locus-tag	class	description
D1814_00010	COG2814	Major facilitator Superfamily
D1814_00045	COG0708	Exodeoxyribonuclease III
D1814_00070	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1814_00080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1814_00090	COG2096	Adenosyltransferase
D1814_00095	COG1472	Belongs to the glycosyl hydrolase 3 family
D1814_00120	COG0072	phenylalanine-tRNA ligase activity
D1814_00120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1814_00140	COG0438	transferase activity, transferring glycosyl groups
D1814_00175	COG1215	transferase activity, transferring glycosyl groups
D1814_00180	COG0438	transferase activity, transferring glycosyl groups
D1814_00180	COG0297	glycogen (starch) synthase activity
D1814_00190	COG0297	glycogen (starch) synthase activity
D1814_00200	COG3300	MHYT domain
D1814_00200	COG5001	Diguanylate cyclase
D1814_00225	COG4464	protein tyrosine phosphatase activity
D1814_00230	COG0489	protein tyrosine kinase activity
D1814_00235	COG1596	polysaccharide export
D1814_00245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1814_00275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1814_00290	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_00320	COG0154	amidase activity
D1814_00330	COG0730	response to heat
D1814_00335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1814_00365	COG2205	protein histidine kinase activity
D1814_00365	COG0784	Response regulator, receiver
D1814_00370	COG3706	GGDEF domain
D1814_00370	COG0745	RESPONSE REGULATOR receiver
D1814_00385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1814_00390	COG2252	PERMEase
D1814_00395	COG4974	Belongs to the 'phage' integrase family
D1814_00400	COG3311	Transcriptional regulator
D1814_00420	COG1309	transcriptional regulator
D1814_00430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1814_00450	COG0402	S-adenosylhomocysteine deaminase activity
D1814_00460	COG3447	MASE1 domain protein
D1814_00460	COG5002	protein histidine kinase activity
D1814_00460	COG5001	Diguanylate cyclase
D1814_00470	COG1733	regulation of RNA biosynthetic process
D1814_00490	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1814_00510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_00525	COG5001	Diguanylate cyclase
D1814_00525	COG3300	MHYT domain
D1814_00545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1814_00560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1814_00560	COG1263	PTS System
D1814_00560	COG2190	(PTS) system
D1814_00565	COG1393	Belongs to the ArsC family
D1814_00590	COG1506	peptidase
D1814_00605	COG2988	succinylglutamate desuccinylase activity
D1814_00615	COG0058	SHG alpha-glucan phosphorylase activity
D1814_00620	COG0033	Phosphoglucomutase
D1814_00630	COG0714	Associated with various cellular activities
D1814_00645	COG2116	formate transmembrane transporter activity
D1814_00650	COG0515	serine threonine protein kinase
D1814_00655	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1814_00670	COG2363	Small membrane protein
D1814_00680	COG0583	DNA-binding transcription factor activity
D1814_00695	COG3094	Invasion gene expression up-regulator, SirB
D1814_00700	COG3437	response regulator, receiver
D1814_00700	COG0784	Response regulator, receiver
D1814_00705	COG2890	protein-(glutamine-N5) methyltransferase activity
D1814_00715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1814_00720	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D1814_00725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1814_00735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1814_00750	COG1064	alcohol dehydrogenase
D1814_00765	COG0012	GTP binding
D1814_00770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1814_00815	COG1115	amino acid carrier protein
D1814_00830	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_00835	COG1733	regulation of RNA biosynthetic process
D1814_00840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1814_00845	COG1607	acyl-coa hydrolase
D1814_00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1814_00900	COG4535	Mg2 and Co2 transporter CorC
D1814_00905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1814_00910	COG0857	belongs to the CobB CobQ family
D1814_00910	COG0280	phosphate acetyltransferase
D1814_00915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1814_00940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1814_00945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1814_00955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1814_00970	COG2200	EAL domain
D1814_00970	COG2199	diguanylate cyclase activity
D1814_00975	COG3909	cytochrome
D1814_00980	COG0484	heat shock protein binding
D1814_00990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1814_00995	COG2205	protein histidine kinase activity
D1814_00995	COG2198	Histidine kinase
D1814_00995	COG0784	Response regulator, receiver
D1814_01015	COG2610	gluconate transmembrane transporter activity
D1814_01020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1814_01030	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_01035	COG1454	alcohol dehydrogenase
D1814_01045	COG0783	Belongs to the Dps family
D1814_01050	COG0497	DNA recombination
D1814_01055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1814_01060	COG0500	methyltransferase
D1814_01065	COG2733	membrane
D1814_01075	COG0110	maltose O-acetyltransferase activity
D1814_01085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1814_01095	COG0009	L-threonylcarbamoyladenylate synthase
D1814_01100	COG0613	PHP domain protein
D1814_01105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1814_01115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1814_01120	COG0135	phosphoribosylanthranilate isomerase activity
D1814_01120	COG0134	indole-3-glycerol-phosphate synthase activity
D1814_01130	COG0159	tryptophan synthase activity
D1814_01135	COG2350	Protein conserved in bacteria
D1814_01150	COG0745	RESPONSE REGULATOR receiver
D1814_01160	COG0628	permease
D1814_01165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1814_01170	COG1090	epimerase
D1814_01175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D1814_01180	COG4181	ATPase activity
D1814_01200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1814_01245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1814_01275	COG0745	RESPONSE REGULATOR receiver
D1814_01285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1814_01290	COG5265	(ABC) transporter
D1814_01305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1814_01310	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D1814_01315	COG4139	cobalamin transport
D1814_01320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1814_01325	COG3340	Belongs to the peptidase S51 family
D1814_01335	COG2226	methyltransferase
D1814_01340	COG0156	8-amino-7-oxononanoate synthase activity
D1814_01375	COG0189	ligase activity
D1814_01390	COG0017	Asparaginyl-tRNA synthetase
D1814_01395	COG2207	Transcriptional regulator
D1814_01415	COG2995	paraquat-inducible protein a
D1814_01420	COG3008	intermembrane lipid transfer
D1814_01420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1814_01430	COG3706	GGDEF domain
D1814_01450	COG4774	siderophore transport
D1814_01455	COG1309	transcriptional regulator
D1814_01465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_01470	COG0517	IMP dehydrogenase activity
D1814_01475	COG1451	nucleotide metabolic process
D1814_01480	COG0604	alcohol dehydrogenase
D1814_01485	COG0583	DNA-binding transcription factor activity
D1814_01515	COG3038	cytochrome b561
D1814_01520	COG0300	oxidoreductase activity
D1814_01540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1814_01545	COG4667	esterase of the alpha-beta hydrolase superfamily
D1814_01575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1814_01595	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D1814_01600	COG2885	chlorophyll binding
D1814_01605	COG0823	Involved in the tonB-independent uptake of proteins
D1814_01620	COG0811	peptide transport
D1814_01625	COG0824	Thioesterase
D1814_01630	COG2255	four-way junction helicase activity
D1814_01645	COG0494	nUDIX hydrolase
D1814_01650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1814_01670	COG2204	response regulator
D1814_01680	COG2205	protein histidine kinase activity
D1814_01710	COG0023	Translation Initiation Factor
D1814_01715	COG0745	RESPONSE REGULATOR receiver
D1814_01720	COG1605	Chorismate mutase
D1814_01720	COG0077	Prephenate dehydratase
D1814_01725	COG0287	Prephenate dehydrogenase
D1814_01725	COG1605	Chorismate mutase
D1814_01730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1814_01745	COG2860	membrane
D1814_01750	COG0335	large ribosomal subunit rRNA binding
D1814_01755	COG0336	Belongs to the RNA methyltransferase TrmD family
D1814_01760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1814_01765	COG0228	four-way junction DNA binding
D1814_01780	COG1132	(ABC) transporter
D1814_01785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_01830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1814_01835	COG4137	Cytochrome C assembly protein
D1814_01840	COG4536	flavin adenine dinucleotide binding
D1814_01850	COG2062	phosphohistidine phosphatase, SixA
D1814_01855	COG1025	Belongs to the peptidase M16 family
D1814_01870	COG1024	Enoyl-CoA hydratase
D1814_01870	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1814_01880	COG0714	Associated with various cellular activities
D1814_01900	COG2304	oxidoreductase activity
D1814_01925	COG0745	RESPONSE REGULATOR receiver
D1814_01925	COG3706	GGDEF domain
D1814_01930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1814_01935	COG0175	sulfate reduction
D1814_01940	COG0529	Catalyzes the synthesis of activated sulfate
D1814_01955	COG3273	potassium ion transport
D1814_01955	COG0471	metal ion transport
D1814_01975	COG0367	asparagine synthase
D1814_01985	COG0602	queuosine metabolic process
D1814_02000	COG0556	nucleotide-excision repair
D1814_02005	COG0534	Mate efflux family protein
D1814_02025	COG2878	Part of a membrane complex involved in electron transport
D1814_02030	COG4656	Part of a membrane complex involved in electron transport
D1814_02035	COG4658	electron transport chain
D1814_02045	COG4660	Part of a membrane complex involved in electron transport
D1814_02050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1814_02070	COG1278	Cold shock
D1814_02075	COG0346	lactoylglutathione lyase activity
D1814_02080	COG0584	glycerophosphoryl diester phosphodiesterase
D1814_02085	COG2885	chlorophyll binding
D1814_02090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1814_02095	COG0450	alkyl hydroperoxide reductase
D1814_02120	COG4771	TonB-dependent receptor
D1814_02125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1814_02135	COG2766	serine protein kinase
D1814_02140	COG2718	Belongs to the UPF0229 family
D1814_02145	COG2719	SpoVR family
D1814_02160	COG2890	protein-(glutamine-N5) methyltransferase activity
D1814_02190	COG0612	Peptidase, M16
D1814_02200	COG0564	pseudouridine synthase activity
D1814_02210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1814_02265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1814_02275	COG2197	response regulator
