locus-tag	class	description
IUA53_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IUA53_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IUA53_00020	COG0187	DNA topoisomerase II activity
IUA53_00040	COG2818	Glycosylase
IUA53_00050	COG3078	GTPase activator activity
IUA53_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUA53_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IUA53_00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IUA53_00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IUA53_00085	COG0569	domain protein
IUA53_00090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IUA53_00090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IUA53_00095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_00105	COG1652	LysM domain
IUA53_00110	COG0758	DNA mediated transformation
IUA53_00125	COG0009	L-threonylcarbamoyladenylate synthase
IUA53_00130	COG0408	coproporphyrinogen oxidase activity
IUA53_00135	COG3047	cAMP biosynthetic process
IUA53_00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUA53_00220	COG2234	aminopeptidase activity
IUA53_00225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IUA53_00240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUA53_00265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_00295	COG3642	lipopolysaccharide core region biosynthetic process
IUA53_00300	COG0859	PFAM glycosyl transferase family 9
IUA53_00320	COG0156	8-amino-7-oxononanoate synthase activity
IUA53_00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_00335	COG0705	Rhomboid family
IUA53_00345	COG3161	chorismate lyase activity
IUA53_00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IUA53_00355	COG2960	long-chain fatty acid transporting porin activity
IUA53_00360	COG0210	DNA helicase
IUA53_00405	COG0270	DNA (cytosine-5-)-methyltransferase activity
IUA53_00410	COG0556	nucleotide-excision repair
IUA53_00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_00425	COG0842	Transport permease protein
IUA53_00425	COG1129	ABC transporter
IUA53_00430	COG0842	Transport permease protein
IUA53_00435	COG4773	Receptor
IUA53_00440	COG4771	TonB-dependent receptor
IUA53_00445	COG3385	transposase activity
IUA53_00455	COG0583	DNA-binding transcription factor activity
IUA53_00465	COG3106	COG3106 Predicted ATPase
IUA53_00480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IUA53_00500	COG0352	thiamine-phosphate diphosphorylase activity
IUA53_00510	COG4771	TonB-dependent receptor
IUA53_00525	COG0778	Nitroreductase
IUA53_00525	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IUA53_00535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IUA53_00540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IUA53_00545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IUA53_00550	COG1309	transcriptional regulator
IUA53_00575	COG1953	Uracil, thiamine, allantoin
IUA53_00585	COG3071	HemY protein
IUA53_00590	COG2959	enzyme of heme biosynthesis
IUA53_00595	COG1587	Uroporphyrinogen-III synthase
IUA53_00600	COG0181	hydroxymethylbilane synthase activity
IUA53_00615	COG0194	GDP metabolic process
IUA53_00625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUA53_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_00640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUA53_00650	COG0678	peroxiredoxin activity
IUA53_00665	COG1178	ABC-type Fe3 transport system permease component
IUA53_00670	COG3842	ATPase activity
IUA53_00675	COG0668	transmembrane transport
IUA53_00680	COG2081	HI0933 family
IUA53_00760	COG4774	siderophore transport
IUA53_00770	COG0501	Belongs to the peptidase M48B family
IUA53_00775	COG0745	RESPONSE REGULATOR receiver
IUA53_00780	COG0457	Tetratricopeptide repeat
IUA53_00805	COG0010	Belongs to the arginase family
IUA53_00810	COG0010	Belongs to the arginase family
IUA53_00815	COG0784	Response regulator, receiver
IUA53_00815	COG2198	Histidine kinase
IUA53_00815	COG5002	protein histidine kinase activity
IUA53_00830	COG1172	Belongs to the binding-protein-dependent transport system permease family
IUA53_00845	COG0829	nickel cation binding
IUA53_00850	COG0831	urea catabolic process
IUA53_00870	COG0830	nickel cation binding
IUA53_00890	COG3706	GGDEF domain
IUA53_00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_00935	COG0427	acetyl-CoA hydrolase
IUA53_00940	COG0123	including yeast histone deacetylase and acetoin utilization protein
IUA53_00965	COG3064	Membrane
IUA53_00975	COG5001	Diguanylate cyclase
IUA53_00975	COG5002	protein histidine kinase activity
IUA53_00990	COG0514	ATP-dependent DNA helicase (RecQ)
IUA53_01000	COG2239	Acts as a magnesium transporter
IUA53_01005	COG2962	Rard protein
IUA53_01015	COG0210	DNA helicase
IUA53_01025	COG1011	Hydrolase
IUA53_01040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IUA53_01045	COG0019	diaminopimelate decarboxylase activity
IUA53_01075	COG0163	prenyltransferase activity
IUA53_01080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUA53_01090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IUA53_01115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IUA53_01120	COG2814	Major facilitator Superfamily
IUA53_01125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_01155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IUA53_01165	COG0629	single-stranded DNA binding
IUA53_01195	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_01210	COG1349	DNA-binding transcription factor activity
IUA53_01230	COG1077	Cell shape determining protein MreB Mrl
IUA53_01235	COG1792	Involved in formation and maintenance of cell shape
IUA53_01240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUA53_01245	COG0424	maF-like protein
IUA53_01250	COG1530	ribonuclease E activity
IUA53_01255	COG3164	Protein of unknown function
IUA53_01260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_01265	COG0312	modulator of DNA gyrase
IUA53_01270	COG3028	Belongs to the UPF0307 family
IUA53_01275	COG0312	modulator of DNA gyrase
IUA53_01290	COG0745	RESPONSE REGULATOR receiver
IUA53_01295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_01295	COG4191	Histidine kinase
IUA53_01300	COG0297	glycogen (starch) synthase activity
IUA53_01310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IUA53_01360	COG0732	type I restriction modification DNA specificity domain
IUA53_01395	COG3341	Caulimovirus viroplasmin
IUA53_01395	COG0328	RNA-DNA hybrid ribonuclease activity
IUA53_01415	COG4974	Belongs to the 'phage' integrase family
IUA53_01520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUA53_01555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUA53_01565	COG0463	Glycosyl transferase, family 2
IUA53_01570	COG0745	RESPONSE REGULATOR receiver
IUA53_01575	COG5002	protein histidine kinase activity
IUA53_01615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_01635	COG0789	Transcriptional regulator
IUA53_01640	COG2217	Heavy metal translocating P-type atpase
IUA53_01680	COG0531	amino acid
IUA53_01690	COG2132	Multicopper oxidase
IUA53_01770	COG2378	regulation of single-species biofilm formation
IUA53_01780	COG4771	TonB-dependent receptor
IUA53_01800	COG0840	transmembrane signaling receptor activity
IUA53_01805	COG0745	RESPONSE REGULATOR receiver
IUA53_01810	COG0643	Histidine kinase
IUA53_01810	COG2198	Histidine kinase
IUA53_01815	COG0835	chemotaxis
IUA53_01830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IUA53_01860	COG3437	response regulator, receiver
IUA53_01865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IUA53_01880	COG1609	Transcriptional regulator
IUA53_01885	COG0673	inositol 2-dehydrogenase activity
IUA53_01895	COG2211	Major facilitator Superfamily
IUA53_01920	COG0346	lactoylglutathione lyase activity
IUA53_01925	COG4989	oxidoreductase activity
IUA53_01930	COG3040	lipid binding
IUA53_01940	COG0418	dihydroorotase activity
IUA53_01945	COG0513	Belongs to the DEAD box helicase family
IUA53_01955	COG3590	peptidase
IUA53_01960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IUA53_01970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_01975	COG1132	(ABC) transporter
IUA53_01985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUA53_01990	COG0250	Participates in transcription elongation, termination and antitermination
IUA53_02000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IUA53_02005	COG0081	regulation of translation
IUA53_02010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IUA53_02015	COG0222	ribosome binding
IUA53_02020	COG0085	RNA polymerase activity
IUA53_02025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IUA53_02030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IUA53_02035	COG0049	tRNA binding
IUA53_02040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUA53_02050	COG0657	acetylesterase activity
IUA53_02060	COG1966	Carbon starvation protein
IUA53_02065	COG0701	Predicted permease
IUA53_02070	COG1253	flavin adenine dinucleotide binding
IUA53_02090	COG4774	siderophore transport
IUA53_02095	COG2205	protein histidine kinase activity
IUA53_02100	COG0745	RESPONSE REGULATOR receiver
IUA53_02105	COG1131	(ABC) transporter
IUA53_02110	COG0842	Transport permease protein
IUA53_02120	COG0076	glutamate decarboxylase activity
IUA53_02135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUA53_02150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IUA53_02170	COG2095	MarC family integral membrane protein
IUA53_02180	COG0742	ribosomal rna small subunit methyltransferase
IUA53_02185	COG0552	protein localization to endoplasmic reticulum
IUA53_02190	COG2884	Cell division ATP-binding protein ftsE
IUA53_02195	COG2177	Part of the ABC transporter FtsEX involved in
IUA53_02200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_02205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IUA53_02215	COG0456	acetyltransferase
IUA53_02245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUA53_02255	COG0281	malic enzyme
IUA53_02270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUA53_02275	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUA53_02280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IUA53_02320	COG4946	Tricorn protease homolog
IUA53_02320	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_02320	COG1506	peptidase
IUA53_02325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_02335	COG4191	Histidine kinase
IUA53_02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_02345	COG2201	protein-glutamate methylesterase activity
IUA53_02350	COG0339	signal peptide processing
IUA53_02370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IUA53_02375	COG1278	Cold shock
IUA53_02385	COG0840	transmembrane signaling receptor activity
IUA53_02390	COG1294	oxidase, subunit
IUA53_02395	COG1271	oxidase subunit
IUA53_02430	COG2234	aminopeptidase activity
IUA53_02455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IUA53_02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_02485	COG0784	Response regulator, receiver
IUA53_02485	COG2205	protein histidine kinase activity
IUA53_02520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IUA53_02540	COG0201	protein transport
IUA53_02565	COG0202	RNA polymerase activity
IUA53_02575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_02585	COG0662	Cupin 2, conserved barrel domain protein
IUA53_02585	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IUA53_02670	COG1091	dTDP-4-dehydrorhamnose reductase activity
IUA53_02680	COG0438	transferase activity, transferring glycosyl groups
