_11930	COG2203	Gaf domain
I635_11950	COG0583	DNA-binding transcription factor activity
I635_11970	COG0640	Transcriptional regulator
I635_11990	COG2204	response regulator
I635_12000	COG4251	negative regulation of phosphorylation
I635_12005	COG0784	Response regulator, receiver
I635_12010	COG0784	Response regulator, receiver
I635_12010	COG2205	protein histidine kinase activity
I635_12035	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I635_12060	COG3139	Protein of unknown function (DUF1315)
I635_12075	COG1115	amino acid carrier protein
I635_12080	COG2866	Carboxypeptidase
I635_12100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I635_12110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I635_12115	COG1640	4-alpha-glucanotransferase
I635_12120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I635_12125	COG0676	glucose-6-phosphate 1-epimerase activity
I635_12130	COG0800	Aldolase
I635_12140	COG0129	dihydroxy-acid dehydratase activity
I635_12150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_12155	COG1737	Transcriptional regulator
I635_12160	COG0469	pyruvate kinase activity
I635_12175	COG1960	acyl-CoA dehydrogenase activity
I635_12195	COG0490	domain, Protein
I635_12195	COG0471	metal ion transport
I635_12205	COG0800	Aldolase
I635_12215	COG0129	dihydroxy-acid dehydratase activity
I635_12225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_12230	COG1737	Transcriptional regulator
I635_12235	COG0469	pyruvate kinase activity
I635_12240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_12260	COG2823	Periplasmic or secreted lipoprotein
I635_12290	COG3665	Urea carboxylase-associated protein
I635_12330	COG2356	endonuclease I
I635_12350	COG0583	DNA-binding transcription factor activity
I635_12355	COG1979	alcohol dehydrogenase
I635_12370	COG0784	Response regulator, receiver
I635_12370	COG3437	response regulator, receiver
I635_12375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_12375	COG4191	Histidine kinase
I635_12465	COG0471	metal ion transport
I635_12475	COG0489	protein tyrosine kinase activity
I635_12480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_12480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I635_12485	COG0668	transmembrane transport
I635_12490	COG2226	methyltransferase
I635_12495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_12500	COG1388	LysM domain
I635_12500	COG0741	lytic transglycosylase activity
I635_12525	COG0215	cysteine-tRNA ligase activity
I635_12530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I635_12535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I635_12545	COG2268	Band 7 protein
I635_12560	COG1733	regulation of RNA biosynthetic process
I635_12565	COG0604	alcohol dehydrogenase
I635_12570	COG0753	catalase activity
I635_12575	COG0604	alcohol dehydrogenase
I635_12580	COG0583	DNA-binding transcription factor activity
I635_12615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I635_12620	COG1286	toxin biosynthetic process
I635_12625	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I635_12630	COG0285	dihydrofolate synthase activity
I635_12650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I635_12655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I635_12675	COG3609	addiction module antidote protein, CC2985 family
I635_12685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I635_12690	COG0318	PFAM AMP-dependent synthetase and ligase
I635_12700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I635_12700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I635_12735	COG0789	Transcriptional regulator
I635_12740	COG0604	alcohol dehydrogenase
I635_12765	COG1028	Short-chain dehydrogenase reductase Sdr
I635_12770	COG1119	ATPase activity
I635_12775	COG2031	fatty acid transporter
I635_12780	COG0784	Response regulator, receiver
I635_12780	COG5002	protein histidine kinase activity
I635_12780	COG2205	protein histidine kinase activity
I635_12790	COG0612	Peptidase, M16
I635_12805	COG3101	peptidyl-lysine hydroxylation
I635_12835	COG1902	pentaerythritol trinitrate reductase activity
I635_12835	COG0446	pyridine nucleotide-disulphide oxidoreductase
I635_12860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I635_12870	COG4399	Belongs to the UPF0754 family
I635_12895	COG1770	oligopeptidase
I635_12900	COG2186	Transcriptional regulator
I635_12910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I635_12915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I635_12925	COG2983	Belongs to the UPF0260 family
I635_12930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I635_12945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I635_12950	COG0318	PFAM AMP-dependent synthetase and ligase
I635_12955	COG2267	carboxylic ester hydrolase activity
I635_12970	COG1214	PFAM Peptidase M22, glycoprotease
I635_12975	COG1199	ATP-dependent helicase activity
I635_13025	COG4771	TonB-dependent receptor