D1814_02320	COG3706	GGDEF domain
D1814_02320	COG0745	RESPONSE REGULATOR receiver
D1814_02325	COG0656	L-ascorbic acid biosynthetic process
D1814_02335	COG2814	Major facilitator Superfamily
D1814_02340	COG0583	DNA-binding transcription factor activity
D1814_02355	COG0456	acetyltransferase
D1814_02395	COG1444	tRNA N-acetyltransferase activity
D1814_02410	COG0848	biopolymer transport protein
D1814_02415	COG0811	peptide transport
D1814_02420	COG0811	peptide transport
D1814_02435	COG0457	Tetratricopeptide repeat
D1814_02465	COG0457	Tetratricopeptide repeat
D1814_02490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1814_02495	COG1522	sequence-specific DNA binding
D1814_02500	COG0625	glutathione transferase activity
D1814_02530	COG1842	Phage shock protein A
D1814_02535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D1814_02540	COG0747	negative chemotaxis
D1814_02545	COG4168	peptide transport system, permease
D1814_02550	COG4171	peptide transport system, permease
D1814_02555	COG4172	Belongs to the ABC transporter superfamily
D1814_02560	COG4172	Belongs to the ABC transporter superfamily
D1814_02565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1814_02570	COG0511	ligase activity, forming carbon-carbon bonds
D1814_02570	COG5016	pyruvate
D1814_02600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1814_02605	COG2137	regulation of response to DNA damage stimulus
D1814_02615	COG3590	peptidase
D1814_02620	COG1309	transcriptional regulator
D1814_02630	COG0659	secondary active sulfate transmembrane transporter activity
D1814_02640	COG0583	DNA-binding transcription factor activity
D1814_02645	COG0583	DNA-binding transcription factor activity
D1814_02650	COG3123	guanosine phosphorylase activity
D1814_02660	COG0646	methionine synthase
D1814_02660	COG1410	methionine synthase
D1814_02665	COG1410	methionine synthase
D1814_02665	COG0646	methionine synthase
D1814_02680	COG0835	chemotaxis
D1814_02690	COG1192	Involved in chromosome partitioning
D1814_02695	COG2201	protein-glutamate methylesterase activity
D1814_02700	COG0643	Histidine kinase
D1814_02700	COG2198	Histidine kinase
D1814_02705	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D1814_02720	COG0455	bacterial-type flagellum organization
D1814_02730	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D1814_02745	COG1987	bacterial-type flagellum assembly
D1814_02795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D1814_02800	COG1766	The M ring may be actively involved in energy transduction
D1814_02805	COG1677	Flagellar hook-basal body complex protein FliE
D1814_02810	COG2204	response regulator
D1814_02815	COG3852	Histidine kinase
D1814_02820	COG2204	response regulator
D1814_02830	COG1086	Polysaccharide biosynthesis protein
D1814_02835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1814_02840	COG2089	acid synthase
D1814_02845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1814_02850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1814_02870	COG1083	cytidylyl-transferase
D1814_02900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1814_02905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1814_02920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1814_02925	COG1256	bacterial-type flagellum assembly
D1814_02930	COG3951	Flagellar rod assembly protein muramidase FlgJ
D1814_02930	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1814_02945	COG4786	Flagellar basal body rod
D1814_02950	COG4787	bacterial-type flagellum-dependent cell motility
D1814_02955	COG1749	Flagellar hook protein flgE
D1814_02960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1814_02965	COG1558	bacterial-type flagellum-dependent cell motility
D1814_02970	COG1815	bacterial-type flagellum-dependent cell motility
D1814_02975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D1814_02980	COG0835	chemotaxis
D1814_02980	COG0784	Response regulator, receiver
D1814_03020	COG4566	intracellular signal transduction
D1814_03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_03050	COG2840	Smr protein MutS2
D1814_03055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1814_03055	COG0047	phosphoribosylformylglycinamidine synthase activity
D1814_03065	COG0590	tRNA wobble adenosine to inosine editing
D1814_03080	COG3706	GGDEF domain
D1814_03085	COG0037	tRNA processing
D1814_03090	COG0825	malonyl-CoA metabolic process
D1814_03095	COG0587	DNA-directed DNA polymerase activity
D1814_03115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1814_03130	COG0750	zinc metalloprotease
D1814_03140	COG0575	Belongs to the CDS family
D1814_03145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1814_03155	COG0528	UMP kinase activity
D1814_03165	COG0052	Belongs to the universal ribosomal protein uS2 family
D1814_03170	COG0024	Methionine aminopeptidase
D1814_03175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1814_03190	COG0564	pseudouridine synthase activity
D1814_03235	COG3706	GGDEF domain
D1814_03240	COG1611	Belongs to the LOG family
D1814_03255	COG0473	3-isopropylmalate dehydrogenase activity
D1814_03260	COG1555	photosystem II stabilization
D1814_03260	COG1596	polysaccharide export
D1814_03265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1814_03280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1814_03310	COG3104	oligopeptide transport
D1814_03320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1814_03325	COG2853	Lipoprotein
D1814_03345	COG1138	Cytochrome C-type biogenesis protein
D1814_03355	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1814_03360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1814_03365	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1814_03370	COG4133	protoheme IX ABC transporter activity
D1814_03385	COG1668	transmembrane transport
D1814_03390	COG4555	ABC transporter
D1814_03430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1814_03435	COG0473	3-isopropylmalate dehydrogenase activity
D1814_03445	COG0066	3-isopropylmalate dehydratase activity
D1814_03460	COG3409	Peptidoglycan-binding domain 1 protein
D1814_03460	COG3267	Type II secretory pathway component ExeA
D1814_03480	COG0513	Belongs to the DEAD box helicase family
D1814_03485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1814_03490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1814_03520	COG1346	cytolysis
D1814_03560	COG2814	Major facilitator Superfamily
D1814_03570	COG0668	transmembrane transport
D1814_03590	COG0488	(ABC) transporter
D1814_03610	COG2986	histidine ammonia-lyase
D1814_03645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1814_03655	COG0419	ATPase involved in DNA repair
D1814_03680	COG1739	Uncharacterized protein family UPF0029
D1814_03695	COG1764	response to oxidative stress
D1814_03700	COG1846	Transcriptional regulator
D1814_03705	COG1272	protein, Hemolysin III
D1814_03715	COG0583	DNA-binding transcription factor activity
D1814_03725	COG0306	phosphate transporter
D1814_03735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1814_03745	COG0573	inorganic phosphate transmembrane transporter activity
D1814_03755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1814_03760	COG0248	Ppx GppA phosphatase
D1814_03765	COG4946	Tricorn protease homolog
D1814_03765	COG1506	peptidase
D1814_03765	COG0823	Involved in the tonB-independent uptake of proteins
D1814_03770	COG1538	Outer membrane efflux protein
D1814_03780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_03790	COG3588	fructose-bisphosphate aldolase
D1814_03795	COG0126	phosphoglycerate kinase activity
D1814_03805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1814_03830	COG2205	protein histidine kinase activity
D1814_03830	COG0784	Response regulator, receiver
D1814_03835	COG0697	spore germination
D1814_03840	COG4771	TonB-dependent receptor
D1814_03855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1814_03890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1814_03900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1814_03905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1814_03915	COG5007	Belongs to the BolA IbaG family
D1814_03925	COG2854	intermembrane phospholipid transfer
D1814_03930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1814_03935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1814_03940	COG1127	ABC transporter
D1814_03955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1814_03965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1814_03970	COG1137	ATPase activity
D1814_03975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D1814_03985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1814_03995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1814_04000	COG2239	Acts as a magnesium transporter
D1814_04005	COG0745	RESPONSE REGULATOR receiver
D1814_04020	COG2969	positive regulation of protein catabolic process
D1814_04025	COG0625	glutathione transferase activity
D1814_04030	COG2857	Cytochrome c1
D1814_04035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1814_04040	COG0723	plastoquinol--plastocyanin reductase activity
D1814_04045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1814_04065	COG4771	TonB-dependent receptor
D1814_04080	COG3956	TIGRFAM MazG family protein
D1814_04085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1814_04100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1814_04120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1814_04130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1814_04135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1814_04140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1814_04145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1814_04155	COG2967	ApaG domain
D1814_04160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1814_04170	COG0527	aspartate kinase activity
D1814_04195	COG2819	hydrolase of the alpha beta superfamily
D1814_04200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1814_04205	COG1049	propionate catabolic process, 2-methylcitrate cycle
D1814_04210	COG2133	pyrroloquinoline quinone binding
D1814_04220	COG0318	PFAM AMP-dependent synthetase and ligase
D1814_04225	COG0784	Response regulator, receiver
D1814_04225	COG5002	protein histidine kinase activity
D1814_04225	COG2205	protein histidine kinase activity
D1814_04230	COG3437	response regulator, receiver
D1814_04240	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D1814_04245	COG0848	biopolymer transport protein
D1814_04250	COG0811	peptide transport
D1814_04255	COG0811	peptide transport
D1814_04285	COG5002	protein histidine kinase activity
D1814_04290	COG0745	RESPONSE REGULATOR receiver
D1814_04295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1814_04295	COG4191	Histidine kinase
D1814_04300	COG2974	May be involved in recombination
D1814_04305	COG1396	sequence-specific DNA binding
D1814_04310	COG3135	benzoate transporter
D1814_04325	COG0537	adenosine 5'-monophosphoramidase activity
D1814_04340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1814_04345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1814_04370	COG0358	DNA primase activity
D1814_04395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_04415	COG4948	Mandelate Racemase Muconate Lactonizing