IUA53_02680	COG1216	Glycosyl transferase, family 2
IUA53_02695	COG1216	Glycosyl transferase, family 2
IUA53_02695	COG1442	glycosyl transferase family 8
IUA53_02710	COG0463	Glycosyl transferase, family 2
IUA53_02715	COG1216	Glycosyl transferase, family 2
IUA53_02745	COG0583	DNA-binding transcription factor activity
IUA53_02795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IUA53_02805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IUA53_02840	COG0753	catalase activity
IUA53_02855	COG0667	Aldo Keto reductase
IUA53_02860	COG1283	sodium-dependent phosphate transmembrane transporter activity
IUA53_02870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IUA53_02885	COG4067	protein conserved in archaea
IUA53_02885	COG0189	ligase activity
IUA53_02895	COG0189	ligase activity
IUA53_02905	COG0784	Response regulator, receiver
IUA53_02905	COG2198	Histidine kinase
IUA53_02905	COG5002	protein histidine kinase activity
IUA53_02915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_02920	COG0517	IMP dehydrogenase activity
IUA53_02920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IUA53_02945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IUA53_02950	COG0572	uridine kinase
IUA53_02980	COG4206	TonB-dependent receptor
IUA53_02985	COG1438	arginine binding
IUA53_02990	COG0039	L-malate dehydrogenase activity
IUA53_03005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IUA53_03010	COG0545	Peptidyl-prolyl cis-trans isomerase
IUA53_03015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IUA53_03020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_03025	COG1805	sodium ion transport
IUA53_03030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_03035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_03040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IUA53_03045	COG2871	sodium ion transport
IUA53_03050	COG1477	protein flavinylation
IUA53_03060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IUA53_03075	COG1609	Transcriptional regulator
IUA53_03080	COG3265	gluconokinase activity
IUA53_03085	COG2610	gluconate transmembrane transporter activity
IUA53_03090	COG4628	conserved protein (DUF2132)
IUA53_03105	COG0577	efflux transmembrane transporter activity
IUA53_03105	COG1136	(ABC) transporter
IUA53_03115	COG1522	sequence-specific DNA binding
IUA53_03140	COG0121	glutamine amidotransferase
IUA53_03155	COG0583	DNA-binding transcription factor activity
IUA53_03165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUA53_03170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IUA53_03180	COG5001	Diguanylate cyclase
IUA53_03180	COG5002	protein histidine kinase activity
IUA53_03200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IUA53_03210	COG0848	biopolymer transport protein
IUA53_03220	COG0716	FMN binding
IUA53_03235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUA53_03250	COG0733	neurotransmitter:sodium symporter activity
IUA53_03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUA53_03270	COG0668	transmembrane transport
IUA53_03275	COG0204	Acyl-transferase
IUA53_03280	COG0204	Acyl-transferase
IUA53_03295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IUA53_03310	COG4529	Protein conserved in bacteria
IUA53_03325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_03335	COG1842	Phage shock protein A
IUA53_03360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUA53_03385	COG1573	uracil-dna glycosylase
IUA53_03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_03460	COG3385	transposase activity
IUA53_03470	COG0417	DNA replication proofreading
IUA53_03475	COG4191	Histidine kinase
IUA53_03490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_03495	COG0730	response to heat
IUA53_03510	COG3568	Endonuclease Exonuclease Phosphatase
IUA53_03525	COG0475	glutathione-regulated potassium exporter activity
IUA53_03525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUA53_03545	COG2207	Transcriptional regulator
IUA53_03550	COG3264	Mechanosensitive ion channel
IUA53_03550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IUA53_03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_03570	COG0800	Aldolase
IUA53_03580	COG0513	Belongs to the DEAD box helicase family
IUA53_03600	COG1116	anion transmembrane transporter activity
IUA53_03615	COG2267	carboxylic ester hydrolase activity
IUA53_03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_03655	COG1609	Transcriptional regulator
IUA53_03670	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_03680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IUA53_03690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IUA53_03695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IUA53_03700	COG4139	cobalamin transport
IUA53_03705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IUA53_03710	COG4206	TonB-dependent receptor
IUA53_03765	COG0793	Belongs to the peptidase S41A family
IUA53_03765	COG4946	Tricorn protease homolog
IUA53_03780	COG3661	Belongs to the glycosyl hydrolase 67 family
IUA53_03785	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_03805	COG3250	beta-galactosidase activity
IUA53_03845	COG1484	DNA-dependent DNA replication
IUA53_03850	COG4584	PFAM Integrase catalytic
IUA53_03890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_03930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUA53_03985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUA53_04065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_04070	COG3246	L-lysine catabolic process to acetate
IUA53_04080	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_04085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_04090	COG1414	Transcriptional regulator
IUA53_04100	COG0795	lipopolysaccharide-transporting ATPase activity
IUA53_04105	COG0795	lipopolysaccharide-transporting ATPase activity
IUA53_04110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IUA53_04115	COG2927	DNA polymerase III (CHI subunit)
IUA53_04120	COG0525	valine-tRNA ligase activity
IUA53_04155	COG3437	response regulator, receiver
IUA53_04160	COG2204	response regulator
IUA53_04165	COG3852	Histidine kinase
IUA53_04175	COG0174	glutamine synthetase
IUA53_04180	COG1217	gtp-binding protein TYPA
IUA53_04190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IUA53_04195	COG1914	H( )-stimulated, divalent metal cation uptake system
IUA53_04210	COG1981	membrane
IUA53_04240	COG0850	regulation of cytokinetic process
IUA53_04245	COG2894	cell division
IUA53_04275	COG0625	glutathione transferase activity
IUA53_04295	COG5002	protein histidine kinase activity
IUA53_04295	COG0784	Response regulator, receiver
IUA53_04295	COG2205	protein histidine kinase activity
IUA53_04300	COG3437	response regulator, receiver
IUA53_04305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IUA53_04310	COG1196	nuclear chromosome segregation
IUA53_04310	COG0741	lytic transglycosylase activity
IUA53_04310	COG0739	heme binding
IUA53_04315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IUA53_04320	COG5507	3-demethylubiquinone-9 3-methyltransferase
IUA53_04330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_04340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IUA53_04355	COG0493	'glutamate synthase
IUA53_04360	COG0069	glutamate synthase activity
IUA53_04360	COG0070	glutamate synthase
IUA53_04360	COG0067	glutamate synthase
IUA53_04365	COG3023	N-Acetylmuramoyl-L-alanine amidase
IUA53_04370	COG5002	protein histidine kinase activity
IUA53_04370	COG2198	Histidine kinase
IUA53_04370	COG0784	Response regulator, receiver
IUA53_04390	COG2203	Gaf domain
IUA53_04390	COG2199	diguanylate cyclase activity
IUA53_04395	COG2828	Protein conserved in bacteria
IUA53_04400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IUA53_04405	COG0372	Belongs to the citrate synthase family
IUA53_04410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IUA53_04430	COG2823	Periplasmic or secreted lipoprotein
IUA53_04440	COG0792	nuclease activity
IUA53_04450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IUA53_04470	COG1748	Saccharopine dehydrogenase
IUA53_04480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IUA53_04495	COG2205	protein histidine kinase activity
IUA53_04505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IUA53_04510	COG2201	protein-glutamate methylesterase activity
IUA53_04515	COG0798	PFAM Bile acid sodium symporter
IUA53_04520	COG0431	NADPH-dependent FMN reductase
IUA53_04530	COG0640	Transcriptional regulator
IUA53_04545	COG0583	DNA-binding transcription factor activity
IUA53_04555	COG0083	homoserine kinase activity
IUA53_04560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IUA53_04565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IUA53_04595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IUA53_04625	COG1902	pentaerythritol trinitrate reductase activity
IUA53_04625	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUA53_04635	COG0762	integral membrane protein
IUA53_04640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IUA53_04645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUA53_04665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IUA53_04670	COG1678	Uncharacterized ACR, COG1678
IUA53_04680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUA53_04685	COG0668	transmembrane transport
IUA53_04690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_04730	COG2271	Major facilitator Superfamily
IUA53_04735	COG2084	Dehydrogenase
IUA53_04750	COG2204	response regulator
IUA53_04765	COG0678	peroxiredoxin activity
IUA53_04765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_04790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_04805	COG2001	Belongs to the MraZ family
IUA53_04815	COG3116	cell division
IUA53_04820	COG0768	penicillin binding
IUA53_04825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IUA53_04830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUA53_04840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IUA53_04845	COG0772	Belongs to the SEDS family
IUA53_04855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUA53_04860	COG1181	Belongs to the D-alanine--D-alanine ligase family
IUA53_04865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUA53_04870	COG0849	cell division
IUA53_04875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUA53_04880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IUA53_04885	COG0739	heme binding
IUA53_04900	COG3608	succinylglutamate desuccinylase aspartoacylase
IUA53_04905	COG1629	transport
IUA53_04910	COG0702	epimerase
IUA53_04915	COG2814	Major facilitator Superfamily
IUA53_04920	COG1621	beta-fructofuranosidase activity
IUA53_04940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IUA53_04945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IUA53_04950	COG0237	dephospho-CoA kinase activity
IUA53_04960	COG1459	type II secretion system
IUA53_04965	COG4969	Belongs to the N-Me-Phe pilin family
IUA53_04975	COG3577	Aspartyl protease
IUA53_04995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IUA53_05000	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUA53_05005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_05025	COG3313	Fe-S protein
IUA53_05045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUA53_05050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IUA53_05055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUA53_05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_05080	COG0006	proline dipeptidase activity