I635_13035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I635_13040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I635_13045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I635_13050	COG0131	Imidazoleglycerol-phosphate dehydratase
I635_13050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I635_13055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I635_13070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I635_13070	COG0140	phosphoribosyl-ATP diphosphatase activity
I635_13085	COG2116	formate transmembrane transporter activity
I635_13090	COG0612	Peptidase, M16
I635_13125	COG0326	Molecular chaperone. Has ATPase activity
I635_13130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I635_13150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I635_13155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I635_13165	COG3220	belongs to the UPF0276 family
I635_13175	COG0577	efflux transmembrane transporter activity
I635_13175	COG1136	(ABC) transporter
I635_13185	COG4251	negative regulation of phosphorylation
I635_13185	COG2203	Gaf domain
I635_13185	COG5001	Diguanylate cyclase
I635_13185	COG3706	GGDEF domain
I635_13190	COG1183	phosphatidylcholine synthase activity
I635_13210	COG0277	FAD linked oxidase domain protein
I635_13215	COG0542	response to heat
I635_13225	COG0564	pseudouridine synthase activity
I635_13240	COG1595	DNA-templated transcription, initiation
I635_13255	COG4221	oxidoreductase activity
I635_13270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I635_13280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I635_13290	COG0142	geranyltranstransferase activity
I635_13300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I635_13305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I635_13315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I635_13330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I635_13330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I635_13350	COG0488	(ABC) transporter
I635_13360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I635_13370	COG0560	Phosphoserine phosphatase
I635_13380	COG0084	hydrolase, TatD family'
I635_13395	COG0571	ribonuclease III activity
I635_13400	COG0681	Belongs to the peptidase S26 family
I635_13425	COG1595	DNA-templated transcription, initiation
I635_13430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I635_13445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I635_13525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I635_13530	COG1047	Peptidyl-prolyl cis-trans
I635_13540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I635_13545	COG0196	riboflavin kinase activity
I635_13550	COG0728	peptidoglycan biosynthetic process
I635_13555	COG0268	Binds directly to 16S ribosomal RNA
I635_13575	COG0385	Bile acid
I635_13605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_13610	COG0776	regulation of translation
I635_13620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I635_13625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I635_13630	COG0740	serine-type endopeptidase activity
I635_13635	COG0544	peptidyl-prolyl cis-trans isomerase activity
I635_13650	COG1720	tRNA m6t6A37 methyltransferase activity
I635_13660	COG1234	tRNA 3'-trailer cleavage
I635_13670	COG0123	including yeast histone deacetylase and acetoin utilization protein
I635_13685	COG0516	GMP reductase activity
I635_13685	COG0517	IMP dehydrogenase activity
I635_13690	COG1570	exodeoxyribonuclease VII activity
I635_13710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I635_13715	COG2976	Protein conserved in bacteria
I635_13740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I635_13750	COG2166	iron-sulfur cluster assembly
I635_13765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I635_13770	COG0719	Fe-S assembly protein
I635_13775	COG0396	ATPase activity
I635_13780	COG0719	Fe-S assembly protein
I635_13785	COG1104	cysteine desulfurase activity
I635_13795	COG2072	flavoprotein involved in K transport
I635_13800	COG1045	serine acetyltransferase
I635_13805	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I635_13810	COG0483	inositol monophosphate 1-phosphatase activity
I635_13825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I635_13830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I635_13835	COG1862	Preprotein translocase
I635_13840	COG0343	queuine tRNA-ribosyltransferase activity
I635_13860	COG1842	Phage shock protein A
I635_13865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I635_13885	COG0754	glutathionylspermidine amidase activity
I635_13915	COG2066	Belongs to the glutaminase family
I635_13920	COG1785	Belongs to the alkaline phosphatase family
I635_13975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I635_13995	COG0438	transferase activity, transferring glycosyl groups
I635_14015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I635_14020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I635_14050	COG2755	lipolytic protein G-D-S-L family