D1814_04425	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_04430	COG1960	acyl-CoA dehydrogenase activity
D1814_04445	COG0348	domain, Protein
D1814_04450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1814_04455	COG4206	TonB-dependent receptor
D1814_04460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1814_04475	COG1116	anion transmembrane transporter activity
D1814_04485	COG1116	anion transmembrane transporter activity
D1814_04485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1814_04495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1814_04500	COG1648	precorrin-2 dehydrogenase activity
D1814_04500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1814_04505	COG0243	molybdopterin cofactor binding
D1814_04510	COG2146	nitrite reductase [NAD(P)H] activity
D1814_04515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1814_04525	COG0659	secondary active sulfate transmembrane transporter activity
D1814_04535	COG3707	response regulator
D1814_04545	COG0671	phosphoesterase, PA-phosphatase related
D1814_04550	COG0271	Belongs to the BolA IbaG family
D1814_04565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1814_04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1814_04585	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D1814_04595	COG1509	lysine 2,3-aminomutase activity
D1814_04615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1814_04625	COG0187	DNA topoisomerase II activity
D1814_04630	COG3150	esterase
D1814_04635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1814_04645	COG0494	nUDIX hydrolase
D1814_04650	COG1538	Outer membrane efflux protein
D1814_04665	COG0513	Belongs to the DEAD box helicase family
D1814_04670	COG1648	precorrin-2 dehydrogenase activity
D1814_04670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1814_04680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1814_04695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1814_04715	COG2211	Major facilitator Superfamily
D1814_04720	COG5002	protein histidine kinase activity
D1814_04720	COG0784	Response regulator, receiver
D1814_04725	COG3706	GGDEF domain
D1814_04730	COG2201	protein-glutamate methylesterase activity
D1814_04735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1814_04740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1814_04745	COG0730	response to heat
D1814_04750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D1814_04755	COG0494	nUDIX hydrolase
D1814_04780	COG5002	protein histidine kinase activity
D1814_04785	COG0745	RESPONSE REGULATOR receiver
D1814_04790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_04815	COG0840	transmembrane signaling receptor activity
D1814_04825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1814_04835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1814_04840	COG0585	pseudouridine synthase activity
D1814_04850	COG1238	metal cluster binding
D1814_04855	COG1388	LysM domain
D1814_04855	COG4942	peptidase
D1814_04895	COG0142	geranyltranstransferase activity
D1814_04905	COG0006	proline dipeptidase activity
D1814_04915	COG1024	Enoyl-CoA hydratase
D1814_04915	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1814_04920	COG0183	Belongs to the thiolase family
D1814_05015	COG3547	Transposase (IS116 IS110 IS902 family)
D1814_05040	COG0454	-acetyltransferase
D1814_05045	COG2824	Alkylphosphonate utilization operon protein PhnA
D1814_05055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1814_05085	COG0346	lactoylglutathione lyase activity
D1814_05095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1814_05105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1814_05125	COG1757	Na H antiporter
D1814_05165	COG1012	belongs to the aldehyde dehydrogenase family
D1814_05175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D1814_05190	COG3118	belongs to the thioredoxin family
D1814_05200	COG4946	Tricorn protease homolog
D1814_05200	COG1506	peptidase
D1814_05200	COG0823	Involved in the tonB-independent uptake of proteins
D1814_05205	COG2133	pyrroloquinoline quinone binding
D1814_05210	COG0783	Belongs to the Dps family
D1814_05225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1814_05235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1814_05240	COG0784	Response regulator, receiver
D1814_05240	COG5002	protein histidine kinase activity
D1814_05245	COG1473	amidohydrolase
D1814_05250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1814_05260	COG3118	belongs to the thioredoxin family
D1814_05265	COG0513	Belongs to the DEAD box helicase family
D1814_05270	COG0248	Ppx GppA phosphatase
D1814_05280	COG5001	Diguanylate cyclase
D1814_05280	COG4251	negative regulation of phosphorylation
D1814_05280	COG2203	Gaf domain
D1814_05280	COG3706	GGDEF domain
D1814_05285	COG0084	hydrolase, TatD family'
D1814_05295	COG0805	protein transport
D1814_05300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1814_05320	COG0028	Belongs to the TPP enzyme family
D1814_05335	COG0457	Tetratricopeptide repeat
D1814_05355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1814_05360	COG1162	GTPase activity
D1814_05375	COG0584	glycerophosphoryl diester phosphodiesterase
D1814_05385	COG2861	carbohydrate metabolic process
D1814_05395	COG4942	peptidase
D1814_05400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1814_05405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1814_05415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1814_05425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1814_05430	COG2267	carboxylic ester hydrolase activity
D1814_05435	COG2205	protein histidine kinase activity
D1814_05440	COG0745	RESPONSE REGULATOR receiver
D1814_05455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1814_05465	COG1803	Methylglyoxal synthase
D1814_05485	COG0137	argininosuccinate synthase activity
D1814_05495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1814_05495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1814_05500	COG3300	MHYT domain
D1814_05500	COG5001	Diguanylate cyclase
D1814_05535	COG0753	catalase activity
D1814_05555	COG0625	glutathione transferase activity
D1814_05565	COG0281	malic enzyme
D1814_05570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1814_05605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1814_05615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1814_05635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1814_05640	COG0180	Tryptophanyl-tRNA synthetase
D1814_05655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1814_05665	COG1012	belongs to the aldehyde dehydrogenase family
D1814_05675	COG3300	MHYT domain
D1814_05675	COG5001	Diguanylate cyclase
D1814_05690	COG5002	protein histidine kinase activity
D1814_05690	COG0784	Response regulator, receiver
D1814_05690	COG2205	protein histidine kinase activity
D1814_05705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_05715	COG0540	Belongs to the ATCase OTCase family
D1814_05730	COG2837	iron assimilation
D1814_05735	COG0405	Gamma-glutamyltransferase
D1814_05740	COG0004	ammonium transporteR
D1814_05755	COG2207	Transcriptional regulator
D1814_05760	COG2354	Protein conserved in bacteria
D1814_05770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1814_05775	COG2951	lytic endotransglycosylase activity
D1814_05785	COG1643	Atp-dependent helicase
D1814_05795	COG0788	formyltetrahydrofolate deformylase activity
D1814_05840	COG1519	Transferase
D1814_05850	COG0438	transferase activity, transferring glycosyl groups
D1814_05855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1814_05870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1814_05880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1814_05890	COG0089	rRNA binding
D1814_05910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1814_05975	COG1454	alcohol dehydrogenase
D1814_05995	COG1082	Xylose isomerase domain protein TIM barrel
D1814_06000	COG2211	Major facilitator Superfamily
D1814_06010	COG0673	inositol 2-dehydrogenase activity
D1814_06015	COG1609	Transcriptional regulator
D1814_06030	COG5002	protein histidine kinase activity
D1814_06035	COG0546	phosphoglycolate phosphatase activity
D1814_06065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D1814_06085	COG0835	chemotaxis
D1814_06090	COG0643	Histidine kinase
D1814_06090	COG2198	Histidine kinase
D1814_06095	COG0745	RESPONSE REGULATOR receiver
D1814_06110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D1814_06125	COG0835	chemotaxis
D1814_06130	COG0643	Histidine kinase
D1814_06130	COG2198	Histidine kinase
D1814_06135	COG0745	RESPONSE REGULATOR receiver
D1814_06165	COG2814	Major facilitator Superfamily
D1814_06215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1814_06225	COG0297	glycogen (starch) synthase activity
D1814_06230	COG4191	Histidine kinase
D1814_06230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1814_06235	COG0745	RESPONSE REGULATOR receiver
D1814_06250	COG0312	modulator of DNA gyrase
D1814_06255	COG3028	Belongs to the UPF0307 family
D1814_06260	COG0312	modulator of DNA gyrase
D1814_06265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1814_06275	COG1530	ribonuclease E activity
D1814_06285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1814_06290	COG1792	Involved in formation and maintenance of cell shape
D1814_06295	COG1077	Cell shape determining protein MreB Mrl
D1814_06340	COG1459	type II secretion system
D1814_06345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1814_06400	COG1349	DNA-binding transcription factor activity
D1814_06425	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1814_06445	COG0629	single-stranded DNA binding
D1814_06455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1814_06460	COG1085	galactose-1-phosphate uridylyltransferase
D1814_06485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1814_06490	COG2814	Major facilitator Superfamily
D1814_06495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1814_06500	COG1077	Cell shape determining protein MreB Mrl
D1814_06525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1814_06535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1814_06540	COG0163	prenyltransferase activity
D1814_06570	COG0019	diaminopimelate decarboxylase activity
D1814_06575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1814_06590	COG1011	Hydrolase
D1814_06600	COG0210	DNA helicase
D1814_06605	COG3706	GGDEF domain
D1814_06605	COG0745	RESPONSE REGULATOR receiver
D1814_06610	COG2962	Rard protein
D1814_06615	COG2239	Acts as a magnesium transporter
D1814_06620	COG2050	protein possibly involved in aromatic compounds catabolism
D1814_06625	COG0514	ATP-dependent DNA helicase (RecQ)
D1814_06640	COG5002	protein histidine kinase activity
D1814_06640	COG5001	Diguanylate cyclase
D1814_06650	COG3064	Membrane
D1814_06660	COG0840	transmembrane signaling receptor activity
D1814_06675	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1814_06680	COG0427	acetyl-CoA hydrolase
D1814_06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_06710	COG2076	Multidrug Resistance protein
D1814_06720	COG0583	DNA-binding transcription factor activity
D1814_06725	COG3706	GGDEF domain
D1814_06740	COG2081	HI0933 family