IUA53_05085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_05090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_05100	COG0006	proline dipeptidase activity
IUA53_05105	COG0583	DNA-binding transcription factor activity
IUA53_05120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IUA53_05120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IUA53_05130	COG1203	CRISPR-associated helicase, Cas3
IUA53_05165	COG1518	maintenance of DNA repeat elements
IUA53_05170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_05195	COG1312	Catalyzes the dehydration of D-mannonate
IUA53_05225	COG0235	Class ii aldolase
IUA53_05240	COG0513	Belongs to the DEAD box helicase family
IUA53_05255	COG4555	ABC transporter
IUA53_05265	COG3850	Histidine kinase
IUA53_05265	COG3437	response regulator, receiver
IUA53_05265	COG2205	protein histidine kinase activity
IUA53_05265	COG4999	Histidine kinase
IUA53_05270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IUA53_05275	COG1764	response to oxidative stress
IUA53_05280	COG0596	Alpha beta hydrolase
IUA53_05290	COG0784	Response regulator, receiver
IUA53_05290	COG2205	protein histidine kinase activity
IUA53_05290	COG5002	protein histidine kinase activity
IUA53_05310	COG2267	carboxylic ester hydrolase activity
IUA53_05315	COG0514	ATP-dependent DNA helicase (RecQ)
IUA53_05355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IUA53_05370	COG2115	Belongs to the xylose isomerase family
IUA53_05375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUA53_05380	COG1070	Carbohydrate kinase
IUA53_05410	COG2207	Transcriptional regulator
IUA53_05410	COG1609	Transcriptional regulator
IUA53_05420	COG0477	Major facilitator Superfamily
IUA53_05500	COG2197	response regulator
IUA53_05505	COG1295	ribonuclease BN
IUA53_05545	COG1595	DNA-templated transcription, initiation
IUA53_05555	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_05560	COG2233	PERMEase
IUA53_05580	COG0693	protein deglycase activity
IUA53_05625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_05645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IUA53_05650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IUA53_05655	COG2080	2 iron, 2 sulfur cluster binding
IUA53_05680	COG1960	acyl-CoA dehydrogenase activity
IUA53_05695	COG1484	DNA-dependent DNA replication
IUA53_05700	COG4584	PFAM Integrase catalytic
IUA53_05710	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IUA53_05725	COG1024	Enoyl-CoA hydratase
IUA53_05725	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_05735	COG0515	serine threonine protein kinase
IUA53_05735	COG2815	serine threonine protein kinase
IUA53_05750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IUA53_05755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IUA53_05790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IUA53_05795	COG1609	Transcriptional regulator
IUA53_05800	COG1435	thymidine kinase activity
IUA53_05820	COG1960	acyl-CoA dehydrogenase activity
IUA53_05830	COG1560	Kdo2-lipid A biosynthetic process
IUA53_05850	COG2827	Endonuclease containing a URI domain
IUA53_05860	COG3409	Peptidoglycan-binding domain 1 protein
IUA53_05860	COG3267	Type II secretory pathway component ExeA
IUA53_05870	COG0489	protein tyrosine kinase activity
IUA53_05935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_05935	COG2755	lipolytic protein G-D-S-L family
IUA53_05965	COG0367	asparagine synthase
IUA53_06000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IUA53_06065	COG0745	RESPONSE REGULATOR receiver
IUA53_06070	COG1785	Belongs to the alkaline phosphatase family
IUA53_06075	COG2066	Belongs to the glutaminase family
IUA53_06090	COG0754	glutathionylspermidine amidase activity
IUA53_06115	COG1842	Phage shock protein A
IUA53_06135	COG0343	queuine tRNA-ribosyltransferase activity
IUA53_06140	COG1862	Preprotein translocase
IUA53_06145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_06150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_06165	COG0483	inositol monophosphate 1-phosphatase activity
IUA53_06170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IUA53_06175	COG1045	serine acetyltransferase
IUA53_06185	COG1104	cysteine desulfurase activity
IUA53_06190	COG0719	Fe-S assembly protein
IUA53_06195	COG0396	ATPase activity
IUA53_06200	COG0719	Fe-S assembly protein
IUA53_06205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IUA53_06220	COG2166	iron-sulfur cluster assembly
IUA53_06230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IUA53_06240	COG1426	Protein conserved in bacteria
IUA53_06255	COG2976	Protein conserved in bacteria
IUA53_06260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_06275	COG1570	exodeoxyribonuclease VII activity
IUA53_06280	COG0517	IMP dehydrogenase activity
IUA53_06280	COG0516	GMP reductase activity
IUA53_06295	COG0123	including yeast histone deacetylase and acetoin utilization protein
IUA53_06315	COG1720	tRNA m6t6A37 methyltransferase activity
IUA53_06355	COG0544	peptidyl-prolyl cis-trans isomerase activity
IUA53_06360	COG0740	serine-type endopeptidase activity
IUA53_06365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IUA53_06370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IUA53_06375	COG0776	regulation of translation
IUA53_06380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_06405	COG0268	Binds directly to 16S ribosomal RNA
IUA53_06410	COG0728	peptidoglycan biosynthetic process
IUA53_06415	COG0196	riboflavin kinase activity
IUA53_06420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IUA53_06430	COG1047	Peptidyl-prolyl cis-trans
IUA53_06435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IUA53_06475	COG4795	General secretion pathway protein
IUA53_06515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IUA53_06530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IUA53_06535	COG1595	DNA-templated transcription, initiation
IUA53_06580	COG0084	hydrolase, TatD family'
IUA53_06590	COG0560	Phosphoserine phosphatase
IUA53_06600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IUA53_06610	COG0488	(ABC) transporter
IUA53_06615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUA53_06630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUA53_06630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUA53_06645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IUA53_06660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IUA53_06670	COG0142	geranyltranstransferase activity
IUA53_06680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IUA53_06690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IUA53_06705	COG4221	oxidoreductase activity
IUA53_06720	COG1595	DNA-templated transcription, initiation
IUA53_06735	COG0564	pseudouridine synthase activity
IUA53_06745	COG0542	response to heat
IUA53_06765	COG1183	phosphatidylcholine synthase activity
IUA53_06795	COG5001	Diguanylate cyclase
IUA53_06795	COG2203	Gaf domain
IUA53_06795	COG3706	GGDEF domain
IUA53_06795	COG4251	negative regulation of phosphorylation
IUA53_06805	COG4249	Peptidase C14 caspase catalytic subunit p20
IUA53_06805	COG2319	Wd-40 repeat
IUA53_06815	COG3220	belongs to the UPF0276 family
IUA53_06825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IUA53_06830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IUA53_06850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IUA53_06855	COG0326	Molecular chaperone. Has ATPase activity
IUA53_06880	COG2116	formate transmembrane transporter activity
IUA53_06885	COG0583	DNA-binding transcription factor activity
IUA53_06890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IUA53_06890	COG0140	phosphoribosyl-ATP diphosphatase activity
IUA53_06905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IUA53_06910	COG0131	Imidazoleglycerol-phosphate dehydratase
IUA53_06910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUA53_06915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_06920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IUA53_06935	COG4771	TonB-dependent receptor
IUA53_06940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IUA53_06965	COG1199	ATP-dependent helicase activity
IUA53_06970	COG1214	PFAM Peptidase M22, glycoprotease
IUA53_06985	COG2267	carboxylic ester hydrolase activity
IUA53_06990	COG0318	PFAM AMP-dependent synthetase and ligase
IUA53_06995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IUA53_07010	COG0179	Fumarylacetoacetate (FAA) hydrolase
IUA53_07015	COG2983	Belongs to the UPF0260 family
IUA53_07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IUA53_07025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IUA53_07035	COG2186	Transcriptional regulator
IUA53_07065	COG4399	Belongs to the UPF0754 family
IUA53_07075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IUA53_07100	COG1902	pentaerythritol trinitrate reductase activity
IUA53_07100	COG0446	pyridine nucleotide-disulphide oxidoreductase
IUA53_07120	COG3101	peptidyl-lysine hydroxylation
IUA53_07140	COG0668	transmembrane transport
IUA53_07165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IUA53_07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IUA53_07170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUA53_07180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUA53_07205	COG0285	dihydrofolate synthase activity
IUA53_07210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IUA53_07215	COG1286	toxin biosynthetic process
IUA53_07220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IUA53_07235	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IUA53_07240	COG0583	DNA-binding transcription factor activity
IUA53_07250	COG2268	Band 7 protein
IUA53_07265	COG1785	Belongs to the alkaline phosphatase family
IUA53_07270	COG1785	Belongs to the alkaline phosphatase family
IUA53_07280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUA53_07285	COG0215	cysteine-tRNA ligase activity
IUA53_07295	COG1388	LysM domain
IUA53_07295	COG0741	lytic transglycosylase activity
IUA53_07300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUA53_07305	COG2226	methyltransferase
IUA53_07310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_07310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_07315	COG0489	protein tyrosine kinase activity
IUA53_07325	COG0471	metal ion transport
IUA53_07345	COG0330	HflC and HflK could
IUA53_07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_07385	COG4191	Histidine kinase
IUA53_07390	COG0784	Response regulator, receiver
IUA53_07390	COG3437	response regulator, receiver
IUA53_07400	COG2205	protein histidine kinase activity
IUA53_07405	COG0745	RESPONSE REGULATOR receiver
IUA53_07445	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_07450	COG1609	Transcriptional regulator
IUA53_07465	COG1119	ATPase activity
IUA53_07475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_07480	COG0308	aminopeptidase N
IUA53_07495	COG4677	pectinesterase activity
IUA53_07505	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IUA53_07515	COG2755	lipolytic protein G-D-S-L family
IUA53_07520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUA53_07525	COG0246	Mannitol dehydrogenase
IUA53_07530	COG1904	glucuronate isomerase
IUA53_07535	COG2721	sulfolactate sulfo-lyase activity
IUA53_07560	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IUA53_07565	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_07600	COG0745	RESPONSE REGULATOR receiver