I635_14050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I635_14055	COG0367	asparagine synthase
I635_14060	COG0438	transferase activity, transferring glycosyl groups
I635_14070	COG2244	polysaccharide biosynthetic process
I635_14100	COG0367	asparagine synthase
I635_14135	COG0489	protein tyrosine kinase activity
I635_14145	COG3267	Type II secretory pathway component ExeA
I635_14145	COG3409	Peptidoglycan-binding domain 1 protein
I635_14205	COG1560	Kdo2-lipid A biosynthetic process
I635_14220	COG1960	acyl-CoA dehydrogenase activity
I635_14235	COG5001	Diguanylate cyclase
I635_14235	COG3300	MHYT domain
I635_14240	COG1435	thymidine kinase activity
I635_14250	COG1609	Transcriptional regulator
I635_14255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I635_14285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I635_14290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I635_14295	COG1250	3-hydroxyacyl-CoA dehydrogenase
I635_14295	COG1024	Enoyl-CoA hydratase
I635_14310	COG1012	belongs to the aldehyde dehydrogenase family
I635_14330	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I635_14355	COG1960	acyl-CoA dehydrogenase activity
I635_14385	COG0745	RESPONSE REGULATOR receiver
I635_14390	COG2205	protein histidine kinase activity
I635_14430	COG2080	2 iron, 2 sulfur cluster binding
I635_14435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I635_14440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I635_14460	COG1028	Short-chain dehydrogenase reductase Sdr
I635_14465	COG4221	oxidoreductase activity
I635_14470	COG0693	protein deglycase activity
I635_14475	COG1295	ribonuclease BN
I635_14485	COG4681	YaeQ
I635_14515	COG2814	Major facilitator Superfamily
I635_14530	COG0514	ATP-dependent DNA helicase (RecQ)
I635_14560	COG4251	negative regulation of phosphorylation
I635_14565	COG2133	pyrroloquinoline quinone binding
I635_14570	COG3609	addiction module antidote protein, CC2985 family
I635_14605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I635_14610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_14625	COG0330	HflC and HflK could
I635_14720	COG4772	TonB-dependent receptor
I635_14755	COG1230	cation diffusion facilitator family transporter
I635_14765	COG4372	Transposase
I635_14780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I635_14780	COG1017	nitric oxide dioxygenase activity
I635_14785	COG3604	Transcriptional regulator
I635_14815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I635_14820	COG2971	BadF BadG BcrA BcrD
I635_14825	COG0583	DNA-binding transcription factor activity
I635_14830	COG1620	l-lactate permease
I635_14855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_14860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I635_14865	COG0006	proline dipeptidase activity
I635_14875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I635_14890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I635_14895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I635_14900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I635_14920	COG3313	Fe-S protein
I635_14950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_14955	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_14960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I635_14965	COG2186	Transcriptional regulator
I635_14975	COG3023	N-Acetylmuramoyl-L-alanine amidase
I635_14980	COG3577	Aspartyl protease
I635_14985	COG0157	Belongs to the NadC ModD family
I635_14995	COG1459	type II secretion system
I635_15000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I635_15010	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I635_15020	COG3608	succinylglutamate desuccinylase aspartoacylase
I635_15025	COG0494	nUDIX hydrolase
I635_15035	COG0739	heme binding
I635_15040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I635_15045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I635_15050	COG0849	cell division
I635_15055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I635_15060	COG1181	Belongs to the D-alanine--D-alanine ligase family
I635_15065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I635_15075	COG0772	Belongs to the SEDS family
I635_15080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I635_15090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I635_15095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I635_15100	COG0768	penicillin binding
I635_15105	COG3116	cell division
I635_15115	COG2001	Belongs to the MraZ family
I635_15165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I635_15165	COG0678	peroxiredoxin activity
I635_15180	COG3706	GGDEF domain
I635_15190	COG2204	response regulator
I635_15195	COG0784	Response regulator, receiver
I635_15195	COG2205	protein histidine kinase activity
I635_15225	COG0668	transmembrane transport
I635_15230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I635_15235	COG0189	ligase activity