D1814_06745	COG0668	transmembrane transport
D1814_06750	COG3842	ATPase activity
D1814_06755	COG1178	ABC-type Fe3 transport system permease component
D1814_06770	COG0678	peroxiredoxin activity
D1814_06780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1814_06785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1814_06795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1814_06920	COG0194	GDP metabolic process
D1814_06930	COG3706	GGDEF domain
D1814_06930	COG0745	RESPONSE REGULATOR receiver
D1814_06935	COG0181	hydroxymethylbilane synthase activity
D1814_06945	COG2959	enzyme of heme biosynthesis
D1814_06950	COG3071	HemY protein
D1814_06960	COG0352	thiamine-phosphate diphosphorylase activity
D1814_06980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1814_06995	COG3106	COG3106 Predicted ATPase
D1814_07005	COG0583	DNA-binding transcription factor activity
D1814_07020	COG4771	TonB-dependent receptor
D1814_07050	COG1674	ftsk spoiiie
D1814_07090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1814_07105	COG4771	TonB-dependent receptor
D1814_07115	COG1472	Belongs to the glycosyl hydrolase 3 family
D1814_07120	COG2207	Transcriptional regulator
D1814_07130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1814_07160	COG1621	beta-fructofuranosidase activity
D1814_07170	COG2211	Major facilitator Superfamily
D1814_07190	COG0210	DNA helicase
D1814_07210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1814_07215	COG3161	chorismate lyase activity
D1814_07230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1814_07260	COG0859	PFAM glycosyl transferase family 9
D1814_07295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1814_07320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1814_07340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1814_07340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1814_07345	COG2234	aminopeptidase activity
D1814_07420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1814_07435	COG3047	cAMP biosynthetic process
D1814_07440	COG0408	coproporphyrinogen oxidase activity
D1814_07445	COG0009	L-threonylcarbamoyladenylate synthase
D1814_07460	COG0758	DNA mediated transformation
D1814_07465	COG1652	LysM domain
D1814_07480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1814_07480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1814_07485	COG0569	domain protein
D1814_07490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1814_07495	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D1814_07500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1814_07500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1814_07520	COG3078	GTPase activator activity
D1814_07530	COG2818	Glycosylase
D1814_07550	COG0187	DNA topoisomerase II activity
D1814_07555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1814_07565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1814_07570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1814_07575	COG0594	ribonuclease P activity
D1814_07580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1814_07585	COG0706	membrane insertase activity
D1814_07595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1814_07600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1814_07625	COG1192	Involved in chromosome partitioning
D1814_07630	COG1475	DNA binding
D1814_07650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1814_07655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1814_07675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1814_07705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1814_07705	COG2199	diguanylate cyclase activity
D1814_07720	COG1609	Transcriptional regulator
D1814_07725	COG2211	Major facilitator Superfamily
D1814_07730	COG2723	6-phospho-beta-galactosidase activity
D1814_07755	COG1561	YicC-like family, N-terminal region
D1814_07770	COG0425	Belongs to the sulfur carrier protein TusA family
D1814_07795	COG1228	amidohydrolase
D1814_07820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1814_07840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1814_07850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1814_07875	COG2911	Protein conserved in bacteria
D1814_07880	COG0729	surface antigen
D1814_07890	COG2814	Major facilitator Superfamily
D1814_07900	COG0583	DNA-binding transcription factor activity
D1814_07905	COG0606	chelatase, subunit chli
D1814_07915	COG0129	dihydroxy-acid dehydratase activity
D1814_07940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1814_07945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1814_07975	COG1612	heme a metabolic process
D1814_07980	COG0109	protoheme IX farnesyltransferase activity
D1814_07985	COG1999	signal sequence binding
D1814_07995	COG0726	polysaccharide deacetylase
D1814_07995	COG1649	PFAM Uncharacterised BCR, COG1649
D1814_08000	COG0534	Mate efflux family protein
D1814_08005	COG2226	methyltransferase
D1814_08015	COG1794	racemase activity, acting on amino acids and derivatives
D1814_08035	COG1040	competence protein
D1814_08040	COG0596	Alpha beta hydrolase
D1814_08060	COG2183	response to ionizing radiation
D1814_08065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1814_08075	COG0545	Peptidyl-prolyl cis-trans isomerase
D1814_08085	COG2900	Belongs to the SlyX family
D1814_08100	COG0488	(ABC) transporter
D1814_08110	COG0429	hydrolase of the alpha beta-hydrolase fold
D1814_08115	COG3089	Belongs to the UPF0270 family
D1814_08130	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D1814_08145	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1814_08150	COG0494	nUDIX hydrolase
D1814_08155	COG1011	Hydrolase
D1814_08165	COG1012	belongs to the aldehyde dehydrogenase family
D1814_08170	COG1234	tRNA 3'-trailer cleavage
D1814_08185	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D1814_08195	COG3156	type II secretion system protein K
D1814_08200	COG4795	General secretion pathway protein
D1814_08205	COG2165	general secretion pathway protein
D1814_08210	COG2165	general secretion pathway protein
D1814_08215	COG2165	general secretion pathway protein
D1814_08220	COG1459	type II secretion system
D1814_08225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1814_08235	COG3031	protein transport across the cell outer membrane
D1814_08245	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D1814_08255	COG1501	Belongs to the glycosyl hydrolase 31 family
D1814_08270	COG0745	RESPONSE REGULATOR receiver
D1814_08280	COG3954	Phosphoribulokinase
D1814_08285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1814_08305	COG0151	Belongs to the GarS family
D1814_08320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1814_08325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1814_08340	COG0154	amidase activity
D1814_08365	COG2176	DNA-directed DNA polymerase activity
D1814_08385	COG0439	Biotin carboxylase
D1814_08390	COG0511	ligase activity, forming carbon-carbon bonds
D1814_08395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1814_08400	COG4232	protein-disulfide reductase activity
D1814_08405	COG1324	tolerance protein
D1814_08430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1814_08450	COG0109	protoheme IX farnesyltransferase activity
D1814_08455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1814_08470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1814_08475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1814_08480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1814_08490	COG1166	arginine decarboxylase activity
D1814_08495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1814_08500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D1814_08505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1814_08525	COG0673	inositol 2-dehydrogenase activity
D1814_08535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1814_08580	COG0789	Transcriptional regulator
D1814_08625	COG0701	Predicted permease
D1814_08645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_08715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1814_08725	COG2205	protein histidine kinase activity
D1814_08725	COG0784	Response regulator, receiver
D1814_08730	COG4251	negative regulation of phosphorylation
D1814_08730	COG3706	GGDEF domain
D1814_08730	COG2203	Gaf domain
D1814_08730	COG5001	Diguanylate cyclase
D1814_08735	COG2130	NADP-dependent
D1814_08740	COG2067	long-chain fatty acid transport protein
D1814_08745	COG0583	DNA-binding transcription factor activity
D1814_08755	COG4206	TonB-dependent receptor
D1814_08760	COG1252	NADH dehydrogenase
D1814_08780	COG0596	Alpha beta hydrolase
D1814_08780	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1814_08805	COG1404	Belongs to the peptidase S8 family
D1814_08810	COG1595	DNA-templated transcription, initiation
D1814_08825	COG3237	CsbD-like
D1814_08830	COG2375	cellular response to nickel ion
D1814_08860	COG1469	GTP cyclohydrolase I activity
D1814_08875	COG4771	TonB-dependent receptor
D1814_08885	COG4319	ketosteroid isomerase
D1814_08915	COG1294	oxidase, subunit
D1814_08920	COG4890	Cyd operon protein YbgT
D1814_08925	COG4988	ABC transporter
D1814_08930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1814_08935	COG2814	Major facilitator Superfamily
D1814_08935	COG0477	Major facilitator Superfamily
D1814_08940	COG1609	Transcriptional regulator
D1814_08945	COG2723	6-phospho-beta-galactosidase activity
D1814_08990	COG4771	TonB-dependent receptor
D1814_08995	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1814_09015	COG0656	L-ascorbic acid biosynthetic process
D1814_09020	COG2175	clavaminate synthase activity
D1814_09025	COG2855	membrane
D1814_09040	COG0840	transmembrane signaling receptor activity
D1814_09045	COG5002	protein histidine kinase activity
D1814_09050	COG0840	transmembrane signaling receptor activity
D1814_09070	COG2198	Histidine kinase
D1814_09070	COG0784	Response regulator, receiver
D1814_09070	COG2205	protein histidine kinase activity
D1814_09115	COG2258	MOSC domain
D1814_09140	COG0305	Participates in initiation and elongation during chromosome replication
D1814_09150	COG0432	Pfam Uncharacterised protein family UPF0047
D1814_09160	COG0735	belongs to the Fur family
D1814_09165	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D1814_09175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1814_09185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1814_09190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1814_09190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1814_09195	COG0802	atpase or kinase
D1814_09210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1814_09215	COG1923	regulation of RNA biosynthetic process
D1814_09220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1814_09225	COG0330	HflC and HflK could
D1814_09230	COG0330	HflC and HflK could
D1814_09235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1814_09240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1814_09250	COG0028	Belongs to the TPP enzyme family
D1814_09255	COG1012	belongs to the aldehyde dehydrogenase family
D1814_09265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1814_09270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D1814_09285	COG0625	glutathione transferase activity