IUA53_07605	COG2205	protein histidine kinase activity
IUA53_07645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IUA53_07650	COG0469	pyruvate kinase activity
IUA53_07655	COG1737	Transcriptional regulator
IUA53_07660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IUA53_07670	COG0129	dihydroxy-acid dehydratase activity
IUA53_07675	COG0837	glucose binding
IUA53_07680	COG0800	Aldolase
IUA53_07685	COG0676	glucose-6-phosphate 1-epimerase activity
IUA53_07695	COG1640	4-alpha-glucanotransferase
IUA53_07700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IUA53_07710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IUA53_07730	COG2866	Carboxypeptidase
IUA53_07735	COG1115	amino acid carrier protein
IUA53_07745	COG3139	Protein of unknown function (DUF1315)
IUA53_07790	COG2205	protein histidine kinase activity
IUA53_07790	COG0784	Response regulator, receiver
IUA53_07795	COG0784	Response regulator, receiver
IUA53_07800	COG4251	negative regulation of phosphorylation
IUA53_07810	COG2204	response regulator
IUA53_07830	COG0640	Transcriptional regulator
IUA53_07840	COG3085	chromosome segregation
IUA53_07850	COG0583	DNA-binding transcription factor activity
IUA53_07865	COG3132	Protein of unknown function, DUF480
IUA53_07880	COG1022	Amp-dependent synthetase and ligase
IUA53_07890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUA53_07895	COG1074	ATP-dependent DNA helicase activity
IUA53_07900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUA53_07925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IUA53_07930	COG3268	Saccharopine dehydrogenase
IUA53_07935	COG0436	Aminotransferase
IUA53_07955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUA53_07960	COG0521	Mo-molybdopterin cofactor biosynthetic process
IUA53_07965	COG0315	cyclic pyranopterin monophosphate synthase activity
IUA53_07970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IUA53_07990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IUA53_07990	COG1618	nucleotide phosphatase activity, acting on free nucleotides
IUA53_08010	COG4771	TonB-dependent receptor
IUA53_08045	COG0596	Alpha beta hydrolase
IUA53_08050	COG1024	Enoyl-CoA hydratase
IUA53_08050	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_08055	COG0183	Belongs to the thiolase family
IUA53_08060	COG1960	acyl-CoA dehydrogenase activity
IUA53_08070	COG2390	Transcriptional regulator
IUA53_08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_08110	COG0668	transmembrane transport
IUA53_08115	COG4771	TonB-dependent receptor
IUA53_08140	COG3437	response regulator, receiver
IUA53_08150	COG0195	Participates in both transcription termination and antitermination
IUA53_08165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IUA53_08175	COG3706	GGDEF domain
IUA53_08180	COG0596	Alpha beta hydrolase
IUA53_08190	COG3153	acetyltransferase
IUA53_08190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_08240	COG0662	Cupin 2, conserved barrel domain protein
IUA53_08270	COG4771	TonB-dependent receptor
IUA53_08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUA53_08285	COG4134	Bacterial extracellular solute-binding protein
IUA53_08290	COG4135	transport system, permease component
IUA53_08295	COG4136	ATPase activity
IUA53_08300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUA53_08310	COG3932	Exopolysaccharide synthesis, ExoD
IUA53_08315	COG0604	alcohol dehydrogenase
IUA53_08350	COG0840	transmembrane signaling receptor activity
IUA53_08370	COG1131	(ABC) transporter
IUA53_08385	COG1902	pentaerythritol trinitrate reductase activity
IUA53_08395	COG2867	negative regulation of translational initiation
IUA53_08400	COG2914	Belongs to the UPF0125 (RnfH) family
IUA53_08410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IUA53_08415	COG4771	TonB-dependent receptor
IUA53_08420	COG0457	Tetratricopeptide repeat
IUA53_08430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUA53_08430	COG0574	Belongs to the PEP-utilizing enzyme family
IUA53_08450	COG0277	FAD linked oxidase domain protein
IUA53_08450	COG0247	lactate metabolic process
IUA53_08460	COG2850	peptidyl-arginine hydroxylation
IUA53_08470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IUA53_08475	COG2915	High frequency lysogenization protein hflD homolog
IUA53_08480	COG0482	sulfurtransferase activity
IUA53_08485	COG1187	pseudouridine synthase activity
IUA53_08495	COG1278	Cold shock
IUA53_08500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IUA53_08505	COG0542	response to heat
IUA53_08510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IUA53_08515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IUA53_08520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IUA53_08525	COG0492	ferredoxin-NADP+ reductase activity
IUA53_08530	COG3092	negative regulation of chromosome organization
IUA53_08535	COG3091	SprT-like family
IUA53_08540	COG0616	signal peptide processing
IUA53_08545	COG0778	Nitroreductase
IUA53_08555	COG0252	asparaginase activity
IUA53_08560	COG3706	GGDEF domain
IUA53_08565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IUA53_08570	COG0321	lipoyl(octanoyl) transferase activity
IUA53_08575	COG2921	Belongs to the UPF0250 family
IUA53_08580	COG1686	Belongs to the peptidase S11 family
IUA53_08585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUA53_08590	COG0772	Belongs to the SEDS family
IUA53_08595	COG0768	penicillin binding
IUA53_08600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IUA53_08605	COG0799	negative regulation of ribosome biogenesis
IUA53_08610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IUA53_08615	COG1466	dna polymerase III delta subunit
IUA53_08620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IUA53_08625	COG0495	leucyl-tRNA aminoacylation
IUA53_08630	COG1067	ATP-dependent peptidase activity
IUA53_08640	COG1534	Rna-binding protein
IUA53_08645	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IUA53_08655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUA53_08660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUA53_08665	COG0149	triose-phosphate isomerase activity
IUA53_08670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IUA53_08680	COG1716	ATPase activity
IUA53_08680	COG5001	Diguanylate cyclase
IUA53_08710	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_08725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_08730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IUA53_08735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IUA53_08750	COG1185	polyribonucleotide nucleotidyltransferase activity
IUA53_08770	COG0295	cytidine deaminase activity
IUA53_08785	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IUA53_08790	COG1196	nuclear chromosome segregation
IUA53_08800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IUA53_08810	COG0658	competence protein
IUA53_08810	COG2333	competence protein COMEC
IUA53_08815	COG1132	(ABC) transporter
IUA53_08820	COG1663	tetraacyldisaccharide 4'-kinase activity
IUA53_08890	COG2808	Putative FMN-binding domain
IUA53_08985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUA53_08990	COG0435	Glutathione S-transferase
IUA53_09015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUA53_09020	COG1053	succinate dehydrogenase
IUA53_09025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUA53_09030	COG0567	Dehydrogenase, E1 component
IUA53_09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUA53_09070	COG4667	esterase of the alpha-beta hydrolase superfamily
IUA53_09085	COG0366	Alpha amylase catalytic
IUA53_09110	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_09115	COG2267	carboxylic ester hydrolase activity
IUA53_09125	COG0616	signal peptide processing
IUA53_09135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IUA53_09140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUA53_09145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IUA53_09150	COG0386	Belongs to the glutathione peroxidase family
IUA53_09155	COG2084	Dehydrogenase
IUA53_09170	COG1960	acyl-CoA dehydrogenase activity
IUA53_09175	COG1024	Enoyl-CoA hydratase
IUA53_09185	COG2226	methyltransferase
IUA53_09190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IUA53_09195	COG3083	sulfuric ester hydrolase activity
IUA53_09200	COG3082	Protein of unknown function (DUF1414)
IUA53_09205	COG3081	Nucleoid-associated protein
IUA53_09235	COG3275	phosphorelay sensor kinase activity
IUA53_09240	COG3279	Response regulator of the LytR AlgR family
IUA53_09245	COG0205	6-phosphofructokinase activity
IUA53_09270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_09270	COG2205	protein histidine kinase activity
IUA53_09280	COG1054	Belongs to the UPF0176 family
IUA53_09300	COG0513	Belongs to the DEAD box helicase family
IUA53_09310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IUA53_09315	COG0583	DNA-binding transcription factor activity
IUA53_09345	COG1760	l-serine dehydratase
IUA53_09370	COG3706	GGDEF domain
IUA53_09380	COG1404	Belongs to the peptidase S8 family
IUA53_09390	COG0022	dehydrogenase e1 component
IUA53_09400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUA53_09405	COG0515	serine threonine protein kinase
IUA53_09410	COG1946	Acyl-CoA thioesterase
IUA53_09420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_09430	COG1956	GAF domain-containing protein
IUA53_09445	COG0793	Belongs to the peptidase S41A family
IUA53_09450	COG0733	neurotransmitter:sodium symporter activity
IUA53_09455	COG1757	Na H antiporter
IUA53_09460	COG0308	aminopeptidase N
IUA53_09495	COG0167	dihydroorotate dehydrogenase activity
IUA53_09510	COG0488	(ABC) transporter
IUA53_09520	COG3130	regulation of translation
IUA53_09525	COG3385	transposase activity
IUA53_09530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUA53_09540	COG0415	Belongs to the DNA photolyase family
IUA53_09545	COG0415	Belongs to the DNA photolyase family
IUA53_09550	COG0415	Belongs to the DNA photolyase family
IUA53_09555	COG3046	protein related to deoxyribodipyrimidine photolyase
IUA53_09625	COG4772	TonB-dependent receptor
IUA53_09680	COG0789	Transcriptional regulator
IUA53_09710	COG2132	Multicopper oxidase
IUA53_09715	COG3667	copper resistance
IUA53_09730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_09770	COG2217	Heavy metal translocating P-type atpase
IUA53_09775	COG0789	Transcriptional regulator
IUA53_09860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_09890	COG0745	RESPONSE REGULATOR receiver
IUA53_09895	COG5002	protein histidine kinase activity
IUA53_09955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUA53_09960	COG0589	response to stress
IUA53_09970	COG0069	glutamate synthase activity
IUA53_09985	COG2193	ferroxidase activity
IUA53_09995	COG3278	Belongs to the heme-copper respiratory oxidase family
IUA53_10010	COG2010	Cytochrome c
IUA53_10035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUA53_10040	COG0589	response to stress
IUA53_10045	COG0037	tRNA processing
IUA53_10050	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUA53_10070	COG1280	lysine exporter protein (LysE YggA)
IUA53_10080	COG2897	thiosulfate sulfurtransferase activity
IUA53_10085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IUA53_10090	COG3148	PFAM DTW domain containing protein
IUA53_10140	COG0582	viral genome integration into host DNA
IUA53_10165	COG0322	excinuclease ABC activity
IUA53_10170	COG2197	response regulator
IUA53_10175	COG1741	Belongs to the pirin family
IUA53_10180	COG0436	Aminotransferase