I635_15240	COG1678	Uncharacterized ACR, COG1678
I635_15245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I635_15270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I635_15275	COG0762	integral membrane protein
I635_15285	COG0446	pyridine nucleotide-disulphide oxidoreductase
I635_15285	COG1902	pentaerythritol trinitrate reductase activity
I635_15300	COG0625	glutathione transferase activity
I635_15310	COG1764	response to oxidative stress
I635_15315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I635_15330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I635_15340	COG2814	Major facilitator Superfamily
I635_15345	COG0724	RNA recognition motif
I635_15380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I635_15385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I635_15405	COG0583	DNA-binding transcription factor activity
I635_15420	COG0640	Transcriptional regulator
I635_15430	COG0431	NADPH-dependent FMN reductase
I635_15435	COG0798	PFAM Bile acid sodium symporter
I635_15440	COG2201	protein-glutamate methylesterase activity
I635_15445	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I635_15455	COG0642	Histidine kinase
I635_15480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I635_15510	COG1748	Saccharopine dehydrogenase
I635_15525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I635_15530	COG3107	peptidoglycan biosynthetic process
I635_15540	COG0438	transferase activity, transferring glycosyl groups
I635_15550	COG2823	Periplasmic or secreted lipoprotein
I635_15570	COG4585	Histidine kinase
I635_15575	COG2197	response regulator
I635_15590	COG4771	TonB-dependent receptor
I635_15600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I635_15605	COG0372	Belongs to the citrate synthase family
I635_15610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I635_15615	COG2828	Protein conserved in bacteria
I635_15620	COG2199	diguanylate cyclase activity
I635_15620	COG2203	Gaf domain
I635_15625	COG1940	carbohydrate kinase activity
I635_15665	COG2198	Histidine kinase
I635_15665	COG5002	protein histidine kinase activity
I635_15665	COG0784	Response regulator, receiver
I635_15670	COG3023	N-Acetylmuramoyl-L-alanine amidase
I635_15675	COG0069	glutamate synthase activity
I635_15675	COG0070	glutamate synthase
I635_15675	COG0067	glutamate synthase
I635_15680	COG0493	'glutamate synthase
I635_15695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I635_15700	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I635_15705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I635_15710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I635_15725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I635_15730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I635_15740	COG4942	peptidase
I635_15745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I635_15750	COG0738	Major facilitator superfamily
I635_15760	COG1902	pentaerythritol trinitrate reductase activity
I635_15780	COG0625	glutathione transferase activity
I635_15805	COG2894	cell division
I635_15810	COG0850	regulation of cytokinetic process
I635_15820	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I635_15850	COG1914	H( )-stimulated, divalent metal cation uptake system
I635_15855	COG0436	Aminotransferase
I635_15875	COG0174	glutamine synthetase
I635_15885	COG3852	Histidine kinase
I635_15890	COG2204	response regulator
I635_15895	COG3437	response regulator, receiver
I635_15900	COG0204	Acyl-transferase
I635_15940	COG2205	protein histidine kinase activity
I635_15940	COG3437	response regulator, receiver
I635_15940	COG3850	Histidine kinase
I635_15940	COG4999	Histidine kinase
I635_15945	COG0525	valine-tRNA ligase activity
I635_15950	COG2927	DNA polymerase III (CHI subunit)
I635_15955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I635_15960	COG0795	lipopolysaccharide-transporting ATPase activity
I635_15965	COG0795	lipopolysaccharide-transporting ATPase activity
I635_16050	COG4974	Belongs to the 'phage' integrase family
I635_16065	COG2856	Zn peptidase
I635_16180	COG3250	beta-galactosidase activity
I635_16190	COG4948	Mandelate Racemase Muconate Lactonizing
I635_16195	COG3661	Belongs to the glycosyl hydrolase 67 family
I635_16210	COG2203	Gaf domain
I635_16210	COG2199	diguanylate cyclase activity
I635_16235	COG0673	inositol 2-dehydrogenase activity
I635_16240	COG2205	protein histidine kinase activity
I635_16240	COG0784	Response regulator, receiver
I635_16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I635_16240	COG2198	Histidine kinase
I635_16245	COG0628	permease
I635_16260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I635_16265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I635_16270	COG4558	Periplasmic binding protein
I635_16280	COG4206	TonB-dependent receptor
I635_16290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I635_16295	COG0697	spore germination