D1814_09290	COG1410	methionine synthase
D1814_09290	COG0646	methionine synthase
D1814_09295	COG1940	carbohydrate kinase activity
D1814_09300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1814_09305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1814_09310	COG1793	dna ligase
D1814_09320	COG2311	Membrane
D1814_09325	COG1201	RNA secondary structure unwinding
D1814_09335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1814_09340	COG2957	Belongs to the agmatine deiminase family
D1814_09360	COG0302	gtp cyclohydrolase
D1814_09380	COG0668	transmembrane transport
D1814_09385	COG0346	lactoylglutathione lyase activity
D1814_09390	COG4989	oxidoreductase activity
D1814_09395	COG3040	lipid binding
D1814_09400	COG0418	dihydroorotase activity
D1814_09405	COG0513	Belongs to the DEAD box helicase family
D1814_09415	COG3590	peptidase
D1814_09420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1814_09430	COG1132	(ABC) transporter
D1814_09440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1814_09445	COG0250	Participates in transcription elongation, termination and antitermination
D1814_09450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1814_09455	COG0081	regulation of translation
D1814_09460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1814_09465	COG0222	ribosome binding
D1814_09470	COG0085	RNA polymerase activity
D1814_09475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1814_09480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1814_09485	COG0049	tRNA binding
D1814_09490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1814_09520	COG1966	Carbon starvation protein
D1814_09530	COG1253	flavin adenine dinucleotide binding
D1814_09555	COG4774	siderophore transport
D1814_09560	COG2205	protein histidine kinase activity
D1814_09565	COG0745	RESPONSE REGULATOR receiver
D1814_09575	COG1131	(ABC) transporter
D1814_09580	COG0842	Transport permease protein
D1814_09595	COG0076	glutamate decarboxylase activity
D1814_09610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1814_09620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1814_09625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1814_09645	COG2095	MarC family integral membrane protein
D1814_09655	COG0742	ribosomal rna small subunit methyltransferase
D1814_09660	COG0552	protein localization to endoplasmic reticulum
D1814_09665	COG2884	Cell division ATP-binding protein ftsE
D1814_09670	COG2177	Part of the ABC transporter FtsEX involved in
D1814_09675	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D1814_09680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D1814_09690	COG0456	acetyltransferase
D1814_09720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1814_09730	COG0281	malic enzyme
D1814_09745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1814_09750	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1814_09760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1814_09785	COG2197	response regulator
D1814_09795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_09805	COG1506	peptidase
D1814_09805	COG4946	Tricorn protease homolog
D1814_09805	COG0823	Involved in the tonB-independent uptake of proteins
D1814_09815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1814_09825	COG4191	Histidine kinase
D1814_09835	COG2201	protein-glutamate methylesterase activity
D1814_09840	COG0339	signal peptide processing
D1814_09850	COG2226	methyltransferase
D1814_09860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1814_09865	COG1278	Cold shock
D1814_09875	COG1522	sequence-specific DNA binding
D1814_09880	COG1294	oxidase, subunit
D1814_09885	COG1271	oxidase subunit
D1814_09920	COG2234	aminopeptidase activity
D1814_09935	COG0543	2 iron, 2 sulfur cluster binding
D1814_09950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D1814_09970	COG4771	TonB-dependent receptor
D1814_09980	COG0557	exoribonuclease II activity
D1814_10035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1814_10055	COG0201	protein transport
D1814_10080	COG0202	RNA polymerase activity
D1814_10135	COG1215	transferase activity, transferring glycosyl groups
D1814_10170	COG1091	dTDP-4-dehydrorhamnose reductase activity
D1814_10180	COG1216	Glycosyl transferase, family 2
D1814_10180	COG0438	transferase activity, transferring glycosyl groups
D1814_10215	COG0583	DNA-binding transcription factor activity
D1814_10265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1814_10275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1814_10340	COG2815	serine threonine protein kinase
D1814_10340	COG0515	serine threonine protein kinase
D1814_10365	COG0667	Aldo Keto reductase
D1814_10370	COG1283	sodium-dependent phosphate transmembrane transporter activity
D1814_10380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1814_10395	COG4067	protein conserved in archaea
D1814_10395	COG0189	ligase activity
D1814_10405	COG0189	ligase activity
D1814_10415	COG2205	protein histidine kinase activity
D1814_10425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1814_10440	COG3706	GGDEF domain
D1814_10440	COG0745	RESPONSE REGULATOR receiver
D1814_10450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1814_10465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1814_10470	COG0572	uridine kinase
D1814_10500	COG1438	arginine binding
D1814_10505	COG0039	L-malate dehydrogenase activity
D1814_10520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1814_10525	COG0545	Peptidyl-prolyl cis-trans isomerase
D1814_10530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1814_10540	COG1805	sodium ion transport
D1814_10545	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1814_10550	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1814_10555	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1814_10560	COG2871	sodium ion transport
D1814_10565	COG1477	protein flavinylation
D1814_10580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1814_10590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1814_10595	COG4628	conserved protein (DUF2132)
D1814_10600	COG1309	transcriptional regulator
D1814_10605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1814_10610	COG1335	isochorismatase
D1814_10615	COG0251	oxidation-reduction process
D1814_10620	COG0596	Alpha beta hydrolase
D1814_10625	COG0778	Nitroreductase
D1814_10630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1814_10640	COG4771	TonB-dependent receptor
D1814_10645	COG1953	Uracil, thiamine, allantoin
D1814_10665	COG4682	membrane
D1814_10675	COG0121	glutamine amidotransferase
D1814_10680	COG0583	DNA-binding transcription factor activity
D1814_10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1814_10700	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D1814_10710	COG5001	Diguanylate cyclase
D1814_10710	COG5002	protein histidine kinase activity
D1814_10725	COG0702	epimerase
D1814_10730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1814_10760	COG0457	Tetratricopeptide repeat
D1814_10775	COG0848	biopolymer transport protein
D1814_10785	COG0716	FMN binding
D1814_10800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1814_10815	COG0733	neurotransmitter:sodium symporter activity
D1814_10820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1814_10835	COG0668	transmembrane transport
D1814_10840	COG0204	Acyl-transferase
D1814_10845	COG0204	Acyl-transferase
D1814_10890	COG0438	transferase activity, transferring glycosyl groups
D1814_10900	COG4529	Protein conserved in bacteria
D1814_10920	COG1842	Phage shock protein A
D1814_10925	COG1983	PspC domain protein
D1814_10945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1814_10965	COG5001	Diguanylate cyclase
D1814_10965	COG3300	MHYT domain
D1814_10970	COG1573	uracil-dna glycosylase
D1814_10980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1814_11040	COG0318	PFAM AMP-dependent synthetase and ligase
D1814_11050	COG0417	DNA replication proofreading
D1814_11060	COG4191	Histidine kinase
D1814_11080	COG0730	response to heat
D1814_11135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1814_11140	COG0800	Aldolase
D1814_11155	COG5001	Diguanylate cyclase
D1814_11155	COG3300	MHYT domain
D1814_11160	COG0513	Belongs to the DEAD box helicase family
D1814_11180	COG4585	Histidine kinase
D1814_11185	COG2197	response regulator
D1814_11215	COG1462	curli production assembly transport component CsgG
D1814_11220	COG2197	response regulator
D1814_11225	COG0277	FAD linked oxidase domain protein
D1814_11230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1814_11260	COG2197	response regulator
D1814_11270	COG3901	Regulator of nitric oxide reductase transcription
D1814_11270	COG0348	domain, Protein
D1814_11280	COG2205	protein histidine kinase activity
D1814_11335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1814_11380	COG1609	Transcriptional regulator
D1814_11385	COG4948	Mandelate Racemase Muconate Lactonizing
D1814_11390	COG0673	inositol 2-dehydrogenase activity
D1814_11405	COG2267	carboxylic ester hydrolase activity
D1814_11425	COG0395	ABC-type sugar transport system, permease component
D1814_11435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1814_11455	COG3093	addiction module antidote protein HigA
D1814_11500	COG0679	Auxin Efflux Carrier
D1814_11505	COG0745	RESPONSE REGULATOR receiver
D1814_11505	COG3706	GGDEF domain
D1814_11510	COG1609	Transcriptional regulator
D1814_11530	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_11540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1814_11555	COG0006	proline dipeptidase activity
D1814_11585	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_11595	COG3246	L-lysine catabolic process to acetate
D1814_11600	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1814_11625	COG0697	spore germination
D1814_11630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1814_11640	COG4206	TonB-dependent receptor
D1814_11650	COG4558	Periplasmic binding protein
D1814_11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1814_11660	COG1120	ATPase activity
D1814_11695	COG0628	permease
D1814_11700	COG0673	inositol 2-dehydrogenase activity
D1814_11800	COG0795	lipopolysaccharide-transporting ATPase activity
D1814_11805	COG0795	lipopolysaccharide-transporting ATPase activity
D1814_11810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1814_11815	COG2927	DNA polymerase III (CHI subunit)
D1814_11820	COG0525	valine-tRNA ligase activity
D1814_11840	COG3706	GGDEF domain
D1814_11855	COG0204	Acyl-transferase
D1814_11860	COG3437	response regulator, receiver
D1814_11865	COG2204	response regulator
D1814_11870	COG3852	Histidine kinase
D1814_11880	COG0174	glutamine synthetase
D1814_11895	COG0436	Aminotransferase
D1814_11900	COG1914	H( )-stimulated, divalent metal cation uptake system
D1814_11950	COG0850	regulation of cytokinetic process
D1814_11955	COG2894	cell division
D1814_11975	COG0840	transmembrane signaling receptor activity
D1814_11985	COG0625	glutathione transferase activity
D1814_11990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1814_12005	COG1902	pentaerythritol trinitrate reductase activity
D1814_12015	COG0738	Major facilitator superfamily
D1814_12020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1814_12025	COG4942	peptidase