IUA53_10185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IUA53_10195	COG3384	dioxygenase
IUA53_10200	COG2259	Doxx family
IUA53_10205	COG0583	DNA-binding transcription factor activity
IUA53_10220	COG0670	Belongs to the BI1 family
IUA53_10225	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IUA53_10240	COG2920	part of a sulfur-relay system
IUA53_10245	COG0561	phosphatase activity
IUA53_10275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUA53_10280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IUA53_10285	COG0531	amino acid
IUA53_10285	COG1674	ftsk spoiiie
IUA53_10295	COG0686	Belongs to the AlaDH PNT family
IUA53_10300	COG0284	orotidine-5'-phosphate decarboxylase activity
IUA53_10305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUA53_10320	COG0776	regulation of translation
IUA53_10325	COG0539	negative regulation of cytoplasmic translation
IUA53_10330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IUA53_10335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IUA53_10340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IUA53_10355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUA53_10360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUA53_10365	COG0633	Ferredoxin
IUA53_10405	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IUA53_10410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IUA53_10420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUA53_10435	COG4783	chaperone-mediated protein folding
IUA53_10440	COG4232	protein-disulfide reductase activity
IUA53_10445	COG1393	Belongs to the ArsC family
IUA53_10465	COG0789	Transcriptional regulator
IUA53_10495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IUA53_10510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUA53_10520	COG1960	acyl-CoA dehydrogenase activity
IUA53_10545	COG3769	mannosylglycerate metabolic process
IUA53_10550	COG1215	transferase activity, transferring glycosyl groups
IUA53_10565	COG0303	'Molybdopterin
IUA53_10570	COG0534	Mate efflux family protein
IUA53_10585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUA53_10590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUA53_10610	COG0405	Gamma-glutamyltransferase
IUA53_10615	COG1024	Enoyl-CoA hydratase
IUA53_10655	COG1448	Aminotransferase
IUA53_10665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IUA53_10675	COG1671	Belongs to the UPF0178 family
IUA53_10680	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_10685	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_10690	COG1960	acyl-CoA dehydrogenase activity
IUA53_10695	COG4977	sequence-specific DNA binding
IUA53_10745	COG0596	Alpha beta hydrolase
IUA53_10755	COG0716	FMN binding
IUA53_10765	COG0735	belongs to the Fur family
IUA53_10775	COG1984	allophanate hydrolase subunit 2
IUA53_10785	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IUA53_10790	COG2996	Protein conserved in bacteria
IUA53_10795	COG1765	OsmC-like protein
IUA53_10810	COG0436	Aminotransferase
IUA53_10815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IUA53_10835	COG4771	TonB-dependent receptor
IUA53_10840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IUA53_10850	COG1238	metal cluster binding
IUA53_10860	COG3012	SEC-C Motif Domain Protein
IUA53_10875	COG0456	acetyltransferase
IUA53_10880	COG3706	GGDEF domain
IUA53_10885	COG0702	epimerase
IUA53_10895	COG0084	hydrolase, TatD family'
IUA53_10910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUA53_10915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUA53_10920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUA53_10925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUA53_10940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUA53_10945	COG0416	fatty acid biosynthetic process
IUA53_10955	COG1399	metal-binding, possibly nucleic acid-binding protein
IUA53_10965	COG0546	phosphoglycolate phosphatase activity
IUA53_10970	COG0564	pseudouridine synthase activity
IUA53_10975	COG1530	ribonuclease E activity
IUA53_10990	COG2153	protein acetylation
IUA53_10995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUA53_11000	COG3122	Protein conserved in bacteria
IUA53_11005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IUA53_11010	COG3724	N-succinylarginine dihydrolase activity
IUA53_11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUA53_11030	COG1136	(ABC) transporter
IUA53_11035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IUA53_11070	COG0328	RNA-DNA hybrid ribonuclease activity
IUA53_11075	COG3321	synthase
IUA53_11075	COG0604	alcohol dehydrogenase
IUA53_11095	COG1643	Atp-dependent helicase
IUA53_11135	COG2925	Exonuclease
IUA53_11150	COG0183	Belongs to the thiolase family
IUA53_11155	COG0789	Transcriptional regulator
IUA53_11160	COG1960	acyl-CoA dehydrogenase activity
IUA53_11165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IUA53_11175	COG4770	biotin carboxylase activity
IUA53_11205	COG2814	Major facilitator Superfamily
IUA53_11240	COG0708	Exodeoxyribonuclease III
IUA53_11250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IUA53_11255	COG4591	ABC-type transport system involved in lipoprotein release permease component
IUA53_11265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUA53_11275	COG2096	Adenosyltransferase
IUA53_11280	COG1472	Belongs to the glycosyl hydrolase 3 family
IUA53_11305	COG0072	phenylalanine-tRNA ligase activity
IUA53_11305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IUA53_11315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_11315	COG2755	lipolytic protein G-D-S-L family
IUA53_11355	COG0438	transferase activity, transferring glycosyl groups
IUA53_11370	COG2755	lipolytic protein G-D-S-L family
IUA53_11370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IUA53_11395	COG3300	MHYT domain
IUA53_11395	COG5001	Diguanylate cyclase
IUA53_11410	COG0438	transferase activity, transferring glycosyl groups
IUA53_11425	COG0489	protein tyrosine kinase activity
IUA53_11430	COG1596	polysaccharide export
IUA53_11440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUA53_11455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IUA53_11465	COG3001	Fructosamine kinase
IUA53_11470	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_11510	COG0730	response to heat
IUA53_11515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_11535	COG2233	PERMEase
IUA53_11560	COG2205	protein histidine kinase activity
IUA53_11560	COG0784	Response regulator, receiver
IUA53_11570	COG3300	MHYT domain
IUA53_11570	COG5001	Diguanylate cyclase
IUA53_11580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IUA53_11585	COG2252	PERMEase
IUA53_11600	COG1309	transcriptional regulator
IUA53_11610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IUA53_11625	COG2351	hydroxyisourate hydrolase activity
IUA53_11630	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_11640	COG5001	Diguanylate cyclase
IUA53_11640	COG5002	protein histidine kinase activity
IUA53_11640	COG3447	MASE1 domain protein
IUA53_11665	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IUA53_11690	COG1393	Belongs to the ArsC family
IUA53_11720	COG2988	succinylglutamate desuccinylase activity
IUA53_11730	COG0058	SHG alpha-glucan phosphorylase activity
IUA53_11735	COG0033	Phosphoglucomutase
IUA53_11740	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IUA53_11745	COG2116	formate transmembrane transporter activity
IUA53_11750	COG0515	serine threonine protein kinase
IUA53_11750	COG2815	serine threonine protein kinase
IUA53_11755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IUA53_11765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IUA53_11775	COG2363	Small membrane protein
IUA53_11785	COG0583	DNA-binding transcription factor activity
IUA53_11795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IUA53_11805	COG3437	response regulator, receiver
IUA53_11805	COG0784	Response regulator, receiver
IUA53_11810	COG2890	protein-(glutamine-N5) methyltransferase activity
IUA53_11820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IUA53_11825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IUA53_11830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IUA53_11840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IUA53_11865	COG0012	GTP binding
IUA53_11925	COG1115	amino acid carrier protein
IUA53_11930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IUA53_11935	COG1607	acyl-coa hydrolase
IUA53_11960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUA53_11970	COG1702	phosphate starvation-inducible protein PhoH
IUA53_11990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IUA53_11995	COG4535	Mg2 and Co2 transporter CorC
IUA53_12000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IUA53_12005	COG0857	belongs to the CobB CobQ family
IUA53_12005	COG0280	phosphate acetyltransferase
IUA53_12015	COG0071	Belongs to the small heat shock protein (HSP20) family
IUA53_12025	COG0840	transmembrane signaling receptor activity
IUA53_12030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUA53_12035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IUA53_12045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IUA53_12055	COG5001	Diguanylate cyclase
IUA53_12055	COG3300	MHYT domain
IUA53_12060	COG3909	cytochrome
IUA53_12065	COG0484	heat shock protein binding
IUA53_12075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IUA53_12080	COG2205	protein histidine kinase activity
IUA53_12080	COG2202	Pas domain
IUA53_12095	COG4771	TonB-dependent receptor
IUA53_12100	COG2610	gluconate transmembrane transporter activity
IUA53_12105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IUA53_12115	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_12120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IUA53_12125	COG0783	Belongs to the Dps family
IUA53_12135	COG0497	DNA recombination
IUA53_12140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUA53_12145	COG0500	methyltransferase
IUA53_12150	COG2733	membrane
IUA53_12165	COG0110	maltose O-acetyltransferase activity
IUA53_12170	COG0656	L-ascorbic acid biosynthetic process
IUA53_12180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IUA53_12185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IUA53_12190	COG0009	L-threonylcarbamoyladenylate synthase
IUA53_12195	COG0613	PHP domain protein
IUA53_12200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUA53_12210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUA53_12215	COG0134	indole-3-glycerol-phosphate synthase activity
IUA53_12215	COG0135	phosphoribosylanthranilate isomerase activity
IUA53_12225	COG0159	tryptophan synthase activity
IUA53_12230	COG2350	Protein conserved in bacteria
IUA53_12255	COG0628	permease
IUA53_12260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUA53_12265	COG1090	epimerase
IUA53_12270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IUA53_12275	COG4181	ATPase activity
IUA53_12280	COG2755	lipolytic protein G-D-S-L family
IUA53_12300	COG0402	S-adenosylhomocysteine deaminase activity
IUA53_12305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_12350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IUA53_12380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IUA53_12385	COG5265	(ABC) transporter
IUA53_12400	COG2972	Histidine kinase
IUA53_12405	COG1131	(ABC) transporter
IUA53_12415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IUA53_12420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUA53_12425	COG3340	Belongs to the peptidase S51 family