I635_16320	COG1971	Probably functions as a manganese efflux pump
I635_16330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I635_16345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I635_16360	COG0679	Auxin Efflux Carrier
I635_16390	COG1131	(ABC) transporter
I635_16400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I635_16410	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I635_16450	COG2205	protein histidine kinase activity
I635_16460	COG0348	domain, Protein
I635_16460	COG3901	Regulator of nitric oxide reductase transcription
I635_16470	COG2197	response regulator
I635_16495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I635_16510	COG4771	TonB-dependent receptor
I635_16520	COG0583	DNA-binding transcription factor activity
I635_16525	COG1304	FMN binding
I635_16530	COG0277	FAD linked oxidase domain protein
I635_16540	COG1462	curli production assembly transport component CsgG
I635_16570	COG2197	response regulator
I635_16585	COG0513	Belongs to the DEAD box helicase family
I635_16600	COG1294	oxidase, subunit
I635_16605	COG1271	oxidase subunit
I635_16620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I635_16630	COG2124	cytochrome p450
I635_16650	COG2199	diguanylate cyclase activity
I635_16650	COG2203	Gaf domain
I635_16700	COG2337	Toxic component of a toxin-antitoxin (TA) module
I635_16730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I635_16755	COG1271	oxidase subunit
I635_16760	COG1294	oxidase, subunit
I635_16795	COG3264	Mechanosensitive ion channel
I635_16795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I635_16840	COG0730	response to heat
I635_16860	COG4191	Histidine kinase
I635_16870	COG0417	DNA replication proofreading
I635_16880	COG0318	PFAM AMP-dependent synthetase and ligase
I635_16900	COG1309	transcriptional regulator
I635_16910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_16920	COG1573	uracil-dna glycosylase
I635_16925	COG3300	MHYT domain
I635_16925	COG5001	Diguanylate cyclase
I635_16945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I635_16965	COG1983	PspC domain protein
I635_16970	COG1842	Phage shock protein A
I635_16980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_17000	COG2885	chlorophyll binding
I635_17000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I635_17005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I635_17015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I635_17020	COG0204	Acyl-transferase
I635_17025	COG0204	Acyl-transferase
I635_17030	COG0668	transmembrane transport
I635_17045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I635_17050	COG0733	neurotransmitter:sodium symporter activity
I635_17065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I635_17080	COG0716	FMN binding
I635_17090	COG0848	biopolymer transport protein
I635_17105	COG0457	Tetratricopeptide repeat
I635_17110	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I635_17120	COG1215	transferase activity, transferring glycosyl groups
I635_17135	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I635_17140	COG0702	epimerase
I635_17155	COG5001	Diguanylate cyclase
I635_17155	COG5002	protein histidine kinase activity
I635_17170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I635_17180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_17190	COG0583	DNA-binding transcription factor activity
I635_17195	COG0121	glutamine amidotransferase
I635_17200	COG4682	membrane
I635_17220	COG1953	Uracil, thiamine, allantoin
I635_17225	COG4771	TonB-dependent receptor
I635_17235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I635_17240	COG0778	Nitroreductase
I635_17245	COG0596	Alpha beta hydrolase
I635_17250	COG0251	oxidation-reduction process
I635_17255	COG1335	isochorismatase
I635_17260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_17265	COG1309	transcriptional regulator
I635_17280	COG4628	conserved protein (DUF2132)
I635_17285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I635_17295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I635_17305	COG1477	protein flavinylation
I635_17310	COG2871	sodium ion transport
I635_17315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_17320	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_17325	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_17330	COG1805	sodium ion transport
I635_17335	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I635_17340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I635_17345	COG0545	Peptidyl-prolyl cis-trans isomerase
I635_17350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I635_17355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I635_17370	COG0039	L-malate dehydrogenase activity
I635_17375	COG1438	arginine binding
I635_17400	COG0572	uridine kinase
I635_17405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I635_17425	COG3706	GGDEF domain
I635_17425	COG0745	RESPONSE REGULATOR receiver