D1814_12030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1814_12050	COG5507	3-demethylubiquinone-9 3-methyltransferase
D1814_12055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1814_12075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1814_12080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1814_12085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1814_12100	COG0493	'glutamate synthase
D1814_12105	COG0069	glutamate synthase activity
D1814_12105	COG0067	glutamate synthase
D1814_12105	COG0070	glutamate synthase
D1814_12110	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1814_12115	COG2198	Histidine kinase
D1814_12115	COG5002	protein histidine kinase activity
D1814_12115	COG0784	Response regulator, receiver
D1814_12135	COG2203	Gaf domain
D1814_12135	COG2199	diguanylate cyclase activity
D1814_12145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1814_12150	COG0372	Belongs to the citrate synthase family
D1814_12155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1814_12180	COG2197	response regulator
D1814_12185	COG4585	Histidine kinase
D1814_12205	COG2823	Periplasmic or secreted lipoprotein
D1814_12225	COG3107	peptidoglycan biosynthetic process
D1814_12230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1814_12250	COG1748	Saccharopine dehydrogenase
D1814_12260	COG2207	Transcriptional regulator
D1814_12295	COG5002	protein histidine kinase activity
D1814_12295	COG3850	Histidine kinase
D1814_12305	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D1814_12315	COG0798	PFAM Bile acid sodium symporter
D1814_12320	COG0431	NADPH-dependent FMN reductase
D1814_12330	COG0640	Transcriptional regulator
D1814_12345	COG4585	Histidine kinase
D1814_12350	COG2197	response regulator
D1814_12360	COG0583	DNA-binding transcription factor activity
D1814_12375	COG0083	homoserine kinase activity
D1814_12380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1814_12385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1814_12420	COG0724	RNA recognition motif
D1814_12425	COG2814	Major facilitator Superfamily
D1814_12430	COG1396	sequence-specific DNA binding
D1814_12435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D1814_12445	COG2323	membrane
D1814_12450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1814_12455	COG1764	response to oxidative stress
D1814_12465	COG0625	glutathione transferase activity
D1814_12480	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1814_12480	COG1902	pentaerythritol trinitrate reductase activity
D1814_12490	COG0762	integral membrane protein
D1814_12495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1814_12520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1814_12525	COG1678	Uncharacterized ACR, COG1678
D1814_12530	COG0189	ligase activity
D1814_12535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1814_12540	COG0668	transmembrane transport
D1814_12565	COG2271	Major facilitator Superfamily
D1814_12580	COG2205	protein histidine kinase activity
D1814_12580	COG0784	Response regulator, receiver
D1814_12585	COG2204	response regulator
D1814_12595	COG3706	GGDEF domain
D1814_12610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1814_12610	COG0678	peroxiredoxin activity
D1814_12630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_12635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_12655	COG2001	Belongs to the MraZ family
D1814_12665	COG3116	cell division
D1814_12670	COG0768	penicillin binding
D1814_12675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1814_12680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1814_12695	COG0772	Belongs to the SEDS family
D1814_12710	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1814_12715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1814_12720	COG0849	cell division
D1814_12725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1814_12730	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1814_12735	COG0739	heme binding
D1814_12745	COG0494	nUDIX hydrolase
D1814_12750	COG3608	succinylglutamate desuccinylase aspartoacylase
D1814_12760	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D1814_12765	COG0237	dephospho-CoA kinase activity
D1814_12770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D1814_12775	COG1459	type II secretion system
D1814_12785	COG0157	Belongs to the NadC ModD family
D1814_12790	COG3577	Aspartyl protease
D1814_12795	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1814_12805	COG2186	Transcriptional regulator
D1814_12810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1814_12815	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1814_12820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1814_12835	COG0583	DNA-binding transcription factor activity
D1814_12855	COG3313	Fe-S protein
D1814_12880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1814_12885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1814_12890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1814_12895	COG2205	protein histidine kinase activity
D1814_12905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1814_12920	COG0006	proline dipeptidase activity
D1814_12925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1814_12930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1814_12955	COG0583	DNA-binding transcription factor activity
D1814_12960	COG2971	BadF BadG BcrA BcrD
D1814_12965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1814_12990	COG4771	TonB-dependent receptor
D1814_12995	COG1472	Belongs to the glycosyl hydrolase 3 family
D1814_13005	COG3275	phosphorelay sensor kinase activity
D1814_13030	COG2133	pyrroloquinoline quinone binding
D1814_13035	COG4251	negative regulation of phosphorylation
D1814_13065	COG0514	ATP-dependent DNA helicase (RecQ)
D1814_13090	COG2814	Major facilitator Superfamily
D1814_13120	COG4681	YaeQ
D1814_13155	COG1295	ribonuclease BN
D1814_13160	COG0693	protein deglycase activity
D1814_13165	COG4221	oxidoreductase activity
D1814_13170	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_13175	COG3706	GGDEF domain
D1814_13250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1814_13255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1814_13260	COG2080	2 iron, 2 sulfur cluster binding
D1814_13300	COG2205	protein histidine kinase activity
D1814_13305	COG0745	RESPONSE REGULATOR receiver
D1814_13335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1814_13340	COG1960	acyl-CoA dehydrogenase activity
D1814_13370	COG0789	Transcriptional regulator
D1814_13375	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D1814_13395	COG1012	belongs to the aldehyde dehydrogenase family
D1814_13425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1814_13430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1814_13455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1814_13460	COG1609	Transcriptional regulator
D1814_13470	COG1435	thymidine kinase activity
D1814_13490	COG1960	acyl-CoA dehydrogenase activity
D1814_13520	COG1560	Kdo2-lipid A biosynthetic process
D1814_13540	COG2827	Endonuclease containing a URI domain
D1814_13545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1814_13545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1814_13550	COG3409	Peptidoglycan-binding domain 1 protein
D1814_13550	COG3267	Type II secretory pathway component ExeA
D1814_13560	COG0489	protein tyrosine kinase activity
D1814_13595	COG1216	Glycosyl transferase, family 2
D1814_13595	COG0463	Glycosyl transferase, family 2
D1814_13625	COG2244	polysaccharide biosynthetic process
D1814_13630	COG0438	transferase activity, transferring glycosyl groups
D1814_13630	COG0297	glycogen (starch) synthase activity
D1814_13650	COG1215	transferase activity, transferring glycosyl groups
D1814_13655	COG1045	serine acetyltransferase
D1814_13680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1814_13695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1814_13715	COG1785	Belongs to the alkaline phosphatase family
D1814_13720	COG2066	Belongs to the glutaminase family
D1814_13750	COG0754	glutathionylspermidine amidase activity
D1814_13770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1814_13775	COG1842	Phage shock protein A
D1814_13795	COG0343	queuine tRNA-ribosyltransferase activity
D1814_13800	COG1862	Preprotein translocase
D1814_13805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1814_13810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1814_13815	COG0483	inositol monophosphate 1-phosphatase activity
D1814_13820	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1814_13825	COG1045	serine acetyltransferase
D1814_13830	COG3279	Response regulator of the LytR AlgR family
D1814_13835	COG3275	phosphorelay sensor kinase activity
D1814_13840	COG1131	(ABC) transporter
D1814_13850	COG2072	flavoprotein involved in K transport
D1814_13855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1814_13865	COG1104	cysteine desulfurase activity
D1814_13870	COG0719	Fe-S assembly protein
D1814_13875	COG0396	ATPase activity
D1814_13880	COG0719	Fe-S assembly protein
D1814_13885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1814_13900	COG2166	iron-sulfur cluster assembly
D1814_13910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1814_13915	COG3063	Type IV pilus biogenesis stability protein PilW
D1814_13920	COG1426	Protein conserved in bacteria
D1814_13935	COG2976	Protein conserved in bacteria
D1814_13940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1814_13960	COG1570	exodeoxyribonuclease VII activity
D1814_13965	COG0517	IMP dehydrogenase activity
D1814_13965	COG0516	GMP reductase activity
D1814_13990	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1814_14010	COG1720	tRNA m6t6A37 methyltransferase activity
D1814_14065	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1814_14070	COG0740	serine-type endopeptidase activity
D1814_14075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1814_14080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1814_14085	COG0776	regulation of translation
D1814_14090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1814_14120	COG0385	Bile acid
D1814_14125	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_14140	COG0268	Binds directly to 16S ribosomal RNA
D1814_14145	COG0728	peptidoglycan biosynthetic process
D1814_14150	COG0196	riboflavin kinase activity
D1814_14155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1814_14165	COG1047	Peptidyl-prolyl cis-trans
D1814_14170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1814_14230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1814_14250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1814_14265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1814_14270	COG1595	DNA-templated transcription, initiation
D1814_14295	COG0681	Belongs to the peptidase S26 family
D1814_14300	COG0571	ribonuclease III activity
D1814_14305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1814_14315	COG0084	hydrolase, TatD family'
D1814_14325	COG0560	Phosphoserine phosphatase
D1814_14335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1814_14345	COG0488	(ABC) transporter