IUA53_12435	COG1073	alpha beta
IUA53_12435	COG2226	methyltransferase
IUA53_12470	COG0189	ligase activity
IUA53_12485	COG0017	Asparaginyl-tRNA synthetase
IUA53_12490	COG1505	serine-type exopeptidase activity
IUA53_12500	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IUA53_12520	COG3093	addiction module antidote protein HigA
IUA53_12540	COG2995	paraquat-inducible protein a
IUA53_12545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUA53_12545	COG3008	intermembrane lipid transfer
IUA53_12590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IUA53_12590	COG3321	synthase
IUA53_12590	COG0604	alcohol dehydrogenase
IUA53_12590	COG4221	oxidoreductase activity
IUA53_12595	COG0583	DNA-binding transcription factor activity
IUA53_12600	COG3038	cytochrome b561
IUA53_12605	COG0753	catalase activity
IUA53_12610	COG4221	oxidoreductase activity
IUA53_12615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_12635	COG0612	Peptidase, M16
IUA53_12640	COG4667	esterase of the alpha-beta hydrolase superfamily
IUA53_12645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_12675	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_12685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IUA53_12715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IUA53_12720	COG2885	chlorophyll binding
IUA53_12725	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_12740	COG0811	peptide transport
IUA53_12745	COG0824	Thioesterase
IUA53_12750	COG2255	four-way junction helicase activity
IUA53_12755	COG0632	four-way junction helicase activity
IUA53_12760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IUA53_12765	COG0494	nUDIX hydrolase
IUA53_12770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IUA53_12775	COG1801	Protein of unknown function DUF72
IUA53_12780	COG2204	response regulator
IUA53_12790	COG2205	protein histidine kinase activity
IUA53_12820	COG0023	Translation Initiation Factor
IUA53_12825	COG0745	RESPONSE REGULATOR receiver
IUA53_12830	COG0077	Prephenate dehydratase
IUA53_12830	COG1605	Chorismate mutase
IUA53_12835	COG1605	Chorismate mutase
IUA53_12835	COG0287	Prephenate dehydrogenase
IUA53_12840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUA53_12850	COG2860	membrane
IUA53_12855	COG0335	large ribosomal subunit rRNA binding
IUA53_12860	COG0336	Belongs to the RNA methyltransferase TrmD family
IUA53_12865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IUA53_12870	COG0228	four-way junction DNA binding
IUA53_12885	COG2873	o-acetylhomoserine
IUA53_12890	COG1132	(ABC) transporter
IUA53_12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_12935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUA53_12940	COG4137	Cytochrome C assembly protein
IUA53_12945	COG4536	flavin adenine dinucleotide binding
IUA53_12955	COG2062	phosphohistidine phosphatase, SixA
IUA53_12960	COG1025	Belongs to the peptidase M16 family
IUA53_12980	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_12980	COG1024	Enoyl-CoA hydratase
IUA53_12990	COG0714	Associated with various cellular activities
IUA53_13010	COG2304	oxidoreductase activity
IUA53_13025	COG1595	DNA-templated transcription, initiation
IUA53_13040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_13045	COG0175	sulfate reduction
IUA53_13050	COG0529	Catalyzes the synthesis of activated sulfate
IUA53_13065	COG3273	potassium ion transport
IUA53_13065	COG0471	metal ion transport
IUA53_13090	COG0367	asparagine synthase
IUA53_13100	COG0602	queuosine metabolic process
IUA53_13125	COG0556	nucleotide-excision repair
IUA53_13130	COG0534	Mate efflux family protein
IUA53_13145	COG4657	Part of a membrane complex involved in electron transport
IUA53_13150	COG2878	Part of a membrane complex involved in electron transport
IUA53_13155	COG4656	Part of a membrane complex involved in electron transport
IUA53_13160	COG4658	electron transport chain
IUA53_13165	COG4659	FMN binding
IUA53_13170	COG4660	Part of a membrane complex involved in electron transport
IUA53_13175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUA53_13180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_13190	COG0583	DNA-binding transcription factor activity
IUA53_13230	COG3547	Transposase (IS116 IS110 IS902 family)
IUA53_13270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_13320	COG3710	Transcriptional regulator
IUA53_13335	COG3706	GGDEF domain
IUA53_13340	COG1278	Cold shock
IUA53_13345	COG0346	lactoylglutathione lyase activity
IUA53_13350	COG0584	glycerophosphoryl diester phosphodiesterase
IUA53_13355	COG2885	chlorophyll binding
IUA53_13360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUA53_13385	COG4771	TonB-dependent receptor
IUA53_13390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUA53_13395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUA53_13400	COG2766	serine protein kinase
IUA53_13405	COG2718	Belongs to the UPF0229 family
IUA53_13410	COG2719	SpoVR family
IUA53_13430	COG2890	protein-(glutamine-N5) methyltransferase activity
IUA53_13435	COG2840	Smr protein MutS2
IUA53_13455	COG1136	(ABC) transporter
IUA53_13455	COG0577	efflux transmembrane transporter activity
IUA53_13465	COG1136	(ABC) transporter
IUA53_13470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUA53_13480	COG2918	glutathione biosynthetic process
IUA53_13485	COG0612	Peptidase, M16
IUA53_13495	COG0564	pseudouridine synthase activity
IUA53_13500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IUA53_13505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IUA53_13515	COG0572	uridine kinase
IUA53_13555	COG1196	nuclear chromosome segregation
IUA53_13565	COG0543	2 iron, 2 sulfur cluster binding
IUA53_13565	COG0633	Ferredoxin
IUA53_13585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUA53_13680	COG0583	DNA-binding transcription factor activity
IUA53_13700	COG2003	Belongs to the UPF0758 family
IUA53_13725	COG0714	Associated with various cellular activities
IUA53_13745	COG0629	single-stranded DNA binding
IUA53_13760	COG0464	growth
IUA53_13765	COG1404	Belongs to the peptidase S8 family
IUA53_13775	COG1074	ATP-dependent DNA helicase activity
IUA53_13795	COG0681	Belongs to the peptidase S26 family
IUA53_13810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_13830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_13885	COG1230	cation diffusion facilitator family transporter
IUA53_13895	COG0640	Transcriptional regulator
IUA53_13905	COG0789	Transcriptional regulator
IUA53_13915	COG0789	Transcriptional regulator
IUA53_13960	COG1484	DNA-dependent DNA replication
IUA53_14065	COG3474	cytochrome
IUA53_14075	COG4771	TonB-dependent receptor
IUA53_14090	COG3119	arylsulfatase activity
IUA53_14095	COG2814	Major facilitator Superfamily
IUA53_14100	COG1404	Belongs to the peptidase S8 family
IUA53_14105	COG1132	(ABC) transporter
IUA53_14120	COG0318	PFAM AMP-dependent synthetase and ligase
IUA53_14145	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_14165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUA53_14295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IUA53_14320	COG1484	DNA-dependent DNA replication
IUA53_14325	COG4584	PFAM Integrase catalytic
IUA53_14360	COG4584	PFAM Integrase catalytic
IUA53_14370	COG0668	transmembrane transport
IUA53_14405	COG3550	peptidyl-serine autophosphorylation
IUA53_14410	COG3620	sequence-specific DNA binding
IUA53_14420	COG3706	GGDEF domain
IUA53_14430	COG2814	Major facilitator Superfamily
IUA53_14435	COG0583	DNA-binding transcription factor activity
IUA53_14450	COG0456	acetyltransferase
IUA53_14490	COG1444	tRNA N-acetyltransferase activity
IUA53_14505	COG0848	biopolymer transport protein
IUA53_14510	COG0811	peptide transport
IUA53_14515	COG0811	peptide transport
IUA53_14550	COG1522	sequence-specific DNA binding
IUA53_14555	COG0625	glutathione transferase activity
IUA53_14585	COG1842	Phage shock protein A
IUA53_14590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IUA53_14595	COG0747	negative chemotaxis
IUA53_14600	COG0601	transmembrane transport
IUA53_14605	COG4171	peptide transport system, permease
IUA53_14610	COG4172	Belongs to the ABC transporter superfamily
IUA53_14615	COG4172	Belongs to the ABC transporter superfamily
IUA53_14620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IUA53_14655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IUA53_14660	COG2137	regulation of response to DNA damage stimulus
IUA53_14675	COG0659	secondary active sulfate transmembrane transporter activity
IUA53_14680	COG0288	reversible hydration of carbon dioxide
IUA53_14685	COG0583	DNA-binding transcription factor activity
IUA53_14690	COG0583	DNA-binding transcription factor activity
IUA53_14695	COG3123	guanosine phosphorylase activity
IUA53_14710	COG1410	methionine synthase
IUA53_14710	COG0646	methionine synthase
IUA53_14715	COG1410	methionine synthase
IUA53_14715	COG0646	methionine synthase
IUA53_14730	COG0835	chemotaxis
IUA53_14740	COG1192	Involved in chromosome partitioning
IUA53_14745	COG2201	protein-glutamate methylesterase activity
IUA53_14750	COG2198	Histidine kinase
IUA53_14750	COG0784	Response regulator, receiver
IUA53_14750	COG0643	Histidine kinase
IUA53_14755	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IUA53_14780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IUA53_14795	COG1987	bacterial-type flagellum assembly
IUA53_14855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IUA53_14860	COG1766	The M ring may be actively involved in energy transduction
IUA53_14865	COG1677	Flagellar hook-basal body complex protein FliE
IUA53_14895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IUA53_14935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IUA53_14940	COG3475	LICD family
IUA53_14945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IUA53_14950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUA53_15005	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_15025	COG2089	acid synthase
IUA53_15030	COG1083	cytidylyl-transferase
IUA53_15035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IUA53_15040	COG1086	Polysaccharide biosynthesis protein
IUA53_15050	COG1516	flagellar protein fliS
IUA53_15060	COG1334	flagellar protein FlaG
IUA53_15065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_15070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IUA53_15090	COG1256	bacterial-type flagellum assembly
IUA53_15095	COG3951	Flagellar rod assembly protein muramidase FlgJ
IUA53_15095	COG1705	Flagellar rod assembly protein muramidase FlgJ
IUA53_15115	COG4787	bacterial-type flagellum-dependent cell motility
IUA53_15135	COG1815	bacterial-type flagellum-dependent cell motility
IUA53_15140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IUA53_15145	COG0784	Response regulator, receiver
IUA53_15145	COG0835	chemotaxis
IUA53_15180	COG2840	Smr protein MutS2
IUA53_15190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IUA53_15190	COG0047	phosphoribosylformylglycinamidine synthase activity
IUA53_15220	COG0037	tRNA processing
IUA53_15225	COG0825	malonyl-CoA metabolic process
IUA53_15230	COG0587	DNA-directed DNA polymerase activity
IUA53_15245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IUA53_15250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUA53_15265	COG0750	zinc metalloprotease
IUA53_15275	COG0575	Belongs to the CDS family
IUA53_15280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IUA53_15290	COG0528	UMP kinase activity