I635_17430	COG2176	DNA-directed DNA polymerase activity
I635_17435	COG1125	glycine betaine transport
I635_17435	COG0517	IMP dehydrogenase activity
I635_17440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I635_17450	COG2205	protein histidine kinase activity
I635_17460	COG0189	ligase activity
I635_17470	COG4067	protein conserved in archaea
I635_17470	COG0189	ligase activity
I635_17495	COG1283	sodium-dependent phosphate transmembrane transporter activity
I635_17500	COG0667	Aldo Keto reductase
I635_17515	COG5001	Diguanylate cyclase
I635_17530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I635_17540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I635_17545	COG0840	transmembrane signaling receptor activity
I635_17570	COG2274	protein secretion by the type I secretion system
I635_17575	COG0583	DNA-binding transcription factor activity
I635_17600	COG0438	transferase activity, transferring glycosyl groups
I635_17600	COG1216	Glycosyl transferase, family 2
I635_17640	COG0457	Tetratricopeptide repeat
I635_17680	COG0463	Glycosyl transferase, family 2
I635_17680	COG1216	Glycosyl transferase, family 2
I635_17770	COG4372	Transposase
I635_17790	COG4372	Transposase
I635_17840	COG2161	toxin-antitoxin pair type II binding
I635_17850	COG0202	RNA polymerase activity
I635_17875	COG0201	protein transport
I635_17895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I635_17930	COG5002	protein histidine kinase activity
I635_17930	COG0784	Response regulator, receiver
I635_17955	COG0557	exoribonuclease II activity
I635_17985	COG4771	TonB-dependent receptor
I635_18000	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I635_18015	COG0543	2 iron, 2 sulfur cluster binding
I635_18030	COG2234	aminopeptidase activity
I635_18040	COG4251	negative regulation of phosphorylation
I635_18050	COG1271	oxidase subunit
I635_18055	COG1294	oxidase, subunit
I635_18065	COG1522	sequence-specific DNA binding
I635_18075	COG1278	Cold shock
I635_18080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I635_18100	COG0339	signal peptide processing
I635_18105	COG2201	protein-glutamate methylesterase activity
I635_18115	COG3852	Histidine kinase
I635_18125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I635_18130	COG0243	molybdopterin cofactor binding
I635_18135	COG4946	Tricorn protease homolog
I635_18135	COG0823	Involved in the tonB-independent uptake of proteins
I635_18135	COG1506	peptidase
I635_18185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I635_18195	COG2197	response regulator
I635_18205	COG0189	ligase activity
I635_18225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I635_18230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I635_18235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I635_18250	COG0281	malic enzyme
I635_18260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I635_18290	COG0456	acetyltransferase
I635_18300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I635_18305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I635_18310	COG2177	Part of the ABC transporter FtsEX involved in
I635_18315	COG2884	Cell division ATP-binding protein ftsE
I635_18320	COG0552	protein localization to endoplasmic reticulum
I635_18330	COG0742	ribosomal rna small subunit methyltransferase
I635_18340	COG2095	MarC family integral membrane protein
I635_18360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I635_18365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I635_18370	COG0617	tRNA 3'-terminal CCA addition
I635_18375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I635_18390	COG0076	glutamate decarboxylase activity
I635_18410	COG0842	Transport permease protein
I635_18415	COG1131	(ABC) transporter
I635_18420	COG0745	RESPONSE REGULATOR receiver
I635_18425	COG2205	protein histidine kinase activity
I635_18430	COG4774	siderophore transport
I635_18450	COG1253	flavin adenine dinucleotide binding
I635_18505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I635_18510	COG0049	tRNA binding
I635_18515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I635_18520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I635_18525	COG0085	RNA polymerase activity
I635_18535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I635_18540	COG0081	regulation of translation
I635_18545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I635_18565	COG0250	Participates in transcription elongation, termination and antitermination
I635_18570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I635_18575	COG1132	(ABC) transporter
I635_18580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I635_18585	COG3590	peptidase
I635_18595	COG0513	Belongs to the DEAD box helicase family
I635_18600	COG0418	dihydroorotase activity
I635_18605	COG3040	lipid binding
I635_18610	COG4989	oxidoreductase activity
I635_18615	COG0346	lactoylglutathione lyase activity
I635_18620	COG0668	transmembrane transport