D1814_14365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1814_14365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1814_14380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1814_14390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1814_14395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1814_14405	COG0142	geranyltranstransferase activity
D1814_14415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1814_14425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1814_14440	COG4221	oxidoreductase activity
D1814_14455	COG1595	DNA-templated transcription, initiation
D1814_14470	COG0564	pseudouridine synthase activity
D1814_14480	COG0542	response to heat
D1814_14485	COG0277	FAD linked oxidase domain protein
D1814_14505	COG1183	phosphatidylcholine synthase activity
D1814_14545	COG3220	belongs to the UPF0276 family
D1814_14555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1814_14560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1814_14570	COG4251	negative regulation of phosphorylation
D1814_14575	COG5001	Diguanylate cyclase
D1814_14585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1814_14590	COG0326	Molecular chaperone. Has ATPase activity
D1814_14620	COG0681	Belongs to the peptidase S26 family
D1814_14625	COG2116	formate transmembrane transporter activity
D1814_14635	COG0583	DNA-binding transcription factor activity
D1814_14650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1814_14650	COG0140	phosphoribosyl-ATP diphosphatase activity
D1814_14665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1814_14670	COG0131	Imidazoleglycerol-phosphate dehydratase
D1814_14670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1814_14675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1814_14680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1814_14685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1814_14730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_14735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_14760	COG1230	cation diffusion facilitator family transporter
D1814_14770	COG1199	ATP-dependent helicase activity
D1814_14775	COG1214	PFAM Peptidase M22, glycoprotease
D1814_14790	COG2267	carboxylic ester hydrolase activity
D1814_14795	COG0318	PFAM AMP-dependent synthetase and ligase
D1814_14800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1814_14815	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1814_14820	COG2983	Belongs to the UPF0260 family
D1814_14830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1814_14835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1814_14845	COG2186	Transcriptional regulator
D1814_14890	COG4399	Belongs to the UPF0754 family
D1814_14900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1814_14925	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1814_14925	COG1902	pentaerythritol trinitrate reductase activity
D1814_14965	COG0612	Peptidase, M16
D1814_14980	COG2031	fatty acid transporter
D1814_14985	COG1119	ATPase activity
D1814_14990	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_15015	COG1063	alcohol dehydrogenase
D1814_15020	COG0789	Transcriptional regulator
D1814_15060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1814_15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1814_15070	COG0318	PFAM AMP-dependent synthetase and ligase
D1814_15075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1814_15080	COG2161	toxin-antitoxin pair type II binding
D1814_15085	COG4115	mRNA cleavage
D1814_15125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1814_15150	COG0285	dihydrofolate synthase activity
D1814_15155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D1814_15160	COG1286	toxin biosynthetic process
D1814_15165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1814_15200	COG0583	DNA-binding transcription factor activity
D1814_15210	COG0753	catalase activity
D1814_15215	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_15230	COG0604	alcohol dehydrogenase
D1814_15235	COG1733	regulation of RNA biosynthetic process
D1814_15250	COG2268	Band 7 protein
D1814_15260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1814_15265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1814_15275	COG4774	siderophore transport
D1814_15285	COG1388	LysM domain
D1814_15285	COG0741	lytic transglycosylase activity
D1814_15295	COG2226	methyltransferase
D1814_15300	COG0668	transmembrane transport
D1814_15305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1814_15305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1814_15310	COG0489	protein tyrosine kinase activity
D1814_15320	COG0471	metal ion transport
D1814_15360	COG0210	DNA helicase
D1814_15380	COG3081	Nucleoid-associated protein
D1814_15395	COG4191	Histidine kinase
D1814_15395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1814_15400	COG0784	Response regulator, receiver
D1814_15400	COG3437	response regulator, receiver
D1814_15415	COG1902	pentaerythritol trinitrate reductase activity
D1814_15420	COG1979	alcohol dehydrogenase
D1814_15430	COG0583	DNA-binding transcription factor activity
D1814_15445	COG2356	endonuclease I
D1814_15475	COG3665	Urea carboxylase-associated protein
D1814_15500	COG0745	RESPONSE REGULATOR receiver
D1814_15505	COG2205	protein histidine kinase activity
D1814_15525	COG2823	Periplasmic or secreted lipoprotein
D1814_15540	COG0469	pyruvate kinase activity
D1814_15545	COG1737	Transcriptional regulator
D1814_15550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1814_15560	COG0129	dihydroxy-acid dehydratase activity
D1814_15570	COG0800	Aldolase
D1814_15575	COG0676	glucose-6-phosphate 1-epimerase activity
D1814_15580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1814_15585	COG1640	4-alpha-glucanotransferase
D1814_15590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1814_15600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1814_15620	COG2866	Carboxypeptidase
D1814_15625	COG1115	amino acid carrier protein
D1814_15640	COG3139	Protein of unknown function (DUF1315)
D1814_15690	COG0784	Response regulator, receiver
D1814_15690	COG2198	Histidine kinase
D1814_15690	COG5002	protein histidine kinase activity
D1814_15695	COG0784	Response regulator, receiver
D1814_15700	COG4251	negative regulation of phosphorylation
D1814_15710	COG2204	response regulator
D1814_15730	COG0640	Transcriptional regulator
D1814_15745	COG0583	DNA-binding transcription factor activity
D1814_15765	COG3300	MHYT domain
D1814_15765	COG5001	Diguanylate cyclase
D1814_15770	COG1022	Amp-dependent synthetase and ligase
D1814_15780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1814_15785	COG1074	ATP-dependent DNA helicase activity
D1814_15790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1814_15800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1814_15825	COG2094	Belongs to the DNA glycosylase MPG family
D1814_15840	COG2146	nitrite reductase [NAD(P)H] activity
D1814_15840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1814_15845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1814_15885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1814_15905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D1814_15920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1814_15925	COG3268	Saccharopine dehydrogenase
D1814_16000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1814_16005	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1814_16010	COG0315	cyclic pyranopterin monophosphate synthase activity
D1814_16015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1814_16020	COG0314	molybdopterin synthase activity
D1814_16035	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D1814_16035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1814_16040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1814_16070	COG1960	acyl-CoA dehydrogenase activity
D1814_16080	COG0604	alcohol dehydrogenase
D1814_16090	COG0366	Alpha amylase catalytic
D1814_16095	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_16105	COG3012	SEC-C Motif Domain Protein
D1814_16135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1814_16140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1814_16145	COG0436	Aminotransferase
D1814_16160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1814_16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1814_16175	COG1765	OsmC-like protein
D1814_16180	COG2996	Protein conserved in bacteria
D1814_16190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1814_16195	COG1984	allophanate hydrolase subunit 2
D1814_16205	COG0735	belongs to the Fur family
D1814_16215	COG0716	FMN binding
D1814_16225	COG0596	Alpha beta hydrolase
D1814_16230	COG2916	Histone family protein nucleoid-structuring protein H-NS
D1814_16265	COG1505	serine-type exopeptidase activity
D1814_16280	COG2207	Transcriptional regulator
D1814_16280	COG0662	Cupin 2, conserved barrel domain protein
D1814_16285	COG1960	acyl-CoA dehydrogenase activity
D1814_16290	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_16295	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_16300	COG1671	Belongs to the UPF0178 family
D1814_16310	COG1448	Aminotransferase
D1814_16360	COG0405	Gamma-glutamyltransferase
D1814_16470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1814_16475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1814_16490	COG0534	Mate efflux family protein
D1814_16495	COG0303	'Molybdopterin
D1814_16515	COG1215	transferase activity, transferring glycosyl groups
D1814_16520	COG3769	mannosylglycerate metabolic process
D1814_16525	COG0572	uridine kinase
D1814_16550	COG1960	acyl-CoA dehydrogenase activity
D1814_16560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1814_16590	COG1393	Belongs to the ArsC family
D1814_16600	COG4783	chaperone-mediated protein folding
D1814_16610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1814_16620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1814_16625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D1814_16655	COG0633	Ferredoxin
D1814_16660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1814_16665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1814_16670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1814_16680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1814_16685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1814_16690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1814_16695	COG0539	negative regulation of cytoplasmic translation
D1814_16700	COG0776	regulation of translation
D1814_16715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D1814_16720	COG0284	orotidine-5'-phosphate decarboxylase activity
D1814_16725	COG0686	Belongs to the AlaDH PNT family
D1814_16735	COG0531	amino acid
D1814_16735	COG1674	ftsk spoiiie
D1814_16745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1814_16775	COG2920	part of a sulfur-relay system
D1814_16790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1814_16795	COG0670	Belongs to the BI1 family
D1814_16830	COG1741	Belongs to the pirin family
D1814_16835	COG2197	response regulator
D1814_16840	COG0322	excinuclease ABC activity
D1814_16920	COG5532	Uncharacterized conserved protein (DUF2303)