IUA53_15300	COG0052	Belongs to the universal ribosomal protein uS2 family
IUA53_15305	COG0024	Methionine aminopeptidase
IUA53_15310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IUA53_15325	COG0564	pseudouridine synthase activity
IUA53_15385	COG1484	DNA-dependent DNA replication
IUA53_15415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUA53_15415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IUA53_15425	COG1611	Belongs to the LOG family
IUA53_15440	COG0473	3-isopropylmalate dehydrogenase activity
IUA53_15445	COG1555	photosystem II stabilization
IUA53_15445	COG1596	polysaccharide export
IUA53_15450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUA53_15465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IUA53_15505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IUA53_15510	COG2853	Lipoprotein
IUA53_15525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUA53_15530	COG1138	Cytochrome C-type biogenesis protein
IUA53_15540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_15545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_15550	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IUA53_15555	COG4133	protoheme IX ABC transporter activity
IUA53_15570	COG1668	transmembrane transport
IUA53_15575	COG4555	ABC transporter
IUA53_15595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IUA53_15620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IUA53_15625	COG0473	3-isopropylmalate dehydrogenase activity
IUA53_15635	COG0066	3-isopropylmalate dehydratase activity
IUA53_15650	COG3267	Type II secretory pathway component ExeA
IUA53_15650	COG3409	Peptidoglycan-binding domain 1 protein
IUA53_15660	COG0513	Belongs to the DEAD box helicase family
IUA53_15665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IUA53_15670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUA53_15700	COG1346	cytolysis
IUA53_15705	COG1380	Effector of murein hydrolase LrgA
IUA53_15780	COG0840	transmembrane signaling receptor activity
IUA53_15785	COG3588	fructose-bisphosphate aldolase
IUA53_15815	COG3842	ATPase activity
IUA53_15820	COG3842	ATPase activity
IUA53_15825	COG3284	Transcriptional regulator
IUA53_15830	COG0149	triose-phosphate isomerase activity
IUA53_15835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IUA53_15840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IUA53_15850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IUA53_15855	COG3842	ATPase activity
IUA53_15905	COG0668	transmembrane transport
IUA53_15910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUA53_15925	COG0488	(ABC) transporter
IUA53_15935	COG2971	BadF BadG BcrA BcrD
IUA53_15955	COG0625	glutathione transferase activity
IUA53_16010	COG2801	Transposase and inactivated derivatives
IUA53_16015	COG2801	Transposase and inactivated derivatives
IUA53_16020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IUA53_16030	COG0419	ATPase involved in DNA repair
IUA53_16035	COG0420	3'-5' exonuclease activity
IUA53_16045	COG1739	Uncharacterized protein family UPF0029
IUA53_16055	COG1764	response to oxidative stress
IUA53_16060	COG1846	Transcriptional regulator
IUA53_16065	COG1272	protein, Hemolysin III
IUA53_16075	COG0583	DNA-binding transcription factor activity
IUA53_16080	COG0589	response to stress
IUA53_16085	COG0306	phosphate transporter
IUA53_16095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IUA53_16105	COG0573	inorganic phosphate transmembrane transporter activity
IUA53_16115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IUA53_16120	COG0248	Ppx GppA phosphatase
IUA53_16125	COG3588	fructose-bisphosphate aldolase
IUA53_16130	COG0126	phosphoglycerate kinase activity
IUA53_16140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUA53_16165	COG1979	alcohol dehydrogenase
IUA53_16180	COG0784	Response regulator, receiver
IUA53_16180	COG2205	protein histidine kinase activity
IUA53_16195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUA53_16245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUA53_16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUA53_16260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUA53_16275	COG5007	Belongs to the BolA IbaG family
IUA53_16285	COG2854	intermembrane phospholipid transfer
IUA53_16290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUA53_16295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUA53_16300	COG1127	ABC transporter
IUA53_16315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUA53_16330	COG1137	ATPase activity
IUA53_16335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IUA53_16355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IUA53_16360	COG2239	Acts as a magnesium transporter
IUA53_16365	COG0745	RESPONSE REGULATOR receiver
IUA53_16380	COG2969	positive regulation of protein catabolic process
IUA53_16385	COG0625	glutathione transferase activity
IUA53_16390	COG2857	Cytochrome c1
IUA53_16395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUA53_16400	COG0723	plastoquinol--plastocyanin reductase activity
IUA53_16410	COG4206	TonB-dependent receptor
IUA53_16420	COG1595	DNA-templated transcription, initiation
IUA53_16425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IUA53_16440	COG3956	TIGRFAM MazG family protein
IUA53_16445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUA53_16450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IUA53_16460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IUA53_16475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUA53_16480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_16490	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IUA53_16500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IUA53_16505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_16510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IUA53_16515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IUA53_16520	COG2967	ApaG domain
IUA53_16525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IUA53_16530	COG0840	transmembrane signaling receptor activity
IUA53_16535	COG0527	aspartate kinase activity
IUA53_16550	COG1793	dna ligase
IUA53_16560	COG1049	propionate catabolic process, 2-methylcitrate cycle
IUA53_16565	COG2133	pyrroloquinoline quinone binding
IUA53_16580	COG0784	Response regulator, receiver
IUA53_16580	COG5002	protein histidine kinase activity
IUA53_16580	COG2205	protein histidine kinase activity
IUA53_16585	COG3437	response regulator, receiver
IUA53_16590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IUA53_16600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IUA53_16605	COG0848	biopolymer transport protein
IUA53_16610	COG0811	peptide transport
IUA53_16615	COG0811	peptide transport
IUA53_16645	COG5002	protein histidine kinase activity
IUA53_16650	COG0745	RESPONSE REGULATOR receiver
IUA53_16655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IUA53_16655	COG4191	Histidine kinase
IUA53_16660	COG2974	May be involved in recombination
IUA53_16665	COG1396	sequence-specific DNA binding
IUA53_16670	COG3135	benzoate transporter
IUA53_16685	COG0537	adenosine 5'-monophosphoramidase activity
IUA53_16705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IUA53_16725	COG0358	DNA primase activity
IUA53_16760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUA53_16780	COG4948	Mandelate Racemase Muconate Lactonizing
IUA53_16790	COG1028	Short-chain dehydrogenase reductase Sdr
IUA53_16795	COG1960	acyl-CoA dehydrogenase activity
IUA53_16810	COG0348	domain, Protein
IUA53_16815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IUA53_16820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUA53_16830	COG0746	molybdenum cofactor guanylyltransferase activity
IUA53_16840	COG1116	anion transmembrane transporter activity
IUA53_16845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IUA53_16850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IUA53_16850	COG1116	anion transmembrane transporter activity
IUA53_16860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IUA53_16865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUA53_16865	COG1648	precorrin-2 dehydrogenase activity
IUA53_16870	COG0243	molybdopterin cofactor binding
IUA53_16875	COG2146	nitrite reductase [NAD(P)H] activity
IUA53_16880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IUA53_16885	COG0659	secondary active sulfate transmembrane transporter activity
IUA53_16895	COG3707	response regulator
IUA53_16905	COG0671	phosphoesterase, PA-phosphatase related
IUA53_16910	COG0271	Belongs to the BolA IbaG family
IUA53_16925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUA53_16940	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUA53_16945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IUA53_16950	COG1509	lysine 2,3-aminomutase activity
IUA53_16970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUA53_16975	COG4251	negative regulation of phosphorylation
IUA53_16985	COG0187	DNA topoisomerase II activity
IUA53_16990	COG3150	esterase
IUA53_17000	COG3151	Protein conserved in bacteria
IUA53_17005	COG0494	nUDIX hydrolase
IUA53_17010	COG1538	Outer membrane efflux protein
IUA53_17035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IUA53_17035	COG1648	precorrin-2 dehydrogenase activity
IUA53_17045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IUA53_17055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IUA53_17060	COG0564	pseudouridine synthase activity
IUA53_17080	COG0784	Response regulator, receiver
IUA53_17080	COG2205	protein histidine kinase activity
IUA53_17085	COG3706	GGDEF domain
IUA53_17095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IUA53_17100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IUA53_17105	COG0730	response to heat
IUA53_17115	COG0494	nUDIX hydrolase
IUA53_17120	COG3066	DNA modification
IUA53_17130	COG3025	triphosphatase activity
IUA53_17160	COG1538	Outer membrane efflux protein
IUA53_17170	COG0840	transmembrane signaling receptor activity
IUA53_17180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IUA53_17195	COG0585	pseudouridine synthase activity
IUA53_17200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IUA53_17210	COG1238	metal cluster binding
IUA53_17215	COG4942	peptidase
IUA53_17215	COG1388	LysM domain
IUA53_17220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IUA53_17270	COG0142	geranyltranstransferase activity
IUA53_17280	COG0006	proline dipeptidase activity
IUA53_17285	COG0741	lytic transglycosylase activity
IUA53_17290	COG1024	Enoyl-CoA hydratase
IUA53_17290	COG1250	3-hydroxyacyl-CoA dehydrogenase
IUA53_17295	COG0183	Belongs to the thiolase family
IUA53_17385	COG1228	amidohydrolase
IUA53_17425	COG0519	Catalyzes the synthesis of GMP from XMP
IUA53_17530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IUA53_17535	COG3876	Protein conserved in bacteria
IUA53_17550	COG1757	Na H antiporter
IUA53_17560	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_17570	COG3118	belongs to the thioredoxin family
IUA53_17580	COG0823	Involved in the tonB-independent uptake of proteins
IUA53_17580	COG1506	peptidase
IUA53_17580	COG4946	Tricorn protease homolog
IUA53_17585	COG2133	pyrroloquinoline quinone binding
IUA53_17590	COG0783	Belongs to the Dps family
IUA53_17605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IUA53_17610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IUA53_17615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IUA53_17620	COG2205	protein histidine kinase activity