I635_18640	COG0302	gtp cyclohydrolase
I635_18650	COG2957	Belongs to the agmatine deiminase family
I635_18655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I635_18670	COG1201	RNA secondary structure unwinding
I635_18680	COG1793	dna ligase
I635_18685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I635_18690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I635_18700	COG0646	methionine synthase
I635_18700	COG1410	methionine synthase
I635_18705	COG0625	glutathione transferase activity
I635_18710	COG0625	glutathione transferase activity
I635_18720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I635_18735	COG1012	belongs to the aldehyde dehydrogenase family
I635_18740	COG0028	Belongs to the TPP enzyme family
I635_18750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I635_18755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I635_18760	COG0330	HflC and HflK could
I635_18765	COG0330	HflC and HflK could
I635_18770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I635_18775	COG1923	regulation of RNA biosynthetic process
I635_18780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I635_18795	COG0802	atpase or kinase
I635_18800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I635_18800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I635_18805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I635_18815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I635_18825	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I635_18830	COG0735	belongs to the Fur family
I635_18840	COG0432	Pfam Uncharacterised protein family UPF0047
I635_18850	COG0305	Participates in initiation and elongation during chromosome replication
I635_18875	COG2258	MOSC domain
I635_18905	COG2205	protein histidine kinase activity
I635_18925	COG0840	transmembrane signaling receptor activity
I635_18930	COG5002	protein histidine kinase activity
I635_18970	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_18980	COG2723	6-phospho-beta-galactosidase activity
I635_18985	COG1609	Transcriptional regulator
I635_18990	COG0477	Major facilitator Superfamily
I635_18990	COG2814	Major facilitator Superfamily
I635_18995	COG4319	ketosteroid isomerase
I635_19015	COG2375	cellular response to nickel ion
I635_19020	COG3237	CsbD-like
I635_19050	COG0508	dehydrogenase complex catalyzes the overall conversion of
I635_19050	COG0596	Alpha beta hydrolase
I635_19070	COG3038	cytochrome b561
I635_19080	COG1252	NADH dehydrogenase
I635_19095	COG0583	DNA-binding transcription factor activity
I635_19100	COG2067	long-chain fatty acid transport protein
I635_19105	COG2130	NADP-dependent
I635_19110	COG2203	Gaf domain
I635_19110	COG3706	GGDEF domain
I635_19110	COG4251	negative regulation of phosphorylation
I635_19110	COG5001	Diguanylate cyclase
I635_19115	COG0784	Response regulator, receiver
I635_19115	COG2205	protein histidine kinase activity
I635_19125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I635_19130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I635_19135	COG1349	DNA-binding transcription factor activity
I635_19140	COG0673	inositol 2-dehydrogenase activity
I635_19155	COG0697	spore germination
I635_19160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I635_19165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I635_19170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I635_19175	COG1166	arginine decarboxylase activity
I635_19185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I635_19190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I635_19195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I635_19265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I635_19270	COG0109	protoheme IX farnesyltransferase activity
I635_19290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I635_19335	COG3030	protein affecting phage T7 exclusion by the F plasmid
I635_19340	COG1324	tolerance protein
I635_19345	COG4232	protein-disulfide reductase activity
I635_19350	COG0739	heme binding
I635_19355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I635_19360	COG0511	ligase activity, forming carbon-carbon bonds
I635_19365	COG0439	Biotin carboxylase
I635_19415	COG0154	amidase activity
I635_19430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I635_19435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I635_19450	COG0151	Belongs to the GarS family
I635_19465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I635_19470	COG3954	Phosphoribulokinase
I635_19480	COG0745	RESPONSE REGULATOR receiver
I635_19500	COG1501	Belongs to the glycosyl hydrolase 31 family
I635_19515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I635_19525	COG3031	protein transport across the cell outer membrane
I635_19535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I635_19540	COG1459	type II secretion system
I635_19545	COG2165	general secretion pathway protein
I635_19550	COG2165	general secretion pathway protein