D1814_16935	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1814_17110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1814_17115	COG2897	thiosulfate sulfurtransferase activity
D1814_17120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1814_17125	COG1280	lysine exporter protein (LysE YggA)
D1814_17145	COG1752	Esterase of the alpha-beta hydrolase superfamily
D1814_17155	COG0589	response to stress
D1814_17160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1814_17185	COG2010	Cytochrome c
D1814_17200	COG3278	Belongs to the heme-copper respiratory oxidase family
D1814_17210	COG2193	ferroxidase activity
D1814_17225	COG0069	glutamate synthase activity
D1814_17235	COG0589	response to stress
D1814_17245	COG4974	Belongs to the 'phage' integrase family
D1814_17275	COG1082	Xylose isomerase domain protein TIM barrel
D1814_17280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1814_17285	COG0318	PFAM AMP-dependent synthetase and ligase
D1814_17290	COG4264	IucA IucC family
D1814_17310	COG3046	protein related to deoxyribodipyrimidine photolyase
D1814_17315	COG0415	Belongs to the DNA photolyase family
D1814_17320	COG0415	Belongs to the DNA photolyase family
D1814_17325	COG0415	Belongs to the DNA photolyase family
D1814_17335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1814_17340	COG3130	regulation of translation
D1814_17365	COG0167	dihydroorotate dehydrogenase activity
D1814_17370	COG2902	Dehydrogenase
D1814_17400	COG0308	aminopeptidase N
D1814_17410	COG0733	neurotransmitter:sodium symporter activity
D1814_17415	COG0793	Belongs to the peptidase S41A family
D1814_17430	COG1956	GAF domain-containing protein
D1814_17440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1814_17450	COG1946	Acyl-CoA thioesterase
D1814_17455	COG0515	serine threonine protein kinase
D1814_17460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1814_17465	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1814_17470	COG0022	dehydrogenase e1 component
D1814_17475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1814_17480	COG1404	Belongs to the peptidase S8 family
D1814_17485	COG1322	Protein conserved in bacteria
D1814_17505	COG1760	l-serine dehydratase
D1814_17525	COG0583	DNA-binding transcription factor activity
D1814_17530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1814_17540	COG0513	Belongs to the DEAD box helicase family
D1814_17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1814_17590	COG2205	protein histidine kinase activity
D1814_17610	COG0205	6-phosphofructokinase activity
D1814_17615	COG3279	Response regulator of the LytR AlgR family
D1814_17620	COG3275	phosphorelay sensor kinase activity
D1814_17640	COG0739	heme binding
D1814_17640	COG0741	lytic transglycosylase activity
D1814_17640	COG1196	nuclear chromosome segregation
D1814_17650	COG3081	Nucleoid-associated protein
D1814_17655	COG3082	Protein of unknown function (DUF1414)
D1814_17660	COG3083	sulfuric ester hydrolase activity
D1814_17665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1814_17670	COG2226	methyltransferase
D1814_17675	COG1024	Enoyl-CoA hydratase
D1814_17680	COG1960	acyl-CoA dehydrogenase activity
D1814_17690	COG2084	Dehydrogenase
D1814_17695	COG0386	Belongs to the glutathione peroxidase family
D1814_17700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1814_17705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1814_17710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1814_17725	COG0616	signal peptide processing
D1814_17735	COG2267	carboxylic ester hydrolase activity
D1814_17740	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_17765	COG0366	Alpha amylase catalytic
D1814_17785	COG4667	esterase of the alpha-beta hydrolase superfamily
D1814_17825	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1814_17830	COG0567	Dehydrogenase, E1 component
D1814_17835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1814_17840	COG1053	succinate dehydrogenase
D1814_17845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D1814_17850	COG2009	succinate dehydrogenase
D1814_17855	COG0372	Belongs to the citrate synthase family
D1814_17870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1814_17880	COG0435	Glutathione S-transferase
D1814_17885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1814_17920	COG1663	tetraacyldisaccharide 4'-kinase activity
D1814_17925	COG1132	(ABC) transporter
D1814_17940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1814_17950	COG1196	nuclear chromosome segregation
D1814_17955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1814_18070	COG3011	Protein conserved in bacteria
D1814_18185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1814_18200	COG0561	phosphatase activity
D1814_18215	COG1803	Methylglyoxal synthase
D1814_18215	COG1597	lipid kinase activity
D1814_18245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1814_18250	COG0149	triose-phosphate isomerase activity
D1814_18255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1814_18260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1814_18265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1814_18270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1814_18275	COG1534	Rna-binding protein
D1814_18285	COG1067	ATP-dependent peptidase activity
D1814_18295	COG0495	leucyl-tRNA aminoacylation
D1814_18300	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1814_18305	COG1466	dna polymerase III delta subunit
D1814_18310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1814_18315	COG0799	negative regulation of ribosome biogenesis
D1814_18320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1814_18325	COG0768	penicillin binding
D1814_18330	COG0772	Belongs to the SEDS family
D1814_18335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1814_18340	COG1686	Belongs to the peptidase S11 family
D1814_18345	COG2921	Belongs to the UPF0250 family
D1814_18350	COG0321	lipoyl(octanoyl) transferase activity
D1814_18355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1814_18360	COG0252	asparaginase activity
D1814_18370	COG0778	Nitroreductase
D1814_18385	COG0616	signal peptide processing
D1814_18390	COG3091	SprT-like family
D1814_18395	COG3092	negative regulation of chromosome organization
D1814_18400	COG0492	ferredoxin-NADP+ reductase activity
D1814_18405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1814_18410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D1814_18415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1814_18420	COG0542	response to heat
D1814_18425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1814_18430	COG1278	Cold shock
D1814_18440	COG1187	pseudouridine synthase activity
D1814_18445	COG0482	sulfurtransferase activity
D1814_18450	COG2915	High frequency lysogenization protein hflD homolog
D1814_18455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1814_18465	COG2850	peptidyl-arginine hydroxylation
D1814_18495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1814_18495	COG0574	Belongs to the PEP-utilizing enzyme family
D1814_18515	COG0457	Tetratricopeptide repeat
D1814_18520	COG4771	TonB-dependent receptor
D1814_18525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1814_18535	COG2914	Belongs to the UPF0125 (RnfH) family
D1814_18540	COG2867	negative regulation of translational initiation
D1814_18550	COG1902	pentaerythritol trinitrate reductase activity
D1814_18565	COG1131	(ABC) transporter
D1814_18600	COG0583	DNA-binding transcription factor activity
D1814_18640	COG5001	Diguanylate cyclase
D1814_18640	COG4251	negative regulation of phosphorylation
D1814_18640	COG3706	GGDEF domain
D1814_18640	COG2203	Gaf domain
D1814_18660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1814_18665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1814_18675	COG4134	Bacterial extracellular solute-binding protein
D1814_18685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1814_18690	COG4771	TonB-dependent receptor
D1814_18705	COG1032	radical SAM domain protein
D1814_18750	COG0450	alkyl hydroperoxide reductase
D1814_18775	COG3153	acetyltransferase
D1814_18775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1814_18785	COG1187	pseudouridine synthase activity
D1814_18800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1814_18815	COG0195	Participates in both transcription termination and antitermination
D1814_18825	COG3437	response regulator, receiver
D1814_18830	COG2198	Histidine kinase
D1814_18830	COG0784	Response regulator, receiver
D1814_18830	COG5002	protein histidine kinase activity
D1814_18855	COG4771	TonB-dependent receptor
D1814_18860	COG0668	transmembrane transport
D1814_18880	COG0277	FAD linked oxidase domain protein
D1814_18880	COG0247	lactate metabolic process
D1814_18885	COG0523	cobalamin synthesis protein
D1814_18895	COG0735	belongs to the Fur family
D1814_18905	COG0246	Mannitol dehydrogenase
D1814_18915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1814_18940	COG1960	acyl-CoA dehydrogenase activity
D1814_18945	COG0183	Belongs to the thiolase family
D1814_18955	COG0596	Alpha beta hydrolase
D1814_18960	COG1028	Short-chain dehydrogenase reductase Sdr
D1814_18985	COG3706	GGDEF domain
D1814_18990	COG0702	epimerase
D1814_19000	COG0084	hydrolase, TatD family'
D1814_19015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1814_19020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1814_19025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1814_19030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1814_19040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1814_19045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1814_19050	COG0416	fatty acid biosynthetic process
D1814_19060	COG1399	metal-binding, possibly nucleic acid-binding protein
D1814_19065	COG0424	maF-like protein
D1814_19070	COG0546	phosphoglycolate phosphatase activity
D1814_19080	COG1530	ribonuclease E activity
D1814_19095	COG2153	protein acetylation
D1814_19110	COG0625	glutathione transferase activity
D1814_19120	COG0243	molybdopterin cofactor binding
D1814_19125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1814_19130	COG0746	molybdenum cofactor guanylyltransferase activity
D1814_19140	COG3122	Protein conserved in bacteria
D1814_19145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1814_19150	COG3724	N-succinylarginine dihydrolase activity
D1814_19160	COG1301	dicarboxylic acid transport
D1814_19165	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1814_19170	COG1136	(ABC) transporter
D1814_19175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D1814_19205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1814_19210	COG0328	RNA-DNA hybrid ribonuclease activity
D1814_19215	COG0604	alcohol dehydrogenase
D1814_19215	COG3321	synthase
D1814_19235	COG1643	Atp-dependent helicase
D1814_19280	COG2925	Exonuclease
D1814_19290	COG5001	Diguanylate cyclase
D1814_19290	COG3447	MASE1 domain protein
D1814_19290	COG5002	protein histidine kinase activity
D1814_19305	COG0183	Belongs to the thiolase family
D1814_19310	COG0789	Transcriptional regulator
D1814_19315	COG1960	acyl-CoA dehydrogenase activity
D1814_19320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1814_19325	COG1024	Enoyl-CoA hydratase