IUA53_17620	COG0784	Response regulator, receiver
IUA53_17625	COG1473	amidohydrolase
IUA53_17630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IUA53_17635	COG3118	belongs to the thioredoxin family
IUA53_17640	COG0513	Belongs to the DEAD box helicase family
IUA53_17645	COG0248	Ppx GppA phosphatase
IUA53_17655	COG3706	GGDEF domain
IUA53_17670	COG0805	protein transport
IUA53_17675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IUA53_17695	COG0028	Belongs to the TPP enzyme family
IUA53_17725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IUA53_17730	COG1162	GTPase activity
IUA53_17755	COG2861	carbohydrate metabolic process
IUA53_17765	COG4942	peptidase
IUA53_17770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUA53_17775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IUA53_17785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IUA53_17795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUA53_17800	COG2267	carboxylic ester hydrolase activity
IUA53_17805	COG2205	protein histidine kinase activity
IUA53_17810	COG0745	RESPONSE REGULATOR receiver
IUA53_17825	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IUA53_17835	COG1803	Methylglyoxal synthase
IUA53_17855	COG0137	argininosuccinate synthase activity
IUA53_17865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IUA53_17865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IUA53_17870	COG5001	Diguanylate cyclase
IUA53_17870	COG3300	MHYT domain
IUA53_17890	COG0753	catalase activity
IUA53_17895	COG0625	glutathione transferase activity
IUA53_17900	COG0281	malic enzyme
IUA53_17905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IUA53_17940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IUA53_17950	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IUA53_17970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IUA53_17975	COG0180	Tryptophanyl-tRNA synthetase
IUA53_17980	COG0512	Glutamine amidotransferase of anthranilate synthase
IUA53_17990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IUA53_18000	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_18010	COG3300	MHYT domain
IUA53_18010	COG5001	Diguanylate cyclase
IUA53_18050	COG0540	Belongs to the ATCase OTCase family
IUA53_18060	COG2837	iron assimilation
IUA53_18065	COG0405	Gamma-glutamyltransferase
IUA53_18070	COG0004	ammonium transporteR
IUA53_18090	COG2169	Transcriptional regulator
IUA53_18095	COG2354	Protein conserved in bacteria
IUA53_18105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUA53_18115	COG2951	lytic endotransglycosylase activity
IUA53_18120	COG1643	Atp-dependent helicase
IUA53_18135	COG0788	formyltetrahydrofolate deformylase activity
IUA53_18170	COG1519	Transferase
IUA53_18180	COG0438	transferase activity, transferring glycosyl groups
IUA53_18185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IUA53_18200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IUA53_18210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IUA53_18220	COG0089	rRNA binding
IUA53_18235	COG0051	transcription antitermination factor activity, RNA binding
IUA53_18240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUA53_18295	COG0302	gtp cyclohydrolase
IUA53_18305	COG2957	Belongs to the agmatine deiminase family
IUA53_18310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IUA53_18320	COG3706	GGDEF domain
IUA53_18330	COG2207	Transcriptional regulator
IUA53_18335	COG1073	alpha beta
IUA53_18385	COG1201	RNA secondary structure unwinding
IUA53_18395	COG1793	dna ligase
IUA53_18415	COG0625	glutathione transferase activity
IUA53_18425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IUA53_18435	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_18440	COG0028	Belongs to the TPP enzyme family
IUA53_18450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IUA53_18465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IUA53_18470	COG0330	HflC and HflK could
IUA53_18475	COG0330	HflC and HflK could
IUA53_18480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUA53_18485	COG1923	regulation of RNA biosynthetic process
IUA53_18490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IUA53_18495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IUA53_18505	COG0802	atpase or kinase
IUA53_18510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUA53_18510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUA53_18515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUA53_18535	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IUA53_18540	COG0735	belongs to the Fur family
IUA53_18550	COG0432	Pfam Uncharacterised protein family UPF0047
IUA53_18560	COG0305	Participates in initiation and elongation during chromosome replication
IUA53_18585	COG2258	MOSC domain
IUA53_18615	COG0840	transmembrane signaling receptor activity
IUA53_18620	COG4191	Histidine kinase
IUA53_18630	COG1609	Transcriptional regulator
IUA53_18635	COG2211	Major facilitator Superfamily
IUA53_18640	COG2723	6-phospho-beta-galactosidase activity
IUA53_18655	COG0789	Transcriptional regulator
IUA53_18660	COG0655	NAD(P)H dehydrogenase (quinone) activity
IUA53_18670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IUA53_18675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IUA53_18680	COG4558	Periplasmic binding protein
IUA53_18690	COG4771	TonB-dependent receptor
IUA53_18715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IUA53_18720	COG4988	ABC transporter
IUA53_18725	COG4890	Cyd operon protein YbgT
IUA53_18730	COG1294	oxidase, subunit
IUA53_18745	COG2204	response regulator
IUA53_18790	COG1136	(ABC) transporter
IUA53_18830	COG2814	Major facilitator Superfamily
IUA53_18840	COG3237	CsbD-like
IUA53_18855	COG4771	TonB-dependent receptor
IUA53_18860	COG0457	Tetratricopeptide repeat
IUA53_18875	COG3314	Sporulation integral membrane protein YlbJ
IUA53_18880	COG4638	Rieske (2fe-2S)
IUA53_18890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IUA53_18940	COG1595	DNA-templated transcription, initiation
IUA53_18970	COG2267	carboxylic ester hydrolase activity
IUA53_18990	COG1252	NADH dehydrogenase
IUA53_19010	COG0583	DNA-binding transcription factor activity
IUA53_19015	COG2067	long-chain fatty acid transport protein
IUA53_19020	COG2130	NADP-dependent
IUA53_19030	COG0784	Response regulator, receiver
IUA53_19030	COG2205	protein histidine kinase activity
IUA53_19040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_19050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUA53_19055	COG4771	TonB-dependent receptor
IUA53_19060	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IUA53_19080	COG0656	L-ascorbic acid biosynthetic process
IUA53_19085	COG2175	clavaminate synthase activity
IUA53_19090	COG2855	membrane
IUA53_19120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUA53_19125	COG1349	DNA-binding transcription factor activity
IUA53_19130	COG0673	inositol 2-dehydrogenase activity
IUA53_19145	COG0697	spore germination
IUA53_19155	COG2169	Transcriptional regulator
IUA53_19165	COG1166	arginine decarboxylase activity
IUA53_19175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IUA53_19215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IUA53_19220	COG3507	Belongs to the glycosyl hydrolase 43 family
IUA53_19230	COG0109	protoheme IX farnesyltransferase activity
IUA53_19250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUA53_19265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IUA53_19295	COG1335	isochorismatase
IUA53_19300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUA53_19315	COG3384	dioxygenase
IUA53_19325	COG2175	clavaminate synthase activity
IUA53_19350	COG1324	tolerance protein
IUA53_19355	COG4232	protein-disulfide reductase activity
IUA53_19360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IUA53_19365	COG0511	ligase activity, forming carbon-carbon bonds
IUA53_19370	COG0439	Biotin carboxylase
IUA53_19410	COG3385	transposase activity
IUA53_19430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IUA53_19435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IUA53_19450	COG0151	Belongs to the GarS family
IUA53_19460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUA53_19470	COG3954	Phosphoribulokinase
IUA53_19495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IUA53_19500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUA53_19510	COG3031	protein transport across the cell outer membrane
IUA53_19520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUA53_19525	COG1459	type II secretion system
IUA53_19530	COG2165	general secretion pathway protein
IUA53_19540	COG2165	general secretion pathway protein
IUA53_19545	COG4795	General secretion pathway protein
IUA53_19550	COG3156	type II secretion system protein K
IUA53_19560	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IUA53_19575	COG1012	belongs to the aldehyde dehydrogenase family
IUA53_19585	COG1011	Hydrolase
IUA53_19590	COG0494	nUDIX hydrolase
IUA53_19595	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUA53_19605	COG2943	transferase activity, transferring hexosyl groups
IUA53_19610	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IUA53_19620	COG3089	Belongs to the UPF0270 family
IUA53_19625	COG0429	hydrolase of the alpha beta-hydrolase fold
IUA53_19635	COG0488	(ABC) transporter
IUA53_19660	COG0545	Peptidyl-prolyl cis-trans isomerase
IUA53_19670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IUA53_19675	COG2183	response to ionizing radiation
IUA53_19690	COG0596	Alpha beta hydrolase
IUA53_19695	COG1040	competence protein
IUA53_19710	COG1794	racemase activity, acting on amino acids and derivatives
IUA53_19715	COG2226	methyltransferase
IUA53_19725	COG0534	Mate efflux family protein
IUA53_19745	COG0109	protoheme IX farnesyltransferase activity
IUA53_19750	COG1612	heme a metabolic process
IUA53_19770	COG1845	cytochrome c oxidase, subunit III
IUA53_19780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUA53_19785	COG1565	acr, cog1565
IUA53_19785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUA53_19795	COG4774	siderophore transport
IUA53_19815	COG0129	dihydroxy-acid dehydratase activity
IUA53_19820	COG2860	membrane
IUA53_19825	COG0606	chelatase, subunit chli
IUA53_19830	COG0583	DNA-binding transcription factor activity
IUA53_19840	COG2814	Major facilitator Superfamily
IUA53_19845	COG0729	surface antigen
IUA53_19870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IUA53_19880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IUA53_19900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IUA53_19945	COG0425	Belongs to the sulfur carrier protein TusA family
IUA53_19960	COG1561	YicC-like family, N-terminal region
IUA53_19970	COG3012	SEC-C Motif Domain Protein
IUA53_19995	COG3550	peptidyl-serine autophosphorylation
IUA53_20005	COG1484	DNA-dependent DNA replication
IUA53_20055	COG2211	Major facilitator Superfamily
IUA53_20105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IUA53_20125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IUA53_20130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IUA53_20150	COG1475	DNA binding
IUA53_20155	COG1192	Involved in chromosome partitioning
IUA53_20180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUA53_20185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IUA53_20195	COG0706	membrane insertase activity
IUA53_20205	COG0594	ribonuclease P activity
IUA53_20210	COG0230	Belongs to the bacterial ribosomal protein bL34 family