I635_19555	COG2165	general secretion pathway protein
I635_19560	COG4795	General secretion pathway protein
I635_19575	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I635_19590	COG1012	belongs to the aldehyde dehydrogenase family
I635_19600	COG1011	Hydrolase
I635_19605	COG0494	nUDIX hydrolase
I635_19610	COG1218	3'(2'),5'-bisphosphate nucleotidase
I635_19625	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I635_19635	COG3089	Belongs to the UPF0270 family
I635_19640	COG0429	hydrolase of the alpha beta-hydrolase fold
I635_19650	COG0488	(ABC) transporter
I635_19670	COG2900	Belongs to the SlyX family
I635_19680	COG0545	Peptidyl-prolyl cis-trans isomerase
I635_19690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I635_19695	COG2183	response to ionizing radiation
I635_19725	COG1609	Transcriptional regulator
I635_19725	COG2207	Transcriptional regulator
I635_19730	COG2211	Major facilitator Superfamily
I635_19745	COG3693	PFAM glycoside hydrolase, family 10
I635_19750	COG0667	Aldo Keto reductase
I635_19755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I635_19760	COG2115	Belongs to the xylose isomerase family
I635_19765	COG1070	Carbohydrate kinase
I635_19780	COG1472	Belongs to the glycosyl hydrolase 3 family
I635_19785	COG0477	Major facilitator Superfamily
I635_19830	COG0596	Alpha beta hydrolase
I635_19835	COG1040	competence protein
I635_19855	COG1794	racemase activity, acting on amino acids and derivatives
I635_19865	COG0534	Mate efflux family protein
I635_19880	COG1999	signal sequence binding
I635_19885	COG0109	protoheme IX farnesyltransferase activity
I635_19890	COG1612	heme a metabolic process
I635_19910	COG1845	cytochrome c oxidase, subunit III
I635_19915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I635_19920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I635_19925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I635_19945	COG0129	dihydroxy-acid dehydratase activity
I635_19955	COG0606	chelatase, subunit chli
I635_19960	COG0583	DNA-binding transcription factor activity
I635_19970	COG2814	Major facilitator Superfamily
I635_19980	COG0729	surface antigen
I635_19985	COG2911	Protein conserved in bacteria
I635_20010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I635_20020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I635_20040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I635_20065	COG1228	amidohydrolase
I635_20090	COG0425	Belongs to the sulfur carrier protein TusA family
I635_20110	COG1561	YicC-like family, N-terminal region
I635_20125	COG3550	peptidyl-serine autophosphorylation
I635_20130	COG3620	sequence-specific DNA binding
I635_20200	COG5433	transposase activity
I635_20205	COG3119	arylsulfatase activity
I635_20210	COG0714	Associated with various cellular activities
I635_20225	COG2304	oxidoreductase activity
I635_20260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I635_20270	COG1960	acyl-CoA dehydrogenase activity
I635_20280	COG1024	Enoyl-CoA hydratase
I635_20290	COG2801	Transposase and inactivated derivatives
I635_20300	COG0800	Aldolase
I635_20310	COG0129	dihydroxy-acid dehydratase activity
I635_20320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I635_20325	COG1737	Transcriptional regulator
I635_20330	COG0469	pyruvate kinase activity
I635_20360	COG3177	Filamentation induced by cAMP protein fic
I635_20370	COG1609	Transcriptional regulator
I635_20385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I635_20385	COG2199	diguanylate cyclase activity
I635_20410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I635_20430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I635_20435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I635_20455	COG1475	DNA binding
I635_20460	COG1192	Involved in chromosome partitioning
I635_20490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I635_20495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I635_20505	COG0706	membrane insertase activity
I635_20510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I635_20515	COG0594	ribonuclease P activity
I635_20520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I635_21234	COG1132	(ABC) transporter
I635_21254	COG2801	Transposase and inactivated derivatives
I635_21334	COG2201	protein-glutamate methylesterase activity
I635_21379	COG5290	Psort location Cytoplasmic, score
I635_21419	COG3209	COG3209 Rhs family protein
I635_21429	COG3209	COG3209 Rhs family protein
I635_21559	COG5310	Homospermidine synthase
I635_21584	COG3251	PFAM MbtH domain protein
I635_21754	COG0210	DNA helicase
I635_21794	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I635_21824	COG4584	PFAM Integrase catalytic
I635_21969	COG4584	PFAM Integrase catalytic
I635_21974	COG1484	DNA-dependent DNA replication
I635_21989	COG5001	Diguanylate cyclase
I635_21989	COG3300	MHYT domain
I635_22004	COG3706	GGDEF domain
I635_22089	COG1192	Involved in chromosome partitioning